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Marc Pouliot

Professeur titulaire

Marc Pouliot
marc.pouliot@fmed.ulaval.ca
Centre de recherche du CHU de Québec - Université Laval
Centre de recherche en arthrite (ARThrite)
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Bioinformatique / données massives (big data)
Immunologie-infectiologie
Transfert des connaissances

Domaines et intérêts de recherche du (de la) professeur(e) :

Maladies infectieuses et immunitaires
  • Leucocytes
  • Maladies auto-immunes
Nutrition et métabolisme
  • Diabète
  • Maladie de Crohn
  • Maladies métaboliques
  • Désordres métaboliques
Vieillissement
  • Maladies chroniques chez les personnes âgées
  • Âge et facteurs de risques

Projets de recherche

  • FcgRI as a potential therapeutic target in inflammatory arthritis - La société d'arthrite, chercheur principal - 2022-01-01 au 2025-03-31
  • Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
  • Surveillance des réponses immunitaires au vaccin contre la COVID-19 chez les personnes vivant avec le VIH-1 - Instituts de recherche en santé du Canada - Subvention de fonctionnement:Nouveaux besoins prioritaires en recherche sur la COVID-19, co-chercheur - 2021-12-01 au 2022-11-30
  • Informer de la sécurité des stratégies vaccinales visant la protéine Spike du SRAS-CoV-2 - Fondation du Centre hospitalier de l'Université de Montréal (CHUM), Ministère de l'Économie et de l'Innovation, Fondation du CHU de Québec - Programme de soutien aux organismes de recherche et d’innovation (PSO) - Recherche-innovation - Volet 2a, chercheur principal - 2020-06-01 au 2021-06-30
  • Profil moléculaire sanguin de patientes souffrant de lupus - CHU de Québec – Université Laval – CHUL - Développement de la recherche (RFI), co-chercheur - 2019-04-01 au 2021-03-31
  • Defective prostaglandin biosynthesis pathways and abnormal crosstalk at the endometrial/peritoneal interface: role in the pathophysiology of endometriosis. - Instituts de recherche en santé du Canada - Subvention de fonctionnement, chercheur principal - 2012-10-01 au 2021-03-31
  • Plateforme de criblage préclinique pour des composés antiviraux à large spectre - Fonds de recherche du Québec - Santé - Initiatives dans le cadre de la pandémie COVID-19, Université de Montréal, co-chercheur - 2020-04-01 au 2021-03-31
  • Understanding the pathogenesis of COVID-19 - Instituts de recherche en santé du Canada, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Subvention de fonctionnement : Possibilité de financement canadienne pour une intervention de recherche rapide contre la maladie à coronavirus 2019 (COVID-19), co-chercheur - 2020-03-01 au 2021-02-28

Publications

  • Platelets release mitochondrial antigens in systemic lupus erythematosus., , Science translational medicine, 2021, 10.1126/scitranslmed.aav5928
  • IgG-aggregates rapidly up-regulate FcgRI expression at the surface of human neutrophils in a FcgRII-dependent fashion: A crucial role for FcgRI in the generation of reactive oxygen species, Sandrine Huot, Cynthia Laflamme, Paul R. Fortin, Eric Boilard, Marc Pouliot, 2020, 10.1101/2020.03.04.975094
  • Age-related decline of the acute local inflammation response: a mitigating role for the adenosine A2A receptor., , Aging, 2017, 10.18632/aging.101303
  • Early tyrosine phosphorylation events following adenosine A2A receptor in human neutrophils: identification of regulated pathways., , Journal of leukocyte biology, 2017, 10.1189/jlb.2vma1216-517r
  • Augmented Angiogenic Factors Expression via FP Signaling Pathways in Peritoneal Endometriosis., , The Journal of clinical endocrinology and metabolism, 2016, 10.1210/jc.2016-1569
  • Promotion of angiogenesis and proliferation cytokines patterns in peritoneal fluid from women with endometriosis, Rakhila, H., Al-Akoum, M., Bergeron, M.-E., Leboeuf, M., Lemyre, M., Akoum, A., Pouliot, M., Journal of Reproductive Immunology, 2016, 10.1016/j.jri.2016.01.005
  • Abnormal Expression of Prostaglandins E2 and F2 α Receptors and Transporters in Patients with Endometriosis, Rakhila, H., Bourcier, N., Akoum, A., Pouliot, M., BioMed Research International, 2015, 10.1155/2015/808146
  • Erratum:Platelet microparticles are internalized in neutrophilsvia the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA (Proceedings of the National Academy of Sciences of the United States of America (2015) 112 (E3564-E3573) DOI 10.1073/pnas.1507905112), Duchez, A.-C., Boudreau, L.H., Naika, G.S., Bollinger, J., Belleannée, C., Cloutier, N., Laffont, B., Mendoza-Villarroel, R.E., Lévesque, T., Rollet-Labelle, E., Rousseau, M., Allaeys, I., Tremblay, J.J., Poubelle, P.E., Lambeau, G., Pouliot, M., Provost, P., Soulet, D., Gelb, M.H., Boilard, E., Proceedings of the National Academy of Sciences of the United States of America, 2015, 10.1073/pnas.1522504112
  • Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA, Duchez, A.-C., Boudreau, L.H., Bollinger, J., Belleannée, C., Cloutier, N., Laffont, B., Mendoza-Villarroel, R.E., Lévesque, T., Rollet-Labelle, E., Rousseau, M., Allaeys, I., Tremblay, J.J., Poubelle, P.E., Lambeau, G., Pouliot, M., Provost, P., Soulet, D., Gelb, M.H., Boilard, E., Proceedings of the National Academy of Sciences of the United States of America, 2015, 10.1073/pnas.1507905112
  • Characterization of the Na/HCO3 - cotransport in human neutrophils, Giambelluca, M.S., Ciancio, M.C., Orlowski, A., Gende, O.A., Pouliot, M., Aiello, E.A., Cellular Physiology and Biochemistry, 2014, 10.1159/000358669
  • Evidence of impairment of normal inflammatory reaction by a high-fat diet, Laflamme, C., Bertheau-Mailhot, G., Giambelluca, M.S., Cloutier, N., Boilard, E., Pouliot, M., Genes and Immunity, 2014, 10.1038/gene.2014.8
  • Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase a to promote inflammation, Boudreau, L.H., Duchez, A.-C., Cloutier, N., Soulet, D., Martin, N., Bollinger, J., Paré, A., Rousseau, M., Naika, G.S., Lévesque, T., Laflamme, C., Marcoux, G., Lambeau, G., Farndale, R.W., Pouliot, M., Hamzeh-Cognasse, H., Cognasse, F., Garraud, O., Nigrovic, P.A., Guderley, H., Lacroix, S., Thibault, L., Semple, J.W., Gelb, M.H., Boilard, E., Blood, 2014, 10.1182/blood-2014-05-573543
  • TNF-α expression in neutrophils and its regulation by glycogen synthase kinase-3: A potentiating role for lithium, Giambelluca, M.S., Bertheau-Mailhot, G., Laflamme, C., Rollet-Labelle, E., Servant, M.J., Pouliot, M., FASEB Journal, 2014, 10.1096/fj.14-251900
  • Expression and regulation of glycogen synthase kinase 3 in human neutrophils, Giambelluca, M.S., Cloutier, N., Rollet-Labelle, E., Boilard, E., Pouliot, M., International Journal of Biochemistry and Cell Biology, 2013, 10.1016/j.biocel.2013.09.001
  • Oncostatin M decreases interleukin-1 β secretion by human synovial fibroblasts and attenuates an acute inflammatory reaction in vivo, Dumas, A., Lagarde, S., Laflamme, C., Pouliot, M., Journal of Cellular and Molecular Medicine, 2012, 10.1111/j.1582-4934.2011.01412.x
  • Osteoblast retraction induced by adherent neutrophils promotes osteoclast bone resorption: Implication for altered bone remodeling in chronic gout, Allaeys, I., Rusu, D., Picard, S., Pouliot, M., Borgeat, P., Poubelle, P.E., Laboratory Investigation, 2011, 10.1038/labinvest.2011.46
  • Pro-inflammatory type-1 and anti-inflammatory type-2 macrophages differentially modulate cell survival and invasion of human bladder carcinoma T24 cells, Dufresne, M., Dumas, G., Asselin, T., Carrier, C., Pouliot, M., Reyes-Moreno, C., Molecular Immunology, 2011, 10.1016/j.molimm.2011.04.022
  • The pronociceptive effect of proteinase-activated receptor-4 stimulation in rat knee joints is dependent on mast cell activation, Russell, F.A., Zhan, S., Dumas, A., Lagarde, S., Pouliot, M., McDougall, J.J., Pain, 2011, 10.1016/j.pain.2010.10.038
  • Proteinase-activated receptor-2 up-regulation by Fcγ-receptor activation in human neutrophils, St-Onge, M., Lagarde, S., Laflamme, C., Rollet-Labelle, E., Marois, L., Naccache, P.H., Pouliot, M., FASEB Journal, 2010, 10.1096/fj.09-146167
  • Impact of anti-inflammatory agents on the gene expression profile of stimulated human neutrophils: Unraveling endogenous resolution pathways, St-Onge, M., Dumas, A., Michaud, A., Laflamme, C., Dussault, A.-A., Pouliot, M., PLoS ONE, 2009, 10.1371/journal.pone.0004902
  • Neutrophil: Foe or friend? | Le neutrophile: Ennemi ou ami?, Dumas, A., Pouliot, M., Medecine/Sciences, 2009
  • A functional toll-like receptor 8 variant is associated with HIV disease restriction, Oh, D.-Y., Taube, S., Hamouda, O., Kücherer, C., Poggensee, G., Jessen, H., Eckert, J.K., Neumann, K., Storek, A., Pouliot, M., Borgeat, P., Oh, N., Schreier, E., Pruss, A., Hattermann, K., Schumann, R.R., Journal of Infectious Diseases, 2008, 10.1086/590431
  • Nucleobindin co-localizes and associates with cyclooxygenase (COX)-2 in human neutrophils, Leclerc, P., Biarc, J., St.-Onge, M., Gilbert, C., Dussault, A.-A., Laflamme, C., Pouliot, M., PLoS ONE, 2008, 10.1371/journal.pone.0002229
  • Characterization of prostaglandin E2 generation through the cyclooxygenase (COX)-2 pathway in human neutrophils, St-Onge, M., Flamand, N., Biarc, J., Picard, S., Bouchard, L., Dussault, A.-A., Laflamme, C., James, M.J., Caughey, G.E., Cleland, L.G., Borgeat, P., Pouliot, M., Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 2007, 10.1016/j.bbalip.2007.06.002
  • The Toll-like receptor 7/8-ligand resiquimod (R-848) primes human neutrophils for leukotriene B4, prostaglandin E2 and platelet-activating factor biosynthesis, Hattermann, K., Picard, S., Borgeat, M., Leclerc, P., Pouliot, M., Borgeat, P., FASEB Journal, 2007, 10.1096/fj.06-7457com
  • Effects of pyrrophenone, an inhibitor of group IVA phospholipase A 2, on eicosanoid and PAF biosynthesis in human neutrophils, Flamand, N., Picard, S., Lemieux, L., Pouliot, M., Bourgoin, S.G., Borgeat, P., British Journal of Pharmacology, 2006, 10.1038/sj.bjp.0706879
  • Hypoxia induces epithelial amphiregulin gene expression in a CREB-dependent manner, O'Reilly, S.M., Leonard, M.O., Kieran, N., Comerford, K.M., Cummins, E., Pouliot, M., Lee, S.B., Taylor, C.T., American Journal of Physiology - Cell Physiology, 2006, 10.1152/ajpcell.00278.2005
  • Immunomodulatory impact of the A2A adenosine receptor on the profile of chemokines produced by neutrophils, McColl, S.R., St-Onge, M., Dussault, A.-A., Laflamme, C., Bouchard, L., Boulanger, J., Pouliot, M., FASEB Journal, 2006, 10.1096/fj.05-4804fje
  • Rapid and simple comparison of messenger RNA levels using real-time PCR, Dussault, A.-A., Pouliot, M., Biological Procedures Online, 2006, 10.1251/bpo114
  • Potentiation of neutrophil cyclooxygenase-2 by adenosine: An early anti-inflammatory signal, Cadieux, J.-S., Leclerc, P., St-Onge, M., Dussault, A.-A., Laflamme, C., Picard, S., Ledent, C., Borgeat, P., Pouliot, M., Journal of Cell Science, 2005, 10.1242/jcs.01737
  • Crystal-induced neutrophil activation: VIII. Immediate production of prostaglandin E2 mediated by constitutive cyclooxygenase 2 in human neutrophils stimulated by urate crystals, Gilbert, C., Poubelle, P.E., Borgeat, P., Pouliot, M., Naccache, P.H., Arthritis and Rheumatism, 2003, 10.1002/art.10851
  • Human neutrophils as a source of nociceptin: A novel link between pain and inflammation, Fiset, M.-É., Gilbert, C., Poubelle, P.E., Pouliot, M., Biochemistry, 2003, 10.1021/bi0300635
  • Adenosine up-regulates cyclooxygenase-2 in human granulocytes: Impact on the balance of eicosanoid generation, Pouliot, M., Fiset, M.-É., Massé, M., Naccache, P.H., Borgeat, P., Journal of Immunology, 2002
  • Cutting edge: Nociceptin stimulates neutrophil chemotaxis and recruitment: Inhibition by aspirin-triggered-15-epi-lipoxin A4, Serhan, C.N., Fierro, I.M., Chiang, N., Pouliot, M., Journal of Immunology, 2001
  • Lipoxin A4 analogues inhibit leukocyte recruitment to Porphyromonas gingivalis: A role for cyclooxygenase-2 and lipoxins in periodontal disease, Pouliot, M., Clish, C.B., Petasis, N.A., Van Dyke, T.E., Serhan, C.N., Biochemistry, 2000, 10.1021/bi992551b
  • Lipoxin (LX)A4 and aspirin-triggered 15-epi-LXA4 inhibit tumor necrosis factor 1α-initiated neutrophil responses and trafficking: Regulators of a cytokine-chemokine axis, Hachicha, M., Pouliot, M., Petasis, N.A., Serhan, C.N., Journal of Experimental Medicine, 1999, 10.1084/jem.189.12.1923
  • Lipoxin A4 and aspirin-triggered 15-epi-LXA4 inhibit tumor necrosis factor-α-initiated neutrophil responses and trafficking: Novel regulators of a cytokine-chemokine axis relevant to periodontal diseases, Pouliot, M., Serhan, C.N., Journal of Periodontal Research, 1999
  • Expression and activity of prostaglandin endoperoxide synthase-2 in agonist-activated human neutrophils, Pouliot, M., Gilbert, C., Borgeat, P., Poubelle, P.E., Bourgoin, S., Créminon, C., Maclouf, J., McColl, S.R., Naccache, P.H., FASEB Journal, 1998
  • Monosodium urate microcrystals induce cyclooxygenase-2 in human monocytes, Pouliot, M., James, M.J., McColl, S.R., Naccache, P.H., Cleland, L.G., Blood, 1998
  • Inhibition of Prostaglandin Endoperoxide Synthase-2 Expression in Stimulated Human Monocytes by Inhibitors of p38 Mitogen-Activated Protein Kinase, Pouliot, M., Baillargeon, J., Lee, J.C., Cleland, L.G., James, M.J., Journal of Immunology, 1997
  • Regulation of Tumor Necrosis Factor-α and IL-1β Synthesis by Thromboxane A2 in Nonadherent Human Monocytes, Caughey, G.E., Pouliot, M., Cleland, L.G., James, M.J., Journal of Immunology, 1997
  • Colocalization of cytosolic phospholipase A2, 5-lipoxygenase, and 5-lipoxygenase-activating protein at the nuclear membrane of A23187-stimulated human neutrophils, Pouliot, M., Mcdonald, P.P., Krump, E., Mancini, J.A., Mccoll, S.R., Weech, P.K., Borgeat, P., European Journal of Biochemistry, 1996
  • Leukotriene synthesis in calcium-depleted human neutrophils: Arachidonic acid release correlates with calcium influx, Krump, E., Pouliot, M., Naccache, P.H., Borgeat, P., Biochemical Journal, 1995
  • Granulocyte-macrophage colony-stimulating factor enhances 5-lipoxygenase levels in human polymorphonuclear leukocytes, Pouliot, M., McDonald, P.P., Khamzina, L., Borgeat, P., McColl, S.R., Journal of Immunology, 1994
  • Granulocyte/macrophage colony-stimulating factor stimulates the expression of the 5-lipoxygenase-activating protein (FLAP) in human neutrophils, Pouliot, M., McDonald, P.P., Borgeat, P., McColl, S.R., Journal of Experimental Medicine, 1994
  • Induction by Chemokines of Lipid Mediator Synthesis in Granulocyte-Macrophage Colony-Stimulating Factor-Treated Human Neutrophils, McDonald, P.P., Pouliot, M., Borgeat, P., McColl, S.R., Journal of Immunology, 1993
  • Enhancement by GM-CSF of agonist-induced 5-lipoxygenase activation in human neutrophils involves protein synthesis and gene transcription, McDonald, P.P., Pouliot, M., Borgeat, P., Journal of Lipid Mediators, 1992

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Geneviève Bertheau Mailhot - Doctorat - En cours
  • Annie Pelletier - Maîtrise avec mémoire - En cours
  • Lisa Auclert - Doctorat - En cours
  • Sandrine Huot - Doctorat - En cours
  • Halima Rakhila - Doctorat - 2016/01

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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