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Université Laval
Faculté de médecine

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Louis Flamand

Professeur titulaire

Louis Flamand
louis.flamand@fmed.ulaval.ca
Centre de recherche en infectiologie
Centre de recherche du CHU de Québec - Université Laval
Centre de recherche en arthrite
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Contribution à la recherche

Thématiques de recherche de la Faculté de médecine

  • Immunologie-infectiologie

Projets de recherche en cours

  • National Primate Center for Pandemic Preparedness (NPCPP) - Fondation Canadienne pour l'innovation (La), Ministère de l'Économie et de l'Innovation et de l'énergie, Ministère de l'Enseignement supérieur - Fonds d'infrastructure de recherche en sciences biologiques (FIRSB), co-chercheur - 2024-03-01 au 2028-03-31
  • Human herpesvirus 6 and chromosomal integration - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2023-04-01 au 2028-03-31
  • Dissecting the pathological consequences of neurological infections by herpesviruses, using human iPSC-derived cultures - Instituts de recherche en santé du Canada - Subvention Projet, University of Toronto, co-chercheur - 2021-04-01 au 2026-03-31

Financements des 2 dernières années

  • Pathogenic roles of platelets in sepsis - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2020-03-01 au 2025-03-31
  • Collaboration entre les laboratoires d’Amélie Fradet-Turcotte (AFT) et Louis Flamand (LF) sur l’étude des mécanismes de réponses aux dommages à l’ADN et les infections virales - Université Laval - Fonds internes - BDR - Contributions, chercheur principal - 2023-04-24 au 2024-04-23
  • Coronavirus Variants Rapid Response Network: CoVaRR-Net - Instituts de recherche en santé du Canada - Subvention de fonctionnement:Réseau des IRSC pour la recherche sur les nouveaux variants du COVID-19, Université d'Ottawa, co-chercheur - 2021-03-01 au 2023-03-31
  • Pathogenesis and immune escape potential of SARS-CoV-2 variants of concern - Instituts de recherche en santé du Canada - Subvention de fonctionnement : Possibilité de financement sur les nouveaux besoins prioritaires en recherche sur la COVID-19, chercheur principal - 2021-06-01 au 2022-05-31
  • COVID-19 trilogy: ARDS, inflammation and coagulopathy - Instituts de recherche en santé du Canada - Subvention de fonctionnement : Possibilité de financement pour une intervention de recherche rapide contre la COVID-19, chercheur principal - 2020-06-01 au 2021-05-31

Publications

  • [Role of liposomes in the presentation of HIV envelope glycoprotein and the immune response in mice], Montagnier L, Tremblay C, Lachapelle L, Oth D, Flamand L, Chagnon M, Thibodeau L, Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie, 1989
  • Classification of HHV-6A and HHV-6B as distinct viruses., Yoshikawa T, Luppi M, Jacobson S, Höllsberg P, Gompels UA, Gallo R, Frenkel N, Flamand L, DiLuca D, Dewhurst S, Clark DA, Alvarez-Lafuente R, Agut H, Ablashi D, Archives of virology, 2013, 10.1007/s00705-013-1902-5
  • Infection of peripheral blood mononuclear cells by herpes simplex and Epstein-Barr viruses. Differential induction of interleukin 6 and tumor necrosis factor-alpha., Menezes J, Hiscott J, D'Addario M, Flamand L, Gosselin J, The Journal of clinical investigation, 1992, 10.1172/jci115789
  • Inherited Chromosomally Integrated Human Herpesvirus 6 and Breast Cancer, Louis Flamand, John J. Spinelli, Héctor A. Velásquez-García, Jacques Simard, Kristan J. Aronson, Angela Brooks-Wilson, Isabelle Dubuc, Annie Gravel, Cancer Epidemiology Biomarkers & Prevention, 2016, 10.1158/1055-9965.epi-16-0735
  • Cell culture systems to study Human Herpesvirus 6A/B Chromosomal Integration, Louis Flamand, Benedikt B. Kaufer, Guy Boivin, Julie Carbonneau, Yasuko Mori, Keith R. Jerome, Ruth Hall-Sedlak, Vanessa Collin, Shella Gilbert-Girard, Nina Wallaschek, Isabelle Dubuc, Annie Gravel, Journal of Virology, 2017, 10.1128/jvi.00437-17
  • SARS-CoV-2 deregulates the vascular and immune functions of brain pericytes via Spike protein., , Neurobiology of disease, 2021, 10.1016/j.nbd.2021.105561
  • Human Herpesvirus 6 immediate-early 1 protein is a sumoylated nuclear phosphoprotein colocalizing with promyelocytic leukemia protein-associated nuclear bodies., Flamand L, Gosselin J, Gravel A, The Journal of biological chemistry, 2002, 10.1074/jbc.m200836200
  • Impaired protein kinase C activation/translocation in Epstein-Barr virus-infected monocytes., Gosselin J, Flamand L, Savard M, Tardif M, The Journal of biological chemistry, 2002, 10.1074/jbc.m109036200
  • Multicenter Comparison of PCR Assays for Detection of Human Herpesvirus 6 DNA in Serum, Ablashi D, Yoshikawa T, Tang Y, Kohn D, Malnati M, Jacobson S, Alvarez-Lafuente R, Boutolleau D, Gravel A, Flamand L, Journal of clinical microbiology, 2009
  • Mapping of human herpesvirus 6 immediate-early 2 protein transactivation domains., Flamand L, Gravel A, Tomoiu A, Virology, 2006, 10.1016/j.virol.2006.06.030
  • Antiviral Activity of the G-Quadruplex Ligand TMPyP4 against Herpes Simplex Virus-1, Sara N. Richter, Louis Flamand, Luigi Xodo, Irene Zanin, Annalisa Ferino, Rosalba Perrone, Beatrice Tosoni, Matteo Nadai, Emanuela Ruggiero, Sara Artusi, Viruses, 2021, 10.3390/v13020196
  • The ND10 Complex Represses Lytic Human Herpesvirus 6A Replication and Promotes Silencing of the Viral Genome., Kaufer BB, Wight DJ, Flamand L, Glass M, Wallaschek N, Sanyal A, Viruses, 2018, 10.3390/v10080401
  • Immunosuppressive effect of human herpesvirus 6 on T-cell functions: suppression of interleukin-2 synthesis and cell proliferation., Menezes J, Ablashi D, Stefanescu I, Gosselin J, Flamand L, Blood, 1995
  • Chromatin Profiles of Chromosomally Integrated Human Herpesvirus-6A., Frietze S, Kaufer BB, Flamand L, Dubuc I, Gravel A, Morissette G, Wight DJ, Boyd JR, Gerrard DL, Signorelli SA, Mariani MP, Zimmermann C, Saviola AJ, Frontiers in microbiology, 2019, 10.3389/fmicb.2019.01408
  • Human herpesvirus 6 induces interleukin-1 beta and tumor necrosis factor alpha, but not interleukin-6, in peripheral blood mononuclear cell cultures., Menezes J, Gallo RC, Ablashi DV, Hiscott J, D'Addario M, Gosselin J, Flamand L, Journal of virology, 1991, 10.1128/jvi.65.9.5105-5110.1991
  • Modulation and recruitment of TRF2 at viral telomeres during human herpesvirus 6A/B infection, Flamand L, Lazzerini-Denchi E, Kaufer BB, Wight DJ, Collin V, Gravel A, Gilbert-Girard S, 2019, 10.1101/514075
  • Identification of functional microRNAs released through asymmetrical processing of HIV-1 TAR element., Provost P, Tremblay MJ, Flamand L, Janelle ME, Barat C, Landry P, Plante I, Ouellet DL, Nucleic acids research, 2008, 10.1093/nar/gkn076
  • Human herpesvirus-6 in patients with Crohn's disease., Van Kruiningen HJ, Colombel JF, Cartun R, Ablashi D, Flamand L, Gavrilov B, Sura R, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 2010, 10.1111/j.1600-0463.2010.02613.x
  • The putative U94 integrase is dispensable for human herpesvirus 6 (HHV-6) chromosomal integration, Benedikt B. Kaufer, Louis Flamand, Annie Gravel, Nina Wallaschek, Journal of General Virology, 2016, 10.1099/jgv.0.000502
  • Human herpesvirus 6B immediate-early I protein contains functional HLA-A*02, HLA-A*03, and HLA-B*07 class I restricted CD8(+) T-cell epitopes., Flamand L, O'Reilly RJ, Hasan A, Rousseau M, Dubuc I, Gravel A, Morissette G, Iampietro M, European journal of immunology, 2014, 10.1002/eji.201444931
  • Serological and virological investigation of the role of the herpesviruses EBV, CMV and HHV-6 in post-infective fatigue syndrome., Lloyd A, Ablashi D, Rawlinson W, Naing Z, Middeldorp J, Juwana H, Flamand L, Cameron B, Journal of medical virology, 2010, 10.1002/jmv.21873
  • Chromosomally integrated human herpesvirus 6: questions and answers., Razonable RR, Lassner D, Kuehl U, Kamble RT, Hall CB, Gautheret-Dejean A, Flamand L, Descamps V, Caserta MT, Agut H, Ambros PF, Ablashi DV, Pellett PE, Reviews in medical virology, 2011, 10.1002/rmv.715
  • Summary of the 9th international conference on human herpesviruses 6 and 7 (HHV-6A, HHV-6B, and HHV-7)., Pellett PE, Flamand L, Phan T, Komaroff AL, Journal of medical virology, 2016, 10.1002/jmv.24561
  • Repression of interferon-α stimulated genes expression by Kaposi's sarcoma-associated herpesvirus K-bZIP protein., Flamand L, Gravel A, Lefort S, Virology, 2010, 10.1016/j.virol.2010.07.027
  • Variation in Human Herpesvirus 6B telomeric integration, excision and transmission between tissues and individuals, Royle N, Davison A, Flamand L, Tomaszewski M, Voors A, Samani N, Codd V, Romaine S, Martin D, Parker A, Nichols J, Suárez N, Neumann R, Veal C, Wood M, 2021, 10.1101/2021.06.07.447326
  • Platelets Can Associate with SARS-Cov-2 RNA and Are Hyperactivated in COVID-19., Boilard E, Benouda A, Belefquih B, Belayachi L, Mahir W, Ben El Haj R, Sadki K, Zaid N, Limami Y, Khalki L, Oudghiri M, Naya A, Allaeys I, Puhm F, Zaid Y, Circulation research, 2020, 10.1161/circresaha.120.317703
  • Extra domain A of fibronectin primes leukotriene biosynthesis and stimulates neutrophil migration through activation of Toll-like receptor 4., Borgeat P, Flamand L, Gravel A, Paré G, Picard S, Lévesque T, Lefebvre JS, Arthritis and rheumatism, 2011, 10.1002/art.30308
  • rs73185306 C/T Is Not a Predisposing Risk Factor for Inherited Chromosomally Integrated Human Herpesvirus 6A/B., Flamand L, Dubé MP, Tardif JC, Busseuil D, Provost S, Feroz Zada Y, Dubuc I, Gravel A, Mouammine A, The Journal of infectious diseases, 2020, 10.1093/infdis/jiz527
  • Normal human primary CD4+ T lymphocytes synthesize and release functional osteoprotegerin in vitro., Poubelle PE, Flamand L, Marceau AA, Chakravarti A, Laboratory investigation; a journal of technical methods and pathology, 2007, 10.1038/labinvest.3700701
  • Detection of Human Herpesvirus 6B (HHV-6B) Reactivation in Hematopoietic Cell Transplant Recipients with Inherited Chromosomally Integrated HHV-6A by Droplet Digital PCR., Jerome KR, Boeckh M, Zerr DM, Flamand L, Huang ML, Cook L, Levin G, Cho M, Nguyen T, Hill JA, Sedlak RH, Journal of clinical microbiology, 2016, 10.1128/jcm.03275-15
  • Epstein-Barr virus infects and induces apoptosis in human neutrophils., Gosselin J, Beauchamp D, Gourde P, Flamand L, Larochelle B, Blood, 1998
  • Chemokines and eicosanoids fuel the hyperinflammation within the lungs of patients with severe COVID-19., Flamand L, Boilard É, Flamand N, Laviolette M, Flamand O, Archambault AS, Dubuc I, Doré É, Zaid Y, The Journal of allergy and clinical immunology, 2021, 10.1016/j.jaci.2021.05.032
  • Absence of human herpesvirus 8 DNA sequences in neoplastic Kaposi's sarcoma cell lines., Gallo RC, Lunardi-Iskandar Y, Bryant JL, Zeman RA, Flamand L, Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association, 1996, 10.1097/00042560-199610010-00011
  • Epitope mapping of a monoclonal antibody specific for human herpesvirus 6 variant A immediate-early 2 protein., Flamand L, Tomoiu A, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2007, 10.1016/j.jcv.2006.12.025
  • High levels of eicosanoids and docosanoids in the lungs of intubated COVID-19 patients., Flamand N, Côté A, Tijani Y, El Hassani A, Fares H, Cheikh A, Amar Y, Flamand O, Martin C, Dubuc I, Doré É, Turcotte C, Rakotoarivelo V, Zaid Y, Archambault AS, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021, 10.1096/fj.202100540r
  • Role of PML-Nuclear Bodies in Human Herpesvirus 6A and 6B Genome Integration, Flamand L, Kaufer BB, Gravel A, Collin V, 2018, 10.1101/413575
  • Divergent susceptibilities of human herpesvirus 6 variants to type I interferons., Flamand L, Gravel A, Jaworska J, Proceedings of the National Academy of Sciences of the United States of America, 2010, 10.1073/pnas.0909951107
  • Complete Genome Sequence of Early Passaged Human Herpesvirus 6A (GS Strain) Isolated from North America., Flamand L, Ablashi D, Gravel A, Genome announcements, 2013, 10.1128/genomea.00012-13
  • Characterization of human herpesvirus 6 variant B immediate-early 1 protein modifications by small ubiquitin-related modifiers., Flamand L, Gosselin J, Dion V, Cloutier N, Gravel A, The Journal of general virology, 2004, 10.1099/vir.0.19610-0
  • Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen inhibits interferon (IFN) beta expression by competing with IFN regulatory factor-3 for binding to IFNB promoter., Flamand L, Cloutier N, The Journal of biological chemistry, 2010, 10.1074/jbc.m109.018838
  • Infection of primary human monocytes by Epstein-Barr virus., Gosselin J, Flamand L, Gourde P, Tardif M, Bélanger C, Savard M, Journal of virology, 2000, 10.1128/jvi.74.6.2612-2619.2000
  • Frequency of chromosomally-integrated human herpesvirus 6 in children with acute lymphoblastic leukemia., Flamand L, Sinnett D, Gravel A, PloS one, 2013, 10.1371/journal.pone.0084322
  • Human herpesvirus-6 enhances natural killer cell cytotoxicity via IL-15., Menezes J, Stefanescu I, Flamand L, The Journal of clinical investigation, 1996, 10.1172/jci118557
  • The Promyelocytic Leukemia Protein facilitates human herpesvirus 6B chromosomal integration, immediate-early 1 protein multiSUMOylation and its localization at telomeres., Flamand L, Kaufer BB, Gravel A, Collin V, PLoS pathogens, 2020, 10.1371/journal.ppat.1008683
  • Stabilization of telomere G-quadruplexes interferes with human herpesvirus 6A chromosomal integration, Louis Flamand, Benedikt B. Kaufer, Nina Wallaschek, Sara N. Richter, Sara Artusi, Annie Gravel, Shella Gilbert-Girard, Journal of Virology, 2017, 10.1128/jvi.00402-17
  • Increased Serological Response Against Human Herpesvirus 6A Is Associated With Risk for Multiple Sclerosis., Fogdell-Hahn A, Alonso-Magdalena L, Hortlund M, Jons D, Michel A, Butt J, Brenner N, Khademi M, Stridh P, Lima Bomfim I, Biström M, Huang J, Gustafsson R, Engdahl E, Frontiers in immunology, 2019, 10.3389/fimmu.2019.02715
  • LTB4 increases nasal neutrophil activity and conditions neutrophils to exert antiviral effects., Greiff L, Johnston S, Flamand L, Borgeat P, Andersson M, Widegren H, Respiratory medicine, 2011, 10.1016/j.rmed.2010.12.021
  • Review, part 1: Human herpesvirus-6-basic biology, diagnostic testing, and antiviral efficacy, Dharam V. Ablashi, Peter G. Medveczky, Jesse H. Arbuckle, Anthony L. Komaroff, Louis Flamand, Journal of Medical Virology, 2010, 10.1002/jmv.21839
  • Inhibition of tumor necrosis factor-alpha transcription by Epstein-Barr virus., Oth D, Lamoureux G, Flamand L, Hiscott J, D'Addario M, Menezes J, Gosselin J, European journal of immunology, 1991, 10.1002/eji.1830210130
  • Inhibition of transcription of the beta interferon gene by the human herpesvirus 6 immediate-early 1 protein., Flamand L, Grandvaux N, Fink K, Gravel A, Jaworska J, Journal of virology, 2007, 10.1128/jvi.02443-06
  • Inherited chromosomally integrated HHV-6 demonstrates tissue-specific RNA expressionin vivothat correlates with increased antibody immune response, Greninger AL, Flamand L, Dubé M, Tardif J, Jerome KR, Tenenbaum D, Huang M, Xie H, Gravel A, Dubuc I, Peddu V, 2019, 10.1101/741025
  • Activation of CD8+ T lymphocytes through the T cell receptor turns on CD4 gene expression: implications for HIV pathogenesis., Gallo RC, Margolis DM, Colombini-Hatch S, Lusso P, Crowley RW, Flamand L, Proceedings of the National Academy of Sciences of the United States of America, 1998, 10.1073/pnas.95.6.3111
  • Epstein-Barr virus primes human polymorphonuclear leucocytes for the biosynthesis of leukotriene B4., Borgeat P, Flamand L, Tardif M, Savard M, Gosselin J, Clinical and experimental immunology, 2001, 10.1046/j.1365-2249.2001.01687.x
  • Association between the 2008-09 seasonal influenza vaccine and pandemic H1N1 illness during Spring-Summer 2009: four observational studies from Canada., Canadian SAVOIR Team, Willison DJ, Ouhoummane N, Gilca R, Sethi P, Dickinson JA, Rosella LC, Hottes TS, Boulianne N, Janjua NZ, Crowcroft NS, De Serres G, Skowronski DM, PLoS medicine, 2010, 10.1371/journal.pmed.1000258
  • Influenza virus H1N1 activates platelets through FcγRIIA signaling and thrombin generation., Flamand L, Borgeat P, Lévesque T, Dubuc I, Cloutier N, Rousseau M, Paré G, Boilard E, Blood, 2014, 10.1182/blood-2013-07-515536
  • Kaposi's sarcoma-associated herpesvirus K-bZIP protein is necessary for lytic viral gene expression, DNA replication, and virion production in primary effusion lymphoma cell lines., Flamand L, Lefort S, Journal of virology, 2009, 10.1128/jvi.01821-08
  • Platelet extracellular vesicles in COVID-19: Potential markers and makers., , Journal of leukocyte biology, 2021, 10.1002/jlb.3mir0221-100r
  • HHV-6A/B Integration and the Pathogenesis Associated with the Reactivation of Chromosomally Integrated HHV-6A/B, , Viruses, 2017, 10.3390/v9070160
  • Multiplex detection and quantitation of latent and lytic transcripts of human herpesvirus-8 using RNase Protection Assay., Flamand L, Gravel A, Cloutier N, Journal of virological methods, 2004, 10.1016/j.jviromet.2004.07.004
  • Higher-Order Chromatin Structures of Chromosomally Integrated HHV-6A Predict Integration Sites., Frietze S, Kaufer B, Flamand L, Dest A, Richman A, Gerrard DL, Aimola G, Hasenohr E, Rodriguez P, Zimmerman C, Mariani M, Frontiers in cellular and infection microbiology, 2021, 10.3389/fcimb.2021.612656
  • Pathogenesis from the reactivation of chromosomally integrated human herpesvirus type 6: facts rather than fiction., Flamand L, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2014, 10.1093/cid/ciu326
  • Cyclic AMP-responsive element-dependent activation of Epstein-Barr virus zebra promoter by human herpesvirus 6., Menezes J, Flamand L, Journal of virology, 1996, 10.1128/jvi.70.3.1784-1791.1996
  • Interleukin-15 as an activator of natural killer cell-mediated antiviral response., Flamand L, Gallo RC, TomoIu A, Gosselin J, Blood, 1999
  • Variation in human herpesvirus 6B telomeric integration, excision, and transmission between tissues and individuals., Royle NJ, Davison AJ, Flamand L, Tomaszewski M, Voors AA, Samani NJ, Codd V, Romaine SP, Martin D, Parker AJ, Nichols J, Suárez NM, Neumann R, Veal CD, Wood ML, eLife, 2021, 10.7554/elife.70452
  • Functional interaction between human herpesvirus 6 immediate-early 2 protein and ubiquitin-conjugating enzyme 9 in the absence of sumoylation., Flamand L, Tanguay RM, Gravel A, Tomoiu A, Journal of virology, 2006, 10.1128/jvi.00375-06
  • Characterization of the immediate-early 2 protein of human herpesvirus 6, a promiscuous transcriptional activator., Flamand L, Gosselin J, Cloutier N, Tomoiu A, Gravel A, Virology, 2003, 10.1016/s0042-6822(03)00007-2
  • Herpesviruses and Chromosomal Integration, L. Flamand, G. Morissette, Journal of Virology, 2010, 10.1128/jvi.01169-10
  • Modulatory effects of Epstein-Barr, herpes simplex, and human herpes-6 viral infections and coinfections on cytokine synthesis. A comparative study., Menezes J, Gallo RC, Ablashi DV, Stefanescu I, Hiscott J, D'Addario M, Flamand L, Gosselin J, Journal of immunology (Baltimore, Md. : 1950), 1992
  • Inhibition of interleukin-2 gene expression by human herpesvirus 6B U54 tegument protein., Flamand L, Gravel A, Morissette G, Iampietro M, Journal of virology, 2014, 10.1128/jvi.02030-14
  • Summary of the 11th International Conference on Human Herpesviruses-6A, -6B, and -7., Flamand L, Zerr DM, Komaroff AL, Journal of medical virology, 2019, 10.1002/jmv.25576
  • [Human herpesviruses HHV-6 and chromosomal integration: pathological and medical associated consequences]., Flamand L, Gravel A, Morissette G, Trempe F, Virologie (Montrouge, France), 2011, 10.1684/vir.2011.0428
  • Effects of a urinary factor from women in early pregnancy on HIV-1, SIV and associated disease., Gallo RC, Birken S, Hermans P, Gill P, Flamand L, Hung CL, Blattner WA, Bryant JL, Lunardi-Iskandar Y, Nature medicine, 1998, 10.1038/nm0498-428
  • Release of anti-HIV mediators after administration of leukotriene B4 to humans., Gosselin J, Lalonde R, Borgeat P, Flamand L, The Journal of infectious diseases, 2004, 10.1086/386374
  • The Telomeric Repeats of Human Herpesvirus 6A (HHV-6A) Are Required for Efficient Virus Integration, Benedikt B. Kaufer, Louis Flamand, Yasuko Mori, Annie Gravel, Fabian Pirzer, Anirban Sanyal, Nina Wallaschek, PLOS Pathogens, 2016, 10.1371/journal.ppat.1005666
  • Divergent susceptibilities of human herpesvirus 6 variants to type I interferon, Louis Flamand, Joanna Jaworska, Cytokine, 2009, 10.1016/j.cyto.2009.07.310
  • Multicenter comparison of PCR assays for detection of human herpesvirus 6 DNA in serum., Ablashi D, Yoshikawa T, Tang YW, Kohn D, Malnati MS, Jacobson S, Alvarez-Lafuente R, Boutolleau D, Gravel A, Flamand L, Journal of clinical microbiology, 2008, 10.1128/jcm.00370-08
  • Platelets can contain SARS-CoV-2 RNA and are hyperactivated in COVID-19, Boilard E, Cheikh A, Benouda A, Belefquih B, Lamiae B, Maher W, El Haj RB, Sadki K, Zaid N, Limami Y, Khalki L, Oudghiri M, Naya A, Allaeys I, Puhm F, Zaid Y, 2020, 10.1101/2020.06.23.20137596
  • Role for the shelterin protein TRF2 in human herpesvirus 6A/B chromosomal integration., Flamand L, Lazzerini-Denchi E, Kaufer BB, Wight DJ, Collin V, Gravel A, Gilbert-Girard S, PLoS pathogens, 2020, 10.1371/journal.ppat.1008496
  • The Herpes Simplex Virus-1 genome contains multiple clusters of repeated G-quadruplex: Implications for the antiviral activity of a G-quadruplex ligand., Richter SN, Calistri A, Flamand L, Palù G, Biasolo MA, Perrone R, Nadai M, Artusi S, Antiviral research, 2015, 10.1016/j.antiviral.2015.03.016
  • Leukotriene B4 triggers the in vitro and in vivo release of potent antimicrobial agents., Borgeat P, Tremblay MJ, Flamand L, Journal of immunology (Baltimore, Md. : 1950), 2007, 10.4049/jimmunol.178.12.8036
  • Platelet reactivity to thrombin differs between patients with COVID-19 and those with ARDS unrelated to COVID-19., Flamand L, Boilard E, Jalali F, Cheikh A, Morris AC, Chentoufi L, Elhamdani W, Puhm F, Guessous F, Zaid Y, Blood advances, 2021, 10.1182/bloodadvances.2020003513
  • Amphipathic DNA polymers exhibit antiviral activity against systemic murine Cytomegalovirus infection., Vaillant A, Bernstein DI, Juteau JM, Flamand L, Cummins J, Sewell AP, Bravo FJ, Cardin RD, Virology journal, 2009, 10.1186/1743-422x-6-214
  • The immediate early protein 1 of the human herpesvirus 6B counteracts NBS1 and prevents homologous recombination repair pathways, Fradet-Turcotte A, Flamand L, Gravel A, Dessapt J, Gaudreau-Lavoie É, Tremblay V, Biquand É, Collin V, 2021, 10.1101/2021.07.31.454588
  • Activation of the Epstein-Barr virus replicative cycle by human herpesvirus 6., Menezes J, Ablashi DV, Stefanescu I, Flamand L, Journal of virology, 1993, 10.1128/jvi.67.11.6768-6777.1993
  • Urinary metabolites of leukotriene B4 in the human subject., Murphy RC, Flamand L, Gosselin J, Borgeat P, Berry KA, The Journal of biological chemistry, 2003, 10.1074/jbc.m300856200
  • Increased tumorigenicity of cells carrying recombinant human herpesvirus 8., Flamand L, Gao SJ, Lefort S, Janelle ME, van Eyll O, Cloutier N, Archives of virology, 2007, 10.1007/s00705-007-1072-4
  • Chromosomally integrated HHV-6: impact on virus, cell and organismal biology., Flamand L, Kaufer BB, Current opinion in virology, 2014, 10.1016/j.coviro.2014.09.010
  • Sequence analysis of transplacentally acquired human herpesvirus 6 DNA is consistent with transmission of a chromosomally integrated reactivated virus., Flamand L, Hall CB, Gravel A, The Journal of infectious diseases, 2013, 10.1093/infdis/jit060
  • EBV suppresses prostaglandin E2 biosynthesis in human monocytes., Gosselin J, Borgeat P, Flamand L, Dumais N, Tremblay MJ, Bélanger C, Savard M, Journal of immunology (Baltimore, Md. : 1950), 2000, 10.4049/jimmunol.164.12.6467
  • Mapping the Human Herpesvirus 6B transcriptome., Flamand L, Moorman N, Droit A, Fournier É, Sanders W, Gravel A, Journal of virology, 2021, 10.1128/jvi.01335-20
  • Increased serological response against human herpesvirus 6A is associated with risk for multiple sclerosis, Fogdell-Hahn A, Alonso-Magdalena L, Hortlund M, Jons D, Michel A, Butt J, Brenner N, Khademi M, Stridh P, Bomfim IL, Biström M, Huang J, Gustafsson R, Engdahl E, 2019, 10.1101/737932
  • Contagious period for pandemic (H1N1) 2009., Boivin G, Charest H, Couillard M, Bourgault A, Carbonneau J, Li Y, Boulianne N, Flamand L, Skowronski D, Quach C, Hamelin ME, Rouleau I, De Serres G, Emerging infectious diseases, 2010, 10.3201/eid1605.091894
  • SARS-CoV-2 Nsp2 Contributes to Inflammation by Activating NF-κB, Louis Flamand, Éric Boilard, Isabelle Allaeys, Annie Gravel, Isabelle Dubuc, Leslie Gudimard, Émile Lacasse, Viruses, 2023, 10.3390/v15020334
  • Inhibition of breast cancer cell proliferation through disturbance of the calcineurin/NFAT pathway by human herpesvirus 6B U54 tegument protein., Flamand L, Gravel A, Iampietro M, Journal of virology, 2014, 10.1128/jvi.02107-14
  • Viral Proteins U41 and U70 of Human Herpesvirus 6A Are Dispensable for Telomere Integration., Kaufer BB, Flamand L, Weller SK, Sanyal A, Wallaschek N, Wight DJ, Viruses, 2018, 10.3390/v10110656
  • Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration., Boilard E, Rondina MT, Poirier G, Zhi H, Melki I, Tessandier N, Becker Y, Levesque T, Zufferey A, Mailhot B, Machlus KR, Marcoux G, Allaeys I, Cloutier N, Proceedings of the National Academy of Sciences of the United States of America, 2018, 10.1073/pnas.1720553115
  • Chromosomally Integrated HHV-6, Louis Flamand, Guillaume Morissette, Leonardo Potenza, Mario Luppi, Human Herpesviruses HHV-6A, HHV-6B & HHV-7, 2014, 10.1016/b978-0-444-62703-2.00015-x
  • Activation of monocyte cyclooxygenase-2 gene expression by human herpesvirus 6. Role for cyclic AMP-responsive element-binding protein and activator protein-1., Flamand L, Tremblay MJ, Gosselin J, Gravel A, Janelle ME, The Journal of biological chemistry, 2002, 10.1074/jbc.m203041200
  • Characterization of human herpesvirus 6A/B U94 as ATPase, helicase, exonuclease and DNA-binding proteins, Louis Flamand, Benedikt B. Kaufer, Guillaume Morissette, Shella Gilbert-Girard, Vanessa Collin, Nina Wallaschek, Isabelle Dubuc, Annie Gravel, Frédéric Trempe, Nucleic Acids Research, 2015, 10.1093/nar/gkv503
  • Lipid storm within the lungs of severe COVID-19 patients: Extensive levels of cyclooxygenase and lipoxygenase-derived inflammatory metabolites, Flamand N, Boilard É, Laviolette M, Tijani Y, El Hassani A, Fares H, Cheikh A, Amar Y, Martin C, Dubuc I, Doré É, Rakotoarivelo V, Zaid Y, Archambault A, 2020, 10.1101/2020.12.04.20242115
  • The role of the megakaryocyte in immunity has gone viral., Flamand L, Boilard E, Blood, 2019, 10.1182/blood-2019-02-900787
  • Synergistic activation of interferon-beta gene transcription by the viral FLICE inhibitory protein of Kaposi's sarcoma-associated herpesvirus and type I IFN activators., Flamand L, Grandvaux N, Cloutier N, European journal of immunology, 2007, 10.1002/eji.200737181
  • Phenotypic alterations and survival of monocytes following infection by human herpesvirus-6., Flamand L, Janelle ME, Archives of virology, 2006, 10.1007/s00705-005-0715-6
  • Inherited Chromosomally Integrated Human Herpesvirus 6 Demonstrates Tissue-Specific RNA Expression In Vivo That Correlates with an Increased Antibody Immune Response., Greninger AL, Flamand L, Dubé MP, Tardif JC, Jerome KR, Tenenbaum D, Huang ML, Xie H, Gravel A, Dubuc I, Peddu V, Journal of virology, 2019, 10.1128/jvi.01418-19
  • 2-Arachidonoyl-glycerol- and arachidonic acid-stimulated neutrophils release antimicrobial effectors against E. coli, S. aureus, HSV-1, and RSV., Flamand N, Grandvaux N, Flamand L, Provost V, Bouchard L, Poirier S, Larose MC, Guan X, Turcotte C, Chouinard F, Journal of leukocyte biology, 2012, 10.1189/jlb.0412200
  • Leukotriene B4 protects latently infected mice against murine cytomegalovirus reactivation following allogeneic transplantation., Flamand L, Borgeat P, Gosselin J, Journal of immunology (Baltimore, Md. : 1950), 2005, 10.4049/jimmunol.174.3.1587
  • Human herpesvirus 7 induces the down-regulation of CD4 antigen in lymphoid T cells without affecting p56lck levels., Zauli G, Gallo RC, Capitani S, Marchisio M, Robuffo I, Flamand L, Gibellini D, Secchiero P, Journal of immunology (Baltimore, Md. : 1950), 1997
  • Randomized clinical trial to evaluate the efficacy and safety of valganciclovir in a subset of patients with chronic fatigue syndrome., Desai M, Paik J, Kubo JT, Watt T, Merrihew LE, Flamand L, Lunn MR, Bhangoo M, Kogelnik AM, Montoya JG, Journal of medical virology, 2013, 10.1002/jmv.23713
  • CD4 promoter transactivation by human herpesvirus 6., Gallo RC, Reitz MS, Romerio F, Flamand L, Journal of virology, 1998, 10.1128/jvi.72.11.8797-8805.1998
  • Binding of Kaposi's sarcoma-associated herpesvirus K-bZIP to interferon-responsive factor 3 elements modulates antiviral gene expression., Flamand L, Grandvaux N, Soucy-Faulkner A, Lefort S, Journal of virology, 2007, 10.1128/jvi.00183-07
  • Human herpesvirus 8 viral FLICE-inhibitory protein inhibits Fas-mediated apoptosis through binding and prevention of procaspase-8 maturation., Flamand L, Tremblay MJ, Gosselin J, Janelle ME, Tomoiu A, Gravel A, Bélanger C, Journal of human virology, 2001
  • Inherited chromosomally integrated human herpesvirus 6 as a predisposing risk factor for the development of angina pectoris., Flamand L, Jerome KR, Sedlak RH, Morissette G, Dubuc I, Gravel A, Proceedings of the National Academy of Sciences of the United States of America, 2015, 10.1073/pnas.1502741112
  • Human Herpesvirus 7 induces CD4(+) T-cell death by two distinct mechanisms: necrotic lysis in productively infected cells and apoptosis in uninfected or nonproductively infected cells., Zauli G, Gallo RC, Capitani S, Robuffo I, Falcieri E, Gibellini D, Flamand L, Secchiero P, Blood, 1997
  • Association of human herpes virus 6 (HHV-6) with multiple sclerosis: increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA., Jacobson S, Patnaik M, Lin HC, McFarland HF, Maloni HW, Brennan MB, Calabresi PA, Flamand L, Secchiero P, Salem N, Berti R, Soldan SS, Nature medicine, 1997, 10.1038/nm1297-1394
  • Chromosomal Integration by Human Herpesviruses 6A and 6B., Flamand L, Advances in experimental medicine and biology, 2018, 10.1007/978-981-10-7230-7_10
  • Generation and characterization of a monoclonal antibody specific for human herpesvirus 6 variant A immediate–early 2 protein, Louis Flamand, Jean Gosselin, Annie Gravel, Suzie Arsenault, Journal of Clinical Virology, 2003, 10.1016/s1386-6532(03)00050-7

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2020/07
  • Emile Lacasse - Doctorat - En cours
  • Noémie Rochon - Maîtrise avec mémoire - En cours
  • Ana Claudia Dos Santos Pereira Andrad - Post-doctorat - En cours
  • Joannie Leclerc - Maîtrise avec mémoire - En cours
  • Vanessa Collin - Doctorat - 2021/09
  • Sabrina Gentil - Maîtrise avec mémoire - 2023/09
  • Léa Lambert - Maîtrise avec mémoire - 2024/05

Encadrement d'étudiant(e)s

Direction de recherche dans les domaines suivants :

  • Biologie cellulaire et moléculaire
  • Microbiologie-immunologie

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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Vice-décanat à la recherche et à l'innovation

Pavillon Ferdinand-Vandry
Université Laval
1050, avenue de la Médecine, local 4623
Québec (Québec) G1V 0A6
Canada

Renseignements - Secrétariat
418 656-2690
secretariatvdri@fmed.ulaval.ca

Catherine Mercier
Vice-doyenne à la recherche et à l'innovation