Découvrez nos professeurs et professeures!

Sébastien Thériault

Médecin clinicien enseignant sous octroi adjoint

sebastien.theriault@criucpq.ulaval.ca

Dép. biologie moléculaire, biochimie médicale et pathologie

Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec

Centre de recherche de l'IUCPQ

Partager la fiche :

Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Bioinformatique / données massives (big data)

Médecine régénératrice et médecine moléculaire

Santé cardiovasculaire, respiratoire et métabolisme

Domaines et intérêts de recherche du (de la) professeur(e) :

Génétique humaine

Génétique de traits complexes
Génomique
Expression et régulation génique
Gènes de susceptibilité
Micropuces d'ADN et d'ARN
Dépistage génétique des maladies

Santé circulatoire et respiratoire

Maladie coronarienne
Maladies cardiovasculaires
Athérosclérose
Hypertension artérielle
Valves cardiaques/maladies valvulaires

Projets de recherche

Unraveling TWIST1 interactome and its contribution in the pathogenesis of calcific aortic valve stenosis - Fondation de l'Institut universitaire de cardiologie et de pneumologie de Québec, chercheur principal - 2024-01-01 au 2025-12-31
A transcriptome- and proteome-wide association study of non-alcoholic fatty liver disease - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2021-10-01 au 2024-09-30
Integrative genomics and functional analyses to uncover the molecular mechanisms involved in bicuspid aortic valve disease - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2019-04-01 au 2024-03-31
Finding the molecular drivers of calcific aortic valve stenosis - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2018-10-01 au 2023-03-31
FEI du projet « Integrative genomics in cardiometabolic diseases » - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), chercheur principal - 2021-07-01 au 2023-03-31
Séquençage du transcriptome des cellules individuelles sur tissus de valve aortique humaine - Fondation de l'Institut universitaire de cardiologie et de pneumologie de Québec, chercheur principal - 2022-01-01 au 2022-12-31
Identification of novel therapeutic targets for calcific aortic valve stenosis using integrative genomics - Fondation des maladies du coeur et de l'AVC du Canada - Subventions de recherche, chercheur principal - 2019-07-01 au 2022-06-30
Déterminants moléculaires et environnementaux de l’adiposité viscérale et du risque cardio-métabolique : un pas vers la médecine personnalisée - Fonds de recherche du Québec - Santé - Chercheurs-boursiers cliniciens - Juniors 1 et 2, Seniors, chercheur principal - 2018-07-01 au 2022-06-30
Déterminants moléculaires et environnementaux de l’adiposité viscérale et du risque cardio-métabolique : un pas vers la médecine personnalisée - Fonds de recherche du Québec - Santé - Établissement de jeunes chercheurs - Juniors 1, chercheur principal - 2018-07-01 au 2022-06-30
Multi-omic approach to sex-differences in aortic stenosis - Fondation des maladies du coeur et de l'AVC du Canada, co-chercheur - 2021-07-01 au 2022-06-30

...

Publications

Screening for pre-eclampsia early in pregnancy: Performance of a multivariable model combining clinical characteristics and biochemical markers, Forest, J.-C., Rousseau, F., Lafond, J., Bujold, E., Thériault, S., Massé, J., Giguère, Y., BJOG: An International Journal of Obstetrics and Gynaecology, 2015, 10.1111/1471-0528.13050
Genetic inhibition of PCSK9, atherogenic lipoprotein concentrations, and calcific aortic valve stenosis, Arsenault, B.J., Poggio, P., Thériault, S., Camera, M., Smith, J.G., Pibarot, P., Bossé, Y., Mathieu, P., Thanassoulis, G., Engert, J.C., Chen, H.Y., Dina, C., Wareham, N.J., Clavel, M.-A., Mass, E., Capoulade, R., Martinsson, A., Valerio, V., Boekholdt, S.M., Moschetta, D., Perrot, N., bioRxiv, 2019, 10.1101/560458
Genome-wide chromatin contacts of super-enhancer-associated lncRNA identify LINC01013 as a regulator of fibrosis in the aortic valve, Patrick Mathieu, Yohan Bossé, Sébastien Thériault, Zhonglin Li, Valentin Bon-Baret, Ghada Mkannez, Marie-Chloé Boulanger, Déborah Argaud, Arnaud Chignon, PLOS Genetics, 2022, 10.1371/journal.pgen.1010010
Electronic health record-based genome-wide meta-analysis provides insights on the genetic architecture of non-alcoholic fatty liver disease, Arsenault, B.J., Esko, T., Khera, A.V., Thériault, S., Tchernof, A., Vohl, M.-C., Mathieu, P., Bossé, Y., Mitchell, P.L., Couture, C., St-Amand, A., Bourgault, J., Gagnon, É., Manikpurage, H.D., Perrot, N., Haas, M.E., Taba, N., Gobeil, É., Emdin, C.A., Abner, E., Ghodsian, N., Cell Reports Medicine, 2021, 10.1016/j.xcrm.2021.100437
Genetic analysis of over one million people identifies 535 novel loci for blood pressure., Caulfield, M.J., Elliott, P., Wain, L.V., Barnes, M.R., Tzoulaki, I., Psaty, B.M., Edwards, T.L., O’Donnell, C.J., Hung, A.M., Metspalu, A., Brown, M.J., Zeggini, E., Wareham, N.J., van der Harst, P., Spector, T.D., Sever, P., Scott, R.J., Scott, R.A., Risch, L., Palmer, C.N.A., Munroe, P.B., Mook-Kanamori, D.O., Melander, O., Langenberg, C., Lakatta, E.G., Laakso, M., Howson, J.M.M., Hayward, C., Danesh, J., Cucca, F., Conen, D., Chasman, D., Butterworth, A.S., Attia, J.R., Zhang, W., Zemunik, T., Yao, J., Wright, A.F., Wilson, J.F., Willemsen, G., Wild, S.H., Watkins, H., Vuckovic, D., Vollenweider, P., Völker, U., Vitart, V., Verwoert, G.C., Vergnaud, A.-C., van Duijn, C.M., van der Most, P.J., Vaez, A., Uitterlinden, A.G., Tzourio, C., Tuomilehto, J., Trompet, S., Traglia, M., Toniolo, D., Tobin, M.D., Teumer, A., Taylor, K.D., Swertz, M.A., Sundström, J., Strawbridge, R.J., Strachan, D.P., Stott, D.J., Starr, J.M., Sorice, R., Sõber, S., Snieder, H., Smith, A.V., Siscovick, D., Shrine, N., Schmidt, H., Schmidt, R., Sarin, A.-P., Samani, N.J., Salomaa, V., Sala, C.F., Saba, Y., Ruggiero, D., Rudan, I., Rotter, J.I., Rose, L.M., Robino, A., Ripatti, S., Riese, H., Ried, J.S., Ridker, P.M., Rice, K., Rettig, R., Ren, M., Raitakari, O.T., Tri, N.Q., Pramstaller, P.P., Polasek, O., Peters, A., Perola, M., Penninx, B.W.J.H., Pattie, A., Palotie, A., Palmas, W., Padmanabhan, S., Org, E., O'Reilly, P.F., Oostra, B.A., Oldehinkel, A.J., Nolte, I.M., Nutile, T., Nelson, C.P., Newton-Cheh, C., Niiranen, T., Nandakumar, P., Nalls, M.A., Munson, P.J., Morrison, A.C., Morris, A.P., Morgan, A., Milaneschi, Y., Marten, J., Marrugat, J., Mamasoula, C., Mahajan, A., Lyytikäinen, L.-P., Lu, Y., Lopez, L.M., Loos, R.J.F., Liu, Y., Lindgren, C.M., Lind, L., Lin, L., Liewald, D.C.M., Levy, D., Lehtimäki, T., Lehne, B.C., Launer, L.J., Larson, M., Laan, M., Kutalik, Z., Kristiansson, K., Koskinen, S., Kooner, J.S., Kolcic, I., Knight, J., Knekt, P., Khaw, K.-T., Keavney, B.D., Kathiresan, S., Kähönen, M., Jula, A., Wouter Jukema, J., Jousilahti, P., Joshi, P.K., Johnson, A.D., Johansson, Å., Joehanes, R., Jarvelin, M.-R., Jansen, R., James, A., Ingelsson, E., Hwang, S.-J., Huffman, J.E., Hottenga, J.-J., Hofman, A., Hofer, E., Hicks, A.A., Havulinna, A.S., Hartman, C.A., Harris, S.E., Harris, T.B., Hamsten, A., Gyllensten, U., Guo, X., Gudnason, V., Gow, A.J., Goel, A., Girotto, G., Gieger, C., Giedraitis, V., Gasparini, P., Gandin, I., Franco, O.H., Frånberg, M., Ferreira, T., Mesut Erzurumluoglu, A., Enroth, S., Elosua, R., Ehret, G.B., Dörr, M., Demirkale, C.Y., Del Greco, F.M., Deelen, J., Deary, I.J., de Geus, E.J., de Borst, M.H., Davies, G., Cordell, H.J., Collins, F., Cocca, M., Ciullo, M., Chauhan, G., Chambers, J.C., Chakravarti, A., Campbell, H., Campbell, A., Brumat, M., Braund, P.S., Bottinger, E.P., Boomsma, D.I., Boerwinkle, E., Boehnke, M., Bochud, M., Blake, T., Bis, J.C., Batini, C., Barbieri, C.M., Ayers, K.L., Arking, D.E., Amin, N., Abecasis, G., Thom, S., Stanton, A., Shields, D.C., Poulter, N.R., Paré, G., Noordam, R., Morris, A.D., Menni, C., Farrall, M., Doney, A.S.F., de Mutsert, R., Connell, J., Amouyel, P., Zhao, J.-H., Willems, S.M., Verweij, N., Thériault, S., Surendran, P., Shah, N., Sargurupremraj, M., Qian, Y., Prins, B., Oldmeadow, C., Mangino, M., Luan, J., Lin, W.-Y., Li-Gao, R., Jackson, A.U., Holliday, E.G., Giulianini, F., Ding, J., Debette, S., Boutin, T., Almgren, P., Milani, L., Mägi, R., Esko, T., Kovesdy, C.P., Tsao, P.S., Wilson, P.W.F., Michael Gaziano, J., Cho, K., Sun, Y.V., Velez-Edwards, D.R., Giri, A., Hellwege, J.N., Tzanis, E., Witkowska, K., Evangelou, M., Ng, F.L., Karaman, I., Cabrera, C.P., Dimou, N., Ntritsos, G., Gao, H., Pazoki, R., Mifsud, B., Mosen-Ansorena, D., Warren, H.R., Evangelou, E., bioRxiv, 2017, 10.1101/198234
Phenome-wide analyses establish a specific association between aortic valve PALMD expression and calcific aortic valve stenosis, Sébastien Thériault, Yohan Bossé, Patrick Mathieu, Benoit J. Arsenault, Nathalie Gaudreault, Zhonglin Li, Communications Biology, 2020, 10.1038/s42003-020-01210-x
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk, Morris, A.P., Bochud, M., Franco, O.H., Boomsma, D.I., Ingelsson, E., Palmas, W., Strachan, D.P., Wouter Jukema, J., James, A., Rettig, R., Peters, A., Psaty, B.M., Gudnason, V., van Duijn, C.M., Lehtimäki, T., Zhao, J.H., Schmidt, H., Wilson, J.F., Perola, M., Toniolo, D., Salomaa, V., Hartman, C.A., Watkins, H., Liu, Y.M., Laan, M., Gasparini, P., Scott, R.A., Hicks, A.A., Elosua, R., Ciullo, M., Deary, I.J., Knekt, P., Gyllensten, U., Tuomilehto, J., Vitart, V., Girotto, G., Starr, J.M., Polasek, O., Loos, R.J.F., Vergnaud, A.-C., Palmer, C.N.A., Spector, T.D., Zeggini, E., Mook-Kanamori, D.O., Debette, S., John, A., Conen, D., Thériault, S., Yao, J., Wright, A.F., Willemsen, G., Wild, S., Vollenweider, P., Völker, U., Uitterlinden, A.G., Tzourio, C., Taylor, K.D., Swertz, M., Sundström, J., Stott, D.J., Sorice, R., Siscovick, D., Seelen, M.A., Scott, R., Schmidt, R., Sarin, A.-P., Sala, C.F., Saint Pierre, A., Saba, Y., Rudan, I., Rotter, J.I., Robino, A., Ripatti, S., Riese, H., Ridker, P.M., Rice, K., Raitakari, O.T., Pramstaller, P.P., Penninx, B.W.J.H., Pattie, A., Paré, G., Palotie, A., Org, E., Oostra, B.A., Oldehinkel, A.J., Nutile, T., Nguyen, Q.T., Nandakumar, P., Munson, P.J., Morrison, A.C., Morris, A.D., Morgan, A., Milaneschi, Y., Menni, C., Mamasoula, C., Mach, F., Lind, L., Lin, L., Liewald, D.C.M., Lehne, B., Launer, L.J., Larson, M., Langenberg, C., Koskinen, S., Kolcic, I., Khaw, K.-T., Kathiresan, S., Kähönen, M., Jula, A., Jousilahti, P., Johnson, A.D., Johansson, Å., Jarvelin, M.-R., Holliday, E.G., Hofman, A., Harris, T.B., Hamsten, A., Gow, A.J., Giulianini, F., Gieger, C., Giedraitis, V., Frånberg, M., Ferreira, T., Dörr, M., Doney, A.S.F., Demirkale, Y., Deelen, J., de Mutsert, R., de Geus, E.J., Davies, G., Damman, J.J., Cordell, H.J., Collins, F., Cocca, M., Campbell, H., Brumat, M., Braund, P.S., Bottinger, E.P., Boehnke, M., Blake, T., Batini, C., Barbieri, C.M., Abedi, M., Abecasis, G., Oldmeadow, C., Chauhan, G., Li-Gao, R., Campbell, A., Prins, B.P., Mangino, M., de Borst, M.H., Shah, N., Lu, Y., Zemonik, T., Harris, S.E., Gandin, I., Zhang, W., Huffman, J.E., Nelson, C.P., Jackson, A.U., Enroth, S., Niiranen, T., Lopez, L.M., Ruggiero, D., Marrugat, J., Ayers, K.L., Fabiola Del Greco, M., Luan, J., Vuckovic, D., Sõber, S., Nalls, M.A., Goel, A., Havulinna, A.S., Traglia, M., Kristiansson, K., Joshi, P.K., Hofer, E., Wareham, N.J., Mahajan, A., Lyytikäinen, L.-P., Nolte, I.M., Amin, N., Smith, A.V., Bis, J.C., Ried, J.S., Teumer, A., Shrine, N., Trompet, S., Kutalik, Z., Guo, X., Hwang, S.-J., Arking, D.E., Esko, T., Strawbridge, R.J., Hottenga, J.-J., Verwoert, G.C., Rose, L.M., O'Reilly, P., Mesut Erzurumluoglu, A., van der Most, P.J., Joehanes, R., Jansen, R., Vaez, A., Wain, V., Elliott, P., Caulfield, M.J., Tzoulaki, I., Barnes, M.R., Wain, L.V., Ehret, G.B., Munroe, P.B., Tobin, M.D., Howson, J.M.M., Samani, N.J., Tomaszewski, M., Keavney, B., Kooner, J.S., Levy, D., Lindgren, C.M., Newton-Cheh, C., Chakravarti, A., Chasman, D.I., Chambers, J.C., Chowdhury, R., Saleheen, D., van der Harst, P., Hayward, C., Esko, T., Sever, P., Brown, M., Thom, S., Shields, D.C., Metspalu, A., Bakker, S.J.L., Connell, J., Stanton, A., Mägi, R., Padmanabhan, S., Gansevoort, R.T., Farrall, M., Poulter, N., Alver, M., Porteous, D., Abdullah Said, M., Shyong Tai, E., Kato, N., He, J., Knight, J., Snieder, H., O'Reilly, P.F., Segura Lepe, M.P., Karaman, I., Marten, J., Verweij, N., Loh, M., Drenos, F., Kraja, A.T., Cook, J.P., Liu, C., Surendran, P., Ntalla, I., Mifsud, B., Ren, M., Gao, H., Cabrera, C.P., Evangelou, E., Warren, H.R., Nature Genetics, 2017, 10.1038/ng.3768
Gene expression profiles for the identification of prevalent atrial fibrillation, Paré, G., Yusuf, S., Vincent, J., Raman, K., Whitlock, R., Thériault, S., Journal of the American Heart Association, 2017, 10.1161/JAHA.117.006057
Frameshift mutation in the APOA5 gene causing hypertriglyceridemia in a Pakistani family: Management and considerations for cardiovascular risk, Paré, G., Morrison, K.M., Lali, R., Chong, M., Don-Wauchope, A., Thériault, S., Journal of Clinical Lipidology, 2016, 10.1016/j.jacl.2016.07.009
Genetic Susceptibility for Atrial Fibrillation in Patients Undergoing Atrial Fibrillation Ablation, Lubitz, S., Roden, D.M., Bollmann, A., Rienstra, M., Conen, D., Sinner, M.F., Cutler, M.J., Chung, M., Nazarian, S., Natale, A., Ellinor, P., Kaä¨b, S., Michaud, G., Darbar, D., Calkins, H., Barnard, J., Hindricks, G., Van Gelder, I.C., Jacobs, V., Weeke, P., Issa, T., Wells, Q., Yoneda, Z., Montgomery, J., Müller-Nurasyid, M., Freudling, R., Van Wagoner, D.R., Smith, J.D., Aeschbacher, S., Blum, S., Geelhoed, B., Büttner, P., Zardkoohi, O., Ueberham, L., Crawford, D.M., Siland, J.E., Rinke, L.L., Thériault, S., Shaffer, C., Mohanty, S., Sun, H., Knight, S., Neumann, B., Kühne, M., Chrispin, J., Al Jazairi, M., Roselli, C., Husser, D., Shoemaker, M.B., Circulation: Arrhythmia and Electrophysiology, 2020, 10.1161/CIRCEP.119.007676
Long-Term Exposure to Elevated Lipoprotein(a) Levels, Parental Lifespan and Risk of Mortality, Boekholdt, S.M., Thériault, S., Mathieu, P., Stroes, E.S.G., Pibarot, P., Bossé, Y., Wareham, N.J., Khaw, K.-T., Couture, C., Perrot, N., Kaiser, Y., Pelletier, W., Arsenault, B.J., bioRxiv, 2019, 10.1101/615898
A multivariable Mendelian randomization analysis disentangling the causal relations between abdominal obesity, non-alcoholic fatty liver disease and cardiometabolic diseases, Arsenault, B.J., Thériault, S., Tchernof, A., Vohl, M.-C., Després, J.-P., Ghodsian, N., Mitchell, P.L., Esko, T., Taba, N., Abner, E., Maltais-Payette, I., Manikpurage, H.D., Bourgault, J., Gobeil, É., Gagnon, É., Pelletier, W., medRxiv, 2021, 10.1101/2021.09.28.21264201
Clinical experience with SERPINA1 DNA sequencing to detect alpha-1 antitrypsin deficiency, Bossé, Y., Thériault, S., Racine, C., Gaudreault, N., Maltais, F., Annals of the American Thoracic Society, 2018, 10.1513/AnnalsATS.201708-694RL
A Polygenic Risk Score for Coronary Artery Disease Improves the Prediction of Early-Onset Myocardial Infarction and Mortality in Men, Sébastien Thériault, Benoit J. Arsenault, Yohan Bossé, Patrick Mathieu, Christian Couture, Zhonglin Li, Nicolas Perrot, Aida Eslami, Hasanga D. Manikpurage, 2021, 10.1101/2021.04.25.21256083
Lipoprotein-associated phospholipase A2 activity, genetics and calcific aortic valve stenosis in humans, Arsenault, B.J., Thanassoulis, G., Bosse, Y., Mathieu, P., Schott, J.J., Smith, J.G., Pibarot, P., Clavel, M.-A., Wareham, N.J., Engert, J.C., Messika-Zeitoun, D., Le Tourneau, T., Capoulade, R., Boekholdt, S.M., Martinsson, A., Dina, C., Chen, H.Y., Rigade, S., Theriault, S., Perrot, N., Heart, 2020, 10.1136/heartjnl-2020-316722
A false-positive troponin assay leading to the misdiagnosis of myopericarditis, Steinberg, C., Thériault, S., Turgeon, P.Y., Laguë, M., CMAJ, 2022, 10.1503/CMAJ.211842
A trans-omic Mendelian randomization study of parental lifespan uncovers novel aging biology and drug candidates for human healthspan extension, Arsenault, B.J., Mathieu, P., Thériault, S., Bossé, Y., Ghodsian, N., Mitchell, P., Li, Z., Couture, C., Bourgault, J., Pelletier, W., Perrot, N., medRxiv, 2020, 10.1101/2020.07.06.20147520
A multidimensional Mendelian randomization study on the impact of gut dysbiosis on chronic diseases and human longevity, Benoit J. Arsenault, Patrick Mathieu, Sébastien Thériault, Nooshin Ghodsian, Tõnu Esko, Nele Taba, Erik Abner, Hasanga Manikpurage, Patricia L. Mitchell, Éloi Gagnon, 2021, 10.1101/2021.08.20.21262026
Enhancer-associated aortic valve stenosis risk locus 1p21.2 alters NFATC2 binding site and promotes fibrogenesis, Mathieu, P., Bossé, Y., Thériault, S., Gosselin, D., Gaudreault, N., Rufiange, A., Li, Z., Mkannez, G., Bon-Baret, V., Devillers, R., Argaud, D., Boulanger, M.-C., Rosa, M., Chignon, A., iScience, 2021, 10.1016/j.isci.2021.102241
System Genetics Including Causal Inference Identify Immune Targets for Coronary Artery Disease and the Lifespan, Patrick Mathieu, Yohan Bossé, Sébastien Thériault, Benoit J. Arsenault, Deborah Argaud, Zhonglin Li, Marie-Chloé Boulanger, Arnaud Chignon, Valentin Bon-Baret, Circulation: Genomic and Precision Medicine, 2021, 10.1161/CIRCGEN.120.003196
A false-positive troponin assay leading to the misdiagnosis of myopericarditis,Résultat de troponine faux positif à l'origine d'un diagnostic erroné de myopéricardite, Steinberg, C., Thériault, S., Turgeon, P.Y., Laguë, M., CMAJ. Canadian Medical Association Journal, 2022, 10.1503/cmaj.211842-f
Long-Term Exposure to Elevated Lipoprotein(A) Levels Influences Human Longevity, Boekholdt, S.M., Thériault, S., Mathieu, P., Stroes, E.S.G., Pibarot, P., Bossé, Y., Wareham, N.J., Khaw, K.-T., Couture, C., Perrot, N., Kaiser, Y., Pelletier, W., Arsenault, B., SSRN, 2019, 10.2139/ssrn.3404259
Factors independently associated with cardiac troponin I levels in young and healthy adults from the general population, Conen, D., Paré, G., Risch, L., Mueller, C., Risch, M., Todd, J., Estis, J., von Rotz, M., Kunz, S., Schoen, T., Aeschbacher, S., Thériault, S., Bossard, M., Clinical Research in Cardiology, 2017, 10.1007/s00392-016-1026-5
Genetic risk score for intracranial aneurysms to predict aneurysmal subarachnoid hemorrhage and identify associations with patient characteristics, Kamatani, Y., Woo, D., Werring, D.J., Broderick, J.P., Slowik, A., Pera, J., Worrall, B.B., Rinkel, G.J.E., Debette, S., Tatlisumak, T., Sargurupremraj, M., Dichgans, M., Malik, R., Walters, R.G., Bourcier, R., Palotie, A., Nyholt, D.R., Chasman, D.I., Olesen, J., Neale, B.M., Daly, M.J., Eriksson, N., Stefansson, K., Smith, G.D., Boomsma, D.I., Zwart, J.-A., van den Maagdenberg, A.M.J.M., Wessman, M., Dichgans, M., Belin, A.C., Ferrari, M.D., Strachan, D.P., Kubisch, C., Metspalu, A., Järvelin, M.-R., Spector, T., Ikram, M.A., Raitakari, O., Aromaa, A.J., Kaprio, J., Werge, T., Hansen, T.F., Christensen, A.F., Esserlind, A.-L., Göbel, H., Milani, L., Mihailov, E., Männikkö, M., Nielsen, C.S., Stubhaug, A., Pedersen, L.M., Cherkas, L., van Duijn, C.M., Hofman, A., Uitterlinden, A.G., Loehrer, E., Heikkilä, K., Salomaa, V., Eriksson, J.G., Meitinger, T., Schreiber, S., Muller-Myhsok, B., Cader, Z., Webber, C., Sandor, C., Lee, P.H., Stergiakouli, E., Huang, J., Franke, L., Byrnes, A.E., Huang, H., Hämäläinen, E., Pärn, K., Mägi, R., Kals, M., Kurki, M.I., Montgomery, G.W., Martin, N.G., Madden, P.A.F., Heath, A.C., Malik, R., Vepsäläinen, S., Kaunisto, M., Artto, V., Färkkilä, M., Hottenga, J.-J., Ring, S.M., Stefansson, H., Hrafnsdottir, M.G., Ridker, P.M., Schürks, M., Buring, J.E., Hinds, D.A., Wedenoja, J., Sarin, A.-P., Lehtimäki, T., Adams, H.H.H., Quaye, L., Koiranen, M., Borck, G., Steinberg, S., Stam, A.H., Gordon, S.G., Ran, C., Freilinger, T.M., Kallela, M., Terwindt, G.M., Ligthart, L., McMahon, G., Ingason, A., Kurth, T., Furlotte, N.A., Muona, M., Cuenca-Leon, E., Farh, K.-H., Pers, T.H., Esko, T., Palta, P., Winsvold, B.S., Anttila, V., Gormley, P., Caulfield, M.J., Elliott, P., Wain, L.V., Psaty, B.M., Metspalu, A., Brown, M.J., Newton-Cheh, C., Munroe, P.B., Levy, D., Zeggini, E., Wareham, N.J., van der 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Enhancer promoter interactome and Mendelian randomization identify network of druggable vascular genes in coronary artery disease, Mathieu, P., Thériault, S., Arsenault, B.J., Bossé, Y., Voisine, P., Argaud, D., Rufiange, A., Mathieu, S., Chignon, A., Human Genomics, 2022, 10.1186/s40246-022-00381-4
Lipoprotein Proteomics and Aortic Valve Transcriptomics Identify Biological Pathways Linking Lipoprotein(a) Levels to Aortic Stenosis, Benoit Arsenault, Yohan Bossé, Patrick Mathieu, Sébastien Thériault, Arnaud Droit, Philippe Pibarot, Marlys L. Koschinsky, Michael B. Boffa, Nathalie Gaudreault, Corey A. Scipione, Sylvie Bourassa, Clarisse Gotti, Patricia L. Mitchell, Arnaud Girard, Jakie Guertin, Nicolas Perrot, Audrey-Anne Despres, Jérôme Bourgault, Raphaëlle Bourgeois, Metabolites, 2021, 10.3390/metabo11070459
Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction, Munroe, P.B., Lubitz, S.A., Jamshidi, Y., Ellinor, P.T., Stefansson, K., Tinker, A., Benjamin, E.J., Thorsteinsdottir, U., Thorolfsdottir, R.B., Thorleifsson, G., Sulem, P., Holm, H., Gudbjartsson, D.F., Arnar, D.O., van Duijvenboden, S., Ramirez, J., Orini, M., Lambiase, P.D., Yldau van der Ende, M., Abdullah Said, M., Stilp, A., Assa, S., Seyerle, A.A., Laurie, C.C., Kerr, K.F., Gogarten, S.M., Avery, C.L., Soliman, E.Z., Ehret, G.B., Boerwinkle, E., Arking, D.E., Alonso, A., Whitsel, E.A., Reiner, A.P., Peters, U., Kooperberg, C., Jackson, R.D., Haessler, J., van den Berg, M.E., Uitterlinden, A., Stricker, B.H., Smith, B.H., Porteous, D.J., Murray, A.D., Lunetta, K.L., Newton-Cheh, C.H., Lin, H., Levy, D., Tarasov, K.V., Qian, Y., Lakatta, E.G., Ding, J., Cucca, F., Noordam, R., Mook-Kanamori, D.O., Maan, A.C., de Mutsert, R., Yao, J., Taylor, K.D., Rotter, J.I., Lin, H.J., Heckbert, S.R., Guo, X., Salomaa, V., Sääksjärvi, K., Jula, A., Havulinna, A.S., Weiss, S., Völker, U., Felix, S.B., Dörr, M., Trompet, S., Macfarlane, P.W., Ford, I., Wouter Jukema, J., Pramstaller, P.P., Pattaro, C., Fuchsberger, C., de Grandi, A., Sotoodehnia, N., Rice, K., Psaty, B.M., Brody, J.A., Bis, J.C., Biggs, M.L., Gustav Smith, J., Benjamin Shoemaker, M., Roden, D.M., London, B., Olesen, M., Fatkin, D., Cutler, M.J., Strauch, K., Sinner, M.F., Kääb, S., Schramm, K., Verweij, N., van der Harst, P., van de Vegte, Y.J., Rienstra, M., Spector, T.D., Mangino, M., Waldenberger, M., Peters, A., Müller-Nurasyid, M., Meitinger, T., Wilson, J., Mei, H., Correa, A., Preuss, M.H., Nadkarni, G.N., Loos, R.J.F., Bottinger, E.P., Smith, A.V., Launer, L.J., Harris, T.B., Gudnason, V., Huang, P.L., van Duijn, C.M., Kors, J.A., Isaacs, A., Wilson, J.F., Joshi, P.K., Campbell, H., Barnes, C.L.K., Raitakari, O.T., Lyytikäinen, L.-P., Lehtimäki, T., Hutri-Kähönen, N., Thériault, S., Risch, L., Conen, D., Aeschbacher, S., Shuldiner, A.R., Ryan, K., O'Connell, J.R., Montasser, M.E., Padmanabhan, S., Dominiczak, A., Caulfield, M.J., Nikus, K., Mononen, N., Mishra, P.P., Kähönen, M., Ulivi, S., Sinagra, G., Samani, N.J., Riaz, M.B., Nelson, C.P., Sundström, J., Lindgren, C.M., Lind, L., Cook, J.P., Hicks, A.A., Gögele, M., Foco, L., Fabiola Del Greco, M., Morris, A.P., Mahajan, A., Ingelsson, E., Giedraitis, V., Tarazona-Santos, E., Souza, R.P., Ribeiro, A.L.P., Lima-Costa, M.F., Araujo, N.M., Rudan, I., Polasek, O., Kolcic, I., Boutin, T., Gasparini, P., Concas, M.P., Cranley, J.J., Marten, J., Hayward, C., Warren, H.R., Mifsud, B., Barnes, M.R., Roselli, C., Chaffin, M.D., Choi, S.H., Tucker, N.R., Sveinbjornsson, G., Hall, A.W., Cartwright, J.H., Weng, L.-C., Ntalla, I., bioRxiv, 2019, 10.1101/712398
Association of FADS1/2 Locus Variants and Polyunsaturated Fatty Acids with Aortic Stenosis, Thanassoulis, G., Engert, J.C., Lathrop, M., Rader, D.J., Smith, J.G., Wells, Q.S., Bossé, Y., Söderberg, S., Clarke, R., Post, W.S., Tsai, M.Y., Rotter, J.I., O'Donnell, C.J., Gudnason, V., Mathieu, P., Arsenault, B.J., Pibarot, P., Wareham, N.J., Boekholdt, S.M., Stark, K.D., Damrauer, S.M., Harris, W.S., Larson, M.G., Vasan, R.S., Nguyen, A., Budoff, M.J., Whitmer, R.A., Ranatunga, D.K., Johansson, B., Näslund, U., Ljungberg, J., Dufresne, L., Sonestedt, E., Rong, J., Shaffer, C.M., Levinson, R.T., Zhang, R., Steffen, B., Munter, H.M., Thériault, S., Martinsson, A., Ambikkumar, A., Burr, H.A., Small, A.M., Cairns, B.J., Chen, H.Y., JAMA Cardiology, 2020, 10.1001/jamacardio.2020.0246
A transcriptome-wide association study identifies PALMD as a susceptibility gene for calcific aortic valve stenosis, Bossé, Y., Mathieu, P., Pibarot, P., Dagenais, F., Capoulade, R., Clavel, M.-A., Messika-Zeitoun, D., Lamontagne, M., Gaudreault, N., Thériault, S., bioRxiv, 2017, 10.1101/184945
Impact of the gut microbiota and associated metabolites on cardiometabolic traits, chronic diseases and human longevity: a Mendelian randomization study, Benoit J. Arsenault, Patrick Mathieu, Sébastien Thériault, Nooshin Ghodsian, Tõnu Esko, Nele Taba, Erik Abner, Hasanga D. Manikpurage, Patricia L. Mitchell, Eloi Gagnon, Journal of Translational Medicine, 2023, 10.1186/s12967-022-03799-5
Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways, Munroe, P.B., Newton-Cheh, C., Mifsud, B., Sotoodehnia, N., Lambiase, P.D., Ramirez, J., Arking, D.E., Wilson, J.F., Verweij, N., van Duijn, C.M., van der Harst, P., Stricker, B., Rotter, J.I., Psaty, B.M., Peters, A., Pattaro, C., Padmanabhan, S., Orini, M., Olesen, M.S., O’Connell, J.R., Morris, A.P., Mook-Kanamori, D.O., Lubitz, S.A., Loos, R.J.F., Liu, Y., Lima-Costa, M.F., Lehtimäki, T., Kooperberg, C., Kanters, J.K., Kähönen, M., Kääb, S., Jukema, J.W., Järvelin, M.-R., Jamshidi, Y., Hayward, C., Grarup, N., Girotto, G., Gharib, S.A., Dörr, M., Cucca, F., Correa, A., Conen, D., Avery, C.L., Wilson, J.G., Whitsel, E.A., Weng, L.-C., Waldenberger, M., Völzke, H., Völker, U., Uitterlinden, A., Trompet, S., Tinker, A., Taylor, K.D., Tarasov, K., Strauch, K., Stoll, M., Soliman, E.Z., Sinner, M.F., Sinagra, G., Shoemaker, M.B., Shen, X., Schurmann, C., Schotten, U., Schlessinger, D., Risch, L., Rice, K.M., Ribeiro, A.L.P., Reiner, A.P., Raitakari, O.T., Preuss, M.H., Pramstaller, P.P., Porteous, D.J., Pittman, A., Pelliccione, G., Patton, K.K., Pare, G., Nikus, K., Navarro, P., Nauffal, V., Nauck, M., Morrison, A.C., Montasser, M.E., Mononen, N., Mitchell, R.N., Mishra, P.P., Mezzavilla, M., Meitinger, T., Mangino, M., MacFarlane, P.W., Liu, S., Linneberg, A., Lind, L., Lin, H.J., Lemaitre, R.N., Leal, T.P., Kors, J.A., Kavousi, M., Junttila, J., Jackson, R.D., Ikram, M.A., Hutri-Kähönen, N., Huikuri, H.V., Huang, P.L., Heckbert, S.R., Hansen, T., Guo, X., Graff, M., Graff, C., Gögele, M., Fuchsberger, C., Froguel, P., Felix, S.B., Ellinor, P.T., Ellervik, C., Ding, J., De Luca, A., De Grandi, A., Darbar, D., Cutler, M.J., Cocca, M., Catamo, E., Campbell, A., Boerwinkle, E., Bis, J.C., Andreasen, L., Alonso, A., Ahlberg, G., Aeschbacher, S., Raza, D., Yao, J., Warren, H.R., van Duijvenboden, S., Thériault, S., Tarazona-Santos, E., Ryan, K.A., Roselli, C., Richmond, A., Qian, Y., Nursyifa, C., Müller-Nurasyid, M., Moscati, A., Mei, H., Lin, H., Isaksen, J.L., Hines, O., Freudling, R., Evans, D.S., Cook, J.P., Bartz, T.M., Baldassari, A.R., Weiss, S., van den Berg, M.E., Concas, M.P., Repetto, L., Lyytikäinen, L.-P., Haessler, J., Benjamins, J.-W., Noordam, R., Salman, R., Brody, J.A., Ahmed, F., Foco, L., Duong, T.V., Isaacs, A., Lahrouchi, N., Young, W.J., Nature Communications, 2022, 10.1038/s41467-022-32821-z
A trans-omic Mendelian randomization study of parental lifespan uncovers novel aging biology and therapeutic candidates for chronic diseases, Arsenault, B.J., Mathieu, P., Thériault, S., Bossé, Y., Ghodsian, N., Mitchell, P.L., Li, Z., Couture, C., Bourgault, J., Pelletier, W., Perrot, N., Aging Cell, 2021, 10.1111/acel.13497
Integrative Analysis of the Blood Proteome by Mendelian Randomization Reveals Regulatory Networks in Calcific Aortic Valve Disease, Patrick Mathieu, Yohan Bossé, Benoit Arsenault, Sébastien Thériault, Anne Rufiange, Samuel Mathieu, Valentine Duclos, Louis-Hippolyte Minvielle Moncla, Mewen Briend, 2023, 10.1101/2023.07.26.23293222
Erratum to: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits (Nature Genetics, (2018), 50, 10, (1412-1425), 10.1038/s41588-018-0205-x), Caulfield, M.J., Elliott, P., Wain, L.V., Barnes, M.R., Tzoulaki, I., Psaty, B.M., Edwards, T.L., O’Donnell, C.J., Hung, A.M., Metspalu, A., Brown, M.J., Newton-Cheh, C., Munroe, P.B., Levy, D., Zeggini, E., Wareham, N.J., van der Harst, P., Spector, T.D., Sever, P., Scott, R.J., Scott, R.A., Risch, L., Palmer, C.N.A., Mook-Kanamori, D.O., Melander, O., Langenberg, C., Lakatta, E.G., Laakso, M., Howson, J.M.M., Hayward, C., Danesh, J., Cucca, F., Conen, D., Chasman, D.I., Butterworth, A.S., Attia, J.R., Zhang, W., Zemunik, T., Yao, J., Wright, A.F., Wilson, J.F., Willemsen, G., Wild, S.H., Watkins, H., Vuckovic, D., Vollenweider, P., Völker, U., Vitart, V., Verwoert, G.C., Vergnaud, A.-C., van Duijn, C.M., van der Most, P.J., Vaez, A., Uitterlinden, A.G., Tzourio, C., Tuomilehto, J., Trompet, S., Traglia, M., Toniolo, D., Tomaszewski, M., Tobin, M.D., Teumer, A., Taylor, K.D., Swertz, M.A., Sundström, J., Strawbridge, R.J., Strachan, D.P., Stott, D.J., Starr, J.M., Sorice, R., Sõber, S., Snieder, H., Smith, A.V., Siscovick, D., Shrine, N., Schmidt, H., Schmidt, R., Sarin, A.-P., Salomaa, V., Samani, N.J., Sala, C.F., Saba, Y., Ruggiero, D., Rudan, I., Rotter, J.I., Rose, L.M., Robino, A., Ripatti, S., Riese, H., Ried, J.S., Ridker, P.M., Rice, K., Rettig, R., Ren, M., Raitakari, O.T., Nguyen, Q.T., Pramstaller, P.P., Polasek, O., Peters, A., Perola, M., Penninx, B.W.J.H., Pattie, A., Palotie, A., Palmas, W., Padmanabhan, S., Org, E., O’Reilly, P.F., Oostra, B.A., Oldehinkel, A.J., Nutile, T., Nolte, I.M., Niiranen, T., Nelson, C.P., Nandakumar, P., Nalls, M.A., Munson, P.J., Morrison, A.C., Morris, A.P., Morgan, A., Milaneschi, Y., Marten, J., Marrugat, J., Mamasoula, C., Mahajan, A., Lyytikäinen, L.-P., Lu, Y., Lopez, L.M., Loos, R.J.F., Liu, Y.M., Lindgren, C.M., Lind, L., Lin, L., Liewald, D.C.M., Lehtimäki, T., Lehne, B., Launer, L.J., Larson, M., Laan, M., Kutalik, Z., Kristiansson, K., Koskinen, S., Kooner, J.S., Kolcic, I., Knight, J., Knekt, P., Khaw, K.-T., Keavney, B.D., Kathiresan, S., Kähönen, M., Jula, A., Jukema, J.W., Jousilahti, P., Joshi, P.K., Johnson, A.D., Johansson, Å., Joehanes, R., Jarvelin, M.-R., Jansen, R., James, A., Ingelsson, E., Hwang, S.-J., Huffman, J.E., Hottenga, J.-J., Hofman, A., Hofer, E., Hicks, A.A., Havulinna, A.S., Hartman, C.A., Harris, S.E., Harris, T.B., Hamsten, A., Gyllensten, U., Guo, X., Gudnason, V., Gow, A.J., Goel, A., Girotto, G., Gieger, C., Giedraitis, V., Gasparini, P., Gandin, I., Franco, O.H., Frånberg, M., Ferreira, T., Erzurumluoglu, A.M., Enroth, S., Elosua, R., Ehret, G.B., Dörr, M., Demirkale, C.Y., Del Greco M, F., Deelen, J., Deary, I.J., de Geus, E.J., de Borst, M.H., Davies, G., Cordell, H.J., Collins, F., Cocca, M., Ciullo, M., Chauhan, G., Chambers, J.C., Chakravarti, A., Campbell, H., Campbell, A., Brumat, M., Braund, P.S., Bottinger, E.P., Boomsma, D.I., Boerwinkle, E., Boehnke, M., Bochud, M., Blake, T., Bis, J.C., Batini, C., Barbieri, C.M., Ayers, K.L., Arking, D.E., Amin, N., Abecasis, G., Thom, S., Stanton, A., Shields, D.C., Poulter, N.R., Paré, G., Noordam, R., Morris, A.D., Menni, C., Farrall, M., Doney, A.S.F., de Mutsert, R., Connell, J., Amouyel, P., Zhao, J.-H., Willems, S.M., Verweij, N., Thériault, S., Surendran, P., Shah, N., Sargurupremraj, M., Qian, Y., Prins, B.P., Oldmeadow, C., Mangino, M., Luan, J., Lin, W.-Y., Li-Gao, R., Jackson, A.U., Holliday, E.G., Giulianini, F., Ding, J., Debette, S., Boutin, T., Almgren, P., Milani, L., Mägi, R., Esko, T., Kovesdy, C.P., Tsao, P.S., Wilson, P.W.F., Gaziano, J.M., Cho, K., Sun, Y.V., Velez Edwards, D.R., Giri, A., Hellwege, J.N., Tzanis, E., Witkowska, K., Evangelou, M., Ng, F.L., Karaman, I., Cabrera, C.P., Dimou, N., Ntritsos, G., Gao, H., Pazoki, R., Mifsud, B., Mosen-Ansorena, D., Warren, H.R., Evangelou, E., Nature Genetics, 2018, 10.1038/s41588-018-0297-3
Lipoprotein(a), Oxidized Phospholipids, and Aortic Valve Microcalcification Assessed by 18F-Sodium Fluoride Positron Emission Tomography and Computed Tomography, Arsenault, B.J., Clavel, M.-A., Pibarot, P., Thanassoulis, G., Tsimikas, S., Dweck, M.R., Mathieu, P., Couture, P., Witztum, J.L., Bossé, Y., Thériault, S., Engert, J.C., Nadeau, M., Guimond, J., Tessier, M., Trottier, M., Bourgeois, R., Chen, H.Y., Shen, M., Tastet, L., Poulin, A., Perrot, N., Després, A.-A., CJC Open, 2019, 10.1016/j.cjco.2019.03.004
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits, Caulfield, M.J., Elliott, P., Wain, L.V., Barnes, M.R., Tzoulaki, I., Psaty, B.M., Edwards, T.L., O’Donnell, C.J., Hung, A.M., Metspalu, A., Brown, M.J., Newton-Cheh, C., Munroe, P.B., Levy, D., Zeggini, E., Wareham, N.J., van der Harst, P., Spector, T.D., Sever, P., Scott, R.J., Scott, R.A., Risch, L., Palmer, C.N.A., Mook-Kanamori, D.O., Melander, O., Langenberg, C., Lakatta, E.G., Laakso, M., Howson, J.M.M., Hayward, C., Danesh, J., Cucca, F., Conen, D., Chasman, D.I., Butterworth, A.S., Attia, J.R., Zhang, W., Zemunik, T., Yao, J., Wright, A.F., Wilson, J.F., Willemsen, G., Wild, S.H., Watkins, H., Vuckovic, D., Vollenweider, P., Völker, U., Vitart, V., Verwoert, G.C., Vergnaud, A.-C., van Duijn, C.M., van der Most, P.J., Vaez, A., Uitterlinden, A.G., Tzourio, C., Tuomilehto, J., Trompet, S., Traglia, M., Toniolo, D., Tomaszewski, M., Tobin, M.D., Teumer, A., Taylor, K.D., Swertz, M.A., Sundström, J., Strawbridge, R.J., Strachan, D.P., Stott, D.J., Starr, J.M., Sorice, R., Sõber, S., Snieder, H., Smith, A.V., Siscovick, D., Shrine, N., Schmidt, H., Schmidt, R., Sarin, A.-P., Samani, N.J., Salomaa, V., Sala, C.F., Saba, Y., Ruggiero, D., Rudan, I., Rotter, J.I., Rose, L.M., Robino, A., Ripatti, S., Riese, H., Ried, J.S., Ridker, P.M., Rice, K., Rettig, R., Ren, M., Raitakari, O.T., Nguyen, Q.T., Pramstaller, P.P., Polasek, O., Peters, A., Perola, M., Penninx, B.W.J.H., Pattie, A., Palotie, A., Palmas, W., Padmanabhan, S., Org, E., O’Reilly, P.F., Oostra, B.A., Oldehinkel, A.J., Nutile, T., Nolte, I.M., Niiranen, T., Nelson, C.P., Nandakumar, P., Nalls, M.A., Munson, P.J., Morrison, A.C., Morris, A.P., Morgan, A., Milaneschi, Y., Marten, J., Marrugat, J., Mamasoula, C., Mahajan, A., Lyytikäinen, L.-P., Lu, Y., Lopez, L.M., Loos, R.J.F., Liu, Y.M., Lindgren, C.M., Lind, L., Lin, L., Liewald, D.C.M., Lehtimäki, T., Lehne, B., Launer, L.J., Larson, M., Laan, M., Kutalik, Z., Kristiansson, K., Koskinen, S., Kooner, J.S., Kolcic, I., Knight, J., Knekt, P., Khaw, K.-T., Keavney, B.D., Kathiresan, S., Kähönen, M., Jula, A., Jukema, J.W., Jousilahti, P., Joshi, P.K., Johnson, A.D., Johansson, Å., Joehanes, R., Jarvelin, M.-R., Jansen, R., James, A., Ingelsson, E., Hwang, S.-J., Huffman, J.E., Hottenga, J.-J., Hofman, A., Hofer, E., Hicks, A.A., Havulinna, A.S., Hartman, C.A., Harris, S.E., Harris, T.B., Hamsten, A., Gyllensten, U., Guo, X., Gudnason, V., Gow, A.J., Goel, A., Girotto, G., Gieger, C., Giedraitis, V., Gasparini, P., Gandin, I., Franco, O.H., Frånberg, M., Ferreira, T., Erzurumluoglu, A.M., Enroth, S., Elosua, R., Ehret, G.B., Dörr, M., Demirkale, C.Y., Del Greco M, F., Deelen, J., Deary, I.J., Borst, M.H., Geus, E.J., Davies, G., Cordell, H.J., Collins, F., Cocca, M., Ciullo, M., Chauhan, G., Chambers, J.C., Chakravarti, A., Campbell, H., Campbell, A., Brumat, M., Braund, P.S., Bottinger, E.P., Boomsma, D.I., Boerwinkle, E., Boehnke, M., Bochud, M., Blake, T., Bis, J.C., Batini, C., Barbieri, C.M., Ayers, K.L., Amin, N., Arking, D.E., Abecasis, G., Thom, S., Stanton, A., Shields, D.C., Poulter, N.R., Paré, G., Noordam, R., Morris, A.D., Menni, C., Farrall, M., Doney, A.S.F., de Mutsert, R., Connell, J., Amouyel, P., Zhao, J.-H., Willems, S.M., Verweij, N., Thériault, S., Surendran, P., Shah, N., Sargurupremraj, M., Qian, Y., Prins, B.P., Oldmeadow, C., Mangino, M., Luan, J., Lin, W.-Y., Li-Gao, R., Jackson, A.U., Holliday, E.G., Giulianini, F., Ding, J., Debette, S., Boutin, T., Almgren, P., Milani, L., Mägi, R., Esko, T., Kovesdy, C.P., Tsao, P.S., Wilson, P.W.F., Gaziano, J.M., Cho, K., Sun, Y.V., Velez Edwards, D.R., Giri, A., Hellwege, J.N., Tzanis, E., Witkowska, K., Evangelou, M., Ng, F.L., Karaman, I., Cabrera, C.P., Dimou, N., Ntritsos, G., Gao, H., Pazoki, R., Mifsud, B., Mosen-Ansorena, D., Warren, H.R., Evangelou, E., Nature Genetics, 2018, 10.1038/s41588-018-0205-x
A Multivariable Mendelian Randomization Analysis Disentangling The Causal Relations Between Abdominal Obesity, Non-Alcoholic Fatty Liver Disease and Cardiometabolic Diseases, Arsenault, B., Thériault, S., Tchernof, A., Vohl, M.-C., Després, J.-P., Ghodsian, N., Mitchell, P., Esko, T., Taba, N., Abner, E., Maltais-Payette, I., Manikpurage, H., Bourgault, J., Gobeil, É., Pelletier, W., Gagnon, E., ResearchSquare, 2022, 10.21203/rs.3.rs-1336425
PALMD as a novel target for calcific aortic valve stenosis, Thériault, S., Mathieu, P., Bossé, Y., Current Opinion in Cardiology, 2019, 10.1097/HCO.0000000000000605
Variability of High-Sensitivity Troponin T Concentrations in Emergency Settings, Thériault, S., Douville, P., American Journal of Clinical Pathology, 2018, 10.1093/ajcp/aqy025
Mendelian randomization of circulating proteome identifies actionable targets in heart failure, Mathieu, P., Arsenault, B.J., Thériault, S., Bossé, Y., Sylla, M.S., Mathieu, S., Moncla, L.-H.M., BMC Genomics, 2022, 10.1186/s12864-022-08811-2
Elevated Lipoprotein(a) and Risk of Atrial Fibrillation: An Observational and Mendelian Randomization Study, Paré, G., Pigeyre, M., Lanktree, M.B., Bossé, Y., Thériault, S., Roberts, J.D., Conen, D., Perrot, N., Narula, S., Chong, M., Mohammadi-Shemirani, P., Journal of the American College of Cardiology, 2022, 10.1016/j.jacc.2022.02.018
Atrial fibrillation genetic risk differentiates cardioembolic stroke from other strokel subtypes, Sheth, K., Lee, J.-M., Heitsch, L., Bushnell, C., Langefeld, C., Fernandez-Cadenas, I., Montaner, J., Spence, D., Longstreth, W., Tirschwell, D., Bennett, S., Keene, K., Cushman, M., Majersik, J., Fornage, M., Giese, A.-K., Farrall, M., Attia, J., Maguire, J., Kalaria, R., Holliday, E., Brown, D., Brown, R., Chang, Y.-C., Dobbins, M., Chang, C., Nakagawa, K., Pedersen, A., Walters, M., McDonough, C., Silliman, S., Rannikmae, K., Sudlow, C., Doney, A., Kissela, B., Broderick, J., Saleheen, D., Fisher, M., Cramer, S., Padovani, A., Pezzini, A., Arnett, D., Perry, R., Macleod, M., Algra, A., van't Hof, F., Klijn, K., Thijs, V., Martin, J.J., Smith, G., Norrving, B., Hansen, B., Lindgren, A., Smalley, J., Sofat, R., Werring, D., Karaszewski, B., Stine, C., Illoh, K., Milewicz, D., O'Connell, J., Cole, J., Woo, D., Howard, G., Lam, O., Jain, V., Taqi, M., Giraldo, E., Chern, J., Sheu, W., Chiou, H.Y., Bevan, S., Peycke, J., Markus, H., Kilarski, L., Lee, C., Kim, H., Olsson, S., Jood, K., Jern, C., Lebedeva, E., Mok, V., Schilling, S., Rothwell, P., Olugbodi, A., Tan, E.K., Lee, W.L., Le, K.E., Waddy, S., Chen, C., Singleton, A., Corriveau, R., Barr, T., Gwinn, K., Deng, Z., Gschwendtner, A., Chan, Y.-F.Y., Sacco, R., Rundek, T., Bersano, A., Yamada, Y., Blanton, S., Seiler, S., Schmidt, R., Schmidt, H., Enzinger, C., Pichler, A., Brott, T., Meschia, J., Mueller-Myhsok, B., Battey, T., Kourkoulis, C., Du, R., Brouwers, B., Falcone, G., Anderson, C., Biffi, A., Romero, J., Sadr-Nabavi, A., Burri, P., Staals, J., Gonik, M., Duering, M., Opherk, C., Ahmadi, K., Lemmens, R., Kostulas, K., Keller, L., Crisby, M., Goncalves, A., Franca, P., Cabral, N., Cendes, I., Nyquist, P., Levi, C., Juchniewicz, K.J., Slowik, A., Pera, J., Olszanecki, R., Wnuk, M., Gasowski, J., Jagiella, J., Dziedzic, T., Urbanik, A., Mateusz, A., Parati, E., Ballabio, E., Boncoraglio, G., Korostynski, M., Hardy, J., Cotlarcius, I., Jimenez-Conde, J., Roquer, J., Giralt, E., Soriano, C., Bijlenga, P., Happola, O., Tatlisumak, T., Rich, S., Sharma, P., Olesen, J., Kidwell, C., Carty, C., Leys, D., O'Donnell, C., Breteler, M., James, M.L., Goldstein, L., Elkind, M., Chang, K.-C., Lee, T.-H., Sale, M., Luke, M., Chen, I., Rexrode, K., Wolf, P., Seshadri, S., Pikula, A., Selim, M., Wang, X., Sorkin, J., Smoller, S., Lunetta, K.L., Tanaka, T., Heckbert, S.R., Chasman, D.I., Kääb, S., Roden, D.M., Alonso, A., Gudnason, V., Felix, S.B., Chung, M.K., Stricker, B.H., Lehtimäki, T., März, W., Rotter, J.I., Hayward, C., Wouter Jukema, J., Pereira, A., Kathiresan, S., Lokki, M.-L., van der Harst, P., Conen, D., Laurikka, J., Loos, R.J.F., Melander, O., Kooperberg, C., Ingelsson, E., Dichgans, M., Guo, X., Lin, H.J., Sinner, M.F., Jöckel, K.-H., Völker, U., Franco, O.H., Hofman, A., Uitterlinden, A.G., Soliman, E.Z., Sotoodehnia, N., Huang, P.L., Almgren, P., Heilmann, S., Macfarlane, P.W., Shaffer, C., Newton-Cheh, C., Darbar, D., Kriebel, J., Denny, J.C., Heeringa, J., Hamsten, A., Orho-Melander, M., Nikus, K., Pedersen, N.L., Vlachopoulou, E., Hocking, L.J., Porteous, D., Magnusson, P.K., Campbell, A., Taylor, K.D., Rost, N., Lannfelt, L., Eisele, L., Boerwinkle, E., Li, M., Sandhu, R.K., Chen, Y.-D.I., Chen, L.Y., Delgado, G., Reiner, A.P., Ford, I., Morris, A.P., Eskola, M., Huang, J., Wong, J.A., Lindgren, C.M., Hernesniemi, J., Bottinger, E.B., Lu, Y., Scott, S.A., Lind, L., Smith, B.H., Peters, A., Mansur, A.J., Risch, L., Kähönen, M., Krieger, J.E., Arendt, M., Lichtner, P., Waldenberger, M., Bartz, T.M., Haessler, J., Padmanabhan, S., Benjamin Shoemaker, M., Launer, L.J., Harris, T.B., Magnani, J.W., Ridker, P.M., Psaty, B.M., Perz, S., Bis, J.C., Van Wagoner, D.R., Smith, J.D., Kubo, M., Siland, J.E., Verweij, N., Hagemeijer, Y.P., Kamatani, Y., Paré, G., Worrall, B.B., Yang, Q., Chauhan, G., Debette, S., Hopewell, J.C., Sun, A., Shah, S., Rader, D.J., Deo, R., Clauss, S., Teumer, A., Weiss, S., Radmanesh, F., Yao, J., Thériault, S., Aeschbacher, S., Sinisalo, J., Perez, M., Horimoto, A.R.V.R., Malik, R., Seppälä, I., Lyytikäinen, L.-P., Kleber, M.E., Schurmann, C., Gustafsson, S., Huffman, J., Trompet, S., Dörr, M., Niemeijer, M.N., Brody, J.A., Gustav Smith, J., Müller-Nurasyid, M., Weeke, P.E., Low, S.-K., Bihlmeyer, N.A., Klarin, D., Li, M., Tucker, N.R., Chaffin, M., Albert, C.M., Smith, A.V., Arking, D.E., Lin, H., Barnard, J., Geelhoed, B., Yin, X., Roselli, C., Rienstra, M., Christophersen, I.E., Anderson, C.D., Lubitz, S.A., Kittner, S.J., Ellinor, P.T., Benjamin, E.J., de Bakker, P.I.W., Rosand, J., Mitchell, B.D., Choi, S.H., Trinquait, L., McArdle, P.F., Weng, L.-C., Pulit, S.L., bioRxiv, 2017, 10.1101/239269
The journey towards identification of actionable molecular pathways in calcific aortic valve stenosis, Yohan Bossé, Patrick Mathieu, Sébastien Thériault, European Heart Journal, 2023, 10.1093/eurheartj/ehad134
Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium, Lubitz, S.A., Albert, C.M., Felix, S.B., Stricker, B.H., Jukema, J.W., Van Der Harst, P., Rotter, J.I., Smith, J.G., März, W., Lehtimäki, T., Benjamin, E.J., Heckbert, S.R., Chung, M.K., Roden, D.M., Conen, D., Arking, D.E., Gudnason, V., Kääb, S., Rose, L.M., Teumer, A., Völker, U., Uitterlinden, A.G., Franco, O.H., Heeringa, J., Ford, I., Macfarlane, P., Verweij, N., Geelhoed, B., Ellinor, P.T., Christophersen, I.E., Guo, X., Yao, J., Engström, G., Melander, O., Delgado, G.E., Nikus, K., Kähönen, M., Taylor, K.D., Sotoodehnia, N., Psaty, B.M., Smith, J.D., Van Wagoner, D.R., Shoemaker, M.B., Denny, J.C., Teixeira, P.L., Paré, G., Alonso, A., Soliman, E.Z., Harris, T.B., Launer, L.J., Waldenberger, M., Sinner, M.F., Chasman, D.I., Klarin, D., Dörr, M., Krijthe, B.P., Trompet, S., Rienstra, M., Lin, H.J., Martinsson, A., Kleber, M.E., Lyytikäinen, L.-P., Bis, J.C., Barnard, J., Weeke, P.E., Thériault, S., Smith, A.V., Müller-Nurasyid, M., Lunetta, K.L., Weng, L.-C., Scientific Reports, 2017, 10.1038/s41598-017-09396-7
Absence of association between serum folate and preeclampsia in women exposed to food fortification., Forest, J.C., Bujold, E., Girouard, J., Lavoie, S.B., Massé, J., Giguère, Y., Thériault, S., Obstetrics and gynecology, 2013, 10.1097/aog.0b013e31829b2f7c
Sex-Specific Associations of Genetically Predicted Circulating Lp(a) (Lipoprotein(a)) and Hepatic LPA Gene Expression Levels With Cardiovascular Outcomes: Mendelian Randomization and Observational Analyses, Arsenault, B.J., Boekholdt, S.M., Thériault, S., Clavel, M.-A., Mathieu, P., Stroes, E.S.G., Pibarot, P., Bossé, Y., Wareham, N.J., Couture, C., Bourgeois, R., Perrot, N., Manikpurage, H., Kaiser, Y., Guertin, J., Circulation: Genomic and Precision Medicine, 2021, 10.1161/CIRCGEN.120.003271
Polygenic Risk Score for Coronary Artery Disease Improves the Prediction of Early-Onset Myocardial Infarction and Mortality in Men, Sébastien Thériault, Benoit J. Arsenault, Yohan Bossé, Patrick Mathieu, Christian Couture, Zhonglin Li, Nicolas Perrot, Aida Eslami, Hasanga D. Manikpurage, Circulation: Genomic and Precision Medicine, 2021, 10.1161/CIRCGEN.121.003452
Identification of circulating proteins associated with blood pressure using Mendelian randomization, Paré, G., Gerstein, H., Hess, S., Chong, M., Sjaarda, J., Thériault, S., Circulation: Genomic and Precision Medicine, 2020, 10.1161/CIRCGEN.119.002605
A Comparative Analysis of the Lipoprotein(a) and Low-Density Lipoprotein Proteomic Profiles Combining Mass Spectrometry and Mendelian Randomization, Arsenault, B.J., Mathieu, P., Pibarot, P., Boffa, M.B., Thériault, S., Koschinsky, M.L., Droit, A., Couture, P., Després, A.-A., Scipione, C.A., Capoulade, R., Mass, E., Poggio, P., Bourassa, S., Gotti, C., Couture, C., Mitchell, P.L., Guertin, J., Perrot, N., Girard, A., Bourgeois, R., CJC Open, 2021, 10.1016/j.cjco.2020.11.019
Mendelian Randomization of Circulating Proteome Identifies Actionable Targets in Heart Failure, Mathieu, P., Arsenault, B., Thériault, S., Bossé, Y., Mathieu, S., Moncla, L.-H.M., ResearchSquare, 2022, 10.21203/rs.3.rs-1547537
Contribution of Lipoprotein(a) to Polygenic Risk Prediction of Coronary Artery Disease: A Prospective UK Biobank Analysis, Benoit J. Arsenault, Sébastien Thériault, Patrick Mathieu, Aida Eslami, Arnaud Girard, Audrey Paulin, Hasanga D. Manikpurage, Circulation: Genomic and Precision Medicine, 2023, 10.1161/CIRCGEN.123.004137
Enhancer promoter interactome and Mendelian randomization identify network of druggable vascular genes in coronary artery ddisease, Mathieu, P., Thériault, S., Arsenault, B., Bossé, Y., Voisine, P., Argaud, D., Rufiange, A., Mathieu, S., Chignon, A., ResearchSquare, 2021, 10.21203/rs.3.rs-978033
Mendelian randomization analysis identifies blood tyrosine levels as a biomarker of non-alcoholic fatty liver disease, Arsenault, B.J., Tchernof, A., Esko, T., Thériault, S., Vohl, M.-C., Corbeil, J., Julien, F., Mathieu, P., Mitchell, P.L., Couture, C., Manikpurage, H.D., Gagnon, É., Bourgault, J., Abner, E., Ghodsian, N., Brière, F., Taba, N., Maltais-Payette, I., Gobeil, É., medRxiv, 2021, 10.1101/2021.11.26.21266879
Soluble Fms-like tyrosine kinase-1 to placental growth factor ratio in mid-pregnancy as a predictor of preterm preeclampsia in asymptomatic pregnant women, Giguère, Y., Bujold, E., Massé, J., Thériault, S., Forest, J.-C., Clinical Chemistry and Laboratory Medicine, 2014, 10.1515/cclm-2013-0955
Genetic Variation in LPA, Calcific Aortic Valve Stenosis in Patients Undergoing Cardiac Surgery, and Familial Risk of Aortic Valve Microcalcification, Arsenault, B.J., Bossé, Y., Clavel, M.-A., Thanassoulis, G., Schott, J.-J., Pibarot, P., Mathieu, P., Dweck, M.R., Wareham, N.J., Khaw, K.-T., Engert, J.C., Nadeau, M., Guimond, J., Tessier, M., Trottier, M., Messika-Zeitoun, D., Le Tourneau, T., Capoulade, R., Poulin, A., Després, A.-A., Rigade, S., Boekholdt, S.M., Chen, H.Y., Dina, C., Thériault, S., Perrot, N., JAMA Cardiology, 2019, 10.1001/jamacardio.2019.1581
Genetic analyses of the QT interval and its components in over 250K individuals identifies new loci and pathways affecting ventricular depolarization and repolarization, Munroe, P.B., Newton-Cheh, C., Mifsud, B., Sotoodehnia, N., Lambiase, P.D., Ramirez, J., Arking, D.E., Wilson, J.F., Verweij, N., van Duijn, C.M., van der Harst, P., Stricker, B., Rotter, J.I., Psaty, B.M., Peters, A., Pattaro, C., Padmanabhan, S., Orini, M., Olesen, M.S., O'Connell, J.R., Morris, A.P., Mook-Kanamori, D.O., Lubitz, S.A., Loos, R.J.F., Liu, Y., Lima-Costa, M.F., Lehtimäki, T., Kooperberg, C., Kanters, J.K., Kähönen, M., Kääb, S., Jukema, J.W., Järvelin, M.-R., Jamshidi, Y., Hayward, C., Grarup, N., Girotto, G., Gharib, S.A., Dörr, M., Cucca, F., Correa, A., Conen, D., Avery, C.L., Wilson, J.G., Whitsel, E.A., Weng, L.-C., Waldenberger, M., Völzke, H., Völker, U., Uitterlinden, A., Trompet, S., Tinker, A., Taylor, K.D., Tarasov, K., Strauch, K., Stoll, M., Soliman, E.Z., Sinner, M.F., Sinagra, G., Shoemaker, M.B., Shen, X., Schurmann, C., Schotten, U., Schlessinger, D., Risch, L., Rice, K.M., Ribeiro, A.L.P., Reiner, A.P., Raitakari, O.T., Preuss, M.H., Pramstaller, P.P., Porteous, D.J., Pittman, A., Pelliccione, G., Patton, K.K., Pare, G., Nikus, K., Navarro, P., Nauffal, V., Nauck, M., Morrison, A.C., Montasser, M.E., Mononen, N., Mitchell, R.N., Mishra, P.P., Mezzavilla, M., Meitinger, T., Mangino, M., Liu, S., MacFarlane, P.W., Linneberg, A., Lind, L., Lin, H.J., Lemaitre, R.N., Leal, T.P., Kors, J.A., Kavousi, M., Junttila, J., Jackson, R.D., Ikram, M.A., Hutri-Kähönen, N., Huikuri, H.V., Huang, P.L., Heckbert, S.R., Hansen, T., Guo, X., Graff, M., Graff, C., Gögele, M., Fuchsberger, C., Froguel, P., Felix, S.B., Ellinor, P.T., Ellervik, C., Ding, J., de Luca, A., de Grandi, A., Darbar, D., Cutler, M.J., Cocca, M., Catamo, E., Campbell, A., Boerwinkle, E., Bis, J.C., Andreasen, L., Alonso, A., Ahlberg, G., Aeschbacher, S., Raza, D., Yao, J., Warren, H.R., van Duijvenboden, S., Thériault, S., Tarazona-Santos, E., Ryan, K.A., Roselli, C., Richmond, A., Qian, Y., Nursyifa, C., Müller-Nurasyid, M., Moscati, A., Mei, H., Lin, H., Isaksen, J.L., Hines, O., Freudling, R., Evans, D.S., Cook, J.P., Bartz, T.M., Baldassari, A.R., Weiss, S., van den Berg, M.E., Concas, M.P., Repetto, L., Lyytikäinen, L.-P., Haessler, J., Benjamins, J.-W., Noordam, R., Salman, R., Brody, J.A., Ahmed, F., Foco, L., Duong, T., Isaacs, A., Lahrouchi, N., Young, W.J., medRxiv, 2021, 10.1101/2021.11.04.21265866
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Mendelian Randomization Analysis Identifies Blood Tyrosine Levels as a Biomarker of Non-Alcoholic Fatty Liver Disease, Benoit Arsenault, André Tchernof, Tõnu Esko, Sébastien Thériault, Marie-Claude Vohl, Jacques Corbeil, François Julien, Patrick Mathieu, Patricia Mitchell, Christian Couture, Hasanga Dilshan Manikpurage, Eloi Gagnon, Jérôme Bourgault, Erik Abner, Nooshin Ghodsian, Francis Brière, Nele Taba, Ina Maltais-Payette, Émilie Gobeil, Metabolites, 2022, 10.3390/metabo12050440
Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction, Munroe, P.B., Lubitz, S.A., Jamshidi, Y., Ellinor, P.T., Stefansson, K., Tinker, A., Benjamin, E.J., Thorsteinsdottir, U., Thorolfsdottir, R.B., Thorleifsson, G., Sulem, P., Holm, H., Gudbjartsson, D.F., Arnar, D.O., Van Duijvenboden, S., Ramirez, J., Orini, M., Lambiase, P.D., Yldau van der Ende, M., Abdullah Said, M., Assa, S., Stilp, A., Seyerle, A.A., Laurie, C.C., Kerr, K.F., Gogarten, S.M., Avery, C.L., Soliman, E.Z., Ehret, G.B., Boerwinkle, E., Arking, D.E., Alonso, A., Whitsel, E.A., Reiner, A.P., Peters, U., Kooperberg, C., Jackson, R.D., Haessler, J., van den Berg, M.E., Uitterlinden, A., Stricker, B.H., Smith, B.H., Porteous, D.J., Murray, A.D., Lunetta, K.L., Newton-Cheh, C.H., Lin, H., Levy, D., Tarasov, K.V., Qian, Y., Lakatta, E.G., Ding, J., Cucca, F., Noordam, R., Mook-Kanamori, D.O., Maan, A.C., de Mutsert, R., Yao, J., Taylor, K.D., Rotter, J.I., Lin, H.J., Heckbert, S.R., Guo, X., Salomaa, V., Sääksjärvi, K., Jula, A., Havulinna, A.S., Weiss, S., Völker, U., Felix, S.B., Dörr, M., Trompet, S., Macfarlane, P.W., Wouter Jukema, J., Ford, I., Pramstaller, P.P., Pattaro, C., Fuchsberger, C., De Grandi, A., Sotoodehnia, N., Rice, K., Psaty, B.M., Brody, J.A., Bis, J.C., Biggs, M.L., Gustav Smith, J., Benjamin Shoemaker, M., Roden, D.M., Olesen, M., London, B., Fatkin, D., Cutler, M.J., Strauch, K., Sinner, M.F., Schramm, K., Kääb, S., Verweij, N., van der Harst, P., van de Vegte, Y.J., Rienstra, M., Spector, T.D., Mangino, M., Waldenberger, M., Peters, A., Müller-Nurasyid, M., Meitinger, T., Wilson, J., Mei, H., Correa, A., Preuss, M.H., Nadkarni, G.N., Loos, R.J.F., Bottinger, E.P., Smith, A.V., Launer, L.J., Harris, T.B., Gudnason, V., Huang, P.L., van Duijn, C.M., Kors, J.A., Isaacs, A., Wilson, J.F., Joshi, P.K., Campbell, H., Barnes, C.L.K., Raitakari, O.T., Lyytikäinen, L.-P., Lehtimäki, T., Hutri-Kähönen, N., Thériault, S., Risch, L., Conen, D., Aeschbacher, S., Shuldiner, A.R., Ryan, K., O’Connell, J.R., Montasser, M.E., Padmanabhan, S., Dominiczak, A., Caulfield, M.J., Nikus, K., Mononen, N., Mishra, P.P., Kähönen, M., Ulivi, S., Sinagra, G., Samani, N.J., Riaz, M.B., Nelson, C.P., Sundström, J., Lindgren, C.M., Lind, L., Cook, J.P., Hicks, A.A., Gögele, M., Foco, L., Del Greco M, F., Morris, A.P., Mahajan, A., Ingelsson, E., Giedraitis, V., Tarazona-Santos, E., Souza, R.P., Ribeiro, A.L.P., Lima-Costa, M.F., Araujo, N.M., Rudan, I., Polasek, O., Kolcic, I., Boutin, T., Gasparini, P., Concas, M.P., Cranley, J.J., Marten, J., Hayward, C., Warren, H.R., Mifsud, B., Barnes, M.R., Roselli, C., Chaffin, M.D., Choi, S.H., Tucker, N.R., Sveinbjornsson, G., Hall, A.W., Cartwright, J.H., Weng, L.-C., Ntalla, I., Nature Communications, 2020, 10.1038/s41467-020-15706-x
Genetic Association Analyses Highlight IL6, ALPL, and NAV1 As 3 New Susceptibility Genes Underlying Calcific Aortic Valve Stenosis, Vol, S., Tichet, J., Rakotozafy, F., Moreau, J.G., Lantieri, O., Cailleau, M., Caces, E., Born, C., Cogneau, J., Rancière, F., Froguel, P., Bonnefond, A., Bonnet, F., Marre, M., Fumeron, F., Girault, A., Alhenc-Gelas, F., Eschwège, E., Ducimetière, P., Balkau, B., Schott, J.-J., Bossé, Y., Le Tourneau, T., Mathieu, P., Pibarot, P., Dagenais, F., Roussel, R., Probst, V., Baufreton, C., Philippe Verhoye, J., Roussel, J.-C., Fellah, I., Charpentier, E., Karakachoff, M., Bonnaud, S., Baron, E., Lecointe, S., Boureau, A.-S., Arsenault, B.J., Clavel, M.-A., Lamontagne, M., Simonet, F., Li, Z., Rigade, S., Gaudreault, N., Capoulade, R., Le Scouarnec, S., Messika-Zeitoun, D., Dina, C., Thériault, S., Schott, J.-J., Bossé, Y., Le Tourneau, T., Mathieu, P., Pibarot, P., Dagenais, F., Redon, R., Roussel, R., Probst, V., Baufreton, C., Philippe Verhoye, J., Roussel, J.-C., Fellah, I., Charpentier, E., Karakachoff, M., Bonnaud, S., Baron, E., Lecointe, S., Boureau, A.-S., Arsenault, B.J., Clavel, M.-A., Lamontagne, M., Simonet, F., Li, Z., Rigade, S., Gaudreault, N., Capoulade, R., Le Scouarnec, S., Messika-Zeitoun, D., Dina, C., Thériault, S., Circulation: Genomic and Precision Medicine, 2019, 10.1161/CIRCGEN.119.002617
Genetic assessment of efficacy and safety profiles of coagulation cascade proteins identifies Factors II and XI as actionable anticoagulant targets, Benoit J. Arsenault, Patrick Mathieu, Tõnu Esko, André Tchernof, Marie-Claude Vohl, Sébastien Thériault, Dipender Gill, Erik Abner, Jérôme Bourgault, Arnaud Girard, Eloi Gagnon, 2023, 10.1101/2023.12.05.23299567
A Mendelian randomization study of IL6 signaling in cardiovascular diseases, immune-related disorders and longevity, Mathieu, P., Thériault, S., Bossé, Y., Arsenault, B.J., Boulanger, M.-C., Li, Z., Chignon, A., Rosa, M., npj Genomic Medicine, 2019, 10.1038/s41525-019-0097-4
Polygenic Contribution in Individuals with Early-Onset Coronary Artery Disease, Paré, G., Natarajan, M.K., Velianou, J.L., Lali, R., Chong, M., Thériault, S., Circulation: Genomic and Precision Medicine, 2018, 10.1161/CIRCGEN.117.001849
Integrative genomic analyses identify candidate causal genes for calcific aortic valve stenosis involving tissue-specific regulation, Yohan Bossé, Patrick Mathieu, Tõnu Esko, Nicholas J. Wareham, S. Matthijs Boekholdt, Benoit J. Arsenault, Philippe Pibarot, Marie-Annick Clavel, François Dagenais, Manel Dahmene, Déborah Argaud, Lily Frenette, Nathalie Gaudreault, Dominique K. Boudreau, Mewen Briend, Pardis Zamani, Ursula Houessou, Hasanga D. Manikpurage, Jian’an Luan, Erik Abner, Zhonglin Li, Sébastien Thériault, Nature Communications, 2024, 10.1038/s41467-024-46639-4
Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders, Elliott, P., Schumann, G., Desrivières, S., Rothenfluh, A., Matthews, P., Bell, J.D., Tzoulaki, I., Levy, D., Wilson, J.F., Weir, D.R., Verweij, N., Spector, T.D., Scott, L.J., Samani, N.J., Rudan, I., Raitakari, O.T., Psaty, B.M., Penninx, B.W.J., Oldehinkel, A.J., Martin, N.G., Morrison, A.C., Mohlke, K.L., McIntosh, A.M., Lehtimäki, T., Lahti, J., Laakso, M., Kuusisto, J., Kühne, M., Kardia, S.L.R., Kähönen, M., Jarvelin, M.-R., Heath, A.C., Hayward, C., Hartman, C.A., der Harst, P.V., Guo, X., Grabe, H.J., Eriksson, J.G., Conen, D., Campbell, H., Boehnke, M., Blakemore, A.I., Veijola, J., Snieder, H., Rotter, J.I., Risch, L., Männikkö, M., Liu, C., Auvinen, J., Arking, D.E., Zhao, W., Yu, B., Yao, J., Wood, A., Whitfield, J.B., Vangipurapu, J., Thériault, S., Tuominen, S., Teumer, A., Stančáková, A., Smith, J.A., Ratliff, S.M., Porteous, D., Polasek, O., Perälä, M.-M., Nolte, I.M., Nelson, C.P., Milaneschi, Y., Mangino, M., Lyytikäinen, L.-P., Lind, P.A., Lemaitre, R.N., Joshi, P.K., Kentistou, K.A., Jackson, A.U., Homuth, G., Faul, J.D., Dimou, N., Clarke, T.-K., Brody, J.A., Brown, M.R., Braund, P.S., Baumeister, S.E., Bartz, T.M., Aeschbacher, S., Elliott, J., Karaman, I., Yiorkas, A.M., Koskeridis, F., Suzuki, H., Pazoki, R., Butts, A.R., Blakeley, P., Ntritsos, G., Chu, C., Gao, H., Evangelou, E., bioRxiv, 2018, 10.1101/453332
A transcriptome-wide association study identifies PALMD as a susceptibility gene for calcific aortic valve stenosis, Bossé, Y., Mathieu, P., Pibarot, P., Dagenais, F., Capoulade, R., Clavel, M.-A., Messika-Zeitoun, D., Boulanger, M.-C., Rosa, M., Lamontagne, M., Gaudreault, N., Thériault, S., Nature Communications, 2018, 10.1038/s41467-018-03260-6
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Greater adherence to the 2019 Canada’s Food Guide recommendations on healthy food choices reduces the risk of cardiovascular disease in adults: a prospective analysis of UK Biobank data, Benoît Lamarche, Benoît J Arsenault, Sébastien Thériault, Hasanga D Manikpurage, Didier Brassard, The American Journal of Clinical Nutrition, 2022, 10.1093/ajcn/nqac256
Granularity of SERPINA1 alleles by DNA sequencing in CanCOLD, Bossé, Y., Bourbeau, J., Tan, W., Maltais, F., Kirby, M., Henry, C., Li, P.Z., Thériault, S., Gaudreault, N., Gupta, N., European Respiratory Journal, 2020, 10.1183/13993003.00958-2020
Sex-specific impact of body weight on atherosclerotic cardiovascular disease incidence in individuals with and without ideal cardiovascular health, Benoit J. Arsenault, Sébastien Thériault, Jean-Pierre Després, Hasanga D. Manikpurage, Audrey Paulin, 2023, 10.1101/2023.01.16.23284627
Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank, Bossé, Y., Thériault, S., Mathieu, P., Boulet, L.-P., Laviolette, M., Côté, A., Godbout, K., Labbé, C., Hao, K., Nickle, D.C., Sin, D.D., Timens, W., van den Berge, M., Obeidat, M., Joubert, P., Gaudreault, N., Lamothe, J., Eslami, A., Bérubé, J.-C., Chignon, A., Bon-Baret, V., Li, Z., Valette, K., Communications Biology, 2021, 10.1038/s42003-021-02227-6
Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation, Ellinor, P.T., Lubitz, S.A., Lunetta, K.L., Tanaka, T., Benjamin, E.J., Heckbert, S.R., Chasman, D.I., Kääb, S., Roden, D.M., Alonso, A., Gudnason, V., Felix, S.B., Chung, M.K., Stricker, B.H., Lehtimäki, T., März, W., Rotter, J.I., Hayward, C., Jukema, J.W., Pereira, A., Kathiresan, S., Lokki, M.-L., Van Der Harst, P., Rosand, J., Conen, D., Laurikka, J., Loos, R.J.F., Melander, O., Kooperberg, C., Ingelsson, E., Dichgans, M., Guo, X., Lin, H.J., Sinner, M.F., Jöckel, K.-H., Völker, U., Franco, O.H., Hofman, A., Uitterlinden, A.G., Soliman, E.Z., Sotoodehnia, N., Huang, P.L., Almgren, P., Heilmann-Heimbach, S., Macfarlane, P.W., Shaffer, C., Newton-Cheh, C., Darbar, D., Kriebel, J., Denny, J.C., Heeringa, J., Hamsten, A., Orho-Melander, M., Nikus, K., Pedersen, N.L., Vlachopoulou, E., Hocking, L.J., Porteous, D., Magnusson, P.K., Campbell, A., Taylor, K.D., Anderson, C.D., Rost, N., Lannfelt, L., Eisele, L., Boerwinkle, E., Li, M., Sandhu, R.K., Chen, Y.-D.I., Chen, L.Y., Delgado, G., Reiner, A.P., Ford, I., Morris, A.P., Eskola, M., Huang, J., Wong, J.A., Lindgren, C.M., Hernesniemi, J., Bottinger, E.B., Lu, Y., Scott, S.A., Lind, L., Smith, B.H., Peters, A., Mansur, A.J., Risch, L., Kähönen, M., Krieger, J.E., Arendt, M., Lichtner, P., Waldenberger, M., Bartz, T.M., Haessler, J., Padmanabhan, S., Shoemaker, M.B., Launer, L.J., Harris, T.B., Magnani, J.W., Ridker, P.M., Psaty, B.M., Perz, S., Bis, J.C., Van Wagoner, D.R., Smith, J.D., Kubo, M., Siland, J.E., Verweij, N., Hagemeijer, Y.P., Kamatani, Y., Paré, G., Worrall, B.B., Yang, Q., Chauhan, G., Debette, S., Hopewell, J.C., Sun, A., Shah, S.H., Rader, D.J., Deo, R., Clauss, S., Weng, L.-C., Choi, S.H., Teumer, A., Weiss, S., Radmanesh, F., Yao, J., Thériault, S., Aeschbacher, S., Sinisalo, J., Perez, M., Horimoto, A.R.V.R., Malik, R., Seppälä, I., Lyytikäinen, L.-P., Kleber, M.E., Schurmann, C., Gustafsson, S., Huffman, J., Trompet, S., Dörr, M., Niemeijer, M.N., Brody, J.A., Smith, J.G., Müller-Nurasyid, M., Weeke, P.E., Low, S.-K., Bihlmeyer, N.A., Klarin, D., Li, M., Tucker, N.R., Chaffin, M., Albert, C.M., Smith, A.V., Arking, D.E., Lin, H., Barnard, J., Geelhoed, B., Yin, X., Roselli, C., Rienstra, M., Christophersen, I.E., Nature Genetics, 2017, 10.1038/ng.3843
Genetic association and Mendelian randomization for hypothyroidism highlight immune molecular mechanisms, Mathieu, P., Arsenault, B.J., Esko, T., Thériault, S., Bossé, Y., Li, Z., Couture, C., Abner, E., Briend, M., Mathieu, S., iScience, 2022, 10.1016/j.isci.2022.104992
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals, Edwards, T.L., Hung, A.M., O’Donnell, C.J., Susztak, K., Velez Edwards, D.R., Tsao, P.S., Wilson, P.W.F., Concato, J., Gaziano, J.M., Elliott, P., Caulfield, M.J., Newton-Cheh, C., Munroe, P.B., Howson, J.M.M., Psaty, B.M., Denny, J.C., Dedoussis, G., Herzig, K.-H., Lindgren, C., Siew, E.E., Matheny, M.E., Xu, Y., Smith, J.C., Wei, W.-Q., Timpson, N.J., Hennig, B.J., Jarvelin, M.-R., Spector, T.D., Hayward, C., Schlessinger, D., Cucca, F., van der Harst, P., Mook-Kanamori, D.O., Melander, O., Ridker, P.M., Chasman, D.I., Attia, J., Palmer, C.N.A., Conen, D., Wareham, N.J., Langenberg, C., Scott, R.A., Sever, P., Zeggini, E., Laakso, M., Poulter, N.R., Farrall, M., Amouyel, P., Kraja, A., Richardson, T.G., Sepúlveda, N., Liu, C., Lahrouchi, N., Karthikeyan, S., Cook, J.P., Surendran, P., Feofanova, E., Ntalla, I., Mangino, M., Boutin, T.S., Verweij, N., Li-Gao, R., Almgren, P., Oldmeadow, C., Shah, N., Thériault, S., Willems, S.M., Zhao, J.-H., Luan, J., Scott, L.J., Boehnke, M., Debette, S., Sargurupremraj, M., Akwo, E.A., Mautz, B.S., Shrestha, R., Wain, L.V., Cabrera, C.P., Evangelou, E., Wang, Y., Cho, K., Klarin, D., DuVall, S.L., Damrauer, S.M., Birdwell, K.A., Chung, C.P., Roumie, C.L., Robinson-Cohen, C., Wilson, O.D., Sun, Y.V., Kovesdy, C.P., Torstenson, E.S., Warren, H.R., Qiu, C., Park, J., Keaton, J.M., Giri, A., Hellwege, J.N., Nature Genetics, 2019, 10.1038/s41588-018-0303-9
New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders, Elliott, P., Schumann, G., Desrivières, S., Rothenfluh, A., Matthews, P.M., Bell, J.D., Tzoulaki, I., Levy, D., Wilson, J.F., Weir, D.R., Verweij, N., Spector, T.D., Scott, L.J., Samani, N.J., Rudan, I., Raitakari, O.T., Psaty, B.M., Penninx, B.W.J.H., Oldehinkel, A.J., Martin, N.G., Morrison, A.C., Mohlke, K.L., McIntosh, A.M., Lehtimäki, T., Lahti, J., Laakso, M., Kuusisto, J., Kühne, M., Kardia, S.L.R., Kähönen, M., Jarvelin, M.-R., Heath, A.C., Hayward, C., Hartman, C.A., van der Harst, P., Guo, X., Grabe, H.J., Eriksson, J.G., Conen, D., Campbell, H., Boehnke, M., Blakemore, A.I., Veijola, J., Snieder, H., Rotter, J.I., Risch, L., Männikkö, M., Liu, C., Auvinen, J., Arking, D.E., Zhao, W., Yu, B., Yao, J., Wood, A., Whitfield, J.B., Vangipurapu, J., Thériault, S., Tuominen, S., Teumer, A., Stančáková, A., Smith, J.A., Ratliff, S.M., Porteous, D., Polasek, O., Perälä, M.-M., Nolte, I.M., Nelson, C.P., Milaneschi, Y., Mangino, M., Lyytikäinen, L.-P., Lind, P.A., Lemaitre, R.N., Joshi, P.K., Kentistou, K.A., Jackson, A.U., Homuth, G., Faul, J.D., Dimou, N., Clarke, T.-K., Brody, J.A., Brown, M.R., Braund, P.S., Baumeister, S.E., Aeschbacher, S., Bartz, T.M., Luo, Q., Elliott, J., Karaman, I., Yiorkas, A.M., Koskeridis, F., Suzuki, H., Pazoki, R., Butts, A.R., Ntritsos, G., Blakeley, P., Chu, C., Gao, H., Evangelou, E., Nature Human Behaviour, 2019, 10.1038/s41562-019-0653-z
Linking preeclampsia and cardiovascular disease later in life, Forest, J.-C., Lafond, J., Rousseau, F., Laroche, M., Bujold, E., Thériault, S., Charland, M., Giguère, Y., Clinical Chemistry and Laboratory Medicine, 2012, 10.1515/CCLM.2011.764
Multi-ethnic genome-wide association study for atrial fibrillation, Ellinor, P.T., Lunetta, K.L., Zeng, L., Lubitz, S.A., Zeller, T., Yoneda, Z.T., Yao, J., Yang, P.-S., Worrall, B.B., Woo, D., Wong, J.A., Wiggins, K.L., Wells, Q.S., Weiss, S., Weiss, R., Weijs, B., Weeke, P.E., Wang, B., Völker, U., Vlachopoulou, E., Verweij, N., Van Wagoner, D.R., Van Gelder, I.C., Van Der Harst, P., Uitterlinden, A.G., Tveit, A., Tucker, N.R., Trompet, S., Thériault, S., Teumer, A., Teder-Laving, M., Taylor, K.D., Tanriverdi, K., Tanaka, T., Svendsen, J.H., Sun, H., Sun, A., Stricker, B.H., Sotoodehnia, N., Soliman, E.Z., Smith, N.L., Smith, J.D., Smith, J.G., Smith, B.H., Smith, A.V., Slowik, A., Sinner, M.F., Sinisalo, J., Siland, J.E., Shoemaker, M.B., Shim, J., Shalaby, A.A., Shah, S., Shaffer, C., Seppälä, I., Scott, S.A., Schurman, C., Schunkert, H., Schramm, K., Schnabel, R.B., Sandhu, R.K., Saba, S., Rotter, J.I., Rost, N., Rosenberg, M.A., Rosand, J., Roden, D.M., Risch, L., Rienstra, M., Ridker, P.M., Ribasés, M., Refsgaard, L., Rader, D.J., Pullinger, C.R., Pulit, S.L., Psaty, B.M., Porteous, D., Pereira, A., Pera, J., Pedersen, N.L., Paré, G., Pak, H.-N., Padmanabhan, S., Orho-Melander, M., Olesen, M.S., Oellers, H., Noordam, R., Nilsson, P., Nikus, K., Niemeijer, M.N., Newton-Cheh, C., Neumann, B., Nazarian, S., Natale, A., Müller-Nurasyid, M., Morris, A.P., Morley, M.P., Montgomery, J.A., Mohanty, S., Melander, O., McManus, D.D., März, W., Margulies, K.B., Margolin, L., Marcus, G.M., Mansur, A.J., Malik, R., Mahajan, A., Magnusson, P.K., Macfarlane, P.W., Lyytikäinen, L.-P., Lu, Y., Low, S.-K., Loos, R.J.F., London, B., Lokki, M.-L., Lindgren, C.M., Lind, L., Lin, H., Lin, H.J., Lim, H.E., Li, M., Lemaitre, R.N., Leineweber, K., Lehtimäki, T., Laurikka, J., Launer, L.J., Kubo, M., Krieger, J.E., Knight, S., Kleber, M.E., Kirchhof, P., Kietselaer, B.L., Kessler, T., Kavousi, M., Katschnig-Winter, P., Kathiresan, S., Kastrati, A., Kane, J.P., Kamatani, Y., Kähönen, M., Kääb, S., Jukema, J.W., Johnson, R., Jimenez-Conde, J., Ito, K., Ipek, E.G., Ingelsson, E., Huffman, J., Huang, P.L., Huang, J., Horimoto, A.R.V.R., Hofman, A., Hocking, L.J., Hernesniemi, J., Heckbert, S.R., Hayward, C., Harris, T.B., Hamsten, A., Gutmann, R., Gustafsson, S., Gupta, N., Guo, X., Gudnason, V., Grewal, R.P., Geelhoed, B., Franco, O.H., Ford, I., Felix, S.B., Fatkin, D., Eskola, M., Esko, T., Esa, N., Dudley, S.C., Dudink, E.A., Dörr, M., Dichgans, M., Denny, J.C., Delgado, G., Darbar, D., Daniels, B.R., Damrauer, S.M., Cutler, M.J., Crijns, H.J., Cook, J., Conen, D., Cole, J.W., Chung, M.K., Christophersen, I.E., Choi, S.H., Choi, E.-K., Chen, Y.-D.I., Chen, L.Y., Chasman, D.I., Carlquist, J., Cappola, T.P., Campbell, A., Calkins, H., Brody, J.A., Bottinger, E.B., Boerwinkle, E., Bloom, H.L., Bis, J.C., Bihlmeyer, N.A., Benjamin, E.J., Bartz, T.M., Barnard, J., Arking, D.E., Aragam, K.G., Anderson, C.D., Alonso, A., Almgren, P., Albert, C.M., Ahlberg, G., Aeschbacher, S., Weng, L.-C., Chaffin, M.D., Roselli, C., Nature Genetics, 2018, 10.1038/s41588-018-0133-9
Single-cell expression and Mendelian randomization analyses identify blood genes associated with lifespan and chronic diseases, Mathieu, P., Arsenault, B.J., Thériault, S., Bossé, Y., Argaud, D., Li, Z., Boulanger, M.-C., Bon-Baret, V., Chignon, A., Communications Biology, 2020, 10.1038/s42003-020-0937-x
Association of Long-term Exposure to Elevated Lipoprotein(a) Levels With Parental Life Span, Chronic Disease-Free Survival, and Mortality Risk A Mendelian Randomization Analysis, Boekholdt, S.M., Thériault, S., Mathieu, P., Stroes, E.S.G., Pibarot, P., Bossé, Y., Wareham, N.J., Khaw, K.-T., Couture, C., Perrot, N., Kaiser, Y., Pelletier, W., Arsenault, B.J., JAMA Network Open, 2020, 10.1001/jamanetworkopen.2020.0129
Oximetry neither to prescribe long-term oxygen therapy nor to screen for severe hypoxaemia, Maltais, F., Bernatchez, H.J., Sériès, F., Bernard, S., St-Pierre, B., Thériault, S., Lacasse, Y., ERJ Open Research, 2021, 10.1183/23120541.00272-2021
Circulating Galectin-3 Levels Are Not Associated with Nonalcoholic Fatty Liver Disease: A Mendelian Randomization Study, Arsenault, B.J., Thériault, S., Mitchell, P.L., Couture, C., Gobeil, É., Ghodsian, N., Perrot, N., Tremblay, M., Journal of Clinical Endocrinology and Metabolism, 2021, 10.1210/clinem/dgab144
Validation of early risk-prediction models for gestational diabetes based on clinical characteristics, Giguère, Y., Massé, J., Forest, J.-C., Thériault, S., Diabetes Research and Clinical Practice, 2014, 10.1016/j.diabres.2013.12.009
Polygenic risk score predicts prevalence of cardiovascular disease in patients with familial hypercholesterolemia, Baass, A., Paré, G., Dufour, R., Thériault, S., Chong, M., Paquette, M., Journal of Clinical Lipidology, 2017, 10.1016/j.jacl.2017.03.019

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Contribution à l'enseignement aux cycles supérieurs

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Depuis 2009

Pardis Zamani - Maîtrise avec mémoire - En cours
Veronique Boumtje - Doctorat - En cours
Ran Xu - Doctorat - En cours
Ursula Houessou - Doctorat - En cours
Hasanga Dilshan Manik Purage - Doctorat - 2023/09

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