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Centre de recherche du CHU de Québec - Université Laval
Centre de recherche sur le cancer
Partager la fiche :
Contribution à la recherche
Axe de recherche de l'Université Laval :
Santé et bien-être durables
Thématiques de recherche de la Faculté de
médecine :
Bioinformatique / données massives (big data)
Oncologie
Domaines et intérêts de recherche du (de la)
professeur(e) :
Cancer
Carcinogénèse
Différenciation cellulaire
Facteurs de croissance
Gène suppresseur
Oncogènes
Signalisation cellulaire et cancer
Cellulaire
Cellule
Chromosome
Gène
Subcellulaire
Acides nucléiques
Génomique et protéomique
Bio-informatique
Génotype et phénotype
Mécanismes biologiques et biochimiques
Projets de recherche
Pathobiology and treatment of the UBTF E210K neuroregression syndrome- National Institute of Health (USA) - Subvention de recherche, University of Memphis, co-chercheur - 2021-07-01 au 2026-06-30
Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval- Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
Mechanism of Ribosomal RNA Gene Silencing and Its Roles in Pluripotency and Cancer- Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2017-04-01 au 2022-03-31
Role of Misshappen (NIK/Msn) kinases and Extended-Synaptotagmins (E-Syts) in Wnt and FGF intracellular signaling pathways.- Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2017-04-01 au 2022-03-31
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Publications
Ribosomal DNA promoter recognition is determined in vivo by cooperation between UBTF1 and SL1 and is compromised in the UBTF-E210K neuroregression syndrome, Michel G. Tremblay, Dany S. Sibai, Melissa Valère, Jean-Clément Mars, Frédéric Lessard, Roderick T. Hori, Mohammad Moshahid Khan, Victor Y. Stefanovsky, Mark S. LeDoux, Tom Moss, PLOS Genetics, 2022, 10.1371/journal.pgen.1009644
Bidirectional cooperation between Ubtf1 and SL1 determines RNA Polymerase I promoter recognition in cell and is negatively affected in the UBTF-E210K neuroregression syndrome, Michel G. Tremblay, Dany S. Sibai, Melissa Valère, Jean-Clément Mars, Frédéric Lessard, Roderick T. Hori, Mohammad M. Khan, Victor Y. Stefanovsky, Mark S. Ledoux, Tom Moss, 2021, 10.1101/2021.06.07.447350
The chemotherapeutic agent CX-5461 irreversibly blocks RNA polymerase I initiation and promoter release to cause nucleolar disruption, DNA damage and cell inviability, Jean-Clément Mars, Michel G Tremblay, Mélissa Valere, Dany S Sibai, Marianne Sabourin-Felix, Frédéric Lessard, Tom Moss, NAR Cancer, 2020, 10.1093/narcan/zcaa032
The Short N-Terminal Repeats of Transcription Termination Factor 1 Contain Semi-Redundant Nucleolar Localization Signals and P19-ARF Tumor Suppressor Binding Sites., , The Yale journal of biology and medicine, 2019
The chromatin landscape of the ribosomal RNA genes in mouse and human, Tom Moss, Jean-Clement Mars, Michel G. Tremblay, Marianne Sabourin-Felix, Chromosome Research, 2019, 10.1007/s10577-018-09603-9
A recurrent de novo missense mutation in UBTF causes developmental neuroregression., Toro C, Hori RT, Malicdan MCV, Tifft CJ, Goldstein A, Gahl WA, Adams DR, Harper F, Wolfe LA, Xiao J, Khan MM, Tian J, Hope KA, Reiter LT, LeDoux MS, Human molecular genetics, 2018, 10.1093/hmg/ddx435
A Deconvolution Protocol for ChIP-Seq Reveals Analogous Enhancer Structures on the Mouse and Human Ribosomal RNA Genes, Jean-Clement Mars, Marianne Sabourin-Felix, Michel G. Tremblay, Tom Moss, G3: Genes|Genomes|Genetics, 2018, 10.1534/g3.117.300225
A unique enhancer boundary complex on the mouse ribosomal RNA genes persists after loss of Rrn3 or UBF and the inactivation of RNA polymerase I transcription, Chelsea Herdman, Jean-Clement Mars, Victor Y. Stefanovsky, Michel G. Tremblay, Marianne Sabourin-Felix, Helen Lindsay, Mark D. Robinson, Tom Moss, PLOS Genetics, 2017, 10.1371/journal.pgen.1006899
Disruption of the UBF gene induces aberrant somatic nucleolar bodies and disrupts embryo nucleolar precursor bodies, Nourdine Hamdane, Michel G. Tremblay, Stefan Dillinger, Victor Y. Stefanovsky, Attila Németh, Tom Moss, Gene, 2017, 10.1016/j.gene.2016.09.013
Loss of all 3 Extended Synaptotagmins does not affect normal mouse development, viability or fertility, Michel G. Tremblay, Tom Moss, Cell Cycle, 2016, 10.1080/15384101.2016.1203494
Extended-Synaptotagmins (E-Syts); the extended story, Chelsea Herdman, Tom Moss, Pharmacological Research, 2016, 10.1016/j.phrs.2016.01.034
Metabolic Labeling in the Study of Mammalian Ribosomal RNA Synthesis, Victor Y. Stefanovsky, Tom Moss, The Nucleolus, 2016, 10.1007/978-1-4939-3792-9_11
Depletion of the cisplatin targeted HMGB-box factor UBF selectively induces p53-independent apoptotic death in transformed cells., Hamdane N, Herdman C, Mars JC, Stefanovsky V, Tremblay MG, Moss T, 2015, 10.18632/oncotarget.4823
Extended Synaptotagmin Interaction with the Fibroblast Growth Factor Receptor Depends on Receptor Conformation, Not Catalytic Activity, Michel G. Tremblay, Chelsea Herdman, François Guillou, Prakash K. Mishra, Joëlle Baril, Sabrina Bellenfant, Tom Moss, Journal of Biological Chemistry, 2015, 10.1074/jbc.M115.656918
A novel role for the Pol I transcription factor UBTF in maintaining genome stability through the regulation of highly transcribed Pol II genes, , Genome research, 2015
In Vitro DNase I Footprinting, Benoît P. Leblanc, Tom Moss, DNA-Protein Interactions, 2015, 10.1007/978-1-4939-2877-4_2
Conditional inactivation of Upstream Binding Factor reveals its epigenetic functions and the existence of a somatic nucleolar precursor body, , PLoS Genetics, 2014
Loss of Extended Synaptotagmins ESyt2 and ESyt3 does not affect mouse development or viability, but in vitro cell migration and survival under stress are affected, , Cell Cycle, 2014
Agonistic and antagonistic roles for TNIK and MINK in non-canonical and canonical Wnt signalling, , PLoS One, 2012
The cellular abundance of the essential transcription termination factor TTF-I regulates ribosome biogenesis and is determined by MDM2 ubiquitinylation, , Nucleic acids research, 2012
The endocytic adapter E-Syt2 recruits the p21 GTPase activated kinase PAK1 to mediate actin dynamics and FGF signalling, , Biology open, 2012
The p21-activated kinase Pak1 regulates induction and migration of the neural crest in Xenopus, , Cell cycle, 2012
DNA methyltransferase inhibition may limit cancer cell growth by disrupting ribosome biogenesis, Tom Moss, Epigenetics, 2011, 10.4161/epi.6.2.13625
A model for the topology of active ribosomal RNA genes, , EMBO reports, 2011
DNA methyltransferase inhibition may limit cancer cell growth by disrupting ribosome biogenesis, , Epigenetics, 2011
Extended-synaptotagmin-2 mediates FGF receptor endocytosis and ERK activation in vivo, , Developmental cell, 2010
The ARF tumor suppressor controls ribosome biogenesis by regulating the RNA polymerase I transcription factor TTF-I, , Molecular cell, 2010
DNA-Protein Interactions, , Methods in Molecular Biology™, 2009, 10.1007/978-1-60327-015-1
DNase I footprinting, , DNA-Protein Interactions, 2009
Loss of human ribosomal gene CpG methylation enhances cryptic RNA polymerase II transcription and disrupts ribosomal RNA processing, , Molecular cell, 2009
Mlk1, Nicolas Bisson, Thomas Moss, AfCS-Nature Molecule Pages, 2009, 10.1038/mp.a001549.01
Mlk2, Nicolas Bisson, Thomas Moss, AfCS-Nature Molecule Pages, 2009, 10.1038/mp.a001550.01
Role of p21-activated kinase in cell polarity and directional mesendoderm migration in the Xenopus gastrula, , Developmental dynamics, 2009
The cruciform DNA mobility shift assay: a tool to study proteins that recognize bent DNA, , DNA-Protein Interactions, 2009
A ubiquitin-conjugating enzyme, ube2d3. 2, regulates xMLK2 and pronephros formation in Xenopus, , Differentiation, 2008
Mice lacking both mixed-lineage kinase genes Mlk1 and Mlk2 retain a wild type phenotype, , Cell Cycle, 2008
The splice variants of UBF differentially regulate RNA polymerase I transcription elongation in response to ERK phosphorylation, , Nucleic acids research, 2008
UBF levels determine the number of active ribosomal RNA genes in mammals, , The Journal of cell biology, 2008
A housekeeper with power of attorney: the rRNA genes in ribosome biogenesis, , Cellular and molecular life sciences, 2007
EphA4 signaling regulates blastomere adhesion in the Xenopus embryo by recruiting Pak1 to suppress Cdc42 function, , Molecular biology of the cell, 2007
A new paradigm for the regulation of the mammalian ribosomal RNA genes., , Biochemical Society Transactions, 2006
ERK modulates DNA bending and enhancesome structure by phosphorylating HMG1-boxes 1 and 2 of the RNA polymerase I transcription factor UBF, , Biochemistry, 2006
Growth factor signaling regulates elongation of RNA polymerase I transcription in mammals via UBF phosphorylation and r-chromatin remodeling, , Molecular cell, 2006
Identification of a novel xPAK1 partner important for proper FGF signaling in Xenopus laevis, , Developmental Biology, 2006
Regulation of rRNA synthesis in human and mouse cells is not determined by changes in active gene count, , Cell Cycle, 2006
EphA4 signaling suppresses Cdc42 and RhoA activities by recruiting Pak1 in order to regulate blastomere association in the Xenopus blastula embryo., , DEVELOPMENTAL BIOLOGY, 2005
The RNA-binding protein fragile X-related 1 regulates somite formation in Xenopus laevis, , Molecular biology of the cell, 2005
At the crossroads of growth control; making ribosomal RNA, , Current opinion in genetics & development, 2004
A tissue restricted role for the Xenopus Jun N-terminal kinase kinase kinase MLK2 in cement gland and pronephric tubule differentiation, , Developmental biology, 2003
CELL GROWTH AND DEVELOPMENT-mTOR-Dependent Regulation of Ribosomal Gene Transcription Requires S6K1 and Is Mediated by Phosphorylation of the Carboxy-Terminal Activation Domain of the Nucleolar, , Molecular and Cellular Biology, 2003
mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF†, , Molecular and cellular biology, 2003
PAK interacts with NCK and MLK2 to regulate the activation of jun N-terminal kinase, , FEBS letters, 2003
The catalytic domain of xPAK1 is sufficient to induce myosin II dependent in vivo cell fragmentation independently of other apoptotic events, , Developmental biology, 2003
Gènes ribosomiques et régulation de la croissance cellulaire, Tom Moss, Nicolas Bissont, Emmanuel Käs, médecine/sciences, 2002, 10.1051/medsci/20021810940
At the Center of Eukaryotic Life, Tom Moss, Victor Y. Stefanovsky, Cell, 2002, 10.1016/s0092-8674(02)00761-4
DNA–Protein Interactions: Principles and Protocols, 2nd ed. Edited by Tom Moss, Leo Kretzner, Analytical Biochemistry, 2002, 10.1006/abio.2002.5609
An immediate response to ribosomal transcription to growth factor stimulation in mammals is mediated by ERK phosphorylation of UBF (vol 8, pg 1063, 2001), , MOLECULAR CELL, 2002
At the center of eukaryotic life, , Cell, 2002
Gènes ribosomiques et régulation de la croissance cellulaire, , Le Magazine: Nouvelles, 2002
THE MAGAZINE-NEWS-Ribosomal genes and cell growth, , Medecine Sciences, 2002
DNA-Protein Interactions. Principles and Protocols, second edition, edited by Tom Moss, Humana Press, 2001, 638 p., Olivier Leroy, Biochimie, 2001, 10.1016/s0300-9084(01)01337-2
DNA-Protein Interactions, Tom Moss, 2001, 10.1385/1592592082
An immediate response of ribosomal transcription to growth factor stimulation in mammals is mediated by ERK phosphorylation of UBF, , Molecular cell, 2001
DNA looping in the RNA polymerase I enhancesome is the result of non-cooperative in-phase bending by two UBF molecules, , Nucleic acids research, 2001
DNA-protein Interactions, , 2001
DNA-Protein Interactions: Principles and Protocols. Methods in Molecular Biology, , 2001
DNase I footprinting, , DNA-Protein Interactions, 2001
Competitive recruitment of CBP and Rb-HDAC regulates UBF acetylation and ribosomal transcription, , Molecular cell, 2000
The cytoskeletal effector xPAK1 is expressed during both ear and lateral line development in Xenopus, , INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 2000
The role of acetylation in rDNA transcription., , FASEB JOURNAL, 2000
A ribosomal orphon sequence from Xenopus laevis flanked by novel low copy number repetitive elements, , Biological chemistry, 1999
Cellular regulation of ribosomal DNA transcription: both rat and Xenopus UBF1 stimulate rDNA transcription in 3T3 fibroblasts, , Nucleic acids research, 1999
Identification of a mammalian RNA polymerase I holoenzyme containing components of the DNA repair/replication system, , Nucleic acids research, 1999
Affinity purification of mammalian RNA polymerase I Identification of an associated kinase, , Journal of Biological Chemistry, 1998
IS048 The a_1-Adrenergic Responsive Transcription Factor, UBF1, Regulates rDNA Transcription in Neonatal Cardiomyocytes, , Japanese circulation journal, 1998
The structural and architectural role of upstream binding factor, UBF, , Transcription of ribosomal genes by eukaryotic RNA polymerase I. Austin: Landes Bioscience, 1998
UV-Laser Crosslinking of Proteins to DNA, Tom Moss, Stefan I. Dimitrov, Daniel Houde, Methods, 1997, 10.1006/meth.1996.0409
UV-laser crosslinking of proteins to DNA, , Methods, 1997
Antisense and sense poly (A)- RNAs from the Xenopus laevis pyruvate dehydrogenase gene loci are regulated with message production during embryogenesis, , Gene, 1996
Catalytic and non-catalytic forms of the neurotrophin receptor xTrkB mRNA are expressed in a pseudo-segmental manner within the early Xenopus central nervous system., , The International journal of developmental biology, 1996
Enzymatic removal of vitelline membrane and other protocol modifications for whole mount in situ hybridization of Xenopus embryos, , Trends in Genetics, 1996
Inactivation of topoisomerase I or II may lead to recombination or to aberrant replication termination on both SV40 and yeast 2 $μ$m DNA, , Chromosoma, 1996
Overexpression of the transcription factor UBF1 is sufficient to increase ribosomal DNA transcription in neonatal cardiomyocytes: implications for cardiac hypertrophy, , Proceedings of the National Academy of Sciences, 1996
The DNA supercoiling architecture induced by the transcription factor xUBF requires three of its five HMG-boxes, , Nucleic acids research, 1996
Promotion and Regulation of Ribosomal Transcription in Eukaryotes by RNA Polymerase, Tom Moss, Victor Y. Stefanovsky, Progress in Nucleic Acid Research and Molecular Biology, 1995, 10.1016/s0079-6603(08)60810-7
Promotion and regulation of ribosomal transcription in eukaryotes by RNA polymerase 1, , Progress Nucl Acid Res Mol Biol, 1995
An analysis of Xenopus tyrosine kinase genes and their expression in early development, , DNA and cell biology, 1994
DNase I footprinting, , DNA-Protein Interactions, 1994
Short-range DNA looping by the Xenopus HMG-box transcription factor, xUBF, , Science, 1994
THE STRUCTURE OF THE XUBF-DNA COMPLEX, , JOURNAL OF CELLULAR BIOCHEMISTRY, 1994
Mapping of a sequence essential for the nuclear transport of the Xenopus ribosomal transcription factor xUBF using a simple coupled translation-transport and acid extraction approach, , DNA and cell biology, 1993
Recognition of the Xenopus ribosomal core promoter by the transcription factor xUBF involves multiple HMG box domains and leads to an xUBF interdomain interaction., , The EMBO journal, 1993
Readthrough enhancement and promoter occlusion on the ribosomal genes of Xenopus laevis, Tom Moss, Anne-Marie Larose, Keith Mitchelson, Benoît Leblanc, Biochemistry and Cell Biology, 1992, 10.1139/o92-050
High resolution studies of the Xenopus laevis ribosomal gene promoter in vivo and in vitro., , Journal of Biological Chemistry, 1992
Readthrough enhancement and promoter occlusion on the ribosomal genes of Xenopus laevis, , Biochemistry and Cell Biology, 1992
Variants of the Xenopus laevis ribosomal transcription factor xUBF are developmentally regulated by differential splicing, , Nucleic acids research, 1992
Heterogeneity in the Xenopus ribosomal transcription factor xUBF has a molecular basis distinct from that in mammals, , FEBS letters, 1991
The RNA polymerase I transcription factor xUBF contains 5 tandemly repeated HMG homology boxes, , Nucleic acids research, 1991
Point mutation analysis of the Xenopus laevis RNA polymerase I core promoter, , Nucleic acids research, 1990
Coordinate replication of dispersed repetitive sequences in Physarum polycephalum, , Experimental cell research, 1989
The Xenopus laevis ribosomal gene terminator contains sequences that both enhance and repress ribosomal transcription., , Molecular and cellular biology, 1989
DNA tailing without terminal transferase, Christine Dutta, Tom Moss, Nucleic Acids Research, 1988, 10.1093/nar/16.15.7744
A complex array of sequences enhances ribosomal transcription in Xenopus laevis, , Journal of molecular biology, 1987
The enhancement of ribosomal transcription by the recycling of RNA polymerase I, , Nucleic acids research, 1987
The enhancement of ribosomal transcription by the recycling of RNA polymerase I, Keith Mitchelson, Tom Moss, Nucleic Acids Research, 1987, 10.1093/nar/15.22.9577
Spacer promoters are essential for efficient enhancement of X. laevis ribosomal transcription, Ronald F.J. De Winter, Tom Moss, Cell, 1986, 10.1016/0092-8674(86)90765-8
Spacer promoters are essential for efficient enhancement of X. laevis ribosomal transcription, , Cell, 1986
The ribosomal spacer in Xenopus laevis is transcribed as part of the primary ribosomal RNA, , Nucleic acids research, 1986
The promotion of ribosomal transcription in eukaryotes., , Oxford surveys on eukaryotic genes, 1985
A transcriptional function for the repetitive ribosomal spacer in Xenopus laevis, Tom Moss, Nature, 1983, 10.1038/302223a0
A transcriptional function for repetitive ribosomal spacers in Xenopus?(reply), , Nature, 1983
A transcriptional function for the repetitive ribosomal spacer in Xenopus laevis, , Nature, 1983
The structure and function of the ribosomal gene spacer, , The nucleolus. Cambridge University Press, Cambridge, 1982
Transcription of cloned Xenopus laevis ribosomal DNA microinjected into Xenopus oocytes, and the identification of an RNA polymerase I promoter, , Cell, 1982
More ribosomal spacer sequences from Xenopus laevis, , Nucleic acids research, 1980
More ribosomal spacer sequences from Xenopus laevis, Tom Moss, Paul G. Boseley, Max L. Birnsteil, Nucleic Acids Research, 1980, 10.1093/nar/8.3.467
5'-Labeling and poly (dA) tailing., , Methods in enzymology, 1979
Sequence organization of the spacer DNA in a ribosomal gene unit of Xenopus laevis, , Cell, 1979
SEQUENCE-ANALYSIS SUGGESTS A POSSIBLE FUNCTION FOR THE RIBOSOMAL SPACER DNA OF XENOPUS-LAEVIS, , Experientia, 1979
The putative promoter of a Xenopus laevis ribosomal gene is reduplicated, , Nucleic acids research, 1979
The putative promoter of a Xenopus laevis ribosomal gene is reduplicated, Tom Moss, Max L. Birnstiel, Nucleic Acids Research, 1979, 10.1093/nar/6.12.3733
High-resolution proton-magnetic-resonance studies of chromatin core particles, , European Journal of Biochemistry, 1978
High-resolution proton-magnetic-resonance studies of chromatin core particles [calf thymus], , European Journal of Biochemistry (Germany, FR), 1978
METHOD TO FACILITATE BASE SEQUENCING OF HIGHLY REPETITIVE DNA, , EXPERIENTIA, 1978
Nucleosomes, histone interactions, and the role of histones H3 and H4, , Cold Spring Harbor symposia on quantitative biology, 1978
A nucleosome-like structure containing DNA and the arginine-rich histones H3 and H4, , Nucleic acids research, 1977
Sites of Histone/Histone Interaction in the H3˙ H4 Complex, , European Journal of Biochemistry, 1977
Physical studies on the H3/H4 histone tetramer, Tom Moss, Peter D. Cary, Colyn Crane-Robinson, E. M. Bradbury, Biochemistry, 1976, 10.1021/bi00656a003
A pH-Dependent Interaction between Histones H2A and H2B Involving Secondary and Tertiary Folding, , European Journal of Biochemistry, 1976
4. Fragile X Related 1 (xFxr1) de Xenopus laevis et la myogenèse primaire., , Résumé, 1911
DNase I Footprinting, Benoît Leblanc, Tom Moss, DNA-Protein Interactions, 1911, 10.1385/0-89603-256-6:1
DNase I Footprinting, Benoît Leblanc, Tom Moss, DNA-Protein Interactions, 1911, 10.1385/1-59259-208-2:031
DNase I Footprinting, Benoît Leblanc, Tom Moss, Nucleic Acid Protocols Handbook, The, 1911, 10.1385/1-59259-038-1:729
UV Laser-Induced Protein-DNA Crosslinking, Stefan I. Dimitrov, Tom Moss, DNA-Protein Interactions, 1911, 10.1385/1-59259-208-2:395
UV Laser-Induced Protein–DNA Crosslinking, Stefan I. Dimitrov, Tom Moss, DNA-Protein Interactions, 1911, 10.1385/0-89603-256-6:227
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Contribution à l'enseignement aux cycles supérieurs
Étudiant(e)s dirigé(e)s*
Depuis 2009
Jean-Clement Mars - Post-doctorat - En cours
Ines Bourafa - Doctorat - En cours
Mélissa Valère - Doctorat - En cours
Dany Sibai - Doctorat - En cours
Abdelatif Nourdine Hamdane - Doctorat - 2015/01
Joël Boutin - Maitrîse avec mémoire - 2015/05
Prakash Kumar Mishra - Doctorat - 2015/05
Chelsea Herdman - Maitrîse avec mémoire - 2015/05
Encadrement d'étudiant(e)s pour les programmes suivants :
*Les supervisions d’étudiant(e)s de 1er cycle en
stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées
ultérieurement.
Vice-décanat à la recherche et aux études supérieures Pavillon Ferdinand-Vandry Université Laval 1050, avenue de la Médecine, local 4645 Québec (Québec) G1V 0A6 Canada
Catherine Comtois Agente de gestion des études etudes.sup2@fmed.ulaval.ca Biostatistique Épidémiologie Évaluation économique des technologies de la santé Santé publique
Marianne Rivest et Claudia Gonzalez Agentes de gestion des études etudes.sup1@fmed.ulaval.ca Biologie cellulaire et moléculaire Génomique fonctionnelle Médecine moléculaire Microbiologie-immunologie Neurosciences
Isabelle Tremblay Agente de gestion des études etudes.sup3@fmed.ulaval.ca Pédagogie universitaire en sciences de la santé Sciences cliniques et biomédicales Sciences de la réadaptation Prévention et gestion de la santé et de la sécurité au travail