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Martin Pelletier

Professeur agrégé

Martin Pelletier
martin.pelletier.21@ulaval.ca
Centre de recherche du CHU de Québec - Université Laval
Centre de recherche en arthrite (ARThrite)
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Immunologie-infectiologie
Santé cardiovasculaire, respiratoire et métabolisme

Domaines et intérêts de recherche du (de la) professeur(e) :

Appareil locomoteur et arthrite
  • Arthrite/arthrose
Maladies infectieuses et immunitaires
  • Maladies auto-immunes
  • Maladies du système immunitaire
  • Médiateurs immunologiques : cytokines et chimiokines
  • Système immunitaire
Nutrition et métabolisme
  • Maladie de Crohn
  • Métabolisme
  • Métabolisme énergétique
  • Toxicologie

Projets de recherche

  • Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
  • La nanoparticule PapMV-fMLF, une nouvelle classe d'immunostimulant pour prévenir les infections respiratoires virales - Fondation du CHU de Québec, Ministère de l'Économie et de l'Innovation - Programme de soutien aux organismes de recherche et d’innovation (PSO) - Volet 2 : Soutien aux projets, co-chercheur - 2021-12-17 au 2022-12-16
  • Surveillance des réponses immunitaires au vaccin contre la COVID-19 chez les personnes vivant avec le VIH-1 - Instituts de recherche en santé du Canada - Subvention de fonctionnement:Nouveaux besoins prioritaires en recherche sur la COVID-19, co-chercheur - 2021-12-01 au 2022-11-30
  • Salaire d'un professeur - CHU de Québec – Université Laval – CHUL, chercheur principal - 2014-08-01 au 2022-06-30
  • Métabolisme bioénergétique et réponse fonctionnelle des cellules inflammatoires : Étude de facteurs endogènes et environnementaux - Fonds de recherche du Québec - Santé - Chercheur-boursier Juniors 1 et 2, Seniors, chercheur principal - 2018-07-01 au 2022-06-30
  • Defining the Effects of Endocrine-Disrupting chemicals on the cellular metabolism of inflammatory cells. - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2015-04-01 au 2022-03-31
  • Développement d’une méthode fiable pour la détection d’anticorps contre Malassezia - Fondation de l'Université Laval, chercheur principal - 2020-04-01 au 2022-03-31
  • Bourse Concert pour la vie - Fondation du CHU de Québec, chercheur principal - 2020-11-13 au 2021-11-12
  • Étude de la réponse immune contre Malassezia dans la maladie de Crohn - Fondation de l'Université Laval, chercheur principal - 2018-11-01 au 2021-10-31
  • Réponse immunitaire contre le champignon Malassezia dans la prostate - Fondation de l'Université Laval, chercheur principal - 2019-11-01 au 2021-10-31
  • CUASF-BCC Research Grant Program - Association canadienne d'urologie, co-chercheur - 2020-06-06 au 2021-06-05
  • Repositionnement du fumarate de diméthyle pour traiter la COVID-19: une molécule à double action au potentiel antiviral et anti-inflammatoire - Fonds de recherche du Québec - Santé - Réseaux thématiques de recherche, Université de Montréal, co-chercheur - 2020-05-11 au 2021-04-30
  • Profil moléculaire sanguin de patientes souffrant de lupus - CHU de Québec – Université Laval – CHUL - Développement de la recherche (RFI), co-chercheur - 2019-04-01 au 2021-03-31
  • Évaluation du profil de cytokines par les leucocytes sanguins : étude d'un cas clinique - Fondation du CHU de Québec, chercheur principal - 2020-04-07 au 2021-03-31

Publications

  • Glucuronidated Metabolites of Bisphenols A and S Alter the Properties of Normal Urothelial and Bladder Cancer Cells, Ève Pellerin, Félix-Antoine Pellerin, Stéphane Chabaud, Frédéric Pouliot, Martin Pelletier, Stéphane Bolduc, International Journal of Molecular Sciences, 2022, 10.3390/ijms232112859
  • Bisphenols A and S Alter the Bioenergetics and Behaviours of Normal Urothelial and Bladder Cancer Cells, Ève Pellerin, Félix-Antoine Pellerin, Stéphane Chabaud, Frédéric Pouliot, Stéphane Bolduc, Martin Pelletier, Cancers, 2022, 10.3390/cancers14164011
  • Impacts of endocrine-disrupting chemicals on prostate function and cancer, Aurélie Lacouture, Camille Lafront, Cindy Peillex, Martin Pelletier, Étienne Audet-Walsh, Environmental Research, 2022, 10.1016/j.envres.2021.112085
  • Heat-Inactivation of Fetal and Newborn Sera Did Not Impair the Expansion and Scaffold Engineering Potentials of Fibroblasts, Félix-Antoine Pellerin, Christophe Caneparo, Ève Pellerin, Stéphane Chabaud, Martin Pelletier, Stéphane Bolduc, Bioengineering, 2021, 10.3390/bioengineering8110184
  • Bisphenol A Alters the Energy Metabolism of Stromal Cells and Could Promote Bladder Cancer Progression, Ève Pellerin, Stéphane Chabaud, Frédéric Pouliot, Martin Pelletier, Stéphane Bolduc, Cancers, 2021, 10.3390/cancers13215461
  • Expression of the myeloid inhibitory receptor CLEC12A correlates with disease activity and cytokines in early rheumatoid arthritis, Myriam Vaillancourt, Philippe Desaulniers, Guillaume Paré, Nathalie Pagé, Asmaa Lachhab, Anthony Kerever, Anne-Sophie Julien, Nathalie Amiable, Martin Pelletier, Philippe A. Tessier, Louis Bessette, Laëtitia Michou, Paul R. Fortin, Maria J. Fernandes, Scientific Reports, 2021, 10.1038/s41598-021-90631-7
  • Bisphenol A, bisphenol S and their glucuronidated metabolites modulate glycolysis and functional responses of human neutrophils, Cindy Peillex, Anthony Kerever, Asmaa Lachhab, Martin Pelletier, Environmental Research, 2021, 10.1016/j.envres.2020.110336
  • Colchicine for community-treated patients with COVID-19 (COLCORONA): a phase 3, randomised, double-blinded, adaptive, placebo-controlled, multicentre trial, , The Lancet Respiratory Medicine, 2021, 10.1016/s2213-2600(21)00222-8
  • Endocrine-disrupting effects of bisphenols on urological cancers, Eve Pellerin, Christophe Caneparo, Stéphane Chabaud, Stéphane Bolduc, Martin Pelletier, Environmental Research, 2021, 10.1016/j.envres.2020.110485
  • The evaluation of cytokines to help establish diagnosis and guide treatment of autoinflammatory and autoimmune diseases, Anne-Laure Chetaille Nézondet, Patrice E Poubelle, Martin Pelletier, Journal of Leukocyte Biology, 2020, 10.1002/JLB.5MR0120-218RRR
  • The impact and toxicity of glyphosate and glyphosate-based herbicides on health and immunity, Cindy Peillex, Martin Pelletier, Journal of Immunotoxicology, 2020, 10.1080/1547691X.2020.1804492
  • The use of leukocytes’ secretome to individually target biological therapy in autoimmune arthritis: a case report, Patrice E. Poubelle, Nathalie Pagé, Marie‐Pier Longchamps, Natalia Sampaio Moura, David B. Beck, Ivona Aksentijevich, Philippe A. Tessier, Martin Pelletier, Clinical and Translational Medicine, 2019, 10.1186/s40169-019-0236-7
  • Anti-mitochondrial autoantibodies in systemic lupus erythematosus and their association with disease manifestations, Becker, Y., Loignon, R.-C., Julien, A.-S., Marcoux, G., Allaeys, I., Lévesque, T., Rollet-Labelle, E., Benk-Fortin, H., Cloutier, N., Melki, I., Eder, L., Wagner, É., Pelletier, M., Hajj, H.E., Tremblay, M.-È., Belleannée, C., Hébert, M.-J., Dieudé, M., Rauch, J., Fortin, P.R., Boilard, E., Scientific Reports, 2019, 10.1038/s41598-019-40900-3
  • Tumor-associated macrophages enhance tumor hypoxia and aerobic glycolysis, Jeong, H., Kim, S., Hong, B.-J., Lee, C.-J., Kim, Y.-E., Bok, S., Oh, J.-M., Gwak, S.-H., Yoo, M.Y., Lee, M.S., Chung, S.-J., Defrêne, J., Tessier, P., Pelletier, M., Jeon, H., Roh, T.-Y., Kim, B., Kim, K.H., Ju, J.H., Kim, S., Lee, Y.-J., Kim, D.-W., Kim, I.H., Kim, H.J., Park, J.-W., Lee, Y.-S., Lee, J.S., Cheon, G.J., Weissman, I.L., Chung, D.H., Jeon, Y.K., Ahn, G.-O., Cancer Research, 2019, 10.1158/0008-5472.CAN-18-2545
  • Quinoline-3-carboxamides such as tasquinimod are not specific inhibitors of S100A9, Martin Pelletier, Jean-Christophe Simard, Denis Girard, Philippe A. Tessier, Blood Advances, 2018, 10.1182/bloodadvances.2018016667
  • S100A9 induces differentiation of acute myeloid leukemia cells through TLR4, Malika Laouedj, Mélanie R. Tardif, Laurine Gil, Marie-Astrid Raquil, Asmaa Lachhab, Martin Pelletier, Philippe A. Tessier, Frédéric Barabé, Blood, 2017, 10.1182/blood-2016-09-738005
  • S100A9 potentiates the activation of neutrophils by the etiological agent of gout, monosodium urate crystals, Rousseau, L.-S., Paré, G., Lachhab, A., Naccache, P.H., Marceau, F., Tessier, P., Pelletier, M., Fernandes, M., Journal of Leukocyte Biology, 2017, 10.1189/jlb.3MA0117-020R
  • Critical role of fatty acid metabolism in ILC2-mediated barrier protection during malnutrition and helminth infection, Christoph Wilhelm, Oliver J. Harrison, Vanessa Schmitt, Martin Pelletier, Sean P. Spencer, Joseph F. Urban, Jr., Michelle Ploch, Thirumalai R. Ramalingam, Richard M. Siegel, Yasmine Belkaid, Journal of Experimental Medicine, 2016, 10.1084/jem.20151448
  • Erratum: Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type i IFN production (Journal of Clinical Investigation (2015) 125:11 (4196-4211) DOI: 10.1172/JCI81260), Brehm, A., Liu, Y., Sheikh, A., Marrero, B., Omoyinmi, E., Zhou, Q., Montealegre, G., Biancotto, A., Reinhardt, A., De Jesus, A.A., Pelletier, M., Tsai, W.L., Remmers, E.F., Kardava, L., Hill, S., Kim, H., Lachmann, H.J., Megarbane, A., Chae, J.J., Brady, J., Castillo, R.D., Brown, D., Casano, A.V., Gao, L., Chapelle, D., Huang, Y., Stone, D., Chen, Y., Sotzny, F., Lee, C.-C.R., Kastner, D.L., Torrelo, A., Zlotogorski, A., Moir, S., Gadina, M., McCoy, P., Wesley, R., Rother, K.I., Hildebrand, P.W., Brogan, P., Krüger, E., Aksentijevich, I., Goldbach-Mansky, R., Journal of Clinical Investigation, 2016, 10.1172/JCI86020
  • Le profil de sécrétion de cytokines par les leucocytes sanguins aide au diagnostic et au traitement des patients atteints de maladies auto-inflammatoires, Nézondet-Chetaille, A.L., Longchamps, M.P., Pagé, N., Leclerc, M., Tessier, P., Pelletier, M., Revue du Rhumatisme (Edition Francaise), 2016, 10.1016/S1169-8330(16)30609-3
  • Recruitment of A20 by the C-terminal domain of NEMO suppresses NF-κB activation and autoinflammatory disease, Zilberman-Rudenko, J., Shawver, L.M., Wessel, A.W., Luo, Y., Pelletier, M., Tsai, W.L., Lee, Y., Vonortas, S., Cheng, L., Ashwell, J.D., Orange, J.S., Siegel, R.M., Hanson, E.P., Proceedings of the National Academy of Sciences of the United States of America, 2016, 10.1073/pnas.1518163113
  • Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type i IFN production, Brehm, A., Liu, Y., Sheikh, A., Marrero, B., Omoyinmi, E., Zhou, Q., Montealegre, G., Biancotto, A., Reinhardt, A., De Jesus, A.A., Pelletier, M., Tsai, W.L., Remmers, E.F., Kardava, L., Hill, S., Kim, H., Lachmann, H.J., Megarbane, A., Chae, J.J., Brady, J., Castillo, R.D., Brown, D., Casano, A.V., Gao, L., Chapelle, D., Huang, Y., Stone, D., Chen, Y., Sotzny, F., Lee, C.-C.R., Kastner, D.L., Torrelo, A., Zlotogorski, A., Moir, S., Gadina, M., McCoy, P., Wesley, R., Rother, K., Hildebrand, P.W., Brogan, P., Krüger, E., Aksentijevich, I., Goldbach-Mansky, R., Journal of Clinical Investigation, 2015, 10.1172/JCI81260
  • Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects, Traba, J., Kwarteng-Siaw, M., Okoli, T.C., Li, J., Huffstutler, R.D., Bray, A., Waclawiw, M.A., Han, K., Pelletier, M., Sauve, A.A., Siegel, R.M., Sack, M.N., Journal of Clinical Investigation, 2015, 10.1172/JCI83260
  • The TNF-family ligand TL1A and its receptor DR3 promote T cell-mediated allergic immunopathology by enhancing differentiation and pathogenicity of IL-9-producing T cells, Richard, A.C., Tan, C., Hawley, E.T., Gomez-Rodriguez, J., Goswami, R., Yang, X.-P., Cruz, A.C., Penumetcha, P., Hayes, E.T., Pelletier, M., Gabay, O., Walsh, M., Ferdinand, J.R., Keane-Myers, A., Choi, Y., O'Shea, J.J., Al-Shamkhani, A., Kaplan, M.H., Gery, I., Siegel, R.M., Meylan, F., Journal of Immunology, 2015, 10.4049/jimmunol.1401220
  • Extracellular flux analysis to monitor glycolytic rates and mitochondrial oxygen consumption, Pelletier, M., Billingham, L.K., Ramaswamy, M., Siegel, R.M., Methods in Enzymology, 2014, 10.1016/B978-0-12-416618-9.00007-8
  • The TNF-family cytokine TL1A promotes allergic immunopathology through group 2 innate lymphoid cells, Meylan, F., Hawley, E.T., Barron, L., Barlow, J.L., Penumetcha, P., Pelletier, M., Sciumè, G., Richard, A.C., Hayes, E.T., Gomez-Rodriguez, J., Chen, X., Paul, W.E., Wynn, T.A., McKenzie, A.N.J., Siegel, R.M., Mucosal Immunology, 2014, 10.1038/mi.2013.114
  • New tricks from an old dog: Mitochondrial redox signaling in cellular inflammation, Pelletier, M., Lepow, T.S., Billingham, L.K., Murphy, M.P., Siegel, R.M., Seminars in Immunology, 2012, 10.1016/j.smim.2013.01.002
  • Human neutrophils interact with both 6-sulfo LacNAc+ DC and NK cells to amplify NK-derived IFNγ: Role of CD18, ICAM-1, and ICAM-3, Costantini, C., Calzetti, F., Perbellini, O., Micheletti, A., Scarponi, C., Lonardi, S., Pelletier, M., Schakel, K., Pizzolo, G., Facchetti, F., Vermi, W., Albanesi, C., Cassatella, M.A., Blood, 2011, 10.1182/blood-2010-06-287243
  • Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS), Bulua, A.C., Simon, A., Maddipati, R., Pelletier, M., Park, H., Kim, K.-Y., Sack, M.N., Kastner, D.L., Siegel, R.M., Journal of Experimental Medicine, 2011, 10.1084/jem.20102049
  • Toll-like receptor-3-activated human mesenchymal stromal cells significantly prolong the survival and function of neutrophils, Cassatella, M.A., Mosna, F., Micheletti, A., Lisi, V., Tamassia, N., Cont, C., Calzetti, F., Pelletier, M., Pizzolo, G., Krampera, M., Stem Cells, 2011, 10.1002/stem.651
  • Evidence for a cross-talk between human neutrophils and Th17 cells, Pelletier, M., Maggi, L., Micheletti, A., Lazzeri, E., Tamassia, N., Costantini, C., Cosmi, L., Lunardi, C., Annunziato, F., Romagnani, S., Cassatella, M.A., Blood, 2010, 10.1182/blood-2009-04-216085
  • Modulation of human neutrophil survival and antigen expression by activated CD4+ and CD8+ T cells, Pelletier, M., Micheletti, A., Cassatella, M.A., Journal of Leukocyte Biology, 2010, 10.1189/jlb.0310172
  • Wishing away inflammation? New links between serotonin and TNF signaling, Pelletier, M., Siegel, R.M., Molecular Interventions, 2009, 10.1124/mi.9.6.5
  • Angiopoietin chemotactic activities on neutrophils are regulated by PI-3K activation, Brkovic, A., Pelletier, M., Girard, D., Sirois, M.G., Journal of Leukocyte Biology, 2007, 10.1189/jlb.0906580
  • Biological functions of interleukin-21 and its role in inflammation, Pelletier, M., Girard, D., TheScientificWorldJournal, 2007, 10.1100/tsw.2007.275
  • Molecular mechanisms involved in interleukin-4-induced human neutrophils: Expression and regulation of suppressor of cytokine signaling, Ratthé, C., Pelletier, M., Chiasson, S., Girard, D., Journal of Leukocyte Biology, 2007, 10.1189/jlb.0306209
  • Differential effects of IL-15 and IL-21 in myeloid (CD11b+) and lymphoid (CD11b-) bone marrow cells, Pelletier, M., Girard, D., Journal of Immunology, 2006, 10.4049/jimmunol.177.1.100
  • Interleukin-15 increases neutrophil adhesion onto human respiratory epithelial A549 cells and attracts neutrophils in vivo, Pelletier, M., Girard, D., Clinical and Experimental Immunology, 2005, 10.1111/j.1365-2249.2005.02861.x
  • In vivo and in vitro roles of IL-21 in inflammation, Pelletier, M., Bouchard, A., Girard, D., Journal of Immunology, 2004, 10.4049/jimmunol.173.12.7521
  • Activation of human epithelial lung A549 cells by the pollutant sodium sulfite: Enhancement of neutrophil adhesion, Pelletier, M., Lavastre, V., Girard, D., Toxicological Sciences, 2002, 10.1093/toxsci/69.1.210
  • Activation of human neutrophils by the pollutant sodium sulfite: Effect on cytokine production, chemotaxis, and cell surface expression of cell adhesion molecules, Ratthé, C., Pelletier, M., Roberge, C.J., Girard, D., Clinical Immunology, 2002, 10.1006/clim.2002.5282
  • Dieldrin induces human neutrophil superoxide production via protein kinases C and tyrosine kinases, Pelletier, M., Girard, D., Human and Experimental Toxicology, 2002, 10.1191/0960327102ht272oa
  • Mechanisms involved in interleukin-15-induced suppression of human neutrophil apoptosis: Role of the anti-apoptotic Mcl-1 protein and several kinases including Janus kinase-2, p38 mitogen-activated protein kinase and extracellular signal-regulated kinases-1/2, Pelletier, M., Ratthé, C., Girard, D., FEBS Letters, 2002, 10.1016/S0014-5793(02)03668-2
  • Mechanisms involved in spontaneous and Viscum album agglutinin-I-induced human neutrophil apoptosis: Viscum album agglutinin-I accelerates the loss of antiapoptotic Mcl-1 expression and the degradation of cytoskeletal paxillin and vimentin proteins via caspases, Lavastre, V., Pelletier, M., Saller, R., Hostanska, K., Girard, D., Journal of Immunology, 2002, 10.4049/jimmunol.168.3.1419
  • Toxaphene, but not beryllium, induces human neutrophil chemotaxis and apoptosis via reactive oxygen species (ROS): Involvement of caspases and ROS in the degradation of cytoskeletal proteins, Lavastre, V., Roberge, C.J., Pelletier, M., Gauthier, M., Girard, D., Clinical Immunology, 2002, 10.1006/clim.2002.5226
  • Activation of human neutrophils by technical toxaphene, Gauthier, M., Roberge, C.J., Pelletier, M., Tessier, P.A., Girard, D., Clinical Immunology, 2001, 10.1006/clim.2000.4946
  • Activation of human neutrophils in vitro and dieldrin-induced neutrophilic inflammation in vivo, Pelletier, M., Roberge, C.J., Gauthier, M., Vandal, K., Tessier, P.A., Girard, D., Journal of Leukocyte Biology, 2001
  • Modulation of interleukin-15-induced human neutrophil responses by the plant lectin Viscum album agglutinin-I, Pelletier, M., Lavastre, V., Savoie, A., Ratthé, C., Saller, R., Hostanska, K., Girard, D., Clinical Immunology, 2001, 10.1006/clim.2001.5105
  • Activation of human neutrophils by the air pollutant sodium sulfite (NA2SO3): Comparison with immature promyelocytic HL-60 and DMSO-differentiated HL-60 cells reveals that NA2SO3 is a neutrophil but not a HL-60 cell agonist, Pelletier, M., Savoie, A., Girard, D., Clinical Immunology, 2000, 10.1006/clim.2000.4883
  • Activation of human neutrophils by the plant lectin Viscum album agglutinin-I: Modulation of de novo protein synthesis and evidence that caspases are involved in induction of apoptosis, Savoie, A., Lavastre, V., Pelletier, M., Hajto, T., Hostanska, K., Girard, D., Journal of Leukocyte Biology, 2000
  • Activation of superoxide production by promyelocytic HL-60 cells with sodium sulfite, Pelletier, M., Girard, D., Journal of Investigative Medicine, 1999
  • Human neutrophil gene expression could be modulated by chemicals of environmental concern, Pelletier, M., Savoie, A., Girard, D., Journal of Investigative Medicine, 1999
  • Sodium sulfite increases the production of interleukin-8 (IL-8) but not tumor necrosis factor-alpha (TNF-α) in human neutrophils, Savoie, A., Pelletier, M., Girard, D., Journal of Investigative Medicine, 1999
  • Functional responses of human neutrophils to sodium sulfite (Na2SO3) in vitro, Labbé, P., Pelletier, M., Omara, F.O., Girard, D., Human and Experimental Toxicology, 1998, 10.1177/096032719801701103

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Pier-Olivier Leblanc - Maîtrise avec mémoire - En cours
  • Asmaa Lachhab - Doctorat - En cours
  • Emma Bourgeault - Maîtrise avec mémoire - En cours
  • Louis-Simon Rousseau - Maîtrise avec mémoire - 2017/09
  • Anthony Kerever - Maîtrise avec mémoire - 2018/09
  • Marie-Pier Longchamps - Maîtrise avec mémoire - 2019/01
  • Eve Pellerin - Maîtrise avec mémoire - 2022/09

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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