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Centre de recherche du CHU de Québec - Université Laval
Partager la fiche :
Contribution à la recherche
Axe de recherche de l'Université Laval :
Santé et bien-être durables
Thématiques de recherche de la Faculté de
médecine :
Oncologie
Domaines et intérêts de recherche du (de la)
professeur(e) :
Cancer
Génétique du cancer
Signalisation cellulaire et cancer
Diagnostic et détection du cancer
Projets de recherche
Understanding the regulation and implication of Argonaute in microRNA-mediated gene silencing.- Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2020-10-01 au 2025-09-30
Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval- Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
Genetic and molecular analysis of the siRNA-mediated gene regulation- Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC), Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2019-04-01 au 2024-03-31
Canadian Developmental Biology Conference 2023- Instituts de recherche en santé du Canada - Programme d'’appui communautaire des instituts (PACI), co-chercheur - 2021-04-01 au 2023-03-31
Acquisition d'un appareil PCR pour analyses d'échantillons biologiques - Fondation du CHU de Québec, chercheur principal - 2021-07-16 au 2022-07-15
Étude de la régulation des gènes par les courts ARNs non-codants- Fonds de recherche du Québec - Santé - Chaires de recherche FRQS, chercheur principal - 2017-07-01 au 2021-06-30
Soutien salarial d'un professeur- CHU de Québec – Université Laval – Hôpital Hôtel-Dieu-de-Québec, CHUQ - Hôpital Hôtel-Dieu de Québec --- utiliser sirul no. 7695, chercheur principal - 2006-07-01 au 2021-06-30
Functional dissection of the microRNA pathway.- Instituts de recherche en santé du Canada - Subvention de fonctionnement, chercheur principal - 2015-07-01 au 2021-03-31
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Publications
Regulation and different functions of the animal microRNA‐induced silencing complex, Pierre‐Marc Frédérick, Martin J. Simard, WIREs RNA, 2021, 10.1002/wrna.1701
CSDE1 attenuates microRNA-mediated silencing of PMEPA1 in melanoma, Pavan Kumar Kakumani, Tanit Guitart, Francois Houle, Louis-Mathieu Harvey, Benjamin Goyer, Lucie Germain, Fátima Gebauer, Martin J. Simard, Oncogene, 2021, 10.1038/s41388-021-01767-9
The RabGAP TBC-11 controls Argonaute localization for proper microRNA function in C. elegans, Pascale Michaud, Vivek Nilesh Shah, Pauline Adjibade, Francois Houle, Miguel Quévillon Huberdeau, Rachel Rioux, Camille Lavoie-Ouellet, Weifeng Gu, Rachid Mazroui, Martin J. Simard, PLOS Genetics, 2021, 10.1371/journal.pgen.1009511
CSDE1 controls gene expression through the miRNA-mediated decay machinery, Pavan Kumar Kakumani, Louis-Mathieu Harvey, François Houle, Tanit Guitart, Fátima Gebauer, Martin J Simard, Life Science Alliance, 2020, 10.26508/lsa.201900632
A guide to micro RNA ‐mediated gene silencing, Miguel Quévillon Huberdeau, Martin J. Simard, The FEBS Journal, 2019, 10.1111/febs.14666
p38 activation induces production of miR-146a and miR-31 to repress E-selectin expression and inhibit transendothelial migration of colon cancer cells, Liang Zhong, Jacques Huot, Martin J. Simard, Scientific Reports, 2018, 10.1038/s41598-018-20837-9
Somatic and Germline MicroRNAs Form Distinct Silencing Complexes to Regulate Their Target mRNAs Differently, Alexandra Dallaire, Pierre-Marc Frédérick, Martin J. Simard, Developmental Cell, 2018, 10.1016/j.devcel.2018.08.022
Biogenesis of small non-coding RNAs in animals | La biogenèse des ARN courts non codants chez les animaux, Fressigné, L., Simard, M.J., Medecine/Sciences, 2018, 10.1051/medsci/20183402011
P38 and JNK pathways control E-selectin-dependent extravasation of colon cancer cells by modulating miR-31 transcription, Zhong, L., Simoneau, B., Huot, J., Simard, M.J., Oncotarget, 2017, 10.18632/oncotarget.13779
Phosphorylation of Argonaute proteins affects mRNA binding and is essential for microRNA-guided gene silencing in vivo, Quévillon Huberdeau, M., Zeitler, D.M., Hauptmann, J., Bruckmann, A., Fressigné, L., Danner, J., Piquet, S., Strieder, N., Engelmann, J.C., Jannot, G., Deutzmann, R., Simard, M.J., Meister, G., EMBO Journal, 2017, 10.15252/embj.201696386
TEG-1 CD2BP2 controls miRNA levels by regulating miRISC stability in C. elegans and human cells, Wang, C., Gupta, P., Fressigne, L., Bossé, G.D., Wang, X., Simard, M.J., Hansen, D., Nucleic acids research, 2017, 10.1093/nar/gkw836
GW182-Free microRNA Silencing Complex Controls Post-transcriptional Gene Expression during Caenorhabditis elegans Embryogenesis, Jannot, G., Michaud, P., Quévillon Huberdeau, M., Morel-Berryman, L., Brackbill, J.A., Piquet, S., McJunkin, K., Nakanishi, K., Simard, M.J., PLoS Genetics, 2016, 10.1371/journal.pgen.1006484
Poly(A)-binding proteins are required for microRNA-mediated silencing and to promote target deadenylation in C. elegans, Flamand, M.N., Wu, E., Vashisht, A., Jannot, G., Keiper, B.D., Simard, M.J., Wohlschlegel, J., Duchaine, T.F., Nucleic Acids Research, 2016, 10.1093/nar/gkw276
The implication of microRNAs and endo-siRNAs in animal germline and early development, Dallaire, A., Simard, M.J., Developmental Biology, 2016, 10.1016/j.ydbio.2016.06.007
MicroRNA-19a enhances proliferation of bronchial epithelial cells by targeting TGFβR2 gene in severe asthma, Haj-Salem, I., Fakhfakh, R., Bérubé, J.-C., Jacques, E., Plante, S., Simard, M.J., Bossé, Y., Chakir, J., Allergy: European Journal of Allergy and Clinical Immunology, 2015, 10.1111/all.12551
The human decapping scavenger enzyme DcpS modulates microRNA turnover, Meziane, O., Piquet, S., Bossé, G.D., Gagné, D., Paquet, E., Robert, C., Tones, M.A., Simard, M.J., Scientific Reports, 2015, 10.1038/srep16688
Expression profile of Caenorhabditis elegans mutant for the Werner syndrome gene ortholog reveals the impact of vitamin C on development to increase life span, Dallaire, A., Proulx, S., Simard, M.J., Lebel, M., BMC Genomics, 2014, 10.1186/1471-2164-15-940
Mutations in Conserved Residues of the C. elegans microRNA Argonaute ALG-1 Identify Separable Functions in ALG-1 miRISC Loading and Target Repression, Zinovyeva, A.Y., Bouasker, S., Simard, M.J., Hammell, C.M., Ambros, V., PLoS Genetics, 2014, 10.1371/journal.pgen.1004286
A New Role for the GARP Complex in MicroRNA-Mediated Gene Regulation, Vasquez-Rifo, A., Bossé, G.D., Rondeau, E.L., Jannot, G., Dallaire, A., Simard, M.J., PLoS Genetics, 2013, 10.1371/journal.pgen.1003961
Next-generation biobanking of metastases to enable multidimensional molecular profiling in personalized medicine, Diaz, Z., Aguilar-Mahecha, A., Paquet, E.R., Basik, M., Orain, M., Camlioglu, E., Constantin, A., Benlimame, N., Bachvarov, D., Jannot, G., Simard, M.J., Chabot, B., Gologan, A., Klinck, R., Gagnon-Kugler, T., Lespérance, B., Samson, B., Kavan, P., Alcindor, T., Dalfen, R., Lan, C., Chabot, C., Buchanan, M., Przybytkowrski, E., Qureshi, S., Rousseau, C., Spatz, A., Têtu, B., Batist, G., Modern Pathology, 2013, 10.1038/modpathol.2013.81
The decapping scavenger enzyme DCS-1: A new modulator of miRNA turnover, Meziane, O., Bossé, G.D., Simard, M.J., Cell Cycle, 2013, 10.4161/cc.26076
Annexin-1-mediated endothelial cell migration and angiogenesis are regulated by vascular endothelial growth factor (VEGF)-induced inhibition of miR-196a expression, Pin, A.-L., Houle, F., Fournier, P., Guillonneau, M., Paquet, É.R., Simard, M.J., Royal, I., Huot, J., Journal of Biological Chemistry, 2012, 10.1074/jbc.M112.393561
Apoptosis-like programmed cell death induces antisense ribosomal RNA (rRNA) fragmentation and rRNA degradation in Leishmania, Padmanabhan, P.K., Samant, M., Cloutier, S., Simard, M.J., Papadopoulou, B., Cell Death and Differentiation, 2012, 10.1038/cdd.2012.85
Developmental characterization of the microRNA-specific C. elegans argonautes alg-1 and alg-2, Vasquez-Rifo, A., Jannot, G., Armisen, J., Labouesse, M., Bukhari, S.I.A., Rondeau, E.L., Miska, E.A., Simard, M.J., PLoS ONE, 2012, 10.1371/journal.pone.0033750
Down regulation of miR-124 in both Werner syndrome DNA helicase mutant mice and mutant Caenorhabditis elegans wrn-1 reveals the importance of this microRNA in accelerated aging, Dallaire, A., Garand, C., Paquet, E.R., Mitchell, S.J., de Cabo, R.D., Simard, M.J., Lebel, M., Aging, 2012
Function, targets, and evolution of Caenorhabditis elegans piRNAs, Bagijn, M.P., Goldstein, L.D., Sapetschnig, A., Weick, E.-M., Bouasker, S., Lehrbach, N.J., Simard, M.J., Miska, E.A., Science, 2012, 10.1126/science.1220952
MIR-20a represses endothelial cell migration by targeting MKK3 and inhibiting p38 MAP kinase activation in response to VEGF, Pin, A.-L., Houle, F., Guillonneau, M., Paquet, E.R., Simard, M.J., Huot, J., Angiogenesis, 2012, 10.1007/s10456-012-9283-z
Novel Features of a PIWI-Like Protein Homolog in the Parasitic Protozoan Leishmania, Padmanabhan, P.K., Dumas, C., Samant, M., Rochette, A., Simard, M.J., Papadopoulou, B., PLoS ONE, 2012, 10.1371/journal.pone.0052612
Polypyrimidine tract binding protein (hnRNP I) is possibly a conserved modulator of miRNA-mediated gene regulation, Engels, B., Jannot, G., Remenyi, J., Simard, M.J., Hutvagner, G., PLoS ONE, 2012, 10.1371/journal.pone.0033144
RIP-chip-SRM - A new combinatorial large-scale approach identifies a set of translationally regulated bantam/miR-58 targets in C. elegans, Jovanovic, M., Reiter, L., Clark, A., Weiss, M., Picotti, P., Rehrauer, H., Frei, A., Neukomm, L.J., Kaufman, E., Wollscheid, B., Simard, M.J., Miska, E.A., Aebersold, R., Gerber, A.P., Hengartner, M.O., Genome Research, 2012, 10.1101/gr.133330.111
The microRNA pathway controls germ cell proliferation and differentiation in C. elegans, Bukhari, S.I.A., Vasquez-Rifo, A., Gagné, D., Paquet, E.R., Zetka, M., Robert, C., Masson, J.-Y., Simard, M.J., Cell Research, 2012, 10.1038/cr.2012.31
The slicing activity of miRNA-specific Argonautes is essential for the miRNA pathway in C. elegans, Bouasker, S., Simard, M.J., Nucleic Acids Research, 2012, 10.1093/nar/gks748
Argonaute pull-down and RISC analysis using 2'-O-methylated oligonucleotides affinity matrices., Jannot, G., Vasquez-Rifo, A., Simard, M.J., Methods in molecular biology (Clifton, N.J.), 2011
Role for miR-204 in human pulmonary arterial hypertension, Courboulin, A., Paulin, R., Giguère, N.J., Saksouk, N., Perreault, T., Meloche, J., Paquet, E.R., Biardel, S., Provencher, S., Côté, J., Simard, M.J., Bonnet, S., Journal of Experimental Medicine, 2011, 10.1084/jem.20101812
The ribosomal protein RACK1 is required for microRNA function in both C. elegans and humans, Jannot, G., Bajan, S., Giguère, N.J., Bouasker, S., Banville, I.H., Piquet, S., Hutvagner, G., Simard, M.J., EMBO Reports, 2011, 10.1038/embor.2011.66
A new twist in the microRNA pathway: Not dicer but argonaute is required for a microRNA production, Bossé, G.D., Simard, M.J., Cell Research, 2010, 10.1038/cr.2010.83
RNAi pathway in C. elegans: The argonautes and collaborators, Boisvert, M.-E.L., Simard, M.J., Current Topics in Microbiology and Immunology, 2008, 10.1007/978-3-540-75157-1_2
Two molecular features contribute to the Argonaute specificity for the microRNA and RNAi pathways in C. elegans, Jannot, G., Boisvert, M.-E.L., Banville, I.H., Simard, M.J., RNA, 2008, 10.1261/rna.901908
Analysis of the C. elegans Argonaute Family Reveals that Distinct Argonautes Act Sequentially during RNAi, Yigit, E., Batista, P.J., Bei, Y., Pang, K.M., Chen, C.-C.G., Tolia, N.H., Joshua-Tor, L., Mitani, S., Simard, M.J., Mello, C.C., Cell, 2006, 10.1016/j.cell.2006.09.033
Human let-7a miRNA blocks protein production on actively translating polyribosomes, Nottrott, S., Simard, M.J., Richter, J.D., Nature Structural and Molecular Biology, 2006, 10.1038/nsmb1173
A member of the polymerase β nucleotidyltransferase superfamily is required for RNA interference in C. elegans, Chen, C.-C.G., Simard, M.J., Tabara, H., Brownell, D.R., McCollough, J.A., Mello, C.C., Current Biology, 2005, 10.1016/j.cub.2005.01.009
Sequence-specific inhibition of small RNA function, Hutvágner, G., Simard, M.J., Mello, C.C., Zamore, P.D., PLoS Biology, 2004, 10.1371/journal.pbio.0020098
Heterogeneous nuclear ribonucleoprotein particle A/B proteins and the control of alternative splicing of the mammalian heterogeneous nuclear ribonucleoprotein particle A1 pre-mRNA., Chabot, B., LeBel, C., Hutchison, S., Nasim, F.H., Simard, M.J., Progress in molecular and subcellular biology, 2003
SRp30c is a repressor of 3′ splice site utilization, Simard, M.J., Chabot, B., Molecular and Cellular Biology, 2002, 10.1128/MCB.22.12.4001-4010.2002
A novel mutation in the neurofibromatosis type 1 (NF1) gene promotes skipping of two exons by preventing exon definition, Fang, L.J., Simard, M.J., Vidaud, D., Assouline, B., Lemieux, B., Vidaud, M., Chabot, B., Thirion, J.-P., Journal of Molecular Biology, 2001, 10.1006/jmbi.2001.4561
Control of hnRNP A1 alternative splicing: An intron element represses use of the common 3' splice site, Simard, M.J., Chabot, B., Molecular and Cellular Biology, 2000, 10.1128/MCB.20.19.7353-7362.2000
An element in the 5' common exon of the NCAM alternative splicing unit interacts with SR proteins and modulates 5' splice site selection, Côté, J., Simard, M.J., Chabot, B., Nucleic Acids Research, 1999, 10.1093/nar/27.12.2529
Kinetics of eosinophilia and eosinophil activation in the development of non-allergic bronchial hyperresponsiveness in guinea pigs injected with Sephadex beads, Maghni, K., Simard, M.J., Arseneault, D., Sirois, P., Inflammation, 1996, 10.1007/BF01487044
Relationship between the development of bronchial hyperresponsiveness and the airway eosinophilia in guinea pigs following injection with Sephadex beads, Maghni, K., Simard, M.J., Cloutier, S., Arseneault, D., Sirois, P., Inflammation Research, 1995, 10.1007/BF01778318
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Contribution à l'enseignement aux cycles supérieurs
Étudiant(e)s dirigé(e)s*
Depuis 2009
Vincent Roy - Maitrîse avec mémoire - En cours
Pierre-Marc Frédérick - Doctorat - En cours
Michael Lantin - Maitrîse avec mémoire - En cours
Anisha Pal - Doctorat - En cours
Vivek Shah - Doctorat - En cours
Mickael Lhuillier - Doctorat - En cours
Pavan Kumar Kakumani - Post-doctorat - En cours
Louis-Mathieu Harvey - Doctorat - En cours
Johannie Ducharme - Maitrîse avec mémoire - 2011/05
Gabriel Bossé - Doctorat - 2014/09
Alexandra Dallaire - Maitrîse avec mémoire - 2016/01
Liang Zhong - Doctorat - 2018/05
Catherine Roy Bellavance - Doctorat - 2018/05
Pascale Michaud - Maitrîse avec mémoire - 2018/09
Encadrement d'étudiant(e)s pour les programmes suivants :
*Les supervisions d’étudiant(e)s de 1er cycle en
stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées
ultérieurement.
Vice-décanat à la recherche et aux études supérieures Pavillon Ferdinand-Vandry Université Laval 1050, avenue de la Médecine, local 4645 Québec, Québec G1V 0A6 Canada
Catherine Comtois Agente de gestion des études etudes.sup2@fmed.ulaval.ca Biostatistique Épidémiologie Évaluation économique des technologies de la santé Santé publique
Marianne Rivest et Claudia Gonzalez Agentes de gestion des études etudes.sup1@fmed.ulaval.ca Biologie cellulaire et moléculaire Génomique fonctionnelle Médecine moléculaire Microbiologie-immunologie Neurosciences
Isabelle Tremblay Agente de gestion des études etudes.sup3@fmed.ulaval.ca Pédagogie universitaire en sciences de la santé Sciences cliniques et biomédicales Sciences de la réadaptation Prévention et gestion de la santé et de la sécurité au travail