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Louis Flamand

Directeur de département

Louis Flamand
louis.flamand@fmed.ulaval.ca
Centre de recherche en infectiologie
Centre de recherche du CHU de Québec - Université Laval
Centre de recherche en arthrite (ARThrite)
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Immunologie-infectiologie

Domaines et intérêts de recherche du (de la) professeur(e) :

Maladies infectieuses et immunitaires
  • Virus
  • Infections virales
  • Maladies infectieuses
  • Défense cellulaire
  • Leucocytes
  • Antigènes

Projets de recherche

  • Dissecting the pathological consequences of neurological infections by herpesviruses, using human iPSC-derived cultures - Instituts de recherche en santé du Canada - Subvention Projet, University of Toronto, co-chercheur - 2021-04-01 au 2026-03-31
  • Pathogenic roles of platelets in sepsis - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2020-03-01 au 2025-03-31
  • Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
  • Pillar 2: In vitro and in vivo Characterizations - Coronavirus Variants Rapid Response Network: CoVaRR-Net - Instituts de recherche en santé du Canada - Subvention de fonctionnement:Réseau des IRSC pour la recherche sur les nouveaux variants du COVID-19, Université d'Ottawa, co-chercheur - 2021-03-01 au 2023-03-31
  • COVID-19 Vaccine in Immunosuppressed Adults with Autoimmune Diseases / La réponse immunitaire au vaccin contre la COVID-19 chez des patients immunosupprimés en raison de maladies auto-immunes - Ministère de la Santé et des Services sociaux, McGill University, co-chercheur - 2021-03-16 au 2023-03-31
  • Soutenir les démarches de diffusion de l'appel à candidature CERC - Équipe Louis Flamand - Université Laval - Fonds internes - BDR - Contributions, chercheur principal - 2022-04-01 au 2023-03-31
  • Human herpesvirus 6 and chromosomal integration - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2018-04-01 au 2023-03-31
  • The impact of antimalarial drugs in arthritis patients exposed to SARS-CoV-2- the CoVIRAL project - La société d'arthrite, co-chercheur - 2020-04-01 au 2023-03-31
  • Booster dose of mRNA SARS-CoV-2 vaccine vs non mRNA vaccine for people living with systemic autoimmune rhumatic diseases without adequate humoral response post standard mRNA vaccination - Instituts de recherche en santé du Canada - Subvention de fonctionnement:Nouveaux besoins prioritaires en recherche sur la COVID-19, co-chercheur - 2021-12-01 au 2022-11-30
  • Role of antibodies in platelet response to SARS-CoV-2 and its variants - Instituts de recherche en santé du Canada - Subvention de fonctionnement : Possibilité de financement sur les nouveaux besoins prioritaires en recherche sur la COVID-19, co-chercheur - 2021-07-01 au 2022-06-30
  • Pathogenesis and immune escape potential of SARS-CoV-2 variants of concern - Instituts de recherche en santé du Canada - Subvention de fonctionnement : Possibilité de financement sur les nouveaux besoins prioritaires en recherche sur la COVID-19, chercheur principal - 2021-06-01 au 2022-05-31
  • Role of platelets and their mother cell, the megakaryocyte, in COVID-19 - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2021-03-01 au 2022-02-28
  • Seeking for innovative approaches in prevention and cure to COVID-19 disease - Affinité instruments, Fondation Canadienne pour l'innovation (La), Ministère de l'Économie et de l'Innovation - Fonds des occasions exceptionnelles (FOE) – COVID-19, co-chercheur - 2020-11-01 au 2021-08-30
  • CanCOVID Network - Innovation, Sciences et Développement économique Canada, University of Toronto, co-chercheur - 2020-11-09 au 2021-06-24
  • COVID-19 trilogy: ARDS, inflammation and coagulopathy - Instituts de recherche en santé du Canada - Subvention de fonctionnement : Possibilité de financement pour une intervention de recherche rapide contre la COVID-19, chercheur principal - 2020-06-01 au 2021-05-31
  • Effect of cigarette smoke/e-cigarette vapor and SARS-CoV-2 infection on oral, nasal, and bronchial epithelial cell responses - Fonds de recherche du Québec - Santé - Réseaux thématiques de recherche, co-chercheur - 2020-04-01 au 2021-04-30
  • Understanding the pathogenesis of COVID-19 - Instituts de recherche en santé du Canada, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Subvention de fonctionnement : Possibilité de financement canadienne pour une intervention de recherche rapide contre la maladie à coronavirus 2019 (COVID-19), chercheur principal - 2020-03-01 au 2021-02-28

Publications

  • SARS-CoV-2 deregulates the vascular and immune functions of brain pericytes via Spike protein., , Neurobiology of disease, 2021, 10.1016/j.nbd.2021.105561
  • Platelet extracellular vesicles in COVID-19: Potential markers and makers., , Journal of leukocyte biology, 2021, 10.1002/jlb.3mir0221-100r
  • Variation in human herpesvirus 6B telomeric integration, excision, and transmission between tissues and individuals., Wood ML, Veal CD, Neumann R, Suárez NM, Nichols J, Parker AJ, Martin D, Romaine SP, Codd V, Samani NJ, Voors AA, Tomaszewski M, Flamand L, Davison AJ, Royle NJ, eLife, 2021, 10.7554/elife.70452
  • The immediate early protein 1 of the human herpesvirus 6B counteracts NBS1 and prevents homologous recombination repair pathways, Collin V, Biquand É, Tremblay V, Gaudreau-Lavoie É, Dessapt J, Gravel A, Flamand L, Fradet-Turcotte A, 2021, 10.1101/2021.07.31.454588
  • Chemokines and eicosanoids fuel the hyperinflammation within the lungs of patients with severe COVID-19., Zaid Y, Doré É, Dubuc I, Archambault AS, Flamand O, Laviolette M, Flamand N, Boilard É, Flamand L, The Journal of allergy and clinical immunology, 2021, 10.1016/j.jaci.2021.05.032
  • High levels of eicosanoids and docosanoids in the lungs of intubated COVID-19 patients., Archambault AS, Zaid Y, Rakotoarivelo V, Turcotte C, Doré É, Dubuc I, Martin C, Flamand O, Amar Y, Cheikh A, Fares H, El Hassani A, Tijani Y, Côté A, Flamand N, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021, 10.1096/fj.202100540r
  • Variation in Human Herpesvirus 6B telomeric integration, excision and transmission between tissues and individuals, Wood M, Veal C, Neumann R, Suárez N, Nichols J, Parker A, Martin D, Romaine S, Codd V, Samani N, Voors A, Tomaszewski M, Flamand L, Davison A, Royle N, 2021, 10.1101/2021.06.07.447326
  • Higher-Order Chromatin Structures of Chromosomally Integrated HHV-6A Predict Integration Sites., Mariani M, Zimmerman C, Rodriguez P, Hasenohr E, Aimola G, Gerrard DL, Richman A, Dest A, Flamand L, Kaufer B, Frietze S, Frontiers in cellular and infection microbiology, 2021, 10.3389/fcimb.2021.612656
  • Mapping the Human Herpesvirus 6B transcriptome., Gravel A, Sanders W, Fournier É, Droit A, Moorman N, Flamand L, Journal of virology, 2021, 10.1128/jvi.01335-20
  • Platelet reactivity to thrombin differs between patients with COVID-19 and those with ARDS unrelated to COVID-19., Zaid Y, Guessous F, Puhm F, Elhamdani W, Chentoufi L, Morris AC, Cheikh A, Jalali F, Boilard E, Flamand L, Blood advances, 2021, 10.1182/bloodadvances.2020003513
  • Antiviral Activity of the G-Quadruplex Ligand TMPyP4 against Herpes Simplex Virus-1, Sara Artusi, Emanuela Ruggiero, MATTEO NADAI, Beatrice Tosoni, Rosalba Perrone, Annalisa Ferino, Irene Zanin, Luigi XODO, Louis Flamand, Sara Richter, Viruses, 2021, 10.3390/v13020196
  • Lipid storm within the lungs of severe COVID-19 patients: Extensive levels of cyclooxygenase and lipoxygenase-derived inflammatory metabolites, Archambault A, Zaid Y, Rakotoarivelo V, Doré É, Dubuc I, Martin C, Amar Y, Cheikh A, Fares H, El Hassani A, Tijani Y, Laviolette M, Boilard É, Flamand N, 2020, 10.1101/2020.12.04.20242115
  • Platelets Can Associate with SARS-Cov-2 RNA and Are Hyperactivated in COVID-19., Zaid Y, Puhm F, Allaeys I, Naya A, Oudghiri M, Khalki L, Limami Y, Zaid N, Sadki K, Ben El Haj R, Mahir W, Belayachi L, Belefquih B, Benouda A, Boilard E, Circulation research, 2020, 10.1161/circresaha.120.317703
  • The Promyelocytic Leukemia Protein facilitates human herpesvirus 6B chromosomal integration, immediate-early 1 protein multiSUMOylation and its localization at telomeres., Collin V, Gravel A, Kaufer BB, Flamand L, PLoS pathogens, 2020, 10.1371/journal.ppat.1008683
  • Platelets can contain SARS-CoV-2 RNA and are hyperactivated in COVID-19, Zaid Y, Puhm F, Allaeys I, Naya A, Oudghiri M, Khalki L, Limami Y, Zaid N, Sadki K, El Haj RB, Maher W, Lamiae B, Belefquih B, Benouda A, Cheikh A, Boilard E, 2020, 10.1101/2020.06.23.20137596
  • Role for the shelterin protein TRF2 in human herpesvirus 6A/B chromosomal integration., Gilbert-Girard S, Gravel A, Collin V, Wight DJ, Kaufer BB, Lazzerini-Denchi E, Flamand L, PLoS pathogens, 2020, 10.1371/journal.ppat.1008496
  • rs73185306 C/T Is Not a Predisposing Risk Factor for Inherited Chromosomally Integrated Human Herpesvirus 6A/B., Mouammine A, Gravel A, Dubuc I, Feroz Zada Y, Provost S, Busseuil D, Tardif JC, Dubé MP, Flamand L, The Journal of infectious diseases, 2020, 10.1093/infdis/jiz527
  • Inherited Chromosomally Integrated Human Herpesvirus 6 Demonstrates Tissue-Specific RNA Expression In Vivo That Correlates with an Increased Antibody Immune Response., Peddu V, Dubuc I, Gravel A, Xie H, Huang ML, Tenenbaum D, Jerome KR, Tardif JC, Dubé MP, Flamand L, Greninger AL, Journal of virology, 2019, 10.1128/jvi.01418-19
  • Increased Serological Response Against Human Herpesvirus 6A Is Associated With Risk for Multiple Sclerosis., Engdahl E, Gustafsson R, Huang J, Biström M, Lima Bomfim I, Stridh P, Khademi M, Brenner N, Butt J, Michel A, Jons D, Hortlund M, Alonso-Magdalena L, Fogdell-Hahn A, Frontiers in immunology, 2019, 10.3389/fimmu.2019.02715
  • Summary of the 11th International Conference on Human Herpesviruses-6A, -6B, and -7., Komaroff AL, Zerr DM, Flamand L, Journal of medical virology, 2019, 10.1002/jmv.25576
  • Increased serological response against human herpesvirus 6A is associated with risk for multiple sclerosis, Engdahl E, Gustafsson R, Huang J, Biström M, Bomfim IL, Stridh P, Khademi M, Brenner N, Butt J, Michel A, Jons D, Hortlund M, Alonso-Magdalena L, Fogdell-Hahn A, 2019, 10.1101/737932
  • Inherited chromosomally integrated HHV-6 demonstrates tissue-specific RNA expressionin vivothat correlates with increased antibody immune response, Peddu V, Dubuc I, Gravel A, Xie H, Huang M, Tenenbaum D, Jerome KR, Tardif J, Dubé M, Flamand L, Greninger AL, 2019, 10.1101/741025
  • Chromatin Profiles of Chromosomally Integrated Human Herpesvirus-6A., Saviola AJ, Zimmermann C, Mariani MP, Signorelli SA, Gerrard DL, Boyd JR, Wight DJ, Morissette G, Gravel A, Dubuc I, Flamand L, Kaufer BB, Frietze S, Frontiers in microbiology, 2019, 10.3389/fmicb.2019.01408
  • The role of the megakaryocyte in immunity has gone viral., Boilard E, Flamand L, Blood, 2019, 10.1182/blood-2019-02-900787
  • Modulation and recruitment of TRF2 at viral telomeres during human herpesvirus 6A/B infection, Gilbert-Girard S, Gravel A, Collin V, Wight DJ, Kaufer BB, Lazzerini-Denchi E, Flamand L, 2019, 10.1101/514075
  • Viral Proteins U41 and U70 of Human Herpesvirus 6A Are Dispensable for Telomere Integration., Wight DJ, Wallaschek N, Sanyal A, Weller SK, Flamand L, Kaufer BB, Viruses, 2018, 10.3390/v10110656
  • Role of PML-Nuclear Bodies in Human Herpesvirus 6A and 6B Genome Integration, Collin V, Gravel A, Kaufer BB, Flamand L, 2018, 10.1101/413575
  • The ND10 Complex Represses Lytic Human Herpesvirus 6A Replication and Promotes Silencing of the Viral Genome., Sanyal A, Wallaschek N, Glass M, Flamand L, Wight DJ, Kaufer BB, Viruses, 2018, 10.3390/v10080401
  • Chromosomal Integration by Human Herpesviruses 6A and 6B., Flamand L, Advances in experimental medicine and biology, 2018, 10.1007/978-981-10-7230-7_10
  • Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration., Cloutier N, Allaeys I, Marcoux G, Machlus KR, Mailhot B, Zufferey A, Levesque T, Becker Y, Tessandier N, Melki I, Zhi H, Poirier G, Rondina MT, Boilard E, Proceedings of the National Academy of Sciences of the United States of America, 2018, 10.1073/pnas.1720553115
  • HHV-6A/B Integration and the Pathogenesis Associated with the Reactivation of Chromosomally Integrated HHV-6A/B, , Viruses, 2017, 10.3390/v9070160
  • Cell culture systems to study Human Herpesvirus 6A/B Chromosomal Integration, Annie Gravel, Isabelle Dubuc, Nina Wallaschek, Shella Gilbert-Girard, Vanessa Collin, Ruth Hall-Sedlak, Keith R. Jerome, Yasuko Mori, Julie Carbonneau, Guy Boivin, Benedikt B. Kaufer, Louis Flamand, Journal of Virology, 2017, 10.1128/jvi.00437-17
  • Stabilization of telomere G-quadruplexes interferes with human herpesvirus 6A chromosomal integration, Shella Gilbert-Girard, Annie Gravel, Sara Artusi, Sara N. Richter, Nina Wallaschek, Benedikt B. Kaufer, Louis Flamand, Journal of Virology, 2017, 10.1128/jvi.00402-17
  • Inherited Chromosomally Integrated Human Herpesvirus 6 and Breast Cancer, Annie Gravel, Isabelle Dubuc, Angela Brooks-Wilson, Kristan J. Aronson, Jacques Simard, Héctor A. Velásquez-García, John J. Spinelli, Louis Flamand, Cancer Epidemiology Biomarkers & Prevention, 2016, 10.1158/1055-9965.epi-16-0735
  • The putative U94 integrase is dispensable for human herpesvirus 6 (HHV-6) chromosomal integration, Nina Wallaschek, Annie Gravel, Louis Flamand, Benedikt B. Kaufer, Journal of General Virology, 2016, 10.1099/jgv.0.000502
  • Summary of the 9th international conference on human herpesviruses 6 and 7 (HHV-6A, HHV-6B, and HHV-7)., Komaroff AL, Phan T, Flamand L, Pellett PE, Journal of medical virology, 2016, 10.1002/jmv.24561
  • The Telomeric Repeats of Human Herpesvirus 6A (HHV-6A) Are Required for Efficient Virus Integration, Nina Wallaschek, Anirban Sanyal, Fabian Pirzer, Annie Gravel, Yasuko Mori, Louis Flamand, Benedikt B. Kaufer, PLOS Pathogens, 2016, 10.1371/journal.ppat.1005666
  • Detection of Human Herpesvirus 6B (HHV-6B) Reactivation in Hematopoietic Cell Transplant Recipients with Inherited Chromosomally Integrated HHV-6A by Droplet Digital PCR., Sedlak RH, Hill JA, Nguyen T, Cho M, Levin G, Cook L, Huang ML, Flamand L, Zerr DM, Boeckh M, Jerome KR, Journal of clinical microbiology, 2016, 10.1128/jcm.03275-15
  • Inherited chromosomally integrated human herpesvirus 6 as a predisposing risk factor for the development of angina pectoris., Gravel A, Dubuc I, Morissette G, Sedlak RH, Jerome KR, Flamand L, Proceedings of the National Academy of Sciences of the United States of America, 2015, 10.1073/pnas.1502741112
  • Characterization of human herpesvirus 6A/B U94 as ATPase, helicase, exonuclease and DNA-binding proteins, Frédéric Trempe, Annie Gravel, Isabelle Dubuc, Nina Wallaschek, Vanessa Collin, Shella Gilbert-Girard, Guillaume Morissette, Benedikt B. Kaufer, Louis Flamand, Nucleic Acids Research, 2015, 10.1093/nar/gkv503
  • The Herpes Simplex Virus-1 genome contains multiple clusters of repeated G-quadruplex: Implications for the antiviral activity of a G-quadruplex ligand., Artusi S, Nadai M, Perrone R, Biasolo MA, Palù G, Flamand L, Calistri A, Richter SN, Antiviral research, 2015, 10.1016/j.antiviral.2015.03.016
  • Chromosomally integrated HHV-6: impact on virus, cell and organismal biology., Kaufer BB, Flamand L, Current opinion in virology, 2014, 10.1016/j.coviro.2014.09.010
  • Human herpesvirus 6B immediate-early I protein contains functional HLA-A*02, HLA-A*03, and HLA-B*07 class I restricted CD8(+) T-cell epitopes., Iampietro M, Morissette G, Gravel A, Dubuc I, Rousseau M, Hasan A, O'Reilly RJ, Flamand L, European journal of immunology, 2014, 10.1002/eji.201444931
  • Inhibition of breast cancer cell proliferation through disturbance of the calcineurin/NFAT pathway by human herpesvirus 6B U54 tegument protein., Iampietro M, Gravel A, Flamand L, Journal of virology, 2014, 10.1128/jvi.02107-14
  • Inhibition of interleukin-2 gene expression by human herpesvirus 6B U54 tegument protein., Iampietro M, Morissette G, Gravel A, Flamand L, Journal of virology, 2014, 10.1128/jvi.02030-14
  • Pathogenesis from the reactivation of chromosomally integrated human herpesvirus type 6: facts rather than fiction., Flamand L, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2014, 10.1093/cid/ciu326
  • Influenza virus H1N1 activates platelets through FcγRIIA signaling and thrombin generation., Boilard E, Paré G, Rousseau M, Cloutier N, Dubuc I, Lévesque T, Borgeat P, Flamand L, Blood, 2014, 10.1182/blood-2013-07-515536
  • Chromosomally Integrated HHV-6, Mario Luppi, Leonardo Potenza, Guillaume Morissette, Louis Flamand, Human Herpesviruses HHV-6A, HHV-6B & HHV-7, 2014, 10.1016/b978-0-444-62703-2.00015-x
  • Frequency of chromosomally-integrated human herpesvirus 6 in children with acute lymphoblastic leukemia., Gravel A, Sinnett D, Flamand L, PloS one, 2013, 10.1371/journal.pone.0084322
  • Classification of HHV-6A and HHV-6B as distinct viruses., Ablashi D, Agut H, Alvarez-Lafuente R, Clark DA, Dewhurst S, DiLuca D, Flamand L, Frenkel N, Gallo R, Gompels UA, Höllsberg P, Jacobson S, Luppi M, Yoshikawa T, Archives of virology, 2013, 10.1007/s00705-013-1902-5
  • Randomized clinical trial to evaluate the efficacy and safety of valganciclovir in a subset of patients with chronic fatigue syndrome., Montoya JG, Kogelnik AM, Bhangoo M, Lunn MR, Flamand L, Merrihew LE, Watt T, Kubo JT, Paik J, Desai M, Journal of medical virology, 2013, 10.1002/jmv.23713
  • Complete Genome Sequence of Early Passaged Human Herpesvirus 6A (GS Strain) Isolated from North America., Gravel A, Ablashi D, Flamand L, Genome announcements, 2013, 10.1128/genomea.00012-13
  • Sequence analysis of transplacentally acquired human herpesvirus 6 DNA is consistent with transmission of a chromosomally integrated reactivated virus., Gravel A, Hall CB, Flamand L, The Journal of infectious diseases, 2013, 10.1093/infdis/jit060
  • 2-Arachidonoyl-glycerol- and arachidonic acid-stimulated neutrophils release antimicrobial effectors against E. coli, S. aureus, HSV-1, and RSV., Chouinard F, Turcotte C, Guan X, Larose MC, Poirier S, Bouchard L, Provost V, Flamand L, Grandvaux N, Flamand N, Journal of leukocyte biology, 2012, 10.1189/jlb.0412200
  • [Human herpesviruses HHV-6 and chromosomal integration: pathological and medical associated consequences]., Trempe F, Morissette G, Gravel A, Flamand L, Virologie (Montrouge, France), 2011, 10.1684/vir.2011.0428
  • Chromosomally integrated human herpesvirus 6: questions and answers., Pellett PE, Ablashi DV, Ambros PF, Agut H, Caserta MT, Descamps V, Flamand L, Gautheret-Dejean A, Hall CB, Kamble RT, Kuehl U, Lassner D, Razonable RR, Reviews in medical virology, 2011, 10.1002/rmv.715
  • Extra domain A of fibronectin primes leukotriene biosynthesis and stimulates neutrophil migration through activation of Toll-like receptor 4., Lefebvre JS, Lévesque T, Picard S, Paré G, Gravel A, Flamand L, Borgeat P, Arthritis and rheumatism, 2011, 10.1002/art.30308
  • LTB4 increases nasal neutrophil activity and conditions neutrophils to exert antiviral effects., Widegren H, Andersson M, Borgeat P, Flamand L, Johnston S, Greiff L, Respiratory medicine, 2011, 10.1016/j.rmed.2010.12.021
  • Serological and virological investigation of the role of the herpesviruses EBV, CMV and HHV-6 in post-infective fatigue syndrome., Cameron B, Flamand L, Juwana H, Middeldorp J, Naing Z, Rawlinson W, Ablashi D, Lloyd A, Journal of medical virology, 2010, 10.1002/jmv.21873
  • Herpesviruses and Chromosomal Integration, G. Morissette, L. Flamand, Journal of Virology, 2010, 10.1128/jvi.01169-10
  • Repression of interferon-α stimulated genes expression by Kaposi's sarcoma-associated herpesvirus K-bZIP protein., Lefort S, Gravel A, Flamand L, Virology, 2010, 10.1016/j.virol.2010.07.027
  • Review, part 1: Human herpesvirus-6-basic biology, diagnostic testing, and antiviral efficacy, Louis Flamand, Anthony L. Komaroff, Jesse H. Arbuckle, Peter G. Medveczky, Dharam V. Ablashi, Journal of Medical Virology, 2010, 10.1002/jmv.21839
  • Contagious period for pandemic (H1N1) 2009., De Serres G, Rouleau I, Hamelin ME, Quach C, Skowronski D, Flamand L, Boulianne N, Li Y, Carbonneau J, Bourgault A, Couillard M, Charest H, Boivin G, Emerging infectious diseases, 2010, 10.3201/eid1605.091894
  • Human herpesvirus-6 in patients with Crohn's disease., Sura R, Gavrilov B, Flamand L, Ablashi D, Cartun R, Colombel JF, Van Kruiningen HJ, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 2010, 10.1111/j.1600-0463.2010.02613.x
  • Association between the 2008-09 seasonal influenza vaccine and pandemic H1N1 illness during Spring-Summer 2009: four observational studies from Canada., Skowronski DM, De Serres G, Crowcroft NS, Janjua NZ, Boulianne N, Hottes TS, Rosella LC, Dickinson JA, Gilca R, Sethi P, Ouhoummane N, Willison DJ, Canadian SAVOIR Team, PLoS medicine, 2010, 10.1371/journal.pmed.1000258
  • Divergent susceptibilities of human herpesvirus 6 variants to type I interferons., Jaworska J, Gravel A, Flamand L, Proceedings of the National Academy of Sciences of the United States of America, 2010, 10.1073/pnas.0909951107
  • Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen inhibits interferon (IFN) beta expression by competing with IFN regulatory factor-3 for binding to IFNB promoter., Cloutier N, Flamand L, The Journal of biological chemistry, 2010, 10.1074/jbc.m109.018838
  • Amphipathic DNA polymers exhibit antiviral activity against systemic murine Cytomegalovirus infection., Cardin RD, Bravo FJ, Sewell AP, Cummins J, Flamand L, Juteau JM, Bernstein DI, Vaillant A, Virology journal, 2009, 10.1186/1743-422x-6-214
  • Divergent susceptibilities of human herpesvirus 6 variants to type I interferon, Joanna Jaworska, Louis Flamand, Cytokine, 2009, 10.1016/j.cyto.2009.07.310
  • Kaposi's sarcoma-associated herpesvirus K-bZIP protein is necessary for lytic viral gene expression, DNA replication, and virion production in primary effusion lymphoma cell lines., Lefort S, Flamand L, Journal of virology, 2009, 10.1128/jvi.01821-08
  • Multicenter Comparison of PCR Assays for Detection of Human Herpesvirus 6 DNA in Serum, Flamand L, Gravel A, Boutolleau D, Alvarez-Lafuente R, Jacobson S, Malnati M, Kohn D, Tang Y, Yoshikawa T, Ablashi D, Journal of clinical microbiology, 2009
  • Multicenter comparison of PCR assays for detection of human herpesvirus 6 DNA in serum., Flamand L, Gravel A, Boutolleau D, Alvarez-Lafuente R, Jacobson S, Malnati MS, Kohn D, Tang YW, Yoshikawa T, Ablashi D, Journal of clinical microbiology, 2008, 10.1128/jcm.00370-08
  • Identification of functional microRNAs released through asymmetrical processing of HIV-1 TAR element., Ouellet DL, Plante I, Landry P, Barat C, Janelle ME, Flamand L, Tremblay MJ, Provost P, Nucleic acids research, 2008, 10.1093/nar/gkn076
  • Normal human primary CD4+ T lymphocytes synthesize and release functional osteoprotegerin in vitro., Chakravarti A, Marceau AA, Flamand L, Poubelle PE, Laboratory investigation; a journal of technical methods and pathology, 2007, 10.1038/labinvest.3700701
  • Increased tumorigenicity of cells carrying recombinant human herpesvirus 8., Cloutier N, van Eyll O, Janelle ME, Lefort S, Gao SJ, Flamand L, Archives of virology, 2007, 10.1007/s00705-007-1072-4
  • Synergistic activation of interferon-beta gene transcription by the viral FLICE inhibitory protein of Kaposi's sarcoma-associated herpesvirus and type I IFN activators., Cloutier N, Grandvaux N, Flamand L, European journal of immunology, 2007, 10.1002/eji.200737181
  • Binding of Kaposi's sarcoma-associated herpesvirus K-bZIP to interferon-responsive factor 3 elements modulates antiviral gene expression., Lefort S, Soucy-Faulkner A, Grandvaux N, Flamand L, Journal of virology, 2007, 10.1128/jvi.00183-07
  • Leukotriene B4 triggers the in vitro and in vivo release of potent antimicrobial agents., Flamand L, Tremblay MJ, Borgeat P, Journal of immunology (Baltimore, Md. : 1950), 2007, 10.4049/jimmunol.178.12.8036
  • Inhibition of transcription of the beta interferon gene by the human herpesvirus 6 immediate-early 1 protein., Jaworska J, Gravel A, Fink K, Grandvaux N, Flamand L, Journal of virology, 2007, 10.1128/jvi.02443-06
  • Epitope mapping of a monoclonal antibody specific for human herpesvirus 6 variant A immediate-early 2 protein., Tomoiu A, Flamand L, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2007, 10.1016/j.jcv.2006.12.025
  • Functional interaction between human herpesvirus 6 immediate-early 2 protein and ubiquitin-conjugating enzyme 9 in the absence of sumoylation., Tomoiu A, Gravel A, Tanguay RM, Flamand L, Journal of virology, 2006, 10.1128/jvi.00375-06
  • Mapping of human herpesvirus 6 immediate-early 2 protein transactivation domains., Tomoiu A, Gravel A, Flamand L, Virology, 2006, 10.1016/j.virol.2006.06.030
  • Phenotypic alterations and survival of monocytes following infection by human herpesvirus-6., Janelle ME, Flamand L, Archives of virology, 2006, 10.1007/s00705-005-0715-6
  • Leukotriene B4 protects latently infected mice against murine cytomegalovirus reactivation following allogeneic transplantation., Gosselin J, Borgeat P, Flamand L, Journal of immunology (Baltimore, Md. : 1950), 2005, 10.4049/jimmunol.174.3.1587
  • Multiplex detection and quantitation of latent and lytic transcripts of human herpesvirus-8 using RNase Protection Assay., Cloutier N, Gravel A, Flamand L, Journal of virological methods, 2004, 10.1016/j.jviromet.2004.07.004
  • Characterization of human herpesvirus 6 variant B immediate-early 1 protein modifications by small ubiquitin-related modifiers., Gravel A, Dion V, Cloutier N, Gosselin J, Flamand L, The Journal of general virology, 2004, 10.1099/vir.0.19610-0
  • Release of anti-HIV mediators after administration of leukotriene B4 to humans., Flamand L, Borgeat P, Lalonde R, Gosselin J, The Journal of infectious diseases, 2004, 10.1086/386374
  • Characterization of the immediate-early 2 protein of human herpesvirus 6, a promiscuous transcriptional activator., Gravel A, Tomoiu A, Cloutier N, Gosselin J, Flamand L, Virology, 2003, 10.1016/s0042-6822(03)00007-2
  • Urinary metabolites of leukotriene B4 in the human subject., Berry KA, Borgeat P, Gosselin J, Flamand L, Murphy RC, The Journal of biological chemistry, 2003, 10.1074/jbc.m300856200
  • Generation and characterization of a monoclonal antibody specific for human herpesvirus 6 variant A immediate–early 2 protein, Suzie Arsenault, Annie Gravel, Jean Gosselin, Louis Flamand, Journal of Clinical Virology, 2003, 10.1016/s1386-6532(03)00050-7
  • Activation of monocyte cyclooxygenase-2 gene expression by human herpesvirus 6. Role for cyclic AMP-responsive element-binding protein and activator protein-1., Janelle ME, Gravel A, Gosselin J, Tremblay MJ, Flamand L, The Journal of biological chemistry, 2002, 10.1074/jbc.m203041200
  • Impaired protein kinase C activation/translocation in Epstein-Barr virus-infected monocytes., Tardif M, Savard M, Flamand L, Gosselin J, The Journal of biological chemistry, 2002, 10.1074/jbc.m109036200
  • Human Herpesvirus 6 immediate-early 1 protein is a sumoylated nuclear phosphoprotein colocalizing with promyelocytic leukemia protein-associated nuclear bodies., Gravel A, Gosselin J, Flamand L, The Journal of biological chemistry, 2002, 10.1074/jbc.m200836200
  • Epstein-Barr virus primes human polymorphonuclear leucocytes for the biosynthesis of leukotriene B4., Gosselin J, Savard M, Tardif M, Flamand L, Borgeat P, Clinical and experimental immunology, 2001, 10.1046/j.1365-2249.2001.01687.x
  • Human herpesvirus 8 viral FLICE-inhibitory protein inhibits Fas-mediated apoptosis through binding and prevention of procaspase-8 maturation., Bélanger C, Gravel A, Tomoiu A, Janelle ME, Gosselin J, Tremblay MJ, Flamand L, Journal of human virology, 2001
  • EBV suppresses prostaglandin E2 biosynthesis in human monocytes., Savard M, Bélanger C, Tremblay MJ, Dumais N, Flamand L, Borgeat P, Gosselin J, Journal of immunology (Baltimore, Md. : 1950), 2000, 10.4049/jimmunol.164.12.6467
  • Infection of primary human monocytes by Epstein-Barr virus., Savard M, Bélanger C, Tardif M, Gourde P, Flamand L, Gosselin J, Journal of virology, 2000, 10.1128/jvi.74.6.2612-2619.2000
  • Interleukin-15 as an activator of natural killer cell-mediated antiviral response., Gosselin J, TomoIu A, Gallo RC, Flamand L, Blood, 1999
  • CD4 promoter transactivation by human herpesvirus 6., Flamand L, Romerio F, Reitz MS, Gallo RC, Journal of virology, 1998, 10.1128/jvi.72.11.8797-8805.1998
  • Epstein-Barr virus infects and induces apoptosis in human neutrophils., Larochelle B, Flamand L, Gourde P, Beauchamp D, Gosselin J, Blood, 1998
  • Effects of a urinary factor from women in early pregnancy on HIV-1, SIV and associated disease., Lunardi-Iskandar Y, Bryant JL, Blattner WA, Hung CL, Flamand L, Gill P, Hermans P, Birken S, Gallo RC, Nature medicine, 1998, 10.1038/nm0498-428
  • Activation of CD8+ T lymphocytes through the T cell receptor turns on CD4 gene expression: implications for HIV pathogenesis., Flamand L, Crowley RW, Lusso P, Colombini-Hatch S, Margolis DM, Gallo RC, Proceedings of the National Academy of Sciences of the United States of America, 1998, 10.1073/pnas.95.6.3111
  • Association of human herpes virus 6 (HHV-6) with multiple sclerosis: increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA., Soldan SS, Berti R, Salem N, Secchiero P, Flamand L, Calabresi PA, Brennan MB, Maloni HW, McFarland HF, Lin HC, Patnaik M, Jacobson S, Nature medicine, 1997, 10.1038/nm1297-1394
  • Human Herpesvirus 7 induces CD4(+) T-cell death by two distinct mechanisms: necrotic lysis in productively infected cells and apoptosis in uninfected or nonproductively infected cells., Secchiero P, Flamand L, Gibellini D, Falcieri E, Robuffo I, Capitani S, Gallo RC, Zauli G, Blood, 1997
  • Human herpesvirus 7 induces the down-regulation of CD4 antigen in lymphoid T cells without affecting p56lck levels., Secchiero P, Gibellini D, Flamand L, Robuffo I, Marchisio M, Capitani S, Gallo RC, Zauli G, Journal of immunology (Baltimore, Md. : 1950), 1997
  • Absence of human herpesvirus 8 DNA sequences in neoplastic Kaposi's sarcoma cell lines., Flamand L, Zeman RA, Bryant JL, Lunardi-Iskandar Y, Gallo RC, Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association, 1996, 10.1097/00042560-199610010-00011
  • Cyclic AMP-responsive element-dependent activation of Epstein-Barr virus zebra promoter by human herpesvirus 6., Flamand L, Menezes J, Journal of virology, 1996, 10.1128/jvi.70.3.1784-1791.1996
  • Human herpesvirus-6 enhances natural killer cell cytotoxicity via IL-15., Flamand L, Stefanescu I, Menezes J, The Journal of clinical investigation, 1996, 10.1172/jci118557
  • Immunosuppressive effect of human herpesvirus 6 on T-cell functions: suppression of interleukin-2 synthesis and cell proliferation., Flamand L, Gosselin J, Stefanescu I, Ablashi D, Menezes J, Blood, 1995
  • Activation of the Epstein-Barr virus replicative cycle by human herpesvirus 6., Flamand L, Stefanescu I, Ablashi DV, Menezes J, Journal of virology, 1993, 10.1128/jvi.67.11.6768-6777.1993
  • Modulatory effects of Epstein-Barr, herpes simplex, and human herpes-6 viral infections and coinfections on cytokine synthesis. A comparative study., Gosselin J, Flamand L, D'Addario M, Hiscott J, Stefanescu I, Ablashi DV, Gallo RC, Menezes J, Journal of immunology (Baltimore, Md. : 1950), 1992
  • Infection of peripheral blood mononuclear cells by herpes simplex and Epstein-Barr viruses. Differential induction of interleukin 6 and tumor necrosis factor-alpha., Gosselin J, Flamand L, D'Addario M, Hiscott J, Menezes J, The Journal of clinical investigation, 1992, 10.1172/jci115789
  • Human herpesvirus 6 induces interleukin-1 beta and tumor necrosis factor alpha, but not interleukin-6, in peripheral blood mononuclear cell cultures., Flamand L, Gosselin J, D'Addario M, Hiscott J, Ablashi DV, Gallo RC, Menezes J, Journal of virology, 1991, 10.1128/jvi.65.9.5105-5110.1991
  • Inhibition of tumor necrosis factor-alpha transcription by Epstein-Barr virus., Gosselin J, Menezes J, D'Addario M, Hiscott J, Flamand L, Lamoureux G, Oth D, European journal of immunology, 1991, 10.1002/eji.1830210130
  • [Role of liposomes in the presentation of HIV envelope glycoprotein and the immune response in mice], Thibodeau L, Chagnon M, Flamand L, Oth D, Lachapelle L, Tremblay C, Montagnier L, Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie, 1989

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Sabrina Gentil - Maitrîse avec mémoire - En cours
  • Emile Lacasse - Maitrîse avec mémoire - En cours
  • Islem Hmida - Doctorat - En cours
  • Annabelle Mouammine - Post-doctorat - En cours
  • Shella Gilbert-Girard - Maitrîse avec mémoire - 2016/09
  • Vanessa Collin - Maitrîse avec mémoire - 2018/09

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Vice-décanat à la recherche et aux études supérieures
Pavillon Ferdinand-Vandry
Université Laval
1050, avenue de la Médecine,  local 4645
Québec, Québec G1V 0A6
Canada

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vdres@fmed.ulaval.ca
Téléphone 418 656-2690

Jacques Simard
Vice-doyen à la recherche et aux études supérieures
vice-doyen.recherche-et-etudes-superieures@fmed.ulaval.ca

Louise Laperrière
Adjointe au vice-doyen à la recherche et aux études supérieures
louise.laperriere@fmed.ulaval.ca 

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