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Marc Pouliot

Professeur titulaire

Marc Pouliot
marc.pouliot@fmed.ulaval.ca
Centre de recherche du CHU de Québec - Université Laval
Centre de recherche en arthrite (ARThrite)
Centre de recherche en données massives
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Contribution à la recherche

Thématiques de recherche de la Faculté de médecine

  • Bioinformatique / données massives (big data)
  • Immunologie-infectiologie
  • Transfert des connaissances

Domaines de recherche

  • Immunité innée
    • Recherche clinique
  • Auto-immunité
    • Sciences médicales, de la santé et de la vie
  • Maladies auto-immunes
    • Recherche orientée vers le patient

Projets de recherche en cours

  • ICanCME: Interdisciplinary Canadian Collaborative Myalgic Encephalomyelitis Research Network - Instituts de recherche en santé du Canada - Subvention Catalyseur de réseau sur l’encéphalomyélite myalgique (EM), Université de Montréal, co-chercheur - 2024-09-01 au 2029-08-31
  • Demande de support financier pour la tenue du congrès '16th World Congress on Inflammation'. - Fonds de recherche du Québec - Santé - Soutien à l'organisation de congrès internationaux du Cercle des Ambassadeurs de Québec et des Fonds de recherche du Québec, chercheur principal - 2023-11-10 au 2025-06-30

Financements des 2 dernières années

  • FcgRI as a potential therapeutic target in inflammatory arthritis - La société d'arthrite, chercheur principal - 2022-01-01 au 2025-03-31
  • Repousser les frontières de l'étude de la biologie à l'échelle nanométrique en conditions naturelles - Fondation Canadienne pour l'innovation (La), CIUSSS - CN - CERVO, Ministère de la Santé et des Services sociaux - Fonds d'innovation (FI), co-chercheur - 2023-07-01 au 2025-03-31
  • Surveillance des réponses immunitaires au vaccin contre la COVID-19 chez les personnes vivant avec le VIH-1 - Instituts de recherche en santé du Canada - Subvention de fonctionnement:Nouveaux besoins prioritaires en recherche sur la COVID-19, co-chercheur - 2021-12-01 au 2022-11-30

Publications

  • Expression and regulation of glycogen synthase kinase 3 in human neutrophils, Pouliot, M., Boilard, E., Rollet-Labelle, E., Cloutier, N., Giambelluca, M.S., International Journal of Biochemistry and Cell Biology, 2013, 10.1016/j.biocel.2013.09.001
  • Colocalization of cytosolic phospholipase A2, 5-lipoxygenase, and 5-lipoxygenase-activating protein at the nuclear membrane of A23187-stimulated human neutrophils, Borgeat, P., Weech, P.K., Mccoll, S.R., Mancini, J.A., Krump, E., Mcdonald, P.P., Pouliot, M., European Journal of Biochemistry, 1996
  • Lipoxin A4 and aspirin-triggered 15-epi-LXA4 inhibit tumor necrosis factor-α-initiated neutrophil responses and trafficking: Novel regulators of a cytokine-chemokine axis relevant to periodontal diseases, Serhan, C.N., Pouliot, M., Journal of Periodontal Research, 1999
  • Cutting edge: Nociceptin stimulates neutrophil chemotaxis and recruitment: Inhibition by aspirin-triggered-15-epi-lipoxin A4, Pouliot, M., Chiang, N., Fierro, I.M., Serhan, C.N., Journal of Immunology, 2001
  • Impact of anti-inflammatory agents on the gene expression profile of stimulated human neutrophils: Unraveling endogenous resolution pathways, Pouliot, M., Dussault, A.-A., Laflamme, C., Michaud, A., Dumas, A., St-Onge, M., PLoS ONE, 2009, 10.1371/journal.pone.0004902
  • Hypoxia induces epithelial amphiregulin gene expression in a CREB-dependent manner, Taylor, C.T., Lee, S.B., Pouliot, M., Cummins, E., Comerford, K.M., Kieran, N., Leonard, M.O., O'Reilly, S.M., American Journal of Physiology - Cell Physiology, 2006, 10.1152/ajpcell.00278.2005
  • Evidence of impairment of normal inflammatory reaction by a high-fat diet, Pouliot, M., Boilard, E., Cloutier, N., Giambelluca, M.S., Bertheau-Mailhot, G., Laflamme, C., Genes and Immunity, 2014, 10.1038/gene.2014.8
  • Augmented Angiogenic Factors Expression via FP Signaling Pathways in Peritoneal Endometriosis., , The Journal of clinical endocrinology and metabolism, 2016, 10.1210/jc.2016-1569
  • Proteinase-activated receptor-2 up-regulation by Fcγ-receptor activation in human neutrophils, Pouliot, M., Naccache, P.H., Marois, L., Rollet-Labelle, E., Laflamme, C., Lagarde, S., St-Onge, M., FASEB Journal, 2010, 10.1096/fj.09-146167
  • Induction by Chemokines of Lipid Mediator Synthesis in Granulocyte-Macrophage Colony-Stimulating Factor-Treated Human Neutrophils, McColl, S.R., Borgeat, P., Pouliot, M., McDonald, P.P., Journal of Immunology, 1993
  • Erratum:Platelet microparticles are internalized in neutrophilsvia the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA (Proceedings of the National Academy of Sciences of the United States of America (2015) 112 (E3564-E3573) DOI 10.1073/pnas.1507905112), Boilard, E., Gelb, M.H., Soulet, D., Provost, P., Pouliot, M., Lambeau, G., Poubelle, P.E., Tremblay, J.J., Allaeys, I., Rousseau, M., Rollet-Labelle, E., Lévesque, T., Mendoza-Villarroel, R.E., Laffont, B., Cloutier, N., Belleannée, C., Bollinger, J., Naika, G.S., Boudreau, L.H., Duchez, A.-C., Proceedings of the National Academy of Sciences of the United States of America, 2015, 10.1073/pnas.1522504112
  • Adenosine up-regulates cyclooxygenase-2 in human granulocytes: Impact on the balance of eicosanoid generation, Borgeat, P., Naccache, P.H., Massé, M., Fiset, M.-É., Pouliot, M., Journal of Immunology, 2002
  • Oncostatin M decreases interleukin-1 β secretion by human synovial fibroblasts and attenuates an acute inflammatory reaction in vivo, Pouliot, M., Laflamme, C., Lagarde, S., Dumas, A., Journal of Cellular and Molecular Medicine, 2012, 10.1111/j.1582-4934.2011.01412.x
  • The Toll-like receptor 7/8-ligand resiquimod (R-848) primes human neutrophils for leukotriene B4, prostaglandin E2 and platelet-activating factor biosynthesis, Borgeat, P., Pouliot, M., Leclerc, P., Borgeat, M., Picard, S., Hattermann, K., FASEB Journal, 2007, 10.1096/fj.06-7457com
  • Regulation of Tumor Necrosis Factor-α and IL-1β Synthesis by Thromboxane A2 in Nonadherent Human Monocytes, James, M.J., Cleland, L.G., Pouliot, M., Caughey, G.E., Journal of Immunology, 1997
  • Immunomodulatory impact of the A2A adenosine receptor on the profile of chemokines produced by neutrophils, Pouliot, M., Boulanger, J., Bouchard, L., Laflamme, C., Dussault, A.-A., St-Onge, M., McColl, S.R., FASEB Journal, 2006, 10.1096/fj.05-4804fje
  • Platelets release mitochondrial antigens in systemic lupus erythematosus., , Science translational medicine, 2021, 10.1126/scitranslmed.aav5928
  • Leukotriene synthesis in calcium-depleted human neutrophils: Arachidonic acid release correlates with calcium influx, Borgeat, P., Naccache, P.H., Pouliot, M., Krump, E., Biochemical Journal, 1995
  • Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase a to promote inflammation, Boilard, E., Gelb, M.H., Semple, J.W., Lacroix, S., Thibault, L., Guderley, H., Nigrovic, P.A., Garraud, O., Cognasse, F., Hamzeh-Cognasse, H., Pouliot, M., Farndale, R.W., Lambeau, G., Marcoux, G., Laflamme, C., Lévesque, T., Naika, G.S., Rousseau, M., Paré, A., Bollinger, J., Martin, N., Soulet, D., Cloutier, N., Duchez, A.-C., Boudreau, L.H., Blood, 2014, 10.1182/blood-2014-05-573543
  • Lipoxin A4 analogues inhibit leukocyte recruitment to Porphyromonas gingivalis: A role for cyclooxygenase-2 and lipoxins in periodontal disease, Serhan, C.N., Van Dyke, T.E., Petasis, N.A., Clish, C.B., Pouliot, M., Biochemistry, 2000, 10.1021/bi992551b
  • Pro-inflammatory type-1 and anti-inflammatory type-2 macrophages differentially modulate cell survival and invasion of human bladder carcinoma T24 cells, Reyes-Moreno, C., Pouliot, M., Carrier, C., Asselin, T., Dumas, G., Dufresne, M., Molecular Immunology, 2011, 10.1016/j.molimm.2011.04.022
  • Abnormal Expression of Prostaglandins E2 and F2 α Receptors and Transporters in Patients with Endometriosis, Pouliot, M., Akoum, A., Bourcier, N., Rakhila, H., BioMed Research International, 2015, 10.1155/2015/808146
  • Lipoxin (LX)A4 and aspirin-triggered 15-epi-LXA4 inhibit tumor necrosis factor 1α-initiated neutrophil responses and trafficking: Regulators of a cytokine-chemokine axis, Serhan, C.N., Petasis, N.A., Pouliot, M., Hachicha, M., Journal of Experimental Medicine, 1999, 10.1084/jem.189.12.1923
  • Characterization of the Na/HCO3 - cotransport in human neutrophils, Aiello, E.A., Pouliot, M., Gende, O.A., Orlowski, A., Ciancio, M.C., Giambelluca, M.S., Cellular Physiology and Biochemistry, 2014, 10.1159/000358669
  • Granulocyte/macrophage colony-stimulating factor stimulates the expression of the 5-lipoxygenase-activating protein (FLAP) in human neutrophils, McColl, S.R., Borgeat, P., McDonald, P.P., Pouliot, M., Journal of Experimental Medicine, 1994
  • Characterization of prostaglandin E2 generation through the cyclooxygenase (COX)-2 pathway in human neutrophils, Pouliot, M., Borgeat, P., Cleland, L.G., Caughey, G.E., James, M.J., Laflamme, C., Dussault, A.-A., Bouchard, L., Picard, S., Biarc, J., Flamand, N., St-Onge, M., Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 2007, 10.1016/j.bbalip.2007.06.002
  • Promotion of angiogenesis and proliferation cytokines patterns in peritoneal fluid from women with endometriosis, Pouliot, M., Akoum, A., Lemyre, M., Leboeuf, M., Bergeron, M.-E., Al-Akoum, M., Rakhila, H., Journal of Reproductive Immunology, 2016, 10.1016/j.jri.2016.01.005
  • Human neutrophils as a source of nociceptin: A novel link between pain and inflammation, Pouliot, M., Poubelle, P.E., Gilbert, C., Fiset, M.-É., Biochemistry, 2003, 10.1021/bi0300635
  • Enhancement by GM-CSF of agonist-induced 5-lipoxygenase activation in human neutrophils involves protein synthesis and gene transcription, Borgeat, P., Pouliot, M., McDonald, P.P., Journal of Lipid Mediators, 1992
  • Expression and activity of prostaglandin endoperoxide synthase-2 in agonist-activated human neutrophils, Naccache, P.H., McColl, S.R., Maclouf, J., Créminon, C., Bourgoin, S., Poubelle, P.E., Borgeat, P., Gilbert, C., Pouliot, M., FASEB Journal, 1998
  • Nucleobindin co-localizes and associates with cyclooxygenase (COX)-2 in human neutrophils, Pouliot, M., Laflamme, C., Dussault, A.-A., Gilbert, C., St.-Onge, M., Biarc, J., Leclerc, P., PLoS ONE, 2008, 10.1371/journal.pone.0002229
  • Potentiation of neutrophil cyclooxygenase-2 by adenosine: An early anti-inflammatory signal, Pouliot, M., Borgeat, P., Ledent, C., Picard, S., Laflamme, C., Dussault, A.-A., St-Onge, M., Leclerc, P., Cadieux, J.-S., Journal of Cell Science, 2005, 10.1242/jcs.01737
  • The pronociceptive effect of proteinase-activated receptor-4 stimulation in rat knee joints is dependent on mast cell activation, McDougall, J.J., Pouliot, M., Dumas, A., Lagarde, S., Zhan, S., Russell, F.A., Pain, 2011, 10.1016/j.pain.2010.10.038
  • IgG-aggregates rapidly up-regulate FcgRI expression at the surface of human neutrophils in a FcgRII-dependent fashion: A crucial role for FcgRI in the generation of reactive oxygen species, Marc Pouliot, Eric Boilard, Paul R. Fortin, Cynthia Laflamme, Sandrine Huot, 2020, 10.1101/2020.03.04.975094
  • Osteoblast retraction induced by adherent neutrophils promotes osteoclast bone resorption: Implication for altered bone remodeling in chronic gout, Poubelle, P.E., Borgeat, P., Pouliot, M., Picard, S., Rusu, D., Allaeys, I., Laboratory Investigation, 2011, 10.1038/labinvest.2011.46
  • Neutrophil: Foe or friend? | Le neutrophile: Ennemi ou ami?, Pouliot, M., Dumas, A., Medecine/Sciences, 2009
  • Early tyrosine phosphorylation events following adenosine A2A receptor in human neutrophils: identification of regulated pathways., , Journal of leukocyte biology, 2017, 10.1189/jlb.2vma1216-517r
  • Inhibition of Prostaglandin Endoperoxide Synthase-2 Expression in Stimulated Human Monocytes by Inhibitors of p38 Mitogen-Activated Protein Kinase, James, M.J., Cleland, L.G., Lee, J.C., Baillargeon, J., Pouliot, M., Journal of Immunology, 1997
  • A functional toll-like receptor 8 variant is associated with HIV disease restriction, Schumann, R.R., Hattermann, K., Pruss, A., Schreier, E., Oh, N., Borgeat, P., Pouliot, M., Storek, A., Neumann, K., Eckert, J.K., Jessen, H., Poggensee, G., Kücherer, C., Hamouda, O., Taube, S., Oh, D.-Y., Journal of Infectious Diseases, 2008, 10.1086/590431
  • TNF-α expression in neutrophils and its regulation by glycogen synthase kinase-3: A potentiating role for lithium, Pouliot, M., Servant, M.J., Rollet-Labelle, E., Laflamme, C., Bertheau-Mailhot, G., Giambelluca, M.S., FASEB Journal, 2014, 10.1096/fj.14-251900
  • Granulocyte-macrophage colony-stimulating factor enhances 5-lipoxygenase levels in human polymorphonuclear leukocytes, McColl, S.R., Borgeat, P., Khamzina, L., McDonald, P.P., Pouliot, M., Journal of Immunology, 1994
  • Crystal-induced neutrophil activation: VIII. Immediate production of prostaglandin E2 mediated by constitutive cyclooxygenase 2 in human neutrophils stimulated by urate crystals, Naccache, P.H., Pouliot, M., Borgeat, P., Poubelle, P.E., Gilbert, C., Arthritis and Rheumatism, 2003, 10.1002/art.10851
  • Effects of pyrrophenone, an inhibitor of group IVA phospholipase A 2, on eicosanoid and PAF biosynthesis in human neutrophils, Borgeat, P., Bourgoin, S.G., Pouliot, M., Lemieux, L., Picard, S., Flamand, N., British Journal of Pharmacology, 2006, 10.1038/sj.bjp.0706879
  • Monosodium urate microcrystals induce cyclooxygenase-2 in human monocytes, Cleland, L.G., Naccache, P.H., McColl, S.R., James, M.J., Pouliot, M., Blood, 1998
  • Age-related decline of the acute local inflammation response: a mitigating role for the adenosine A2A receptor., , Aging, 2017, 10.18632/aging.101303
  • Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA, Boilard, E., Gelb, M.H., Soulet, D., Provost, P., Pouliot, M., Lambeau, G., Poubelle, P.E., Tremblay, J.J., Allaeys, I., Rousseau, M., Rollet-Labelle, E., Lévesque, T., Mendoza-Villarroel, R.E., Laffont, B., Cloutier, N., Belleannée, C., Bollinger, J., Boudreau, L.H., Duchez, A.-C., Proceedings of the National Academy of Sciences of the United States of America, 2015, 10.1073/pnas.1507905112
  • Rapid and simple comparison of messenger RNA levels using real-time PCR, Pouliot, M., Dussault, A.-A., Biological Procedures Online, 2006, 10.1251/bpo114

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2020/05
  • Sandrine Huot - Doctorat - En cours
  • Lisa Auclert - Maîtrise avec mémoire - 2020/09

Encadrement d'étudiant(e)s

Direction de recherche dans les domaines suivants :

  • Biologie cellulaire et moléculaire
  • Médecine moléculaire
  • Microbiologie-immunologie
  • Sciences cliniques et biomédicales

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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