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Sylvain-Georges Bourgoin

Professeur titulaire

Sylvain-Georges Bourgoin
sylvain-georges.bourgoin@fmed.ulaval.ca
Centre de recherche du CHU de Québec - Université Laval
Centre de recherche en arthrite (ARThrite)
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Immunologie-infectiologie

Domaines et intérêts de recherche du (de la) professeur(e) :

Maladies infectieuses et immunitaires
  • Leucocytes
  • Maladies auto-immunes
  • Médiateurs immunologiques : cytokines et chimiokines
Appareil locomoteur et arthrite
  • Arthrite/arthrose

Projets de recherche

  • Role of phosphatidylserine-specific phospholipase A1 (PLA1A) in the pathogenesis of rheumatic diseases - La société d'arthrite - Subvention stratégique de fonctionnement, chercheur principal - 2023-01-01 au 2025-12-31
  • Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
  • Role of lyso-phosphatidylserine generated by phosphatidylserine-specific phospholipase A1 (PLA1A) in the pathogenesis of rheumatic diseases - CHU de Québec – Université Laval – CHUL - Aide à la recherche, chercheur principal - 2021-11-01 au 2022-10-31

Publications

  • Agonist-specific tyrosine phosphorylation of Cbl in human neutrophils, Bourgoin, S.G., Mahana, W., Al-Shami, A., Barabé, F., Gilbert, C., Naccache, P.H., Journal of Leukocyte Biology, 1997, 10.1002/jlb.62.6.901
  • Identification of ADP-ribosylation factor-6 in brushborder membrane and early endosomes of human kidney proximal tubules, Vinay, P., Bendayan, M., Londoño, I., Bourgoin, S., Marshansky, V., Electrophoresis, 1997, 10.1002/elps.1150180334
  • Small GTPase-regulated phospholipase D in granulocytes, Bourgoin, S., Houle, M.G., Biochemistry and Cell Biology, 1996, 10.1139/o96-050
  • ADP-ribosylation factor translocation correlates with potentiation of GTPγS-stimulated phospholipase D activity in membrane fractions of HL-60 cells, Bourgoin, S., Naccache, P.H., Kahn, R.A., Houle, M.G., Journal of Biological Chemistry, 1995, 10.1074/jbc.270.39.22795
  • Granulocyte-macrophage colony-stimulating factor (GM-CSF) primes human neutrophils for enhanced phosphatidylcholine breakdown by phospholipase D, Poubelle, P.E., Borgeat, P., Bourgoin, S., Agents and Actions, 1991, 10.1007/BF01993230
  • Automated on-line extraction and profiling of lipoxygenase products of arachidonic acid by high-performance liquid chromatography, Epoubelle, P., Sirois, P., Odeimat, A., Bourgoin, S., Vallerand, P., Picard, S., Borgeat, P., Methods in Enzymology, 1990, 10.1016/0076-6879(90)87014-T
  • Granulocyte-macrophage colony-stimulating factor (GM-CSF) and opsonization synergistically enhance leukotriene B4(LTB4) synthesis induced by phagocytosis in human neutrophils, Borgeat, P., Naccache, P.H., Bourgoin, S., Poubelle, P.E., Agents and Actions, 1989, 10.1007/BF01972830
  • Studies on the effects of disease-modifying antirheumatic drugs on lipoxygenase product synthesis in human neutrophils in vitro, Borgeat, P., Beaulieu, A.D., Marceau, F., Bourgoin, S., Poubelle, P.E., International Journal of Immunopharmacology, 1988, 10.1016/0192-0561(88)90024-0
  • Expression and activity of prostaglandin endoperoxide synthase-2 in agonist-activated human neutrophils, Naccache, P.H., McColl, S.R., Maclouf, J., Créminon, C., Bourgoin, S., Poubelle, P.E., Borgeat, P., Gilbert, C., Pouliot, M., FASEB Journal, 1998
  • Prostaglandin G/H synthase (PGHS)-2 expression in bovine myometrium: Influence of steroid hormones and PGHS inhibitors, Fortier, M.A., Bourgoin, S., Guay, J.M., Doualla-Bell, F., Biology of Reproduction, 1998, 10.1095/biolreprod59.6.1433
  • Prostaglandin G/H synthase (PGHS)-2 expression in bovine myometrium: Influence of steroid hormones and PGHS inhibitors, Fortier, M.A., Bourgoin, S., Guay, J.M., Doualla-Bell, F., Biology of Reproduction, 1998, 10.1095/biolreprod59.6.1433
  • Agonist-specific tyrosine phosphorylation of Cbl in human neutrophils, Bourgoin, S.G., Mahana, W., Al-Shami, A., Barabé, F., Gilbert, C., Naccache, P.H., Journal of Leukocyte Biology, 1997, 10.1002/jlb.62.6.901
  • Identification of ADP-ribosylation factor-6 in brushborder membrane and early endosomes of human kidney proximal tubules, Vinay, P., Bendayan, M., Londoño, I., Bourgoin, S., Marshansky, V., Electrophoresis, 1997, 10.1002/elps.1150180334
  • Crystal-induced neutrophil activation VI. Involvement of FcγRIIIB (CD16) and CD11b in response to inflammatory microcrystals, Naccache, P.H., Bourgoin, S.G., Liao, N., Gilbert, C., Barabé, F., FASEB Journal, 1998
  • Expression and distribution of adenosine diphosphate-ribosylation factors in the rat kidney, Bendayan, M., Vinay, P., Bourgoin, S., Marshansky, V., Londono, I., Kidney International, 1999, 10.1046/j.1523-1755.1999.00365.x
  • The characterization of phospholipase D in FRTL-5 thyroid cells, Ginsberg, J., Brindley, D.N., Bourgoin, S., Singh, I., Das, S., Devlin, M.A., Molecular and Cellular Endocrinology, 2000, 10.1016/S0303-7207(00)00299-9
  • Phospholipase D in rat myometrium: Occurrence of a membrane-bound ARF6 (ADP-ribosylation factor 6)-regulated activity controlled by βγ subunits of heterotrimeric G-proteins, Harbon, S., Bader, M.-F., Bourgoin, S., Dokhac, L., Le Stunff, H., Biochemical Journal, 2000, 10.1042/0264-6021:3520491
  • Tumor necrosis factor-α induces stress fiber formation through ceramide production: Role of sphingosine kinase, Brindley, D.N., Bourgoin, S., Begg, D., Kikuchi, Y., Berthiaume, L.G., Hanna, A.N., Molecular Biology of the Cell, 2001, 10.1091/mbc.12.11.3618
  • Occupancy of adenosine A2a receptors promotes fMLP-induced cyclic AMP accumulation in human neutrophils: Impact on phospholipase D activity and recruitment of small GTPases to membranes, Bourgoin, S.G., Naccache, P.H., Borgeat, P., Harbour, D., Burelout, C., Thibault, N., Journal of Leukocyte Biology, 2002
  • Cyclic AMP-mediated inhibition of 5-lipoxygenase translocation and leukotriene biosynthesis in human neutrophils, Borgeat, P., Bourgoin, S., Picard, S., Surette, M.E., Flamand, N., Molecular Pharmacology, 2002, 10.1124/mol.62.2.250
  • ARNO but not cytohesin-1 translocation is phosphatidylinositol 3-kinase-dependent in HL-60 cells, Brindley, D.N., Morris, A.J., Gagnon, S., Harbour, D., Singh, I.N., Houle, M.G., Bourgoin, S.G., Journal of Leukocyte Biology, 2002
  • Protein kinase Cζ regulates phospholipase D activity in rat-1 fibroblasts expressing the α1A adrenergic receptor, Malik, K.U., Bourgoin, S.G., Saeed, A.E., Wiggins, M.T., Gandhi, G.K., Parmentier, J.-H., BMC Cell Biology, 2004, 10.1186/1471-2121-5-4
  • Chemotactic factor-induced recruitment and activation of Tec family kinases in human neutrophils. II. Effects of LFM-A13, a specific Btk inhibitor, Naccache, P.H., Bourgoin, S.G., Thibault, N., Dusseault, A.-A., Desaulniers, P., Levasseur, S., Gilbert, C., Journal of Immunology, 2003, 10.4049/jimmunol.170.10.5235
  • Prostaglandin E2inhibits the phospholipase D pathway stimulated by formyl-methionyl-leucyl-phenylalanine in human neutrophils. Involvement of EP2receptors and phosphatidylinositol 3-kinase γ, Bourgoin, S.G., Naccache, P.H., Simard, S., Levasseur, S., Thibault, N., Burelout, C., Molecular Pharmacology, 2004, 10.1124/mol.66.2.293
  • EFA6, Exchange Factor for ARF6, Regulates the Actin Cytoskeleton and Associated Tight Junction in Response to E-Cadherin Engagement, Chardin, P., Franco, M., Bourgoin, S., Le Bivic, A., Chauvin, J.-P., Klein, S., Luton, F., Molecular Biology of the Cell, 2004, 10.1091/mbc.E03-10-0751
  • Phospholipases D1 and D2 coordinately regulate macrophage phagocytosis, Kusner, D.J., Bourgoin, S., Barton, J.A., Iyer, S.S., Journal of Immunology, 2004, 10.4049/jimmunol.173.4.2615
  • Differential expression of adenosine receptors in human neutrophils: Up-regulation by specific Th1 cytokines and lipopolysaccharide, Bourgoin, S., Borgeat, P., Fernandes, M., Harbour, D., Fortin, A., Journal of Leukocyte Biology, 2006, 10.1189/jlb.0505249
  • Effects of pyrrophenone, an inhibitor of group IVA phospholipase A2, on eicosanoid and PAF biosynthesis in human neutrophils, Borgeat, P., Bourgoin, S.G., Pouliot, M., Lemieux, L., Picard, S., Flamand, N., British Journal of Pharmacology, 2006, 10.1038/sj.bjp.0706879
  • Cytohesin-1 regulates the Arf6-phospholipase D signaling axis in human neutrophils: Impact on superoxide anion production and secretion, Bourgoin, S.G., Pivot-Pajot, C., Harbour, D., Garceau, V., El Azreq, M.-A., Journal of Immunology, 2010, 10.4049/jimmunol.0901654
  • TNF-α promotes LPA1- and LPA3-mediated recruitment of leukocytes in vivo through CXCR2 ligand chemokines, Bourgoin, S.G., Fernandes, M.J., Poubelle, P.E., Chun, J., Sardella, A., Zhao, C., Journal of Lipid Research, 2011, 10.1194/jlr.M008045
  • Cytohesin-1 regulates human blood neutrophil adhesion to endothelial cells through β2 integrin activation, Bourgoin, S.G., El azreq, M.-A., Molecular Immunology, 2011, 10.1016/j.molimm.2011.03.018
  • Cytohesin-1 regulates fMLF-mediated activation and functions of the β2integrin Mac-1 in human neutrophils, Bourgoin, S.G., Garceau, V., el Azreq, M.-A., Journal of Leukocyte Biology, 2011, 10.1189/jlb.0410222
  • Phospholipase A1 Member A Deficiency Alleviates Mannan-Induced Psoriatic Arthritis in Mice Model, Sylvain G. Bourgoin, Fawzi Aoudjit, Yang Zhao, International Journal of Molecular Sciences, 2022, 10.3390/ijms23158559
  • Studies on the effects of disease-modifying antirheumatic drugs on lipoxygenase product synthesis in human neutrophils in vitro, Borgeat, P., Beaulieu, A.D., Marceau, F., Bourgoin, S., Poubelle, P.E., International Journal of Immunopharmacology, 1988, 10.1016/0192-0561(88)90024-0
  • Small GTPase-regulated phospholipase D in granulocytes, Bourgoin, S., Houle, M.G., Biochemistry and Cell Biology, 1996, 10.1139/o96-050
  • ADP-ribosylation factor translocation correlates with potentiation of GTPγS-stimulated phospholipase D activity in membrane fractions of HL-60 cells, Bourgoin, S., Naccache, P.H., Kahn, R.A., Houle, M.G., Journal of Biological Chemistry, 1995, 10.1074/jbc.270.39.22795
  • Granulocyte-macrophage colony-stimulating factor (GM-CSF) primes human neutrophils for enhanced phosphatidylcholine breakdown by phospholipase D, Poubelle, P.E., Borgeat, P., Bourgoin, S., Agents and Actions, 1991, 10.1007/BF01993230
  • Automated on-line extraction and profiling of lipoxygenase products of arachidonic acid by high-performance liquid chromatography, Epoubelle, P., Sirois, P., Odeimat, A., Bourgoin, S., Vallerand, P., Picard, S., Borgeat, P., Methods in Enzymology, 1990, 10.1016/0076-6879(90)87014-T
  • Granulocyte-macrophage colony-stimulating factor (GM-CSF) and opsonization synergistically enhance leukotriene B4(LTB4) synthesis induced by phagocytosis in human neutrophils, Borgeat, P., Naccache, P.H., Bourgoin, S., Poubelle, P.E., Agents and Actions, 1989, 10.1007/BF01972830
  • Chemotactic factor-induced recruitment and activation of Tec family kinases in human neutrophils. II. Effects of LFM-A13, a specific Btk inhibitor, Naccache, P.H., Bourgoin, S.G., Thibault, N., Dusseault, A.-A., Desaulniers, P., Levasseur, S., Gilbert, C., Journal of Immunology, 2003, 10.4049/jimmunol.170.10.5235
  • ARNO but not cytohesin-1 translocation is phosphatidylinositol 3-kinase-dependent in HL-60 cells, Brindley, D.N., Morris, A.J., Gagnon, S., Harbour, D., Singh, I.N., Houle, M.G., Bourgoin, S.G., Journal of Leukocyte Biology, 2002
  • Cyclic AMP-mediated inhibition of 5-lipoxygenase translocation and leukotriene biosynthesis in human neutrophils, Borgeat, P., Bourgoin, S., Picard, S., Surette, M.E., Flamand, N., Molecular Pharmacology, 2002, 10.1124/mol.62.2.250
  • Occupancy of adenosine A2a receptors promotes fMLP-induced cyclic AMP accumulation in human neutrophils: Impact on phospholipase D activity and recruitment of small GTPases to membranes, Bourgoin, S.G., Naccache, P.H., Borgeat, P., Harbour, D., Burelout, C., Thibault, N., Journal of Leukocyte Biology, 2002
  • Tumor necrosis factor-α induces stress fiber formation through ceramide production: Role of sphingosine kinase, Brindley, D.N., Bourgoin, S., Begg, D., Kikuchi, Y., Berthiaume, L.G., Hanna, A.N., Molecular Biology of the Cell, 2001, 10.1091/mbc.12.11.3618
  • Phospholipase D in rat myometrium: Occurrence of a membrane-bound ARF6 (ADP-ribosylation factor 6)-regulated activity controlled by βγ subunits of heterotrimeric G-proteins, Harbon, S., Bader, M.-F., Bourgoin, S., Dokhac, L., Le Stunff, H., Biochemical Journal, 2000, 10.1042/0264-6021:3520491
  • The characterization of phospholipase D in FRTL-5 thyroid cells, Ginsberg, J., Brindley, D.N., Bourgoin, S., Singh, I., Das, S., Devlin, M.A., Molecular and Cellular Endocrinology, 2000, 10.1016/S0303-7207(00)00299-9
  • Expression and distribution of adenosine diphosphate-ribosylation factors in the rat kidney, Bendayan, M., Vinay, P., Bourgoin, S., Marshansky, V., Londono, I., Kidney International, 1999, 10.1046/j.1523-1755.1999.00365.x
  • Crystal-induced neutrophil activation VI. Involvement of FcγRIIIB (CD16) and CD11b in response to inflammatory microcrystals, Naccache, P.H., Bourgoin, S.G., Liao, N., Barabé, F., Gilbert, C., FASEB Journal, 1998
  • Expression and activity of prostaglandin endoperoxide synthase-2 in agonist-activated human neutrophils, Naccache, P.H., McColl, S.R., Maclouf, J., Créminon, C., Bourgoin, S., Poubelle, P.E., Borgeat, P., Gilbert, C., Pouliot, M., FASEB Journal, 1998
  • Differential expression of adenosine receptors in human neutrophils: Up-regulation by specific Th1 cytokines and lipopolysaccharide, Bourgoin, S., Borgeat, P., Fernandes, M., Harbour, D., Fortin, A., Journal of Leukocyte Biology, 2006, 10.1189/jlb.0505249
  • Effects of pyrrophenone, an inhibitor of group IVA phospholipase A2, on eicosanoid and PAF biosynthesis in human neutrophils, Borgeat, P., Bourgoin, S.G., Pouliot, M., Lemieux, L., Picard, S., Flamand, N., British Journal of Pharmacology, 2006, 10.1038/sj.bjp.0706879
  • EFA6, Exchange Factor for ARF6, Regulates the Actin Cytoskeleton and Associated Tight Junction in Response to E-Cadherin Engagement, Chardin, P., Franco, M., Bourgoin, S., Le Bivic, A., Chauvin, J.-P., Klein, S., Luton, F., Molecular Biology of the Cell, 2004, 10.1091/mbc.E03-10-0751
  • Phospholipases D1 and D2 coordinately regulate macrophage phagocytosis, Kusner, D.J., Bourgoin, S., Barton, J.A., Iyer, S.S., Journal of Immunology, 2004, 10.4049/jimmunol.173.4.2615
  • Prostaglandin E2inhibits the phospholipase D pathway stimulated by formyl-methionyl-leucyl-phenylalanine in human neutrophils. Involvement of EP2receptors and phosphatidylinositol 3-kinase γ, Bourgoin, S.G., Naccache, P.H., Simard, S., Levasseur, S., Thibault, N., Burelout, C., Molecular Pharmacology, 2004, 10.1124/mol.66.2.293
  • TNF-α promotes LPA1- and LPA3-mediated recruitment of leukocytes in vivo through CXCR2 ligand chemokines, Bourgoin, S.G., Fernandes, M.J., Poubelle, P.E., Chun, J., Sardella, A., Zhao, C., Journal of Lipid Research, 2011, 10.1194/jlr.M008045
  • Cytohesin-1 regulates the Arf6-phospholipase D signaling axis in human neutrophils: Impact on superoxide anion production and secretion, Bourgoin, S.G., Pivot-Pajot, C., Harbour, D., Garceau, V., El Azreq, M.-A., Journal of Immunology, 2010, 10.4049/jimmunol.0901654
  • Protein kinase Cζ regulates phospholipase D activity in rat-1 fibroblasts expressing the α1A adrenergic receptor, Malik, K.U., Bourgoin, S.G., Saeed, A.E., Wiggins, M.T., Gandhi, G.K., Parmentier, J.-H., BMC Cell Biology, 2004, 10.1186/1471-2121-5-4
  • Altered formation of leukotriene B4in vitro by synovial fluid neutrophils in rheumatoid arthritis, Borgeat, P., Beaulieu, A.D., Nguyen, M.-H., McColl, S.R., Bourgoin, S., Poubelle, P.E., Journal of Rheumatology, 1989
  • Interactions of SIN-1 with the generation of cyclic nucleotides and arachidonate metabolites in the uterine smooth muscle,INTERACTIONS DU SIN-1 AVEC LA GENERATION DES NUCLEOTIDES CYCLIQUES ET DES METABOLITES OXYDES DE L'ARACHIDONATE DANS LE MUSCLE UTERIN, Harbon, S., Leiber, D., Bourgoin, S., Pathologie Biologie, 1987
  • Cytohesin-1 regulates human blood neutrophil adhesion to endothelial cells through β2 integrin activation, Bourgoin, S.G., El azreq, M.-A., Molecular Immunology, 2011, 10.1016/j.molimm.2011.03.018
  • Cytohesin-1 regulates fMLF-mediated activation and functions of the β2integrin Mac-1 in human neutrophils, Bourgoin, S.G., Garceau, V., el Azreq, M.-A., Journal of Leukocyte Biology, 2011, 10.1189/jlb.0410222
  • Phospholipase A1 Member A Deficiency Alleviates Mannan-Induced Psoriatic Arthritis in Mice Model, Sylvain G. Bourgoin, Fawzi Aoudjit, Yang Zhao, International Journal of Molecular Sciences, 2022, 10.3390/ijms23158559
  • Lipoxygenase and cyclooxygenase products of arachidonic acid in uterus. Selective interaction with the cGMP and cAMP systems, Harbon, S., Leiber, D., Bourgoin, S., Vesin, M.F., Prostaglandins, Leukotrienes and Medicine, 1984, 10.1016/0262-1746(84)90105-7
  • Effect of molsidomine derivative (SIN-1) on leukotriene synthesis in human leukocytes,EFFET DU SIN-1 SUR LA SYNTHESE DE LEUCOTRIENES DANS LES POLYMORPHONUCLEAIRES HUMAINS, Borgeat, P., Poubelle, P., Bourgoin, S., Pathologie Biologie, 1987
  • Granulocyte-macrophage colony-stimulating factor primes phospholipase D activity in human nerutrophils in vitro: Role of calcium, G-proteins and tyrosine kinases, Naccache, P.H., Borgeat, P., Emezawa, K., Liao, N.W., Poubelle, P.E., Bougoin, S., Cellular Signalling, 1992, 10.1016/0898-6568(92)90018-4
  • Priming of calcium mobilization in human neutrophils by granulocyte-macrophage colony-stimulating factor: Evidence for an involvement of phospholipase D-derived phosphatidic acid, Bourgoin, S., Gaudry, M., Hamelin, B., Naccache, P.H., Cellular Signalling, 1991, 10.1016/0898-6568(91)90040-2
  • C2-ceramide primes specifically for the superoxide anion production induced by N-formylmethionylleucyl phenylalanine (fMLP) in human neutrophils, Pelletier, G., McColl, S.R., Krump, E., L'Heureux, G.P., Naccache, P.H., Bourgoin, S., Richard, A., Biochimica et Biophysica Acta - Lipids and Lipid Metabolism, 1996, 10.1016/0005-2760(95)00215-4
  • Crystal‐induced neutrophil activation. II. evidence for the activation of a phosphatidylcholine‐specific phospholipase D, Poubelle, P.E., Lussier, A., De Medicis, R., Roberge, C.J., Plante, E., Bourgoin, S., Naccache, P.H., Arthritis & Rheumatism, 1993, 10.1002/art.1780360119
  • Interference of HIV-1 Nef in the sphingomyelin transduction pathway activated by tumour necrosis factor-α in human glial cells, Poulin, L., Darveau, A., Bourgoin, S., Lapointe, R., Robichaud, G., Richard, A., AIDS, 1997, 10.1097/00002030-199701000-00001
  • Receptor-mediated endocytosis in kidney proximal tubules: Recent advances and hypothesis, Vinay, P., Maranda, B., Bendayan, M., Londoño, I., Bourgoin, S., Marshansky, V., Electrophoresis, 1997, 10.1002/elps.1150181423
  • Human phospholipase D1 can be tyrosine-phosphorylated in HL-60 granulocytes, Bourgoin, S., Naccache, P.H., Harbour, D., Marcil, J., Journal of Biological Chemistry, 1997, 10.1074/jbc.272.33.20660
  • Suppressive effects of adenosine on the 5-lipoxygenase pathway in human polymorphonuclear leukocytes, Borgeat, P., Bourgoin, S., Krump, E., Austin, M., Surette, M.E., Picard, S., Plante, H., Flamand, N., Drug Development Research, 2001, 10.1002/ddr.1140
  • Adenosine receptor occupancy suppresses chemoattractant-induced phospholipase D activity by diminishing membrane recruitment of small GTPases, Bourgoin, S.G., Naccache, P.H., Borgeat, P., Harbour, D., Thibault, N., Blood, 2000
  • Stimulation of human neutrophils by chemotactic factors is associated with the activation of phosphatidylinositol 3-kinase γ, McColl, S.R., Bourgoini, S.G., Chakravarti, S., Lachance, G., Levasseur, S., Naccache, P.H., Journal of Biological Chemistry, 2000, 10.1074/jbc.M001780200
  • Regulation of phospholipase D by phosphorylation-dependent mechanisms, Bourgoin, S., Houle, M.G., Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1999, 10.1016/S1388-1981(99)00090-6
  • Subcellular distribution and characterization of rat pancreatic phospholipase D isoforms, Morisset, J., Bourassa, J., Bourgoin, S., Lainé, J., Pancreas, 2000, 10.1097/00006676-200005000-00001
  • The role of serotonin and other neuroactive molecules in the physiopathogenesis of migraine: Current hypotheses,Implications de la serotonine et d'autres molecules neuroactives dans la physiopathogenie de la migraine. Hypotheses actuelles, Bourgoin, S., Hamon, M., Pathologie Biologie, 2000
  • Regulation of Constitutive Protein Transit by Phospholipase D in HT29-cl19A Cells, Raymond, M.-N., Frohman, M.A., Bourgoin, S., Min, D.S., Geny, B., Robin, P., Honkavaara, P., Phebidias, C., Denmat-Ouisse, L.-A., Journal of Biological Chemistry, 2001, 10.1074/jbc.M104276200
  • Phospholipase D2 is localized to the rims of the Golgi apparatus in mammalian cells, Shields, D., Bourgoin, S., Freyberg, Z., Molecular Biology of the Cell, 2002, 10.1091/mbc.02-04-0059
  • GLUT-4 translocation in skeletal muscle studied with a cell-free assay: Involvement of phospholipase D, Richter, E.A., Franco, M., Klip, A., Bourgoin, S., Nielsen, J.N., Kristiansen, S., American Journal of Physiology - Endocrinology and Metabolism, 2001
  • ARFGAP1 promotes the formation of COPI vesicles, suggesting function as a component of the coat, Hsu, V.W., Premont, R.T., Randazzo, P.A., Bourgoin, S., Gao, M., Lee, S.Y., Yang, J.-S., Journal of Cell Biology, 2002, 10.1083/jcb.200206015
  • Cholesterol-modulating agents selectively inhibit calcium influx induced by chemoattractants in human neutrophils, Naccache, P.H., Bourgoin, S.G., Fernandes, M.J.G., Paré, G., Barabé, F., Journal of Biological Chemistry, 2002, 10.1074/jbc.M112149200
  • Arachidonic acid activates phospholipase D in human neutrophils; essential role of endogenous leukotriene B4and inhibition by adenosine A2Areceptor engagement, Bourgoin, S.G., Borgeat, P., Naccache, P.H., Pelletier, J., Flamand, N., Grenier, S., Journal of Leukocyte Biology, 2003, 10.1189/jlb.0702371
  • Dissociation between the translocation and the activation of Akt in fMLP-stimulated human neutrophils - Effect of prostaglandin E2, Bourgoin, S.G., Naccache, P.H., Burelout, C., Journal of Leukocyte Biology, 2007, 10.1189/jlb.0406256
  • The PGE2-induced inhibition of the PLD activation pathway stimulated by fMLP in human neutrophils is mediated by PKA at the PI3-Kγ level, Bourgoin, S.G., Naccache, P.H., Harbour, D., Thibault, N., Burelout, C., Biochemical Pharmacology, 2007, 10.1016/j.bcp.2007.06.013
  • Inhibition of platelet-activating factor biosynthesis by adenosine and histamine in human neutrophils: Involvement of cPLA2α and reversal by lyso-PAF, Borgeat, P., Picard, S., Lemieux, L., Bourgoin, S.G., Lapointe, G., Lefebvre, J., Flamand, N., Journal of Leukocyte Biology, 2006, 10.1189/jlb.1005614
  • ACAP1 promotes endocytic recycling by recognizing recycling sorting signals, Hsu, V.W., Peters, P.J., Bourgoin, S., Premont, R.T., Porcionatto, M., Bos, E., Li, J., Dai, J., Developmental Cell, 2004, 10.1016/j.devcel.2004.10.002
  • Cross-talk between CD14 and complement receptor 3 promotes phagocytosis of mycobacteria: Regulation by phosphatidylinositol 3-kinase and cytohesin-1, Hmama, Z., Talal, A., Bourgoin, S., Lee, J.S.I., Reiner, N.E., Sendide, K., Journal of Immunology, 2005, 10.4049/jimmunol.174.7.4210
  • Lysophosphatidic acid-induced IL-8 secretion involves MSK1 and MSK2 mediated activation of CREB1 in human fibroblast-like synoviocytes, Bourgoin, S.G., Poubelle, P.E., Fernandes, M.J., Hui, W., Zhao, C., Biochemical Pharmacology, 2014, 10.1016/j.bcp.2014.04.012
  • An essential role for phospholipase D in the recruitment of vesicle amine transport protein-1 to membranes in human neutrophils, Bourgoin, S.G., El azreq, M.-A., Harbour, D., Faugaret, D., Chouinard, F.C., Biochemical Pharmacology, 2011, 10.1016/j.bcp.2010.09.014
  • Autotaxin and lysophospholipids in rheumatoid arthritis, Zhao, C., Bourgoin, S.G., Current Opinion in Investigational Drugs, 2010
  • Characterisation of degranulation and phagocytic capacity of a human neutrophilic cellular model, PLB-985 cells, Bourgoin, S.G., Harbour, D., Amine El Azreq, M., Chouinard, F.C., Pivot-Pajot, C., Immunobiology, 2010, 10.1016/j.imbio.2009.01.007
  • A role for phosphatidic acid in COPI vesicle fission yields insights into Golgi maintenance, Hsu, V.W., Luini, A., Frohman, M.A., Bourgoin, S., Graziani, A., Baldanzi, G., Du, G., Bonsra, A.N., Turacchio, G., Valente, C., Beznoussenko, G.V., Zhang, L., Mironov, A., Lee, S.Y., Gad, H., Yang, J.-S., Nature Cell Biology, 2008, 10.1038/ncb1774
  • Munc13-4 regulates granule secretion in human neutrophils, Bourgoin, S.G., De Saint Basile, G., Varoqueaux, F., Pivot-Pajot, C., Journal of Immunology, 2008, 10.4049/jimmunol.180.10.6786
  • Regulation of lysophosphatidic acid receptor expression and function in human synoviocytes: Implications for rheumatoid arthritis?, Bourgoin, S.G., Poubelle, P.E., Clair, T., Di Battista, J., Turgeon, M., Prestwich, G.D., Fernandes, M.J., Zhao, C., Molecular Pharmacology, 2008, 10.1124/mol.107.038216
  • Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules, Eric Boilard, Benoît Vingert, Mélanie Dieudé, Bogdan Iulius Florea, Herman S. Overkleeft, France Pirenne, Marie-Josée Hébert, John Semple, Rick Kapur, Fabrice Cognasse, Hind HAMZEH-COGNASSE, Sylvain Bourgoin, Julie Turgeon, Annie Karakeussian Rimbaud, Johan Rebetz, Tania Lévesque, Anne Zufferey, Isabelle Allaeys, Marie Tamagne, Maroua Mbarik, Marie Bellio, Stephan Hasse, Audrée Laroche, Genevieve Marcoux, Blood, 2021, 10.1182/blood.2020009957
  • Interplay between LPA2 and LPA3 in LPA-mediated phosphatidylserine cell surface exposure and extracellular vesicles release by erythrocytes, Sylvain G. Bourgoin, Eric Boilard, Paul Fortin, Anne-Claire Duchez, Stephan Hasse, Sylvain Bourgoin, Biochemical Pharmacology, 2021, 10.1016/j.bcp.2021.114667
  • Assessment of Arf6 Deletion in PLB-985 Differentiated in Neutrophil-Like Cells and in Mouse Neutrophils: Impact on Adhesion and Migration, Sylvain G. Bourgoin, Fawzi Aoudjit, Yasunori Kanaho, Yuji Funakoshi, Tsunaki Hongu, Emmanuelle Rollet-Labelle, Lynn Davis, Jouda Gamara, Mediators of Inflammation, 2020, 10.1155/2020/2713074
  • Phospholipase D2 in prostate cancer: protein expression changes with Gleason score, Martin G. Rumsby, Norman J. Maitland, Sylvain Bourgoin, Daniel M. Berney, Rakesh Suman, Karen Hogg, Amanda R. Noble, Sylvain Bourgoin, British Journal of Cancer, 2019, 10.1038/s41416-019-0610-7
  • Targeting the autotaxin – Lysophosphatidic acid receptor axis in cardiovascular diseases, Sylvain G. Bourgoin, Chenqi Zhao, Stephan Hasse, Yang Zhao, Biochemical Pharmacology, 2019, 10.1016/j.bcp.2019.03.035
  • A transgenic mouse model for the in vivo bioluminescence imaging of the expression of the lysophosphatidic acid receptor 3: relevance for inflammation and uterine physiology research, Maria J. Fernandes, Sylvain G. Bourgoin, Patrice E. Poubelle, Lynn Davis, Anne Sardella, Chenqi Zhao, Sylvain Bourgoin, Transgenic Research, 2015, 10.1007/s11248-015-9882-8
  • Chemical Hypoxia Brings to Light Altered Autocrine Sphingosine-1-Phosphate Signalling in Rheumatoid Arthritis Synovial Fibroblasts, Bourgoin, S.G., Touaibia, M., Fernandes, M.J., Di Battista, J.A., Moreno-Nieves, U., Zhao, C., Mediators of Inflammation, 2015, 10.1155/2015/436525
  • LPA promotes T cell recruitment through synthesis of CXCL13, Bourgoin, S.G., Zhao, C., Hui, W., Mediators of Inflammation, 2015, 10.1155/2015/248492

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Kenza Azoudj - Maîtrise avec mémoire - En cours
  • Marouane Bouabane - Maîtrise avec mémoire - En cours
  • Weili Hui - Doctorat - 2017/01
  • Jadson Moreira Pereira - Doctorat - 2019/05
  • Jouda Gamara - Doctorat - 2020/05
  • Lisa Auclert - Maîtrise avec mémoire - 2020/09
  • Stephan Hasse - Doctorat - 2021/09
  • Yang Zhao - Doctorat - 2022/05

Encadrement d'étudiant(e)s pour les programmes suivants :

*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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