Martin Simard
Professeur titulaire
Centre de recherche sur le cancer
Centre de recherche du CHU de Québec - Université Laval
Contribution à la recherche
Axe de recherche de l'Université Laval :
Santé et bien-être durables
Thématiques de recherche de la Faculté de médecine :
Oncologie
Domaines et intérêts de recherche du (de la) professeur(e) :
Cancer
- Génétique du cancer
- Signalisation cellulaire et cancer
- Diagnostic et détection du cancer
Projets de recherche
- Understanding the regulation and implication of Argonaute in microRNA-mediated gene silencing. - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2020-10-01 au 2025-09-30
- Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
- Genetic and molecular analysis of the siRNA-mediated gene regulation - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC), Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2019-04-01 au 2024-03-31
- Canadian Developmental Biology Conference 2023 - Instituts de recherche en santé du Canada - Programme d'’appui communautaire des instituts (PACI), co-chercheur - 2021-04-01 au 2023-03-31
- Acquisition d'un appareil PCR pour analyses d'échantillons biologiques - Fondation du CHU de Québec, chercheur principal - 2021-07-16 au 2022-07-15
- Étude de la régulation des gènes par les courts ARNs non-codants - Fonds de recherche du Québec - Santé - Chaires de recherche FRQS, chercheur principal - 2017-07-01 au 2021-06-30
- Soutien salarial d'un professeur - CHU de Québec – Université Laval – Hôpital Hôtel-Dieu-de-Québec, CHUQ - Hôpital Hôtel-Dieu de Québec --- utiliser sirul no. 7695, chercheur principal - 2006-07-01 au 2021-06-30
- Functional dissection of the microRNA pathway. - Instituts de recherche en santé du Canada - Subvention de fonctionnement, chercheur principal - 2015-07-01 au 2021-03-31
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Publications
- Regulation and different functions of the animal microRNA‐induced silencing complex, Pierre‐Marc Frédérick, Martin J. Simard, WIREs RNA, 2021, 10.1002/wrna.1701
- CSDE1 attenuates microRNA-mediated silencing of PMEPA1 in melanoma, Pavan Kumar Kakumani, Tanit Guitart, Francois Houle, Louis-Mathieu Harvey, Benjamin Goyer, Lucie Germain, Fátima Gebauer, Martin J. Simard, Oncogene, 2021, 10.1038/s41388-021-01767-9
- The RabGAP TBC-11 controls Argonaute localization for proper microRNA function in C. elegans, Pascale Michaud, Vivek Nilesh Shah, Pauline Adjibade, Francois Houle, Miguel Quévillon Huberdeau, Rachel Rioux, Camille Lavoie-Ouellet, Weifeng Gu, Rachid Mazroui, Martin J. Simard, PLOS Genetics, 2021, 10.1371/journal.pgen.1009511
- CSDE1 controls gene expression through the miRNA-mediated decay machinery, Pavan Kumar Kakumani, Louis-Mathieu Harvey, François Houle, Tanit Guitart, Fátima Gebauer, Martin J Simard, Life Science Alliance, 2020, 10.26508/lsa.201900632
- A guide to micro RNA ‐mediated gene silencing, Miguel Quévillon Huberdeau, Martin J. Simard, The FEBS Journal, 2019, 10.1111/febs.14666
- p38 activation induces production of miR-146a and miR-31 to repress E-selectin expression and inhibit transendothelial migration of colon cancer cells, Liang Zhong, Jacques Huot, Martin J. Simard, Scientific Reports, 2018, 10.1038/s41598-018-20837-9
- Somatic and Germline MicroRNAs Form Distinct Silencing Complexes to Regulate Their Target mRNAs Differently, Alexandra Dallaire, Pierre-Marc Frédérick, Martin J. Simard, Developmental Cell, 2018, 10.1016/j.devcel.2018.08.022
- Biogenesis of small non-coding RNAs in animals | La biogenèse des ARN courts non codants chez les animaux, Fressigné, L., Simard, M.J., Medecine/Sciences, 2018, 10.1051/medsci/20183402011
- P38 and JNK pathways control E-selectin-dependent extravasation of colon cancer cells by modulating miR-31 transcription, Zhong, L., Simoneau, B., Huot, J., Simard, M.J., Oncotarget, 2017, 10.18632/oncotarget.13779
- Phosphorylation of Argonaute proteins affects mRNA binding and is essential for microRNA-guided gene silencing in vivo, Quévillon Huberdeau, M., Zeitler, D.M., Hauptmann, J., Bruckmann, A., Fressigné, L., Danner, J., Piquet, S., Strieder, N., Engelmann, J.C., Jannot, G., Deutzmann, R., Simard, M.J., Meister, G., EMBO Journal, 2017, 10.15252/embj.201696386
- TEG-1 CD2BP2 controls miRNA levels by regulating miRISC stability in C. elegans and human cells, Wang, C., Gupta, P., Fressigne, L., Bossé, G.D., Wang, X., Simard, M.J., Hansen, D., Nucleic acids research, 2017, 10.1093/nar/gkw836
- The R148.3 gene modulates Caenorhabditis elegans lifespan and fat metabolism, Roy-Bellavance, C., Grants, J.M., Miard, S., Lee, K., Rondeau, É., Guillemette, C., Simard, M.J., Taubert, S., Picard, F., G3: Genes, Genomes, Genetics, 2017, 10.1534/g3.117.041681
- GW182-Free microRNA Silencing Complex Controls Post-transcriptional Gene Expression during Caenorhabditis elegans Embryogenesis, Jannot, G., Michaud, P., Quévillon Huberdeau, M., Morel-Berryman, L., Brackbill, J.A., Piquet, S., McJunkin, K., Nakanishi, K., Simard, M.J., PLoS Genetics, 2016, 10.1371/journal.pgen.1006484
- Poly(A)-binding proteins are required for microRNA-mediated silencing and to promote target deadenylation in C. elegans, Flamand, M.N., Wu, E., Vashisht, A., Jannot, G., Keiper, B.D., Simard, M.J., Wohlschlegel, J., Duchaine, T.F., Nucleic Acids Research, 2016, 10.1093/nar/gkw276
- The implication of microRNAs and endo-siRNAs in animal germline and early development, Dallaire, A., Simard, M.J., Developmental Biology, 2016, 10.1016/j.ydbio.2016.06.007
- MicroRNA-19a enhances proliferation of bronchial epithelial cells by targeting TGFβR2 gene in severe asthma, Haj-Salem, I., Fakhfakh, R., Bérubé, J.-C., Jacques, E., Plante, S., Simard, M.J., Bossé, Y., Chakir, J., Allergy: European Journal of Allergy and Clinical Immunology, 2015, 10.1111/all.12551
- The human decapping scavenger enzyme DcpS modulates microRNA turnover, Meziane, O., Piquet, S., Bossé, G.D., Gagné, D., Paquet, E., Robert, C., Tones, M.A., Simard, M.J., Scientific Reports, 2015, 10.1038/srep16688
- Expression profile of Caenorhabditis elegans mutant for the Werner syndrome gene ortholog reveals the impact of vitamin C on development to increase life span, Dallaire, A., Proulx, S., Simard, M.J., Lebel, M., BMC Genomics, 2014, 10.1186/1471-2164-15-940
- Mutations in Conserved Residues of the C. elegans microRNA Argonaute ALG-1 Identify Separable Functions in ALG-1 miRISC Loading and Target Repression, Zinovyeva, A.Y., Bouasker, S., Simard, M.J., Hammell, C.M., Ambros, V., PLoS Genetics, 2014, 10.1371/journal.pgen.1004286
- A New Role for the GARP Complex in MicroRNA-Mediated Gene Regulation, Vasquez-Rifo, A., Bossé, G.D., Rondeau, E.L., Jannot, G., Dallaire, A., Simard, M.J., PLoS Genetics, 2013, 10.1371/journal.pgen.1003961
- Next-generation biobanking of metastases to enable multidimensional molecular profiling in personalized medicine, Diaz, Z., Aguilar-Mahecha, A., Paquet, E.R., Basik, M., Orain, M., Camlioglu, E., Constantin, A., Benlimame, N., Bachvarov, D., Jannot, G., Simard, M.J., Chabot, B., Gologan, A., Klinck, R., Gagnon-Kugler, T., Lespérance, B., Samson, B., Kavan, P., Alcindor, T., Dalfen, R., Lan, C., Chabot, C., Buchanan, M., Przybytkowrski, E., Qureshi, S., Rousseau, C., Spatz, A., Têtu, B., Batist, G., Modern Pathology, 2013, 10.1038/modpathol.2013.81
- The Decapping Scavenger Enzyme DCS-1 Controls MicroRNA Levels in Caenorhabditis elegans, Bossé, G.D., Rüegger, S., Ow, M.C., Vasquez-Rifo, A., Rondeau, E.L., Ambros, V.R., Großhans, H., Simard, M.J., Molecular Cell, 2013, 10.1016/j.molcel.2013.02.023
- The decapping scavenger enzyme DCS-1: A new modulator of miRNA turnover, Meziane, O., Bossé, G.D., Simard, M.J., Cell Cycle, 2013, 10.4161/cc.26076
- Annexin-1-mediated endothelial cell migration and angiogenesis are regulated by vascular endothelial growth factor (VEGF)-induced inhibition of miR-196a expression, Pin, A.-L., Houle, F., Fournier, P., Guillonneau, M., Paquet, É.R., Simard, M.J., Royal, I., Huot, J., Journal of Biological Chemistry, 2012, 10.1074/jbc.M112.393561
- Apoptosis-like programmed cell death induces antisense ribosomal RNA (rRNA) fragmentation and rRNA degradation in Leishmania, Padmanabhan, P.K., Samant, M., Cloutier, S., Simard, M.J., Papadopoulou, B., Cell Death and Differentiation, 2012, 10.1038/cdd.2012.85
- Developmental characterization of the microRNA-specific C. elegans argonautes alg-1 and alg-2, Vasquez-Rifo, A., Jannot, G., Armisen, J., Labouesse, M., Bukhari, S.I.A., Rondeau, E.L., Miska, E.A., Simard, M.J., PLoS ONE, 2012, 10.1371/journal.pone.0033750
- Down regulation of miR-124 in both Werner syndrome DNA helicase mutant mice and mutant Caenorhabditis elegans wrn-1 reveals the importance of this microRNA in accelerated aging, Dallaire, A., Garand, C., Paquet, E.R., Mitchell, S.J., de Cabo, R.D., Simard, M.J., Lebel, M., Aging, 2012
- Function, targets, and evolution of Caenorhabditis elegans piRNAs, Bagijn, M.P., Goldstein, L.D., Sapetschnig, A., Weick, E.-M., Bouasker, S., Lehrbach, N.J., Simard, M.J., Miska, E.A., Science, 2012, 10.1126/science.1220952
- MIR-20a represses endothelial cell migration by targeting MKK3 and inhibiting p38 MAP kinase activation in response to VEGF, Pin, A.-L., Houle, F., Guillonneau, M., Paquet, E.R., Simard, M.J., Huot, J., Angiogenesis, 2012, 10.1007/s10456-012-9283-z
- Novel Features of a PIWI-Like Protein Homolog in the Parasitic Protozoan Leishmania, Padmanabhan, P.K., Dumas, C., Samant, M., Rochette, A., Simard, M.J., Papadopoulou, B., PLoS ONE, 2012, 10.1371/journal.pone.0052612
- Polypyrimidine tract binding protein (hnRNP I) is possibly a conserved modulator of miRNA-mediated gene regulation, Engels, B., Jannot, G., Remenyi, J., Simard, M.J., Hutvagner, G., PLoS ONE, 2012, 10.1371/journal.pone.0033144
- RIP-chip-SRM - A new combinatorial large-scale approach identifies a set of translationally regulated bantam/miR-58 targets in C. elegans, Jovanovic, M., Reiter, L., Clark, A., Weiss, M., Picotti, P., Rehrauer, H., Frei, A., Neukomm, L.J., Kaufman, E., Wollscheid, B., Simard, M.J., Miska, E.A., Aebersold, R., Gerber, A.P., Hengartner, M.O., Genome Research, 2012, 10.1101/gr.133330.111
- The microRNA pathway controls germ cell proliferation and differentiation in C. elegans, Bukhari, S.I.A., Vasquez-Rifo, A., Gagné, D., Paquet, E.R., Zetka, M., Robert, C., Masson, J.-Y., Simard, M.J., Cell Research, 2012, 10.1038/cr.2012.31
- The slicing activity of miRNA-specific Argonautes is essential for the miRNA pathway in C. elegans, Bouasker, S., Simard, M.J., Nucleic Acids Research, 2012, 10.1093/nar/gks748
- Argonaute pull-down and RISC analysis using 2'-O-methylated oligonucleotides affinity matrices., Jannot, G., Vasquez-Rifo, A., Simard, M.J., Methods in molecular biology (Clifton, N.J.), 2011
- Role for miR-204 in human pulmonary arterial hypertension, Courboulin, A., Paulin, R., Giguère, N.J., Saksouk, N., Perreault, T., Meloche, J., Paquet, E.R., Biardel, S., Provencher, S., Côté, J., Simard, M.J., Bonnet, S., Journal of Experimental Medicine, 2011, 10.1084/jem.20101812
- The ribosomal protein RACK1 is required for microRNA function in both C. elegans and humans, Jannot, G., Bajan, S., Giguère, N.J., Bouasker, S., Banville, I.H., Piquet, S., Hutvagner, G., Simard, M.J., EMBO Reports, 2011, 10.1038/embor.2011.66
- A new twist in the microRNA pathway: Not dicer but argonaute is required for a microRNA production, Bossé, G.D., Simard, M.J., Cell Research, 2010, 10.1038/cr.2010.83
- Structural biology: Tracing Argonaute binding, Bouasker, S., Simard, M.J., Nature, 2009, 10.1038/461743a
- Argonaute proteins: Key players in RNA silencing, Hutvagner, G., Simard, M.J., Nature Reviews Molecular Cell Biology, 2008, 10.1038/nrm2321
- RNAi pathway in C. elegans: The argonautes and collaborators, Boisvert, M.-E.L., Simard, M.J., Current Topics in Microbiology and Immunology, 2008, 10.1007/978-3-540-75157-1_2
- Two molecular features contribute to the Argonaute specificity for the microRNA and RNAi pathways in C. elegans, Jannot, G., Boisvert, M.-E.L., Banville, I.H., Simard, M.J., RNA, 2008, 10.1261/rna.901908
- Analysis of the C. elegans Argonaute Family Reveals that Distinct Argonautes Act Sequentially during RNAi, Yigit, E., Batista, P.J., Bei, Y., Pang, K.M., Chen, C.-C.G., Tolia, N.H., Joshua-Tor, L., Mitani, S., Simard, M.J., Mello, C.C., Cell, 2006, 10.1016/j.cell.2006.09.033
- Human let-7a miRNA blocks protein production on actively translating polyribosomes, Nottrott, S., Simard, M.J., Richter, J.D., Nature Structural and Molecular Biology, 2006, 10.1038/nsmb1173
- Tumour-related microRNAs functions in Caenorhabditis elegans, Jannot, G., Simard, M.J., Oncogene, 2006, 10.1038/sj.onc.1209921
- A member of the polymerase β nucleotidyltransferase superfamily is required for RNA interference in C. elegans, Chen, C.-C.G., Simard, M.J., Tabara, H., Brownell, D.R., McCollough, J.A., Mello, C.C., Current Biology, 2005, 10.1016/j.cub.2005.01.009
- Sequence-specific inhibition of small RNA function, Hutvágner, G., Simard, M.J., Mello, C.C., Zamore, P.D., PLoS Biology, 2004, 10.1371/journal.pbio.0020098
- Heterogeneous nuclear ribonucleoprotein particle A/B proteins and the control of alternative splicing of the mammalian heterogeneous nuclear ribonucleoprotein particle A1 pre-mRNA., Chabot, B., LeBel, C., Hutchison, S., Nasim, F.H., Simard, M.J., Progress in molecular and subcellular biology, 2003
- SRp30c is a repressor of 3′ splice site utilization, Simard, M.J., Chabot, B., Molecular and Cellular Biology, 2002, 10.1128/MCB.22.12.4001-4010.2002
- A novel mutation in the neurofibromatosis type 1 (NF1) gene promotes skipping of two exons by preventing exon definition, Fang, L.J., Simard, M.J., Vidaud, D., Assouline, B., Lemieux, B., Vidaud, M., Chabot, B., Thirion, J.-P., Journal of Molecular Biology, 2001, 10.1006/jmbi.2001.4561
- Control of hnRNP A1 alternative splicing: An intron element represses use of the common 3' splice site, Simard, M.J., Chabot, B., Molecular and Cellular Biology, 2000, 10.1128/MCB.20.19.7353-7362.2000
- An element in the 5' common exon of the NCAM alternative splicing unit interacts with SR proteins and modulates 5' splice site selection, Côté, J., Simard, M.J., Chabot, B., Nucleic Acids Research, 1999, 10.1093/nar/27.12.2529
- Kinetics of eosinophilia and eosinophil activation in the development of non-allergic bronchial hyperresponsiveness in guinea pigs injected with Sephadex beads, Maghni, K., Simard, M.J., Arseneault, D., Sirois, P., Inflammation, 1996, 10.1007/BF01487044
- Relationship between the development of bronchial hyperresponsiveness and the airway eosinophilia in guinea pigs following injection with Sephadex beads, Maghni, K., Simard, M.J., Cloutier, S., Arseneault, D., Sirois, P., Inflammation Research, 1995, 10.1007/BF01778318
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Contribution à l'enseignement aux cycles supérieurs
Étudiant(e)s dirigé(e)s*
Depuis 2009- Vincent Roy - Maitrîse avec mémoire - En cours
- Pierre-Marc Frédérick - Doctorat - En cours
- Michael Lantin - Maitrîse avec mémoire - En cours
- Anisha Pal - Doctorat - En cours
- Vivek Shah - Doctorat - En cours
- Mickael Lhuillier - Doctorat - En cours
- Pavan Kumar Kakumani - Post-doctorat - En cours
- Louis-Mathieu Harvey - Doctorat - En cours
- Johannie Ducharme - Maitrîse avec mémoire - 2011/05
- Gabriel Bossé - Doctorat - 2014/09
- Alexandra Dallaire - Maitrîse avec mémoire - 2016/01
- Liang Zhong - Doctorat - 2018/05
- Catherine Roy Bellavance - Doctorat - 2018/05
- Pascale Michaud - Maitrîse avec mémoire - 2018/09
Encadrement d'étudiant(e)s pour les programmes suivants :
Disponibilité d'encadrement d'étudiant(e)s
Ce (cette) professeur(e) est présentement à la recherche d'étudiant(e)s.
Envoyer un courriel*Les supervisions d’étudiant(e)s de 1er cycle en
stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées
ultérieurement.