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Centre de recherche du CHU de Québec - Université Laval
Centre de recherche en arthrite (ARThrite)
Partager la fiche :
Contribution à la recherche
Axe de recherche de l'Université Laval :
Santé et bien-être durables
Thématiques de recherche de la Faculté de
médecine :
Immunologie-infectiologie
Santé cardiovasculaire, respiratoire et métabolisme
Domaines et intérêts de recherche du (de la)
professeur(e) :
Appareil locomoteur et arthrite
Arthrite/arthrose
Maladies infectieuses et immunitaires
Maladies auto-immunes
Maladies du système immunitaire
Médiateurs immunologiques : cytokines et chimiokines
Système immunitaire
Nutrition et métabolisme
Maladie de Crohn
Métabolisme
Métabolisme énergétique
Toxicologie
Projets de recherche
Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval- Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
La nanoparticule PapMV-fMLF, une nouvelle classe d'immunostimulant pour prévenir les infections respiratoires virales - Fondation du CHU de Québec, Ministère de l'Économie et de l'Innovation - Programme de soutien aux organismes de recherche et d’innovation (PSO) - Volet 2 : Soutien aux projets, co-chercheur - 2021-12-17 au 2022-12-16
Surveillance des réponses immunitaires au vaccin contre la COVID-19 chez les personnes vivant avec le VIH-1- Instituts de recherche en santé du Canada - Subvention de fonctionnement:Nouveaux besoins prioritaires en recherche sur la COVID-19, co-chercheur - 2021-12-01 au 2022-11-30
Salaire d'un professeur- CHU de Québec – Université Laval – CHUL, chercheur principal - 2014-08-01 au 2022-06-30
Métabolisme bioénergétique et réponse fonctionnelle des cellules inflammatoires : Étude de facteurs endogènes et environnementaux- Fonds de recherche du Québec - Santé - Chercheur-boursier Juniors 1 et 2, Seniors, chercheur principal - 2018-07-01 au 2022-06-30
Defining the Effects of Endocrine-Disrupting chemicals on the cellular metabolism of inflammatory cells.- Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2015-04-01 au 2022-03-31
Développement d’une méthode fiable pour la détection d’anticorps contre Malassezia- Fondation de l'Université Laval, chercheur principal - 2020-04-01 au 2022-03-31
Bourse Concert pour la vie - Fondation du CHU de Québec, chercheur principal - 2020-11-13 au 2021-11-12
Étude de la réponse immune contre Malassezia dans la maladie de Crohn- Fondation de l'Université Laval, chercheur principal - 2018-11-01 au 2021-10-31
Réponse immunitaire contre le champignon Malassezia dans la prostate- Fondation de l'Université Laval, chercheur principal - 2019-11-01 au 2021-10-31
CUASF-BCC Research Grant Program - Association canadienne d'urologie, co-chercheur - 2020-06-06 au 2021-06-05
Repositionnement du fumarate de diméthyle pour traiter la COVID-19: une molécule à double action au potentiel antiviral et anti-inflammatoire- Fonds de recherche du Québec - Santé - Réseaux thématiques de recherche, Université de Montréal, co-chercheur - 2020-05-11 au 2021-04-30
Profil moléculaire sanguin de patientes souffrant de lupus- CHU de Québec – Université Laval – CHUL - Développement de la recherche (RFI), co-chercheur - 2019-04-01 au 2021-03-31
Évaluation du profil de cytokines par les leucocytes sanguins : étude d'un cas clinique- Fondation du CHU de Québec, chercheur principal - 2020-04-07 au 2021-03-31
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Publications
Impacts of endocrine-disrupting chemicals on prostate function and cancer, Aurélie Lacouture, Camille Lafront, Cindy Peillex, Martin Pelletier, Étienne Audet-Walsh, Environmental Research, 2022, 10.1016/j.envres.2021.112085
Expression of the myeloid inhibitory receptor CLEC12A correlates with disease activity and cytokines in early rheumatoid arthritis, Myriam Vaillancourt, Philippe Desaulniers, Guillaume Paré, Nathalie Pagé, Asmaa Lachhab, Anthony Kerever, Anne-Sophie Julien, Nathalie Amiable, Martin Pelletier, Philippe A. Tessier, Louis Bessette, Laëtitia Michou, Paul R. Fortin, Maria J. Fernandes, Scientific Reports, 2021, 10.1038/s41598-021-90631-7
Heat-Inactivation of Fetal and Newborn Sera Did Not Impair the Expansion and Scaffold Engineering Potentials of Fibroblasts, Félix-Antoine Pellerin, Christophe Caneparo, Ève Pellerin, Stéphane Chabaud, Martin Pelletier, Stéphane Bolduc, Bioengineering, 2021, 10.3390/bioengineering8110184
Bisphenol A Alters the Energy Metabolism of Stromal Cells and Could Promote Bladder Cancer Progression, Ève Pellerin, Stéphane Chabaud, Frédéric Pouliot, Martin Pelletier, Stéphane Bolduc, Cancers, 2021, 10.3390/cancers13215461
Bisphenol A, bisphenol S and their glucuronidated metabolites modulate glycolysis and functional responses of human neutrophils, Cindy Peillex, Anthony Kerever, Asmaa Lachhab, Martin Pelletier, Environmental Research, 2021, 10.1016/j.envres.2020.110336
Colchicine for community-treated patients with COVID-19 (COLCORONA): a phase 3, randomised, double-blinded, adaptive, placebo-controlled, multicentre trial, , The Lancet Respiratory Medicine, 2021, 10.1016/s2213-2600(21)00222-8
Endocrine-disrupting effects of bisphenols on urological cancers, Eve Pellerin, Christophe Caneparo, Stéphane Chabaud, Stéphane Bolduc, Martin Pelletier, Environmental Research, 2021, 10.1016/j.envres.2020.110485
The evaluation of cytokines to help establish diagnosis and guide treatment of autoinflammatory and autoimmune diseases, Anne‐Laure Chetaille Nézondet, Patrice E. Poubelle, Martin Pelletier, Journal of Leukocyte Biology, 2020, 10.1002/JLB.5MR0120-218RRR
The impact and toxicity of glyphosate and glyphosate-based herbicides on health and immunity, Cindy Peillex, Martin Pelletier, Journal of Immunotoxicology, 2020, 10.1080/1547691X.2020.1804492
The use of leukocytes’ secretome to individually target biological therapy in autoimmune arthritis: a case report, Patrice E. Poubelle, Nathalie Pagé, Marie‐Pier Longchamps, Natalia Sampaio Moura, David B. Beck, Ivona Aksentijevich, Philippe A. Tessier, Martin Pelletier, Clinical and Translational Medicine, 2019, 10.1186/s40169-019-0236-7
Anti-mitochondrial autoantibodies in systemic lupus erythematosus and their association with disease manifestations, Becker, Y., Loignon, R.-C., Julien, A.-S., Marcoux, G., Allaeys, I., Lévesque, T., Rollet-Labelle, E., Benk-Fortin, H., Cloutier, N., Melki, I., Eder, L., Wagner, É., Pelletier, M., Hajj, H.E., Tremblay, M.-È., Belleannée, C., Hébert, M.-J., Dieudé, M., Rauch, J., Fortin, P.R., Boilard, E., Scientific Reports, 2019, 10.1038/s41598-019-40900-3
Tumor-associated macrophages enhance tumor hypoxia and aerobic glycolysis, Jeong, H., Kim, S., Hong, B.-J., Lee, C.-J., Kim, Y.-E., Bok, S., Oh, J.-M., Gwak, S.-H., Yoo, M.Y., Lee, M.S., Chung, S.-J., Defrêne, J., Tessier, P., Pelletier, M., Jeon, H., Roh, T.-Y., Kim, B., Kim, K.H., Ju, J.H., Kim, S., Lee, Y.-J., Kim, D.-W., Kim, I.H., Kim, H.J., Park, J.-W., Lee, Y.-S., Lee, J.S., Cheon, G.J., Weissman, I.L., Chung, D.H., Jeon, Y.K., Ahn, G.-O., Cancer Research, 2019, 10.1158/0008-5472.CAN-18-2545
Quinoline-3-carboxamides such as tasquinimod are not specific inhibitors of S100A9, Martin Pelletier, Jean-Christophe Simard, Denis Girard, Philippe A. Tessier, Blood Advances, 2018, 10.1182/bloodadvances.2018016667
S100A9 induces differentiation of acute myeloid leukemia cells through TLR4, Malika Laouedj, Mélanie R. Tardif, Laurine Gil, Marie-Astrid Raquil, Asmaa Lachhab, Martin Pelletier, Philippe A. Tessier, Frédéric Barabé, Blood, 2017, 10.1182/blood-2016-09-738005
S100A9 potentiates the activation of neutrophils by the etiological agent of gout, monosodium urate crystals, Rousseau, L.-S., Paré, G., Lachhab, A., Naccache, P.H., Marceau, F., Tessier, P., Pelletier, M., Fernandes, M., Journal of Leukocyte Biology, 2017, 10.1189/jlb.3MA0117-020R
Critical role of fatty acid metabolism in ILC2-mediated barrier protection during malnutrition and helminth infection, Christoph Wilhelm, Oliver J. Harrison, Vanessa Schmitt, Martin Pelletier, Sean P. Spencer, Joseph F. Urban, Jr., Michelle Ploch, Thirumalai R. Ramalingam, Richard M. Siegel, Yasmine Belkaid, Journal of Experimental Medicine, 2016, 10.1084/jem.20151448
Erratum: Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type i IFN production (Journal of Clinical Investigation (2015) 125:11 (4196-4211) DOI: 10.1172/JCI81260), Brehm, A., Liu, Y., Sheikh, A., Marrero, B., Omoyinmi, E., Zhou, Q., Montealegre, G., Biancotto, A., Reinhardt, A., De Jesus, A.A., Pelletier, M., Tsai, W.L., Remmers, E.F., Kardava, L., Hill, S., Kim, H., Lachmann, H.J., Megarbane, A., Chae, J.J., Brady, J., Castillo, R.D., Brown, D., Casano, A.V., Gao, L., Chapelle, D., Huang, Y., Stone, D., Chen, Y., Sotzny, F., Lee, C.-C.R., Kastner, D.L., Torrelo, A., Zlotogorski, A., Moir, S., Gadina, M., McCoy, P., Wesley, R., Rother, K.I., Hildebrand, P.W., Brogan, P., Krüger, E., Aksentijevich, I., Goldbach-Mansky, R., Journal of Clinical Investigation, 2016, 10.1172/JCI86020
Le profil de sécrétion de cytokines par les leucocytes sanguins aide au diagnostic et au traitement des patients atteints de maladies auto-inflammatoires, Nézondet-Chetaille, A.L., Longchamps, M.P., Pagé, N., Leclerc, M., Tessier, P., Pelletier, M., Revue du Rhumatisme (Edition Francaise), 2016, 10.1016/S1169-8330(16)30609-3
Recruitment of A20 by the C-terminal domain of NEMO suppresses NF-κB activation and autoinflammatory disease, Zilberman-Rudenko, J., Shawver, L.M., Wessel, A.W., Luo, Y., Pelletier, M., Tsai, W.L., Lee, Y., Vonortas, S., Cheng, L., Ashwell, J.D., Orange, J.S., Siegel, R.M., Hanson, E.P., Proceedings of the National Academy of Sciences of the United States of America, 2016, 10.1073/pnas.1518163113
Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type i IFN production, Brehm, A., Liu, Y., Sheikh, A., Marrero, B., Omoyinmi, E., Zhou, Q., Montealegre, G., Biancotto, A., Reinhardt, A., De Jesus, A.A., Pelletier, M., Tsai, W.L., Remmers, E.F., Kardava, L., Hill, S., Kim, H., Lachmann, H.J., Megarbane, A., Chae, J.J., Brady, J., Castillo, R.D., Brown, D., Casano, A.V., Gao, L., Chapelle, D., Huang, Y., Stone, D., Chen, Y., Sotzny, F., Lee, C.-C.R., Kastner, D.L., Torrelo, A., Zlotogorski, A., Moir, S., Gadina, M., McCoy, P., Wesley, R., Rother, K., Hildebrand, P.W., Brogan, P., Krüger, E., Aksentijevich, I., Goldbach-Mansky, R., Journal of Clinical Investigation, 2015, 10.1172/JCI81260
Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects, Traba, J., Kwarteng-Siaw, M., Okoli, T.C., Li, J., Huffstutler, R.D., Bray, A., Waclawiw, M.A., Han, K., Pelletier, M., Sauve, A.A., Siegel, R.M., Sack, M.N., Journal of Clinical Investigation, 2015, 10.1172/JCI83260
The TNF-family ligand TL1A and its receptor DR3 promote T cell-mediated allergic immunopathology by enhancing differentiation and pathogenicity of IL-9-producing T cells, Richard, A.C., Tan, C., Hawley, E.T., Gomez-Rodriguez, J., Goswami, R., Yang, X.-P., Cruz, A.C., Penumetcha, P., Hayes, E.T., Pelletier, M., Gabay, O., Walsh, M., Ferdinand, J.R., Keane-Myers, A., Choi, Y., O'Shea, J.J., Al-Shamkhani, A., Kaplan, M.H., Gery, I., Siegel, R.M., Meylan, F., Journal of Immunology, 2015, 10.4049/jimmunol.1401220
Extracellular flux analysis to monitor glycolytic rates and mitochondrial oxygen consumption, Pelletier, M., Billingham, L.K., Ramaswamy, M., Siegel, R.M., Methods in Enzymology, 2014, 10.1016/B978-0-12-416618-9.00007-8
New tricks from an old dog: Mitochondrial redox signaling in cellular inflammation, Pelletier, M., Lepow, T.S., Billingham, L.K., Murphy, M.P., Siegel, R.M., Seminars in Immunology, 2012, 10.1016/j.smim.2013.01.002
Human neutrophils interact with both 6-sulfo LacNAc+ DC and NK cells to amplify NK-derived IFNγ: Role of CD18, ICAM-1, and ICAM-3, Costantini, C., Calzetti, F., Perbellini, O., Micheletti, A., Scarponi, C., Lonardi, S., Pelletier, M., Schakel, K., Pizzolo, G., Facchetti, F., Vermi, W., Albanesi, C., Cassatella, M.A., Blood, 2011, 10.1182/blood-2010-06-287243
Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS), Bulua, A.C., Simon, A., Maddipati, R., Pelletier, M., Park, H., Kim, K.-Y., Sack, M.N., Kastner, D.L., Siegel, R.M., Journal of Experimental Medicine, 2011, 10.1084/jem.20102049
Toll-like receptor-3-activated human mesenchymal stromal cells significantly prolong the survival and function of neutrophils, Cassatella, M.A., Mosna, F., Micheletti, A., Lisi, V., Tamassia, N., Cont, C., Calzetti, F., Pelletier, M., Pizzolo, G., Krampera, M., Stem Cells, 2011, 10.1002/stem.651
Evidence for a cross-talk between human neutrophils and Th17 cells, Pelletier, M., Maggi, L., Micheletti, A., Lazzeri, E., Tamassia, N., Costantini, C., Cosmi, L., Lunardi, C., Annunziato, F., Romagnani, S., Cassatella, M.A., Blood, 2010, 10.1182/blood-2009-04-216085
Modulation of human neutrophil survival and antigen expression by activated CD4+ and CD8+ T cells, Pelletier, M., Micheletti, A., Cassatella, M.A., Journal of Leukocyte Biology, 2010, 10.1189/jlb.0310172
Wishing away inflammation? New links between serotonin and TNF signaling, Pelletier, M., Siegel, R.M., Molecular Interventions, 2009, 10.1124/mi.9.6.5
Angiopoietin chemotactic activities on neutrophils are regulated by PI-3K activation, Brkovic, A., Pelletier, M., Girard, D., Sirois, M.G., Journal of Leukocyte Biology, 2007, 10.1189/jlb.0906580
Biological functions of interleukin-21 and its role in inflammation, Pelletier, M., Girard, D., TheScientificWorldJournal, 2007, 10.1100/tsw.2007.275
Molecular mechanisms involved in interleukin-4-induced human neutrophils: Expression and regulation of suppressor of cytokine signaling, Ratthé, C., Pelletier, M., Chiasson, S., Girard, D., Journal of Leukocyte Biology, 2007, 10.1189/jlb.0306209
Differential effects of IL-15 and IL-21 in myeloid (CD11b+) and lymphoid (CD11b-) bone marrow cells, Pelletier, M., Girard, D., Journal of Immunology, 2006, 10.4049/jimmunol.177.1.100
Interleukin-15 increases neutrophil adhesion onto human respiratory epithelial A549 cells and attracts neutrophils in vivo, Pelletier, M., Girard, D., Clinical and Experimental Immunology, 2005, 10.1111/j.1365-2249.2005.02861.x
In vivo and in vitro roles of IL-21 in inflammation, Pelletier, M., Bouchard, A., Girard, D., Journal of Immunology, 2004, 10.4049/jimmunol.173.12.7521
Activation of human epithelial lung A549 cells by the pollutant sodium sulfite: Enhancement of neutrophil adhesion, Pelletier, M., Lavastre, V., Girard, D., Toxicological Sciences, 2002, 10.1093/toxsci/69.1.210
Activation of human neutrophils by the pollutant sodium sulfite: Effect on cytokine production, chemotaxis, and cell surface expression of cell adhesion molecules, Ratthé, C., Pelletier, M., Roberge, C.J., Girard, D., Clinical Immunology, 2002, 10.1006/clim.2002.5282
Dieldrin induces human neutrophil superoxide production via protein kinases C and tyrosine kinases, Pelletier, M., Girard, D., Human and Experimental Toxicology, 2002, 10.1191/0960327102ht272oa
Mechanisms involved in interleukin-15-induced suppression of human neutrophil apoptosis: Role of the anti-apoptotic Mcl-1 protein and several kinases including Janus kinase-2, p38 mitogen-activated protein kinase and extracellular signal-regulated kinases-1/2, Pelletier, M., Ratthé, C., Girard, D., FEBS Letters, 2002, 10.1016/S0014-5793(02)03668-2
Mechanisms involved in spontaneous and Viscum album agglutinin-I-induced human neutrophil apoptosis: Viscum album agglutinin-I accelerates the loss of antiapoptotic Mcl-1 expression and the degradation of cytoskeletal paxillin and vimentin proteins via caspases, Lavastre, V., Pelletier, M., Saller, R., Hostanska, K., Girard, D., Journal of Immunology, 2002, 10.4049/jimmunol.168.3.1419
Toxaphene, but not beryllium, induces human neutrophil chemotaxis and apoptosis via reactive oxygen species (ROS): Involvement of caspases and ROS in the degradation of cytoskeletal proteins, Lavastre, V., Roberge, C.J., Pelletier, M., Gauthier, M., Girard, D., Clinical Immunology, 2002, 10.1006/clim.2002.5226
Activation of human neutrophils by technical toxaphene, Gauthier, M., Roberge, C.J., Pelletier, M., Tessier, P.A., Girard, D., Clinical Immunology, 2001, 10.1006/clim.2000.4946
Activation of human neutrophils in vitro and dieldrin-induced neutrophilic inflammation in vivo, Pelletier, M., Roberge, C.J., Gauthier, M., Vandal, K., Tessier, P.A., Girard, D., Journal of Leukocyte Biology, 2001
Modulation of interleukin-15-induced human neutrophil responses by the plant lectin Viscum album agglutinin-I, Pelletier, M., Lavastre, V., Savoie, A., Ratthé, C., Saller, R., Hostanska, K., Girard, D., Clinical Immunology, 2001, 10.1006/clim.2001.5105
Activation of human neutrophils by the air pollutant sodium sulfite (NA2SO3): Comparison with immature promyelocytic HL-60 and DMSO-differentiated HL-60 cells reveals that NA2SO3 is a neutrophil but not a HL-60 cell agonist, Pelletier, M., Savoie, A., Girard, D., Clinical Immunology, 2000, 10.1006/clim.2000.4883
Activation of human neutrophils by the plant lectin Viscum album agglutinin-I: Modulation of de novo protein synthesis and evidence that caspases are involved in induction of apoptosis, Savoie, A., Lavastre, V., Pelletier, M., Hajto, T., Hostanska, K., Girard, D., Journal of Leukocyte Biology, 2000
Activation of superoxide production by promyelocytic HL-60 cells with sodium sulfite, Pelletier, M., Girard, D., Journal of Investigative Medicine, 1999
Human neutrophil gene expression could be modulated by chemicals of environmental concern, Pelletier, M., Savoie, A., Girard, D., Journal of Investigative Medicine, 1999
Sodium sulfite increases the production of interleukin-8 (IL-8) but not tumor necrosis factor-alpha (TNF-α) in human neutrophils, Savoie, A., Pelletier, M., Girard, D., Journal of Investigative Medicine, 1999
Functional responses of human neutrophils to sodium sulfite (Na2SO3) in vitro, Labbé, P., Pelletier, M., Omara, F.O., Girard, D., Human and Experimental Toxicology, 1998, 10.1177/096032719801701103
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Contribution à l'enseignement aux cycles supérieurs
Étudiant(e)s dirigé(e)s*
Depuis 2009
Asmaa Lachhab - Doctorat - En cours
Eve Pellerin - Maitrîse avec mémoire - En cours
Pier-Olivier Leblanc - Maitrîse avec mémoire - En cours
Emma Bourgeault - Maitrîse avec mémoire - En cours
Louis-Simon Rousseau - Maitrîse avec mémoire - 2017/09
Anthony Kerever - Maitrîse avec mémoire - 2018/09
Marie-Pier Longchamps - Maitrîse avec mémoire - 2019/01
Encadrement d'étudiant(e)s pour les programmes suivants :
*Les supervisions d’étudiant(e)s de 1er cycle en
stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées
ultérieurement.
Vice-décanat à la recherche et aux études supérieures Pavillon Ferdinand-Vandry Université Laval 1050, avenue de la Médecine, local 4645 Québec (Québec) G1V 0A6 Canada
Catherine Comtois Agente de gestion des études etudes.sup2@fmed.ulaval.ca Biostatistique Épidémiologie Évaluation économique des technologies de la santé Santé publique
Marianne Rivest et Claudia Gonzalez Agentes de gestion des études etudes.sup1@fmed.ulaval.ca Biologie cellulaire et moléculaire Génomique fonctionnelle Médecine moléculaire Microbiologie-immunologie Neurosciences
Isabelle Tremblay Agente de gestion des études etudes.sup3@fmed.ulaval.ca Pédagogie universitaire en sciences de la santé Sciences cliniques et biomédicales Sciences de la réadaptation Prévention et gestion de la santé et de la sécurité au travail