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Université Laval
Faculté de médecine

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Roger C. Levesque

Professeur titulaire

rclevesq@ibis.ulaval.ca
Institut de biologie intégrative et des systèmes
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Contribution à la recherche

Thématiques de recherche de la Faculté de médecine

  • Bioinformatique / données massives (big data)
  • Immunologie-infectiologie
  • Santé cardiovasculaire, respiratoire et métabolisme

Domaines de recherche

  • Génomique
  • Métagénomique environnementale
  • Algorithmes et informatique appliquée à la génomique
  • Microbiologie de l'environnement (y compris la microbiologie de l'air)
  • Microbiologie médicale, n.c.a.
  • Biogéochimie et microbiologie des sols

Projets de recherche en cours

  • Phycotoxins in the Arctic: an emerging climate change risk (PHATE) - Secrétariat des programmes interorganismes à l’intention des établissements - Fonds Nouvelle frontières en recherche - Volet Transformation, University of New Brunswick, co-chercheur - 2025-03-31 au 2029-03-30
  • Sustaining Inuit-Led Assessment and risk management of Harmful Algal Blooms using omins (SILA-HAB)-Lévesque - ArcticNet inc. - Fonds stratégique des sciences, University of New Brunswick, co-chercheur - 2025-04-29 au 2028-03-31
  • Sustaining Inuit-Led Assessment and risk management of Harmful Algal Blooms using omins - ArcticNet inc. - Fonds stratégique des sciences, University of New Brunswick, co-chercheur - 2025-04-29 au 2028-03-31
  • SYNC: Synergistic effects of pesticides and cyanotoxins on phytoplankton communities in an agricultural fluvial lake ecosystem: A case study of the Yamaska River and Lake St-Pierre - Génome Québec - Programme d’intégration de la génomique, Institut national de la recherche scientifique, Université du Québec - INRS, co-chercheur - 2025-07-01 au 2027-06-30
  • MicroPaint: a pipeline for Meta and Genomics Real-Time Monitoring of Antibiotic Resistance Pathogens - Génome Québec - Solutions génomiques pour l’identification, la caractérisation et la surveillance de la résistance aux antimicrobiens et des pathogènes émergents, chercheur principal - 2023-10-01 au 2026-09-30
  • MICPathoScan-Ticks: Microbiome Pathogen Scanning Tick Species and Multiplex Diagnostics of Human Pathogens - Génome Québec - Programme d’intégration de la génomique, chercheur principal - 2023-10-01 au 2025-11-22
  • RosHAB: Rapid on-site detection of harmful algal blooms - Génome Québec, Génome Canada - Programme de partenariats pour les applications de la génomique (PPAG), Institut national de la recherche scientifique, Université du Québec - INRS, co-chercheur - 2022-10-01 au 2025-09-30

Financements des 2 dernières années

  • An evidence-based preclinical framework for the development of antimicrobial therapeutics in cystic fibrosis (PIPE-CF) - Cystic Fibrosis Trust, University of Liverpool, co-chercheur - 2021-10-01 au 2024-03-31
  • A Smart Surveillance Strategy for Carbapenem-resistant Pseudomonas aeruginosa - SAMPAN - Instituts de recherche en santé du Canada - Joint Programming Initiative on Antimicrobial Resistance JPIAMR, Université Érasme de Rotterdam, co-chercheur - 2019-10-01 au 2024-03-01
  • SENTINEL : Stopping Enteric Illnesses Early - Activité 1 - Génome Québec, Génome Canada - Programme de partenariats pour les applications de la génomique (PPAG), University of Guelph, co-chercheur - 2020-07-01 au 2023-06-30
  • SENTINEL : Stopping Enteric Illnesses Early - Activité 3 - Génome Canada, Génome Québec - Programme de partenariats pour les applications de la génomique (PPAG), University of Guelph, co-chercheur - 2020-07-01 au 2023-06-30
  • SENTINEL : Stopping Enteric Illnesses Early - Génome Canada, Ministère de l'agriculture, des pêcheries et de l'alimentation, Génome Québec - Programme de partenariats pour les applications de la génomique (PPAG), University of Guelph, co-chercheur - 2020-07-01 au 2023-06-30

Publications

  • Evaluation of inhibition of the carbenicillin-hydrolyzing β-lactamase PSE-4 by the clinically used mechanism-based inhibitors, Levesque, R.C., Mobashery, S., Sanschagrin, F., Kotra, L.P., Therrien, C., FEBS Letters, 2000, 10.1016/S0014-5793(00)01342-9
  • Characterization of alanine catabolism in Pseudomonas aeruginosa and its importance for proliferation in vivo, Whiteley, M., Levesque, R.C., Barrera, K., Longoria, A., Kukavica-Ibrulj, I., Jorth, P.A., Baynham, P.J., Boulette, M.L., Journal of Bacteriology, 2009, 10.1128/JB.00817-09
  • Identification of in vivo essential genes from Pseudomonas aeruginosa by PCR-based signature-tagged mutagenesis, Levesque, R.C., Sanschagrin, F., Lehoux, D.E., FEMS Microbiology Letters, 2002, 10.1016/S0378-1097(02)00597-9
  • Distinct sources of gene flow produce contrasting population genetic dynamics at different range boundaries of a Choristoneura budworm., , Molecular ecology, 2017, 10.1111/mec.14386
  • Structure-function studies of Ser-289 in the class C β-lactamase from Enterobacter cloacae P99, Huletsky, A., Levesque, R.C., Sanschagrin, F., Clairoux, N., Knox, J.R., Trépanier, S., Antimicrobial Agents and Chemotherapy, 1999, 10.1128/aac.43.3.543
  • Comparative signature-tagged mutagenesis identifies Pseudomonas factors conferring resistance to the pulmonary collectin SP-A, Lau, G.W., McCormack, F.X., Levesque, R.C., Sanschagrin, F., Potvin, E., Chen, Y., Zhang, S., PLoS Pathogens, 2005, 10.1371/journal.ppat.0010031
  • Complete genome sequences of three Pseudomonas aeruginosa isolates with phenotypes of polymyxin B adaptation and inducible resistance, Levesque, R.C., Hancock, R.W., Mendes, C.M.F., Kukavica-Ibrulj, I., Laroche, J., Fernandez, L., Boyle, B., Journal of Bacteriology, 2012, 10.1128/JB.06246-11
  • Primary structure of OXA-3 and phylogeny of oxacillin-hydrolyzing class D β-lactamases, Levesque, R.C., Couture, F., Sanschagrin, F., Antimicrobial Agents and Chemotherapy, 1995, 10.1128/AAC.39.4.887
  • A Syst-OMICS Approach to Ensuring Food Safety and Reducing the Economic Burden of Salmonellosis., , Frontiers in microbiology, 2017, 10.3389/fmicb.2017.00996
  • Novel antimicrobial anionic cecropins from the spruce budworm feature a poly-L-aspartic acid C-terminus., , Proteins, 2021, 10.1002/prot.26142
  • Similar yet different: Phylogenomic analysis to delineate Salmonella and Citrobacter species boundaries, Tamber, S., Goodridge, L., Levesque, R.C., Bekal, S., Verster, A.J., Dussault, F.M., Petronella, N., Pilar, A.V.C., BMC Genomics, 2020, 10.1186/s12864-020-06780-y
  • Direct In Vivo Microbial Transcriptomics During Infection., , Trends in microbiology, 2018, 10.1016/j.tim.2018.07.002
  • Requirement of the Pseudomonas aeruginosa CbrA sensor kinase for full virulence in a murine acute lung infection model, Hancock, R.E.W., Overhage, J., Levesque, R.C., Hilchie, A., Kukavica-Ibrulj, I., Neidig, A., Pena, O.M., Janot, L., Yeung, A.T.Y., Infection and Immunity, 2014, 10.1128/IAI.01527-13
  • Discovery of new MurF inhibitors via pharmacophore modeling and QSAR analysis followed by in-silico screening, Levesque, R.C., Younis, K.S., Zalloum, H., Paradis-Bleau, C., Al-Bakri, A.G., Atallah, N., Taha, M.O., Bioorganic and Medicinal Chemistry, 2008, 10.1016/j.bmc.2007.10.076
  • A needle in a haystack: a multigene TaqMan assay for the detection of Asian gypsy moths in bulk pheromone trap samples, Cusson, M., Hamelin, R.C., Levesque, R.C., Lamarche, J., Zahiri, R., Djoumad, A., Nisole, A., Stewart, D., Biological Invasions, 2019, 10.1007/s10530-019-01943-9
  • Positive signature-tagged mutagenesis in Pseudomonas aeruginosa: Tracking patho-adaptive mutations promoting airways chronic infection, Bragonzi, A., Bertoni, G., Levesque, R.C., Paroni, M., Cigana, C., Milani, A., Bianconi, I., PLoS Pathogens, 2011, 10.1371/journal.ppat.1001270
  • Cloning of SHV-2, OHIO-1, and OXA-6 β-lactamases and cloning and sequencing of SHV-1 β-lactamase, Levesque, R.C., Mercier, J., Antimicrobial Agents and Chemotherapy, 1990, 10.1128/AAC.34.8.1577
  • Structural and functional characterization of tnpI, a recombinase locus in Tn21 and related β-lactamase transposons, Levesque, R.C., Boissinot, M., Vezina, G., Lafond, M., Couture, F., Lachapelle, J., Mercier, J., Journal of Bacteriology, 1990, 10.1128/jb.172.7.3745-3757.1990
  • Fate of 43 Salmonella Strains on Lettuce and Tomato Seedlings., , Journal of food protection, 2019, 10.4315/0362-028x.jfp-18-435
  • Glycoside hydrolase family 32 is present in Bacillus subtilis phages, Levesque, R.C., Maaroufi, H., Virology Journal, 2015, 10.1186/s12985-015-0373-6
  • The Pseudomonas aeruginosa whole genome sequence: A 20th anniversary celebration, Welch, M., Wang, M., Tümmler, B., Schweizer, H.P., Scurlock, M.W., Porter, S.L., Nikel, P.I., Lory, S., Levesque, R.C., Lamont, I.L., Klockgether, J., Häußler, S., Haney, C.H., Hancock, R.E.W., Han, K., Greenberg, E.P., Goldberg, J.B., Francis, V.I., Filloux, A., Done, R.E., Winsor, G.L., Brinkman, F.S.L., Advances in Microbial Physiology, 2021, 10.1016/bs.ampbs.2021.07.001
  • Monoclonal antibodies to TEM-1 plasmid-mediated β-lactamase, Letarte, R., Levesque, R.C., Patel, P.C., Morin, C.J., Antimicrobial Agents and Chemotherapy, 1987, 10.1128/AAC.31.11.1761
  • Nucleotide sequence and phylogeny of SHV-2 β-lactamase, Levesque, R.C., Couture, F., Huletsky, A., Antimicrobial Agents and Chemotherapy, 1990, 10.1128/AAC.34.9.1725
  • Assessing Pseudomonas aeruginosa virulence and the host response using Murine models of acute and chronic lung infection, Bragonzi, A., Levesque, R.C., Cigana, C., Facchini, M., Kukavica-Ibrulj, I., Methods in Molecular Biology, 2014, 10.1007/978-1-4939-0473-0_58
  • Mapping of a plasmid (pLQ3) from Achromobacter and cloning of its cephalosporinase gene in Escherichia coli, Roy, P.H., Levesque, R., Gene, 1982, 10.1016/0378-1119(82)90057-9
  • Design and Evaluation of New Quinazolin-4(3H)-one Derived PqsR Antagonists as Quorum Sensing Quenchers in Pseudomonas aeruginosa., , ACS infectious diseases, 2021, 10.1021/acsinfecdis.1c00175
  • Phenomic and genomic approaches to studying the inhibition of multiresistant Salmonella enterica by microcin J25., , Environmental microbiology, 2020, 10.1111/1462-2920.15045
  • Selection of peptide inhibitors against the Pseudomonas aeruginosa MurD cell wall enzyme, Levesque, R.C., Bugg, T.D.H., Sanschagrin, F., Lloyd, A., Boudreault, L., Beaumont, M., Paradis-Bleau, C., Peptides, 2006, 10.1016/j.peptides.2006.01.017
  • Insights into the molecular basis for the carbenicillinase activity of PSE-4 β-lactamase from crystallographic and kinetic studies, Strynadka, N.C.J., Levesque, R.C., De Castro, L., Passmore, L., Sanschagrin, F., Lim, D., Biochemistry, 2001, 10.1021/bi001653v
  • Broad-host-range mobilizable suicide vectors for promoter trapping in gram-negative bacteria, Antoun, H., Broughton, W.J., Perret, X., Levesque, R.C., Izallalen, M., BioTechniques, 2002, 10.2144/02335st04
  • Preface, Levesque, R.C., Ramos, J.-L., Pseudomonas, 2006, 10.1007/0-387-28881-3
  • The Lon Protease Is Essential for Full Virulence in Pseudomonas aeruginosa, Hancock, R.E.W., Overhage, J., Levesque, R.C., Gellatly, S.L., Kukavica-Ibrulj, I., Taylor, P.K., Fernandez, L., Strehmel, J., Janot, L., Breidenstein, E.B.M., PLoS ONE, 2012, 10.1371/journal.pone.0049123
  • Expansion of LINEs and species-specific DNA repeats drives genome expansion in Asian Gypsy Moths., , Scientific reports, 2019, 10.1038/s41598-019-52840-z
  • Sequencing of the Dutch elm disease fungus genome using the Roche/454 GS-FLX titanium system in a comparison of multiple genomics core facilities, Dewar, K., Levesque, R., Bernier, L., Jacobi, V., Hintz, W., Adams, S., Bintzler, D., Perera, A., Steen, R., Kieleczawa, J., Zianni, M., Peterson, N., Singh, S., Wright, C., Genik, S., Lyons Jr., R., Grove, D., Dias, J., Leveque, G., Forgetta, V., Journal of Biomolecular Techniques, 2013, 10.7171/jbt.12-2401-005
  • Prophage induction reduces Shiga toxin producing Escherichia coli (STEC) and Salmonella enterica on tomatoes and spinach: A model study, Goodridge, L.D., Bisha, B., Coleman, S.M., Chandler, J.C., Bekal, S., Levesque, R.C., Kukavica-Ibrulj, I., Emond-Rheault, J.-G., Freschi, L., Jeukens, J., Colavecchio, A., Cadieux, B., Food Control, 2018, 10.1016/j.foodcont.2018.02.001
  • The Salmonella enterica Plasmidome as a Reservoir of Antibiotic Resistance., , Microorganisms, 2020, 10.3390/microorganisms8071016
  • Comparative genomic analysis of 142 bacteriophages infecting Salmonella enterica subsp. enterica, Ogunremi, D., Goodridge, L., Levesque, R., Moineau, S., Naushad, S., Gao, R., BMC Genomics, 2020, 10.1186/s12864-020-6765-z
  • Discovering essential and infection-related genes, Levesque, R.C., Sanschagrin, F., Lehoux, D.E., Current Opinion in Microbiology, 2001, 10.1016/S1369-5274(00)00244-7
  • Signature-tagged mutagenesis, Levesque, R.C., Kukavica-Ibrulj, I., Methods in Molecular Biology, 2014, 10.1007/978-1-4939-0473-0_41
  • Model-Based Drug Development in Pulmonary Delivery: Pharmacokinetic Analysis of Novel Drug Candidates for Treatment of Pseudomonas aeruginosa Lung Infection., , Journal of pharmaceutical sciences, 2018, 10.1016/j.xphs.2018.09.017
  • Reassessment of the status of Lymantria albescens and Lymantria postalba (Lepidoptera: Erebidae: Lymantriinae) as distinct ‘Asian gypsy moth’ species, using both mitochondrial and nuclear sequence data, Cusson, M., Hamelin, R.C., Levesque, R.C., Martemyanov, V.V., Inoue, M.N., Zahiri, R., Holden, D., Stewart, D., Nisole, A., Djoumad, A., Systematic Entomology, 2020, 10.1111/syen.12410
  • Physical mapping of 32 genetic markers on the Pseudomonas aeruginosa PAO1 chromosome, Levesque, R.C., Hancock, R.E.W., Lam, J.S., Schweizer, H., Siehnel, R., Foster, J., Lightfoot, J., Dewar, K., Morency, M.-J., Ouellet, C., Charlebois, I., Liao, X., Microbiology, 1996, 10.1099/13500872-142-1-79
  • Development of natural and synthetic DNA probes for OXA-2 and TEM-1 β-lactamases, Levesque, R.C., Mercier, J., Boissinot, M., Antimicrobial Agents and Chemotherapy, 1987, 10.1128/AAC.31.5.728
  • A specific peptide inhibitor of the class B metallo-β-lactamase L-1 from Stenotrophomonas maltophilia identified using phage display, Levesque, R.C., Sanschagrin, F., Journal of Antimicrobial Chemotherapy, 2005, 10.1093/jac/dkh550
  • Whole-Genome Sequencing of Lactobacillus Species from Two Commercial Probiotic Products., , Genome announcements, 2017, 10.1128/genomea.01279-17
  • Characterization of tRNA-dependent peptide bond formation by MurM in the synthesis of Streptococcus pneumoniae peptidoglycan, Dowson, C.G., Roper, D.I., Bugg, T.D.H., Tomasz, A., Catherwood, A.C., Levesque, R.C., El Zoeiby, A., De Pascale, G., Blewett, A.M., Gilbey, A.M., Lloyd, A.J., Journal of Biological Chemistry, 2008, 10.1074/jbc.M708105200
  • Draft Genome Sequences of Two Clostridium botulinum Group II Strains Carrying Phage-Like Plasmids., , Microbiology resource announcements, 2022, 10.1128/mra.00091-22
  • Cyclic peptides identified by phage display are competitive inhibitors of the tRNA-dependent amidotransferase of Helicobacter pylori., , Peptides, 2016, 10.1016/j.peptides.2016.03.001
  • Cloning, sequencing and expression in Escherichia coli of the ptsI gene encoding enzyme I of the phosphoenolpyruvate:sugar phosphotransferase transport system from Streptococcus salivarius, Frenette, M., Levesque, R.C., Vadeboncoeur, C., Gagnon, G., Gene, 1992, 10.1016/0378-1119(92)90163-J
  • Molecular structure and interrelationships of multiresistance β-lactamase transposons, Jacoby, G.A., Levesque, R.C., Plasmid, 1988, 10.1016/0147-619X(88)90059-5
  • ASD-GFP vectors for in vivo expression technology in Pseudomonas aeruginosa and other gram-negative bacteria, Levesque, R.C., Hoang, T., Sanschagrin, F., Mahan, M.J., Schweizer, H.P., Handfield, M., BioTechniques, 1998, 10.2144/98242st02
  • Evolutionary perspectives on multiresistance β-lactamase transposons, Levesque, R.C., Vezina, G., Couture, F., Lafond, M., Journal of Bacteriology, 1989, 10.1128/jb.171.12.6423-6429.1989
  • Genome-wide SNPs resolve phylogenetic relationships in the North American spruce budworm (Choristoneura fumiferana) species complex, Sperling, F.A.H., Powell, J.A., Cusson, M., Levesque, R., Boyle, B., Fagua, G., Lumley, L.M., Bird, H.M., Brunet, B.M.T., Dupuis, J.R., Molecular Phylogenetics and Evolution, 2017, 10.1016/j.ympev.2017.04.001
  • For the Safety of Fresh Produce: Regulatory Considerations for Canada on the Use of Whole Genome Sequencing to Subtype Salmonella, Joly, Y., Levesque, R.C., Goodridge, L., Farber, J., Song, L., Dalpé, G., Ngueng Feze, I., Frontiers in Sustainable Food Systems, 2018, 10.3389/fsufs.2018.00021
  • Exacerbation induces a microbiota shift in sputa of COPD patients., , PloS one, 2018, 10.1371/journal.pone.0194355
  • Comparative analysis of mitochondrial genomes of geographic variants of the gypsy moth, Lymantria dispar, reveals a previously undescribed genotypic entity., , Scientific reports, 2017, 10.1038/s41598-017-14530-6
  • The Pseudomonas aeruginosa Population among Cystic Fibrosis Patients in Quebec, Canada: a Disease Hot Spot without Known Epidemic Isolates., , Journal of clinical microbiology, 2019, 10.1128/jcm.02019-18
  • Toxoplasma gondii: Structure and characterization of the 26S ribosomal RNA and peptidyl transferase domain, Levesque, R.C., Bourbeau, D., Morency, M.-J., Gagnon, S., Experimental Parasitology, 1996, 10.1006/expr.1996.0082
  • Major Release of 161 Whole-Genome Sequences from the International Pseudomonas Consortium Database., , Microbiology resource announcements, 2019, 10.1128/mra.00013-19
  • Bacteriophage-Insensitive Mutants of Antimicrobial-Resistant Salmonella Enterica are Altered in their Tetracycline Resistance and Virulence in Caco-2 Intestinal Cells., , International journal of molecular sciences, 2020, 10.3390/ijms21051883
  • Genomic characterisation of environmental Pseudomonas aeruginosa isolated from dental unit waterlines revealed the insertion sequence ISPa11 as a chaotropic element., , FEMS microbiology ecology, 2017, 10.1093/femsec/fix106
  • AnCo3, a new member of the emerging family of phage-like plasmids, Goodridge, L., Levesque, R., Kukavica-Ibrulj, I., Edmond Rheault, J.-G., Freschi, L., Jeukens, J., Colavecchio, A., Genome Announcements, 2017, 10.1128/genomeA.00110-17
  • Complete Genome Sequences of Two Phage-Like Plasmids Carrying the CTX-M-15 Extended-Spectrum β-Lactamase Gene., , Genome announcements, 2017, 10.1128/genomea.00102-17
  • Combined use of Oxford Nanopore and Illumina sequencing yields insights into soybean structural variation biology, François Belzile, Roger C. Levesque, Jérémie Hamel, Davoud Torkamaneh, Jonas A. Sibbesen, Marc-André Lemay, 2021, 10.1101/2021.08.26.457816
  • Mutational spectra are associated with bacterial niche, Julian Parkhill, R. Andres Floto, Tom L. Blundell, Roger C. Lévesque, Gemma G. R. Murray, Marta Matuszewska, Arun Prasad Pandurangan, Gerry Tonkin-Hill, Aaron Weimann, Christopher Ruis, Nature Communications, 2023, 10.1038/s41467-023-42916-w
  • Detection of the pathogenic parasite Toxoplasma gondii by specific amplification of ribosomal sequences using comultiplex polymerase chain reaction, Levesque, R.C., Mercier, J., Gagnon, S., Morency, M.-J., Dubois, D., Guay, J.-M., Journal of Clinical Microbiology, 1993, 10.1128/jcm.31.2.203-207.1993
  • Increase in the in vitro susceptibility of Staphylococcus aureus to antimicrobiol agents in the presence of Candida albicans, Mathieu, L.G., Levesque, R., DeRepentigny, J., Canadian Journal of Microbiology, 1979, 10.1139/m79-066
  • Heterogeneity among virulence and antimicrobial resistance gene profiles of extraintestinal Escherichia coli isolates of animal and human origin, Harel, J., Larivière, S., Masson, L., Brousseau, R., Levesque, R.C., Sanschagrin, F., Bekal, S., Maynard, C., Journal of Clinical Microbiology, 2004, 10.1128/JCM.42.12.5444-5452.2004
  • Sigma factors in Pseudomonas aeruginosa, Levesque, R.C., Sanschagrin, F., Potvin, E., FEMS Microbiology Reviews, 2008, 10.1111/j.1574-6976.2007.00092.x
  • Complete Genome Sequence of a Pseudomonas Species Isolated from Tailings Pond Water in Alberta, Canada., , Microbiology resource announcements, 2021, 10.1128/mra.01174-20
  • An Organ System-Based Synopsis of Pseudomonas aeruginosa Virulence., , Virulence, 2021, 10.1080/21505594.2021.1926408
  • Diabetes: A major co-morbidity of cystic fibrosis, Rabasa-Lhoret, R., Chiasson, J.L., Levesque, R., Lavoie, A., Jeanneret, A., Gauthier, L., Berthiaume, Y., Potvin, S., Costa, M., Diabetes and Metabolism, 2005, 10.1016/S1262-3636(07)70189-1
  • A Pan-Genomic Approach to Understand the Basis of Host Adaptation in Achromobacter., , Genome biology and evolution, 2017, 10.1093/gbe/evx061
  • Roles of amino acids 161 to 179 in the PSE-4 Ω loop in substrate specificity and in resistance to ceftazidime, Levesque, R.C., Palzkill, T., Sanschagrin, F., Therrien, C., Antimicrobial Agents and Chemotherapy, 1998, 10.1128/aac.42.10.2576
  • Molybdate transporter ModABC is important for Pseudomonas aeruginosa chronic lung infection., , BMC research notes, 2016, 10.1186/s13104-016-1840-x
  • Nucleotide sequence of the PSE-4 carbenicillinase gene and correlations with Staphylococcus aureus PC1 β-lactamase crystal structure, Levesque, R.C., Boissinot, M., Journal of Biological Chemistry, 1990
  • Development of gene probes and evolutionary relationships of the PSE-4 bla gene to plasmid-mediated β-lactamases of gram-negative bacteria, Levesque, R.C., Mercier, J., Huot, A., Boissinot, M., Molecular and Cellular Probes, 1989, 10.1016/0890-8508(89)90028-5
  • Letter to the editor: 1H, 13C and 15N backbone resonance assignments for TEM-1, a 28.9 kDa β-lactamase from E. coli [19], Gagné, S.M., Makinen, M.W., Levesque, R.C., Sosa-Peinado, A., Savard, P.-Y., Journal of Biomolecular NMR, 2004, 10.1023/B:JNMR.0000032503.96942.68
  • Draft genome sequences of six Pseudomonas spp. and one Rheinheimera sp. isolated from oil sands process-affected water from Alberta, Canada, Roger C. Levesque, Shawn Lewenza, Irena Kukavica-Ibrulj, Tyson Bookout, Steven M. Shideler, Jeff Gauthier, Kira L. Goff, Microbiology Resource Announcements, 2023, 10.1128/MRA.00589-23
  • Genomic and Phenotypic Analysis of Salmonella enterica Bacteriophages Identifies Two Novel Phage Species, Lawrence Goodridge, Michelle Danyluk, Pascal Delaquis, Roger C. Levesque, Siyun Wang, Brian Boyle, Irena Kukavica-Ibrulj, Margot Amitrano, Elizabeth Tompkins, Zeyan Zhong, Yella Zahirovich-Jovich, Brigitte Cadieux, Anna Colavecchio, Opeyemi U. Lawal, Dr. Sudhakar Bhandare, Microorganisms, 2024, 10.3390/microorganisms12040695
  • Diversity and Host Specificity Revealed by Biological Characterization and Whole Genome Sequencing of Bacteriophages Infecting Salmonella enterica., , Viruses, 2019, 10.3390/v11090854
  • Peptidoglycan lytic activity of the Pseudomonas aeruginosa phage φKZ gp144 lytic transglycosylase, Levesque, R.C., Garnier, A., Auger, M., Laroche, J., Sanschagrin, F., Lemieux, L., Cloutier, I., Paradis-Bleau, C., FEMS Microbiology Letters, 2007, 10.1111/j.1574-6968.2006.00523.x
  • Complete genome sequence of persistent cystic fibrosis isolate Pseudomonas aeruginosa strain RP73, Levesque, R.C., Bragonzi, A., Tümmler, B., Kukavica-Ibrulj, I., Bianconi, I., Boyle, B., Jeukens, J., Genome Announcements, 2013, 10.1128/genomeA.00568-13
  • Application of a High-Throughput Targeted Sequence AmpliSeq Procedure to Assess the Presence and Variants of Virulence Genes in Salmonella, Dele Ogunremi, Lawrence D. Goodridge, Roger C. Levesque, Jérémie Hamel, Hongsheng Huang, Ruimin Gao, Microorganisms, 2022, 10.3390/microorganisms10020369
  • Increasing genomic diversity and evidence of constrained lifestyle evolution due to insertion sequences in Aeromonas salmonicida., , BMC genomics, 2016, 10.1186/s12864-016-2381-3
  • β-lactamases: Clinical and genetic perspectives, Levesque, R., Pechère, J.-C., Journal of Antimicrobial Chemotherapy, 1983, 10.1093/jac/12.6.529
  • Single nucleotide variants in Pseudomonas aeruginosa populations from sputum correlate with baseline lung function and predict disease progression in individuals with cystic fibrosis, B. Jesse Shapiro, Dao Nguyen, Roger Levesque, Brian Boyle, Michael D. Parkins, Nicole Acosta, Inès Levade, Jannik Donner, Morteza M. Saber, 2021, 10.1101/2021.10.04.21264421
  • Pseudomonas aeruginosa PA01 Bacterial Artificial Chromosomes: Strategies for Mapping, Screening, and Sequencing 100 kb Loci of the 5.9 Mb Genome, Levesque, R.C., Birren, B., Sanschagrin, F., Veilleux, F., Cardinal, G., Sabbagh, L., Dewar, K., Microbial and Comparative Genomics, 1998, 10.1089/omi.1.1998.3.105
  • Multiplex polymerase chain reaction for detection and differentiation of the microbial insecticide Bacillus thuringiensis, Levesque, R.C., Lavoie, M.C., Mercier, J., Valero, J.R., Bourque, S.N., Applied and Environmental Microbiology, 1993, 10.1128/aem.59.2.523-527.1993
  • Construction of a DNA probe and detection of Actinobacillus pleuropneumoniae by using polymerase chain reaction, Levesque, R.C., Lemire, E.G., Sirois, M., Journal of Clinical Microbiology, 1991, 10.1128/jcm.29.6.1183-1187.1991
  • Mutational spectra analysis reveals bacterial niche and transmission routes, Julian Parkhill, R. Andres Floto, Tom L. Blundell, Roger C. Lévesque, Gemma G. R. Murray, Marta Matuszewska, Arun Prasad Pandurangan, Gerry Tonkin-Hill, Aaron Weimann, Christopher Ruis, 2022, 10.1101/2022.07.13.499881
  • Reuse of voucher specimens provides insights into the genomic associations and taxonomic value of wing colour and genitalic differences in a pest group (Lepidoptera: Tortricidae: Choristoneura), Sperling, F.A.H., Levesque, R.C., Cusson, M., Lumley, L.M., Brunet, B.M.T., Lebunasin, P.N.A., French, R.L.K., Systematic Entomology, 2020, 10.1111/syen.12416
  • Assessing the potential of genotyping-by-sequencing-derived single nucleotide polymorphisms to identify the geographic origins of intercepted gypsy moth (Lymantria dispar) specimens: A proof-of-concept study, Cusson, M., Hamelin, R.C., Levesque, R.C., Boyle, B., Pouliot, E., Stewart, D., Havill, N., Keena, M., Picq, S., Evolutionary Applications, 2018, 10.1111/eva.12559
  • Peptide inhibitors of the essential cell division protein FtsA, Levesque, R.C., Sanschagrin, F., Paradis-Bleau, C., Protein Engineering, Design and Selection, 2005, 10.1093/protein/gzi008
  • Genomic and Phenotypic Analysis of Salmonella enterica Bac-Teriophages Identifies Two Novel Phage Species, , 1911, 10.20944/preprints202403.0561.v1
  • Secondary structures and features of the 18S, 5.8S and 26S ribosomal RNAs from the Apicomplexan parasite Toxoplasma gondii, Levesque, R.C., Bourbeau, D., Gagnon, S., Gene, 1996, 10.1016/0378-1119(96)00215-6
  • Sequence analysis and evolutionary perspectives of ROB-1 β-lactamase, Levesque, R.C., Juteau, J.-M., Antimicrobial Agents and Chemotherapy, 1990, 10.1128/AAC.34.7.1354
  • Species interactions and distinct microbial communities in high Arctic permafrost affected cryosols are associated with the CH4 and CO2 gas fluxes, Whyte, L.G., Greer, C.W., Lévesque, R., Magnuson, E., Turney, S., Hamel, J., Altshuler, I., Environmental Microbiology, 2019, 10.1111/1462-2920.14715
  • Characteristics and comparative study of five Rhizobium meliloti bacteriophages, Levesque, R.C., Ackermann, H.-W., Werquin, M., Current Microbiology, 1989, 10.1007/BF01575946
  • Draft genome sequences of two lipopeptide-producing strains of Bacillus methylotrophicus, Levesque, R.C., Jabaji, S., Freschi, L., Kukavica-Ibrulj, I., Jeukens, J., Genome Announcements, 2015, 10.1128/genomeA.01176-15
  • Functional genomics PycR, a LysR family transcriptional regulator essential for maintenance of Pseudomonas aeruginosa in the rat lung, Levesque, R.C., MacKay, J., Boyle, B., Whiteley, M., Peterson, A., Sanschagrin, F., Kukavica-Ibrulj, I., Microbiology, 2008, 10.1099/mic.0.2007/011239-0
  • A megaplasmid family responsible for dissemination of multidrug resistance in Pseudomonas, Winstanley, C., Fothergill, J.L., Levesque, R.C., Santanirand, P., Pongchaikul, P., Wright, L.L., Emond-Rhéault, J.-G., Grimes, M., Moore, M.P., Cazares, A., bioRxiv, 2019, 10.1101/630780
  • A colposcopical lesion of the uterine cervix frequently associated with papillomavirus type 16 as detected by in situ and southern blot hybridization: A cytohistological correlation study, Meisels, A., Levesque, R., Fortier, M., Bouchard, C., Morin, C., International Journal of Cancer, 1988, 10.1002/ijc.2910410410
  • Transmission, adaptation and geographical spread of the Pseudomonas aeruginosa Liverpool epidemic strain., , Microbial genomics, 2021, 10.1099/mgen.0.000511
  • 1H, 13C, and 15N backbone resonance assignments for PSE-4, a 29.5 kDa class A beta-lactamase from Pseudomonas aeruginosa., Gagné, S.M., Levesque, R.C., Morin, S., Journal of biomolecular NMR, 2006, 10.1007/s10858-005-5343-7
  • Identification of novel pathogenicity genes by PCR signature-tagged mutagenesis and related technologies., Levesque, R.C., Potvin, E., Kukavica-Ibrulj, I., Sanschagrin, F., Lehoux, D.E., Methods in molecular biology (Clifton, N.J.), 2004, 10.1385/1-59259-763-7:289
  • Two's company, three's a crowd: new insights on spruce budworm species boundaries using genotyping-by-sequencing in an integrative species assessment (Lepidoptera: Tortricidae), Sperling, F.A.H., Cusson, M., LÉVESQUE, R.C., Boyle, B., Lumley, L.M., Muirhead, K., Blackburn, G.S., Brunet, B.M.T., Systematic Entomology, 2017, 10.1111/syen.12211
  • Comparative analysis of the 16S to 23S ribosomal intergenic spacer sequences of Bacillus thuringiensis strains and subspecies and of closely related species, Levesque, R.C., Lavoie, M.C., Valero, J.R., Bourque, S.N., Applied and Environmental Microbiology, 1995, 10.1128/aem.61.4.1623-1626.1995
  • Origin and diversification of endomycorrhizal fungi and coincidence with vascular land plants, Lalonde, M., Lévesque, R.C., Bousquet, J., Simon, L., Nature, 1993, 10.1038/363067a0
  • Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium, Levesque, R.C., Winstanley, C., Tümmler, B., Tucker, N.P., Brinkman, F.S.L., Wright, G.D., Thrane, S.W., Williams, P., Waglechner, N., Turton, J.F., Taylor, V., Stephenson, A., Santos, P.M., Rousseau, S., Rainey, P.B., Pirnay, J.-P., Perron, G.G., Pereira, S.K., Nguyen, D., Naghra, H., Milot, J., McKeown, J., McArthur, A.G., Manos, J., Malouin, F., Loman, N., Lewenza, S., Lamont, I.L., Lam, J.S., Klockgether, J., Kidd, T.J., Kenna, D.T., Jia, B., Jelsbak, L., Heeb, S., Harrison, J.J., Hancock, R.E.W., Grimwood, K., Déziel, É., Dewar, K., Charette, S.J., Cantin, A., Camara, M., Burns, J.L., Bell, S.C., Barbeau, J., Aaron, S.D., Winsor, G.L., Moore, M., Fothergill, J.L., Maaroufi, H., Larose, S., Laroche, J., Dupont, M.-J., Boyle, B., Kukavica-Ibrulj, I., Jeukens, J., Freschi, L., Frontiers in Microbiology, 2015, 10.3389/fmicb.2015.01036
  • Molecular cloning and expression of the imipenem-hydrolyzing β-lactamase gene from pseudomonas maltophilia in escherichia coli, Levesque, R.C., Vezina, G., Dufresne, J., Clinical Infectious Diseases, 1988, 10.1093/clinids/10.4.806
  • Molecular basis of antibiotic resistance and β-lactamase inhibition by mechanism-based inactivators: Perspectives and future directions, Levesque, R.C., Therrien, C., FEMS Microbiology Reviews, 2000, 10.1016/S0168-6445(99)00039-X
  • Strategy for genome sequencing analysis and assembly for comparative genomics of Pseudomonas genomes, Levesque, R.C., Tucker, N.P., Boyle, B., Jeukens, J., Methods in Molecular Biology, 2014, 10.1007/978-1-4939-0473-0_43
  • Genomics of Banchine Ichnoviruses: Insights into their relationship to Bracoviruses and Campoplegine Ichnoviruses, Levesque, R.C., Maaroufi, H., Drezen, J.-M., Volkoff, A.-N., Nisole, A., Béliveau, C., Lapointe, R., Stoltz, D., Cusson, M., Parasitoid Viruses: Symbionts and Pathogens, 2012, 10.1016/B978-0-12-384858-1.00006-0
  • Proteomic, microarray, and signature-tagged mutagenesis analyses of anaerobic Pseudomonas aeruginosa at pH 6.5, likely representing chronic, late-stage cystic fibrosis airway conditions, Hassett, D.J., Hunt, D.F., Kjelleberg, S., Webb, J., Barraud, N., Lieberman, M.A., Rowe, J.J., Limbach, P.A., Lau, G.W., Hwang, S.-H., Schurr, J., Brinkman, F.S.L., Fedynak, A., Levesque, R.C., Potvin, E., Kukavica-Ibrulj, I., Vazquez, G., Sauer, K., Schurr, M.J., Platt, M.D., Journal of Bacteriology, 2008, 10.1128/JB.01683-07
  • Rapid quantitation by PCR of endomycorrhizal fungi colonizing roots, Lalonde, M., Lévesque, R.C., Simon, L., Genome Research, 1992, 10.1101/gr.2.1.76
  • Defined oligonucleotide tag pools and pcr screening in signature-tagged mutagenesis of essential genes from bacteria, Levesque, R.C., Sanschagrin, F., Lehoux, D.E., BioTechniques, 1999, 10.2144/99263st02
  • Molecular characterization of the class II multiresistance transposable element Tn1403 from Pseudomonas aeruginosa, Levesque, R.C., Vezina, G., Antimicrobial Agents and Chemotherapy, 1991, 10.1128/AAC.35.2.313
  • Essential genes in the infection model of Pseudomonas aeruginosa PCR-based signature-tagged mutagenesis, Levesque, R.C., Kukavica-Ibrulj, I., Sanschagrin, F., Methods in Molecular Biology, 2007
  • A megaplasmid family driving dissemination of multidrug resistance in Pseudomonas., , Nature communications, 2020, 10.1038/s41467-020-15081-7
  • Physical and genetic mapping of cloned ribosomal DNA from Toxoplasma gondii: primary and secondary structure of the 5S gene, Levesque, R.C., Tremblay, A., Gagnon, S., Huot, A., Guay, J.-M., Gene, 1992, 10.1016/0378-1119(92)90570-F
  • In vivo-induced genes in Pseudomonas aeruginosa, Levesque, R.C., Woods, D.E., Mahan, M.J., Sanschagrin, F., Lehoux, D.E., Handfield, M., Infection and Immunity, 2000, 10.1128/IAI.68.4.2359-2362.2000
  • Identification of endomycorrhizal fungi colonizing roots by fluorescent single-strand conformation polymorphism-polymerase chain reaction, Lalonde, M., Levesque, R.C., Simon, L., Applied and Environmental Microbiology, 1993, 10.1128/aem.59.12.4211-4215.1993
  • Characterization of the blaCARB-3 gene encoding the carbenicillinase-3 β-lactamase of Pseudomonas aeruginosa, Levesque, R.C., Dufresne, J., Lachapelle, J., Gene, 1991, 10.1016/0378-1119(91)90530-O
  • Salmonella enterica subsp. enterica virulence potential can be linked to higher survival within a dynamic in vitro human gastrointestinal model., , Food microbiology, 2021, 10.1016/j.fm.2021.103877
  • Combinatorial biochemistry and shuffling of TEM, SHV and Streptomyces albus omega loops in PSE-4 class A β-lactamase, Levesque, R.C., Voyer, N., Sabbagh, Y., Thériault, E., Sanschagrin, F., Journal of Antimicrobial Chemotherapy, 2000, 10.1093/jac/45.4.517
  • Biophysical studies of the interactions between the phage φ KZ gp144 lytic transglycosylase and model membranes, Auger, M., Levesque, R.C., Arseneault, M., Pigeon, X., Giroux, A.-M., Paradis-Bleau, C., Cloutier, I., European Biophysics Journal, 2010, 10.1007/s00249-009-0530-1
  • Salmonella enterica Prophage Sequence Profiles Reflect Genome Diversity and Can Be Used for High Discrimination Subtyping., , Frontiers in microbiology, 2018, 10.3389/fmicb.2018.00836
  • Bacteriophage-Induced Lipopolysaccharide Mutations in Escherichia coli Lead to Hypersensitivity to Food Grade Surfactant Sodium Dodecyl Sulfate, , Antibiotics, 2020, 10.3390/antibiotics9090552
  • A plasmid-mediated cepbalosporinase from achromobacter species, Pechere, J.-C., Letarte, R., Roy, P.H., Levesque, R., Journal of Infectious Diseases, 1982, 10.1093/infdis/145.2.753
  • A New Whole Genome Culture-Independent Diagnostic Test (WG-CIDT) for Rapid Detection of Salmonella in Lettuce., , Frontiers in microbiology, 2020, 10.3389/fmicb.2020.00602
  • Draft genomes of 12 host-adapted and environmental isolates of Pseudomonas aeruginosa and their positions in the core genome phylogeny, Tucker, N.P., Levesque, R., Hoskisson, P.A., Crossman, L., Caim, S., Kukavica-Ibrulj, I., Boyle, B., Jeukens, J., Sangal, V., Ford, A., Stewart, L., Pathogens and Disease, 2014, 10.1111/2049-632X.12107
  • Combinatorial enzymatic assay for the screening of a new class of bacterial cell wall inhibitors, Levesque, R.C., Voyer, N., Sanschagrin, F., Dubuc, E., Beaumont, M., Zoeiby, A.E., Bioorganic and Medicinal Chemistry, 2003, 10.1016/S0968-0896(02)00447-9
  • The biology of Mur ligases as an antibacterial target, Paradis-Bleau, C., Levesque, R.C., Kouidmi, I., Molecular Microbiology, 2014, 10.1111/mmi.12758
  • Cloning, over-expression and purification of Pseudomonas aeruginosa murC encoding uridine diphosphate N-acetylmuramate: L-alanine ligase, Levesque, R.C., Darveau, A., Lamoureux, J., Sanschagrin, F., El Zoeiby, A., FEMS Microbiology Letters, 2000, 10.1016/S0378-1097(00)00003-3
  • Draft genome sequence of triclosan-resistant cystic fibrosis isolate Achromobacter xylosoxidans CF304, Levesque, R.C., Nguyen, D., Kukavica-Ibrulj, I., Freschi, L., Jeukens, J., Genome Announcements, 2015, 10.1128/genomeA.00865-15
  • Comparative genomics of a drug-resistant Pseudomonas aeruginosa panel and the challenges of antimicrobial resistance prediction from genomes., , FEMS microbiology letters, 2017, 10.1093/femsle/fnx161
  • Prophage Integrase Typing Is a Useful Indicator of Genomic Diversity in Salmonella enterica., , Frontiers in microbiology, 2017, 10.3389/fmicb.2017.01283
  • PDP-Miner: an AI/ML tool to detect prophage tail proteins with depolymerase domains across thousands of bacterial genomes, Roger C. Levesque, Irena Kukavica-Ibrulj, Jeff Gauthier, 2025, 10.1101/2025.01.20.633936
  • Characterization of Four Novel Bacteriophages Isolated from British Columbia for Control of Non-typhoidal Salmonella in Vitro and on Sprouting Alfalfa Seeds., , Frontiers in microbiology, 2017, 10.3389/fmicb.2017.02193
  • Newly introduced genomic prophage islands are critical determinants of in vivo competitiveness in the liverpool epidemic strain of pseudomonas aeruginosa, Levesque, R.C., Brinkman, F.S.L., Hancock, R.E.W., Parkhill, J., Harris, D., Saunders, D., Seeger, K., Clarke, L., Bignell, A., Lennard, N., Quail, M.A., Winsor, G.L., Thomson, N.R., Sanschagrin, F., Paradis-Bleau, C., Kukavica-Ibrulj, I., Fothergill, J.L., Langille, M.G.I., Winstanley, C., Genome Research, 2009, 10.1101/gr.086082.108
  • The sensor kinase PhoQ mediates virulence in Pseudomonas aeruginosa, Hancock, R.E.W., Levesque, R.C., Cosseau, C., Bains, M., McPhee, J.B., Sanschagrin, F., Gellatly, S.L., Gooderham, W.J., Microbiology, 2009, 10.1099/mic.0.024554-0
  • Transcription of foreign DNA in Escherichia coli, Holt, R.A., Flibotte, S., Smailus, D.E., Levesque, R.C., Freeman, J.D., Warren, R.L., Genome Research, 2008, 10.1101/gr.080358.108
  • Sequencing, assembly and annotation of the whole-insect genome of Lymantria dispar dispar, the European gypsy moth, Gundersen-Rindal, D.E., Levesque, R.C., Cusson, M., Hamelin, R.C., Johnston, J.S., Hebert, F.O., Sparks, M.E., G3: Genes, Genomes, Genetics, 2021, 10.1093/g3journal/jkab150
  • The flagellum of Pseudomonas aeruginosa is required for resistance to clearance by surfactant protein A, Lau, G.W., O'Toole, G.A., Levesque, R.C., McCormack, F.X., Zhang, S., PLoS ONE, 2007, 10.1371/journal.pone.0000564
  • Molecular cloning and DNA homology of plasmid-mediated β-lactamase genes, Jacoby, G.A., Medeiros, A.A., Levesque, R.C., MGG Molecular & General Genetics, 1987, 10.1007/BF00333581
  • The Spruce Budworm Genome: Reconstructing the Evolutionary History of Antifreeze Proteins., , Genome biology and evolution, 2022, 10.1093/gbe/evac087
  • Systematic site-saturation mutagenesis of ROB-1 β-lactamase: Efficiency of T4 polymerase and oligonucleotide synthesis, Levesque, R.C., Cote, S., Juteau, J.-M., BioTechniques, 1991
  • Strategies for isolation of in vivo expressed genes from bacteria, Levesque, R.C., Handfield, M., FEMS Microbiology Reviews, 1999, 10.1016/S0168-6445(98)00033-3
  • Composition of the spruce budworm (Choristoneura fumiferana) midgut microbiota as affected by rearing conditions, Levesque, R.C., Cusson, M., Derome, N., Comeau, A.M., Landry, M., PLoS ONE, 2015, 10.1371/journal.pone.0144077
  • Differential regulation of twitching motility and elastase production by Vfr in Pseudomonas aeruginosa, Mattick, J.S., Levesque, R.C., Sargent, J.L., Whitchurch, C.B., Beatson, S.A., Journal of Bacteriology, 2002, 10.1128/JB.184.13.3605-3613.2002
  • A new approach to study attached biofilms and floating communities from Pseudomonas aeruginosa strains of various origins reveals diverse effects of divalent ions., , FEMS microbiology letters, 2018, 10.1093/femsle/fny155
  • Phage display-derived inhibitor of the essential cell wall biosynthesis enzyme MurF, Levesque, R.C., Bugg, T.D.H., Blewett, A., Clarke, T., Sanschagrin, F., Lloyd, A., Paradis-Bleau, C., BMC Biochemistry, 2008, 10.1186/1471-2091-9-33
  • Liverpool Epidemic Strain Isolates of Pseudomonas aeruginosa Display High Levels of Antimicrobial Resistance during Both Planktonic and Biofilm Growth., , Microbiology spectrum, 2022, 10.1128/spectrum.01024-22
  • In vivo growth of Pseudomonas aeruginosa strains PAO1 and PA14 and the hypervirulent strain LESB58 in a rat model of chronic lung infection, Levesque, R.C., O'Toole, G.A., Sanschagrin, F., Winstanley, C., Paroni, M., Bragonzi, A., Kukavica-Ibrulj, I., Journal of Bacteriology, 2008, 10.1128/JB.01572-07
  • Identification of a ROB-1 β-lactamase in Haemophilus ducreyi, Ronald, A.R., Albritton, W.L., Levesque, R.C., Juteau, J.-M., Slaney, L., Maclean, I.W., Antimicrobial Agents and Chemotherapy, 1992, 10.1128/AAC.36.2.467
  • Combining Whole-Genome Sequencing and Multimodel Phenotyping To Identify Genetic Predictors of Salmonella Virulence., , mSphere, 2020, 10.1128/msphere.00293-20
  • An animal source for the ROB-1 β-lactamase of Haemophilus influenzae type b, Jacoby, G.A., Levesque, R., Medeiros, A.A., Antimicrobial Agents and Chemotherapy, 1986, 10.1128/AAC.29.2.212
  • In vivo functional genomics of Pseudomonas aeruginosa for high-throughput screening of new virulence factors and antibacterial targets, Levesque, R.C., Lau, G.W., Sanschagrin, F., Richard, K.L., Kukavica-Ibrulj, I., Lehoux, D.E., Potvin, E., Environmental Microbiology, 2003, 10.1046/j.1462-2920.2003.00542.x
  • A peptide inhibitor of MurA UDP-N-acetylglucosamine enolpyruvyl transferase: The first committed step in peptidoglycan biosynthesis, Levesque, R.C., Sanschagrin, F., Molina-López, J., Peptides, 2006, 10.1016/j.peptides.2006.08.023
  • Site-saturation mutagenesis and three-dimensional modelling of rob-1 define a substrate binding role of ser 130 in class a β-lactamases, Levesque, R.C., Knox, J.R., Billings, E., Juteau, J.-M., Protein Engineering, Design and Selection, 1992, 10.1093/protein/5.7.693
  • Temperate phages enhance pathogen fitness in chronic lung infection, Winstanley, C., Brockhurst, M.A., Levesque, R.C., Kukavica-Ibrulj, I., James, C.E., Davies, E.V., ISME Journal, 2016, 10.1038/ismej.2016.51
  • Role of Ser-238 and Lys-240 in the hydrolysis of third-generation cephalosporins by SHV-type β-lactamases probed by site-directed mutagenesis and three-dimensional modeling, Levesque, R.C., Knox, J.R., Huletsky, A., Journal of Biological Chemistry, 1993
  • In vitro reconstruction of the biosynthetic pathway of peptidoglycan cytoplasmic precursor in Pseudomonas aeruginosa, Levesque, R.C., Garnier, A., Havugimana, P.C., Sanschagrin, F., El Zoeiby, A., FEMS Microbiology Letters, 2001, 10.1016/S0378-1097(01)00268-3
  • Genomics of antibiotic-resistance prediction in Pseudomonas aeruginosa., , Annals of the New York Academy of Sciences, 2017, 10.1111/nyas.13358
  • Essential genes in the infection model of pseudomonas aeruginosa -PCR-based signature-tagged mutagenesis, Levesque, R.C., Kukavica-Ibrulj, I., Methods in Molecular Biology, 2015, 10.1007/978-1-4939-2398-4_7
  • Genome evolution drives transcriptomic and phenotypic adaptation in Pseudomonas aeruginosa during 20 years of infection, Iain L. Lamont, Roger C. Levesque, Ben Brockway, Marianne Potvin, Lois W. Martin, Jeff Gauthier, Samuel J.T. Wardell, Microbial Genomics, 2021, 10.1099/mgen.0.000681
  • Novel anionic cecropins from the spruce budworm feature a poly-L-aspartic acid C-terminus, Levesque, R.C., Cusson, M., Maaroufi, H., bioRxiv, 2018, 10.1101/307702
  • Parallel solid synthesis of inhibitors of the essential cell division FtsZ enzyme as a new potential class of antibacterials, Levesque, R.C., Voyer, N., Sanschagrin, F., Beaumont, M., Paradis-Bleau, C., Bioorganic and Medicinal Chemistry, 2007, 10.1016/j.bmc.2006.11.015
  • Reservoirs of resistance: polymyxin resistance in veterinary-associated companion animal isolates of Pseudomonas aeruginosa., , The Veterinary record, 2019, 10.1136/vr.105075
  • Complete genome sequence of multidrug-resistant Enterobacter roggenkampii 0-E, Roger C. Levesque, Chantal Brisson, Jimmy Bernier, Vani Mohit, Laure Cockenpot, Irena Kukavica-Ibrulj, Jeff Gauthier, Microbiology Resource Announcements, 2024, 10.1128/mra.01149-23
  • Gene-Gene Interactions Dictate Ciprofloxacin Resistance in Pseudomonas aeruginosa and Facilitate Prediction of Resistance Phenotype from Genome Sequence Data., , Antimicrobial agents and chemotherapy, 2021, 10.1128/aac.02696-20
  • Erratum: Comparative analysis of the 16S to 23S ribosomal intergenic spacer sequences of Bacillus thuringiensis strains and subspecies and of closely related species (Applied and Environmental Microbiology 61:4 (1624- 1626)), Levesque, R.C., Lavoie, M.C., Valero, J.R., Bourque, S.N., Applied and Environmental Microbiology, 1995
  • In vivo functional genomics of pseudomonas: PCR-based signature-tagged mutagenesis, Levesque, R.C., Pseudomonas, 2006, 10.1007/0-387-28881-3_4
  • Convergent herbivory on conifers by Choristoneura moths after boreal forest formation., , Molecular phylogenetics and evolution, 2018, 10.1016/j.ympev.2018.01.013
  • The Pseudomonas aeruginosa Pan-Genome Provides New Insights on Its Population Structure, Horizontal Gene Transfer, and Pathogenicity., , Genome biology and evolution, 2019, 10.1093/gbe/evy259
  • Comparative study of the beta-lactamase activity found in Achromobacter., Pechère, J.C., Letarte, R., Levesque, R., Canadian journal of microbiology, 1983, 10.1139/m83-133
  • Erratum: 1H, 13C, and 15N backbone resonance assignments for PSE-4, a 29.5 kDa class A β-lactamase from Pseudomonas aeruginosa (Journal of Biomolecular NMR 10.1007/s10858-005-5343-7), Gagné, S.M., Levesque, R.C., Morin, S., Journal of Biomolecular NMR, 2006, 10.1007/s10858-006-9069-y
  • Temporal variation in spatial genetic structure during population outbreaks: Distinguishing among different potential drivers of spatial synchrony., , Evolutionary applications, 2019, 10.1111/eva.12852
  • Structure of CARB-4 and AER-1 carbenicillin hydrolyzing β-lactamases, Levesque, R.C., Bejaoui, N., Sanschagrin, F., Antimicrobial Agents and Chemotherapy, 1998, 10.1128/aac.42.8.1966
  • Polymerase chain reaction-based signature-tagged mutagenesis., Levesque, R.C., Lehoux, D.E., Methods in molecular biology (Clifton, N.J.), 2002, 10.1385/1-59259-194-9:127
  • Structure and function of the Mur enzymes: Development of novel inhibitors, Levesque, R.C., Sanschagrin, F., El Zoeiby, A., Molecular Microbiology, 2003, 10.1046/j.1365-2958.2003.03289.x
  • Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm Grown Pseudomonas aeruginosa., , Frontiers in chemistry, 2020, 10.3389/fchem.2020.00204
  • Molecular heterogeneity of the L-1 metallo-β-lactamase family from Stenotrophomonas maltophilia, Levesque, R.C., Dufresne, J., Sanschagrin, F., Antimicrobial Agents and Chemotherapy, 1998, 10.1128/aac.42.5.1245
  • Molecular distribution of ROB-1 β-lactamase in Actinobacillus pleuropneumoniae, Levesque, R.C., Medeiros, A.A., Sirois, M., Juteau, J.-M., Antimicrobial Agents and Chemotherapy, 1991, 10.1128/AAC.35.7.1397
  • Pseudomonas aeruginosa MurE amide ligase: Enzyme kinetics and peptide inhibitor, Levesque, R.C., Bugg, T.D., Roper, D.I., Dowson, C., Blewett, A., Clarke, T., Maaroufi, H., Sanschagrin, F., Lloyd, A., Paradis-Bleau, C., Biochemical Journal, 2009, 10.1042/BJ20081395
  • Decreased outer membrane permeability in imipenem-resistant mutants of Pseudomonas aeruginosa, Nikaido, H., Levesque, R.C., Dufresne, J., Trias, J., Antimicrobial Agents and Chemotherapy, 1989, 10.1128/aac.33.8.1202
  • Structure-function analysis of α-helix H4 using PSE-4 as a model enzyme representative of class A β-lactamases, Levesque, R.C., Voyer, N., Palzkill, T., Sanschagrin, F., Savoie, A., Protein Engineering, 2000, 10.1093/protein/13.4.267
  • Detection of genes essential in specific niches by signature-tagged mutagenesis, Levesque, R.C., Lehoux, D.E., Current Opinion in Biotechnology, 2000, 10.1016/S0958-1669(00)00124-5
  • Characterization of a PSE-4 mutant with different properties in relation to penicillanic acid sulfones: Importance of residues 216 to 218 in class A β-lactamases, Levesque, R.C., Palzkill, T., Voyer, N., Sanschagrin, F., Thériault, E., Sabbagh, Y., Antimicrobial Agents and Chemotherapy, 1998, 10.1128/aac.42.9.2319
  • Structural insights into the putative bacterial acetylcholinesterase ChoE and its substrate inhibition mechanism., , The Journal of biological chemistry, 2020, 10.1074/jbc.ra119.011809
  • Comparative genomics and biological characterization of sequential Pseudomonas aeruginosa isolates from persistent airways infection, Bragonzi, A., Levesque, R.C., Tümmler, B., Kukavica-Ibrulj, I., Molinaro, A., Boyle, B., Facchini, M., Alcalá-Franco, B., Freschi, L., Jeukens, J., Bianconi, I., BMC Genomics, 2015, 10.1186/s12864-015-2276-8
  • Cell culture tracking by multivariate analysis of raw LCMS data, Garnier, A., Levesque, R.C., Bernier, A., Sanschagrin, F., Duchesne, C., Havugimana, P.C., Michaud, F.-T., Applied Biochemistry and Biotechnology, 2012, 10.1007/s12010-012-9661-4
  • PCR screening in signature-tagged mutagenesis of essential genes., Levesque, R.C., Lehoux, D.E., Methods in molecular biology (Clifton, N.J.), 2002, 10.1385/1-59259-177-9:225
  • Model-Informed Drug Development in Pulmonary Delivery: Semimechanistic Pharmacokinetic-Pharmacodynamic Modeling for Evaluation of Treatments against Chronic Pseudomonas aeruginosa Lung Infections., , Molecular pharmaceutics, 2020, 10.1021/acs.molpharmaceut.9b00968
  • A Multi-Species TaqMan PCR Assay for the Identification of Asian Gypsy Moths (Lymantria spp.) and Other Invasive Lymantriines of Biosecurity Concern to North America., , PloS one, 2016, 10.1371/journal.pone.0160878
  • Antimicrobial resistance genes in enterotoxigenic Escherichia coli O149: K91 isolates obtained over a 23-year period from pigs, Harel, J., Larivière, S., Masson, L., Brousseau, R., Levesque, R.C., Sanschagrin, F., Bekal, S., Fairbrother, J.M., Maynard, C., Antimicrobial Agents and Chemotherapy, 2003, 10.1128/AAC.47.10.3214-3221.2003
  • Genomics of the 35-kb pvd locus and analysis of novel pvdIJK genes implicated in pyoverdine biosynthesis in Pseudomonas aeruginosa, Levesque, R.C., Sanschagrin, F., Lehoux, D.E., FEMS Microbiology Letters, 2000, 10.1016/S0378-1097(00)00314-1
  • BAC library construction, screening and clone sequencing of lake whitefish (Coregonus clupeaformis, Salmonidae) towards the elucidation of adaptive species divergence, Bernatchez, L., Lévesque, R.C., St-Cyr, J., Kukavica-Ibrulj, I., Boyle, B., Jeukens, J., Molecular Ecology Resources, 2011, 10.1111/j.1755-0998.2011.02982.x
  • Continent-wide population genomic structure and phylogeography of North America's most destructive conifer defoliator, the spruce budworm (Choristoneura fumiferana)., , Ecology and evolution, 2020, 10.1002/ece3.5950
  • Phylogeny of LCR‐1 and OXA‐5 with class A and class D β‐lactamases, Levesque, R.C., Lachapelle, J., Couture, F., Molecular Microbiology, 1992, 10.1111/j.1365-2958.1992.tb00894.x
  • A multi-host approach to identify a transposon mutant of Pseudomonas aeruginosa LESB58 lacking full virulence., , BMC research notes, 2018, 10.1186/s13104-018-3308-7
  • Identification of novel inhibitors of Pseudomonas aeruginosa MurC enzyme derived from phage-displayed peptide libraries, Levesque, R.C., Brisson, J.-R., Darveau, A., Sanschagrin, F., El Zoeiby, A., Journal of Antimicrobial Chemotherapy, 2003, 10.1093/jac/dkg010
  • Cloning and expression of the imipenem-hydrolyzing β-lactamase operon from Pseudomonas maltophilia in Escherichia coli, Levesque, R.C., Vezina, G., Dufresne, J., Antimicrobial Agents and Chemotherapy, 1988, 10.1128/AAC.32.6.819
  • A standard numbering scheme for the class A β-lactamases [1], Waley, S.G., Tiraby, G., Levesque, R.C., Forsman, M., Joris, B., Ghuysen, J.-M., Frere, J.-M., Coulson, A.F.W., Ambler, R.P., Biochemical Journal, 1991, 10.1042/bj2760269
  • Comparative genomics of isolates of a Pseudomonas aeruginosa epidemic strain associated with chronic lung infections of cystic fibrosis patients, Levesque, R.C., Winstanley, C., Tucker, N.P., Fothergill, J.L., Charette, S.J., Aaron, S.D., Ouellet, M.M., Kukavica-Ibrulj, I., Boyle, B., Jeukens, J., PLoS ONE, 2014, 10.1371/journal.pone.0087611
  • Genomic characterisation of an international Pseudomonas aeruginosa reference panel indicates that the two major groups draw upon distinct mobile gene pools., , FEMS microbiology letters, 2018, 10.1093/femsle/fny120
  • Insights into the Structure of the Spruce Budworm (Choristoneura fumiferana) Genome, as Revealed by Molecular Cytogenetic Analyses and a High-Density Linkage Map., , G3 (Bethesda, Md.), 2018, 10.1534/g3.118.200263
  • Culture-Dependent Bioprospecting of Bacterial Isolates From the Canadian High Arctic Displaying Antibacterial Activity., , Frontiers in microbiology, 2019, 10.3389/fmicb.2019.01836
  • Identification of Pseudomonas aeruginosa FtsZ peptide inhibitors as a tool for development of novel antimicrobials [8], Levesque, R.C., Sanschagrin, F., Paradis-Bleau, C., Journal of Antimicrobial Chemotherapy, 2004
  • Genes required for free phage production are essential for pseudomonas aeruginosa chronic lung infections, Levesque, R.C., Winstanley, C., Tucker, N.P., Laroche, J., Boyle, B., Fothergill, J.L., Kukavica-Ibrulj, I., Jeukens, J., Lemieux, A.-A., Journal of Infectious Diseases, 2016, 10.1093/infdis/jiv415
  • Homology between the genes of octopine catabolism of Rhizobium meliloti A3 and corresponding genes from the Ti plasmid, Dion, P., Kondorosi, A., Levesque, R.C., Beaulieu, C., Bergeron, J., Canadian Journal of Microbiology, 1993, 10.1139/m93-158
  • Molecular cloning, complete sequence of the small subunit ribosomal RNA coding region and phylogeny of Toxoplasma gondii, Gajadhar, A.A., Sogin, M.L., Levesque, R.C., Gagnon, S., Molecular and Biochemical Parasitology, 1993, 10.1016/0166-6851(93)90037-X
  • Inactivation of Salmonella enterica on post-harvest cantaloupe and lettuce by a lytic bacteriophage cocktail., , Current research in food science, 2019, 10.1016/j.crfs.2019.11.004
  • The widespread multidrug-resistant serotype O12 pseudomonas aeruginosa clone emerged through concomitant horizontal transfer of serotype antigen and antibiotic resistance gene clusters, Jelsbaka, L., Lam, J.S., Lévesque, R.C., Pirnay, J.-P., Laroche, J., Boyle, B., Kukavica-Ibrulj, I., Freschi, L., Taylor, V.L., Thrane, S.W., mBio, 2015, 10.1128/mBio.01396-15
  • Functional annotation of the ophiostoma novo-ulmi genome: Insights into the phytopathogenicity of the fungal agent of Dutch elm disease, Bernier, L., Levesque, R.C., Laroche, J., Henrissat, B., Nigg, M., Jacobi, V., Bouvet, G.F., Dufour, J., Comeau, A.M., Genome Biology and Evolution, 2015, 10.1093/gbe/evu281
  • Animal models of chronic lung infection with Pseudomonas aeruginosa: Useful tools for cystic fibrosis studies, Levesque, R.C., Kukavica-Ibrulj, I., Laboratory Animals, 2008, 10.1258/la.2007.06014e
  • Genomic and Phenotypic Analysis of Salmonella enterica Bacteriophages Identifies Two Novel Phage Species, , 1911, 10.20944/preprints202403.0561.v2

Contribution à l'enseignement aux cycles supérieurs

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Depuis 2020/07
  • Anthony Piot - Post-doctorat - En cours

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Direction de recherche dans les domaines suivants :

  • Biologie cellulaire et moléculaire
  • Microbiologie-immunologie

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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Vice-décanat à la recherche et à l'innovation

Pavillon Ferdinand-Vandry
Université Laval
1050, avenue de la Médecine, local 4623
Québec (Québec) G1V 0A6
Canada

Renseignements - Secrétariat
418 656-2690
secretariatvdri@fmed.ulaval.ca

Catherine Mercier
Vice-doyenne à la recherche et à l'innovation