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Centre de recherche du CHU de Québec - Université Laval
Centre de recherche en arthrite (ARThrite)
Partager la fiche :
Contribution à la recherche
Axe de recherche de l'Université Laval :
Santé et bien-être durables
Thématiques de recherche de la Faculté de
médecine :
Immunologie-infectiologie
Oncologie
Domaines et intérêts de recherche du (de la)
professeur(e) :
Appareil locomoteur et arthrite
Peau
Projets de recherche
Developing synthetic S100A9-based molecules for differentiation therapy of human acute myeloid leukemia- Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2022-04-01 au 2027-03-31
Biology of S100A8 and S100A9 proteins in Human Acute Myeloid Leukemia- Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2019-10-01 au 2024-09-30
Surveillance des réponses immunitaires au vaccin contre la COVID-19 chez les personnes vivant avec le VIH-1- Instituts de recherche en santé du Canada - Subvention de fonctionnement:Nouveaux besoins prioritaires en recherche sur la COVID-19, co-chercheur - 2021-12-01 au 2022-11-30
Profil moléculaire sanguin de patientes souffrant de lupus- CHU de Québec – Université Laval – CHUL - Développement de la recherche (RFI), co-chercheur - 2019-04-01 au 2021-03-31
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Publications
Quinoline-3-carboxamides such as tasquinimod are not specific inhibitors of S100A9, Martin Pelletier, Jean-Christophe Simard, Denis Girard, Philippe A. Tessier, Blood Advances, 2018, 10.1182/bloodadvances.2018016667
S100A9 induces differentiation of acute myeloid leukemia cells through TLR4, Malika Laouedj, Mélanie R. Tardif, Laurine Gil, Marie-Astrid Raquil, Asmaa Lachhab, Martin Pelletier, Philippe A. Tessier, Frédéric Barabé, Blood, 2017, 10.1182/blood-2016-09-738005
An Inflammation Loop Orchestrated by S100A9 and Calprotectin Is Critical for Development of Arthritis, Anceriz, N., Cesaro, A., Pagé, N., Plante, A., Tardif, M.R., Tessier, P.A., PLoS ONE, 2012, 10.1371/journal.pone.0045478
Damage-associated molecular pattern S100A9 increases bactericidal activity of human neutrophils by enhancing phagocytosis, Girard, D., Simard, J.-C., Simon, M.-M., Tessier, P.A., Journal of Immunology, 2011, 10.4049/jimmunol.1002956
Induction of neutrophil degranulation by S100A9 via a MAPK-dependent mechanism, Girard, D., Simard, J.-C., Tessier, P.A., Journal of Leukocyte Biology, 2010, 10.1189/jlb.1009676
Surface RANKL of Toll-like receptor 4-stimulated human neutrophils activates osteoclastic bone resorption, Chakravarti, A., Poubelle, P.E., Raquil, M.-A., Tessier, P., Blood, 2009, 10.1182/blood-2008-09-178301
Blockade of antimicrobial proteins S100A8 and S100A9 inhibits phagocyte migration to the alveoli in streptococcal pneumonia, Anceriz, N., Raquil, M.-A., Rouleau, P., Tessier, P.A., Journal of Immunology, 2008
Different expression ratio of S100A8/A9 and S100A12 in acute and chronic lung diseases, Alexis, N.E., Duncan Hite, R., Lorenz, E., Meredith, W., Muhlebach, M.S., Peden, D.B., Seeds, M.C., Tessier, P.A., Respiratory Medicine, 2008, 10.1016/j.rmed.2007.11.011
Localization of S100A8 and S100A9 expressing neutrophils to spinal cord during peripheral tissue inflammation, Iadarola, M.J., Keller, J.M., Mezey, E., Mitchell, K., Muhly, W.T., Swaim, W.D., Szalayova, I., Tessier, P.A., Yang, H.-Y.T., Pain, 2008, 10.1016/j.pain.2007.10.024
Myeloid-related proteins rapidly modulate macrophage nitric oxide production during innate immune response, Olivier, M., Plante, I., Pouliot, P., Raquil, M.-A., Tessier, P.A., Journal of Immunology, 2008
Extracellular nucleotides mediate LPS-induced neutrophil migration in vitro and in vivo, Kukulski, F., Lefebvre, J., Sévigny, J., Tessier, P.A., Warny, M., Yebdri, F.B., Journal of Leukocyte Biology, 2007, 10.1189/jlb.1206758
Immunogenicity of papaya mosaic virus-like particles fused to a hepatitis C virus epitope: Evidence for the critical function of multimerization, Acosta-Ramirez, E., Bedard, M.-C., Bolduc, M., Denis, J., Lacasse, P., Lamarre, A., Lapointe, R., Leclerc, D., Lecours, K., Lopez Macias, C., Majeau, N., Pare, C., Savard, C., Shoukry, N., Simard, S., Tessier, P., Willems, B., Virology, 2007, 10.1016/j.virol.2007.01.011
S100A9 mediates neutrophil adhesion to fibronectin through activation of β2 integrins, Anceriz, N., Tessier, P.A., Vandal, K., Biochemical and Biophysical Research Communications, 2007, 10.1016/j.bbrc.2006.12.203
Evidence for chronic, peripheral activation of neutrophils in polyarticular juvenile rheumatoid arthritis, Cadwell, C., Centola, M., Chen, Y., Dozmorov, I., Frank, M.B., Jarvis, J.N., Jiang, K., Kindzelski, A., McGhee, J.L., Petty, H.R., Szodoray, P., Tang, Y., Tessier, P.A., Turner, M., Arthritis Research and Therapy, 2006, 10.1186/ar2048
Proteomic identification of in vivo substrates for matrix metalloproteinases 2 and 9 reveals a mechanism for resolution of inflammation, Cook, R.G., Corry, D.B., Engler, D.A., Greenlee, K.J., Kheradmand, F., Matsunami, R.K., Tessier, P., Werb, Z., Journal of Immunology, 2006
S100A8 and S100A9 activate MAP kinase and NF-κB signaling pathways and trigger translocation of RAGE in human prostate cancer cells, De Servi, B., Hermani, A., Mayer, D., Medunjanin, S., Tessier, P.A., Experimental Cell Research, 2006, 10.1016/j.yexcr.2005.10.013
S100A8 chemotactic protein is abundantly increased, but only a minor contributor to LPS-induced, steroid resistant neutrophilic lung inflammation in vivo, Anderson, G.P., Bozinovski, S., Cross, M., Geczy, C.L., Hamilton, J.A., Hsuu, K., Hume, D.A., Jones, J.E., Reynolds, E.C., Tessier, P.A., Vlahos, R., Journal of Proteome Research, 2005, 10.1021/pr049829t
Hemozoin-Inducible Proinflammatory Events In Vivo: Potential Role in Malaria Infection, Jaramillo, M., Olivier, M., Ouellet, N., Plante, I., Tessier, P.A., Vandal, K., Journal of Immunology, 2004
Monosodium urate monohydrate crystals induce the release of the proinflammatory protein S100A8/A9 from neutrophils, De Médicis, R., Gilbert, C., Lussier, A., Ryckman, C., Tessier, P.A., Vandal, K., Journal of Leukocyte Biology, 2004, 10.1189/jlb.0603294
Toll-like receptor 2 represses nonpilus adhesin-induced signaling in acute infections with the Pseudomonas aeruginosa pilA mutant, Chemotti, D.C., Lorenz, E., Tessier, P.A., Vandal, K., Infection and Immunity, 2004, 10.1128/IAI.72.8.4561-4569.2004
Blockade of S100A8 and S100A9 suppresses neutrophil migration in response to lipopolysaccharide, Boivin, A., Rouleau, P., Ryckman, C., Talbot, M., Tessier, P.A., Vandal, K., Journal of Immunology, 2003
Proinflammatory activities of S100: Proteins S100A8, S100A9, and S100A8/A9 induce neutrophil chemotaxis and adhesion, Rouleau, P., Ryckman, C., Talbot, M., Tessier, P.A., Vandal, K., Journal of Immunology, 2003
Role of S100A8 and S100A9 in neutrophil recruitment in response to monosodium urate monohydrate crystals in the air-pouch model of acute gouty arthritis, De Médicis, R., Lussier, A., McColl, S.R., Poubelle, P.E., Ryckman, C., Tessier, P.A., Vandal, K., Arthritis and Rheumatism, 2003, 10.1002/art.11079
The calcium-binding protein S100A12 induces neutrophil adhesion, migration, and release from bone marrow in mouse at concentrations similar to those found in human inflammatory arthritis, Boivin, A., Poubelle, P.E., Rouleau, P., Ryckman, C., Talbot, M., Tessier, P.A., Vandal, K., Clinical Immunology, 2003, 10.1016/S1521-6616(02)00043-8
HIV-1 transcription and virus production- are both accentuated by the proinflammatory myeloid-related proteins in human CD4+ T lymphocytes, Cantin, R., Robichaud, G.A., Roy, J., Ryckman, C., Tessier, P.A., Tremblay, M.J., Journal of Immunology, 2002
The S100 family heterodimer, MRP-8/14, binds with high affinity to heparin and heparan sulfate glycosaminoglycans on endothelial cells, Hogg, N., Poulsom, R., Robinson, M.J., Tessier, P., Journal of Biological Chemistry, 2002, 10.1074/jbc.M102950200
Activation of human neutrophils in vitro and dieldrin-induced neutrophilic inflammation in vivo, Gauthier, M., Girard, D., Pelletier, M., Roberge, C.J., Tessier, P.A., Vandal, K., Journal of Leukocyte Biology, 2001
The use of lymphocyte function-associated antigen (LFA)-1-deficient mice to determine the role of LFA-1, Mac-1, and α4 integrin in the inflammatory response of neutrophils, Gavins, F.N.E., Henderson, R.B., Hogg, N., Lim, L.H.K., Mathies, M., Perretti, M., Tessier, P.A., Journal of Experimental Medicine, 2001, 10.1084/jem.194.2.219
Induction of acute inflammation in vivo by staphylococcal superantigens I: Leukocyte recruitment occurs independently of T lymphocytes and major histocompatibility complex class II molecules, Diener, K., Fraser, J., Königen, F., McColl, S.R., Tessier, P., Laboratory Investigation, 1998
Induction of acute inflammation in vivo by staphylococcal superantigens. II. Critical role for chemokines, ICAM-1, and TNF-α, Clark-Lewis, I., Diener, K.R., Gladue, R.P., McColl, S.R., Naccache, P.H., Neote, K.S., Tessier, P.A., Journal of Immunology, 1998
Chemokine Networks in Vivo: Involvement of C-X-C and C-C Chemokines in Neutrophil Extravasation in Vivo in Response to TNF-α, Clark-Lewis, I., Gladue, R.P., McColl, S.R., Naccache, P.H., Neote, K.S., Tessier, P.A., Journal of Immunology, 1997
Inhibition of lymphocyte adhesion to cytokine-activated synovial fibroblasts by glucocorticoids involves the attenuation of vascular cell adhesion molecule 1 and intercellular adhesion molecule 1 gene expression, Cattaruzzi, P., McColl, S.R., Tessier, P.A., Arthritis and Rheumatism, 1996
Up-regulation by tumor necrosis factor α of intercellular adhesion molecule 1 expression and function in synovial fibroblasts and its inhibition by glucocorticoids, Audette, M., Cattaruzzi, P., McColl, S.R., Tessier, P., Arthritis and Rheumatism, 1993, 10.1002/art.1780361107
Regulation by retinoic acid of ICAM-1 expression on human tumor cell lines, Audette, M., Bouillon, M., Boulianne, R., Destrempe, R., Tessier, P., Biochimica et Biophysica Acta - Molecular Basis of Disease, 1991, 10.1016/0925-4439(91)90091-M
Activation of Human Neutrophils by Technical Toxaphene, , 1911, http://dx.doi.org/10.1006/clim.2000.4946
Induction of neutrophil degranulation by S100A9 via a MAPK-dependent mechanism, , 1911, http://dx.doi.org/10.1016/j.cyto.2009.07.490
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Contribution à l'enseignement aux cycles supérieurs
Étudiant(e)s dirigé(e)s*
Depuis 2009
Marc-Antoine Bisson - Maitrîse avec mémoire - En cours
Zohra Berrehail - Doctorat - En cours
Pier-Olivier Leblanc - Maitrîse avec mémoire - En cours
Julie Andrea Chapeton Montes - Maitrîse avec mémoire - 2015/05
Nadège Michaud - Doctorat - 2016/01
Malika Laouedj - Doctorat - 2017/01
Louis-Simon Rousseau - Maitrîse avec mémoire - 2017/09
Marie-Pier Longchamps - Maitrîse avec mémoire - 2019/01
Joan Defrene - Doctorat - 2020/05
Encadrement d'étudiant(e)s pour les programmes suivants :
*Les supervisions d’étudiant(e)s de 1er cycle en
stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées
ultérieurement.
Vice-décanat à la recherche et aux études supérieures Pavillon Ferdinand-Vandry Université Laval 1050, avenue de la Médecine, local 4645 Québec (Québec) G1V 0A6 Canada
Catherine Comtois Agente de gestion des études etudes.sup2@fmed.ulaval.ca Biostatistique Épidémiologie Évaluation économique des technologies de la santé Santé publique
Marianne Rivest et Claudia Gonzalez Agentes de gestion des études etudes.sup1@fmed.ulaval.ca Biologie cellulaire et moléculaire Génomique fonctionnelle Médecine moléculaire Microbiologie-immunologie Neurosciences
Isabelle Tremblay Agente de gestion des études etudes.sup3@fmed.ulaval.ca Pédagogie universitaire en sciences de la santé Sciences cliniques et biomédicales Sciences de la réadaptation Prévention et gestion de la santé et de la sécurité au travail