Vincent Fradet

Médecin clinicien enseignant agrégé

Vincent.Fradet@fmed.ulaval.ca

Département de chirurgie

Centre de recherche sur le cancer

Centre de recherche du CHU de Québec - Université Laval

Nutrition, santé et société (NUTRISS)

Partager la fiche :

Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Bioinformatique / données massives (big data)

Oncologie

Santé cardiovasculaire, respiratoire et métabolisme

Santé des populations et pratiques optimales en santé

Domaines et intérêts de recherche du (de la) professeur(e) :

Cancer

Cancer la prostate
Cancer de l'appareil urinaire
Environnement et cancer
Nutrition et cancer
Diagnostic et détection du cancer
Déterminants sociaux du cancer
Carcinogénèse

Nutrition et métabolisme

Pathologies urogénitales
Système génito-urinaire
Nutriments
Nutrition
Métabolisme
Produits nutraceutiques et aliments fonctionnels
Désordres métaboliques
Régulation hormonale
Hormones et facteurs de croissance

Santé des populations

Habitudes de vie et santé
Prévention en santé
Pharmaco-épidémiologie
Déterminants sociaux de la santé

Information

Développement de logiciels

Communication

Projets de recherche

Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
Les habitudes de vie en cancer de la prostate au coeur d’une médecine personnalisée - Fonds de recherche du Québec - Santé - Chercheurs-boursiers cliniciens - Juniors 1 et 2, Seniors, chercheur principal - 2021-07-01 au 2024-06-30
Institut sur la nutrition et les aliments fonctionnels (INAF) - Institut national de recherche scientifique (INRS), Fonds de recherche du Québec - Nature et technologies, Université Laval - Fonds internes, Université McGill, Université du Québec à Rimouski, Université de Sherbrooke - Regroupements stratégiques NT, co-chercheur - 2017-04-01 au 2024-03-31
Habitudes de vie, biomarqueurs et risque de cancer de la prostate - Fondation de l'Université Laval, chercheur principal - 2022-04-01 au 2024-03-31
En route towards prebiotic clinical trials for enhancement of immunotherapies in bladder and prostate cancers - The W. Garfield Weston Foundation - Transformational Research, chercheur principal - 2020-06-01 au 2023-05-31
Project MEDTEQ-CaptoMD - CHU de Québec – Université Laval – CHUL - Développement de la recherche (FC), chercheur principal - 2022-02-11 au 2023-03-30
What are my options? A feasibility study of a personalized primary prevention strategy for women and men at high risk of breast and prostate cancer - Instituts de recherche en santé du Canada, Fondation du cancer du sein du Québec, Société canadienne du cancer - Initiative SCC/IC-IRSC en prévention primaire du cancer, co-chercheur - 2022-01-15 au 2023-01-14
Impact of lifestyle on gut barrier function, bacterial translocation and risk of prostate cancer - The W. Garfield Weston Foundation, chercheur principal - 2020-09-01 au 2022-08-31
Banque de tissus et de données médicales SurMAGE (Biobanque SurMAGE) - CHU de Québec – Université Laval – CHUL - Développement de la recherche (FC), chercheur principal - 2021-03-01 au 2022-02-28
Interaction between environment, diet, physical activities, and sexual habits, in the risk of prostate cancer. Validation of biomarkers to personnalize preventive interventions. - Société de recherche sur le cancer - Compétition GRePEC (SRC/FRSQ/MDEIE), chercheur principal - 2012-10-01 au 2021-12-31
(2015-386) ("Project Arms"): 1) The Role of ... in Cardiovascular Disease - A Longitudinal Prostate Cancer Study ("RADICAL PC1") and 2) A Randomized Intervention for Cardiovascular and Lifestyle Risk Factors in ... - Hamilton Health Sciences Corporation, Cancer de la prostate Canada, chercheur principal - 2016-04-01 au 2021-12-25
Prebiotics to enhance immunotherapy response in bladder cancer - The W. Garfield Weston Foundation - 2018 Proof-of-Principle Grant Call, co-chercheur - 2019-01-01 au 2021-07-31
Impact du déploiement en clinique multidisciplinaire du cancer de la prostate de CaptoMD, une innovation technologique dédiée à la clinique en oncologie - Ministère de l'Économie et de l'Innovation - Programme de soutien aux organismes de recherche et d’innovation (PSO) - Recherche-innovation - Volet 2a, chercheur principal - 2019-04-01 au 2021-04-01
Territorialiser les systèmes alimentaires : une révolution pour la planète et la santé durable - Alliance santé Québec (AsQ), co-chercheur - 2020-04-01 au 2021-03-31
Toward nutritional and epigenomic interventions in prostate cancer prevention and management - Instituts de recherche en santé du Canada - Fonctionnement: Subvention de promotion de l’impact - CCREES, co-chercheur - 2017-10-01 au 2020-09-30

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Publications

Development and Comparability of a Short Food-Frequency Questionnaire to Assess Diet in Prostate Cancer Patients: The Role of Androgen Deprivation Therapy in CArdiovascular Disease – A Longitudinal Prostate Cancer Study (RADICAL PC) Substudy, Nevena Savija, Darryl P Leong, Jehonathan Pinthus, Sarah Karampatos, Bobby Shayegan, Rajibul Mian, Sumathy Rangarajan, Vincent Fradet, Russell J de Souza, Andrew Mente, Mahshid Dehghan, Current Developments in Nutrition, 2021, 10.1093/cdn/nzab106
Omega-3 Eicosapentaenoic Acid Reduces Prostate Tumor Vascularity, Nikunj Gevariya, Gabriel Lachance, Karine Robitaille, Charles Joly Beauparlant, Lisanne Beaudoin, Éric Fournier, Yves Fradet, Arnaud Droit, Pierre Julien, André Marette, Alain Bergeron, Vincent Fradet, Molecular Cancer Research, 2021, 10.1158/1541-7786.MCR-20-0316
The neutrophil-to-lymphocyte ratio (NLR) as a predictive marker of response to abiraterone acetate: A retrospective analysis of the COU302 study, T. Loubersac, M. Nguile-Makao, F. Pouliot, V. Fradet, P. Toren, European Urology Supplements, 2019, 10.1016/s1569-9056(19)30110-1
Omega-3 fatty acids decrease prostate cancer progression associated with an anti-tumor immune response in eugonadal and castrated mice, Nikunj Gevariya, Marjorie Besançon, Karine Robitaille, Valérie Picard, Lamoussa Diabaté, Anwar Alesawi, Pierre Julien, Yves Fradet, Alain Bergeron, Vincent Fradet, The Prostate, 2019, 10.1002/pros.23706
Omega-3 Fatty Acids Survey in Men under Active Surveillance for Prostate Cancer: from Intake to Prostate Tissue Level, Moussa, H., Nguile-Makao, M., Robitaille, K., Guertin, M.-H., Allaire, J., Pelletier, J.-F., Moreel, X., Gevariya, N., Diorio, C., Desmeules, P., Têtu, B., Lamarche, B., Julien, P., Fradet, V., Nutrients, 2019, 10.3390/nu11071616
Use and duration of antibiotic prophylaxis and the rate of urinary tract infection after radical cystectomy for bladder cancer: Results of a multicentric series, Haider, M., Ladurner, C., Mayr, R., Tandogdu, Z., Fritsche, H.-M., Fradet, V., Comploj, E., Pycha, A., Lemire, F., Lacombe, L., Fradet, Y., Toren, P., Lodde, M., Urologic Oncology: Seminars and Original Investigations, 2019, 10.1016/j.urolonc.2019.01.017
Prognostic value of urinary prostate cancer antigen 3 (PCA3) during active surveillance of patients with low-risk prostate cancer receiving 5α-reductase inhibitors, Vincent Fradet, Paul Toren, Molière Nguile-Makao, Michele Lodde, Jérome Lévesque, Caroline Léger, André Caron, Alain Bergeron, Tal Ben-Zvi, Louis Lacombe, Frédéric Pouliot, Rabi Tiguert, Thierry Dujardin, Yves Fradet, BJU International, 2018, 10.1111/bju.14041
Effects of concentrated long-chain omega-3 polyunsaturated fatty acid supplementation before radical prostatectomy on prostate cancer proliferation, inflammation, and quality of life: Study protocol for a phase IIb, randomized, double-blind, placebo-controlled trial, Guertin, M.-H., Robitaille, K., Pelletier, J.-F., Duchesne, T., Julien, P., Savard, J., Bairati, I., Fradet, V., BMC Cancer, 2018, 10.1186/s12885-017-3979-9
Increased Prostate Cancer Glucose Metabolism Detected by ¹⁸F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Localised Gleason 8–10 Prostate Cancers Identifies Very High–risk Patients for Early Recurrence and Resistance to Castration, Lavallée, E., Bergeron, M., Buteau, F.-A., Blouin, A.-C., Duchesnay, N., Dujardin, T., Tiguert, R., Lacombe, L., Fradet, V., Makao-Nguile, M., Fradet, Y., Beauregard, J.-M., Pouliot, F., European Urology Focus, 2018, 10.1016/j.euf.2018.03.008
Urology residents on call: Investigating the workload and relevance of calls, Thériault, B., Marceau-Grimard, M., Blais, A.-S., Fradet, V., Moore, K., Cloutier, J., Canadian Urological Association Journal, 2018, 10.5489/cuaj.4333
Metabolic Imaging of Prostate Cancer Reveals Intrapatient Intermetastasis Response Heterogeneity to Systemic Therapy, Fannie Morin, Jean-Mathieu Beauregard, Michelle Bergeron, Molière Nguile Makao, Louis Lacombe, Vincent Fradet, Yves Fradet, Frédéric Pouliot, European Urology Focus, 2017, 10.1016/j.euf.2017.02.007
Preoperative nutritional factors and outcomes after radical cystectomy: A narrative review, Allaire, J., Ben-Zvi, T., Lamarche, B., Robitaille, K., Fradet, Y., Lacombe, L., Fradet, V., Canadian Urological Association Journal, 2017, 10.5489/cuaj.4471
Prospective Evaluation of Nutritional Factors to Predict the Risk of Complications for Patients Undergoing Radical Cystectomy: A Cohort Study, Allaire, J., Léger, C., Ben-Zvi, T., Nguilé-Makao, M., Fradet, Y., Lacombe, L., Fradet, V., Nutrition and Cancer, 2017, 10.1080/01635581.2017.1367941
Validation of the French-Canadian version of the Expanded Prostate Cancer Index Composite (EPIC) in a French-Canadian population, Vigneault, É., Savard, J., Savard, M.-H., Ivers, H., Després, P., Foster, W., Martin, A.-G., Fradet, V., Canadian Urological Association Journal, 2017, 10.5489/cuaj.4428
Assessing Cancer Risk on Novel 29 MHz Micro-Ultrasound Images of the Prostate: Creation of the Micro-Ultrasound Protocol for Prostate Risk Identification, Ghai, S., Eure, G., Fradet, V., Hyndman, M.E., McGrath, T., Wodlinger, B., Pavlovich, C.P., Journal of Urology, 2016, 10.1016/j.juro.2015.12.093
Phase II drug-metabolizing polymorphisms and smoking predict recurrence of nonâ€"muscle- invasive bladder cancer: A geneâ€"smoking interaction, Lacombe, L., Fradet, V., Levesque, E., Pouliot, F., Larue, H., Bergeron, A., Hovington, H., Caron, A., Nguile-Makao, M., Harvey, M., Fradet, Y., Guillemette, C., Cancer Prevention Research, 2016, 10.1158/1940-6207.CAPR-15-0069
Renal cell carcinoma with thrombus extending to the hepatic veins or right atrium: Operative strategies based on 41 consecutive patients, Gagné-Loranger, M., Lacombe, L., Pouliot, F., Fradet, V., Dagenais, F., European Journal of Cardio-thoracic Surgery, 2016, 10.1093/ejcts/ezw023
Burden of illness of bone metastases in prostate cancer patients in Québec, Canada: A population-based analysis, Perrault, L., Fradet, V., Lauzon, V., Lelorier, J., Mitchell, D., Habib, M., Journal of the Canadian Urological Association, 2015, 10.5489/cuaj.2707
Comparison of digital image analysis and visual scoring of KI-67 in prostate cancer prognosis after prostatectomy, Desmeules, P., Hovington, H., Nguilé-Makao, M., Léger, C., Caron, A., Lacombe, L., Fradet, Y., Têtu, B., Fradet, V., Diagnostic Pathology, 2015, 10.1186/s13000-015-0294-0
FDG-PET/CT for pre-operative staging and prognostic stratification of patients with high-grade prostate cancer at biopsy, Beauregard, J.-M., Blouin, A.-C., Fradet, V., Caron, A., Fradet, Y., Lemay, C., Lacombe, L., Dujardin, T., Tiguert, R., Rimac, G., Bouchard, F., Pouliot, F., Cancer Imaging, 2015, 10.1186/s40644-015-0038-0
Intermittent vs continuous androgen deprivation therapy for prostate cancer, Magnan, S., Zarychanski, R., Pilote, L., Bernier, L., Shemilt, M., Vigneault, E., Fradet, V., Turgeon, A.F., JAMA Oncology, 2015, 10.1001/jamaoncol.2015.2895
Malignant mesothelioma of the tunica vaginalis testis: comprehensive review of literature and case report, Alesawi, A.M., Levesque, J., Fradet, V., Journal of Clinical Urology, 2015, 10.1177/2051415813511082
Validation of the omega-3 fatty acid intake measured by a web-based food frequency questionnaire against omega-3 fatty acids in red blood cells in men with prostate cancer, Allaire, J., Moreel, X., Labonté, M.-E., Léger, C., Caron, A., Julien, P., Lamarche, B., Fradet, V., European Journal of Clinical Nutrition, 2015, 10.1038/ejcn.2015.7
Diagnostic performance of ultrasound for macroscopic hematuria in the era of multidetector computed tomography urography, Rhéaume-Lanoie, J., Lepanto, L., Fradet, V., Billiard, J.-S., Tang, A., Canadian Association of Radiologists Journal, 2014, 10.1016/j.carj.2013.08.001
IL-8 secretion in primary cultures of prostate cells is associated with prostate cancer aggressiveness, Neveu, B., Moreel, X., Deschênes-Rompré, M.-P., Bergeron, A., LaRue, H., Ayari, C., Fradet, Y., Fradet, V., Research and Reports in Urology, 2014, 10.2147/RRU.S58643
Prostatic and dietary omega-3 fatty acids and prostate cancer progression during active surveillance, Moreel, X., Allaire, J., Léger, C., Caron, A., Labonté, M.-È., Lamarche, B., Julien, P., Desmeules, P., Têtu, B., Fradet, V., Cancer Prevention Research, 2014, 10.1158/1940-6207.CAPR-13-0349
Risk factors for bladder cancer recurrence after nephroureterectomy for upper tract urothelial tumors: Results from the Canadian Upper Tract Collaboration, Fradet, V., Mauermann, J., Kassouf, W., Rendon, R., Jacobsen, N., Fairey, A., Izawa, J., Kapoor, A., Black, P., Tanguay, S., Chin, J., So, A., Lattouf, J.-B., Bell, D., Saad, F., Sheyegan, B., Drachenberg, D., Cagiannos, I., Lacombe, L., Urologic Oncology: Seminars and Original Investigations, 2014, 10.1016/j.urolonc.2014.04.006
High level of mature tumor-infiltrating dendritic cells predicts progression to muscle invasion in bladder cancer, Ayari, C., Larue, H., Hovington, H., Caron, A., Bergeron, A., Têtu, B., Fradet, V., Fradet, Y., Human Pathology, 2013, 10.1016/j.humpath.2013.01.014
Reply from Authors re: Martin Spahn, Steven Joniau. Positive surgical margin at radical prostatectomy: Futile or surgeon-dependent predictor of prostate cancer death? Eur Urol 2013;64:26-8: Adjuvant versus salvage radiotherapy in patients with positive surgical margins at radical prostatectomy: That is the question, Mauermann, J., Fradet, V., Fradet, Y., European Urology, 2013, 10.1016/j.eururo.2012.10.047
The impact of solitary and multiple positive surgical margins on hard clinical end points in 1712 adjuvant treatment-naive pT2-4 N0 radical prostatectomy patients, Mauermann, J., Fradet, V., Lacombe, L., Dujardin, T., Tiguert, R., Tetu, B., Fradet, Y., European Urology, 2013, 10.1016/j.eururo.2012.08.002
Green tea for ovarian cancer prevention and treatment: A systematic review of the in vitro, in vivo and epidemiological studies, Trudel, D., Labbé, D.P., Bairati, I., Fradet, V., Bazinet, L., Têtu, B., Gynecologic Oncology, 2012, 10.1016/j.ygyno.2012.04.048
The impact of germline genetic variations in hydroxysteroid (17-beta) dehydrogenases on prostate cancer outcomes after prostatectomy, Audet-Walsh, É., Bellemare, J., Lacombe, L., Fradet, Y., Fradet, V., Douville, P., Guillemette, C., Lévesque, É., European Urology, 2012, 10.1016/j.eururo.2011.12.021
Dietary omega-3 fatty acids, genetic variation and risk of breast and prostate cancers, Mauermann, J., Pouliot, F., Fradet, V., World Review of Nutrition and Dietetics, 2011, 10.1159/000327805
Poor agreement of prostate specific antigen doubling times calculated using ultrasensitive versus standard prostate specific antigen values: Important impact on risk assessment, Reese, A.C., Fradet, V., Whitson, J.M., Davis, C.B., Carroll, P.R., Journal of Urology, 2011, 10.1016/j.juro.2011.07.119
SRD5A polymorphisms and biochemical failure after radical prostatectomy, Audet-Walsh, E., Bellemare, J., Nadeau, G., Lacombe, L., Fradet, Y., Fradet, V., Huang, S.-P., Bao, B.-Y., Douville, P., Girard, H., Guillemette, C., Lévesque, E., European Urology, 2011, 10.1016/j.eururo.2011.06.020
Prostate cancer managed with active surveillance: Role of anatomic MR imaging and MR spectroscopic imaging, Fradet, V., Kurhanewicz, J., Cowan, J.E., Karl, A., Coakley, F.V., Shinohara, K., Carroll, P.R., Radiology, 2010, 10.1148/radiol.10091147
Prostate cancer managed with active surveillance: Role of anatomic MR imaging and MR spectroscopic imaging, Fradet, V., Kurhanewicz, J., Cowan, J.E., Karl, A., Coakley, F.V., Shinohara, K., Carroll, P.R., International Braz J Urol, 2010, 10.1590/S1677-55382010000500019
Urologist density and county-level urologic cancer mortality, Odisho, A.Y., Cooperberg, M.R., Fradet, V., Ahmad, A.E., Carroll, P.R., Journal of Clinical Oncology, 2010, 10.1200/JCO.2009.26.9597
Dietary omega-3 fatty acids, Cyclooxygenase-2 genetic variation, and aggressive prostate cancer risk, Fradet, V., Cheng, L., Casey, G., Witte, J.S., Clinical Cancer Research, 2009, 10.1158/1078-0432.CCR-08-2503
Geographic Distribution of Urologists Throughout the United States Using a County Level Approach, Odisho, A.Y., Fradet, V., Cooperberg, M.R., Ahmad, A.E., Carroll, P.R., Journal of Urology, 2009, 10.1016/j.juro.2008.10.034
Is the Complication Rate of Radical Cystectomy Predictive of the Complication Rate of Other Urological Procedures?, Fradet, V., Allareddy, V., Aaronson, D.S., Konety, B.R., Journal of Urology, 2009, 10.1016/j.juro.2008.11.016
Pathological Outcomes of Candidates for Active Surveillance of Prostate Cancer, Conti, S.L., Dall'Era, M., Fradet, V., Cowan, J.E., Simko, J., Carroll, P.R., Journal of Urology, 2009, 10.1016/j.juro.2008.11.107
Penile sonographic and clinical characteristics in men with peyronie's disease, Smith, J.F., Brant, W.O., Fradet, V., Shindel, A.W., Vittinghoff, E., Chi, T., Huang, Y.-C., Davis, C.B., Conti, S., Lue, T.F., Journal of Sexual Medicine, 2009, 10.1111/j.1743-6109.2009.01438.x
Prospective Assessment of Malnutrition in Urologic Patients, Karl, A., Rittler, P., Buchner, A., Fradet, V., Speer, R., Walther, S., Stief, G.C., Urology, 2009, 10.1016/j.urology.2008.12.037
ω-3 Fatty acids, genetic variants in COX-2 and prostate cancer, Reese, A.C., Fradet, V., Witte, J.S., Journal of Nutrigenetics and Nutrigenomics, 2009, 10.1159/000235565
A delay in radical cystectomy of >3 months is not associated with a worse clinical outcome [2], Fradet, V., Konety, B.R., BJU International, 2008, 10.1111/j.1464-410X.2007.07394_2.x
Re: Results from three municipal hospitals regarding radical cystectomy on elderly patients [1], Fradet, V., Konety, B.R., International Braz J Urol, 2008, 10.1590/S1677-55382008000100014
Management of hepatic granulomatous tuberculosis complicating intravesical BCG for superficial bladder cancer, Fradet, V., Gaudreau, C., Perrotte, P., Côté, J., Paquin, J.-M., Journal of the Canadian Urological Association, 2007
The 2002 AJCC pT2 substages confer no prognostic information on the rate of biochemical recurrence after radical prostatectomy, Chun, F.K.-H., Briganti, A., Lebeau, T., Fradet, V., Steuber, T., Walz, J., Schlomm, T., Eichelberg, C., Haese, A., Erbersdobler, A., McCormack, M., Perrotte, P., Graefen, M., Huland, H., Karakiewicz, P.I., European Urology, 2006, 10.1016/j.eururo.2005.12.009
An epidural abscess following transrectal ultrasound-guided biopsies of the prostate., Fradet, V., McCormack, M., Perrotte, P., Karakiewicz, P., Saad, F., The Canadian journal of urology, 2005
Nuclear factor-κB nuclear localization is predictive of biochemical recurrence in patients with positive margin prostate cancer, Fradet, V., Lessard, L., Bégin, L.R., Karakiewicz, P., Mes Masson, A.-M., Saad, F., Clinical Cancer Research, 2004, 10.1158/1078-0432.CCR-04-0764

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Gabrielle Villeneuve - Maitrîse avec mémoire - En cours
Ruijing Dong - Doctorat - En cours
Amenan Prisca Nadege Kone - Post-doctorat - En cours
Louis-Alexis Porlier - Maitrîse avec mémoire - En cours
Lamoussa Diabaté - Doctorat - En cours
Justine Desrochers-Goyette - Maitrîse avec mémoire - En cours
Abdelkrim Ziad - Doctorat - En cours
Jalal Laaraj - Doctorat - En cours
Xavier-Philippe Légaré - Maitrîse avec mémoire - En cours
Lisanne Beaudoin - Maitrîse avec mémoire - En cours
Roxane Tourigny - Maitrîse avec mémoire - En cours
Parousia Mapepe - Maitrîse avec mémoire - En cours
Janie Allaire - Maitrîse avec mémoire - 2016/01
Nikunj Gevariya - Doctorat - 2019/01

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