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Jean-Yves Masson

Professeur titulaire

Jean-Yves Masson
jean-yves.masson@fmed.ulaval.ca
Centre de recherche sur le cancer
Centre de recherche du CHU de Québec - Université Laval
Regroupement québécois de recherche sur la fonction, la structure et l'ingénierie des protéines
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Contribution à la recherche

Thématiques de recherche de la Faculté de médecine

  • Oncologie

Projets de recherche en cours

  • Defining the biological consequences of formaldehyde-induced DNA lesions - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2025-04-01 au 2030-03-31
  • Roles of the tumor suppressor PALB2 at the intersection of DNA repair and synthetic lethal strategies in cancer - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2024-10-01 au 2029-09-30
  • Characterization of novel breast cancer susceptibility genes through large-scale targeted sequencing and functional assays. - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2024-04-01 au 2029-03-31
  • Emerging roles of Zinc Finger PAR-Interacting Proteins (ZIPPs) in DNA double-strand break (DSB) repair: implications in PARPi therapy - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2024-04-01 au 2029-03-31
  • Canada Research Chair in DNA repair and Cancer Therapeutics - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2020-07-01 au 2027-06-30
  • Caractérisation de nouveaux gènes de susceptibilité au cancer du sein - Ministère de l'Économie et de l'Innovation et de l'énergie - Programme de soutien aux organismes de recherche et d’innovation (PSO) - International Volet 2C(Ancien PSR-SIIRI), co-chercheur - 2024-02-15 au 2027-04-01
  • Unveiling the roles of Poly(ADP)ribose Glycohydrolase (PARG) in DNA repair and cancer - Société de recherche sur le cancer - Subvention de fonctionnement, chercheur principal - 2024-09-01 au 2026-08-31
  • Assays evaluating small molecule RAD51 inhibitors: the road to anti-RAD51 drugs to treat aggressive and drug-resistant breast cancer - Breast Cancer Canada - Research Grant Competition, University of Western Ontario, co-chercheur - 2024-06-30 au 2026-06-29
  • Réseau de recherche sur le cancer (RRCancer) - Fonds de recherche du Québec - Santé - ONCOPOLE EMC2: Équipes multi-institutionnelles contre le cancer, chercheur principal - 2023-04-01 au 2026-03-31
  • Decoding the DNA double-strand break repair pathways: from mechanistic insights to human genome instability diseases - Instituts de recherche en santé du Canada - Subventions Fondation, chercheur principal - 2018-07-01 au 2025-06-30

Financements des 2 dernières années

  • Poly(ADP-ribose) writers, readers, and erasers: Functions in DNA double-strand break repair and synthetic lethality - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2019-10-01 au 2024-09-30
  • Fonds de cancérologie et ses fonds liés - Fondation de l'Université Laval - 2005-04-01 au 2024-04-30
  • Tumor biobanking was supported by the Banque de tissus et de données en cancers solides of the Réseau de recherche sur le cancer (RRCancer)...The RRCancer is funded by the Oncopole...de l'Économie, de l'Innovation et de l'Énergie du Québec. - Fonds de recherche du Québec - Santé - ONCOPOLE EMC2: Équipes multi-institutionnelles contre le cancer, chercheur principal - 2023-04-01 au 2024-03-31
  • Investigating the Role of RECQL in Breast Cancer Susceptibility - Instituts de recherche en santé du Canada - Subvention Projet, University of Toronto, co-chercheur - 2017-04-01 au 2022-03-31
  • Personalized Risk Assesment for Prevention and Early Detection of Breast Cancer : Integration and Implementation (PERSPECTIVE II) - Regroupement de compagnies et corporations canadiennes, Fondation du CHU de Québec, Génome Québec, Ministère de la santé (Ontario), Ministère de l'Économie, de la Science et de l'Innovation, Instituts de recherche en santé du Canada, Fondation du cancer du sein du Québec, Génome Canada - Projets de recherche appliquée à grande échelle - Large-Scale Applied Research Project, co-chercheur - 2017-11-01 au 2022-03-31

Publications

  • Targeting Allostery with Avatars to Design Inhibitors Assessed by Cell Activity: Dissecting MRE11 Endo- and Exonuclease Activities., , Methods in enzymology, 2018, 10.1016/bs.mie.2017.11.030
  • PRMT7 methylates eukaryotic translation initiation factor 2α and regulates its role in stress granule formation., , Molecular biology of the cell, 2019, 10.1091/mbc.e18-05-0330
  • XAB2 promotes Ku eviction from single-ended DNA double-strand breaks independently of the ATM kinase., , Nucleic acids research, 2021, 10.1093/nar/gkab785
  • Recovery of deficient homologous recombination in Brca2-depleted mouse cells by wild-type Rad51 expression., , DNA repair, 2008, 10.1016/j.dnarep.2008.10.002
  • The RNF138 E3 ligase displaces Ku to promote DNA end resection and regulate DNA repair pathway choice., , Nature cell biology, 2015, 10.1038/ncb3259
  • The Hop2 and Mnd1 proteins act in concert with Rad51 and Dmc1 in meiotic recombination., , Nature structural & molecular biology, 2005, 10.1038/nsmb923
  • DDX5 resolves R-loops at DNA double-strand breaks to promote DNA repair and avoid chromosomal deletions., , NAR cancer, 2020, 10.1093/narcan/zcaa028
  • DNA repair pathways in trypanosomatids: from DNA repair to drug resistance., , Microbiology and molecular biology reviews : MMBR, 2014, 10.1128/mmbr.00045-13
  • Role of BRCA2 in control of the RAD51 recombination and DNA repair protein., , Molecular cell, 2001, 10.1016/s1097-2765(01)00175-7
  • A Saccharomyces cerevisiae mutant defines a new locus essential for resistance to the antitumour drug bleomycin., , Canadian journal of microbiology, 1996, 10.1139/m96-105
  • Replication Protein A Availability during DNA Replication Stress Is a Major Determinant of Cisplatin Resistance in Ovarian Cancer Cells., , Cancer research, 2018, 10.1158/0008-5472.can-18-0618
  • The Rad51 and Dmc1 recombinases: a non-identical twin relationship., , Trends in biochemical sciences, 2001, 10.1016/s0968-0004(00)01742-4
  • Characterization of amino acid substitutions that severely alter the DNA repair functions of Escherichia coli endonuclease IV., , Biochemistry, 1999, 10.1021/bi9824083
  • FAN1 exo- not endo-nuclease pausing on disease-associated slipped-DNA repeats: A mechanism of repeat instability., , Cell reports, 2021, 10.1016/j.celrep.2021.110078
  • Cancer-causing mutations in the tumor suppressor PALB2 reveal a novel cancer mechanism using a hidden nuclear export signal in the WD40 repeat motif., , Nucleic acids research, 2017, 10.1093/nar/gkx011
  • A key role for poly(ADP-ribose) polymerase 3 in ectodermal specification and neural crest development., , PloS one, 2011, 10.1371/journal.pone.0015834
  • BRN2 suppresses apoptosis, reprograms DNA damage repair, and is associated with a high somatic mutation burden in melanoma., , Genes & development, 2019, 10.1101/gad.314633.118
  • Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways., , Human molecular genetics, 2004, 10.1093/hmg/ddh135
  • The transcriptional activator Imp2p maintains ion homeostasis in Saccharomyces cerevisiae., , Genetics, 1998, 10.1093/genetics/149.2.893
  • DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of Cancer., , Biomolecules, 2015, 10.3390/biom5043204
  • Arginine methylation of hnRNPUL1 regulates interaction with NBS1 and recruitment to sites of DNA damage., , Scientific reports, 2015, 10.1038/srep10475
  • MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription-replication conflicts., , Nature communications, 2019, 10.1038/s41467-019-12271-w
  • Arginine methylation of the DDX5 helicase RGG/RG motif by PRMT5 regulates resolution of RNA:DNA hybrids., , The EMBO journal, 2019, 10.15252/embj.2018100986
  • A requirement for polymerized actin in DNA double-strand break repair., , Nucleus (Austin, Tex.), 2012, 10.4161/nucl.21055
  • The microRNA pathway controls germ cell proliferation and differentiation in C. elegans., , Cell research, 2012, 10.1038/cr.2012.31
  • DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells., , Nature, 2018, 10.1038/s41586-018-0670-5
  • Limiting the DNA Double-Strand Break Resectosome for Genome Protection., , Trends in biochemical sciences, 2020, 10.1016/j.tibs.2020.05.003
  • Partners apart: Smc6-independent DNA binding activity of Smc5 on single-strand DNA., , Cell cycle (Georgetown, Tex.), 2011, 10.4161/cc.10.7.15212
  • Reconstitution of the strand invasion step of double-strand break repair using human Rad51 Rad52 and RPA proteins., , Journal of molecular biology, 2000, 10.1006/jmbi.2000.4180
  • Normal processing of AP sites in Apn1-deficient Saccharomyces cerevisiae is restored by Escherichia coli genes expressing either exonuclease III or endonuclease III., , Molecular microbiology, 1997, 10.1046/j.1365-2958.1997.3841748.x
  • HELB Is a Feedback Inhibitor of DNA End Resection., , Molecular cell, 2016, 10.1016/j.molcel.2015.12.013
  • Development of a 3D functional assay and identification of biomarkers, predictive for response of high-grade serous ovarian cancer (HGSOC) patients to poly-ADP ribose polymerase inhibitors (PARPis): targeted therapy., , Journal of translational medicine, 2020, 10.1186/s12967-020-02613-4
  • Functional mitochondria are essential for Saccharomyces cerevisiae cellular resistance to bleomycin., , Current genetics, 1996, 10.1007/s002940050133
  • Missense PALB2 germline variant disrupts nuclear localization of PALB2 in a patient with breast cancer., , Familial cancer, 2020, 10.1007/s10689-020-00163-8
  • Genome-wide R-loop analysis defines unique roles for DDX5, XRN2, and PRMT5 in DNA/RNA hybrid resolution., , Life science alliance, 2020, 10.26508/lsa.202000762
  • Roles of Rad51 paralogs for promoting homologous recombination in Leishmania infantum., , Nucleic acids research, 2015, 10.1093/nar/gkv118
  • RECQ-like helicases Sgs1 and BLM regulate R-loop-associated genome instability., , The Journal of cell biology, 2017, 10.1083/jcb.201703168
  • Identification and purification of two distinct complexes containing the five RAD51 paralogs., , Genes & development, 2001, 10.1101/gad.947001
  • The meiosis-specific recombinase hDmc1 forms ring structures and interacts with hRad51., , The EMBO journal, 1999, 10.1093/emboj/18.22.6552
  • The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation., , Cell research, 2011, 10.1038/cr.2011.128
  • The identification of FANCD2 DNA binding domains reveals nuclear localization sequences., , Nucleic acids research, 2017, 10.1093/nar/gkx543
  • SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice., , The EMBO journal, 2018, 10.15252/embj.2018100158
  • ABRAXAS (FAM175A) and Breast Cancer Susceptibility: No Evidence of Association in the Breast Cancer Family Registry., , PloS one, 2016, 10.1371/journal.pone.0156820
  • Chromosomal Translocations in the Parasite Leishmania by a MRE11/RAD50-Independent Microhomology-Mediated End Joining Mechanism., , PLoS genetics, 2016, 10.1371/journal.pgen.1006117
  • MRE11-RAD50-NBS1 Complex Is Sufficient to Promote Transcription by RNA Polymerase II at Double-Strand Breaks by Melting DNA Ends., , Cell reports, 2021, 10.1016/j.celrep.2020.108565
  • Roles for APRIN (PDS5B) in homologous recombination and in ovarian cancer prediction., , Nucleic acids research, 2016, 10.1093/nar/gkw921
  • RAD51C is required for Holliday junction processing in mammalian cells., , Science (New York, N.Y.), 2004, 10.1126/science.1093037
  • Functional and structural basis for a bacteriophage homolog of human RAD52., , Current biology : CB, 2008, 10.1016/j.cub.2008.06.071
  • FANCD2: A DNA binding protein regulated by MRE11-RAD50-NBS1., , Cell cycle (Georgetown, Tex.), 2010, 10.4161/cc.9.2.10492
  • GST-His purification: a two-step affinity purification protocol yielding full-length purified proteins., , Journal of visualized experiments : JoVE, 2013, 10.3791/50320
  • Interactions between BRCA2 and RAD51 for promoting homologous recombination in Leishmania infantum., , Nucleic acids research, 2012, 10.1093/nar/gks306
  • [Functions of PALB2 and BRCA2 tumor suppressors in DNA double-strand break repair]., , Medecine sciences : M/S, 2013, 10.1051/medsci/2013293017
  • Zinc finger protein E4F1 cooperates with PARP-1 and BRG1 to promote DNA double-strand break repair., , Proceedings of the National Academy of Sciences of the United States of America, 2021, 10.1073/pnas.2019408118
  • Human Dmc1 protein binds DNA as an octameric ring., , Proceedings of the National Academy of Sciences of the United States of America, 1999, 10.1073/pnas.96.19.10684
  • PARP activation regulates the RNA-binding protein NONO in the DNA damage response to DNA double-strand breaks., , Nucleic acids research, 2012, 10.1093/nar/gks798
  • Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair., , Proceedings of the National Academy of Sciences of the United States of America, 2013, 10.1073/pnas.1309085110
  • Investigation of the DNA damage response to SFOM-0046, a new small-molecule drug inducing DNA double-strand breaks., , Scientific reports, 2016, 10.1038/srep23302
  • RAD51 protects against nonconservative DNA double-strand break repair through a nonenzymatic function., , Nucleic acids research, 2022, 10.1093/nar/gkac073
  • Synthesis and biological evaluation of novel N-phenyl ureidobenzenesulfonate derivatives as potential anticancer agents. Part 2. Modulation of the ring B., , European journal of medicinal chemistry, 2015, 10.1016/j.ejmech.2015.09.012
  • CRISPR/Cas9 Gene Editing: From Basic Mechanisms to Improved Strategies for Enhanced Genome Engineering In Vivo., , Current gene therapy, 2017, 10.2174/1566523217666171122094629
  • Primary sequence of the chitosanase from Streptomyces sp. strain N174 and comparison with other endoglycosidases., , Gene, 1994, 10.1016/0378-1119(94)90738-2
  • Methylation of MRE11 regulates its nuclear compartmentalization., , Cell cycle (Georgetown, Tex.), 2005, 10.4161/cc.4.7.1830
  • Detection of the HIV-1 minus-strand-encoded antisense protein and its association with autophagy., , Journal of virology, 2013, 10.1128/jvi.00225-13
  • A PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylation., , eLife, 2017, 10.7554/elife.20922
  • Double-strand break repair in human cells., , Cold Spring Harbor symposia on quantitative biology, 2000, 10.1101/sqb.2000.65.315
  • Personalized Risk Assessment for Prevention and Early Detection of Breast Cancer: Integration and Implementation (PERSPECTIVE I&I)., , Journal of personalized medicine, 2021, 10.3390/jpm11060511
  • SAM68 interaction with U1A modulates U1 snRNP recruitment and regulates mTor pre-mRNA splicing., , Nucleic acids research, 2019, 10.1093/nar/gkz099
  • ZNF768 links oncogenic RAS to cellular senescence., , Nature communications, 2021, 10.1038/s41467-021-24932-w
  • Multiple regulatory elements control the basal promoter activity of the human alpha 4 integrin gene., , DNA and cell biology, 1994, 10.1089/dna.1994.13.1071
  • Role of mammalian RAD51L2 (RAD51C) in recombination and genetic stability., , The Journal of biological chemistry, 2002, 10.1074/jbc.m201402200
  • Novel RNA and DNA strand exchange activity of the PALB2 DNA binding domain and its critical role for DNA repair in cells., , eLife, 2019, 10.7554/elife.44063
  • Special AT-rich Sequence-binding Protein 1 (SATB1) Functions as an Accessory Factor in Base Excision Repair., , The Journal of biological chemistry, 2016, 10.1074/jbc.m116.735696
  • The Werner syndrome protein affects the expression of genes involved in adipogenesis and inflammation in addition to cell cycle and DNA damage responses., , Cell cycle (Georgetown, Tex.), 2009, 10.4161/cc.8.13.8925
  • Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging., , Journal of visualized experiments : JoVE, 2021, 10.3791/62553
  • A slipped-CAG DNA-binding small molecule induces trinucleotide-repeat contractions in vivo., , Nature genetics, 2020, 10.1038/s41588-019-0575-8
  • FAN1, a DNA Repair Nuclease, as a Modifier of Repeat Expansion Disorders., , Journal of Huntington's disease, 2021, 10.3233/jhd-200448
  • Functions of the CSB Protein at Topoisomerase 2 Inhibitors-Induced DNA Lesions., , Frontiers in cell and developmental biology, 2021, 10.3389/fcell.2021.727836
  • Effect of regulatory sequence substitution on chitosanase production from a cloned gene in Streptomyces lividans, , In: Chitin World. Ed. Z. Karnicki, M.M. Brzezki, J. Dutkiewicz & A. Wojtasz-Pajak, Editors, Elsevier Applied Science, Amsterdam., 1995
  • E4F1 is a master regulator of CHK1-mediated functions., , Cell reports, 2015, 10.1016/j.celrep.2015.03.019
  • Functional analysis of genetic variants in the high-risk breast cancer susceptibility gene PALB2., , Nature communications, 2019, 10.1038/s41467-019-13194-2
  • A new chitosanase gene from a Nocardioides sp. is a third member of glycosyl hydrolase family 46., , Microbiology (Reading, England), 1995, 10.1099/13500872-141-10-2629
  • [A new role for arginine methylation in DNA repair]., , Medecine sciences : M/S, 2005, 10.1051/medsci/2005216-7579
  • Structure and function of phage p2 ORF34(p2), a new type of single-stranded DNA binding protein., , Molecular microbiology, 2009, 10.1111/j.1365-2958.2009.06844.x
  • A RAD51 assay feasible in routine tumor samples calls PARP inhibitor response beyond BRCA mutation., , EMBO molecular medicine, 2018, 10.15252/emmm.201809172
  • PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites., , The Journal of biological chemistry, 2007, 10.1074/jbc.m706734200
  • CSB interacts with BRCA1 in late S/G2 to promote MRN- and CtIP-mediated DNA end resection., , Nucleic acids research, 2019, 10.1093/nar/gkz784
  • Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1., , Nature communications, 2018, 10.1038/s41467-018-06854-2
  • Conformational changes modulate the activity of human RAD51 protein., , Journal of molecular biology, 2004, 10.1016/j.jmb.2004.02.022
  • Irinotecan and DNA-PKcs inhibitors synergize in killing of colon cancer cells., , Investigational new drugs, 2011, 10.1007/s10637-010-9626-9
  • Perturbing cohesin dynamics drives MRE11 nuclease-dependent replication fork slowing., , Nucleic acids research, 2019, 10.1093/nar/gky519
  • Saccharomyces cerevisiae DNA repair processes: an update., , Molecular and cellular biochemistry, 1996, 10.1007/bf00225884
  • Cockayne syndrome group B protein regulates fork restart, fork progression and MRE11-dependent fork degradation in BRCA1/2-deficient cells., , Nucleic acids research, 2021, 10.1093/nar/gkab1173
  • Variants of uncertain clinical significance in hereditary breast and ovarian cancer genes: best practices in functional analysis for clinical annotation., , Journal of medical genetics, 2020, 10.1136/jmedgenet-2019-106368
  • Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks., , Nature communications, 2019, 10.1038/s41467-019-10741-9
  • Proteome-wide identification of WRN-interacting proteins in untreated and nuclease-treated samples., , Journal of proteome research, 2011, 10.1021/pr100990s
  • Coupling of Homologous Recombination and the Checkpoint by ATR., , Molecular cell, 2017, 10.1016/j.molcel.2016.12.007
  • Lactococcal phage p2 ORF35-Sak3 is an ATPase involved in DNA recombination and AbiK mechanism., , Molecular microbiology, 2011, 10.1111/j.1365-2958.2011.07561.x
  • XRCC3 and Rad51 modulate replication fork progression on damaged vertebrate chromosomes., , Molecular cell, 2003, 10.1016/s1097-2765(03)00132-1
  • Animal models of Fanconi anemia: A developmental and therapeutic perspective on a multifaceted disease., , Seminars in cell & developmental biology, 2021, 10.1016/j.semcdb.2020.11.010
  • Synthesis, biological evaluation, and structure-activity relationships of novel substituted N-phenyl ureidobenzenesulfonate derivatives blocking cell cycle progression in S-phase and inducing DNA double-strand breaks., , Journal of medicinal chemistry, 2012, 10.1021/jm3006492
  • Emerging roles of eraser enzymes in the dynamic control of protein ADP-ribosylation., , Nature communications, 2019, 10.1038/s41467-019-08859-x
  • A functionally impaired missense variant identified in French Canadian families implicates FANCI as a candidate ovarian cancer-predisposing gene., , Genome medicine, 2021, 10.1186/s13073-021-00998-5
  • The Caenorhabditis elegans gene CeAPN1 encodes a homolog of Escherichia coli and yeast apurinic/apyrimidinic endonuclease., , Gene, 1996, 10.1016/s0378-1119(96)00375-7
  • Fission yeast rad51 and dmc1, two efficient DNA recombinases forming helical nucleoprotein filaments., , Molecular and cellular biology, 2005, 10.1128/mcb.25.11.4377-4387.2005
  • The Saccharomyces cerevisiae IMP2 gene encodes a transcriptional activator that mediates protection against DNA damage caused by bleomycin and other oxidants., , Molecular and cellular biology, 1996, 10.1128/mcb.16.5.2091
  • CBX4-mediated SUMO modification regulates BMI1 recruitment at sites of DNA damage., , Nucleic acids research, 2012, 10.1093/nar/gks222
  • Interactions of the Rad51 inhibitor DIDS with human and bovine serum albumins: Optical spectroscopy and isothermal calorimetry approaches., , Biochimie, 2019, 10.1016/j.biochi.2019.09.016
  • Exploring the multiple facets of the meiotic recombinase Dmc1., , BioEssays : news and reviews in molecular, cellular and developmental biology, 2004, 10.1002/bies.20150
  • Stimulation of fission yeast and mouse Hop2-Mnd1 of the Dmc1 and Rad51 recombinases., , Nucleic acids research, 2007, 10.1093/nar/gkm174
  • Factors governing efficient chitosanase production by recombinant Streptomyces lividans strains carrying the cloned chs gene from Streptomyces N174., , In: Chitin Enzymology. Ed. R.A.A. Muzzarelli. European Chitin Society, Ancona, 1993
  • A yeast homologue of the human phosphotyrosyl phosphatase activator PTPA is implicated in protection against oxidative DNA damage induced by the model carcinogen 4-nitroquinoline 1-oxide., , The Journal of biological chemistry, 1998, 10.1074/jbc.273.34.21489
  • PALB2 Variants: Protein Domains and Cancer Susceptibility., , Trends in cancer, 2020, 10.1016/j.trecan.2020.10.002
  • Twists and turns in the function of DNA damage signaling and repair proteins by post-translational modifications., , DNA repair, 2007, 10.1016/j.dnarep.2006.12.009
  • Starvation-induced proteasome assemblies in the nucleus link amino acid supply to apoptosis., , Nature communications, 2021, 10.1038/s41467-021-27306-4
  • A Saccharomyces cerevisiae phleomycin-sensitive mutant, ph140, is defective in the RAD6 DNA repair gene., , Canadian journal of microbiology, 1996, 10.1139/m96-164
  • Chromatin remodeling and the maintenance of genome integrity., , Biochimica et biophysica acta, 2004, 10.1016/j.bbaexp.2003.10.016
  • Functional characterization of 84 PALB2 variants of uncertain significance., , Genetics in medicine : official journal of the American College of Medical Genetics, 2019, 10.1038/s41436-019-0682-z
  • Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control., , Genes & development, 2005, 10.1101/gad.1279805
  • A global functional analysis of missense mutations reveals two major hotspots in the PALB2 tumor suppressor., , Nucleic acids research, 2019, 10.1093/nar/gkz780
  • Schizosaccharomyces pombe apn1 encodes a homologue of the Escherichia coli endonuclease IV family of DNA repair proteins., , Biochimica et biophysica acta, 1998, 10.1016/s0167-4781(97)00160-7
  • Molecular Determinant of DIDS Analogs Targeting RAD51 Activity., , Molecules (Basel, Switzerland), 2021, 10.3390/molecules26185460
  • Complex formation by the human RAD51C and XRCC3 recombination repair proteins., , Proceedings of the National Academy of Sciences of the United States of America, 2001, 10.1073/pnas.111005698
  • Reprogramming cellular events by poly(ADP-ribose)-binding proteins., , Molecular aspects of medicine, 2012, 10.1016/j.mam.2012.12.005
  • The effect of a DNA repair gene on cellular invasiveness: XRCC3 over-expression in breast cancer cells., , PloS one, 2011, 10.1371/journal.pone.0016394
  • The transcriptional histone acetyltransferase cofactor TRRAP associates with the MRN repair complex and plays a role in DNA double-strand break repair., , Molecular and cellular biology, 2006, 10.1128/mcb.26.2.402-412.2006
  • MRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repair., , The EMBO journal, 2009, 10.1038/emboj.2009.193
  • The Schizosaccharomyces pombe spqM gene is a new member of the Qm transcription factor family., , Gene, 1996, 10.1016/0378-1119(95)00853-5
  • The Tumor Suppressor PALB2: Inside Out., , Trends in biochemical sciences, 2019, 10.1016/j.tibs.2018.10.008
  • Phospho-dependent recruitment of the yeast NuA4 acetyltransferase complex by MRX at DNA breaks regulates RPA dynamics during resection., , Proceedings of the National Academy of Sciences of the United States of America, 2018, 10.1073/pnas.1806513115
  • SUMOylation mediates CtIP's functions in DNA end resection and replication fork protection., , Nucleic acids research, 2021, 10.1093/nar/gkaa1232
  • A Fanci knockout mouse model reveals common and distinct functions for FANCI and FANCD2., , Nucleic acids research, 2019, 10.1093/nar/gkz514
  • Formation of linear amplicons with inverted duplications in Leishmania requires the MRE11 nuclease., , PLoS genetics, 2014, 10.1371/journal.pgen.1004805
  • ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repair., , EMBO reports, 2012, 10.1038/embor.2011.243
  • Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination., , Nature structural & molecular biology, 2010, 10.1038/nsmb.1915
  • Exploring the roles of PALB2 at the crossroads of DNA repair and cancer., , The Biochemical journal, 2014, 10.1042/bj20140208
  • Mammalian protein arginine methyltransferase 7 (PRMT7) specifically targets RXR sites in lysine- and arginine-rich regions., , The Journal of biological chemistry, 2013, 10.1074/jbc.m113.525345
  • Interplay between human DNA repair proteins at a unique double-strand break in vivo., , The EMBO journal, 2006, 10.1038/sj.emboj.7600914
  • Fanconi anemia group J helicase and MRE11 nuclease interact to facilitate the DNA damage response., , Molecular and cellular biology, 2013, 10.1128/mcb.01256-12
  • Breast cancer proteins PALB2 and BRCA2 stimulate polymerase η in recombination-associated DNA synthesis at blocked replication forks., , Cell reports, 2014, 10.1016/j.celrep.2014.01.009
  • Deciphering the function of lactococcal phage ul36 Sak domains., , Journal of structural biology, 2009, 10.1016/j.jsb.2009.12.021
  • A DNA repair-independent role for alkyladenine DNA glycosylase in alkylation-induced unfolded protein response., , Proceedings of the National Academy of Sciences of the United States of America, 2022, 10.1073/pnas.2111404119
  • The Canadian Rare Diseases Models and Mechanisms (RDMM) Network: Connecting Understudied Genes to Model Organisms., , American journal of human genetics, 2020, 10.1016/j.ajhg.2020.01.009
  • Synergistic effects of type I PRMT and PARP inhibitors against non-small cell lung cancer cells., , Clinical epigenetics, 2021, 10.1186/s13148-021-01037-1
  • Lysine methylation of FEN1 by SET7 is essential for its cellular response to replicative stress., , Oncotarget, 2017, 10.18632/oncotarget.18070
  • A glycine-arginine domain in control of the human MRE11 DNA repair protein., , Molecular and cellular biology, 2008, 10.1128/mcb.02025-07
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Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2020/05
  • Sadaf Valeh Sheida - Doctorat - En cours
  • Louis Marie Paul Michel Nonfoux - Doctorat - En cours
  • Sofiane Yacine Mersaoui - Post-doctorat - En cours
  • Mélissa Thomas - Post-doctorat - En cours
  • Laure Guitton - Post-doctorat - En cours
  • Larissa Milano de Souza - Post-doctorat - En cours
  • Sara Berrada - Post-doctorat - En cours
  • Nurgul Atalay - Doctorat - En cours
  • Yuandi Gao - Maîtrise avec mémoire - 2020/09
  • Julia O'Sullivan - Doctorat - 2021/09
  • Thibaut Peterlini - Doctorat - 2022/05
  • Daryl Hyacinth Acuna Ronato - Doctorat - 2023/05
  • Adèle Beneyton - Doctorat - 2025/01

Encadrement d'étudiant(e)s

Direction de recherche dans les domaines suivants :

  • Biologie cellulaire et moléculaire
  • Médecine moléculaire

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Disponibilité d'encadrement d'étudiant(e)s

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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