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Steve Bilodeau

Professeur titulaire

Steve Bilodeau
Centre de recherche sur le cancer
Centre de recherche en données massives
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Bioinformatique / données massives (big data)
Oncologie

Domaines et intérêts de recherche du (de la) professeur(e) :

Cancer
  • Cancer la prostate
  • Cancers hormonaux-dépendants
  • Diagnostic et détection du cancer
  • Génétique du cancer
Génétique humaine
  • Chromosomes : structure/organisation
  • Expression et régulation génique
  • Génomique
Cellulaire
Génomique et protéomique
  • Bio-informatique

Projets de recherche

  • Defining the global transcriptional response to perturbations - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2021-04-01 au 2026-03-31
  • Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
  • Elucidation of bromodomain functions within SWI/SNF complexes - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2020-04-01 au 2025-03-31
  • Toward defining the transcriptional ecosystem - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC), Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2019-04-01 au 2024-03-31
  • Targeting the master transcription factor HSF1 in endocrine-resistant breast cancer to restore antiestrogen response - Société de recherche sur le cancer - Subvention de fonctionnement, chercheur principal - 2021-09-01 au 2023-08-31
  • Canadian Epigenetics, Environment and Health Research Consortium Network Phase II - Instituts de recherche en santé du Canada - Subvention de fonctionnement : CEEHRC (Epigénétique), University of British Columbia, co-chercheur - 2019-07-01 au 2023-06-30
  • What are my options? A feasibility study of a personalized primary prevention strategy for women and men at high risk of breast and prostate cancer - Instituts de recherche en santé du Canada, Fondation du cancer du sein du Québec, Société canadienne du cancer - Initiative SCC/IC-IRSC en prévention primaire du cancer, co-chercheur - 2022-01-15 au 2023-01-14
  • Chaire de recherche du Canada en génomique transcriptionnelle - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2017-09-01 au 2022-08-31
  • Using BET bromodomain inhibitors to create phenotypic lethality in melanoma - Société de recherche sur le cancer, Génome Québec - Subvention de fonctionnement, co-chercheur - 2020-09-01 au 2022-08-31

Publications

  • Du mécanisme moléculaire de la résistance hormonale à la tumorigénèse dans la maladie de Cushing, , Université de Montréal, 2007
  • Genes on Different Strands Mark Boundaries Associated with Co-regulation Domains, , 2020, 10.1101/2020.09.22.303438
  • Editorial: The Evolving Chromatin and Transcriptional Landscapes-Emerging Methods, Tools and Techniques., , Frontiers in cell and developmental biology, 2021, 10.3389/fcell.2021.782776
  • Effects of granulosa cell co-culture on in-vitro meiotic resumption of bovine oocytes, Bilodeau, S., Sirard, M.A., Journal of Reproduction and Fertility, 1990, 10.1530/jrf.0.0890459
  • Retinoblastoma and the related pocket protein p107 act as coactivators of NeuroD1 to enhance gene transcription., , The Journal of Biological Chemistry, 2005, 10.1074/jbc.m413427200
  • Effect of adenylate cyclase stimulation on meiotic resumption and cyclic AMP content of zona-free and cumulus-enclosed bovine oocytes in vitro, Sirard, M.A., Fortier, M.A., Bilodeau, S., Journal of Reproduction and Fertility, 1993, 10.1530/jrf.0.0970005
  • The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset., , Nature, 2011, 10.1038/nature09806
  • The T-box factor Tpit recruits SRC/p160 co-activators and mediates hormone action., , The Journal of Biological Chemistry, 2003, 10.1074/jbc.m305626200
  • Enhancer decommissioning by LSD1 during embryonic stem cell differentiation., , Nature, 2012, 10.1038/nature10805
  • Rb enhances p160/SRC coactivator-dependent activity of nuclear receptors and hormone responsiveness., , The Journal of Biological Chemistry, 2005, 10.1074/jbc.m413428200
  • SHP-1 phosphatase acts as a coactivator of PCK1 transcription to control gluconeogenesis, André Marette, Mathieu Laplante, Steve Bilodeau, Anne-Claude Gingras, Nicole Beauchemin, Kerstin Bellmann, Éric Fournier, Marilyn Goudreault, Maruhen Amir Datsch Silveira, Beisy Laborit Labrada, Michael Schwab, Amit Kumar, Journal of Biological Chemistry, 2023, 10.1016/j.jbc.2023.105164
  • Defining the Transcriptional Ecosystem, Steve Bilodeau, Maruhen A.D. Silveira, Molecular Cell, 2018, 10.1016/j.molcel.2018.11.022
  • Connected Gene Communities Underlie Transcriptional Changes in Cornelia de Lange Syndrome., , Genetics, 2017, 10.1534/genetics.117.202291
  • SetDB1 contributes to repression of genes encoding developmental regulators and maintenance of ES cell state., , Genes & Development, 2009, 10.1101/gad.1837309
  • Control of adipogenic commitment by a STAT3-VSTM2A axis., , American journal of physiology. Endocrinology and metabolism, 2020, 10.1152/ajpendo.00314.2020
  • Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner., , Molecular & cellular proteomics : MCP, 2021, 10.1016/j.mcpro.2021.100064
  • Uncoupled precursor cell cycle exit and differentiation, , Developmental Biology, 2007, 10.1016/j.ydbio.2007.03.157
  • FOXA and master transcription factors recruit Mediator and Cohesin to the core transcriptional regulatory circuitry of cancer cells., , Scientific Reports, 2016, 10.1038/srep34962
  • The gut-liver axis: host microbiota interactions shape hepatocarcinogenesis., , Trends in cancer, 2022, 10.1016/j.trecan.2022.02.009
  • Effect of fresh or cultured follicular fractions on meiotic resumption in bovine oocytes, Bilodeau, S., Coenen, K., Sirard, M.A., Theriogenology, 1992, 10.1016/0093-691X(92)90246-N
  • Granulosa cells inhibit the resumption of meiosis in bovine oocytes in vitro, Bilodeau, S., Sirard, M.A., Biology of Reproduction, 1990, 10.1095/biolreprod43.5.777
  • Protein-protein interactions and transcriptional antagonism between the subfamily of NGFI-B/Nur77 orphan nuclear receptors and glucocorticoid receptor., , Molecular Endocrinology, 2005, 10.1210/me.2004-0333
  • Subversion of infiltrating prostate macrophages to a mixed immunosuppressive tumor-associated macrophage phenotype., , Clinical and translational medicine, 2022, 10.1002/ctm2.581
  • Compositions and methods for enhancing cell reprogramming, , US patent, 2009
  • Erratum to: Enhancer decommissioning by LSD1 during embryonic stem cell differentiation (Nature, (2012), 482, 7384, (221-225), 10.1038/nature10805), Young, R.A., Cowley, S.M., Foster, C.T., Frampton, G.M., Hoke, H.A., Orlando, D.A., Bilodeau, S., Whyte, W.A., Nature, 2018, 10.1038/s41586-018-0487-2
  • Master transcription factors determine cell-type-specific responses to TGF-β signaling., , Cell, 2011, 10.1016/j.cell.2011.08.050
  • Cis-regulatory hubs: a new 3D model of complex disease genetics with an application to schizophrenia, Alexandre Bureau, Steve Bilodeau, Arnaud Droit, Charles Joly-Beauparlant, Loïc Mangnier, Life Science Alliance, 2022, 10.26508/lsa.202101156
  • Modulating HSF1 levels impacts expression of the estrogen receptor α and antiestrogen response, Steve Bilodeau, Arnaud Droit, Maxime C Côté, Éric Fournier, Mickaël Leclercq, Tania Cuppens, Félix-Antoine Bérube-Simard, Christophe Tav, Maruhen AD Silveira, Life Science Alliance, 2021, 10.26508/lsa.202000811
  • Distinct developmental roles of cell cycle inhibitors p57Kip2 and p27Kip1 distinguish pituitary progenitor cell cycle exit from cell cycle reentry of differentiated cells., , Molecular and Cellular Biology, 2009, 10.1128/mcb.01885-08
  • Mediator and cohesin connect gene expression and chromatin architecture., , Nature, 2010, 10.1038/nature09380
  • Wnt signaling promotes reprogramming of somatic cells to pluripotency., , Cell Stem Cell, 2008, 10.1016/j.stem.2008.06.019
  • Multiple structural maintenance of chromosome complexes at transcriptional regulatory elements., , Stem Cell Reports, 2013, 10.1016/j.stemcr.2013.09.002
  • Expression and mutation analysis of Tpit in the canine pituitary gland and corticotroph adenomas., , Domestic Animal Endocrinology, 2008, 10.1016/j.domaniend.2007.03.002
  • Role of Brg1 and HDAC2 in GR trans-repression of the pituitary POMC gene and misexpression in Cushing disease., , Genes & Development, 2006, 10.1101/gad.1444606
  • Cooperation between cyclin E and p27(Kip1) in pituitary tumorigenesis., , Molecular Endocrinology, 2010, 10.1210/me.2010-0091
  • Mutant cohesin affects RNA polymerase II regulation in Cornelia de Lange syndrome., , Scientific Reports, 2015, 10.1038/srep16803
  • Stem cells, differentiation and cell cycle control in pituitary., , Frontiers of hormone research, 2010, 10.1159/000318490
  • Compositions and methods for enhancing cell reprogramming, , US patent, 2012
  • HSP70 mediates a crosstalk between the estrogen and the heat shock response pathways, Steve Bilodeau, Jean-Yves Masson, Divya Naik, Sofiane Yacine Mersaoui, Fatemeh Khadangi, Maruhen Amir Datsch Silveira, Journal of Biological Chemistry, 2023, 10.1016/j.jbc.2023.102872
  • X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner., , Proceedings of the National Academy of Sciences (PNAS), 2012, 10.1073/pnas.1210787109
  • ZNF768 links oncogenic RAS to cellular senescence., , Nature communications, 2021, 10.1038/s41467-021-24932-w
  • metagene Profiles Analyses Reveal Regulatory Element's Factor-Specific Recruitment Patterns., , PLoS Computational Biology, 2016, 10.1371/journal.pcbi.1004751
  • Of old and new diseases: genetics of pituitary ACTH excess (Cushing) and deficiency., , Clinical genetics, 2007, 10.1111/j.1399-0004.2007.00877.x
  • Mediator and cohesin connect gene expression and chromatin architecture (Nature (2010) 467 (430-435)), Young, R.A., Dekker, J., Taatjes, D.J., Levine, S.S., Rahl, P.B., Goossens, J., Ebmeier, C.C., Van Berkum, N.L., Orlando, D.A., Zhan, Y., Bilodeau, S., Newman, J.J., Kagey, M.H., Nature, 2011, 10.1038/nature09930
  • A chromatin switch for chromosome condensation., , Developmental Cell, 2012, 10.1016/j.devcel.2012.11.016
  • Mediator and cohesin connect gene expression and chromatin architecture, , US patent, 2013
  • ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state., , Cell Reports, 2014, 10.1016/j.celrep.2013.12.032

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Divya Naik - Doctorat - En cours
  • Sourav Mahato - Doctorat - En cours
  • Christophe Tav - Doctorat - En cours
  • Cristopher Segovia Bravo - Post-doctorat - En cours
  • Sevinj Yolchuyeva - Post-doctorat - En cours
  • Gaëlle Bourriquen - Maîtrise avec mémoire - 2016/09
  • Romain Villot - Doctorat - 2021/01
  • Maruhen Amir Datsch Silveira - Doctorat - 2022/05

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.