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Sylvain-Georges Bourgoin

Professeur titulaire

Sylvain-Georges Bourgoin
sylvain-georges.bourgoin@fmed.ulaval.ca
Centre de recherche du CHU de Québec - Université Laval
Centre de recherche en arthrite (ARThrite)
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Contribution à la recherche

Thématiques de recherche de la Faculté de médecine

  • Immunologie-infectiologie

Domaines de recherche

  • Immunité innée
  • Maladies auto-immunes
  • Signalisation intracellulaire, transduction des signaux, biologie des récepteurs et des membranes
  • Biologie des lipides (y compris la lipidomique)

Projets de recherche en cours

  • Metabolic mechanisms of pro-resolutive neutrophils in chronic inflammatory diseases - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2024-04-01 au 2029-03-31
  • Role of phosphatidylserine-specific phospholipase A1 (PLA1A) in the pathogenesis of rheumatic diseases - La société d'arthrite - Subvention stratégique de fonctionnement, chercheur principal - 2023-01-01 au 2025-12-31

Publications

  • Studies on the effects of disease-modifying antirheumatic drugs on lipoxygenase product synthesis in human neutrophils in vitro, Borgeat, P., Beaulieu, A.D., Marceau, F., Bourgoin, S., Poubelle, P.E., International Journal of Immunopharmacology, 1988, 10.1016/0192-0561(88)90024-0
  • The mechanism of docosahexaenoic acid-induced phospholipase D activation in human lymphocytes involves exclusion of the enzyme from lipid rafts, Prigent, A.-F., Némoz, G., Lagarde, M., Bourgoin, S., Sette, C., Agostino, D.S., Dubois, M., Berquand, A., Diaz, O., Journal of Biological Chemistry, 2002, 10.1074/jbc.M202376200
  • Low molecular weight GTP-binding proteins in HL-60 granulocytes. Assessment of the role of ARF and of a 50-kDa cytosolic protein in phospholipase D activation, Beaulieu, A., Takai, Y., Desmarais, Y., Harbour, D., Bourgoin, S., Journal of Biological Chemistry, 1995, 10.1074/jbc.270.7.3172
  • Targeting the autotaxin – Lysophosphatidic acid receptor axis in cardiovascular diseases, Sylvain G. Bourgoin, Chenqi Zhao, Stephan Hasse, Yang Zhao, Biochemical Pharmacology, 2019, 10.1016/j.bcp.2019.03.035
  • Red blood cell-derived phosphatidylserine positive extracellular vesicles are associated with past thrombotic events in patients with systemic erythematous lupus, Sylvain G Bourgoin, Paul R Fortin, Eric Boilard, Chenqi Zhao, Anne-Claire Duchez, Anne-Sophie Julien, Stephan Hasse, Lupus Science & Medicine, 2022, 10.1136/lupus-2021-000605
  • Cytohesin-1 regulates fMLF-mediated activation and functions of the β2integrin Mac-1 in human neutrophils, Bourgoin, S.G., Garceau, V., el Azreq, M.-A., Journal of Leukocyte Biology, 2011, 10.1189/jlb.0410222
  • Lipoxygenase and cyclooxygenase products of arachidonic acid in uterus. Selective interaction with the cGMP and cAMP systems, Harbon, S., Leiber, D., Bourgoin, S., Vesin, M.F., Prostaglandins, Leukotrienes and Medicine, 1984, 10.1016/0262-1746(84)90105-7
  • Effects of pyrrophenone, an inhibitor of group IVA phospholipase A2, on eicosanoid and PAF biosynthesis in human neutrophils, Borgeat, P., Bourgoin, S.G., Pouliot, M., Lemieux, L., Picard, S., Flamand, N., British Journal of Pharmacology, 2006, 10.1038/sj.bjp.0706879
  • Subcellular distribution and characterization of rat pancreatic phospholipase D isoforms, Morisset, J., Bourassa, J., Bourgoin, S., Lainé, J., Pancreas, 2000, 10.1097/00006676-200005000-00001
  • Involvement of a phospholipase D in the mechanism of action of granulocyte-macrophage colony-stimulating factor (GM-CSF): Priming of human neutrophils in vitro with GM-CSF Is associated with accumulation of phosphatidic acid and diradylglycerol, Poubelle, P.E., Borgeat, P., Naccache, P.H., Gaudry, M., Plante, E., Bourgoin, S., Journal of Experimental Medicine, 1990, 10.1084/jem.172.3.767
  • Phospholipase D2 is localized to the rims of the Golgi apparatus in mammalian cells, Shields, D., Bourgoin, S., Freyberg, Z., Molecular Biology of the Cell, 2002, 10.1091/mbc.02-04-0059
  • The PGE2-induced inhibition of the PLD activation pathway stimulated by fMLP in human neutrophils is mediated by PKA at the PI3-Kγ level, Bourgoin, S.G., Naccache, P.H., Harbour, D., Thibault, N., Burelout, C., Biochemical Pharmacology, 2007, 10.1016/j.bcp.2007.06.013
  • GLUT-4 translocation in skeletal muscle studied with a cell-free assay: Involvement of phospholipase D, Richter, E.A., Franco, M., Klip, A., Bourgoin, S., Nielsen, J.N., Kristiansen, S., American Journal of Physiology - Endocrinology and Metabolism, 2001
  • Intracellular localization of phospholipase D1 in mammalian cells, Shields, D., Frohman, M., Bourgoin, S., Siddhanta, A., Sweeney, D., Freyberg, Z., Molecular Biology of the Cell, 2001, 10.1091/mbc.12.4.943
  • Intra-endosomal pH-sensitive Recruitment of the Arf-nucleotide Exchange Factor ARNO and Arf6 from Cytoplasm to Proximal Tubule Endosomes, Marshansky, V., Ausiello, D.A., Vinay, P., Casanova, J.E., Bourgoin, S., Brown, D., Maranda, B., Journal of Biological Chemistry, 2001, 10.1074/jbc.M011577200
  • The role of serotonin and other neuroactive molecules in the physiopathogenesis of migraine: Current hypotheses,Implications de la serotonine et d'autres molecules neuroactives dans la physiopathogenie de la migraine. Hypotheses actuelles, Bourgoin, S., Hamon, M., Pathologie Biologie, 2000
  • Regulation of phospholipase D by phosphorylation-dependent mechanisms, Bourgoin, S., Houle, M.G., Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1999, 10.1016/S1388-1981(99)00090-6
  • Cytohesin binder and regulator augments T cell receptor-induced nuclear factor of activated T cells·AP-1 activation through regulation of the JNK pathway, Gadina, M., Bourgoin, S.G., Coffey, A., Chen, Q., Journal of Biological Chemistry, 2006, 10.1074/jbc.M601629200
  • Cholesterol-modulating agents selectively inhibit calcium influx induced by chemoattractants in human neutrophils, Naccache, P.H., Bourgoin, S.G., Fernandes, M.J.G., Paré, G., Barabé, F., Journal of Biological Chemistry, 2002, 10.1074/jbc.M112149200
  • TNF-α promotes LPA1- and LPA3-mediated recruitment of leukocytes in vivo through CXCR2 ligand chemokines, Bourgoin, S.G., Fernandes, M.J., Poubelle, P.E., Chun, J., Sardella, A., Zhao, C., Journal of Lipid Research, 2011, 10.1194/jlr.M008045
  • Phospholipase D in rat myometrium: Occurrence of a membrane-bound ARF6 (ADP-ribosylation factor 6)-regulated activity controlled by βγ subunits of heterotrimeric G-proteins, Harbon, S., Bader, M.-F., Bourgoin, S., Dokhac, L., Le Stunff, H., Biochemical Journal, 2000, 10.1042/0264-6021:3520491
  • Differential effects of inhibitor combinations on Lysophosphatidic acid-mediated chemokine secretion in unprimed and tumor necrosis Factor-α-primed synovial fibroblasts, Bourgoin, S.G., Zhao, C., Hui, W., Frontiers in Pharmacology, 2017, 10.3389/fphar.2017.00848
  • Human phospholipase D1 can be tyrosine-phosphorylated in HL-60 granulocytes, Bourgoin, S., Naccache, P.H., Harbour, D., Marcil, J., Journal of Biological Chemistry, 1997, 10.1074/jbc.272.33.20660
  • Dissociation between the translocation and the activation of Akt in fMLP-stimulated human neutrophils - Effect of prostaglandin E2, Bourgoin, S.G., Naccache, P.H., Burelout, C., Journal of Leukocyte Biology, 2007, 10.1189/jlb.0406256
  • Functional Role of AGAP2/PIKE-A in Fcγ Receptor-Mediated Phagocytosis, Sylvain G. Bourgoin, Caroline Gilbert, Lynn Davis, François C. Chouinard, Cells, 2022, 10.3390/cells12010072
  • Receptor-mediated endocytosis in kidney proximal tubules: Recent advances and hypothesis, Vinay, P., Maranda, B., Bendayan, M., Londoño, I., Bourgoin, S., Marshansky, V., Electrophoresis, 1997, 10.1002/elps.1150181423
  • Interplay between LPA2 and LPA3 in LPA-mediated phosphatidylserine cell surface exposure and extracellular vesicles release by erythrocytes, Sylvain G. Bourgoin, Eric Boilard, Paul Fortin, Anne-Claire Duchez, Stephan Hasse, Sylvain Bourgoin, Biochemical Pharmacology, 2021, 10.1016/j.bcp.2021.114667
  • Impairment of chemical hypoxia-induced sphingosine kinase-1 expression and activation in rheumatoid arthritis synovial fibroblasts: A signature of exhaustion?, Sylvain G. Bourgoin, Maria J. Fernandes, John A. Di Battista, David Marsolais, Melissa Laflamme, Nathalie Amiable, Chenqi Zhao, Biochemical Pharmacology, 2019, 10.1016/j.bcp.2019.02.009
  • LPA promotes T cell recruitment through synthesis of CXCL13, Bourgoin, S.G., Zhao, C., Hui, W., Mediators of Inflammation, 2015, 10.1155/2015/248492
  • ACAP1 promotes endocytic recycling by recognizing recycling sorting signals, Hsu, V.W., Peters, P.J., Bourgoin, S., Premont, R.T., Porcionatto, M., Bos, E., Li, J., Dai, J., Developmental Cell, 2004, 10.1016/j.devcel.2004.10.002
  • Interactions of SIN-1 with the generation of cyclic nucleotides and arachidonate metabolites in the uterine smooth muscle,INTERACTIONS DU SIN-1 AVEC LA GENERATION DES NUCLEOTIDES CYCLIQUES ET DES METABOLITES OXYDES DE L'ARACHIDONATE DANS LE MUSCLE UTERIN, Harbon, S., Leiber, D., Bourgoin, S., Pathologie Biologie, 1987
  • Priming of calcium mobilization in human neutrophils by granulocyte-macrophage colony-stimulating factor: Evidence for an involvement of phospholipase D-derived phosphatidic acid, Bourgoin, S., Gaudry, M., Hamelin, B., Naccache, P.H., Cellular Signalling, 1991, 10.1016/0898-6568(91)90040-2
  • Identification of an autoantigen on the surface of apoptotic human T cells as a new protein interacting with inflammatory group IIA phospholipase A 2, Surette, M.E., Bernatchez, C., Bourgoin, S.G., Boilard, E., Blood, 2003, 10.1182/blood-2002-12-3702
  • Identification of ADP-ribosylation factor-6 in brushborder membrane and early endosomes of human kidney proximal tubules, Vinay, P., Bendayan, M., Londoño, I., Bourgoin, S., Marshansky, V., Electrophoresis, 1997, 10.1002/elps.1150180334
  • Tyrosine kinase-regulated small GTPase translocation and the activation of phospholipase D in HL60 granulocytes, Bourgoin, S., Naccache, P.H., Houle, M.G., Journal of Leukocyte Biology, 1999, 10.1002/jlb.66.6.1021
  • Diverging signal transduction pathways activated by interleukin-8 and related chemokines in human neutrophils: Interleukin-8, but not NAP-2 or GROα, stimulates phospholipase D activity, Naccache, P.H., McColl, S.R., Jean, N., Bourgoin, S., L'Heureux, G.P., Blood, 1995
  • Prostaglandin G/H synthase (PGHS)-2 expression in bovine myometrium: Influence of steroid hormones and PGHS inhibitors, Fortier, M.A., Bourgoin, S., Guay, J.M., Doualla-Bell, F., Biology of Reproduction, 1998, 10.1095/biolreprod59.6.1433
  • Inhibition of platelet-activating factor biosynthesis by adenosine and histamine in human neutrophils: Involvement of cPLA2α and reversal by lyso-PAF, Borgeat, P., Bourgoin, S.G., Lemieux, L., Picard, S., Lapointe, G., Lefebvre, J., Flamand, N., Journal of Leukocyte Biology, 2006, 10.1189/jlb.1005614
  • Interaction of low molecular weight group IIA phospholipase A2 with apoptotic human T cells: Role of heparan sulfate proteoglycans, Surette, M.E., Poubelle, P.E., Bernatchez, C., Bourgoin, S.G., Boilard, E., FASEB Journal, 2003, 10.1096/fj.02-0938com
  • Cross-talk between CD14 and complement receptor 3 promotes phagocytosis of mycobacteria: Regulation by phosphatidylinositol 3-kinase and cytohesin-1, Hmama, Z., Talal, A., Bourgoin, S., Lee, J.S.I., Reiner, N.E., Sendide, K., Journal of Immunology, 2005, 10.4049/jimmunol.174.7.4210
  • Crystal-induced neutrophil activation. IX. Syk-dependent activation of class Ia phosphatidylinositol 3-kinase, Naccache, P.H., Bourgoin, S.G., Gilbert, C., Thibault, N., Rollet-Labelle, E., Popa-Nita, O., Journal of Leukocyte Biology, 2007, 10.1189/jlb.0307174
  • Prostaglandin E2inhibits the phospholipase D pathway stimulated by formyl-methionyl-leucyl-phenylalanine in human neutrophils. Involvement of EP2receptors and phosphatidylinositol 3-kinase γ, Bourgoin, S.G., Naccache, P.H., Simard, S., Levasseur, S., Thibault, N., Burelout, C., Molecular Pharmacology, 2004, 10.1124/mol.66.2.293
  • Regulation of lysophosphatidic acid receptor expression and function in human synoviocytes: Implications for rheumatoid arthritis?, Bourgoin, S.G., Poubelle, P.E., Clair, T., Di Battista, J., Turgeon, M., Prestwich, G.D., Fernandes, M.J., Zhao, C., Molecular Pharmacology, 2008, 10.1124/mol.107.038216
  • Chemotactic factor-induced recruitment and activation of Tec family kinases in human neutrophils. II. Effects of LFM-A13, a specific Btk inhibitor, Naccache, P.H., Bourgoin, S.G., Thibault, N., Dusseault, A.-A., Desaulniers, P., Levasseur, S., Gilbert, C., Journal of Immunology, 2003, 10.4049/jimmunol.170.10.5235
  • Granulocyte-macrophage colony-stimulating factor (GM-CSF) primes human neutrophils for enhanced phosphatidylcholine breakdown by phospholipase D, Poubelle, P.E., Borgeat, P., Bourgoin, S., Agents and Actions, 1991, 10.1007/BF01993230
  • Compartmentalization of the Mitogen-Activated Protein Kinase (MAPK) in hepatic endosomes: Association with the internalized Epidermal Growth Factor (EGF) receptor, Fortier, S., Bourgoin, S., Gaulin, J.-F., Faure, R., Molecular Cell Biology Research Communications, 1999, 10.1006/mcbr.1999.0120
  • Cyclic AMP-mediated inhibition of 5-lipoxygenase translocation and leukotriene biosynthesis in human neutrophils, Borgeat, P., Bourgoin, S., Picard, S., Surette, M.E., Flamand, N., Molecular Pharmacology, 2002, 10.1124/mol.62.2.250
  • Caspase cleavage of phospholipase D1 in vitro alters its regulation and reveals a novel property of the "loop" region, Shields, D., Bourgoin, S., Riebeling, C., Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 2008, 10.1016/j.bbalip.2008.05.007
  • Regulators and Effectors of Arf GTPases in Neutrophils, Bourgoin, S.G., Aoudjit, F., Davis, L., Chouinard, F., Gamara, J., Journal of Immunology Research, 2015, 10.1155/2015/235170
  • Monosodium urate-crystal-stimulated phospholipase D in human neutrophils, Bourgoin, S., Naccache, P.H., Houle, M.G., Harbour, D., Marcil, J., Biochemical Journal, 1999, 10.1042/0264-6021:3370185
  • Altered formation of leukotriene B4in vitro by synovial fluid neutrophils in rheumatoid arthritis, Borgeat, P., Beaulieu, A.D., Nguyen, M.-H., McColl, S.R., Bourgoin, S., Poubelle, P.E., Journal of Rheumatology, 1989
  • Phospholipases D1 and D2 coordinately regulate macrophage phagocytosis, Kusner, D.J., Bourgoin, S., Barton, J.A., Iyer, S.S., Journal of Immunology, 2004, 10.4049/jimmunol.173.4.2615
  • Interference of HIV-1 Nef in the sphingomyelin transduction pathway activated by tumour necrosis factor-α in human glial cells, Poulin, L., Darveau, A., Bourgoin, S., Lapointe, R., Robichaud, G., Richard, A., AIDS, 1997, 10.1097/00002030-199701000-00001
  • Phosphatidylserine-specific phospholipase A1: A friend or the devil in disguise, Sylvain G. Bourgoin, Stephan Hasse, Yang Zhao, Sylvain Bourgoin, Progress in Lipid Research, 2021, 10.1016/j.plipres.2021.101112
  • Metabolic regulation of neutrophil functions in homeostasis and diseases, Martin Pelletier, Philippe A Tessier, Patrice E Poubelle, Sylvain G Bourgoin, Pier-Olivier Leblanc, Journal of Leukocyte Biology, 2024, 10.1093/jleuko/qiae025
  • Activation of phospholipase D by bradykinin and sphingosine 1-phosphate in A549 human lung adenocarcinoma cells via different GTP-binding proteins and protein kinase C delta signaling pathways, Vaughan, M., Moss, J., Bruni, P., Bourgoin, S., Donati, C., Vasta, V., Catarzi, S., Nuti, F., Meacci, E., Biochemistry, 2003, 10.1021/bi026350a
  • Regulation of Constitutive Protein Transit by Phospholipase D in HT29-cl19A Cells, Raymond, M.-N., Frohman, M.A., Bourgoin, S., Min, D.S., Geny, B., Robin, P., Honkavaara, P., Phebidias, C., Denmat-Ouisse, L.-A., Journal of Biological Chemistry, 2001, 10.1074/jbc.M104276200
  • Granulocyte-macrophage colony-stimulating factor primes phospholipase D activity in human nerutrophils in vitro: Role of calcium, G-proteins and tyrosine kinases, Naccache, P.H., Borgeat, P., Emezawa, K., Liao, N.W., Poubelle, P.E., Bougoin, S., Cellular Signalling, 1992, 10.1016/0898-6568(92)90018-4
  • Differential expression and targeting of endogenous Arf1 and Arf6 small GTPases in kidney epithelial cells in situ, Marshansky, V., Ausiello, D.A., Bourgoin, S., Breton, S., Brown, D., El Annan, J., American Journal of Physiology - Cell Physiology, 2004
  • Tumor necrosis factor-α induces stress fiber formation through ceramide production: Role of sphingosine kinase, Brindley, D.N., Bourgoin, S., Begg, D., Kikuchi, Y., Berthiaume, L.G., Hanna, A.N., Molecular Biology of the Cell, 2001, 10.1091/mbc.12.11.3618
  • Evidence for a role for SAM68 in the responses of human neutrophils to ligation of CD32 and to monosodium urate crystals, Naccache, P.H., Damaj, B.B., McColl, S.R., Bourgoin, S.G., Rollet-Labelle, E., Barabé, F., Gilbert, C., Journal of Immunology, 2001, 10.4049/jimmunol.166.7.4664
  • Inhibition of tyrosine phosphorylation by Wortmannin in human neutrophils. Dissociation from its inhibitory effects on phospholipase D, Bourgoin, S., Poubelle, P.E., Roberge, C.J., Gaudry, M., Gilbert, C., Caon, A.C., Naccache, P.H., Laboratory Investigation, 1993
  • Characterisation of degranulation and phagocytic capacity of a human neutrophilic cellular model, PLB-985 cells, Bourgoin, S.G., Harbour, D., Amine El Azreq, M., Chouinard, F.C., Pivot-Pajot, C., Immunobiology, 2010, 10.1016/j.imbio.2009.01.007
  • Arf6 regulates energy metabolism in neutrophils, Sylvain Bourgoin, Martin Pelletier, Fawzi Aoudji, Yasunori Kanaho, Yuji Funakoshi, Tsunaki Hongu, Chenqi Zhao, Emmanuelle Rollet-Labelle, Nathalie Pagé, Andrew Z. Leong, Lynn Davis, Jouda Gamara, Free Radical Biology and Medicine, 2021, 10.1016/j.freeradbiomed.2021.07.001
  • Expression and activity of prostaglandin endoperoxide synthase-2 in agonist-activated human neutrophils, Naccache, P.H., McColl, S.R., Maclouf, J., Créminon, C., Bourgoin, S., Poubelle, P.E., Borgeat, P., Gilbert, C., Pouliot, M., FASEB Journal, 1998
  • ARFGAP1 promotes the formation of COPI vesicles, suggesting function as a component of the coat, Hsu, V.W., Premont, R.T., Randazzo, P.A., Bourgoin, S., Gao, M., Lee, S.Y., Yang, J.-S., Journal of Cell Biology, 2002, 10.1083/jcb.200206015
  • Agonist-specific tyrosine phosphorylation of Cbl in human neutrophils, Bourgoin, S.G., Mahana, W., Al-Shami, A., Barabé, F., Gilbert, C., Naccache, P.H., Journal of Leukocyte Biology, 1997, 10.1002/jlb.62.6.901
  • Granulocyte-macrophage colony-stimulating factor-activated signaling pathways in human neutrophils. I. Tyrosine phosphorylation-dependent stimulation of phosphatidylinositol 3-kinase and inhibition by phorbol esters, Naccache, P.H., Bourgoin, S.G., Al-Shami, A., Blood, 1997
  • Ras/mitogen-activated protein kinase mediates norepinephrine-induced phospholipase D activation in rabbit aortic smooth muscle cells by a phosphorylation-dependent mechanism, Malik, K.U., Bourgoin, S., Adl, M.Z., Khandekar, Z., Ahmed, A., Karzoun, N., Benter, I.F., Parmentier, J.-H., Muthalif, M.M., Journal of Pharmacology and Experimental Therapeutics, 2000
  • C2-ceramide primes specifically for the superoxide anion production induced by N-formylmethionylleucyl phenylalanine (fMLP) in human neutrophils, Pelletier, G., McColl, S.R., Krump, E., L'Heureux, G.P., Naccache, P.H., Bourgoin, S., Richard, A., Biochimica et Biophysica Acta - Lipids and Lipid Metabolism, 1996, 10.1016/0005-2760(95)00215-4
  • Granulocyte-macrophage colony-stimulating factor (GM-CSF) and opsonization synergistically enhance leukotriene B4(LTB4) synthesis induced by phagocytosis in human neutrophils, Borgeat, P., Naccache, P.H., Bourgoin, S., Poubelle, P.E., Agents and Actions, 1989, 10.1007/BF01972830
  • Role of protein kinase Cα, Arf, and cytoplasmic calcium transients in phospholipase D activation by sodium fluoride in osteoblast-like cells, Poubelle, P.E., Harbour, D., Bourgoin, S.G., Journal of Bone and Mineral Research, 1996
  • Differential expression of adenosine receptors in human neutrophils: Up-regulation by specific Th1 cytokines and lipopolysaccharide, Bourgoin, S., Borgeat, P., Fernandes, M., Harbour, D., Fortin, A., Journal of Leukocyte Biology, 2006, 10.1189/jlb.0505249
  • Arachidonic acid activates phospholipase D in human neutrophils; essential role of endogenous leukotriene B4and inhibition by adenosine A2Areceptor engagement, Bourgoin, S.G., Borgeat, P., Naccache, P.H., Pelletier, J., Flamand, N., Grenier, S., Journal of Leukocyte Biology, 2003, 10.1189/jlb.0702371
  • A phosphorylatable sphingosine analog induces airway smooth muscle cytostasis and reverses airway hyperresponsiveness in experimental asthma, Marsolais, D., Bossé, Y., Bourgoin, S.G., Laplante, M., Blanchet, M.-R., Bissonnette, É., Don, A.S., Flamand, N., Lee-Gosselin, A., Huppé, C.-A., Beaulieu, M.-J., Lemay, A.-M., Lecours, P.B., Gendron, D.R., Frontiers in Pharmacology, 2017, 10.3389/fphar.2017.00078
  • Human Inflammatory Neutrophils Express Genes Encoding Peptidase Inhibitors: Production of Elafin Mediated by NF-κB and CCAAT/Enhancer-Binding Protein β, Patrice E Poubelle, Sylvain G Bourgoin, Flavia Ribeiro de Vargas, Isabelle Allaeys, The Journal of Immunology, 2021, 10.4049/jimmunol.2000852
  • Peroxides of vanadate induce activation of phospholipase D in HL-60 cells: Role of tyrosine phosphorylation, Grinstein, S., Bourgoin, S., Journal of Biological Chemistry, 1992
  • Phospholipase A1 Member A Activates Fibroblast-like Synoviocytes through the Autotaxin-Lysophosphatidic Acid Receptor Axis, Sylvain G. Bourgoin, Patrice E. Poubelle, John Di Battista, Paul Fortin, Eric Boilard, Lynn Davis, Chenqi Zhao, Myriam Vaillancourt, Stephan Hasse, Yang Zhao, Sylvain Bourgoin, International Journal of Molecular Sciences, 2021, 10.3390/ijms222312685
  • Ceramide inhibition of mammalian phospholipase D1 and D2 activities is antagonized by phosphatidylinositol 4,5-bisphosphate, Brindley, D.N., Morris, A.J., Sciorra, V.A., Bourgoin, S.G., Stromberg, L.M., Singh, I.N., Biochemistry, 2001, 10.1021/bi010787l
  • ARNO but not cytohesin-1 translocation is phosphatidylinositol 3-kinase-dependent in HL-60 cells, Brindley, D.N., Morris, A.J., Gagnon, S., Harbour, D., Singh, I.N., Houle, M.G., Bourgoin, S.G., Journal of Leukocyte Biology, 2002
  • A transgenic mouse model for the in vivo bioluminescence imaging of the expression of the lysophosphatidic acid receptor 3: relevance for inflammation and uterine physiology research, Maria J. Fernandes, Sylvain G. Bourgoin, Patrice E. Poubelle, Lynn Davis, Anne Sardella, Chenqi Zhao, Sylvain Bourgoin, Transgenic Research, 2015, 10.1007/s11248-015-9882-8
  • ADP-ribosylation factor translocation correlates with potentiation of GTPγS-stimulated phospholipase D activity in membrane fractions of HL-60 cells, Bourgoin, S., Naccache, P.H., Kahn, R.A., Houle, M.G., Journal of Biological Chemistry, 1995, 10.1074/jbc.270.39.22795
  • Expression and distribution of adenosine diphosphate-ribosylation factors in the rat kidney, Bendayan, M., Vinay, P., Bourgoin, S., Marshansky, V., Londono, I., Kidney International, 1999, 10.1046/j.1523-1755.1999.00365.x
  • V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway, Marshansky, V., Brown, D., Ausiello, D.A., Bechoua, S., Wildeman, A., Casanova, J., Bourgoin, S., Sun-Wada, G.-H., Futai, M., El Annan, J., Skinner, M., Hurtado-Lorenzo, A., Nature Cell Biology, 2006, 10.1038/ncb1348
  • Stimulation of human neutrophils by chemotactic factors is associated with the activation of phosphatidylinositol 3-kinase γ, McColl, S.R., Bourgoini, S.G., Chakravarti, S., Lachance, G., Levasseur, S., Naccache, P.H., Journal of Biological Chemistry, 2000, 10.1074/jbc.M001780200
  • Phospholipase D2 in prostate cancer: protein expression changes with Gleason score, Martin G. Rumsby, Norman J. Maitland, Sylvain Bourgoin, Daniel M. Berney, Rakesh Suman, Karen Hogg, Amanda R. Noble, Sylvain Bourgoin, British Journal of Cancer, 2019, 10.1038/s41416-019-0610-7
  • Protein kinase Cζ regulates phospholipase D activity in rat-1 fibroblasts expressing the α1A adrenergic receptor, Malik, K.U., Bourgoin, S.G., Saeed, A.E., Wiggins, M.T., Gandhi, G.K., Parmentier, J.-H., BMC Cell Biology, 2004, 10.1186/1471-2121-5-4
  • Cytohesin-1 regulates human blood neutrophil adhesion to endothelial cells through β2 integrin activation, Bourgoin, S.G., El azreq, M.-A., Molecular Immunology, 2011, 10.1016/j.molimm.2011.03.018
  • Small GTPase-regulated phospholipase D in granulocytes, Bourgoin, S., Houle, M.G., Biochemistry and Cell Biology, 1996, 10.1139/o96-050
  • Crystal-induced neutrophil activation. VII. Involvement of Syk in the responses to monosodium urate crystals, Naccache, P.H., Bourgoin, S.G., Gilbert, C., Fernandes, M., Desaulniers, P., Journal of Leukocyte Biology, 2001
  • Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules, Eric Boilard, Benoît Vingert, Mélanie Dieudé, Bogdan Iulius Florea, Herman S. Overkleeft, France Pirenne, Marie-Josée Hébert, John Semple, Rick Kapur, Fabrice Cognasse, HAMZEH-COGNASSE, Sylvain Bourgoin, Julie Turgeon, Annie Karakeussian Rimbaud, Johan Rebetz, Tania Lévesque, Anne Zufferey, Isabelle Allaeys, Marie Tamagne, Maroua Mbarik, Stephan Hasse, Marie Bellio, Audrée Laroche, Genevieve Marcoux, Blood, 2021, 10.1182/blood.2020009957
  • Chemical Hypoxia Brings to Light Altered Autocrine Sphingosine-1-Phosphate Signalling in Rheumatoid Arthritis Synovial Fibroblasts, Bourgoin, S.G., Touaibia, M., Fernandes, M.J., Di Battista, J.A., Moreno-Nieves, U., Zhao, C., Mediators of Inflammation, 2015, 10.1155/2015/436525
  • An essential role for phospholipase D in the recruitment of vesicle amine transport protein-1 to membranes in human neutrophils, Bourgoin, S.G., El azreq, M.-A., Harbour, D., Chouinard, F.C., Faugaret, D., Biochemical Pharmacology, 2011, 10.1016/j.bcp.2010.09.014
  • The characterization of phospholipase D in FRTL-5 thyroid cells, Ginsberg, J., Brindley, D.N., Bourgoin, S., Singh, I., Das, S., Devlin, M.A., Molecular and Cellular Endocrinology, 2000, 10.1016/S0303-7207(00)00299-9
  • Specific and overlapping sphingosine-1-phosphate receptor functions in human synoviocytes: Impact of TNF-α, Bourgoin, S.G., Poubelle, P.E., Di Battista, J., Tancrède, S., Turgeon, M., Fernandes, M.J., Zhao, C., Journal of Lipid Research, 2008, 10.1194/jlr.M800143-JLR200
  • Characterization of cytohesin-1 monoclonal antibodies: Expression in neutrophils and during granulocytic maturation of HL-60 cells, Bourgoin, S.G., Naccache, P.H., Harbour, D., Gagnon, S., Chouinard, F., Houle, M.G., Garceau, V., Journal of Immunological Methods, 2001, 10.1016/S0022-1759(00)00336-7
  • Automated on-line extraction and profiling of lipoxygenase products of arachidonic acid by high-performance liquid chromatography, Epoubelle, P., Sirois, P., Odeimat, A., Bourgoin, S., Vallerand, P., Picard, S., Borgeat, P., Methods in Enzymology, 1990, 10.1016/0076-6879(90)87014-T
  • Adenosine receptor occupancy suppresses chemoattractant-induced phospholipase D activity by diminishing membrane recruitment of small GTPases, Bourgoin, S.G., Naccache, P.H., Borgeat, P., Harbour, D., Thibault, N., Blood, 2000
  • Crystal‐induced neutrophil activation. II. evidence for the activation of a phosphatidylcholine‐specific phospholipase D, Poubelle, P.E., Lussier, A., De Medicis, R., Roberge, C.J., Plante, E., Bourgoin, S., Naccache, P.H., Arthritis & Rheumatism, 1993, 10.1002/art.1780360119
  • Crystal-induced neutrophil activation VI. Involvement of FcγRIIIB (CD16) and CD11b in response to inflammatory microcrystals, Naccache, P.H., Bourgoin, S.G., Liao, N., Gilbert, C., Barabé, F., FASEB Journal, 1998
  • A role for phosphatidic acid in COPI vesicle fission yields insights into Golgi maintenance, Hsu, V.W., Luini, A., Frohman, M.A., Bourgoin, S., Graziani, A., Baldanzi, G., Du, G., Bonsra, A.N., Turacchio, G., Valente, C., Beznoussenko, G.V., Zhang, L., Mironov, A., Lee, S.Y., Gad, H., Yang, J.-S., Nature Cell Biology, 2008, 10.1038/ncb1774
  • Isolation of heavy endosomes from dog proximal tubules in suspension, Vinay, P., Bourgoin, S., Noël, J., Fleser, A., Marshansky, V., Journal of Membrane Biology, 1996, 10.1007/s002329900110
  • EFA6, Exchange Factor for ARF6, Regulates the Actin Cytoskeleton and Associated Tight Junction in Response to E-Cadherin Engagement, Chardin, P., Franco, M., Bourgoin, S., Le Bivic, A., Chauvin, J.-P., Klein, S., Luton, F., Molecular Biology of the Cell, 2004, 10.1091/mbc.E03-10-0751
  • Munc13-4 regulates granule secretion in human neutrophils, Bourgoin, S.G., De Saint Basile, G., Varoqueaux, F., Pivot-Pajot, C., Journal of Immunology, 2008, 10.4049/jimmunol.180.10.6786
  • Cytohesin-1 regulates the Arf6-phospholipase D signaling axis in human neutrophils: Impact on superoxide anion production and secretion, Bourgoin, S.G., Pivot-Pajot, C., Harbour, D., Garceau, V., El Azreq, M.-A., Journal of Immunology, 2010, 10.4049/jimmunol.0901654
  • Occupancy of adenosine A2a receptors promotes fMLP-induced cyclic AMP accumulation in human neutrophils: Impact on phospholipase D activity and recruitment of small GTPases to membranes, Bourgoin, S.G., Naccache, P.H., Borgeat, P., Harbour, D., Burelout, C., Thibault, N., Journal of Leukocyte Biology, 2002
  • Lysophosphatidic acid-induced IL-8 secretion involves MSK1 and MSK2 mediated activation of CREB1 in human fibroblast-like synoviocytes, Bourgoin, S.G., Poubelle, P.E., Fernandes, M.J., Hui, W., Zhao, C., Biochemical Pharmacology, 2014, 10.1016/j.bcp.2014.04.012
  • Suppressive effects of adenosine on the 5-lipoxygenase pathway in human polymorphonuclear leukocytes, Borgeat, P., Bourgoin, S., Krump, E., Surette, M.E., Austin, M., Picard, S., Plante, H., Flamand, N., Drug Development Research, 2001, 10.1002/ddr.1140
  • Phospholipase A1 Member A Deficiency Alleviates Mannan-Induced Psoriatic Arthritis in Mice Model, Sylvain G. Bourgoin, Fawzi Aoudjit, Yang Zhao, International Journal of Molecular Sciences, 2022, 10.3390/ijms23158559
  • Effect of molsidomine derivative (SIN-1) on leukotriene synthesis in human leukocytes,EFFET DU SIN-1 SUR LA SYNTHESE DE LEUCOTRIENES DANS LES POLYMORPHONUCLEAIRES HUMAINS, Borgeat, P., Poubelle, P., Bourgoin, S., Pathologie Biologie, 1987
  • Autotaxin and lysophospholipids in rheumatoid arthritis, Zhao, C., Bourgoin, S.G., Current Opinion in Investigational Drugs, 2010
  • Assessment of Arf6 Deletion in PLB-985 Differentiated in Neutrophil-Like Cells and in Mouse Neutrophils: Impact on Adhesion and Migration, Sylvain G. Bourgoin, Fawzi Aoudjit, Yasunori Kanaho, Yuji Funakoshi, Tsunaki Hongu, Emmanuelle Rollet-Labelle, Lynn Davis, Jouda Gamara, Mediators of Inflammation, 2020, 10.1155/2020/2713074

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2020/05
  • Kenza Azoudj - Maîtrise avec mémoire - En cours
  • Marouane Bouabane - Maîtrise avec mémoire - En cours
  • Helyasadat Mortazavi - Post-doctorat - En cours
  • Jules Gignac - Maîtrise avec mémoire - En cours
  • Jouda Gamara - Doctorat - 2020/05
  • Lisa Auclert - Maîtrise avec mémoire - 2020/09
  • Stephan Hasse - Doctorat - 2021/09
  • Yang Zhao - Doctorat - 2022/05

Encadrement d'étudiant(e)s

Direction de recherche dans les domaines suivants :

  • Biologie cellulaire et moléculaire
  • Microbiologie-immunologie

En savoir plus sur les programmes

*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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