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Centre de recherche du CHU de Québec - Université Laval
Centre de recherche en arthrite (ARThrite)
Partager la fiche :
Contribution à la recherche
Axe de recherche de l'Université Laval :
Santé et bien-être durables
Thématiques de recherche de la Faculté de
médecine :
Immunologie-infectiologie
Domaines et intérêts de recherche du (de la)
professeur(e) :
Maladies infectieuses et immunitaires
Virus
Infections virales
Maladies infectieuses
Défense cellulaire
Leucocytes
Antigènes
Projets de recherche
Dissecting the pathological consequences of neurological infections by herpesviruses, using human iPSC-derived cultures- Instituts de recherche en santé du Canada - Subvention Projet, University of Toronto, co-chercheur - 2021-04-01 au 2026-03-31
Pathogenic roles of platelets in sepsis- Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2020-03-01 au 2025-03-31
Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval- Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
Pillar 2: In vitro and in vivo Characterizations - Coronavirus Variants Rapid Response Network: CoVaRR-Net- Instituts de recherche en santé du Canada - Subvention de fonctionnement:Réseau des IRSC pour la recherche sur les nouveaux variants du COVID-19, Université d'Ottawa, co-chercheur - 2021-03-01 au 2023-03-31
COVID-19 Vaccine in Immunosuppressed Adults with Autoimmune Diseases / La réponse immunitaire au vaccin contre la COVID-19 chez des patients immunosupprimés en raison de maladies auto-immunes- Ministère de la Santé et des Services sociaux, McGill University, co-chercheur - 2021-03-16 au 2023-03-31
Soutenir les démarches de diffusion de l'appel à candidature CERC - Équipe Louis Flamand- Université Laval - Fonds internes - BDR - Contributions, chercheur principal - 2022-04-01 au 2023-03-31
Human herpesvirus 6 and chromosomal integration- Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2018-04-01 au 2023-03-31
The impact of antimalarial drugs in arthritis patients exposed to SARS-CoV-2- the CoVIRAL project- La société d'arthrite, co-chercheur - 2020-04-01 au 2023-03-31
Booster dose of mRNA SARS-CoV-2 vaccine vs non mRNA vaccine for people living with systemic autoimmune rhumatic diseases without adequate humoral response post standard mRNA vaccination- Instituts de recherche en santé du Canada - Subvention de fonctionnement:Nouveaux besoins prioritaires en recherche sur la COVID-19, co-chercheur - 2021-12-01 au 2022-11-30
Role of antibodies in platelet response to SARS-CoV-2 and its variants- Instituts de recherche en santé du Canada - Subvention de fonctionnement : Possibilité de financement sur les nouveaux besoins prioritaires en recherche sur la COVID-19, co-chercheur - 2021-07-01 au 2022-06-30
Pathogenesis and immune escape potential of SARS-CoV-2 variants of concern- Instituts de recherche en santé du Canada - Subvention de fonctionnement : Possibilité de financement sur les nouveaux besoins prioritaires en recherche sur la COVID-19, chercheur principal - 2021-06-01 au 2022-05-31
Role of platelets and their mother cell, the megakaryocyte, in COVID-19- Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2021-03-01 au 2022-02-28
Seeking for innovative approaches in prevention and cure to COVID-19 disease- Affinité instruments, Fondation Canadienne pour l'innovation (La), Ministère de l'Économie et de l'Innovation - Fonds des occasions exceptionnelles (FOE) – COVID-19, co-chercheur - 2020-11-01 au 2021-08-30
CanCOVID Network- Innovation, Sciences et Développement économique Canada, University of Toronto, co-chercheur - 2020-11-09 au 2021-06-24
COVID-19 trilogy: ARDS, inflammation and coagulopathy- Instituts de recherche en santé du Canada - Subvention de fonctionnement : Possibilité de financement pour une intervention de recherche rapide contre la COVID-19, chercheur principal - 2020-06-01 au 2021-05-31
Effect of cigarette smoke/e-cigarette vapor and SARS-CoV-2 infection on oral, nasal, and bronchial epithelial cell responses- Fonds de recherche du Québec - Santé - Réseaux thématiques de recherche, co-chercheur - 2020-04-01 au 2021-04-30
Understanding the pathogenesis of COVID-19- Instituts de recherche en santé du Canada, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Subvention de fonctionnement : Possibilité de financement canadienne pour une intervention de recherche rapide contre la maladie à coronavirus 2019 (COVID-19), chercheur principal - 2020-03-01 au 2021-02-28
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Publications
SARS-CoV-2 deregulates the vascular and immune functions of brain pericytes via Spike protein., , Neurobiology of disease, 2021, 10.1016/j.nbd.2021.105561
Platelet extracellular vesicles in COVID-19: Potential markers and makers., , Journal of leukocyte biology, 2021, 10.1002/jlb.3mir0221-100r
Variation in human herpesvirus 6B telomeric integration, excision, and transmission between tissues and individuals., Wood ML, Veal CD, Neumann R, Suárez NM, Nichols J, Parker AJ, Martin D, Romaine SP, Codd V, Samani NJ, Voors AA, Tomaszewski M, Flamand L, Davison AJ, Royle NJ, eLife, 2021, 10.7554/elife.70452
The immediate early protein 1 of the human herpesvirus 6B counteracts NBS1 and prevents homologous recombination repair pathways, Collin V, Biquand É, Tremblay V, Gaudreau-Lavoie É, Dessapt J, Gravel A, Flamand L, Fradet-Turcotte A, 2021, 10.1101/2021.07.31.454588
Chemokines and eicosanoids fuel the hyperinflammation within the lungs of patients with severe COVID-19., Zaid Y, Doré É, Dubuc I, Archambault AS, Flamand O, Laviolette M, Flamand N, Boilard É, Flamand L, The Journal of allergy and clinical immunology, 2021, 10.1016/j.jaci.2021.05.032
High levels of eicosanoids and docosanoids in the lungs of intubated COVID-19 patients., Archambault AS, Zaid Y, Rakotoarivelo V, Turcotte C, Doré É, Dubuc I, Martin C, Flamand O, Amar Y, Cheikh A, Fares H, El Hassani A, Tijani Y, Côté A, Flamand N, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021, 10.1096/fj.202100540r
Variation in Human Herpesvirus 6B telomeric integration, excision and transmission between tissues and individuals, Wood M, Veal C, Neumann R, Suárez N, Nichols J, Parker A, Martin D, Romaine S, Codd V, Samani N, Voors A, Tomaszewski M, Flamand L, Davison A, Royle N, 2021, 10.1101/2021.06.07.447326
Higher-Order Chromatin Structures of Chromosomally Integrated HHV-6A Predict Integration Sites., Mariani M, Zimmerman C, Rodriguez P, Hasenohr E, Aimola G, Gerrard DL, Richman A, Dest A, Flamand L, Kaufer B, Frietze S, Frontiers in cellular and infection microbiology, 2021, 10.3389/fcimb.2021.612656
Mapping the Human Herpesvirus 6B transcriptome., Gravel A, Sanders W, Fournier É, Droit A, Moorman N, Flamand L, Journal of virology, 2021, 10.1128/jvi.01335-20
Platelet reactivity to thrombin differs between patients with COVID-19 and those with ARDS unrelated to COVID-19., Zaid Y, Guessous F, Puhm F, Elhamdani W, Chentoufi L, Morris AC, Cheikh A, Jalali F, Boilard E, Flamand L, Blood advances, 2021, 10.1182/bloodadvances.2020003513
Antiviral Activity of the G-Quadruplex Ligand TMPyP4 against Herpes Simplex Virus-1, Sara Artusi, Emanuela Ruggiero, MATTEO NADAI, Beatrice Tosoni, Rosalba Perrone, Annalisa Ferino, Irene Zanin, Luigi XODO, Louis Flamand, Sara Richter, Viruses, 2021, 10.3390/v13020196
Lipid storm within the lungs of severe COVID-19 patients: Extensive levels of cyclooxygenase and lipoxygenase-derived inflammatory metabolites, Archambault A, Zaid Y, Rakotoarivelo V, Doré É, Dubuc I, Martin C, Amar Y, Cheikh A, Fares H, El Hassani A, Tijani Y, Laviolette M, Boilard É, Flamand N, 2020, 10.1101/2020.12.04.20242115
Platelets Can Associate with SARS-Cov-2 RNA and Are Hyperactivated in COVID-19., Zaid Y, Puhm F, Allaeys I, Naya A, Oudghiri M, Khalki L, Limami Y, Zaid N, Sadki K, Ben El Haj R, Mahir W, Belayachi L, Belefquih B, Benouda A, Boilard E, Circulation research, 2020, 10.1161/circresaha.120.317703
The Promyelocytic Leukemia Protein facilitates human herpesvirus 6B chromosomal integration, immediate-early 1 protein multiSUMOylation and its localization at telomeres., Collin V, Gravel A, Kaufer BB, Flamand L, PLoS pathogens, 2020, 10.1371/journal.ppat.1008683
Platelets can contain SARS-CoV-2 RNA and are hyperactivated in COVID-19, Zaid Y, Puhm F, Allaeys I, Naya A, Oudghiri M, Khalki L, Limami Y, Zaid N, Sadki K, El Haj RB, Maher W, Lamiae B, Belefquih B, Benouda A, Cheikh A, Boilard E, 2020, 10.1101/2020.06.23.20137596
Role for the shelterin protein TRF2 in human herpesvirus 6A/B chromosomal integration., Gilbert-Girard S, Gravel A, Collin V, Wight DJ, Kaufer BB, Lazzerini-Denchi E, Flamand L, PLoS pathogens, 2020, 10.1371/journal.ppat.1008496
rs73185306 C/T Is Not a Predisposing Risk Factor for Inherited Chromosomally Integrated Human Herpesvirus 6A/B., Mouammine A, Gravel A, Dubuc I, Feroz Zada Y, Provost S, Busseuil D, Tardif JC, Dubé MP, Flamand L, The Journal of infectious diseases, 2020, 10.1093/infdis/jiz527
Inherited Chromosomally Integrated Human Herpesvirus 6 Demonstrates Tissue-Specific RNA Expression In Vivo That Correlates with an Increased Antibody Immune Response., Peddu V, Dubuc I, Gravel A, Xie H, Huang ML, Tenenbaum D, Jerome KR, Tardif JC, Dubé MP, Flamand L, Greninger AL, Journal of virology, 2019, 10.1128/jvi.01418-19
Increased Serological Response Against Human Herpesvirus 6A Is Associated With Risk for Multiple Sclerosis., Engdahl E, Gustafsson R, Huang J, Biström M, Lima Bomfim I, Stridh P, Khademi M, Brenner N, Butt J, Michel A, Jons D, Hortlund M, Alonso-Magdalena L, Fogdell-Hahn A, Frontiers in immunology, 2019, 10.3389/fimmu.2019.02715
Summary of the 11th International Conference on Human Herpesviruses-6A, -6B, and -7., Komaroff AL, Zerr DM, Flamand L, Journal of medical virology, 2019, 10.1002/jmv.25576
Increased serological response against human herpesvirus 6A is associated with risk for multiple sclerosis, Engdahl E, Gustafsson R, Huang J, Biström M, Bomfim IL, Stridh P, Khademi M, Brenner N, Butt J, Michel A, Jons D, Hortlund M, Alonso-Magdalena L, Fogdell-Hahn A, 2019, 10.1101/737932
Inherited chromosomally integrated HHV-6 demonstrates tissue-specific RNA expressionin vivothat correlates with increased antibody immune response, Peddu V, Dubuc I, Gravel A, Xie H, Huang M, Tenenbaum D, Jerome KR, Tardif J, Dubé M, Flamand L, Greninger AL, 2019, 10.1101/741025
Chromatin Profiles of Chromosomally Integrated Human Herpesvirus-6A., Saviola AJ, Zimmermann C, Mariani MP, Signorelli SA, Gerrard DL, Boyd JR, Wight DJ, Morissette G, Gravel A, Dubuc I, Flamand L, Kaufer BB, Frietze S, Frontiers in microbiology, 2019, 10.3389/fmicb.2019.01408
The role of the megakaryocyte in immunity has gone viral., Boilard E, Flamand L, Blood, 2019, 10.1182/blood-2019-02-900787
Modulation and recruitment of TRF2 at viral telomeres during human herpesvirus 6A/B infection, Gilbert-Girard S, Gravel A, Collin V, Wight DJ, Kaufer BB, Lazzerini-Denchi E, Flamand L, 2019, 10.1101/514075
Viral Proteins U41 and U70 of Human Herpesvirus 6A Are Dispensable for Telomere Integration., Wight DJ, Wallaschek N, Sanyal A, Weller SK, Flamand L, Kaufer BB, Viruses, 2018, 10.3390/v10110656
Role of PML-Nuclear Bodies in Human Herpesvirus 6A and 6B Genome Integration, Collin V, Gravel A, Kaufer BB, Flamand L, 2018, 10.1101/413575
The ND10 Complex Represses Lytic Human Herpesvirus 6A Replication and Promotes Silencing of the Viral Genome., Sanyal A, Wallaschek N, Glass M, Flamand L, Wight DJ, Kaufer BB, Viruses, 2018, 10.3390/v10080401
Chromosomal Integration by Human Herpesviruses 6A and 6B., Flamand L, Advances in experimental medicine and biology, 2018, 10.1007/978-981-10-7230-7_10
Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration., Cloutier N, Allaeys I, Marcoux G, Machlus KR, Mailhot B, Zufferey A, Levesque T, Becker Y, Tessandier N, Melki I, Zhi H, Poirier G, Rondina MT, Boilard E, Proceedings of the National Academy of Sciences of the United States of America, 2018, 10.1073/pnas.1720553115
HHV-6A/B Integration and the Pathogenesis Associated with the Reactivation of Chromosomally Integrated HHV-6A/B, , Viruses, 2017, 10.3390/v9070160
Cell culture systems to study Human Herpesvirus 6A/B Chromosomal Integration, Annie Gravel, Isabelle Dubuc, Nina Wallaschek, Shella Gilbert-Girard, Vanessa Collin, Ruth Hall-Sedlak, Keith R. Jerome, Yasuko Mori, Julie Carbonneau, Guy Boivin, Benedikt B. Kaufer, Louis Flamand, Journal of Virology, 2017, 10.1128/jvi.00437-17
Stabilization of telomere G-quadruplexes interferes with human herpesvirus 6A chromosomal integration, Shella Gilbert-Girard, Annie Gravel, Sara Artusi, Sara N. Richter, Nina Wallaschek, Benedikt B. Kaufer, Louis Flamand, Journal of Virology, 2017, 10.1128/jvi.00402-17
Inherited Chromosomally Integrated Human Herpesvirus 6 and Breast Cancer, Annie Gravel, Isabelle Dubuc, Angela Brooks-Wilson, Kristan J. Aronson, Jacques Simard, Héctor A. Velásquez-García, John J. Spinelli, Louis Flamand, Cancer Epidemiology Biomarkers & Prevention, 2016, 10.1158/1055-9965.epi-16-0735
The putative U94 integrase is dispensable for human herpesvirus 6 (HHV-6) chromosomal integration, Nina Wallaschek, Annie Gravel, Louis Flamand, Benedikt B. Kaufer, Journal of General Virology, 2016, 10.1099/jgv.0.000502
Summary of the 9th international conference on human herpesviruses 6 and 7 (HHV-6A, HHV-6B, and HHV-7)., Komaroff AL, Phan T, Flamand L, Pellett PE, Journal of medical virology, 2016, 10.1002/jmv.24561
The Telomeric Repeats of Human Herpesvirus 6A (HHV-6A) Are Required for Efficient Virus Integration, Nina Wallaschek, Anirban Sanyal, Fabian Pirzer, Annie Gravel, Yasuko Mori, Louis Flamand, Benedikt B. Kaufer, PLOS Pathogens, 2016, 10.1371/journal.ppat.1005666
Detection of Human Herpesvirus 6B (HHV-6B) Reactivation in Hematopoietic Cell Transplant Recipients with Inherited Chromosomally Integrated HHV-6A by Droplet Digital PCR., Sedlak RH, Hill JA, Nguyen T, Cho M, Levin G, Cook L, Huang ML, Flamand L, Zerr DM, Boeckh M, Jerome KR, Journal of clinical microbiology, 2016, 10.1128/jcm.03275-15
Inherited chromosomally integrated human herpesvirus 6 as a predisposing risk factor for the development of angina pectoris., Gravel A, Dubuc I, Morissette G, Sedlak RH, Jerome KR, Flamand L, Proceedings of the National Academy of Sciences of the United States of America, 2015, 10.1073/pnas.1502741112
Characterization of human herpesvirus 6A/B U94 as ATPase, helicase, exonuclease and DNA-binding proteins, Frédéric Trempe, Annie Gravel, Isabelle Dubuc, Nina Wallaschek, Vanessa Collin, Shella Gilbert-Girard, Guillaume Morissette, Benedikt B. Kaufer, Louis Flamand, Nucleic Acids Research, 2015, 10.1093/nar/gkv503
The Herpes Simplex Virus-1 genome contains multiple clusters of repeated G-quadruplex: Implications for the antiviral activity of a G-quadruplex ligand., Artusi S, Nadai M, Perrone R, Biasolo MA, Palù G, Flamand L, Calistri A, Richter SN, Antiviral research, 2015, 10.1016/j.antiviral.2015.03.016
Chromosomally integrated HHV-6: impact on virus, cell and organismal biology., Kaufer BB, Flamand L, Current opinion in virology, 2014, 10.1016/j.coviro.2014.09.010
Human herpesvirus 6B immediate-early I protein contains functional HLA-A*02, HLA-A*03, and HLA-B*07 class I restricted CD8(+) T-cell epitopes., Iampietro M, Morissette G, Gravel A, Dubuc I, Rousseau M, Hasan A, O'Reilly RJ, Flamand L, European journal of immunology, 2014, 10.1002/eji.201444931
Inhibition of breast cancer cell proliferation through disturbance of the calcineurin/NFAT pathway by human herpesvirus 6B U54 tegument protein., Iampietro M, Gravel A, Flamand L, Journal of virology, 2014, 10.1128/jvi.02107-14
Inhibition of interleukin-2 gene expression by human herpesvirus 6B U54 tegument protein., Iampietro M, Morissette G, Gravel A, Flamand L, Journal of virology, 2014, 10.1128/jvi.02030-14
Pathogenesis from the reactivation of chromosomally integrated human herpesvirus type 6: facts rather than fiction., Flamand L, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2014, 10.1093/cid/ciu326
Influenza virus H1N1 activates platelets through FcγRIIA signaling and thrombin generation., Boilard E, Paré G, Rousseau M, Cloutier N, Dubuc I, Lévesque T, Borgeat P, Flamand L, Blood, 2014, 10.1182/blood-2013-07-515536
Chromosomally Integrated HHV-6, Mario Luppi, Leonardo Potenza, Guillaume Morissette, Louis Flamand, Human Herpesviruses HHV-6A, HHV-6B & HHV-7, 2014, 10.1016/b978-0-444-62703-2.00015-x
Frequency of chromosomally-integrated human herpesvirus 6 in children with acute lymphoblastic leukemia., Gravel A, Sinnett D, Flamand L, PloS one, 2013, 10.1371/journal.pone.0084322
Classification of HHV-6A and HHV-6B as distinct viruses., Ablashi D, Agut H, Alvarez-Lafuente R, Clark DA, Dewhurst S, DiLuca D, Flamand L, Frenkel N, Gallo R, Gompels UA, Höllsberg P, Jacobson S, Luppi M, Yoshikawa T, Archives of virology, 2013, 10.1007/s00705-013-1902-5
Randomized clinical trial to evaluate the efficacy and safety of valganciclovir in a subset of patients with chronic fatigue syndrome., Montoya JG, Kogelnik AM, Bhangoo M, Lunn MR, Flamand L, Merrihew LE, Watt T, Kubo JT, Paik J, Desai M, Journal of medical virology, 2013, 10.1002/jmv.23713
Complete Genome Sequence of Early Passaged Human Herpesvirus 6A (GS Strain) Isolated from North America., Gravel A, Ablashi D, Flamand L, Genome announcements, 2013, 10.1128/genomea.00012-13
Sequence analysis of transplacentally acquired human herpesvirus 6 DNA is consistent with transmission of a chromosomally integrated reactivated virus., Gravel A, Hall CB, Flamand L, The Journal of infectious diseases, 2013, 10.1093/infdis/jit060
2-Arachidonoyl-glycerol- and arachidonic acid-stimulated neutrophils release antimicrobial effectors against E. coli, S. aureus, HSV-1, and RSV., Chouinard F, Turcotte C, Guan X, Larose MC, Poirier S, Bouchard L, Provost V, Flamand L, Grandvaux N, Flamand N, Journal of leukocyte biology, 2012, 10.1189/jlb.0412200
[Human herpesviruses HHV-6 and chromosomal integration: pathological and medical associated consequences]., Trempe F, Morissette G, Gravel A, Flamand L, Virologie (Montrouge, France), 2011, 10.1684/vir.2011.0428
Chromosomally integrated human herpesvirus 6: questions and answers., Pellett PE, Ablashi DV, Ambros PF, Agut H, Caserta MT, Descamps V, Flamand L, Gautheret-Dejean A, Hall CB, Kamble RT, Kuehl U, Lassner D, Razonable RR, Reviews in medical virology, 2011, 10.1002/rmv.715
Extra domain A of fibronectin primes leukotriene biosynthesis and stimulates neutrophil migration through activation of Toll-like receptor 4., Lefebvre JS, Lévesque T, Picard S, Paré G, Gravel A, Flamand L, Borgeat P, Arthritis and rheumatism, 2011, 10.1002/art.30308
LTB4 increases nasal neutrophil activity and conditions neutrophils to exert antiviral effects., Widegren H, Andersson M, Borgeat P, Flamand L, Johnston S, Greiff L, Respiratory medicine, 2011, 10.1016/j.rmed.2010.12.021
Serological and virological investigation of the role of the herpesviruses EBV, CMV and HHV-6 in post-infective fatigue syndrome., Cameron B, Flamand L, Juwana H, Middeldorp J, Naing Z, Rawlinson W, Ablashi D, Lloyd A, Journal of medical virology, 2010, 10.1002/jmv.21873
Herpesviruses and Chromosomal Integration, G. Morissette, L. Flamand, Journal of Virology, 2010, 10.1128/jvi.01169-10
Repression of interferon-α stimulated genes expression by Kaposi's sarcoma-associated herpesvirus K-bZIP protein., Lefort S, Gravel A, Flamand L, Virology, 2010, 10.1016/j.virol.2010.07.027
Review, part 1: Human herpesvirus-6-basic biology, diagnostic testing, and antiviral efficacy, Louis Flamand, Anthony L. Komaroff, Jesse H. Arbuckle, Peter G. Medveczky, Dharam V. Ablashi, Journal of Medical Virology, 2010, 10.1002/jmv.21839
Contagious period for pandemic (H1N1) 2009., De Serres G, Rouleau I, Hamelin ME, Quach C, Skowronski D, Flamand L, Boulianne N, Li Y, Carbonneau J, Bourgault A, Couillard M, Charest H, Boivin G, Emerging infectious diseases, 2010, 10.3201/eid1605.091894
Human herpesvirus-6 in patients with Crohn's disease., Sura R, Gavrilov B, Flamand L, Ablashi D, Cartun R, Colombel JF, Van Kruiningen HJ, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 2010, 10.1111/j.1600-0463.2010.02613.x
Association between the 2008-09 seasonal influenza vaccine and pandemic H1N1 illness during Spring-Summer 2009: four observational studies from Canada., Skowronski DM, De Serres G, Crowcroft NS, Janjua NZ, Boulianne N, Hottes TS, Rosella LC, Dickinson JA, Gilca R, Sethi P, Ouhoummane N, Willison DJ, Canadian SAVOIR Team, PLoS medicine, 2010, 10.1371/journal.pmed.1000258
Divergent susceptibilities of human herpesvirus 6 variants to type I interferons., Jaworska J, Gravel A, Flamand L, Proceedings of the National Academy of Sciences of the United States of America, 2010, 10.1073/pnas.0909951107
Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen inhibits interferon (IFN) beta expression by competing with IFN regulatory factor-3 for binding to IFNB promoter., Cloutier N, Flamand L, The Journal of biological chemistry, 2010, 10.1074/jbc.m109.018838
Divergent susceptibilities of human herpesvirus 6 variants to type I interferon, Joanna Jaworska, Louis Flamand, Cytokine, 2009, 10.1016/j.cyto.2009.07.310
Kaposi's sarcoma-associated herpesvirus K-bZIP protein is necessary for lytic viral gene expression, DNA replication, and virion production in primary effusion lymphoma cell lines., Lefort S, Flamand L, Journal of virology, 2009, 10.1128/jvi.01821-08
Multicenter Comparison of PCR Assays for Detection of Human Herpesvirus 6 DNA in Serum, Flamand L, Gravel A, Boutolleau D, Alvarez-Lafuente R, Jacobson S, Malnati M, Kohn D, Tang Y, Yoshikawa T, Ablashi D, Journal of clinical microbiology, 2009
Multicenter comparison of PCR assays for detection of human herpesvirus 6 DNA in serum., Flamand L, Gravel A, Boutolleau D, Alvarez-Lafuente R, Jacobson S, Malnati MS, Kohn D, Tang YW, Yoshikawa T, Ablashi D, Journal of clinical microbiology, 2008, 10.1128/jcm.00370-08
Identification of functional microRNAs released through asymmetrical processing of HIV-1 TAR element., Ouellet DL, Plante I, Landry P, Barat C, Janelle ME, Flamand L, Tremblay MJ, Provost P, Nucleic acids research, 2008, 10.1093/nar/gkn076
Normal human primary CD4+ T lymphocytes synthesize and release functional osteoprotegerin in vitro., Chakravarti A, Marceau AA, Flamand L, Poubelle PE, Laboratory investigation; a journal of technical methods and pathology, 2007, 10.1038/labinvest.3700701
Increased tumorigenicity of cells carrying recombinant human herpesvirus 8., Cloutier N, van Eyll O, Janelle ME, Lefort S, Gao SJ, Flamand L, Archives of virology, 2007, 10.1007/s00705-007-1072-4
Synergistic activation of interferon-beta gene transcription by the viral FLICE inhibitory protein of Kaposi's sarcoma-associated herpesvirus and type I IFN activators., Cloutier N, Grandvaux N, Flamand L, European journal of immunology, 2007, 10.1002/eji.200737181
Binding of Kaposi's sarcoma-associated herpesvirus K-bZIP to interferon-responsive factor 3 elements modulates antiviral gene expression., Lefort S, Soucy-Faulkner A, Grandvaux N, Flamand L, Journal of virology, 2007, 10.1128/jvi.00183-07
Leukotriene B4 triggers the in vitro and in vivo release of potent antimicrobial agents., Flamand L, Tremblay MJ, Borgeat P, Journal of immunology (Baltimore, Md. : 1950), 2007, 10.4049/jimmunol.178.12.8036
Inhibition of transcription of the beta interferon gene by the human herpesvirus 6 immediate-early 1 protein., Jaworska J, Gravel A, Fink K, Grandvaux N, Flamand L, Journal of virology, 2007, 10.1128/jvi.02443-06
Epitope mapping of a monoclonal antibody specific for human herpesvirus 6 variant A immediate-early 2 protein., Tomoiu A, Flamand L, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2007, 10.1016/j.jcv.2006.12.025
Functional interaction between human herpesvirus 6 immediate-early 2 protein and ubiquitin-conjugating enzyme 9 in the absence of sumoylation., Tomoiu A, Gravel A, Tanguay RM, Flamand L, Journal of virology, 2006, 10.1128/jvi.00375-06
Mapping of human herpesvirus 6 immediate-early 2 protein transactivation domains., Tomoiu A, Gravel A, Flamand L, Virology, 2006, 10.1016/j.virol.2006.06.030
Phenotypic alterations and survival of monocytes following infection by human herpesvirus-6., Janelle ME, Flamand L, Archives of virology, 2006, 10.1007/s00705-005-0715-6
Leukotriene B4 protects latently infected mice against murine cytomegalovirus reactivation following allogeneic transplantation., Gosselin J, Borgeat P, Flamand L, Journal of immunology (Baltimore, Md. : 1950), 2005, 10.4049/jimmunol.174.3.1587
Multiplex detection and quantitation of latent and lytic transcripts of human herpesvirus-8 using RNase Protection Assay., Cloutier N, Gravel A, Flamand L, Journal of virological methods, 2004, 10.1016/j.jviromet.2004.07.004
Characterization of human herpesvirus 6 variant B immediate-early 1 protein modifications by small ubiquitin-related modifiers., Gravel A, Dion V, Cloutier N, Gosselin J, Flamand L, The Journal of general virology, 2004, 10.1099/vir.0.19610-0
Release of anti-HIV mediators after administration of leukotriene B4 to humans., Flamand L, Borgeat P, Lalonde R, Gosselin J, The Journal of infectious diseases, 2004, 10.1086/386374
Characterization of the immediate-early 2 protein of human herpesvirus 6, a promiscuous transcriptional activator., Gravel A, Tomoiu A, Cloutier N, Gosselin J, Flamand L, Virology, 2003, 10.1016/s0042-6822(03)00007-2
Urinary metabolites of leukotriene B4 in the human subject., Berry KA, Borgeat P, Gosselin J, Flamand L, Murphy RC, The Journal of biological chemistry, 2003, 10.1074/jbc.m300856200
Generation and characterization of a monoclonal antibody specific for human herpesvirus 6 variant A immediate–early 2 protein, Suzie Arsenault, Annie Gravel, Jean Gosselin, Louis Flamand, Journal of Clinical Virology, 2003, 10.1016/s1386-6532(03)00050-7
Activation of monocyte cyclooxygenase-2 gene expression by human herpesvirus 6. Role for cyclic AMP-responsive element-binding protein and activator protein-1., Janelle ME, Gravel A, Gosselin J, Tremblay MJ, Flamand L, The Journal of biological chemistry, 2002, 10.1074/jbc.m203041200
Impaired protein kinase C activation/translocation in Epstein-Barr virus-infected monocytes., Tardif M, Savard M, Flamand L, Gosselin J, The Journal of biological chemistry, 2002, 10.1074/jbc.m109036200
Human Herpesvirus 6 immediate-early 1 protein is a sumoylated nuclear phosphoprotein colocalizing with promyelocytic leukemia protein-associated nuclear bodies., Gravel A, Gosselin J, Flamand L, The Journal of biological chemistry, 2002, 10.1074/jbc.m200836200
Epstein-Barr virus primes human polymorphonuclear leucocytes for the biosynthesis of leukotriene B4., Gosselin J, Savard M, Tardif M, Flamand L, Borgeat P, Clinical and experimental immunology, 2001, 10.1046/j.1365-2249.2001.01687.x
Human herpesvirus 8 viral FLICE-inhibitory protein inhibits Fas-mediated apoptosis through binding and prevention of procaspase-8 maturation., Bélanger C, Gravel A, Tomoiu A, Janelle ME, Gosselin J, Tremblay MJ, Flamand L, Journal of human virology, 2001
EBV suppresses prostaglandin E2 biosynthesis in human monocytes., Savard M, Bélanger C, Tremblay MJ, Dumais N, Flamand L, Borgeat P, Gosselin J, Journal of immunology (Baltimore, Md. : 1950), 2000, 10.4049/jimmunol.164.12.6467
Infection of primary human monocytes by Epstein-Barr virus., Savard M, Bélanger C, Tardif M, Gourde P, Flamand L, Gosselin J, Journal of virology, 2000, 10.1128/jvi.74.6.2612-2619.2000
Interleukin-15 as an activator of natural killer cell-mediated antiviral response., Gosselin J, TomoIu A, Gallo RC, Flamand L, Blood, 1999
CD4 promoter transactivation by human herpesvirus 6., Flamand L, Romerio F, Reitz MS, Gallo RC, Journal of virology, 1998, 10.1128/jvi.72.11.8797-8805.1998
Epstein-Barr virus infects and induces apoptosis in human neutrophils., Larochelle B, Flamand L, Gourde P, Beauchamp D, Gosselin J, Blood, 1998
Effects of a urinary factor from women in early pregnancy on HIV-1, SIV and associated disease., Lunardi-Iskandar Y, Bryant JL, Blattner WA, Hung CL, Flamand L, Gill P, Hermans P, Birken S, Gallo RC, Nature medicine, 1998, 10.1038/nm0498-428
Activation of CD8+ T lymphocytes through the T cell receptor turns on CD4 gene expression: implications for HIV pathogenesis., Flamand L, Crowley RW, Lusso P, Colombini-Hatch S, Margolis DM, Gallo RC, Proceedings of the National Academy of Sciences of the United States of America, 1998, 10.1073/pnas.95.6.3111
Association of human herpes virus 6 (HHV-6) with multiple sclerosis: increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA., Soldan SS, Berti R, Salem N, Secchiero P, Flamand L, Calabresi PA, Brennan MB, Maloni HW, McFarland HF, Lin HC, Patnaik M, Jacobson S, Nature medicine, 1997, 10.1038/nm1297-1394
Human Herpesvirus 7 induces CD4(+) T-cell death by two distinct mechanisms: necrotic lysis in productively infected cells and apoptosis in uninfected or nonproductively infected cells., Secchiero P, Flamand L, Gibellini D, Falcieri E, Robuffo I, Capitani S, Gallo RC, Zauli G, Blood, 1997
Human herpesvirus 7 induces the down-regulation of CD4 antigen in lymphoid T cells without affecting p56lck levels., Secchiero P, Gibellini D, Flamand L, Robuffo I, Marchisio M, Capitani S, Gallo RC, Zauli G, Journal of immunology (Baltimore, Md. : 1950), 1997
Absence of human herpesvirus 8 DNA sequences in neoplastic Kaposi's sarcoma cell lines., Flamand L, Zeman RA, Bryant JL, Lunardi-Iskandar Y, Gallo RC, Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association, 1996, 10.1097/00042560-199610010-00011
Cyclic AMP-responsive element-dependent activation of Epstein-Barr virus zebra promoter by human herpesvirus 6., Flamand L, Menezes J, Journal of virology, 1996, 10.1128/jvi.70.3.1784-1791.1996
Human herpesvirus-6 enhances natural killer cell cytotoxicity via IL-15., Flamand L, Stefanescu I, Menezes J, The Journal of clinical investigation, 1996, 10.1172/jci118557
Immunosuppressive effect of human herpesvirus 6 on T-cell functions: suppression of interleukin-2 synthesis and cell proliferation., Flamand L, Gosselin J, Stefanescu I, Ablashi D, Menezes J, Blood, 1995
Activation of the Epstein-Barr virus replicative cycle by human herpesvirus 6., Flamand L, Stefanescu I, Ablashi DV, Menezes J, Journal of virology, 1993, 10.1128/jvi.67.11.6768-6777.1993
Modulatory effects of Epstein-Barr, herpes simplex, and human herpes-6 viral infections and coinfections on cytokine synthesis. A comparative study., Gosselin J, Flamand L, D'Addario M, Hiscott J, Stefanescu I, Ablashi DV, Gallo RC, Menezes J, Journal of immunology (Baltimore, Md. : 1950), 1992
Infection of peripheral blood mononuclear cells by herpes simplex and Epstein-Barr viruses. Differential induction of interleukin 6 and tumor necrosis factor-alpha., Gosselin J, Flamand L, D'Addario M, Hiscott J, Menezes J, The Journal of clinical investigation, 1992, 10.1172/jci115789
Human herpesvirus 6 induces interleukin-1 beta and tumor necrosis factor alpha, but not interleukin-6, in peripheral blood mononuclear cell cultures., Flamand L, Gosselin J, D'Addario M, Hiscott J, Ablashi DV, Gallo RC, Menezes J, Journal of virology, 1991, 10.1128/jvi.65.9.5105-5110.1991
Inhibition of tumor necrosis factor-alpha transcription by Epstein-Barr virus., Gosselin J, Menezes J, D'Addario M, Hiscott J, Flamand L, Lamoureux G, Oth D, European journal of immunology, 1991, 10.1002/eji.1830210130
[Role of liposomes in the presentation of HIV envelope glycoprotein and the immune response in mice], Thibodeau L, Chagnon M, Flamand L, Oth D, Lachapelle L, Tremblay C, Montagnier L, Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie, 1989
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Contribution à l'enseignement aux cycles supérieurs
Étudiant(e)s dirigé(e)s*
Depuis 2009
Sabrina Gentil - Maitrîse avec mémoire - En cours
Emile Lacasse - Maitrîse avec mémoire - En cours
Islem Hmida - Doctorat - En cours
Annabelle Mouammine - Post-doctorat - En cours
Shella Gilbert-Girard - Maitrîse avec mémoire - 2016/09
Vanessa Collin - Maitrîse avec mémoire - 2018/09
Encadrement d'étudiant(e)s pour les programmes suivants :
*Les supervisions d’étudiant(e)s de 1er cycle en
stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées
ultérieurement.
Vice-décanat à la recherche et aux études supérieures Pavillon Ferdinand-Vandry Université Laval 1050, avenue de la Médecine, local 4645 Québec, Québec G1V 0A6 Canada
Catherine Comtois Agente de gestion des études etudes.sup2@fmed.ulaval.ca Biostatistique Épidémiologie Évaluation économique des technologies de la santé Santé publique
Marianne Rivest et Claudia Gonzalez Agentes de gestion des études etudes.sup1@fmed.ulaval.ca Biologie cellulaire et moléculaire Génomique fonctionnelle Médecine moléculaire Microbiologie-immunologie Neurosciences
Isabelle Tremblay Agente de gestion des études etudes.sup3@fmed.ulaval.ca Pédagogie universitaire en sciences de la santé Sciences cliniques et biomédicales Sciences de la réadaptation Prévention et gestion de la santé et de la sécurité au travail