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Université Laval
Faculté de médecine

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Jacques J. Tremblay

Professeur titulaire

Jacques J. Tremblay
jacques-j.tremblay@fmed.ulaval.ca
Centre de recherche en reproduction, développement et santé intergénérationnelle
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Thématiques de recherche de la Faculté de médecine

  • Reproduction, génétique, périnatalité et développement

Domaines de recherche

  • Physiologie animale, endocrinologie
    • [Testostérone][Androgènes][Cellules de Leydig][Différenciation sexuelle masculine][Différences du développement sexuel][Hypogonadisme primaire][Action hormonale]
  • Régulation et expression des gènes
    • [Facteurs de transcription][Transcription]
  • Transcriptomique
  • Protéomique
  • Transgenèse
  • Médecine régénérative (y compris les cellules souches et le génie tissulaire)
    • [Cellules souches de Leydig]
  • Prolifération, différenciation et mort cellulaires
  • Biologie du développement et de la reproduction des animaux
  • Signalisation intracellulaire, transduction des signaux, biologie des récepteurs et des membranes
    • [Signalisation en aval du récepteur LH]

Projets de recherche en cours

  • Réseau Québécois en Reproduction - Fonds de recherche du Québec - Nature et technologies - Regroupements stratégiques NT, Université de Montréal, co-chercheur - 2024-04-01 au 2030-03-31
  • Defining the role of GATA4 in steroidogenic cells and sex differentiation in males using novel mouse models - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2023-04-01 au 2028-03-31
  • Probing the origins and crosstalk between the different Leydig cell populations in the mammalian gonad - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2022-04-01 au 2027-03-31
  • Upgrade of a the CHUQ-UL Axe of reproduction microscopy platfrom - Conseil de recherches en sciences naturelles et génie Canada - Subventions d'outils et d'instruments de recherche (OIR), co-chercheur - 2025-03-31 au 2026-03-31

Financements des 2 dernières années

  • Réseau Québécois en Reproduction (RQR) - Fonds de recherche du Québec - Nature et technologies, Université de Sherbrooke, Université Laval - Fonds internes, Université de Montréal, Université du Québec à Trois-Rivières, Institut national de recherche scientifique (INRS) - Regroupements stratégiques NT, Université de Montréal, co-chercheur - 2017-04-01 au 2023-03-31

Publications

  • FOXA3 Is Expressed in Multiple Cell Lineages in the Mouse Testis and Regulates Pdgfra Expression in Leydig Cells, Tremblay, Jacques J., Robert, Nicholas M., Brousseau, Catherine, Bergeron, Francis, Garon, Gabriel, Endocrinology, 2017, 10.1210/EN.2016-1736
  • Human and murine PTX1/Ptx1 gene maps to the region for Treacher Collins Syndrome, Drouin, J, Beatty, B, Copeland, N, Gilbert, D, Jenkins, N, Tremblay, JJ, Lanctot, C, Crawford, MJ, Mammalian Genome, 1997, 10.1007/S003359900589
  • Ptx1, a bicoid-related homeo box transcription factor involved in transcription of the pro-opiomelanocortin gene, Drouin, J, Gauthier, Y, Therrien, M, Lanctot, C, Tremblay, JJ, Lamonerie, T, Genes & Development, 1996, 10.1101/GAD.10.10.1284
  • Transcriptional properties of Pitx1 and its role in hindlimb specification, Tremblay, JJ, Poulin, G, Marcil, A, Moreau, A, Drouin, J, Lanctot, C, Developmental Dynamics, 2000
  • Novel Targets for the Transcription Factors MEF2 in MA-10 Leydig Cells, Tremblay, Jacques J., Bergeron, Francis, Daems, Caroline, Di-Luoffo, Mickael, Biology of Reproduction, 2015, 10.1095/BIOLREPROD.114.127761
  • Identification of MEF2A, MEF2C, and MEF2D interactomes in basal and Fsk‐stimulated mouse MA‐10 Leydig cells, Jacques J. Tremblay, Robert S. Viger, Arnaud Droit, Marie‐Pier Scott‐Boyer, Karine de Mattos, Andrology, 2025, 10.1111/andr.70051
  • The orphan nuclear receptor Nur77 is a novel regulator of cAMP-mediated StAR gene expression, Tremblay, JJ, Martin, LJ, Biology of Reproduction, 2004
  • Role of nuclear receptors in INSL3 gene transcription in Leydig cells., Robert NM, Tremblay JJ, Annals of the New York Academy of Sciences, 2005, 10.1196/annals.1336.020
  • THE NUCLEAR RECEPTOR COUP-TFII ACTIVATES STAR GENE TRANSCRIPTION IN COOPERATION WITH CAMKI IN LEYDIG CELLS, Tremblay, Jacques J., Brousseau, Catherine, Martin, Luc J., Mendoza, Raifish, Journal of Andrology, 2011
  • The Ptx family of homeodomain transcription factors, Tremblay, JJ, Lanctot, C, Drouin, J, Medecine Sciences: M/S, 1998, 10.4267/10608/1040
  • The Urokinase-Type Plasminogen Activator Contributes to cAMP-Induced Steroidogenesis in MA-10 Leydig Cells, Jacques J. Tremblay, Zoheir B. Demmouche, Endocrines, 2022, 10.3390/endocrines3030037
  • New insights into the regulation of mammalian sex determination and male sex differentiation., Tremblay JJ, Silversides DW, Viger RS, Vitamins and hormones, 2005, 10.1016/s0083-6729(05)70013-3
  • Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA, Boilard, Eric, Gelb, Michael H., Soulet, Denis, Provost, Patrick, Pouliot, Marc, Lambeau, Gerard, Poubelle, Patrice E., Tremblay, Jacques J., Allaeys, Isabelle, Rousseau, Matthieu, Rollet-Labelle, Emmanuelle, Levesque, Tania, Mendoza-Villarroel, Raifish E., Laffont, Benoit, Cloutier, Nathalie, Belleannee, Clemence, Bollinger, James, Boudreau, Luc H., Duchez, Anne-Claire, Proceedings of the National Academy of Sciences, 2015, 10.1073/PNAS.1507905112
  • FOXA3 Is Expressed in Postnatal Leydig Cells and Regulates Pdgfra Gene Transcription, Tremblay, Jacques J., Brousseau, Catherine, Bergeron, Francis, Garon, Gabriel, Biology of Reproduction, 2011
  • Expression of ladybird-like homeobox 2 (LBX2) during ovarian development and folliculogenesis in the mouse., Tremblay JJ, Robert NM, Moisan V, Journal of molecular histology, 2010, 10.1007/s10735-010-9291-5
  • Transcription Factors as Regulators of Gene Expression During Leydig Cell Differentiation and Function, , The Leydig Cell in Health and Disease, 2007, 10.1007/978-1-59745-453-7_23
  • A 35-bp Conserved Region Is Crucial for Insl3 Promoter Activity in Mouse MA-10 Leydig Cells, Jacques J. Tremblay, Nicholas M. Robert, Kenley Joule Pierre, Xavier C. Giner, International Journal of Molecular Sciences, 2022, 10.3390/ijms232315060
  • Functional cooperation between GATA factors and cJUN on the star promoter in MA-10 Leydig cells., Jacques J. Tremblay, Viger RS, Bergeron F, Luc J. Martin, Journal of andrology, 2012, 10.2164/jandrol.110.012039
  • In Vitro Exposure of Leydig Cells to an Environmentally Relevant Mixture of Organochlorines Represses Early Steps of Steroidogenesis, Tremblay, Jacques J., Bailey, Janice L., Njembele, Annick N. Enangue, Biology of Reproduction, 2014, 10.1095/BIOLREPROD.113.116368
  • A homeodomain gene Ptx3 has highly restricted brain expression in mesencephalic dopaminergic neurons, Burbach, JPH, Drouin, J, Wolterink, G, vanderKleij, AAM, Cox, JJ, Tremblay, JJ, Lanctot, C, vanSchaick, HSA, Smidt, MP, Proceedings of the National Academy of Sciences, 1997, 10.1073/PNAS.94.24.13305
  • Expression of the ladybird-like homeobox 2 (LBX2) factor during ovarian development in the mouse, Tremblay, Jacques J., Bomgardner, Damela, Moisan, Vanessa, Biology of Reproduction, 2007, 10.1093/BIOLREPROD/77.S1.207C
  • Novel transcriptional cooperation between the orphan nuclear receptor Nur77 and AP-1 family members on the star promoter, Tremblay, JJ, Martin, LJ, Biology of Reproduction, 2005
  • cAMP-induced expression of the orphan nuclear receptor Nur77 in MA-10 Leydig cells involves a CaMKI pathway., Tremblay JJ, El-Asmar B, Boucher N, Martin LJ, Journal of andrology, 2009, 10.2164/jandrol.108.006387
  • Nuclear receptors, testosterone, and posttranslational modifications in human INSL3 promoter activity in testicular Leydig cells., Laguë E, Robert NM, Tremblay JJ, Annals of the New York Academy of Sciences, 2009, 10.1111/j.1749-6632.2008.03807.x
  • The Transcription Factor MEF2 Is a Novel Regulator of Gsta Gene Class in Mouse MA-10 Leydig Cells, Tremblay, Jacques J., Bergeron, Francis, Di-Luoffo, Mickael, Brousseau, Catherine, Endocrinology, 2015, 10.1210/EN.2015-1500
  • The INSL3 gene is a direct target for the orphan nuclear receptor, COUP-TFII, in Leydig cells, Tremblay, Jacques J., Brousseau, Catherine, Giner, Xavier C., Camire, Etienne, Di-Luoffo, Mickael, Mendoza-Villarroel, Raifish E., Journal of Molecular Endocrinology, 2014, 10.1530/JME-13-0290
  • Hormones and Signaling Pathways Involved in the Stimulation of Leydig Cell Steroidogenesis, Jacques J. Tremblay, Kenley Joule Pierre, Karine de Mattos, Endocrines, 2023, 10.3390/endocrines4030041
  • Protein kinase A-dependent cooperation between GATA and CCAAT/enhancer-binding protein transcription factors regulates steroidogenic acute regulatory protein promoter activity., Viger RS, Hamel F, Tremblay JJ, Endocrinology, 2002, 10.1210/en.2002-220413
  • Transcription factor GATA-4 is activated by phosphorylation of serine 261 via the cAMP/protein kinase a signaling pathway in gonadal cells., Viger RS, Tremblay JJ, The Journal of biological chemistry, 2003, 10.1074/jbc.m213149200
  • The transcription factor KLF6 is expressed in somatic cells and in a subpopulation of germ cells during mouse testicular development, Tremblay, Jacques, Tremblay, Maxime, Robert, Nicholas, Biology of Reproduction, 2007, 10.1093/BIOLREPROD/77.S1.224B
  • GATA factors and the nuclear receptors, steroidogenic factor 1/liver receptor homolog 1, are key mutual partners in the regulation of the human 3beta-hydroxysteroid dehydrogenase type 2 promoter., Viger RS, Tremblay JJ, Simard J, Robert NM, Taniguchi H, Martin LJ, Molecular endocrinology, 2005, 10.1210/me.2004-0257
  • The human 3beta-hydroxysteroid dehydrogenase/Delta5-Delta4 isomerase type 2 promoter is a novel target for the immediate early orphan nuclear receptor Nur77 in steroidogenic cells., Tremblay JJ, Martin LJ, Endocrinology, 2005, 10.1210/en.2004-0859
  • MEF2 Cooperates With Forskolin/cAMP and GATA4 to Regulate Star Gene Expression in Mouse MA-10 Leydig Cells, Tremblay, Jacques J., Paradis, Elise, Di-Luoffo, Mickael, Daems, Caroline, Endocrinology, 2015, 10.1210/EN.2014-1964
  • The pan-pituitary activator of transcription, Ptx1 (pituitary homeobox 1), acts in synergy with SF-1 and Pit1 and is an upstream regulator of the lim-homeodomain gene Lim3/Lhx3, Drouin, J, Lanctot, C, Tremblay, JJ, Molecular Endocrinology, 1998, 10.1210/ME.12.3.428
  • Insights Into the Roles of GATA Factors in Mammalian Testis Development and the Control of Fetal Testis Gene Expression., Jacques J. Tremblay, de Mattos K, Viger RS, Frontiers in endocrinology, 2022, 10.3389/fendo.2022.902198
  • Differential Response of Transcription Factors to Activated Kinases in Steroidogenic and Non-Steroidogenic Cells, Jacques J. Tremblay, Kenley Joule Pierre, International Journal of Molecular Sciences, 2022, 10.3390/ijms232113153
  • Characterization of the platelet-derived growth factor receptor alpha (PDGF-R alpha) promoter in mouse Leydig cells, Tremblay, Jacques, Dube, Charlotte, Biology of Reproduction, 2007
  • Isolation of the rat Nur77 promoter and characterization of its regulatory elements in testicular Leydig cells, Tremblay, JJ, Boucher, N, Biology of Reproduction, 2005
  • Transcription of platelet-derived growth factor receptor α in Leydig cells involves specificity protein 1 and 3., Jacques J. Tremblay, Bagu ET, Bergeron F, Journal of molecular endocrinology, 2011, 10.1530/jme-10-0145
  • DOES ENDOCRINE DISRUPTION CAUSE CRYPTORCHIDISM: WHERE DO WE STAND?, Lague, Eric, Tyre, Madeline, Tremblay, Jacques J., Journal of Andrology, 2011
  • The orphan nuclear receptor NR4A1 regulates insulin-like 3 gene transcription in Leydig cells., Tremblay JJ, Martin LJ, Robert NM, Biology of reproduction, 2006, 10.1095/biolreprod.105.044560
  • Estradiol represses insulin-like 3 expression and promoter activity in MA-10 Leydig cells., Tremblay JJ, Laguë E, Toxicology, 2009, 10.1016/j.tox.2009.01.013
  • A STAR for the ages: a 30-year historical perspective of the role of transcription factors in the regulation of steroidogenic acute regulatory gene expression, Jacques J Tremblay, Marie France Bouchard, Robert S Viger, Journal of Endocrinology, 2024, 10.1530/JOE-24-0087
  • IL-6 downregulates transcription of NTPDase2 via specific promoter elements., Dranoff JA, Sévigny J, Sheung N, Tremblay JJ, Lavoie EG, Yu J, American journal of physiology. Gastrointestinal and liver physiology, 2008, 10.1152/ajpgi.00208.2007
  • Upstream stimulatory factor 1 (USF1) and USF2 are expressed in the mouse testis: Implications for testicular gene expression, Tremblay, JJ, Pons, E, Biology of Reproduction, 2005
  • The PTX family of homeodomain transcription factors during pituitary developments, Tremblay, JJ, Lanctot, C, Lamonerie, T, Lamolet, B, Drouin, J, Molecular and Cellular Endocrinology, 1998, 10.1016/S0303-7207(98)00026-4
  • Pitx1 in vivo promoter activity and mechanisms of positive autoregulation., Drouin J, Gauthier Y, Lanctôt C, Marcil A, Paradis FW, Tremblay JJ, Goodyer CG, Neuroendocrinology, 2003, 10.1159/000072794
  • Egr-1 is a downstream effector of GnRH and synergizes by direct interaction with Ptx1 and SF-1 to enhance luteinizing hormone beta gene transcription, Drouin, J, Tremblay, JJ, Molecular and Cellular Biology, 1999, 10.1128/MCB.19.4.2567
  • Calcium-dependent Nr4a1 expression in mouse Leydig cells requires distinct AP1/CRE and MEF2 elements, Tremblay, Jacques J., Robert, Nicholas M., Abdou, Houssein S., Journal of Molecular Endocrinology, 2016, 10.1530/JME-15-0202
  • Transcription factor GATA-4 enhances Mullerian inhibiting substance gene transcription through a direct interaction with the nuclear receptor SF-1, Viger, RS, Tremblay, JJ, Molecular Endocrinology, 1999, 10.1210/ME.13.8.1388
  • What signals testis descent?, Tremblay JJ, Biology of reproduction, 2010, 10.1095/biolreprod.110.087197
  • THE INSL3 GENE IS A DIRECT TARGET FOR THE NUCLEAR RECEPTOR COUP-TFII IN MA-10 LEYDIG CELLS, Tremblay, Jacques J., Brousseau, Catherine, Camire, Etienne, Mendoza, Raifish, Andrology, 2013
  • Identification of novel genes and pathways regulated by the orphan nuclear receptor COUP-TFII in mouse MA-10 Leydig cells†., Jacques J. Tremblay, Viger RS, Talbot P, de Mattos K, Mendoza-Villarroel RE, Mehanovic S, Biology of reproduction, 2021, 10.1093/biolre/ioab131
  • The Nuclear Receptor COUP-TFII Regulates Amhr2 Gene Transcription via a GC-Rich Promoter Element in Mouse Leydig Cells, Jacques J Tremblay, Robert S Viger, Raifish E Mendoza-Villarroel, Samir Mehanovic, Journal of the Endocrine Society, 2019, 10.1210/js.2019-00266
  • Expression of the Ladybird-like homeobox 2 transcription factor in the developing mouse testis and epididymis., Tremblay JJ, Bomgardner D, Moisan V, BMC developmental biology, 2008, 10.1186/1471-213x-8-22
  • The Calcium Signaling Pathway Regulates Leydig Cell Steroidogenesis through a Transcriptional Cascade Involving the Nuclear Receptor NR4A1 and the Steroidogenic Acute Regulatory Protein, Tremblay, Jacques J., Villeneuve, Gabrielle, Abdou, Houssein S., Endocrinology, 2013, 10.1210/EN.2012-1767
  • Molecular regulation of steroidogenesis in endocrine Leydig cells, Tremblay, Jacques J., Steroids, 2015, 10.1016/J.STEROIDS.2015.08.001
  • Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA (vol 112, pg E3564, 2015), Boilard, Eric, Gelb, Michael H., Soulet, Denis, Provost, Patrick, Pouliot, Marc, Lambeau, Gerard, Poubelle, Patrice E., Tremblay, Jacques J., Allaeys, Isabelle, Rousseau, Matthieu, Rollet-Labelle, Emmanuelle, Levesque, Tania, Mendoza-Villarroel, Raifish E., Laffont, Benoit, Cloutier, Nathalie, Belleannee, Clemence, Bollinger, James, Naika, Gajendra S., Boudreau, Luc H., Duchez, Anne-Claire, Proceedings of the National Academy of Sciences, 2015, 10.1073/PNAS.1522504112
  • Dynamic Expression of the Homeobox Factor PBX1 during Mouse Testis Development, Jacques J. Tremblay, Catherine Brousseau, Vanessa Moisan, Endocrines, 2022, 10.3390/endocrines3010002
  • Nuclear receptor Dax-1 represses the transcriptional cooperation between GATA-4 and SF-1 in Sertoli cells., Viger RS, Tremblay JJ, Jacques J. Tremblay, Biology of reproduction, 2001, 10.1095/biolreprod64.4.1191
  • The orphan nuclear receptor NUR77 regulates hormone-induced StAR transcription in Leydig cells through cooperation with Ca2+/calmodulin-dependent protein kinase I., Tremblay JJ, Brousseau C, Boucher N, Martin LJ, Molecular endocrinology (Baltimore, Md.), 2008, 10.1210/me.2007-0370
  • Growth Hormone-induced STAT5B Regulates Star Gene Expression Through a Cooperation With cJUN in Mouse MA-10 Leydig Cells, Jacques J Tremblay, Catherine Brousseau, Karine de Mattos, Raifish E Mendoza-Villarroel, Kenley Joule Pierre, Samir Mehanovic, Nicholas M Robert, Francis Bergeron, Pierre-Olivier Hébert-Mercier, Endocrinology, 2022, 10.1210/endocr/bqab267
  • FOG-2 and DAX-1 are negative modulators of GATA-4/SF-1 synergism in Sertoli cells, Viger, RS, Tremblay, JJ, Biology of Reproduction, 2000
  • Friend of GATA (FOG)-1 and FOG-2 differentially repress the GATA-dependent activity of multiple gonadal promoters., Viger RS, Tremblay JJ, Robert NM, Endocrinology, 2002, 10.1210/en.2002-220280
  • ERK5 Cooperates With MEF2C to Regulate Nr4a1 Transcription in MA-10 and MLTC-1 Leydig Cells, Jacques J Tremblay, Robert S Viger, Clémence Belleannée, Gabriel Henrique Campolina-Silva, Félix-Olivier Dumas, Karine de Mattos, Endocrinology, 2023, 10.1210/endocr/bqad120
  • Transcriptional properties of Ptx1 and Ptx2 isoforms., Drouin J, Goodyer CG, Tremblay JJ, Neuroendocrinology, 2000, 10.1159/000054547
  • Ptx1 regulates SF-1 activity by an interaction that mimics the role of the ligand-binding domain, Drouin, J, Gauthier, Y, Marcil, A, Tremblay, JJ, The EMBO Journal, 1999, 10.1093/EMBOJ/18.12.3431
  • Nuclear receptors in Leydig cell gene expression and function., Tremblay JJ, Martin LJ, Biology of reproduction, 2010, 10.1095/biolreprod.110.083824
  • Modulation of endogenous GATA-4 activity reveals its dual contribution to Mullerian inhibiting substance gene transcription in sertoli cells, Viger, RS, Robert, NM, Tremblay, JJ, Molecular Endocrinology, 2001, 10.1210/ME.15.9.1636
  • MEF2 and NR2F2 cooperate to regulate Akr1c14 gene expression in mouse MA-10 Leydig cells, Tremblay, J. J., Brousseau, C., Di-Luoffo, M., Andrology, 2016, 10.1111/ANDR.12150
  • A Cell-Autonomous Molecular Cascade Initiated by AMP-Activated Protein Kinase Represses Steroidogenesis, Tremblay, Jacques J., Bergeron, Francis, Abdou, Houssein S., Molecular and Cellular Biology, 2014, 10.1128/MCB.00734-14
  • Mechanism of Action of an Environmentally Relevant Organochlorine Mixture in Repressing Steroid Hormone Biosynthesis in Leydig Cells , Jacques J. Tremblay, Janice L. Bailey, Zoheir B. Demmouche, Annick N. Enangue Njembele, International Journal of Molecular Sciences, 2022, 10.3390/ijms23073997
  • Transcriptional regulation of INSL3 expression in testicular Leydig cells, Tremblay, JJ, Robert, NM, Biology of Reproduction, 2005
  • Antagonistic effects of testosterone and the endocrine disruptor mono-(2-ethylhexyl) phthalate on INSL3 transcription in Leydig cells., Tremblay JJ, Laguë E, Endocrinology, 2008, 10.1210/en.2008-0310
  • A New Leydig Cell–Exclusive Cre Line Allows Lineage Tracing of Fetal and Adult Leydig Cell Populations in the Mouse, Jacques J Tremblay, Shirley Ferrier-Tarin, Nicholas M Robert, Endocrinology, 2025, 10.1210/endocr/bqaf012
  • Hypoxia-inducible factor-1alpha is constitutively expressed in murine Leydig cells and regulates 3beta-hydroxysteroid dehydrogenase type 1 promoter activity., Turner TT, Palmer LA, Reardon MA, Tremblay JJ, Woodson RI, Kirby JL, Lysiak JJ, Journal of andrology, 2009, 10.2164/jandrol.108.006155
  • Transcription Factors in Leydig Cells, Jacques J. Tremblay, Karine de Mattos, 2025, 10.1007/978-3-031-96376-6_9
  • Phosphorylation of GATA4 serine 105 but not serine 261 is required for testosterone production in the male mouse, Viger, R. S., Pilon, N., Tremblay, J. J., Brousseau, C., Souchkova, O., Taniguchi, H., Bouchard, M. F., Sab, A. Boulende, Bergeron, F., Andrology, 2019, 10.1111/ANDR.12601
  • Mechanisms of MEHP Inhibitory Action and Analysis of Potential Replacement Plasticizers on Leydig Cell Steroidogenesis, Jacques J. Tremblay, Annick N. Enangue Njembele, International Journal of Molecular Sciences, 2021, 10.3390/ijms222111456
  • Expression of Nur77 and its target genes StAR and HSD3B2 in endometrial cancer cell lines: Implication for local steroid production, Tremblay, JJ, Vaillant, MJ, Biology of Reproduction, 2005
  • A mutated form of steroidogenic factor 1 (SF-1 G35E) that causes sex reversal in humans fails to synergize with transcription factor GATA-4., Viger RS, Tremblay JJ, The Journal of biological chemistry, 2003, 10.1074/jbc.m305485200
  • Role of the GATA family of transcription factors in andrology., Tremblay JJ, Robert NM, Taniguchi H, Viger RS, Journal of andrology, 2004, 10.1002/j.1939-4640.2004.tb02813.x
  • GATA factors differentially activate multiple gonadal promoters through conserved GATA regulatory elements., Viger RS, Tremblay JJ, Endocrinology, 2001, 10.1210/endo.142.3.7995
  • Transcription Factors in the Regulation of Leydig Cell Gene Expression and Function., Jacques J. Tremblay, Viger RS, de Mattos K, Frontiers in endocrinology, 2022, 10.3389/fendo.2022.881309
  • MEF2 Is Restricted to the Male Gonad and Regulates Expression of the Orphan Nuclear Receptor NR4A1, Tremblay, Jacques J., Brousseau, Catherine, Martin, Luc J., Daems, Caroline, Molecular Endocrinology, 2014, 10.1210/ME.2013-1407
  • A Short Promoter Region Containing Conserved Regulatory Motifs Is Required for Steroidogenic Acute Regulatory Protein (Star) Gene Expression in the Mouse Testis, Robert S. Viger, Jacques J. Tremblay, Julia Picard, Marie France Bouchard, International Journal of Molecular Sciences, 2022, 10.3390/ijms231912009
  • Glucocorticoids antagonize cAMP-induced Star transcription in Leydig cells through the orphan nuclear receptor NR4A1., Tremblay JJ, Martin LJ, Journal of molecular endocrinology, 2008, 10.1677/jme-07-0145
  • The nuclear receptors NUR77 and SF1 play additive roles with c-JUN through distinct elements on the mouse Star promoter., Tremblay JJ, Martin LJ, Journal of molecular endocrinology, 2009, 10.1677/jme-08-0095
  • Novel roles for GATA transcription factors in the regulation of steroidogenesis., Viger RS, Tremblay JJ, The Journal of steroid biochemistry and molecular biology, 2003, 10.1016/s0960-0760(03)00211-5
  • The nuclear receptors SF1 and COUP-TFII cooperate on the Insl3 promoter in Leydig cells., Tremblay JJ, Girard MJ, Robert NM, Pierre KJ, Di-Luoffo M, Reproduction (Cambridge, England), 2022, 10.1530/rep-22-0109
  • Expression of the ladybird-like homeobox2 (Lbx2) factor during mouse testicular and epididymal development, Tremblay, JJ, Bomgardner, D, Moisan, V, Biology of Reproduction, 2005
  • The Nuclear Receptor NR2F2 Activates Star Expression and Steroidogenesis in Mouse MA-10 and MLTC-1 Leydig Cells, Tremblay, Jacques J., Brousseau, Catherine, Martin, Luc J., Robert, Nicholas M., Mendoza-Villarroel, Raifish E., Biology of Reproduction, 2014, 10.1095/BIOLREPROD.113.115790
  • Transient dwarfism and hypogonadism in mice lacking Otx1 reveal prepubescent stage-specific control of pituitary levels of GH, FSH and LH, Simeone, A, Brulet, P, Drouin, J, Macchia, V, Corte, G, Macchia, PE, Mariano, A, Lazzaro, D, di Carlo, A, Tremblay, JJ, Avantaggiato, V, Tuorto, F, Mazan, S, Acampora, D, Development, 1998, 10.1242/DEV.125.7.1229
  • Transcriptional cooperation between NF-kappaB p50 and CCAAT/enhancer binding protein beta regulates Nur77 transcription in Leydig cells., Tremblay JJ, Giner XC, El-Asmar B, Journal of molecular endocrinology, 2009, 10.1677/jme-08-0016
  • Comprehensive and Quantitative Analysis of the Changes in Proteomic and Phosphoproteomic Profiles during Stimulation and Repression of Steroidogenesis in MA-10 Leydig Cells, Jacques J. Tremblay, Zoheir B. Demmouche, International Journal of Molecular Sciences, 2022, 10.3390/ijms232112846
  • The ladybird-like homeobox 2 (Lbx2) gene shows region-specific expression within the mouse epididymis, Tremblay, JJ, Moisan, V, Biology of Reproduction, 2004
  • KLF6 cooperates with NUR77 and SF1 to activate the human INSL3 promoter in mouse MA-10 leydig cells, Tremblay, Jacques J., Bergeron, Francis, Robert, Nicholas M., Mendoza-Villarroel, Raifish E., Tremblay, Maxime A., Journal of Molecular Endocrinology, 2016, 10.1530/JME-15-0139
  • The nuclear receptors SF1 and LRH1 are expressed in endometrial cancer cells and regulate steroidogenic gene transcription by cooperating with AP-1 factors., Tremblay JJ, Brousseau C, Robert NM, Vaillant MJ, Bergeron F, Dubé C, Cancer letters, 2009, 10.1016/j.canlet.2008.10.008
  • Chicken ovalbumin upstream promoter transcription factor type II interacts and functionally cooperates with GATA4 to regulate anti‐Müllerian hormone receptor type 2 transcription in mouse MA‐10 Leydig cells, Jacques J. Tremblay, Robert S. Viger, Kenley Joule Pierre, Samir Mehanovic, Andrology, 2022, 10.1111/andr.13266

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2020/08
  • Kenley Joule Pierre - Doctorat - En cours
  • Léa Lafranchise - Maîtrise avec mémoire - En cours
  • Samir Mehanovic - Doctorat - 2021/05
  • Oona Delmas - Maîtrise avec mémoire - 2021/05
  • Shirley Ferrier Tarin - Maîtrise avec mémoire - 2023/05
  • Zoheir Benaoumer Demmouche - Doctorat - 2023/09
  • Karine De Mattos - Doctorat - 2024/09
  • Laurie Boudreau - Maîtrise avec mémoire - 2025/01

Encadrement d'étudiant(e)s

Direction de recherche dans les domaines suivants :

  • Biologie cellulaire et moléculaire
  • Médecine moléculaire

En savoir plus sur les programmes

Disponibilité d'encadrement d'étudiant(e)s

Ce (cette) professeur(e) est présentement à la recherche d'étudiant(e)s.

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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Vice-décanat à la recherche et à l'innovation

Pavillon Ferdinand-Vandry
Université Laval
1050, avenue de la Médecine, local 4623
Québec (Québec) G1V 0A6
Canada

Renseignements - Secrétariat
418 656-2690
secretariatvdri@fmed.ulaval.ca

Catherine Mercier
Vice-doyenne à la recherche et à l'innovation