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Lucie Jeannotte

Professeure titulaire

Lucie Jeannotte
lucie.jeannotte@fmed.ulaval.ca
Centre de recherche sur le cancer
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Oncologie
Reproduction, génétique, périnatalité et développement
Santé cardiovasculaire, respiratoire et métabolisme

Domaines et intérêts de recherche du (de la) professeur(e) :

Cancer
  • Génétique du cancer
  • Cancer du poumon
  • Signalisation cellulaire et cancer
  • Facteurs de croissance
  • Cancer héréditaire
Santé circulatoire et respiratoire
  • Cellules souches et organogénèse
Santé de la mère, des enfants et des adolescents
  • Développement embryonnaire
  • Pathologies respiratoires du nouveau-né
  • Anomalies congénitales

Projets de recherche

  • Understanding how the master transcriptional regulator HOXA5 defines cell fate in the developing embryo - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC), Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2020-04-01 au 2025-03-31
  • Deciphering the role of the Yin Yang1 (YY1) transcription factor to understand pleuropulmonary blastoma - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2020-04-01 au 2025-03-31
  • Understanding the context-dependent roles of HOXA5 in cell fate and patterning - National Science Foundation (USA) - NSF 14-579 Facilitating Research at Primarily Undergraduate Institutions: Research in Undergraduate Institutions (RUI) and Research Opportunity Awards (ROA), Barnard College, co-chercheur - 2020-08-01 au 2023-07-31

Publications

  • Le rôle essentiel de MEK1 lors de l'angiogenèse placentaire, Jean Charron, Lucie Jeannotte, Médecine sciences : M/S, 1999
  • Low level of Hox1.3 gene expression does not preclude the use of promoterless vectors to generate a targeted gene disruption. off., Robertson EJ, Ruiz JC, Jeannotte L, Lucie Jeannotte, Molecular and cellular biology, 1991, 10.1128/mcb.11.11.5578-5585.1991
  • Analysis of beta 2-microglobulin gene expression in the developing mouse embryo and placenta., Robertson EJ, Bikoff EK, Jeannotte L, Jaffe L, Lucie Jeannotte, Journal of immunology (Baltimore, Md. : 1950), 1990
  • Molecular cloning and transcriptional mapping of the mouse cellular retinoic acid-binding protein gene., Nguyen-Huu MC, Jeannotte L, Chu YS, Tsao JL, Wei LN, Lucie Jeannotte, DNA and cell biology, 1990, 10.1089/dna.1990.9.471
  • Tissue-specific activity of the pro-opiomelanocortin (POMC) gene and repression by glucocorticoids., Tremblay Y, Jeannotte L, Sun YL, Therrien M, Gagner JP, Nemer M, Jean Charron, Jacques Drouin, Lucie Jeannotte, Genome, 1989, 10.1139/g89-099
  • Pro-opiomelanocortin gene: a model for negative regulation of transcription by glucocorticoids., Wrange O, Plante RK, Nemer M, Jeannotte L, Gagner JP, Jean Charron, Jean-Philippe Charron, Jacques Drouin, Lucie Jeannotte, Journal of cellular biochemistry, 1987, 10.1002/jcb.240350404
  • Reduced fertility in male mice deficient in the zinc metallopeptidase NL1., Jean Charron, DesGroseillers L, Jeannotte L, Boileau G, Janice Bailey, Guillemette C, Carpentier M, Lucie Jeannotte, Molecular and cellular biology, 2004, 10.1128/mcb.24.10.4428-4437.2004
  • [The PATCHED/Sonic Hedgehog signalling pathway in superficial bladder cancer]., Yves Fradet, Jeannotte L, Girard J, Sahar hamed, Hovington H, Lemieux P, Aboulkassim TO, Simoneau M, LaRue H, Lucie Jeannotte, Medecine sciences : M/S, 2003, 10.1051/medsci/20031910920
  • Perturbed thyroid morphology and transient hypothyroidism symptoms in Hoxa5 mutant mice., Jeannotte L, Meunier D, Aubin J, Lucie Jeannotte, Developmental dynamics : an official publication of the American Association of Anatomists, 2003, 10.1002/dvdy.10325
  • Sequence analysis of a Hoxa4-Hoxa5 intergenic region including shared regulatory elements., Jeannotte L, Moreau J, Lucie Jeannotte, DNA sequence : the journal of DNA sequencing and mapping, 2002, 10.1080/10425170290034507
  • Complete structure of the porcine pro-opiomelanocortin mRNA derived from the nucleotide sequence of cloned cDNA., Jacques Drouin, Chrétien M, Jeannotte L, Barbeau C, Boileau G, Lucie Jeannotte, Nucleic acids research, 1983, 10.1093/nar/11.22.8063
  • Hox patterning of the vertebrate rib cage., Wellik DM, Capecchi MR, Jeannotte L, Luke C. Loken, Yallowitz AR, Rakshit S, McIntyre DC, Lucie Jeannotte, Development (Cambridge, England), 2007, 10.1242/dev.007567
  • Impact of the loss of Hoxa5 function on lung alveogenesis., Jeannotte L, Tremblay GM, Janelle MF, Lalancette-Hébert M, LeBlanc M, Aubin J, Mandeville I, Lucie Jeannotte, The American journal of pathology, 2006, 10.2353/ajpath.2006.051333
  • Leukaemic transformation by CALM-AF10 involves upregulation of Hoxa5 by hDOT1L., Yi Zhang, Su L, Jeannotte L, Lemieux M, Jiang Q, Okada Y, Lucie Jeannotte, Nature cell biology, 2006, 10.1038/ncb1464
  • Cdx protein interaction with Hoxa5 regulatory sequences contributes to Hoxa5 regional expression along the axial skeleton., Jeannotte L, Tuggle CK, Woollard J, Carter M, Besch T, Lapointe J, Tabariès S, Lucie Jeannotte, Molecular and cellular biology, 2005, 10.1128/mcb.25.4.1389-1401.2005
  • Respiratory adaptations to lung morphological defects in adult mice lacking Hoxa5 gene function., Jeannotte L, Mandeville I, Lemieux M, Lalancette-Hébert M, Gulemetova R, LeBlanc M, Richard Kinkead, Lucie Jeannotte, Pediatric research, 2004, 10.1203/01.pdr.0000139427.26083.3d
  • Two large glycoprotein fragments related to the NH2-terminal part of the adrenocorticotropin-beta-lipotropin precursor are the end products of the maturation process in the rat pars intermedia., Chrétien M, Jeannotte L, Seidah NG, Crine P, Lucie Jeannotte, Canadian journal of biochemistry, 1980, 10.1139/o80-179
  • HOXA5 Participates in Brown Adipose Tissue and Epaxial Skeletal Muscle Patterning and in Brown Adipocyte Differentiation., Mansfield JH, Jeannotte L, Landry-Truchon K, Kyra A Schindler, Bergmann JM, Finkelstein TM, Ryckman A, Holzman MA, Lucie Jeannotte, Frontiers in cell and developmental biology, 2021, 10.3389/fcell.2021.632303
  • Phrenic-specific transcriptional programs shape respiratory motor output. , Polyxeni Philippidou, Landmesser LT, Niccolò Zampieri, Jeannotte L, Jared Cregg, Moore MT, Dewitz C, Garg K, Alicia Vagnozzi, Lucie Jeannotte, eLife, 2020, 10.7554/elife.52859
  • Deletion of Yy1 in mouse lung epithelium unveils molecular mechanisms governing pleuropulmonary blastoma pathogenesis, Lucie Jeannotte, Louise Galmiche-Rolland, William D. Foulkes, Christophe Delacourt, Alice Hadchouel, Louis Charron, Mickaël Lhuillier, Nicolas Houde, Kim Landry-Truchon, Disease Models & Mechanisms, 2020, 10.1242/dmm.045989
  • Correction: HOXA5 plays tissue-specific roles in the developing respiratory system (doi: 10.1242/dev.152686). , Jeannotte L, Mansfield JH, Polyxeni Philippidou, Dasen JS, Joncas FH, Boucherat O, Houde N, Landry-Truchon K, Lucie Jeannotte, Development (Cambridge, England), 2019, 10.1242/dev.184697
  • Four decades of Hox gene investigation and many more to go., Rezsohazy R, Jeannotte L, Gofflot F, Lucie Jeannotte, The International journal of developmental biology, 2018, 10.1387/ijdb.180332fg
  • HOXA5 plays tissue-specific roles in the developing respiratory system, Lucie Jeannotte, Jennifer H. Mansfield, Polyxeni Philippidou, Jeremy S. Dasen, France-Hélène Joncas, Olivier Boucherat, Nicolas Houde, Kim Landry-Truchon, Development, 2017, 10.1242/dev.152686
  • Crucial requirement of ERK/MAPK signaling in respiratory tract development., Jeannotte L, Charron J, Bérubé-Simard FA, Nadeau V, Lucie Jeannotte, Boucherat O, Development (Cambridge, England), 2015, 10.1242/dev.131821
  • YY1 acts as a transcriptional activator of Hoxa5 gene expression in mouse organogenesis., Jeannotte L, Prudhomme C, Bérubé-Simard FA, Lucie Jeannotte, PloS one, 2014, 10.1371/journal.pone.0093989
  • Hoxa5/Cre transgenic mice: novel tools for regional deletion along the anterior-posterior axis., Jeannotte L, Bérubé-Simard FA, Lucie Jeannotte, Genesis (New York, N.Y. : 2000), 2013, 10.1002/dvg.22733
  • Hox5 interacts with Plzf to restrict Shh expression in the developing forelimb., Wellik DM, Bennett Novitch, Gaber ZB, Jeannotte L, Takeuchi JK, Baker NC, McIntyre DC, Hrycaj SM, Xu B, Lucie Jeannotte, Proceedings of the National Academy of Sciences of the United States of America, 2013, 10.1073/pnas.1315075110
  • The loss of Hoxa5 function causes estrous acyclicity and ovarian epithelial inclusion cysts., Jeannotte L, Lemieux M, Aubin J, Boucherat O, Gendronneau G, Lucie Jeannotte, Endocrinology, 2012, 10.1210/en.2011-1766
  • Functional resolution of duplicated hoxb5 genes in teleosts., Ekker M, Jeannotte L, Bérubé-Simard FA, Aubin J, Grzyb M, Prudhomme C, Poitras L, Jarinova O, Hatch G, Lucie Jeannotte, Development (Cambridge, England), 2008, 10.1242/dev.025817
  • Unusual proopiomelanocortin ribonucleic acids in extrapituitary tissues: intronless transcripts in testes and long poly(A) tails in hypothalamus., Jacques Drouin, Burbach JP, Jeannotte L, Lucie Jeannotte, Molecular endocrinology (Baltimore, Md.), 1987, 10.1210/mend-1-10-749
  • Early postnatal lethality in Hoxa-5 mutant mice is attributable to respiratory tract defects., Jeannotte L, Bérard J, Tremblay M, Lemieux M, Aubin J, Lucie Jeannotte, Developmental biology, 1997, 10.1006/dbio.1997.8746
  • Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene., Alt FW, Robertson EJ, Goff SP, Jeannotte L, Stewart V, Fisher P, Malynn BA, Jean Charron, Lucie Jeannotte, Genes & development, 1992, 10.1101/gad.6.12a.2248
  • Transcriptional interferences at the Hoxa4/Hoxa5 locus: importance of correct Hoxa5 expression for the proper specification of the axial skeleton., Jeannotte L, Behringer RR, Tremblay M, Lemieux M, Aubin J, Lucie Jeannotte, Developmental dynamics : an official publication of the American Association of Anatomists, 1998, 10.1002/(sici)1097-0177(199805)212:1<141::aid-aja13>3.0.co;2-a
  • Multiple cis-acting regulatory regions are required for restricted spatio-temporal Hoxa5 gene expression., Jeannotte L, Aubin J, Bernier D, Tremblay M, Larochelle C, Lucie Jeannotte, Developmental dynamics : an official publication of the American Association of Anatomists, 1999, 10.1002/(sici)1097-0177(199902)214:2<127::aid-aja3>3.0.co;2-f
  • Accelerated induction of bladder cancer in patched heterozygous mutant mice., Yves Fradet, Latulippe E, Jeannotte L, Girard J, Hovington H, LaRue H, Sahar hamed, Lucie Jeannotte, Cancer research, 2004, 10.1158/0008-5472.can-03-2031
  • Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta., Jean Charron, Jeannotte L, Landry J, Huot J, Simon Rousseau, Larouche L, Aubry S, Cardin-Girard JF, Bernard D, Tremblay M, Giroux S, Lucie Jeannotte, Current biology : CB, 1999, 10.1016/s0960-9822(99)80164-x
  • Dynamic expression of murine HOXA5 protein in the central nervous system., Tuggle CK, Jeannotte L, Joksimovic M, Lucie Jeannotte, Gene expression patterns : GEP, 2005, 10.1016/j.modgep.2005.03.008
  • Transgenic mice ectopically expressing HOXA5 in the dorsal spinal cord show structural defects of the cervical spinal cord along with sensory and motor defects of the forelimb., Tuggle CK, Jeannotte L, Sonea IM, Lueth PA, Joksimovic M, Abbott MA, Krieger KE, Lucie Jeannotte, Brain research. Developmental brain research, 2004, 10.1016/j.devbrainres.2004.03.005
  • Comparative analysis of Hoxa5 allelic series., Jeannotte L, Aubin J, Lemieux M, Tabariès S, Lucie Jeannotte, Genesis (New York, N.Y. : 2000), 2007, 10.1002/dvg.20292
  • Stromal Hoxa5 function controls the growth and differentiation of mammary alveolar epithelium., Jeannotte L, Robinson GW, Coulombe Y, Lemieux M, Garin E, Lucie Jeannotte, Developmental dynamics : an official publication of the American Association of Anatomists, 2006, 10.1002/dvdy.20822
  • Lung development requires an active ERK/MAPK pathway in the lung mesenchyme., Jeannotte L, Jean Charron, Nadeau V, Houde N, Rifdat Aoidi, Landry-Truchon K, Boucherat O, Lucie Jeannotte, Developmental dynamics : an official publication of the American Association of Anatomists, 2016, 10.1002/dvdy.24464
  • Hoxa5: A Key Player in Development and Disease. , Landry-Truchon K, Gotti F, Jeannotte L, Lucie Jeannotte, Journal of developmental biology, 2016, 10.3390/jdb4020013
  • Unsuspected effects of a lung-specific Cre deleter mouse line., Provencher St-Pierre A, Montaron S, Lemieux M, Bourque S, Aubin J, Jeannotte L, Lucie Jeannotte, Genesis (New York, N.Y. : 2000), 2011, 10.1002/dvg.20720
  • Elexacaftor/Tezacaftor/Ivacaftor Disrupts Respiratory Tract Development in a Murine Fetal Lung Explant Model., Hadchouel A, Sermet-Gaudelus I, Jeannotte L, Delacourt C, Edelman A, Hinzpeter A, Chhun S, Houde N, Landry-Truchon K, Franco-Montoya ML, Dreano E, Aoust L, Lhuillier M, Lucie Jeannotte, American journal of respiratory cell and molecular biology, 2022, 10.1165/rcmb.2022-0175le
  • Loss of the zona pellucida-binding protein 2 (Zpbp2) gene in mice impacts airway hypersensitivity and lung lipid metabolism in a sex-dependent fashion., Anna K. Naumova, Radzioch D, Juan De Sanctis, Bourque G, Jeannotte L, Venuto D, Youssef M, Moussette S, Ho B, Chiwara V, Kanagaratham C, Lucie Jeannotte, Mammalian genome : official journal of the International Mammalian Genome Society, 2018, 10.1007/s00335-018-9743-x
  • Influence of Hoxa5 on p53 tumorigenic outcome in mice., Jeannotte L, Aubin J, Frenette N, Têtu B, Paradis J, Morneau M, Lemieux M, Gendronneau G, Lucie Jeannotte, The American journal of pathology, 2009, 10.2353/ajpath.2010.090499
  • [Hoxa5: a master gene with multifaceted roles]., Jeannotte L, Aubin J, Guillou F, Boucherat O, Lucie Jeannotte, Medecine sciences : M/S, 2009, 10.1051/medsci/200925177
  • Identification of Notch target genes in uncommitted T-cell progenitors: No direct induction of a T-cell specific gene program., Staal FJ, J.J.M. van Dongen, Jeannotte L, Koster EE, Brigitta Naber, Luis TC, Weerkamp F, Lucie Jeannotte, Leukemia, 2006, 10.1038/sj.leu.2404396
  • Stomach regional specification requires Hoxa5-driven mesenchymal-epithelial signaling., Jeannotte L, Chailler P, Lemieux M, Déry U, Aubin J, Lucie Jeannotte, Development (Cambridge, England), 2002, 10.1242/dev.129.17.4075
  • Cooperation of Hoxa5 and Pax1 genes during formation of the pectoral girdle., Jeannotte L, Lapointe J, Moreau J, Lemieux M, Aubin J, Lucie Jeannotte, Developmental biology, 2002, 10.1006/dbio.2002.0596
  • Implication des gènes Hox dans les processus d'organogenèse chez les mammifères, Aubin J, Lucie Jeannotte, Medecine sciences : M/S, 2001
  • Loss of Hoxa5 gene function in mice perturbs intestinal maturation., Jeannotte L, Ménard D, Chailler P, Aubin J, Lucie Jeannotte, The American journal of physiology, 1999, 10.1152/ajpcell.1999.277.5.c965
  • Hoxa5 gene regulation: A gradient of binding activity to a brachial spinal cord element., Tuggle CK, Jeannotte L, Nguyen-Huu MC, Larochelle C, Krieger KE, Zhou W, Nowling T, Lucie Jeannotte, Developmental biology, 1999, 10.1006/dbio.1998.9189
  • Specification of axial identity in the mouse: role of the Hoxa-5 (Hox1.3) gene., Robertson EJ, Poirier F, Jean Charron, Lemieux M, Jeannotte L, Lucie Jeannotte, Genes & development, 1993, 10.1101/gad.7.11.2085
  • Tissue-specific activity of the pro-opiomelanocortin gene promoter., Jacques Drouin, Chamberland M, Plante RK, Trifiro MA, Jeannotte L, Lucie Jeannotte, Molecular and cellular biology, 1987, 10.1128/mcb.7.11.4058-4064.1987
  • Structure of the rat pro-opiomelanocortin (POMC) gene., Nemer M, Jeannotte L, Jean-Philippe Charron, Jean Charron, Chamberland M, Jacques Drouin, Lucie Jeannotte, FEBS letters, 1985, 10.1016/0014-5793(85)80078-8
  • Chick embryo cells rendered respiration-deficient by chloramphenicol and ethidium bromide are auxotrophic for pyrimidines., Gravel D, Jeannotte L, Gregoire M, Morais R, Lucie Jeannotte, Biochemical and biophysical research communications, 1980, 10.1016/s0006-291x(80)80189-6
  • The loss of Hoxa5 function promotes Notch-dependent goblet cell metaplasia in lung airways., Jeannotte L, Chakir J, Boucherat O, Lucie Jeannotte, Biology open, 2012, 10.1242/bio.20121701
  • Multiple promoters and alternative splicing: Hoxa5 transcriptional complexity in the mouse embryo., Jeannotte L, Tuggle CK, Larochelle C, Guillou F, Boucherat O, Tabariès S, Bérubé-Simard FA, Joksimovic M, Aubin J, Moreau J, Lemieux M, Coulombe Y, Lucie Jeannotte, PloS one, 2010, 10.1371/journal.pone.0010600
  • Sustained Hox5 gene activity is required for respiratory motor neuron development., Dasen JS, Jeannotte L, Aubin J, Walsh CM, Polyxeni Philippidou, Lucie Jeannotte, Nature neuroscience, 2012, 10.1038/nn.3242
  • Partial functional redundancy between Hoxa5 and Hoxb5 paralog genes during lung morphogenesis., Jeannotte L, Dasen JS, Wellik DM, Polyxeni Philippidou, Aubin J, Bérubé-Simard FA, Montaron S, Boucherat O, Lucie Jeannotte, American journal of physiology. Lung cellular and molecular physiology, 2013, 10.1152/ajplung.00006.2013
  • Cellular and molecular mechanisms of goblet cell metaplasia in the respiratory airways., Delacourt C, Jeannotte L, Jorge Boczkowski, Boucherat O, Lucie Jeannotte, Experimental lung research, 2013, 10.3109/01902148.2013.791733
  • Crucial requirement of ERK/MAPK signaling in respiratory tract development., Jeannotte L, Jean Charron, Bérubé-Simard FA, Nadeau V, Boucherat O, Lucie Jeannotte, Development (Cambridge, England), 2014, 10.1242/dev.110254
  • Epithelial inactivation of Yy1 abrogates lung branching morphogenesis., Jeannotte L, Jean Charron, Delacourt C, William Foulkes, guillaume lezmi, Beuret L, Houde N, Bérubé-Simard FA, Landry-Truchon K, Boucherat O, Lucie Jeannotte, Development (Cambridge, England), 2015, 10.1242/dev.120469
  • Respiratory consequences of targeted losses of Hoxa5 gene function in mice, Richard Kinkead, Lucie Jeannotte, Jean-Philippe Rousseau, Nicolas Houde, Stéphanie Fournier, Kim Landry-Truchon, Journal of Experimental Biology, 2017, 10.1242/jeb.165084
  • Conditional Loss of Hoxa5 Function Early after Birth Impacts on Expression of Genes with Synaptic Function., Gofflot F, Ahmad Salti, Jeannotte L, Ahn MT, Sacré T, Mouheiche J, Moens C, Lizen B, Lucie Jeannotte, Frontiers in molecular neuroscience, 2017, 10.3389/fnmol.2017.00369
  • Pathomechanisms of Congenital Cystic Lung Diseases: Focus on Congenital Cystic Adenomatoid Malformation and Pleuropulmonary Blastoma., Benachi A, Delacourt C, Hadchouel A, Jeannotte L, Boucherat O, Lucie Jeannotte, Paediatric respiratory reviews, 2016, 10.1016/j.prrv.2015.11.011
  • Perinatal induction of Cre recombination with tamoxifen., Gofflot F, Filippo M. RIJLI, Jeannotte L, Claus M, Lizen B, Lucie Jeannotte, Transgenic research, 2015, 10.1007/s11248-015-9905-5
  • Lung cancer susceptibility genetic variants modulate HOXB2 expression in the lung., Bossé Y, Jeannotte L, Wim Timens, Obeidat M, Morissette M, Laplante M, Secco B, Gobeil S, Philippe Joubert, Biardel S, Lamontagne M, Landry-Truchon K, Boucherat O, Clemenceau A, Lucie Jeannotte, The International journal of developmental biology, 2018, 10.1387/ijdb.180210yb
  • Hoxa5 Activity Across the Lateral Somitic Frontier Regulates Development of the Mouse Sternum., Mansfield JH, Jeannotte L, Holzman MA, Kyra A Schindler, Finkelstein TM, Brent AE, Bergmann JM, Mitchel K, Lucie Jeannotte, Frontiers in cell and developmental biology, 2022, 10.3389/fcell.2022.806545
  • A scientific journey in the garden of the Hox genes: an interview with Jacqueline Deschamps., Rezsohazy R, Jeannotte L, Gofflot F, Lucie Jeannotte, The International journal of developmental biology, 2018, 10.1387/ijdb.180305rr
  • HOXA5 protein expression and genetic fate mapping show lineage restriction in the developing musculoskeletal system., Mansfield JH, Jeannotte L, Landry-Truchon K, Feldman M, Jenna Bergmann, Holzman MA, Lucie Jeannotte, The International journal of developmental biology, 2018, 10.1387/ijdb.180214jm

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Mickael Lhuillier - Doctorat - En cours
  • Josselin Guéno - Post-doctorat - En cours
  • Beatrice Frenette - Maîtrise avec mémoire - En cours
  • Henriette Pascale Ontchangalt - Maîtrise avec mémoire - 2013/09
  • Kim Landry-Truchon - Maîtrise avec mémoire - 2015/09

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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