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Mariana Baz Etchebarne

Professeure adjointe

mariana.baz-etchebarne.1@ulaval.ca
Centre de recherche du CHU de Québec - Université Laval
Centre de recherche en infectiologie
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Contribution à la recherche

Projets de recherche

  • Canada Research Chair in Pre-pandemic and Pandemic viruses and therapeutic strategies - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2023-05-01 au 2028-04-29
  • Développement de tests sérologiques pour les virus respiratoires et les virus de la variole du singe. - CHU de Québec – Université Laval – CHUL - Développement de la recherche (FC), chercheur principal - 2023-04-01 au 2026-03-31
  • Aerosol Infection Research: Better mOdels to Reduce iNdoor Exposure (AIRBORNE) - Medical Research Future Fund - 2021 Coronavirus Research Response – Covid-19 Treatment Access and Public Health Activities, The University of Melbourne, co-chercheur - 2022-06-01 au 2025-05-30
  • Chaire de recherche Sentinelle Nord sur les virus pandémique et thérapies antivirales - Secrétariat des programmes interorganismes à l’intention des établissements - Fonds d'excellence en recherche Apogée Canada, chercheur principal - 2022-04-01 au 2025-03-31
  • Plateforme de laboratoire de niveau de confinement 3 pour la recherche sur les virus émergents - CHU de Québec – Université Laval – CHUL, Ministère de l'Économie et de l'Innovation - Appel de projets en appui aux plateformes technologiques stratégiques, co-chercheur - 2023-01-31 au 2025-03-31
  • Virus pré-pandémiques et pandémiques et stratégies thérapeutiques - Ministère de la Santé et des Services sociaux, Fondation Canadienne pour l'innovation (La) - Fonds des leaders John-R.-Evans (FLJR), chercheur principal - 2023-04-01 au 2024-12-31
  • Optimization of a live microneutralization assay to evaluate antibody levels against mpox in vaccinated or infected individuals in Quebec - Université Laval - Fonds internes - BDR - Contributions, chercheur principal - 2023-04-24 au 2024-04-23
  • Immunocompromised ferret model of influenza virus infection: a relevant model for the evaluation of combination therapeutic options - CHU de Québec – Université Laval – CHUL - Aide à la recherche, chercheur principal - 2023-11-08 au 2024-03-31
  • Preclinical proof of concept studies of a new generation of TLR7/8 agonist used in prevention against respiratory viruses and in immunotherapy against lung cancer - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2023-03-01 au 2024-02-29
  • Fonds de démarrage, Mariana Baz. La grippe à l'interface entre l'homme et l'animal: émergence et contrôle - CHU de Québec – Université Laval – CHUL, Fondation du CHU de Québec - Fonds de démarrage, chercheur principal - 2020-04-13 au 2023-04-12
  • Prevention of the immunopathology induced by SARS-CoV-2 - Instituts de recherche en santé du Canada - Subvention de fonctionnement : Possibilité de financement sur les nouveaux besoins prioritaires en recherche sur la COVID-19, co-chercheur - 2021-06-01 au 2022-05-31
  • Immunité cellulaire et séroprévalence des anticorps contre SARS-COV-2: Caratérisation de trois populations de travailleurs de l'alimentation - Agence de la santé publique du Canada, co-chercheur - 2020-11-01 au 2022-03-31
  • Innovative therapeutic approaches for the 2019-novel coronavirus - Instituts de recherche en santé du Canada, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Subvention de fonctionnement : Possibilité de financement canadienne pour une intervention de recherche rapide contre la maladie à coronavirus 2019 (COVID-19), co-chercheur - 2021-03-01 au 2022-02-28
  • Understanding the pathogenesis of COVID-19 - Instituts de recherche en santé du Canada, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Subvention de fonctionnement : Possibilité de financement canadienne pour une intervention de recherche rapide contre la maladie à coronavirus 2019 (COVID-19), co-chercheur - 2020-03-01 au 2021-02-28

Publications

  • Structural Insight into NS5 of Zika Virus Leading to the Discovery of MTase Inhibitors, , Journal of the American Chemical Society, 2016, 10.1021/jacs.6b10399
  • Household Transmission of the 2009 Pandemic A/H1N1 Influenza Virus: Elevated Laboratory‐Confirmed Secondary Attack Rates and Evidence of Asymptomatic Infections, , Clinical Infectious Diseases, 2010, 10.1086/656582
  • Effect of the Neuraminidase Mutation H274Y Conferring Resistance to Oseltamivir on the Replicative Capacity and Virulence of Old and Recent Human Influenza A(H1N1) Viruses, , The Journal of Infectious Diseases, 2010, 10.1086/650464
  • Evolution of Oseltamivir Resistance Mutations in Influenza A(H1N1) and A(H3N2) Viruses during Selection in Experimentally Infected Mice, , Antimicrobial Agents and Chemotherapy, 2014, 10.1128/aac.02956-14
  • Replication and Immunogenicity of Swine, Equine, and Avian H3 Subtype Influenza Viruses in Mice and Ferrets, , Journal of Virology, 2013, 10.1128/jvi.03520-12
  • Oseltamivir-Resistant Pandemic A/H1N1 Virus Is as Virulent as Its Wild-Type Counterpart in Mice and Ferrets, , PLoS Pathogens, 2010, 10.1371/journal.ppat.1001015
  • Impact of R152K and R368K neuraminidase catalytic substitutions on in vitro properties and virulence of recombinant A(H1N1)pdm09 viruses, , Antiviral Research, 2018, 10.1016/j.antiviral.2018.04.009
  • Impact of the Baloxavir-Resistant Polymerase Acid I38T Substitution on the Fitness of Contemporary Influenza A(H1N1)pdm09 and A(H3N2) Strains, , The Journal of Infectious Diseases, 2020, 10.1093/infdis/jiz418
  • Seroconversion to Seasonal Influenza Viruses after A(H1N1)pdm09 Virus Infection, Quebec, Canada, , Emerging Infectious Diseases, 2012, 10.3201/eid1807.111680
  • Activity of the neuraminidase inhibitor A-315675 against oseltamivir-resistant influenza neuraminidases of N1 and N2 subtypes, , Antiviral Research, 2008, 10.1016/j.antiviral.2007.08.008
  • Nonreplicating Influenza A Virus Vaccines Confer Broad Protection against Lethal Challenge, , mBio, 2015, 10.1128/mbio.01487-15
  • Preclinical and clinical developments for combination treatment of influenza, Mariana Baz, Kanta Subbarao, Paulina Koszalka, PLOS Pathogens, 2022, 10.1371/journal.ppat.1010481
  • The quest for a nanoparticle-based vaccine inducing broad protection to influenza viruses, , Nanomedicine: Nanotechnology, Biology and Medicine, 2018, 10.1016/j.nano.2018.08.010
  • Influenza B viruses isolated in Uruguay during the 2002–2005 seasons: Genetic relations and vaccine strain match, , Virus Research, 2007, 10.1016/j.virusres.2006.08.002
  • Effects of Different Drug Combinations in Immunodeficient Mice Infected with an Influenza A/H3N2 Virus, , Microorganisms, 2020, 10.3390/microorganisms8121968
  • A Single Dose of an Avian H3N8 Influenza Virus Vaccine Is Highly Immunogenic and Efficacious against a Recently Emerged Seal Influenza Virus in Mice and Ferrets, , Journal of Virology, 2015, 10.1128/jvi.00280-15
  • Characterization of Multidrug-Resistant Influenza A/H3N2 Viruses Shed during 1 Year by an Immunocompromised Child, , Clinical Infectious Diseases, 2006, 10.1086/508777
  • Pre-Clinical Evaluation of the Antiviral Activity of Epigalocatechin-3-Gallate, a Component of Green Tea, against Influenza A(H1N1)pdm Viruses, Mariana Baz, Yves Desjardins, Nikita Deshpande, Paulina Koszalka, Harry Stannard, Viruses, 2023, 10.3390/v15122447
  • Development of Clade-Specific and Broadly Reactive Live Attenuated Influenza Virus Vaccines against Rapidly Evolving H5 Subtype Viruses, , Journal of Virology, 2017, 10.1128/jvi.00547-17
  • Predominant role of IPS-1 over TRIF adaptor proteins in early innate immune response against Zika virus in mice, , Journal of General Virology, 2018, 10.1099/jgv.0.000992
  • An addition to treatment options for avian influenza A H5N1?, , The Lancet Infectious Diseases, 2015, 10.1016/s1473-3099(15)70019-8
  • In Vitro Combinations of Baloxavir Acid and Other Inhibitors against Seasonal Influenza A Viruses, , Viruses, 2020, 10.3390/v12101139
  • A Novel Neuraminidase Deletion Mutation Conferring Resistance to Oseltamivir in Clinical Influenza A/H3N2 Virus, , The Journal of Infectious Diseases, 2009, 10.1086/595736
  • Zika Virus Isolation, Purification, and Titration, , Methods in Molecular Biology, 2020, 10.1007/978-1-0716-0581-3_2
  • Effects of Different Adjuvants in the Context of Intramuscular and Intranasal Routes on Humoral and Cellular Immune Responses Induced by Detergent-Split A/H3N2 Influenza Vaccines in Mice, , Clinical and Vaccine Immunology, 2012, 10.1128/cvi.05441-11
  • Longitudinal Study on Seroprevalence and Immune Response to SARS-CoV-2 in a Population of Food and Retail Workers Through Transformation of ELISA Datasets, Joelle N. Pelletier, Daniela Quaglia, Sylvie Trottier, Marc-André Langlois, Jean-Francois Masson, Mariana Baz, Denis Boudreau, Caroline Gilbert, Kim Santerre, Mathieu Thériault, Yves Durocher, Matthew Stuible, Étienne Lavallée, Megan-Faye Parker, Abdelhadi Djaïleb, 2024, 10.1101/2024.01.27.24301877
  • Synergistic PA and HA mutations confer mouse adaptation of a contemporary A/H3N2 influenza virus, , Scientific Reports, 2019, 10.1038/s41598-019-51877-4
  • ISCOM-like Nanoparticles Formulated with Quillaja brasiliensis Saponins Are Promising Adjuvants for Seasonal Influenza Vaccines, Fernando Silveira, Cibulski, S., Paulo Roehe;. Roehe, P.M.; Roehe, Paulo; Paulo Michel Roehe; , Mariana Baz, María Moreno, Mariana Rivera-Patron, Vaccines, 2021, 10.3390/vaccines9111350
  • In vitro and in vivo evidence of a potential A(H1N1)pdm09 antigenic drift mediated by escape mutations in the haemagglutinin Sa antigenic site, , Journal of General Virology, 2017, 10.1099/jgv.0.000800
  • H5N1 vaccines in humans, , Virus Research, 2013, 10.1016/j.virusres.2013.05.006
  • Characterization of drug-resistant recombinant influenza A/H1N1 viruses selected in vitro with peramivir and zanamivir, , Antiviral Research, 2007, 10.1016/j.antiviral.2006.10.012
  • Infections by Human Coronavirus-NL in Hospitalized Children, , The Pediatric Infectious Disease Journal, 2005, 10.1097/01.inf.0000183743.68569.c7
  • Development of a universal influenza A vaccine based on the M2e peptide fused to the papaya mosaic virus (PapMV) vaccine platform, , Vaccine, 2008, 10.1016/j.vaccine.2008.04.052
  • Cohort Profile: Prospective Cohort to Study the COVID-19 Immune Response in Retail Workers in Québec, Canada (CISACOV), Sylvie Trottier, Denis Boudreau, Mariana Baz, Jean-François Masson, Caroline Gilbert, Joelle N. Pelletier, Samuel Rochette, Nicholas Brousseau, Mathieu Thériault, Kim Santerre, 2023, 10.1101/2023.08.18.23294172
  • Emergence of Oseltamivir-Resistant Pandemic H1N1 Virus during Prophylaxis, , New England Journal of Medicine, 2009, 10.1056/nejmc0910060
  • Evaluation of Serological Diagnostic Methods for the 2009 Pandemic Influenza A (H1N1) Virus, , Clinical and Vaccine Immunology, 2011, 10.1128/cvi.00449-10
  • Immunogenicity and tolerability of an inactivated and adjuvanted pandemic H1N1 influenza vaccine, in HIV-1-infected patients, , Vaccine, 2011, 10.1016/j.vaccine.2010.12.023
  • Activity of the Oral Neuraminidase Inhibitor A-322278 against the Oseltamivir-Resistant H274Y (A/H1N1) Influenza Virus Mutant in Mice, , Antimicrobial Agents and Chemotherapy, 2009, 10.1128/aac.01276-08
  • Antiviral Agents in Development for Zika Virus Infections, , Pharmaceuticals, 2019, 10.3390/ph12030101
  • A Live Attenuated Equine H3N8 Influenza Vaccine Is Highly Immunogenic and Efficacious in Mice and Ferrets, , Journal of Virology, 2015, 10.1128/jvi.02449-14
  • In vitro susceptibility of geographically and temporally distinct zika viruses to favipiravir and ribavirin, , Antiviral Therapy, 2017, 10.3851/imp3180
  • Combination Therapy with Oseltamivir and Favipiravir Delays Mortality but Does Not Prevent Oseltamivir Resistance in Immunodeficient Mice Infected with Pandemic A(H1N1) Influenza Virus, , Viruses, 2018, 10.3390/v10110610
  • Reduced airborne transmission of oseltamivir-resistant pandemic A/H1N1 virus in ferrets, , Antiviral Therapy, 2011, 10.3851/imp1794
  • Development of a High-Yield Live Attenuated H7N9 Influenza Virus Vaccine That Provides Protection against Homologous and Heterologous H7 Wild-Type Viruses in Ferrets, , Journal of Virology, 2014, 10.1128/jvi.00100-14

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Andrea Carolina Arroyave Saldarriaga - Maîtrise avec mémoire - En cours
  • V. Nougnanké Croix Aude Wantchecon - Maîtrise avec mémoire - En cours
  • Ahmed Sahli - Doctorat - En cours
  • Zeineb M'hamdi - Doctorat - 2021/09
*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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