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Marc Ouellette

Professeur titulaire

Directeur(trice), Centre de recherche en infectiologie

Marc Ouellette
marc.ouellette@fmed.ulaval.ca
Centre de recherche en infectiologie
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Thématiques de recherche de la Faculté de médecine

  • Bioinformatique / données massives (big data)
  • Immunologie-infectiologie

Projets de recherche en cours

  • Genomics of antimicrobial resistance and drug/target discovery - Instituts de recherche en santé du Canada - Subventions Fondation, chercheur principal - 2019-07-01 au 2027-06-30
  • AviBiocin II Les bactériocines comme solution antimicrobienne innovante pour la réduction de l’usage des antibiotiques dans le secteur aviaire: de la preuve de concept à la commercialisation - Centre de recherches pour le développement international - Appel de propositions : Élaborer des solutions vétérinaires innovatrices pour la résistance aux antimicrobiens – phase 2, co-chercheur - 2024-01-01 au 2027-01-31
  • Appui du VRRCI aux activités entourant le 50e anniversaire du CRI - Université Laval - Fonds internes - BDR - Contributions, chercheur principal - 2024-09-01 au 2025-08-31
  • Caractérisation d'un traitement anti-buée en milieu médical - MITACS Inc. - Accélération Québec (MITACS et gouvernement provincial), chercheur principal - 2023-05-15 au 2025-07-14

Financements des 2 dernières années

  • Nouveaux dérivés de triterpènes biosourcés pour le contrôle de parasites protozoaires - Matrix Innovation, Fondation du CHU de Québec, Ministère de l'Économie et de l'Innovation et de l'énergie - Projets de maturation technologique PSO – volet 2d, co-chercheur - 2023-07-10 au 2024-07-10
  • Chaire de recherche du Canada sur la résistance aux antiantimicrobiens - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2017-04-01 au 2024-03-31
  • Les bactériocines : une alternative naturelle fort prometteuse pour le remplacement des antibiotiques en production avicole. - Centre de recherches pour le développement international - Appel de propositions : Élaborer des solutions vétérinaires innovatrices pour la résistance aux antimicrobiens, co-chercheur - 2019-04-01 au 2022-03-31

Publications

  • Parasite susceptibility to amphotericin B in failures of treatment for visceral leishmaniasis in patients coinfected with HIV type 1 and Leishmania infantum, Ouellette, M., Bastien, P., Leprohon, P., Plourde, M., Bourgeois, N., Lachaud, L., Clin Infect Dis, 2009, 10.1086/595710
  • Intrachromosomal amplification, locus deletion and point mutation in the aquaglyceroporin AQP1 gene in antimony resistant Leishmania (Viannia) guyanensis, Ouellette, M., Frézard, F., Reis, P., Leprohon, P., Laffitte, M. C., Monte-Neto, R., PLoS Negl Trop Dis, 2015, 10.1371/journal.pntd.0003476
  • Modulation of gene expression in human macrophages treated with the anti-leishmania pentavalent antimonial drug sodium stibogluconate, Ouellette, M., Légaré, D., Tremblay, M. J., Bergeron, M., Gourbal, B., Roy, G., Messier, N., Imbeault, M., El Fadili, K., Antimicrob Agents Chemother, 2008, 10.1128/AAC.01183-07
  • A combined proteomic and transcriptomic approach to the study of stage differentiation in Leishmania infantum, Papadopoulou, B., Ouellette, M., Boilard, N., Madore, E., Müller, M., Drummelsmith, J., McNicoll, F., Proteomics, 2006, 10.1002/pmic.200500853
  • Development of a PCR assay for rapid detection of enterococci, Bergeron, M. G., Ouellette, M., Roy, P. H., Ménard, C., Martineau, F., Picard, F. J., Ke, D., J Clin Microbiol, 1999
  • Combined gene deletion of dihydrofolate reductase-thymidylate synthase and pteridine reductase in Leishmania infantum, Marc Ouellette, Philippe Leprohon, Arijit Bhattacharya, PLOS Neglected Tropical Diseases, 2021, 10.1371/journal.pntd.0009377
  • Binding of Mycoplasma arthritidis-derived mitogen to human MHC class II molecules via its N terminus is modulated by invariant chain expression and its C terminus is required for T cell activation, Mourad, W., Ouellette, M., Etongué-Mayer, P., Langlois, M. A., Eur J Immunol, 2000, 10.1002/1521-4141(200006)30:6<1748::AID-IMMU1748>3.0.CO;2-J
  • An ATP-dependent As(III)-glutathione transport system in membrane vesicles of Leishmania tarentolae, Rosen, B. P., Papadopoulou, B., Lightbody, J., Ouellette, M., Dey, S., Proc Natl Acad Sci U S A, 1996
  • Whole genome analysis of linezolid resistance in Streptococcus pneumoniae reveals resistance and compensatory mutations, Ouellette, M., Légaré, D., Leprohon, P., Feng, J., Billal, D. S., BMC Genomics, 2011, 10.1186/1471-2164-12-512
  • Phylogeny of the Enterobacteriaceae based on genes encoding elongation factor Tu and F-ATPase beta-subunit, Bergeron, M. G., Roy, P. H., Ouellette, M., Picard, F. J., Boudreau, D. K., Martel, E. A., Bélanger, S. D., Paquette, N., Boissinot, M., Paradis, S., Int J Syst Evol Microbiol, 2005, 10.1099/ijs.0.63539-0
  • Elevated levels of polyamines and trypanothione resulting from overexpression of the ornithine decarboxylase gene in arsenite-resistant Leishmania, Ouellette, M., Poulin, R., Rosen, B. P., Mukhopadhyay, R., Pilote, S., Guimond, C., Haimeur, A., Mol Microbiol, 1999
  • Interactions between BRCA2 and RAD51 for promoting homologous recombination in Leishmania infantum, Masson, J. Y., Ouellette, M., Coulombe, Y., Plourde, M., Roy, G., Paquet, E., Buisson, R., Ubeda, J. M., Mukherjee, A., Genois, M. M., Nucleic Acids Res, 2012, 10.1093/nar/gks306
  • Co-amplification of the gamma-glutamylcysteine synthetase gene gsh1 and of the ABC transporter gene pgpA in arsenite-resistant Leishmania tarentolae, Ouellette, M., Rosen, B. P., Mukhopadhyay, R., Haimeur, A., Grondin, K., EMBO J, 1997, 10.1093/emboj/16.11.3057
  • Recombinant Leishmania major secreting biologically active granulocyte-macrophage colony-stimulating factor survives poorly in macrophages in vitro and delays disease development in mice, Papadopoulou, B., Olivier, M., Ouellette, M., Matte, C., Roy, G., Muyombwe, A., Dumas, C., Infect Immun, 2003
  • Development of conventional and real-time PCR assays for the rapid detection of group B streptococci, Bergeron, M. G., Roy, P. H., Ouellette, M., Boissinot, M., Picard, F. J., Ménard, C., Ke, D., Clin Chem, 2000
  • Plasticity of the Leishmania genome leading to gene copy number variations and drug resistance, Ouellette, M., Papadopoulou, B., Leprohon, P., Laffitte, M. N., F1000Res, 2016, 10.12688/f1000research.9218.1
  • Characterization of the folylpolyglutamate synthetase gene and polyglutamylation of folates in the protozoan parasite Leishmania, Ouellette, M., Kündig, C., El Fadili, A., Mol Biochem Parasitol, 2002
  • Formation of extrachromosomal circular amplicons with direct or inverted duplications in drug-resistant Leishmania tarentolae, Ouellette, M., Roy, G., Grondin, K., Mol Cell Biol, 1996
  • Down regulation of KMP-11 in Leishmania infantum axenic antimony resistant amastigotes as revealed by a proteomic screen, Ouellette, M., Jardim, A., Roy, G., Drummelsmith, J., El Fadili, K., Exp Parasitol, 2009, 10.1016/j.exppara.2009.05.013
  • Role of the ABC transporter MRPA (PGPA) in antimony resistance in Leishmania infantum axenic and intracellular amastigotes, Ouellette, M., Légaré, D., Papadopoulou, B., Saravia, N. G., Trudel, N., Guimond, C., Roy, G., Leprohon, P., Messier, N., El Fadili, K., Antimicrob Agents Chemother, 2005, 10.1128/AAC.49.5.1988-1993.2005
  • Changes in folate and pterin metabolism after disruption of the Leishmania H locus short chain dehydrogenase gene, Ouellette, M., Leblanc, E., Mourad, W., Roy, G., Papadopoulou, B., J Biol Chem, 1994
  • Frequent amplification of a short chain dehydrogenase gene as part of circular and linear amplicons in methotrexate resistant Leishmania, Ouellette, M., Roy, G., Papadopoulou, B., Nucleic Acids Res, 1993
  • Generation of Leishmania hybrids by whole genomic DNA transformation, Ouellette, M., Leprohon, P., Coelho, A. C., PLoS Negl Trop Dis, 2012, 10.1371/journal.pntd.0001817
  • Untargeted metabolomic analysis of miltefosine action in Leishmania infantum reveals changes to the internal lipid metabolism, Ouellette, M., Smith, T. K., Burgess, K., Rivas, L., Weidt, S., Vincent, I. M., Int J Parasitol Drugs Drug Resist, 2014, 10.1016/j.ijpddr.2013.11.002
  • Functional analysis and complex gene rearrangements of the folate/biopterin transporter (FBT) gene family in the protozoan parasite Leishmania, Ouellette, M., Légaré, D., Girard, I., Ouameur, A. A., Mol Biochem Parasitol, 2008, 10.1016/j.molbiopara.2008.08.007
  • Biochemical and molecular mechanisms of drug resistance in parasites, Ouellette, M., Trop Med Int Health, 2001
  • Use of oral miltefosine for cutaneous leishmaniasis in Canadian soldiers returning from Afghanistan, Rubinstein, E., Ouellette, M., Plourde, M., Wiseman, M. C., Larios, O. E., Keynan, Y., Can J Infect Dis Med Microbiol, 2008
  • Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania, Rosen, B. P., Ouellette, M., Lightbody, J., Gage, D., Xu, N., Dey, S., Mukhopadhyay, R., Proc Natl Acad Sci U S A, 1996
  • DNA repair pathways in trypanosomatids: from DNA repair to drug resistance, Masson, J. Y., Ouellette, M., Rodrigue, A., Maity, R., Laffitte, M. C., Paquet, E. R., Genois, M. M., Microbiol Mol Biol Rev, 2014, 10.1128/MMBR.00045-13
  • Real-time PCR assay for detection of fluoroquinolone resistance associated with grlA mutations in Staphylococcus aureus, Bergeron, M. G., Ouellette, M., Roy, P. H., Picard, F. J., Fortin, V., Huletsky, A., Lapierre, P., J Clin Microbiol, 2003
  • Differences in antibiotic-induced oxidative stress responses between laboratory and clinical isolates of Streptococcus pneumoniae, Ouellette, M., Leprohon, P., Bergeron, M. G., Lupien, A., Dridi, B., Antimicrob Agents Chemother, 2015, 10.1128/AAC.00316-15
  • Decreased glutamate transport in acivicin resistant Leishmania tarentolae, Marc Ouellette, Philippe Leprohon, Arijit Bhattacharya, Gaétan Roy, PLOS Neglected Tropical Diseases, 2021, 10.1371/journal.pntd.0010046
  • Drug resistance and P-glycoprotein gene amplification in the protozoan parasite Leishmania, Borst, P., Ouellette, M., Res Microbiol, 1991
  • Multiple mutations in heterogeneous miltefosine-resistant Leishmania major population as determined by whole genome sequencing, Ouellette, M., Corbeil, J., Leprohon, P., Mukherjee, A., Boisvert, S., Coelho, A. C., PLoS Negl Trop Dis, 2012, 10.1371/journal.pntd.0001512
  • Isolation and molecular characterization of beta-lactamase-producing Haemophilus parainfluenzae from the genital tract, Bergeron, M. G., Roy, P. H., Ouellette, M., Gosselin, P., Martel, A. Y., Antimicrob Agents Chemother, 1987
  • Whole genome sequencing of penicillin-resistant Streptococcus pneumoniae reveals mutations in penicillin-binding proteins and in a putative iron permease, Ouellette, M., Légaré, D., Leprohon, P., Fani, F., Genome Biol, 2011, 10.1186/gb-2011-12-11-r115
  • Correlation between microarray DNA hybridization efficiency and the position of short capture probe on the target nucleic acid, Bergeron, M. G., Ouellette, M., Huletsky, A., Picard, F. J., Boissinot, M., Bissonnette, L., Boissinot, K., Raymond, F. R., Liu-Ying, T., Peytavi, R., Biotechniques, 2005
  • Microbial multidrug-resistance ABC transporters, Papadopoulou, B., Légaré, D., Ouellette, M., Trends Microbiol, 1994
  • Intracellular localization of the ABCC proteins of Leishmania and their role in resistance to antimonials, Ouellette, M., Légaré, D., Leprohon, P., Antimicrob Agents Chemother, 2009, 10.1128/AAC.01474-08
  • New real-time PCR assay for rapid detection of methicillin-resistant Staphylococcus aureus directly from specimens containing a mixture of staphylococci, Bergeron, M. G., Roy, P. H., Ouellette, M., van Belkum, A., Picard, F. J., Bastien, M., Truchon, K., Gagnon, F., Bernier, M., Vaillancourt, M., Gagnon, M., Rossbach, V., Giroux, R., Huletsky, A., J Clin Microbiol, 2004
  • Amplification of ABC transporter gene pgpA and of other heavy metal resistance genes in Leishmania tarentolae and their study by gene transfection and gene disruption, Papadopoulou, B., Légaré, D., Grondin, K., Haimeur, A., Ouellette, M., Methods Enzymol, 1998
  • Direct and inverted DNA repeats associated with P-glycoprotein gene amplification in drug resistant Leishmania, Borst, P., Fase-Fowler, F., Wüst, D., Hettema, E., Ouellette, M., EMBO J, 1991
  • Spread of SHV-1 beta-lactamase in Escherichia coli isolated from fecal samples in Africa, Cluzel, R., Joly, B., Sirot, D., Ouellette, M., Shaokat, S., Antimicrob Agents Chemother, 1987
  • Species-specific and ubiquitous-DNA-based assays for rapid identification of Staphylococcus aureus, Bergeron, M. G., Ouellette, M., Roy, P. H., Picard, F. J., Martineau, F., J Clin Microbiol, 1998
  • Coordinated gene expression by post-transcriptional regulons in African trypanosomes, Papadopoulou, B., Ouellette, M., J Biol, 2009, 10.1186/jbiol203
  • The amplified H circle of methotrexate-resistant leishmania tarentolae contains a novel P-glycoprotein gene, Borst, P., Fase-Fowler, F., Ouellette, M., EMBO J, 1990
  • The role of reduced pterins in resistance to reactive oxygen and nitrogen intermediates in the protozoan parasite Leishmania, Ouellette, M., Leblanc, E., Moreira, W., Free Radic Biol Med, 2009, 10.1016/j.freeradbiomed.2008.10.034
  • Resistance of Leishmania donovani to sodium stibogluconate is related to the expression of host and parasite gamma-glutamylcysteine synthetase, Mullen, A. B., Roberts, C. W., Ouellette, M., Légaré, D., Henriquez, F. L., Hutchison, S., Carter, K. C., Antimicrob Agents Chemother, 2006, 10.1128/AAC.50.1.88-95.2006
  • Acquisition by a Campylobacter-like strain of aphA-1, a kanamycin resistance determinant from members of the family Enterobacteriaceae, Courvalin, P., Lambert, T., Gerbaud, G., Ouellette, M., Antimicrob Agents Chemother, 1987
  • Cos-Seq for high-throughput identification of drug target and resistance mechanisms in the protozoan parasite Leishmania, Ouellette, M., Leprohon, P., Papadopoulou, B., Fernández-Prada, C., Gazanion, É, Proc Natl Acad Sci U S A, 2016, 10.1073/pnas.1520693113
  • Mitochondrial Proteomics of Antimony and Miltefosine Resistant Leishmania infantum, Ouellette, M., Légaré, D., Racine, G., Vincent, I. M., Proteomes, 2015, 10.3390/proteomes3040328
  • Genetic polymorphisms and drug susceptibility in four isolates of Leishmania tropica obtained from Canadian soldiers returning from Afghanistan, Ouellette, M., Rubinstein, E., Roy, G., Ruest, A., Ndao, M., Larios, O. E., Keynan, Y., Coelho, A., Plourde, M., PLoS Negl Trop Dis, 2012, 10.1371/journal.pntd.0001463
  • Proteomic and transcriptomic analysis of linezolid resistance in Streptococcus pneumoniae, Ouellette, M., Leprohon, P., Légaré, D., Winstall, E., Racine, G., Lupien, A., Billal, D. S., Feng, J., J Proteome Res, 2011, 10.1021/pr200221s
  • Gene amplification and point mutations in pyrimidine metabolic genes in 5-fluorouracil resistant Leishmania infantum, Ouellette, M., Corbeil, J., Légaré, D., Leprohon, P., Raymond, F., Ritt, J. F., PLoS Negl Trop Dis, 2013, 10.1371/journal.pntd.0002564
  • P-glycoprotein overexpression in methotrexate-resistant Leishmania tropica, Castanys, S., Ouellette, M., Légaré, D., Amador, M. V., Chiquero, M. J., Gamarro, F., Biochem Pharmacol, 1994
  • Nondegradable Antimicrobial Silver-Based Perovskite, Houshang Alamdari, Hossein Salimnia, Marc Ouellette, Fereshteh Fani, Cyrus Talebpour, ACS Sustainable Chemistry & Engineering, 2022, 10.1021/acssuschemeng.1c08181
  • Analysis of membrane-enriched and high molecular weight proteins in Leishmania infantum promastigotes and axenic amastigotes, Ouellette, M., Papadopoulou, B., Leprohon, P., Ouameur, A. A., Racine, G., Brotherton, M. C., J Proteome Res, 2012, 10.1021/pr201248h
  • Role of the ABC transporter PRP1 (ABCC7) in pentamidine resistance in Leishmania amastigotes, Cotrim, P. C., Ouellette, M., Messier, N., Coelho, A. C., Antimicrob Agents Chemother, 2007, 10.1128/AAC.00404-07
  • Genomic analyses of DNA transformation and penicillin resistance in Streptococcus pneumoniae clinical isolates, Ouellette, M., Bergeron, M. G., Zhanel, G. G., Leprohon, P., Fani, F., Antimicrob Agents Chemother, 2014, 10.1128/AAC.01311-13
  • Genome annotation and intraviral interactome for the Streptococcus pneumoniae virulent phage Dp-1, Moineau, S., Uetz, P., Titz, B., García, E., Moeck, G., Dehbi, M., Liu, J., Ouellette, M., Häuser, R., Sabri, M., J Bacteriol, 2011, 10.1128/JB.01117-10
  • Genome-wide gene expression profiling analysis of Leishmania major and Leishmania infantum developmental stages reveals substantial differences between the two species, Papadopoulou, B., Ouellette, M., Corbeil, J., Rigault, P., Boisvert, S., Messier, N., Smith, M., Ubeda, J. M., Raymond, F., Rochette, A., BMC Genomics, 2008, 10.1186/1471-2164-9-255
  • Telomeric gene deletion and intrachromosomal amplification in antimony-resistant Leishmania, Ouellette, M., Corbeil, J., Mukhopadhyay, R., Raymond, F., Coelho, A. C., Monte-Neto, R. L., Boisvert, S., Mukherjee, A., Mol Microbiol, 2013, 10.1111/mmi.12178
  • Point mutations in functionally diverse genes are associated with increased natural DNA transformation in multidrug resistant Streptococcus pneumoniae, Marc Ouellette, Philippe Leprohon, Jie Feng, Chantal Godin, Hélène Gingras, Nguyen Phuong Pham, Flora Peillard-Fiorente, Nucleic Acids Research, 2025, 10.1093/nar/gkae1140
  • Species-specific and ubiquitous DNA-based assays for rapid identification of Staphylococcus epidermidis, Bergeron, M. G., Ouellette, M., Roy, P. H., Picard, F. J., Martineau, F., J Clin Microbiol, 1996
  • The gamma-glutamylcysteine synthetase gene of Leishmania is essential and involved in response to oxidants, Ouellette, M., Guimond, C., Roy, G., Mukherjee, A., Mol Microbiol, 2009, 10.1111/j.1365-2958.2009.06907.x
  • Genome sequencing of linezolid-resistant Streptococcus pneumoniae mutants reveals novel mechanisms of resistance, Ouellette, M., Légaré, D., Dewar, K., Wasserscheid, J., Gingras, H., Lupien, A., Feng, J., Genome Res, 2009, 10.1101/gr.089342.108
  • The initial state of the human gut microbiome determines its reshaping by antibiotics, Corbeil, J., Bergeron, M. G., Ouellette, M., Roy, P. H., Huletsky, A., Boissinot, M., Trottier, S., Domingo, M. C., Chabot, I., Simard, J. L., Boudreau, D. K., Frenette, J., Bérubé, È, Giroux, R., Plante, P. L., Leprohon, P., Dridi, B., Gingras, H., Iqbal, N., Déraspe, M., Ouameur, A. A., Raymond, F., ISME J, 2016, 10.1038/ismej.2015.148
  • Drug uptake and modulation of drug resistance in Leishmania by an aquaglyceroporin, Mukhopadhyay, R., Rosen, B. P., Ouellette, M., Sundar, S., Legare, D., Bhattacharjee, H., Sonuc, N., Gourbal, B., J Biol Chem, 2004, 10.1074/jbc.M403959200
  • Selective killing of Leishmania amastigotes expressing a thymidine kinase suicide gene, Papadopoulou, B., Ouellette, M., Olivier, M., Muyombwe, A., Exp Parasitol, 1997, 10.1006/expr.1996.4115
  • Delving in folate metabolism in the parasite Leishmania major through a chemogenomic screen and methotrexate selection, Marc Ouellette, Philippe Leprohon, Sophia Bigot, PLOS Neglected Tropical Diseases, 2023, 10.1371/journal.pntd.0011458
  • Live nonpathogenic parasitic vector as a candidate vaccine against visceral leishmaniasis, Papadopoulou, B., Ouellette, M., Tremblay, M. J., Breton, M., Infect Immun, 2005, 10.1128/IAI.73.10.6372-6382.2005
  • On Lactococcus lactis UL719 competitivity and nisin (Nisaplin(®)) capacity to inhibit Clostridium difficile in a model of human colon, Fliss, I., Ouellette, M., Hammami, R., Fernandez, B., Le Lay, C., Front Microbiol, 2015, 10.3389/fmicb.2015.01020
  • HIV-1 replication is stimulated by sodium stibogluconate, the therapeutic mainstay in the treatment of leishmaniasis, Tremblay, M. J., Ouellette, M., Zhao, C., Barat, C., J Infect Dis, 2007, 10.1086/510398
  • Exoproteome dynamics in Leishmania infantum, Ouellette, M., Cordeiro-da-Silva, A., Silvestre, R., Racine, G., Santarém, N., J Proteomics, 2013, 10.1016/j.jprot.2013.03.012
  • Evidence for horizontal gene transfer in evolution of elongation factor Tu in enterococci, Bergeron, M. G., Roy, P. H., Ouellette, M., Frenette, J., Picard, F. J., Huletsky, A., Boissinot, M., Ke, D., J Bacteriol, 2000
  • Gene amplification in Leishmania tarentolae selected for resistance to sodium stibogluconate, Ouellette, M., Haimeur, A., Antimicrob Agents Chemother, 1998
  • Quantitative proteomic analysis of amphotericin B resistance in Leishmania infantum, Ouellette, M., Droit, A., Poirier, G. G., Légaré, D., Bourassa, S., Brotherton, M. C., Int J Parasitol Drugs Drug Resist, 2014, 10.1016/j.ijpddr.2014.05.002
  • Exploring the genetic basis of natural resistance to microcins, Ismaïl Fliss, Séverine Zirah, Marc Ouellette, Sylvie Rebuffat, Laila Ben Said, Nguyen Phuong Pham, Soufiane Telhig, Microbial Genomics, 2024, 10.1099/mgen.0.001156
  • Glucantime-resistant Leishmania tropica isolated from Iranian patients with cutaneous leishmaniasis are sensitive to alternative antileishmania drugs, Mohebali, M., Ouellette, M., Roy, G., Meamar, A. R., Khamesipour, A., Boucher, P., Hadighi, R., Parasitol Res, 2007, 10.1007/s00436-007-0638-0
  • A novel antifolate resistance gene on the amplified H circle of Leishmania, Ouellette, M., Roy, G., Papadopoulou, B., EMBO J, 1992
  • ABC transporters involved in drug resistance in human parasites, Ouellette, M., Légaré, D., Leprohon, P., Essays Biochem, 2011, 10.1042/bse0500121
  • Reduced infectivity of a Leishmania donovani biopterin transporter genetic mutant and its use as an attenuated strain for vaccination, Ouellette, M., Olivier, M., Singh, A. K., Fillion, I., Dumas, C., Kündig, C., Breton, M., Roy, G., Papadopoulou, B., Infect Immun, 2002
  • Increased transport of pteridines compensates for mutations in the high affinity folate transporter and contributes to methotrexate resistance in the protozoan parasite Leishmania tarentolae, Ouellette, M., Papadopoulou, B., Légaré, D., Haimeur, A., Kündig, C., EMBO J, 1999, 10.1093/emboj/18.9.2342
  • Antifolate resistance mechanisms from bacteria to cancer cells with emphasis on parasites, Papadopoulou, B., Kündig, C., Leblanc, E., Ouellette, M., Adv Exp Med Biol, 1998
  • Oligonucleotide probes (TEM-1, OXA-1) versus isoelectric focusing in beta-lactamase characterization of 114 resistant strains, Roy, P. H., Philippon, A. M., Paul, G. C., Ouellette, M., Antimicrob Agents Chemother, 1988
  • Unresponsiveness to Glucantime treatment in Iranian cutaneous leishmaniasis due to drug-resistant Leishmania tropica parasites, Ouellette, M., Khamesipour, A., Hajjaran, H., Boucher, P., Mohebali, M., Hadighi, R., PLoS Med, 2006, 10.1371/journal.pmed.0030162
  • The promoter for a variant surface glycoprotein gene expression site in Trypanosoma brucei, Borst, P., Clayton, C. E., Bommer, A. M., Kieft, R., ten Asbroek, A. L., Ouellette, M., Zomerdijk, J. C., EMBO J, 1990
  • Adaptation of Leishmania cells to in vitro culture results in a more efficient reduction and transport of biopterin, Ouellette, M., Papadopoulou, B., Olivier, M., Kündig, C., Roy, G., Exp Parasitol, 2001, 10.1006/expr.2001.4595
  • Pterin transport and metabolism in Leishmania and related trypanosomatid parasites, Roy, G., Richard, D., Kündig, C., El-Fadili, A., Drummelsmith, J., Ouellette, M., Int J Parasitol, 2002
  • Growth phase regulation of the main folate transporter of Leishmania infantum and its role in methotrexate resistance, Ouellette, M., Drummelsmith, J., Leprohon, P., Richard, D., J Biol Chem, 2004, 10.1074/jbc.M409264200
  • Characterization of a plasmid isolated from Branhamella catarrhalis and detection of plasmid sequences within the genome of a B. catarrhalis strain, Roy, P. H., Bergeron, M. G., Ouellette, M., Beaulieu, D., Plasmid, 1988
  • Microfluidic device for rapid (<15 min) automated microarray hybridization, Bergeron, M. G., Ouellette, M., Bissonnette, L., Boissinot, M., Boissinot, K., Madou, M., Zoval, J., Jia, G., Picard, F. J., Gagné, D., Raymond, F. R., Peytavi, R., Clin Chem, 2005, 10.1373/clinchem.2005.052845
  • Multiple mutations and increased RNA expression in tetracycline-resistant Streptococcus pneumoniae as determined by genome-wide DNA and mRNA sequencing, Ouellette, M., Leprohon, P., Bergeron, M. G., Gingras, H., Lupien, A., J Antimicrob Chemother, 2015, 10.1093/jac/dkv060
  • Prefractionation by digitonin extraction increases representation of the cytosolic and intracellular proteome of Leishmania infantum, Ouellette, M., Papadopoulou, B., Foucher, A. L., J Proteome Res, 2006, 10.1021/pr060081j
  • Antimony uptake systems in the protozoan parasite Leishmania and accumulation differences in antimony-resistant parasites, Ouellette, M., Saravia, N. G., Wang, X. Y., Messier, N., Roy, G., Wang, J., Brochu, C., Antimicrob Agents Chemother, 2003
  • Leishmaniasis: drugs in the clinic, resistance and new developments, Papadopoulou, B., Drummelsmith, J., Ouellette, M., Drug Resist Updat, 2004, 10.1016/j.drup.2004.07.002
  • Efflux systems and increased trypanothione levels in arsenite-resistant Leishmania, Ouellette, M., Rosen, B. P., Brochu, C., Grondin, K., Dey, S., Haimeur, A., Mukhopadhyay, R., Roy, G., Papadopoulou, B., Légaré, D., Exp Parasitol, 1997, 10.1006/expr.1997.4222
  • Control of surface antigen genes in African trypanosomes, Zomerdijk, J. C., ten Asbroek, A. L., Ouellette, M., Lutgerink, J., Gommers-Ampt, J. H., Borst, P., Biochem Soc Trans, 1990
  • Role of the locus and of the resistance gene on gene amplification frequency in methotrexate resistant Leishmania tarentolae, Ouellette, M., Papadopoulou, B., Leblanc, E., Kündig, C., Nucleic Acids Res, 1999
  • [Studies on the parasite Leishmania in the post-genomic era], Papadopoulou, B., Sato, S., Olivier, M., Ouellette, M., Med Sci (Paris), 2003, 10.1051/medsci/20031910900
  • Effect of polyglutamylation of methotrexate on its accumulation and the development of resistance in the protozoan parasite Leishmania, Ouellette, M., Kündig, C., Richard, D., El-Fadili, A., Biochem Pharmacol, 2003
  • Induced tigecycline resistance in Streptococcus pneumoniae mutants reveals mutations in ribosomal proteins and rRNA, Ouellette, M., Leprohon, P., Gingras, H., Lupien, A., J Antimicrob Chemother, 2015, 10.1093/jac/dkv211
  • Divergence among genes encoding the elongation factor Tu of Yersinia Species, Bergeron, M. G., Ouellette, M., Roy, P. H., Bryden, L., Mulvey, M. R., Bader, D. E., Chain, P. S., Parham, N. J., Martel, E. A., Picard, F. J., Grondin, M., Boudreau, D. K., Boissinot, M., Leblanc, E., Isabel, S., J Bacteriol, 2008, 10.1128/JB.01067-08
  • A new type of high affinity folic acid transporter in the protozoan parasite Leishmania and deletion of its gene in methotrexate-resistant cells, Ouellette, M., Kündig, C., Richard, D., J Biol Chem, 2002, 10.1074/jbc.M204796200
  • Use of phylogenetical analysis to predict susceptibility of pathogenic Candida spp. to antifungal drugs, Bergeron, M. G., Roy, P. H., Ouellette, M., Boily, M. J., Trépanier, H., Picard, F. J., Boudreau, D. K., Pelletier, R., Boissinot, M., Piché, Y., Sellam, A., Maheux, A. F., J Microbiol Methods, 2016, 10.1016/j.mimet.2016.09.020
  • In primary human monocyte-derived macrophages exposed to Human immunodeficiency virus type 1, does the increased intracellular growth of Leishmania infantum rely on its enhanced uptake?, Tremblay, M. J., Papadopoulou, B., Ouellette, M., Messier, N., Thibault, S., Zhao, C., J Gen Virol, 2006, 10.1099/vir.0.81647-0
  • Inactivation of the Leishmania tarentolae pterin transporter (BT1) and reductase (PTR1) genes leads to viable parasites with changes in folate metabolism and hypersensitivity to the antifolate methotrexate, Ouellette, M., Roy, G., Kündig, C., El Fadili, A., J Biol Chem, 2004, 10.1074/jbc.M400652200
  • Formation of linear amplicons with inverted duplications in Leishmania requires the MRE11 nuclease, Ouellette, M., Masson, J. Y., Légaré, D., Mukherjee, A., Genois, M. M., Laffitte, M. C., PLoS Genet, 2014, 10.1371/journal.pgen.1004805
  • Gene expression profiling and molecular characterization of antimony resistance in Leishmania amazonensis, Ouellette, M., Frézard, F., Melo, M. N., Corbeil, J., Légaré, D., Raymond, F., Coelho, A. C., do Monte-Neto, R. L., PLoS Negl Trop Dis, 2011, 10.1371/journal.pntd.0001167
  • CRISPR-Cas9 high-throughput screening to study drug resistance in Leishmania infantum, Ana María Mejía-Jaramillo, Marc Ouellette, Christopher Fernandez-Prada, Philippe Leprohon, Marine Queffeulou, mBio, 2024, 10.1128/mbio.00477-24
  • Gene disruption of the P-glycoprotein related gene pgpa of Leishmania tarentolae, Ouellette, M., Olivier, M., Rosen, B. P., Roy, G., Dey, S., Papadopoulou, B., Biochem Biophys Res Commun, 1996, 10.1006/bbrc.1996.1098
  • Functional cloning of the miltefosine transporter. A novel P-type phospholipid translocase from Leishmania involved in drug resistance, Castanys, S., Ouellette, M., Gamarro, F., Pérez-Victoria, F. J., J Biol Chem, 2003, 10.1074/jbc.M308352200
  • Separation of basic proteins from Leishmania using a combination of Free flow electrophoresis (FFE) and 2D electrophoresis (2-DE) under basic conditions, Ouellette, M., Racine, G., Brotherton, M. C., Methods Mol Biol, 2015, 10.1007/978-1-4939-1438-8_15
  • A proteomic approach to identify developmentally regulated proteins in Leishmania infantum, Papadopoulou, B., Ouellette, M., El Fakhry, Y., Proteomics, 2002, 10.1002/1615-9861(200208)2:8<1007::AID-PROT1007>3.0.CO;2-G
  • Gene expression modulation and the molecular mechanisms involved in Nelfinavir resistance in Leishmania donovani axenic amastigotes, Tremblay, M. J., Ouellette, M., Corbeil, J., Jalaguier, P., Ritt, J. F., Raymond, F., Lodge, R., Kumar, P., Mol Microbiol, 2013, 10.1111/mmi.12298
  • Precise insertion of antibiotic resistance determinants into Tn21-like transposons: nucleotide sequence of the OXA-1 beta-lactamase gene, Roy, P. H., Bissonnette, L., Ouellette, M., Proc Natl Acad Sci U S A, 1987
  • Oligonucleotide probes for the detection of TEM-1 and TEM-2 beta-lactamase genes and their transposons, Roy, P. H., Bazin, R., Rossi, J. J., Ouellette, M., Can J Microbiol, 1987
  • Autonomous replication of bacterial DNA plasmid oligomers in Leishmania, Ouellette, M., Roy, G., Papadopoulou, B., Mol Biochem Parasitol, 1994
  • Deep-sequencing revealing mutation dynamics in the miltefosine transporter gene in Leishmania infantum selected for miltefosine resistance, Ouellette, M., Légaré, D., Leprohon, P., Laffitte, M. C., Parasitol Res, 2016, 10.1007/s00436-016-5195-y
  • Coordinating funding in public health emergencies, GloPID-R members, Ouellette, M., Mphahlele, J., Hwang, E. S., Delfraissy, J. F., Colli, W., Matthiessen, L., Lancet, 2016, 10.1016/S0140-6736(16)30604-3
  • A proteomic analysis of penicillin resistance in Streptococcus pneumoniae reveals a novel role for PstS, a subunit of the phosphate ABC transporter, Ouellette, M., Légaré, D., Drummelsmith, J., Bergeron, M. G., Weiss, K., Papadopoulou, B., Ménard, F., Brochu, V., Soualhine, H., Mol Microbiol, 2005, 10.1111/j.1365-2958.2005.04914.x
  • Differential protein expression analysis of Leishmania major reveals novel roles for methionine adenosyltransferase and S-adenosylmethionine in methotrexate resistance, Ouellette, M., Trudel, N., Girard, I., Drummelsmith, J., J Biol Chem, 2004, 10.1074/jbc.M405183200
  • Inhibition of MRSA and of Clostridium difficile by durancin 61A: synergy with bacteriocins and antibiotics, Fliss, I., Ouellette, M., Ben Hamida, J., Bergeron, M. G., Kourda, R., Gingras, H., Hammami, R., Hanchi, H., Future Microbiol, 2017, 10.2217/fmb-2016-0113
  • Drug resistance analysis by next generation sequencing in Leishmania, Ouellette, M., Monte-Neto, R., Gazanion, É, Fernandez-Prada, C., Leprohon, P., Int J Parasitol Drugs Drug Resist, 2015, 10.1016/j.ijpddr.2014.09.005
  • Pterin and folate reduction by the Leishmania tarentolae H locus short-chain dehydrogenase/reductase PTR1, Ouellette, M., Lin, S. X., Whiteley, J. M., Bray, T., Papadopoulou, B., Chang, C. F., Leblanc, E., Wang, J., Arch Biochem Biophys, 1997, 10.1006/abbi.1997.0126
  • Inactivation of the cytosolic and mitochondrial serine hydroxymethyl transferase genes in Leishmania major, Ouellette, M., Roy, G., Mol Biochem Parasitol, 2015, 10.1016/j.molbiopara.2016.02.003
  • Rapid detection of group B streptococci in pregnant women at delivery, Fraser, W. D., Marcoux, S., Roy, P. H., Ouellette, M., Bernier, M., Gagnon, M., Picard, F. J., Ménard, C., Ke, D., Bergeron, M. G., N Engl J Med, 2000, 10.1056/NEJM200007203430303
  • The Leishmania ATP-binding cassette protein PGPA is an intracellular metal-thiol transporter ATPase, Ouellette, M., Papadopoulou, B., Haimeur, A., Rosen, B. P., Stierhof, Y. D., Mukhopadhyay, R., Richard, D., Légaré, D., J Biol Chem, 2001, 10.1074/jbc.M102351200
  • Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages, Papadopoulou, B., Olivier, M., Tamar, S., Fairlamb, A. H., Cunningham, M. L., Tovar, J., Ouellette, M., Dumas, C., EMBO J, 1997, 10.1093/emboj/16.10.2590
  • Resistance to antimony and treatment failure in human Leishmania (Viannia) infection, Saravia, N. G., Ouellette, M., Varona, M. X., Valderrama, M., Valderrama, L., Rojas, R., J Infect Dis, 2006, 10.1086/503371
  • Intracellular survival of Leishmania species that cause visceral leishmaniasis is significantly reduced by HIV-1 protease inhibitors, Tremblay, M. J., Ouellette, M., Sundar, S., Messier, N., Garg, R., Trudel, N., J Infect Dis, 2008, 10.1086/592280
  • Proteome mapping of the protozoan parasite Leishmania and application to the study of drug targets and resistance mechanisms, Ouellette, M., Messier, N., Girard, I., Brochu, V., Drummelsmith, J., Mol Cell Proteomics, 2003, 10.1074/mcp.M200085-MCP200
  • DNA transformation of Leishmania infantum axenic amastigotes and their use in drug screening, Ouellette, M., Papadopoulou, B., Lemesre, J. L., Roy, G., Sereno, D., Antimicrob Agents Chemother, 2001, 10.1128/AAC.45.4.1168-1173.2001
  • Role of ABC transporter MRPA, gamma-glutamylcysteine synthetase and ornithine decarboxylase in natural antimony-resistant isolates of Leishmania donovani, Madhubala, R., Ouellette, M., Chatterjee, M., Girard, I., Roy, G., Singh, S., Padmanabhan, P. K., Mukherjee, A., J Antimicrob Chemother, 2007, 10.1093/jac/dkl494
  • Multiplex PCR assays for the detection of clinically relevant antibiotic resistance genes in staphylococci isolated from patients infected after cardiac surgery. The ESPRIT Trial, Bergeron, M. G., Ouellette, M., Roy, P. H., Grenier, L., Picard, F. J., Martineau, F., J Antimicrob Chemother, 2000
  • Development of a PCR assay for identification of staphylococci at genus and species levels, Bergeron, M. G., Ouellette, M., Roy, P. H., Paradis, S., Ke, D., Picard, F. J., Martineau, F., J Clin Microbiol, 2001, 10.1128/JCM.39.7.2541-2547.2001
  • Genomic characterization of ciprofloxacin resistance in a laboratory-derived mutant and a clinical isolate of Streptococcus pneumoniae, Ouellette, M., Leprohon, P., Zhanel, G. G., Soualhine, H., Fani, F., Billal, D. S., Lupien, A., Antimicrob Agents Chemother, 2013, 10.1128/AAC.00418-13
  • ATP-binding cassette transporters: from multidrug resistance to genetic disease, Gosau, Austria, 20-27 February 1999, Rosen, B. P., Ouellette, M., Dey, S., Drug Resist Updat, 1999, 10.1054/drup.1999.0072
  • Modulation of gene expression in Leishmania drug resistant mutants as determined by targeted DNA microarrays, Ouellette, M., Légaré, D., Bergeron, M. G., Corbeil, J., Papadopoulou, B., Messier, N., Richard, D., Briand, G., Peytavi, R., El Fadili, A., Marquis, N., Brochu, C., Trudel, N., Guimond, C., Nucleic Acids Res, 2003
  • Drug resistance in Leishmania: similarities and differences to other organisms, Ouellette, M., Singh, A., Kündig, C., Papadopoulou, B., Drug Resist Updat, 1998
  • High affinity S-Adenosylmethionine plasma membrane transporter of Leishmania is a member of the folate biopterin transporter (FBT) family, Ouellette, M., Ahmed Ouameur, A., Dridi, L., J Biol Chem, 2010, 10.1074/jbc.M110.114520
  • Frequent amplification of a short chain dehydrogenase gene in methotrexate resistant Leishmania, Ouellette, M., Papadopoulou, B., Adv Exp Med Biol, 1993
  • The Canadian Institutes of Health Research Institute of Infection and Immunity response to the threat of antimicrobial resistance, Ouellette, M., Raven, J. F., Rev Panam Salud Publica, 2011
  • New Resistance Mutations Linked to Decreased Susceptibility to Solithromycin in Streptococcus pneumoniae Revealed by Chemogenomic Screens, Marc Ouellette, Philippe Leprohon, Kevin Patron, Chantal Godin, Flora Peillard-Fiorente, Hélène Gingras, Antimicrobial Agents and Chemotherapy, 2023, 10.1128/aac.00395-23
  • A genomic approach to understand interactions between Streptococcus pneumoniae and its bacteriophages, Ouellette, M., Moineau, S., Ouennane, S., Gingras, H., Leprohon, P., BMC Genomics, 2015, 10.1186/s12864-015-2134-8
  • Modulation of gene expression in drug resistant Leishmania is associated with gene amplification, gene deletion and chromosome aneuploidy, Ouellette, M., Papadopoulou, B., Olivier, M., Tremblay, M. J., Corbeil, J., Rigault, P., Boisvert, S., Ouameur, A. A., Raymond, F., Légaré, D., Ubeda, J. M., Genome Biol, 2008, 10.1186/gb-2008-9-7-r115
  • Proteomic and genomic analyses of antimony resistant Leishmania infantum mutant, Ouellette, M., Droit, A., Poirier, G. G., Légaré, D., Leprohon, P., Bourassa, S., Brotherton, M. C., PLoS One, 2013, 10.1371/journal.pone.0081899
  • Protection against Leishmania major challenge infection in mice vaccinated with live recombinant parasites expressing a cytotoxic gene, Papadopoulou, B., Ouellette, M., Bergeron, M. G., Harvie, P., Olivier, M., Muyombwe, A., J Infect Dis, 1998
  • Linear amplicons as precursors of amplified circles in methotrexate-resistant Leishmania tarentolae, Ouellette, M., Roy, G., Kündig, C., Grondin, K., Nucleic Acids Res, 1998
  • The impact of distinct culture media in Leishmania infantum biology and infectivity, Cordeiro-DA-Silva, A., Ouellette, M., Moreira, D., Silva, C., Silvestre, R., Cunha, J., Santarém, N., Parasitology, 2014, 10.1017/S0031182013001388
  • A natural mutation of the amino acid residue at position 60 destroys staphylococcal enterotoxin A murine T-cell mitogenicity, Ouellette, M., Mourad, W., Hébert, J., Valet, J. P., Lévéillé, C., al-Daccak, R., Mahana, W., Infect Immun, 1995
  • Next Generation Vaccine Biomarkers workshop October 30-31, 2014--Ottawa, Canada, Richards, J. C., Barreto, L., Krishnan, L., Conlan, J. W., Raven, J. F., Ouellette, M., Spika, J., Fulton, K. M., Twine, S. M., Hum Vaccin Immunother, 2015, 10.1080/21645515.2015.1083663
  • Roles of Rad51 paralogs for promoting homologous recombination in Leishmania infantum, Masson, J. Y., Ouellette, M., Poirier, G. G., Roy, G., Éthier, C., Plourde, M., Genois, M. M., Nucleic Acids Res, 2015, 10.1093/nar/gkv118
  • Microbial multidrug resistance, Kündig, C., Ouellette, M., Int J Antimicrob Agents, 1997
  • Modulation in aquaglyceroporin AQP1 gene transcript levels in drug-resistant Leishmania, Ouellette, M., Mukhopadhyay, R., Rosen, B. P., Gourbal, B., Marquis, N., Mol Microbiol, 2005, 10.1111/j.1365-2958.2005.04782.x
  • Correlation between the resistance genotype determined by multiplex PCR assays and the antibiotic susceptibility patterns of Staphylococcus aureus and Staphylococcus epidermidis, Bergeron, M. G., Ouellette, M., Roy, P. H., Ménard, C., Lansac, N., Picard, F. J., Martineau, F., Antimicrob Agents Chemother, 2000
  • Targeted insertion of the neomycin phosphotransferase gene into the tubulin gene cluster of Trypanosoma brucei, Borst, P., Ouellette, M., ten Asbroek, A. L., Nature, 1990, 10.1038/348174a0
  • Homologous recombination between direct repeat sequences yields P-glycoprotein containing amplicons in arsenite resistant Leishmania, Ouellette, M., Papadopoulou, B., Grondin, K., Nucleic Acids Res, 1993
  • Stage specific gene expression and cellular localization of two isoforms of the serine hydroxymethyltransferase in the protozoan parasite Leishmania, Ouellette, M., Girard, I., Foucher, A., Gagnon, D., Mol Biochem Parasitol, 2006, 10.1016/j.molbiopara.2006.06.009
  • ABC proteins of Leishmania, Ouellette, M., Papadopoulou, B., Richard, D., Singh, A. K., Cayer, S., Légaré, D., J Bioenerg Biomembr, 2001
  • The heat shock protein HSP70 and heat shock cognate protein HSC70 contribute to antimony tolerance in the protozoan parasite leishmania, Ouellette, M., Haimeur, A., Brochu, C., Cell Stress Chaperones, 2004
  • Tolerance to drug-induced cell death favours the acquisition of multidrug resistance in Leishmania, Ouellette, M., Leprohon, P., Moreira, W., Cell Death Dis, 2011, 10.1038/cddis.2011.83
  • Nisin is an effective inhibitor of Clostridium difficile vegetative cells and spore germination, Fliss, I. L., Ouellette, M., Bergeron, M. G., Dridi, L., Le Lay, C., J Med Microbiol, 2016, 10.1099/jmm.0.000202
  • Identification of developmentally-regulated proteins in Leishmania panamensis by proteome profiling of promastigotes and axenic amastigotes, Ouellette, M., Girard, I., Burchmore, R., Drummelsmith, J., Gomez, M. A., Vasquez, J. J., Walker, J., Mol Biochem Parasitol, 2006, 10.1016/j.molbiopara.2006.01.008
  • Chromosomal Translocations in the Parasite Leishmania by a MRE11/RAD50-Independent Microhomology-Mediated End Joining Mechanism, Ouellette, M., Masson, J. Y., Légaré, D., Hainse, M., Leprohon, P., Laffitte, M. C., PLoS Genet, 2016, 10.1371/journal.pgen.1006117
  • Long-Term Prevention of Arthroplasty Infections via Incorporation of Activated AgNbO3 Nanoparticles in PMMA Bone Cement, Marc Ouellette, Houshang Alamdari, Hossein Salimnia, Rahul Vaidya, Simon Laliberté-Riverin, Fereshteh Fani, Cyrus Talebpour, ACS Applied Bio Materials, 2024, 10.1021/acsabm.4c00373
  • Gene expression modulation is associated with gene amplification, supernumerary chromosomes and chromosome loss in antimony-resistant Leishmania infantum, Ouellette, M., Corbeil, J., Hardiman, G., Madore, E., Raymond, F., Légaré, D., Leprohon, P., Nucleic Acids Res, 2009, 10.1093/nar/gkn1069
  • Preventing antibiotic resistance through rapid genotypic identification of bacteria and of their antibiotic resistance genes in the clinical microbiology laboratory, Ouellette, M., Bergeron, M. G., J Clin Microbiol, 1998
  • Involvement of zinc in the binding of Mycoplasma arthritidis-derived mitogen to the proximity of the HLA-DR binding groove regardless of histidine 81 of the beta chain, Mourad, W., Al-Daccak, R., Younes, S., Li, H., Ouellette, M., Langlois, M. A., Etongué-Mayer, P., Eur J Immunol, 2002, 10.1002/1521-4141(200201)32:1<50::AID-IMMU50>3.0.CO;2-A
  • Development of a rapid PCR assay specific for Staphylococcus saprophyticus and application to direct detection from urine samples, Bergeron, M. G., Ouellette, M., Roy, P. H., Ménard, C., Picard, F. J., Martineau, F., J Clin Microbiol, 2000
  • Structure-function analysis of the highly conserved charged residues of the membrane protein FT1, the main folic acid transporter of the protozoan parasite Leishmania, Ouellette, M., Haimeur, A., Dridi, L., Biochem Pharmacol, 2010, 10.1016/j.bcp.2009.07.019
  • A recombinant non-pathogenic Leishmania vaccine expressing human immunodeficiency virus 1 (HIV-1) Gag elicits cell-mediated immunity in mice and decreases HIV-1 replication in human tonsillar tissue following exposure to HIV-1 infection, Papadopoulou, B., Tremblay, M. J., Ouellette, M., Zhao, C., Breton, M., J Gen Virol, 2007, 10.1099/vir.0.81995-0
  • High level arsenite resistance in Leishmania tarentolae is mediated by an active extrusion system, Ouellette, M., Rosen, B. P., Dou, D., Grondin, K., Roy, G., Haimeur, A., Papadopoulou, B., Dey, S., Mol Biochem Parasitol, 1994
  • Nelfinavir, an HIV-1 protease inhibitor, induces oxidative stress-mediated, caspase-independent apoptosis in Leishmania amastigotes, Tremblay, M. J., Ouellette, M., Ouellet, M., Trudel, N., Lodge, R., Kumar, P., PLoS Negl Trop Dis, 2010, 10.1371/journal.pntd.0000642
  • Genetic, biochemical and molecular characterization of strains of Vibrio cholerae multiresistant to antibiotics, Courvalin, P., Gerbaud, G., Ouellette, M., Ann Inst Pasteur Microbiol, 1988
  • Contribution of the Leishmania P-glycoprotein-related gene ltpgpA to oxyanion resistance, Ouellette, M., Rosen, B. P., Dey, S., Roy, G., Papadopoulou, B., J Biol Chem, 1994
  • Genome-wide stochastic adaptive DNA amplification at direct and inverted DNA repeats in the parasite Leishmania, Ouellette, M., Corbeil, J., Papadopoulou, B., Leprohon, P., Lapointe, A., Roy, G., Gingras, H., Plourde, M., Mukherjee, A., Raymond, F., Ubeda, J. M., PLoS Biol, 2014, 10.1371/journal.pbio.1001868
  • New mechanisms of drug resistance in parasitic protozoa, Ouellette, M., Borst, P., Annu Rev Microbiol, 1995, 10.1146/annurev.mi.49.100195.002235
  • Amplification of the ABC transporter gene PGPA and increased trypanothione levels in potassium antimonyl tartrate (SbIII) resistant Leishmania tarentolae, Ouellette, M., Papadopoulou, B., Genest, P., Brochu, C., Haimeur, A., Mol Biochem Parasitol, 2000
  • Discovery of factors linked to antimony resistance in Leishmania panamensis through differential proteome analysis, Saravia, N. G., Gomez, M. A., Ouellette, M., Roy, G., Burchmore, R., Drummelsmith, J., Vasquez, J. J., Gongora, R., Walker, J., Mol Biochem Parasitol, 2012, 10.1016/j.molbiopara.2012.03.002
  • Analysis of stage-specific expression of basic proteins in Leishmania infantum, Ouellette, M., Papadopoulou, B., Drummelsmith, J., Foucher, A. L., Racine, G., Brotherton, M. C., J Proteome Res, 2010, 10.1021/pr100048m
  • Genome sequencing of the lizard parasite Leishmania tarentolae reveals loss of genes associated to the intracellular stage of human pathogenic species, Corbeil, J., Ouellette, M., Papadopoulou, B., Tremblay, M. J., Olivier, M., Stanke, M., Isnard, A., Légaré, D., Ritt, J. F., Roy, G., Boisvert, S., Raymond, F., Nucleic Acids Res, 2012, 10.1093/nar/gkr834
  • Gene amplification in amphotericin B-resistant Leishmania tarentolae, Ouellette, M., Papadopoulou, B., Singh, A. K., Exp Parasitol, 2001, 10.1006/expr.2001.4663
  • Homology of ORFs from Tn2603 and from R46 to site-specific recombinases, Roy, P. H., Ouellette, M., Nucleic Acids Res, 1987
  • Genomic analysis and reconstruction of cefotaxime resistance in Streptococcus pneumoniae, Ouellette, M., Leprohon, P., Brotherton, M. C., Fani, F., J Antimicrob Chemother, 2013, 10.1093/jac/dkt113
  • Use of tuf sequences for genus-specific PCR detection and phylogenetic analysis of 28 streptococcal species, Bergeron, M. G., Roy, P. H., Ouellette, M., Richard, D., Huletsky, A., Boissinot, M., Boudreau, D. K., Ke, D., Picard, F. J., J Clin Microbiol, 2004, 10.1128/JCM.42.8.3686-3695.2004
  • Different Mutations in a P-type ATPase Transporter in Leishmania Parasites are Associated with Cross-resistance to Two Leading Drugs by Distinct Mechanisms, Ouellette, M., Smith, T. K., Leprohon, P., Rivas, L., Roy, G., Roberts, M., Brotherton, M. C., Vincent, I. M., Fernandez-Prada, C., PLoS Negl Trop Dis, 2016, 10.1371/journal.pntd.0005171
  • Multidrug resistance and ABC transporters in parasitic protozoa, Papadopoulou, B., Légaré, D., Ouellette, M., J Mol Microbiol Biotechnol, 2001
  • Comparative proteomics analyses reveal a potential biomarker for the detection of vancomycin-intermediate Staphylococcus aureus strains, Ouellette, M., Poirier, G. G., Bergeron, M. G., Winstall, E., Drummelsmith, J., J Proteome Res, 2007, 10.1021/pr070521m
  • Holistic understanding of trimethoprim resistance in Streptococcus pneumoniae using an integrative approach of genome-wide association study, resistance reconstruction, and machine learning, Marc Ouellette, Philippe Leprohon, Macha Nikolski, Alexis Groppi, Jie Feng, Chantal Godin, Hélène Gingras, Nguyen-Phuong Pham, mBio, 2024, 10.1128/mbio.01360-24
  • The P-glycoprotein-related gene family in Leishmania, Ouellette, M., Hettema, E., Légaré, D., Mol Biochem Parasitol, 1994
  • Mode of action of silver-based perovskite against Gram-negative bacteria, Marc Ouellette, Houshang Alamdari, Hossein Salimnia, Philippe Leprohon, Cyrus Talebpour, Fereshteh Fani, Microbiology Spectrum, 2025, 10.1128/spectrum.01648-24
  • Intrachromosomal tandem duplication and repeat expansion during attempts to inactivate the subtelomeric essential gene GSH1 in Leishmania, Ouellette, M., Langston, L. D., Mukherjee, A., Nucleic Acids Res, 2011, 10.1093/nar/gkr494
  • Episomal and stable expression of the luciferase reporter gene for quantifying Leishmania spp. infections in macrophages and in animal models, Papadopoulou, B., Olivier, M., Ouellette, M., Tremblay, M. J., Singh, A. K., Wu, Y., Sereno, D., Dumas, C., Roy, G., Mol Biochem Parasitol, 2000
  • Whole-genome comparative RNA expression profiling of axenic and intracellular amastigote forms of Leishmania infantum, Papadopoulou, B., Ouellette, M., Corbeil, J., Raymond, F., Rochette, A., Mol Biochem Parasitol, 2009, 10.1016/j.molbiopara.2008.12.012
  • Analysis by using DNA probes of the OXA-1 beta-lactamase gene and its transposon, Roy, P. H., Ouellette, M., Antimicrob Agents Chemother, 1986
  • A protein of the leucine-rich repeats (LRRs) superfamily is implicated in antimony resistance in Leishmania infantum amastigotes, Ouellette, M., Papadopoulou, B., Messier, N., Roy, G., Sereno, D., Légaré, D., Haimeur, A., Genest, P. A., Mol Biochem Parasitol, 2008, 10.1016/j.molbiopara.2007.11.008
  • Generation of an aquaglyceroporin AQP1 null mutant in Leishmania major, Ouellette, M., Mukhopadhyay, R., Monte-Neto, R. L., Mandal, G., Ubeda, J. M., Plourde, M., Mol Biochem Parasitol, 2015, 10.1016/j.molbiopara.2015.07.003
  • Residues involved in co-factor and substrate binding of the short-chain dehydrogenase/reductase PTR1 producing methotrexate resistance in Leishmania, Ouellette, M., Bernatchez, C., Papadopoulou, B., Leblanc, E., Eur J Biochem, 1998
  • Mechanisms of drug resistance in Leishmania, Papadopoulou, B., Ouellette, M., Parasitol Today, 1993
  • Preventing antibiotic resistance using rapid DNA-based diagnostic tests, Ouellette, M., Bergeron, M. G., Infect Control Hosp Epidemiol, 1998
  • Involvement of Dcr1 in post-transcriptional regulation of gene expression in Schizosaccharomyces pombe, Provost, P., Ouellette, M., Rohani, M., Plante, P., Gobeil, L. A., Front Biosci, 2008
  • ABC transporters in Leishmania and their role in drug resistance, Papadopoulou, B., Brochu, C., Roy, G., Grondin, K., Haimeur, A., Légaré, D., Ouellette, M., Drug Resist Updat, 1998
  • Novel genus-specific PCR-based assays for rapid identification of Neisseria species and Neisseria meningitidis, Bergeron, M. G., Roy, P. H., Ouellette, M., Boissinot, M., Ménard, C., Picard, F. J., Lansac, N., Eur J Clin Microbiol Infect Dis, 2000
  • Leishmania major LmACR2 is a pentavalent antimony reductase that confers sensitivity to the drug pentostam, Mukhopadhyay, R., Rosen, B. P., Ouellette, M., Messier, N., Zhou, Y., J Biol Chem, 2004, 10.1074/jbc.M404383200
  • Modulation of Leishmania ABC protein gene expression through life stages and among drug-resistant parasites, Ouellette, M., Papadopoulou, B., Girard, I., Légaré, D., Leprohon, P., Eukaryot Cell, 2006, 10.1128/EC.00152-06
  • Structure of pteridine reductase (PTR1) from Leishmania tarentolae, Varughese, K. I., Whiteley, J. M., Matthews, D., Ferre, R. A., Zhao, M., Ouellette, M., Bray, T., Zhao, H., Acta Crystallogr D Biol Crystallogr, 2003
  • A proteomics screen implicates HSP83 and a small kinetoplastid calpain-related protein in drug resistance in Leishmania donovani clinical field isolates by modulating drug-induced programmed cell death, Ouellette, M., Drummelsmith, J., Sundar, S., Girard, I., Gourbal, B., Vergnes, B., Mol Cell Proteomics, 2007, 10.1074/mcp.M600319-MCP200
  • Thiol-induced reduction of antimony(V) into antimony(III): a comparative study with trypanothione, cysteinyl-glycine, cysteine and glutathione, Frézard, F., Ouellette, M., Brochu, C., Demicheli, C., Martins, P. S., Ferreira, C.os S, Biometals, 2003
  • Biochemical characterization of Leishmania major aquaglyceroporin LmAQP1: possible role in volume regulation and osmotaxis, Mukhopadhyay, R., Bhattacharjee, H., Ouellette, M., LeFurgey, A., Zhou, Y., Uzcategui, N. L., Figarella, K., Mol Microbiol, 2007, 10.1111/j.1365-2958.2007.05845.x

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2020/04
  • Jade-Eva Potvin - Doctorat - 2021/01
  • Sophia Bigot - Doctorat - 2023/09
  • Flora Peillard - Doctorat - 2024/05
  • Khaled Abdallah - Doctorat - 2024/09

Encadrement d'étudiant(e)s

Direction de recherche dans les domaines suivants :

  • Biologie cellulaire et moléculaire
  • Microbiologie-immunologie

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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