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Mohsen Agharazii

Médecin clinicien enseignant titulaire

Mohsen Agharazii
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Santé cardiovasculaire, respiratoire et métabolisme

Domaines et intérêts de recherche du (de la) professeur(e) :

Nutrition et métabolisme
  • Désordres métaboliques
  • Maladies rénales
  • Système rénal
  • Insuffisance rénale et malabsorption
Santé circulatoire et respiratoire
  • Système cardiovasculaire
  • Hypertension artérielle
Vieillissement

Projets de recherche

  • Identifying low bone turnover disease in chronic kidney disease in order to guide anti-fracture therapy - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2020-10-01 au 2025-09-30
  • Early Prediction of preeclampsia Using arteriaL Stiffness in high-risk prEgnancies; a multinational study (PULSE) - Instituts de recherche en santé du Canada - Subvention Projet, McGill University, co-chercheur - 2020-04-01 au 2025-03-31
  • Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
  • Arterial stiffness gradient as a new index of vascular aging: impact of blood pressure lowering medication - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2019-10-01 au 2024-09-30
  • Characterizing Cardiovascular Outcomes in Subclinical Primary Aldosteronism - Instituts de recherche en santé du Canada - Subvention Projet, Institut de recherche de l'Hôpital d'Ottawa, co-chercheur - 2021-04-01 au 2024-03-31
  • Accelerated CKD-related vascular calcification: Role of thiazide-type, thiazide-like and loop diuretics - Fondation canadienne du rein, chercheur principal - 2020-10-01 au 2022-09-30
  • Covid-19 effects on ARTErial StIffness and vascular AgiNg (CARTESIAN) study- Canada - Instituts de recherche en santé du Canada - Subvention de fonctionnement : Possibilité de financement sur les nouveaux besoins prioritaires en recherche sur la COVID-19, chercheur principal - 2021-06-01 au 2022-05-31
  • Non-invasive measurement of arterial stiffness of microcirculation in humans: an integrated approach - Fondation de l'Université Laval, chercheur principal - 2020-01-20 au 2022-04-30
  • Mécanismes de la rigidité aortique en insuffisance rénale chez l'humain - Fondation de l'Université Laval, chercheur principal - 2018-06-01 au 2022-04-30
  • Traiter l’os pour prévenir l’hypertension et les maladies cardiovasculaires chez les femmes ménopausées. - Alliance santé Québec (AsQ), chercheur principal - 2021-05-01 au 2022-04-30
  • Cardiovascular and renal therapeutic effects of the ferric pyrophosphate citrate (FPC) Triferic® in rats with chronic kidney disease - Rockwell Medical, co-chercheur - 2020-09-09 au 2021-10-31
  • Impact du travail sur la maladie rénale - Fondation de l'Université Laval, chercheur principal - 2017-05-01 au 2021-04-30
  • Progression des altérations structurelles et biomécaniques des artères centrales et périphériques en insuffisance rénale chronique et prix Louis Belleau - Fondation de l'Université Laval, chercheur principal - 2016-04-01 au 2020-12-31
  • Optimisation et évaluation des patients en insuffisance rénale chronique - Fondation du CHU de Québec, chercheur principal - 2019-10-10 au 2020-10-09
  • Chaire de recherche en néphrologie Amgen - Fondation de l'Université Laval, chercheur principal - 2015-01-01 au 2019-12-31

Publications

  • Inaccuracy of brachial blood pressure and its potential impact on treatment and aortic blood pressure estimation., , Journal of hypertension, 2021, 10.1097/hjh.0000000000002943
  • Health literacy level in a various nephrology population from Québec: predialysis clinic, in-centre hemodialysis and home dialysis; a transversal monocentric observational study., , BMC nephrology, 2021, 10.1186/s12882-021-02464-1
  • Feasibility of an Intradialytic Combined Exercise Program Targeting Older Adults With End-Stage Renal Disease., , Journal of aging and physical activity, 2021, 10.1123/japa.2020-0359
  • Coagulation anomalies, endothelial dysfunction, and aortic stiffness., , Kidney international, 2021, 10.1016/j.kint.2021.01.020
  • Effects of living kidney donation on arterial stiffness: a systematic review protocol., , BMJ open, 2021, 10.1136/bmjopen-2020-045518
  • Radial-digital pulse wave velocity: a noninvasive method for assessing stiffness of small conduit arteries., , American journal of physiology. Heart and circulatory physiology, 2021, 10.1152/ajpheart.00551.2020
  • Prediction of Cardiovascular Events by Type I Central Systolic Blood Pressure: A Prospective Study., , Hypertension (Dallas, Tex. : 1979), 2020, 10.1161/hypertensionaha.120.16163
  • Association of Glomerular Hyperfiltration and Cardiovascular Risk in Middle-Aged Healthy Individuals., , JAMA network open, 2020, 10.1001/jamanetworkopen.2020.2377
  • Pharmacologic Therapies for Aortic Stiffness in End-Stage Renal Disease: A Systematic Review and Meta-Analysis., , Canadian journal of kidney health and disease, 2020, 10.1177/2054358120906974
  • Determinants of Increased Central Excess Pressure in Dialysis: Role of Dialysis Modality and Arteriovenous Fistula., , American journal of hypertension, 2020, 10.1093/ajh/hpz136
  • Sodium and urea excretion as determinants of urine output in autosomal dominant polycystic kidney disease patients on V2 receptor antagonists: impact of dietary intervention, Gabrielle Côté, Lori Asselin-Thompstone, Fabrice Mac-Way, Paul René de Cotret, Christine Lacroix, Simon Desmeules, Mohsen Agharazii, International Urology and Nephrology, 2020, 10.1007/s11255-020-02384-3
  • A Systematic Review and Meta-analysis of Nonpharmacologic-based Interventions for Aortic Stiffness in End-Stage Renal Disease., , Kidney international reports, 2019, 10.1016/j.ekir.2019.05.011
  • Blood Pressure Measurement in Severely Obese Patients: Validation of the Forearm Approach in Different Arm Positions., , American journal of hypertension, 2019, 10.1093/ajh/hpy152
  • An Adjustable Dalteparin Sodium Dose Regimen for the Prevention of Clotting in the Extracorporeal Circuit in Hemodialysis: A Clinical Trial of Safety and Efficacy (the PARROT Study)., , Canadian journal of kidney health and disease, 2018, 10.1177/2054358118809104
  • FGF23-klotho axis, bone fractures, and arterial stiffness in dialysis: a case-control study., , Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2018, 10.1007/s00198-018-4598-2
  • Pulse Wave Velocity and Prognosis in End-Stage Kidney Disease., , Hypertension (Dallas, Tex. : 1979), 2018, 10.1161/hypertensionaha.118.10930
  • High calcium, phosphate and calcitriol supplementation leads to an osteocyte-like phenotype in calcified vessels and bone mineralisation defect in uremic rats., , Journal of bone and mineral metabolism, 2018, 10.1007/s00774-018-0919-y
  • Uric acid association with pulsatile and steady components of central and peripheral blood pressures., , Journal of hypertension, 2018, 10.1097/hjh.0000000000001573
  • Central and Brachial Blood Pressures, Statins, and Low-Density Lipoprotein Cholesterol: A Mediation Analysis., , Hypertension (Dallas, Tex. : 1979), 2018, 10.1161/hypertensionaha.117.10476
  • Association of interleukin-6 with aortic stiffness in end-stage renal disease, Marie-Pier Desjardins, Aboubacar Sidibé, Catherine Fortier, Fabrice Mac-Way, Karine Marquis, Sacha De Serres, Richard Larivière, Mohsen Agharazii, Journal of the American Society of Hypertension, 2018, 10.1016/j.jash.2017.09.013
  • Reduction of Arterial Stiffness After Kidney Transplantation: A Systematic Review and Meta-Analysis., , Journal of the American Heart Association, 2017, 10.1161/jaha.117.007235
  • IL-6 production by monocytes is associated with graft function decline in patients with borderline changes suspicious for acute T-cell-mediated rejection: a pilot study., , Transplant international : official journal of the European Society for Organ Transplantation, 2017, 10.1111/tri.13070
  • Central blood pressures in early chronic kidney disease: an analysis of CARTaGENE., , Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2017, 10.1093/ndt/gfw059
  • Acute effects of cinacalcet on arterial stiffness and ventricular function in hemodialysis patients: A randomized double-blinded crossover study., , Medicine, 2017, 10.1097/md.0000000000006912
  • Prediction and validation of the duration of hemodialysis sessions for the treatment of acute ethylene glycol poisoning., Iliuta IA, Lachance P, Ghannoum M, Bégin Y, Mac-Way F, Desmeules S, De Serres SA, Julien AS, Douville P, Agharazii M, 2017, 10.1016/j.kint.2017.02.018
  • Endothelin type A receptor blockade reduces vascular calcification and inflammation in rats with chronic kidney disease., Larivière R, Gauthier-Bastien A, Ung RV, St-Hilaire J, Mac-Way F, Richard DE, Agharazii M, 2017, 10.1097/hjh.0000000000001161
  • Levels of Angiopoietin-Like-2 Are Positively Associated With Aortic Stiffness and Mortality After Kidney Transplantation., Desjardins MP, Thorin-Trescases N, Sidibé A, Fortier C, De Serres SA, Larivière R, Thorin E, Agharazii M, 2017, 10.1093/ajh/hpw208
  • Aortic-Brachial Pulse Wave Velocity Ratio: A Blood Pressure-Independent Index of Vascular Aging., Fortier C, Sidibé A, Desjardins MP, Marquis K, De Serres SA, Mac-Way F, Agharazii M, 2017, 10.1161/hypertensionaha.116.08409
  • Aortic-Brachial Pulse Wave Velocity Ratio: A Measure of Arterial Stiffness Gradient Not Affected by Mean Arterial Pressure, Catherine Fortier, Marie-Pier Desjardins, Mohsen Agharazii, Pulse, 2017, 10.1159/000480092
  • Hypoxia-inducible factor-1 plays a role in phosphate-induced vascular smooth muscle cell calcification., Mokas S, Larivière R, Lamalice L, Gobeil S, Cornfield DN, Agharazii M, Richard DE, 2016, 10.1016/j.kint.2016.05.020
  • Heart rate dependent and independent effects of beta-blockers on central hemodynamic parameters: a propensity score analysis., Goupil R, Dupuis D, Troyanov S, Madore F, Agharazii M, 2016, 10.1097/hjh.0000000000000978
  • 2013 Banff Criteria for Chronic Active Antibody-Mediated Rejection: Assessment in a Real-Life Setting., De Serres SA, Noël R, Côté I, Lapointe I, Wagner E, Riopel J, Latulippe E, Agharazii M, Houde I, 2016, 10.1111/ajt.13624
  • Advanced chronic kidney disease populations have elevated trimethylamine N-oxide levels associated with increased cardiovascular events., Kim RB, Morse BL, Djurdjev O, Tang M, Muirhead N, Barrett B, Holmes DT, Madore F, Clase CM, Rigatto C, Levin A, CanPREDDICT Investigators, 2016, 10.1016/j.kint.2016.01.014
  • Arterial Stiffness Gradient., Fortier C, Agharazii M, 2016, 10.1159/000438852
  • Prediction and validation of hemodialysis duration in acute methanol poisoning., Lachance P, Mac-Way F, Desmeules S, De Serres SA, Julien AS, Douville P, Ghannoum M, Agharazii M, 2015, 10.1038/ki.2015.232
  • 4D.07: ENDOTHELIN A RECEPTOR BLOCKADE REDUCES VASCULAR CALCIFICATION IN RATS WITH CHRONIC KIDNEY DISEASE AND MINERAL DISORDERS., Agharazii M, Gauthier-Bastien A, Ung RV, Mac-Way F, Richard D, Lariviere R, 2015, 10.1097/01.hjh.0000467511.21263.68
  • Inflammatory cytokines and reactive oxygen species as mediators of chronic kidney disease-related vascular calcification., Agharazii M, St-Louis R, Gautier-Bastien A, Ung RV, Mokas S, Larivière R, Richard DE, 2015, 10.1093/ajh/hpu225
  • Aortic-brachial stiffness mismatch and mortality in dialysis population., Fortier C, Mac-Way F, Desmeules S, Marquis K, De Serres SA, Lebel M, Boutouyrie P, Agharazii M, 2015, 10.1161/hypertensionaha.114.04587
  • Donor-specific antibodies, C4d and their relationship with the prognosis of transplant glomerulopathy., Lesage J, Noël R, Lapointe I, Côté I, Wagner E, Désy O, Caumartin Y, Agharazii M, Batal I, Houde I, De Serres SA, 2015, 10.1097/tp.0000000000000310
  • Effectiveness of Haemodiafiltration with Heat Sterilized High-Flux Polyphenylene HF Dialyzer in Reducing Free Light Chains in Patients with Myeloma Cast Nephropathy., Rousseau-Gagnon M, Agharazii M, De Serres SA, Desmeules S, 2015, 10.1371/journal.pone.0140463
  • Active vitamin D and accelerated progression of aortic stiffness in hemodialysis patients: a longitudinal observational study., Fortier C, Mac-Way F, De Serres SA, Marquis K, Douville P, Desmeules S, Larivière R, Agharazii M, 2014, 10.1093/ajh/hpu057
  • The impact of warfarin on the rate of progression of aortic stiffness in hemodialysis patients: a longitudinal study., Mac-Way F, Poulin A, Utescu MS, De Serres SA, Marquis K, Douville P, Desmeules S, Larivière R, Lebel M, Agharazii M, 2014, 10.1093/ndt/gfu224
  • Biomarkers of inflammation, fibrosis, cardiac stretch and injury predict death but not renal replacement therapy at 1 year in a Canadian chronic kidney disease cohort., Levin A, Rigatto C, Barrett B, Madore F, Muirhead N, Holmes D, Clase CM, Tang M, Djurdjev O, CanPREDDICT Investigators, 2014, 10.1093/ndt/gft479
  • Advanced glycation end products, aortic stiffness, and wave reflection in peritoneal dialysis as compared to hemodialysis., Mac-Way F, Couture V, Utescu MS, Ignace S, De Serres SA, Loignon RC, Marquis K, Larivière R, Agharazii M, 2014, 10.1007/s11255-013-0597-6
  • Determinants of progression of aortic stiffness in hemodialysis patients: a prospective longitudinal study., Utescu MS, Couture V, Mac-Way F, De Serres SA, Marquis K, Larivière R, Desmeules S, Lebel M, Boutouyrie P, Agharazii M, 2013, 10.1161/hypertensionaha.113.01200
  • Cohort profile: Canadian study of prediction of death, dialysis and interim cardiovascular events (CanPREDDICT)., Levin A, Rigatto C, Brendan B, Madore F, Muirhead N, Holmes D, Clase CM, Tang M, Djurdjev O, CanPREDDICT investigators, 2013, 10.1186/1471-2369-14-121
  • Gemella sanguinis endocarditis with c-ANCA/anti-PR-3-associated immune complex necrotizing glomerulonephritis with a 'full-house' pattern on immunofluorescence microscopy., Rousseau-Gagnon M, Riopel J, Desjardins A, Garceau D, Agharazii M, Desmeules S, 2013, 10.1093/ckj/sft030
  • eNOS gene delivery prevents hypertension and reduces renal failure and injury in rats with reduced renal mass., , Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2011, 10.1093/ndt/gfr641
  • RAGE-dependent activation of the oncoprotein Pim1 plays a critical role in systemic vascular remodeling processes., , Arteriosclerosis, thrombosis, and vascular biology, 2011, 10.1161/atvbaha.111.230573
  • Arterial stiffness and dialysis calcium concentration., , International journal of nephrology, 2011, 10.4061/2011/839793
  • Impact of dialysate calcium concentration on the progression of aortic stiffness in patients on haemodialysis., , Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2011, 10.1093/ndt/gfr138
  • Dual-kidney transplants as an alternative for very marginal donors: long-term follow-up in 63 patients., , Transplantation, 2010, 10.1097/tp.0b013e3181f8f2b8
  • Tumor necrosis factor inhibitors as novel therapeutic tools for vascular remodeling diseases., , American journal of physiology. Heart and circulatory physiology, 2010, 10.1152/ajpheart.00562.2010
  • Role of oxidative stress in erythropoietin-induced hypertension in uremic rats., , American journal of hypertension, 2009, 10.1038/ajh.2009.242
  • Effects of acute variation of dialysate calcium concentrations on arterial stiffness and aortic pressure waveform., , Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2009, 10.1093/ndt/gfp351
  • The impact of arteriovenous fistulas on aortic stiffness in patients with chronic kidney disease., , Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2009, 10.1093/ndt/gfp276
  • Impact of age on glomerular filtration estimates., , Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2008, 10.1093/ndt/gfn473
  • Incidence and severity of early electrolyte abnormalities following autologous haematopoietic stem cell transplantation., , Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2007, 10.1093/ndt/gfm571
  • Local shear stress and brachial artery functions in end-stage renal disease., , Journal of the American Society of Nephrology : JASN, 2007, 10.1681/asn.2006040400
  • Antihypertensive and renal protective effects of renin-angiotensin system blockade in uremic rats treated with erythropoietin., , American journal of hypertension, 2006, 10.1016/j.amjhyper.2006.06.019
  • Green dialysate: asymptomatic perforated cholecystitis without peritonitis., , Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2006, 10.1093/ndt/gfk099
  • In vivo quantification of central venous catheter leak., , Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2005, 10.1093/ndt/gfi247
  • Nonfasting non-high-density lipoprotein cholesterol is adequate for lipid management in hemodialysis patients., , American journal of kidney diseases : the official journal of the National Kidney Foundation, 2005, 10.1053/j.ajkd.2005.03.002
  • Estimation of heparin leak into the systemic circulation after central venous catheter heparin lock., , Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2005, 10.1093/ndt/gfh841
  • Systolic blood pressure diurnal variation is not a predictor of renal target organ damage in kidney transplant recipients., , American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2004, 10.1046/j.1600-6143.2003.00326.x
  • What added value does ambulatory blood pressure monitoring brings to the management of post renal transplantation hypertension?, , Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi, 2003
  • Continuous veno-venous hemodiafiltration for the treatment of spontaneous tumor lysis syndrome complicated by acute renal failure and severe hyperuricemia., , Clinical nephrology, 2000
  • 2,8-Dihydroxyadeninuria-induced progressive renal failure, , 1911, http://dx.doi.org/10.1093/ndtplus/sfn110
  • Age-related and blood pressure-independent reduction in aortic stiffness after kidney transplantation, , 1911, http://dx.doi.org/10.1097/hjh.0b013e32833f5e68
  • Arterial and renal consequences of partial genetic deficiency in tissue kallikrein activity in humans, , 1911, http://dx.doi.org/10.1172/jci23669
  • Captopril Suppression Versus Salt Loading in Confirming Primary Aldosteronism, , 1911, http://dx.doi.org/10.1161/01.hyp.37.6.1440
  • Chronic Interstitial Nephritis due to 5-Aminosalicylic Acid, , 1911, http://dx.doi.org/10.1159/000013480
  • Endothelial Function and Chronic Exposure to Air Pollution in Normal Male Subjects, , 1911, http://dx.doi.org/10.1161/hypertensionaha.107.095844
  • Forearm reactive hyperemia and mortality in end-stage renal disease, , 1911, http://dx.doi.org/10.1111/j.1523-1755.2004.00434.x
  • Impact of donor age on long-term outcomes after delayed graft function: 10-year follow-up, , 1911, http://dx.doi.org/10.1111/tri.12016
  • Insights from ambulatory blood pressure monitoring: diagnosis of hypertension and diurnal blood pressure in renal transplant recipients, , 1911, http://dx.doi.org/10.1097/01.tp.0000115345.16853.51
  • Linezolid-Associated Acute Interstitial Nephritis and Drug Rash With Eosinophilia and Systemic Symptoms (DRESS) Syndrome, , 1911, http://dx.doi.org/10.1053/j.ajkd.2009.07.013
  • Morning Plasma Aldosterone Predicts the Subtype of Primary Aldosteronism Independant of Sodium Intake, , 1911, http://dx.doi.org/10.1080/10641960701195520
  • Neutralization of transforming growth factor-b attenuates hypertension and prevents renal injury in uremic rats, , 1911, http://dx.doi.org/10.1097/01.hjh.0000182521.44440.c5
  • Neutralization of Tumor Necrosis Factor-Alpha Reduces Renal Fibrosis and Hypertension in Rats with Renal Failure, , 1911, http://dx.doi.org/10.1159/000340033
  • Protective effects of angiotensin AT1 receptor blockade in malignant hypertension in the rat, , 1911, http://dx.doi.org/10.1016/j.ejphar.2009.01.040
  • The mystery of the recirculating dialysis catheter, , 1911, http://dx.doi.org/10.1038/ki.2008.144
  • Variation of Intra-Access Flow Early and Late into Hemodialysis, , 1911, http://dx.doi.org/10.1097/00002480-200007000-00017
  • Vascular remodeling and media calcification increases arterial stiffness in chronic kidney disease, , 1911, http://dx.doi.org/10.3109/10641963.2013.804541

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Sophie Mokas - Doctorat - En cours
  • Catherine Fortier - Post-doctorat - En cours
  • Younes Srour - Maitrîse avec mémoire - En cours
  • Charles-Antoine Garneau - Maitrîse avec mémoire - En cours
  • Mathilde Paré - Maitrîse avec mémoire - En cours
  • Hasan Obeid - Post-doctorat - En cours
  • Nadège Côté - Maitrîse avec mémoire - En cours
  • Jean-Philippe Leconte - Maitrîse avec mémoire - 2013/09
  • Alexandra Gauthier Bastien - Maitrîse avec mémoire - 2014/01
  • Yue Pei Wang - Maitrîse avec mémoire - 2019/09

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.

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Vice-décanat à la recherche et aux études supérieures
Pavillon Ferdinand-Vandry
Université Laval
1050, avenue de la Médecine,  local 4645
Québec, Québec G1V 0A6
Canada

Renseignements - Secrétariat :
vdres@fmed.ulaval.ca

Jacques Simard
Vice-doyen à la recherche et aux études supérieures
vice-doyen.recherche-et-etudes-superieures@fmed.ulaval.ca

Louise Laperrière
Adjointe au vice-doyen à la recherche et aux études supérieures
louise.laperriere@fmed.ulaval.ca 

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