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Pierre Leclerc

Professeur titulaire

pierre.leclerc.4@ulaval.ca

Département d'obstétrique et gynécologie

Centre de recherche en reproduction, développement et santé intergénérationnelle

Centre de recherche du CHU de Québec - Université Laval

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Contribution à la recherche

Thématiques de recherche de la Faculté de médecine

Reproduction, génétique, périnatalité et développement

Domaines de recherche

Différences sexuelles dans les cellules, les tissus et les animaux
Autres médecine fondamentale et sciences de la vie
Signalisation intracellulaire, transduction des signaux, biologie des récepteurs et des membranes

Projets de recherche en cours

Réseau Québécois en Reproduction - Fonds de recherche du Québec - Nature et technologies - Regroupements stratégiques NT, Université de Montréal, co-chercheur - 2024-04-01 au 2030-03-31
Intercellular communication networks and luminal acidification in the post-testicular male reproductive tract - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2022-10-01 au 2027-09-30
Mitochondrial signaling plays an important role in the regulation of sperm motility and fertilizing ability - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2021-10-01 au 2026-09-30
Elucidating the intracellular mechanisms that regulate mammalian sperm fertilizing ability and motility - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2021-04-01 au 2026-03-31
Upgrade of a the CHUQ-UL Axe of reproduction microscopy platfrom - Conseil de recherches en sciences naturelles et génie Canada - Subventions d'outils et d'instruments de recherche (OIR), co-chercheur - 2025-03-31 au 2026-03-31

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Financements des 2 dernières années

Importance de la protéine STAT3 dans la spermiogenèse, l’intégrité et la motilité des spermatozoïdes - Université Laval - Fonds internes - BDR - Contributions, chercheur principal - 2022-07-01 au 2023-06-30
Réseau Québécois en Reproduction (RQR) - Fonds de recherche du Québec - Nature et technologies, Université de Sherbrooke, Université Laval - Fonds internes, Université de Montréal, Université du Québec à Trois-Rivières, Institut national de recherche scientifique (INRS) - Regroupements stratégiques NT, Université de Montréal, co-chercheur - 2017-04-01 au 2023-03-31

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Publications

Semen characteristics of genetically identical quadruplet bulls, Sullivan, R., Leclerc, P., Bailey, J.L., Twagiramungu, H., Kroetsch, T., Bilodeau, J.-F., Masseau, I., Lessard, C., Theriogenology, 2003, 10.1016/S0093-691X(02)01256-6
Recombinant human oviductin regulates protein tyrosine phosphorylation and acrosome reaction, Kan, F.W.K., Leclerc, P., Reid, R.L., Jia, Z., Yang, X., Zhao, Y., Reproduction, 2016, 10.1530/REP-16-0177
Novel technical strategies to optimize cryopreservation of goat semen using cholesterol-loaded cyclodextrin, Bailey, J.L., Leclerc, P., Salmon, V.M., Cryobiology, 2017, 10.1016/j.cryobiol.2016.12.010
The proacrosin binding protein, sp32, is tyrosine phosphorylated during capacitation of pig sperm, Bailey, J.L., Reyes-Moreno, C., Baba, T., Leclerc, P., Dubé, C., Journal of Andrology, 2005, 10.2164/jandrol.04163
Interaction between Ca²⁺, cyclic 3',5' adenosine monophosphate, the superoxide anion, and tyrosine phosphorylation pathways in the regulation of human sperm capacitation, Gagnon, C., De Lamirande, E., Leclerc, P., Journal of Andrology, 1998
The Importance of Calcium in the Appearance of p32, a Boar Sperm Tyrosine Phosphoprotein, during In Vitro Capacitation, Bailey, J.L., Leclerc, P., Tardif, S., Dubé, C., Journal of Andrology, 2003, 10.1002/j.1939-4640.2003.tb02734.x
Mouse sperm adenylyl cyclase: General properties and regulation by the zona pellucida, Kopf, G.S., Leclerc, P., Biology of Reproduction, 1995, 10.1095/biolreprod52.6.1227
Cholesterol-loaded cyclodextrin improves ram sperm cryoresistance in skim milk-extender, Bailey, J.L., Leclerc, P., Demers-Caron, V., Castonguay, F., Salmon, V.M., Animal Reproduction Science, 2017, 10.1016/j.anireprosci.2016.11.011
Characterization of an 80-kilodalton bull sperm protein identified as PH-20, Leclerc, P., Leblanc, V., Dorval, V., Lalancette, C., Biology of Reproduction, 2001, 10.1095/biolreprod65.2.628
Capacitation as a regulatory event that primes spermatozoa for the acrosome reaction and fertilization, Gagnon, C., Leclerc, P., De Lamirande, E., Molecular Human Reproduction, 1997, 10.1093/molehr/3.3.175
Regulation of the human sperm tyrosine kinase c-yes. Activation by cyclic adenosine 3′,5′-monophosphate and inhibition by Ca²⁺, Goupil, S., Leclerc, P., Biology of Reproduction, 2002, 10.1095/biolreprod67.1.301
Implication of the human binder of SPerm Homolog 1 (BSPH1) protein in capacitation, Manjunath, P., Fan, J., Leclerc, P., Lachance, C., Thérien, I., Plante, G., Molecular Human Reproduction, 2014, 10.1093/molehr/gau006
Expression of hck-tr, a truncated form of the src-related tyrosine kinase hck, in bovine spermatozoa and testis, Leclerc, P., Bordeleau, L.-J., Molecular Reproduction and Development, 2008, 10.1002/mrd.20814
Developmental expression of the fragile X-related 1 proteins in mouse testis: Association with microtubule elements, Khandjian, E.W., Leclerc, P., Mazroui, R., Huot, M.-E., Human Molecular Genetics, 2001, 10.1093/hmg/10.24.2803
Calreticulin Affects β-Catenin-associated Pathways, Opas, M., Michalak, M., Blaschuk, O., Symonds, J.M., Dziak, E., Leclerc, P., Szewczenko-Pawlikowski, M., Fadel, M.P., Journal of Biological Chemistry, 2001, 10.1074/jbc.M101676200
Stattic V, a STAT3 inhibitor, affects human spermatozoa through regulation of mitochondrial activity, Leclerc, P., Goupil, S., Lachance, C., Journal of Cellular Physiology, 2013, 10.1002/jcp.24215
Membranous and structural damage that occur during cryopreservation of human sperm may be time-related events, Sullivan, R., Leclerc, P., Légaré, C., Desrosiers, P., Fertility and Sterility, 2006, 10.1016/j.fertnstert.2005.11.046
The protein phosphatase with EF-hand domain 1 is a calmodulin-binding protein that interacts with proteins involved in sperm capacitation, binding to the zona pellucida, and motility, Leclerc, P., Saindon, A.-A., Ruiz, J., Clark, M.-È., Lavoie-Ouellet, C., Molecular Reproduction and Development, 2021, 10.1002/mrd.23467
Role of protein tyrosine phosphorylation in the thapsigargin-induced intracellular Ca²⁺ store depletion during human sperm acrosome reaction, Leclerc, P., Dufour, M., Dorval, V., Molecular Human Reproduction, 2003, 10.1093/molehr/gag017
Direct effect of macrophage migration inhibitory factor on sperm function: possible involvement in endometriosis-associated infertility, Akoum, A., Metz, C.N., Leclerc, P., Carli, C., Fertility and Sterility, 2007, 10.1016/j.fertnstert.2007.04.002
Identification of the bull sperm p80 protein as a PH-20 ortholog and its modification during the epididymal transit, Leclerc, P., Sullivan, R., Lalancette, C., Morin, G., Molecular Reproduction and Development, 2005, 10.1002/mrd.20308
Epididymosomes transfer epididymal sperm binding protein 1 (ELSPBP1) to dead spermatozoa during epididymal transit in bovine, Sullivan, R., Blondin, P., Leclerc, P., Allard, N., Bordeleau, L.-J., Frenette, G., D'Amours, O., Biology of Reproduction, 2012, 10.1095/biolreprod.112.100990 1-11
Cyclic adenosine 3',5'monophosphate-dependent regulation of protein tyrosine phosphorylation in relation to human sperm capacitation and motility, Gagnon, C., De Lamirande, E., Leclerc, P., Biology of Reproduction, 1996, 10.1095/biolreprod55.3.684
Capacitation of mouse spermatozoa. II. Protein tyrosine phosphorylation and capacitation are regulated by a cAMP-dependent pathway, Kopf, G.S., Olds-Clarke, P., Pan, D., Connors, S.A., Leclerc, P., Bailey, J.L., Moore, G.D., Visconti, P.E., Development, 1995
Cyclic nucleotide phosphodiesterases in human spermatozoa and seminal fluid: Presence of an active PDE10A in human spermatozoa, Richard, F.J., Leclerc, P., Blondin, P., Goupil, S., Guillemette, C., Maréchal, L., Biochimica et Biophysica Acta - General Subjects, 2017, 10.1016/j.bbagen.2016.11.006
Use of phosphoproteomics to study tyrosine kinase activity in capacitating boar sperm: Kinase activity and capacitation, Leclerc, P., Lefièvre, L., Reyes-Moreno, C., Beaulieu, M., Dubé, C., Tardif, S., Bailey, J.L., Theriogenology, 2005, 10.1016/j.theriogenology.2004.09.034
Cholesterol-loaded cyclodextrin increases the cholesterol content of goat sperm to improve cold and osmotic resistance and maintain sperm function after cryopreservation, Bailey, J.L., Leclerc, P., Salmon, V.M., Biology of Reproduction, 2016, 10.1095/biolreprod.115.128553
Increased activity of the human sperm tyrosine kinase SRC by the cAMP-dependent pathway in the presence of calcium, Leclerc, P., Goupil, S., Lawson, C., Biology of Reproduction, 2008, 10.1095/biolreprod.108.070367
Papaverine-sensitive phosphodiesterase activity is measured in bovine spermatozoa, Richard, F.J., Vigneault, C., Blondin, P., Sullivan, R., Leclerc, P., Aragon, J.P., Poulin, M.-P., Laroche, A., Guillemette, C., Hébert, A., Bergeron, A., Andrology, 2017, 10.1111/andr.12290
Leukemia inhibitory factor regulates differentiation of trophoblastlike BeWo cells through the activation of JAK/STAT and MAPK3/1 MAP kinase-signaling pathways, Reyes-Moreno, C., Lafond, J., Leclerc, P., Asselin, É., Bourassa, V., Leduc, K., Biology of Reproduction, 2012, 10.1095/biolreprod.111.094334
Identification of the proteins present in the bull sperm cytosolic fraction enriched in tyrosine kinase activity: A proteomic approach, Leclerc, P., Faure, R.L., Lalancette, C., Proteomics, 2006, 10.1002/pmic.200500578
Inhibitors of phosphoinositide 3-kinase, LY294002 and wortmannin, affect sperm capacitation and associated phosphorylation of proteins differently: Ca²⁺-dependent divergences, Gagnon, C., Leclerc, P., De Lamirande, E., Nauc, V., Journal of Andrology, 2004, 10.1002/j.1939-4640.2004.tb02828.x
Cytogenetic study of parthenogenetically activated bovine oocytes matured in vivo and in vitro, Jacques, P., Lambert, R.D., Leclerc, P., Greve, T., Sirard, M.‐A., Xu, K.P., King, W.A., Gamete Research, 1988, 10.1002/mrd.1120200303
Localization of the chaperone proteins GRP78 and HSP60 on the luminal surface of bovine oviduct epithelial cells and their association with spermatozoa, Leclerc, P., Sirard, M.-A., Bailey, J.L., Massicotte, L., Lachance, C., Reyes-Moreno, C., Boilard, M., Biology of Reproduction, 2004, 10.1095/biolreprod.103.026849
SPAM1 isoforms from two tissue origins are differentially localized within ejaculated bull sperm membranes and have different roles during fertilization., Leclerc, P., Robert, C., Laflamme, I., Sullivan, R., Morin, G., Biology of reproduction, 2010, 10.1095/biolreprod.109.079582
Dr Claude Gagnon., Robaire, B., Lefievre, L., Leclerc, P., de Lamirande, E., O'Flaherty, C., Journal of andrology, 2012, 10.2164/jandrol.112.017426
Erratum: Decreased binding of calmodulin to bull sperm proteins during heparin-induced capacitation (Biol. Reprod. 1990; 42: 483-489), Lambert, R.D., Chefouleas, J.G., Sirard, M.-A., Leclerc, P., Biology of Reproduction, 1990
Evidence for the role of heterotrimeric guanine nucleotide-binding regulatory proteins in the regulation of the mouse sperm adenylyl cyclase by the egg's zona pellucida, Kopf, G.S., Leclerc, P., Journal of Andrology, 1999
Implication of calmodulin-dependent phosphodiesterase type 1 during bovine sperm capacitation, Bailey, J.L., Cormier, N., Leclerc, P., Fournier, V., Journal of Andrology, 2003
p95, the major phosphotyrosine-containing protein in mouse spermatozoa, is a hexokinase with unique properties, Kopf, G.S., Leclerc, P., Visconti, P., Kalab, P., Journal of Biological Chemistry, 1994
Bull testicular haploid germ cells express a messenger encoding for a truncated form of the protein tyrosine kinase HCK, Leclerc, P., Faure, R.L., Bordeleau, L.-J., Lalancette, C., Molecular Reproduction and Development, 2006, 10.1002/mrd.20422
Regulation of protein-tyrosine phosphorylation and human sperm capacitation by reactive oxygen derivatives, Gagnon, C., De Lamirande, E., Leclerc, P., Free Radical Biology and Medicine, 1997, 10.1016/S0891-5849(96)00379-6
Cryopreservation affects bovine sperm intracellular parameters associated with capacitation and acrosome exocytosis, Leclerc, P., Bailey, J.L., Pons-Rejraji, H., Reproduction, Fertility and Development, 2009, 10.1071/RD07170
The immobilization of human spermatozoa by STAT3 inhibitory compound V results from an excessive intracellular amount of reactive oxygen species, Leclerc, P., Tremblay, R.R., Lachance, C., Goupil, S., Andrology, 2016, 10.1111/andr.12123
Identification and localization of the cyclic nucleotide phosphodiesterase 10A in bovine testis and mature spermatozoa, Leclerc, P., Richard, F.J., Tremblay, M.-È., Hajj, H.E., Maréchal, L., Goupil, S., PLoS ONE, 2016, 10.1371/journal.pone.0161035
SPAM1 and PH-20 are two gene products expressed in bovine testis and present in sperm, Leclerc, P., Saindon, A.-A., Reproduction, 2018, 10.1530/REP-18-0185
Regulation of the phosphotyrosine content of human sperm proteins by intracellular Ca²⁺: Role of Ca²⁺-adenosine triphosphatases, Leclerc, P., Dufour, M., Dorval, V., Biology of Reproduction, 2002, 10.1095/biolreprod.102.004127
Distribution and localization of calmodulin-binding proteins in bull spermatozoa, Goupil, S., Leclerc, P., Biology of Reproduction, 2000, 10.1095/biolreprod62.6.1875
Cryopreservation alters the levels of the bull sperm surface protein P25b, Sullivan, R., Baileys, J.A.N.I.C.E.L., Leclerc, P., Parent, S., Lessard, C., Journal of Andrology, 2000, 10.1002/j.1939-4640.2000.tb02138.x
Effect of heparin on the expression of calmodulin-binding proteins in bull spermatozoa, Chafouleas, J.G., Sirard, M.A., Lambert, R.D., Langlais, J., Leclerc, P., Journal of Reproduction and Fertility, 1989, 10.1530/jrf.0.0850615
Proteomic comparison of detergent-extracted sperm proteins from bulls with different fertility indexes, Sullivan, R., Leclerc, P., Fortier, M., Frenette, G., D'Amours, O., Reproduction, 2010, 10.1530/REP-09-0375
Expression of Hsp60 and Grp78 in the human endometrium and oviduct, and their effect on sperm functions, Leclerc, P., Bailey, J.L., Lachance, C., Human Reproduction, 2007, 10.1093/humrep/dem242
Infertility in a beef bull due to a failure in the capacitation process, Palmer, C., Leclerc, P., Sullivan, R., D'Amours, O., Siqueira, L.G., Lessard, C., Theriogenology, 2011, 10.1016/j.theriogenology.2011.04.020
Problems with the estimation of urine protein by automated assays, Douville, P., Leclerc, P., Girouard, J., Dube, J., Clinical Biochemistry, 2005, 10.1016/j.clinbiochem.2004.12.010
In vitro fertilization of bovine oocytes matured in vivo and collected at laparoscopy, Bedoya, M., Ménard, D.P., Leclerc, P., Rioux, J.E., Béland, R., Bernard, C., Sirard, M.a., Lambert, R.D., Theriogenology, 1986, 10.1016/0093-691X(86)90188-3
Investigation of MYST4 histone acetyltransferase and its involvement in mammalian gametogenesis, Sirard, M.-A., Leclerc, P., Vigneault, C., Morin, G., McGraw, S., BMC Developmental Biology, 2007, 10.1186/1471-213X-7-123
Study on the role of calmodulin in sperm function through the enrichment and identification of calmodulin-binding proteins in bovine ejaculated spermatozoa, Saindon, A.-A., Ruiz, J., Clark, M.-È., Lavoie-Ouellet, C., Rioux, J.-F., Goupil, S., Leclerc, P., Journal of Cellular Physiology, 2020, 10.1002/jcp.29421
Modulation of bovine sperm signalling pathways: Correlation between intracellular parameters and sperm capacitation and acrosome exocytosis, Leclerc, P., Bailey, J.L., Pons-Rejraji, H., Reproduction, Fertility and Development, 2009, 10.1071/RD07169
Decrease in calmodulin concentrations during heparin-induced capacitation in bovine spermatozoa, Lambert, R.D., Chafouleas, J.G., Sirard, M.A., Leclerc, P., Journal of Reproduction and Fertility, 1992, 10.1530/jrf.0.0940023
Decreased binding of calmodulin to bull sperm proteins during heparin-induced capacitation, Lambert, R.D., Chafouleas, J.G., Sirard, M.-A., Leclerc, P., Biology of Reproduction, 1990, 10.1095/biolreprod42.3.483
Regulated expression of cadherin-6 and cadherin-11 in the glandular epithelial and stromal cells of the human endometrium, Maccalman, C.D., Blaschuk, O.W., Leclerc, P., Stephenson, M.D., Chen, G.T.C., Getsios, S., Developmental Dynamics, 1998, 10.1002/(SICI)1097-0177(199803)211:3<238::AID-AJA5>3.0.CO;2-I
Localization of Hsp60 and Grp78 in the human testis, epididymis and mature spermatozoa, Leclerc, P., Bailey, J.L., Sullivan, R., Thimon, V., Fortier, M., Lachance, C., International Journal of Andrology, 2010, 10.1111/j.1365-2605.2008.00948.x
Induction of human sperm capacitation and protein tyrosine phosphorylation by endometrial cells and interleukin-6, Leclerc, P., Akoum, A., Laflamme, J., Molecular Human Reproduction, 2005, 10.1093/molehr/gah142
Mediators of the JAK/STAT signaling pathway in human spermatozoa, Leclerc, P., Lachance, C., Biology of Reproduction, 2011, 10.1095/biolreprod.111.092379
Binder of sperm 1 and epididymal sperm binding protein 1 are associated with different bull sperm subpopulations, Sullivan, R., Leclerc, P., Blondin, P., Frenette, G., Bordeleau, L.-J., D'Amours, O., Reproduction, 2012, 10.1530/REP-11-0392
Phosphorylation of triton X-100 soluble and insoluble protein substrates in a demembranated/reactivated human sperm model, Gagnon, C., Leclerc, P., Molecular Reproduction and Development, 1996, 10.1002/(SICI)1098-2795(199606)44:2<200::AID-MRD9>3.0.CO;2-R
Developmental expression of Src-related tyrosine kinases in the mouse testis, Leclerc, P., Bordeleau, L.-J., Trasler, J.M., La Salle, S., Goupil, S., Journal of Andrology, 2011, 10.2164/jandrol.110.010462
Estrogen sulfotransferase is highly expressed along the bovine epididymis and is secreted into the intraluminal environment, Sullivan, R., D'Amours, O., Leclerc, P., Frenette, G., Journal of Andrology, 2009, 10.2164/jandrol.108.006668
Identification and localisation of SERCA 2 isoforms in mammalian sperm, Leclerc, P., Goupil, S., Dorval, V., Lawson, C., Molecular Human Reproduction, 2007, 10.1093/molehr/gam012

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Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2020/07

Tania Laperrière - Maîtrise avec mémoire - En cours
Samira Kanouni - Maîtrise avec mémoire - En cours
Jolianne Bernier - Maîtrise avec mémoire - En cours
Rohit Kumar Deshmukh - Doctorat - En cours
Edith Gosselin - Maîtrise avec mémoire - En cours
Camille Lavoie-Ouellet - Maîtrise avec mémoire - 2021/05
Ariane Lapointe-Belleau - Maîtrise avec mémoire - 2024/05
Sandrine Delisle - Maîtrise avec mémoire - 2024/09

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Biologie cellulaire et moléculaire
Médecine moléculaire

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