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Philippe Tessier

Professeur titulaire

Philippe Tessier
Centre de recherche du CHU de Québec - Université Laval
Centre de recherche en arthrite (ARThrite)
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :


Domaines et intérêts de recherche du (de la) professeur(e) :

Appareil locomoteur et arthrite
  • Peau

Projets de recherche

  • Developing synthetic S100A9-based molecules for differentiation therapy of human acute myeloid leukemia - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2022-04-01 au 2027-03-31
  • Biology of S100A8 and S100A9 proteins in Human Acute Myeloid Leukemia - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2019-10-01 au 2024-09-30
  • Surveillance des réponses immunitaires au vaccin contre la COVID-19 chez les personnes vivant avec le VIH-1 - Instituts de recherche en santé du Canada - Subvention de fonctionnement:Nouveaux besoins prioritaires en recherche sur la COVID-19, co-chercheur - 2021-12-01 au 2022-11-30
  • Profil moléculaire sanguin de patientes souffrant de lupus - CHU de Québec – Université Laval – CHUL - Développement de la recherche (RFI), co-chercheur - 2019-04-01 au 2021-03-31


  • Quinoline-3-carboxamides such as tasquinimod are not specific inhibitors of S100A9, Martin Pelletier, Jean-Christophe Simard, Denis Girard, Philippe A. Tessier, Blood Advances, 2018, 10.1182/bloodadvances.2018016667
  • S100A9 induces differentiation of acute myeloid leukemia cells through TLR4, Malika Laouedj, Mélanie R. Tardif, Laurine Gil, Marie-Astrid Raquil, Asmaa Lachhab, Martin Pelletier, Philippe A. Tessier, Frédéric Barabé, Blood, 2017, 10.1182/blood-2016-09-738005
  • An Inflammation Loop Orchestrated by S100A9 and Calprotectin Is Critical for Development of Arthritis, Anceriz, N., Cesaro, A., Pagé, N., Plante, A., Tardif, M.R., Tessier, P.A., PLoS ONE, 2012, 10.1371/journal.pone.0045478
  • Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria, Alenghat, T., Artis, D., Bushman, F.D., Chang, K.-M., Collman, R.G., Farber, D.L., Fouser, L.A., Friedman, J.R., Fung, T.C., Grunberg, S., Hutnick, N.A., Kiyono, H., Kubota, M., Kunisawa, J., Monticelli, L.A., Sathaliyawala, T., Shaked, A., Shibata, N., Sinha, R., Sonnenberg, G.F., Tardif, M.R., Tessier, P.A., Weiner, D.B., Zahm, A.M., Science, 2012, 10.1126/science.1222551
  • Damage-associated molecular pattern S100A9 increases bactericidal activity of human neutrophils by enhancing phagocytosis, Girard, D., Simard, J.-C., Simon, M.-M., Tessier, P.A., Journal of Immunology, 2011, 10.4049/jimmunol.1002956
  • Induction of neutrophil degranulation by S100A9 via a MAPK-dependent mechanism, Girard, D., Simard, J.-C., Tessier, P.A., Journal of Leukocyte Biology, 2010, 10.1189/jlb.1009676
  • Surface RANKL of Toll-like receptor 4-stimulated human neutrophils activates osteoclastic bone resorption, Chakravarti, A., Poubelle, P.E., Raquil, M.-A., Tessier, P., Blood, 2009, 10.1182/blood-2008-09-178301
  • Blockade of antimicrobial proteins S100A8 and S100A9 inhibits phagocyte migration to the alveoli in streptococcal pneumonia, Anceriz, N., Raquil, M.-A., Rouleau, P., Tessier, P.A., Journal of Immunology, 2008
  • Different expression ratio of S100A8/A9 and S100A12 in acute and chronic lung diseases, Alexis, N.E., Duncan Hite, R., Lorenz, E., Meredith, W., Muhlebach, M.S., Peden, D.B., Seeds, M.C., Tessier, P.A., Respiratory Medicine, 2008, 10.1016/j.rmed.2007.11.011
  • Localization of S100A8 and S100A9 expressing neutrophils to spinal cord during peripheral tissue inflammation, Iadarola, M.J., Keller, J.M., Mezey, E., Mitchell, K., Muhly, W.T., Swaim, W.D., Szalayova, I., Tessier, P.A., Yang, H.-Y.T., Pain, 2008, 10.1016/j.pain.2007.10.024
  • Myeloid-related proteins rapidly modulate macrophage nitric oxide production during innate immune response, Olivier, M., Plante, I., Pouliot, P., Raquil, M.-A., Tessier, P.A., Journal of Immunology, 2008
  • Extracellular nucleotides mediate LPS-induced neutrophil migration in vitro and in vivo, Kukulski, F., Lefebvre, J., Sévigny, J., Tessier, P.A., Warny, M., Yebdri, F.B., Journal of Leukocyte Biology, 2007, 10.1189/jlb.1206758
  • Immunogenicity of papaya mosaic virus-like particles fused to a hepatitis C virus epitope: Evidence for the critical function of multimerization, Acosta-Ramirez, E., Bedard, M.-C., Bolduc, M., Denis, J., Lacasse, P., Lamarre, A., Lapointe, R., Leclerc, D., Lecours, K., Lopez Macias, C., Majeau, N., Pare, C., Savard, C., Shoukry, N., Simard, S., Tessier, P., Willems, B., Virology, 2007, 10.1016/j.virol.2007.01.011
  • S100A9 mediates neutrophil adhesion to fibronectin through activation of β2 integrins, Anceriz, N., Tessier, P.A., Vandal, K., Biochemical and Biophysical Research Communications, 2007, 10.1016/j.bbrc.2006.12.203
  • Evidence for chronic, peripheral activation of neutrophils in polyarticular juvenile rheumatoid arthritis, Cadwell, C., Centola, M., Chen, Y., Dozmorov, I., Frank, M.B., Jarvis, J.N., Jiang, K., Kindzelski, A., McGhee, J.L., Petty, H.R., Szodoray, P., Tang, Y., Tessier, P.A., Turner, M., Arthritis Research and Therapy, 2006, 10.1186/ar2048
  • Proteomic identification of in vivo substrates for matrix metalloproteinases 2 and 9 reveals a mechanism for resolution of inflammation, Cook, R.G., Corry, D.B., Engler, D.A., Greenlee, K.J., Kheradmand, F., Matsunami, R.K., Tessier, P., Werb, Z., Journal of Immunology, 2006
  • S100A8 and S100A9 activate MAP kinase and NF-κB signaling pathways and trigger translocation of RAGE in human prostate cancer cells, De Servi, B., Hermani, A., Mayer, D., Medunjanin, S., Tessier, P.A., Experimental Cell Research, 2006, 10.1016/j.yexcr.2005.10.013
  • S100A8 chemotactic protein is abundantly increased, but only a minor contributor to LPS-induced, steroid resistant neutrophilic lung inflammation in vivo, Anderson, G.P., Bozinovski, S., Cross, M., Geczy, C.L., Hamilton, J.A., Hsuu, K., Hume, D.A., Jones, J.E., Reynolds, E.C., Tessier, P.A., Vlahos, R., Journal of Proteome Research, 2005, 10.1021/pr049829t
  • Hemozoin-Inducible Proinflammatory Events In Vivo: Potential Role in Malaria Infection, Jaramillo, M., Olivier, M., Ouellet, N., Plante, I., Tessier, P.A., Vandal, K., Journal of Immunology, 2004
  • Monosodium urate monohydrate crystals induce the release of the proinflammatory protein S100A8/A9 from neutrophils, De Médicis, R., Gilbert, C., Lussier, A., Ryckman, C., Tessier, P.A., Vandal, K., Journal of Leukocyte Biology, 2004, 10.1189/jlb.0603294
  • Toll-like receptor 2 represses nonpilus adhesin-induced signaling in acute infections with the Pseudomonas aeruginosa pilA mutant, Chemotti, D.C., Lorenz, E., Tessier, P.A., Vandal, K., Infection and Immunity, 2004, 10.1128/IAI.72.8.4561-4569.2004
  • Blockade of S100A8 and S100A9 suppresses neutrophil migration in response to lipopolysaccharide, Boivin, A., Rouleau, P., Ryckman, C., Talbot, M., Tessier, P.A., Vandal, K., Journal of Immunology, 2003
  • Proinflammatory activities of S100: Proteins S100A8, S100A9, and S100A8/A9 induce neutrophil chemotaxis and adhesion, Rouleau, P., Ryckman, C., Talbot, M., Tessier, P.A., Vandal, K., Journal of Immunology, 2003
  • Role of S100A8 and S100A9 in neutrophil recruitment in response to monosodium urate monohydrate crystals in the air-pouch model of acute gouty arthritis, De Médicis, R., Lussier, A., McColl, S.R., Poubelle, P.E., Ryckman, C., Tessier, P.A., Vandal, K., Arthritis and Rheumatism, 2003, 10.1002/art.11079
  • The calcium-binding protein S100A12 induces neutrophil adhesion, migration, and release from bone marrow in mouse at concentrations similar to those found in human inflammatory arthritis, Boivin, A., Poubelle, P.E., Rouleau, P., Ryckman, C., Talbot, M., Tessier, P.A., Vandal, K., Clinical Immunology, 2003, 10.1016/S1521-6616(02)00043-8
  • HIV-1 transcription and virus production- are both accentuated by the proinflammatory myeloid-related proteins in human CD4+ T lymphocytes, Cantin, R., Robichaud, G.A., Roy, J., Ryckman, C., Tessier, P.A., Tremblay, M.J., Journal of Immunology, 2002
  • The S100 family heterodimer, MRP-8/14, binds with high affinity to heparin and heparan sulfate glycosaminoglycans on endothelial cells, Hogg, N., Poulsom, R., Robinson, M.J., Tessier, P., Journal of Biological Chemistry, 2002, 10.1074/jbc.M102950200
  • Activation of human neutrophils in vitro and dieldrin-induced neutrophilic inflammation in vivo, Gauthier, M., Girard, D., Pelletier, M., Roberge, C.J., Tessier, P.A., Vandal, K., Journal of Leukocyte Biology, 2001
  • The use of lymphocyte function-associated antigen (LFA)-1-deficient mice to determine the role of LFA-1, Mac-1, and α4 integrin in the inflammatory response of neutrophils, Gavins, F.N.E., Henderson, R.B., Hogg, N., Lim, L.H.K., Mathies, M., Perretti, M., Tessier, P.A., Journal of Experimental Medicine, 2001, 10.1084/jem.194.2.219
  • Induction of acute inflammation in vivo by staphylococcal superantigens I: Leukocyte recruitment occurs independently of T lymphocytes and major histocompatibility complex class II molecules, Diener, K., Fraser, J., Königen, F., McColl, S.R., Tessier, P., Laboratory Investigation, 1998
  • Induction of acute inflammation in vivo by staphylococcal superantigens. II. Critical role for chemokines, ICAM-1, and TNF-α, Clark-Lewis, I., Diener, K.R., Gladue, R.P., McColl, S.R., Naccache, P.H., Neote, K.S., Tessier, P.A., Journal of Immunology, 1998
  • Chemokine Networks in Vivo: Involvement of C-X-C and C-C Chemokines in Neutrophil Extravasation in Vivo in Response to TNF-α, Clark-Lewis, I., Gladue, R.P., McColl, S.R., Naccache, P.H., Neote, K.S., Tessier, P.A., Journal of Immunology, 1997
  • Inhibition of lymphocyte adhesion to cytokine-activated synovial fibroblasts by glucocorticoids involves the attenuation of vascular cell adhesion molecule 1 and intercellular adhesion molecule 1 gene expression, Cattaruzzi, P., McColl, S.R., Tessier, P.A., Arthritis and Rheumatism, 1996
  • Up-regulation by tumor necrosis factor α of intercellular adhesion molecule 1 expression and function in synovial fibroblasts and its inhibition by glucocorticoids, Audette, M., Cattaruzzi, P., McColl, S.R., Tessier, P., Arthritis and Rheumatism, 1993, 10.1002/art.1780361107
  • Regulation by retinoic acid of ICAM-1 expression on human tumor cell lines, Audette, M., Bouillon, M., Boulianne, R., Destrempe, R., Tessier, P., Biochimica et Biophysica Acta - Molecular Basis of Disease, 1991, 10.1016/0925-4439(91)90091-M
  • Activation of Human Neutrophils by Technical Toxaphene, , 1911, http://dx.doi.org/10.1006/clim.2000.4946
  • Induction of neutrophil degranulation by S100A9 via a MAPK-dependent mechanism, , 1911, http://dx.doi.org/10.1016/j.cyto.2009.07.490

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Marc-Antoine Bisson - Maîtrise avec mémoire - En cours
  • Zohra Berrehail - Doctorat - En cours
  • Pier-Olivier Leblanc - Maîtrise avec mémoire - En cours
  • Julie Andrea Chapeton Montes - Maîtrise avec mémoire - 2015/05
  • Nadège Michaud - Doctorat - 2016/01
  • Malika Laouedj - Doctorat - 2017/01
  • Louis-Simon Rousseau - Maîtrise avec mémoire - 2017/09
  • Marie-Pier Longchamps - Maîtrise avec mémoire - 2019/01
  • Joan Defrene - Doctorat - 2020/05

Encadrement d'étudiant(e)s pour les programmes suivants :

*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.