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Marc Ouellette

Professeur titulaire

Directeur(trice), Centre de recherche en infectiologie

marc.ouellette@fmed.ulaval.ca

Département de microbiologie-infectiologie et d'immunologie

Centre de recherche en infectiologie

Centre de recherche du CHU de Québec - Université Laval

Partager la fiche :

Contribution à la recherche

Thématiques de recherche de la Faculté de médecine

Bioinformatique / données massives (big data)
Immunologie-infectiologie

Projets de recherche en cours

Genomics of antimicrobial resistance and drug/target discovery - Instituts de recherche en santé du Canada - Subventions Fondation, chercheur principal - 2019-07-01 au 2027-06-30
AviBiocin II Les bactériocines comme solution antimicrobienne innovante pour la réduction de l’usage des antibiotiques dans le secteur aviaire: de la preuve de concept à la commercialisation - Centre de recherches pour le développement international - Appel de propositions : Élaborer des solutions vétérinaires innovatrices pour la résistance aux antimicrobiens – phase 2, co-chercheur - 2024-01-01 au 2027-01-31
Appui du VRRCI aux activités entourant le 50e anniversaire du CRI - Université Laval - Fonds internes - BDR - Contributions, chercheur principal - 2024-09-01 au 2025-08-31

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Financements des 2 dernières années

Caractérisation d'un traitement anti-buée en milieu médical - MITACS Inc. - Accélération Québec (MITACS et gouvernement provincial), chercheur principal - 2023-05-15 au 2025-07-14
Nouveaux dérivés de triterpènes biosourcés pour le contrôle de parasites protozoaires - Matrix Innovation, Fondation du CHU de Québec, Ministère de l'Économie et de l'Innovation et de l'énergie - Projets de maturation technologique PSO – volet 2d, co-chercheur - 2023-07-10 au 2024-07-10
Chaire de recherche du Canada sur la résistance aux antiantimicrobiens - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2017-04-01 au 2024-03-31
Les bactériocines : une alternative naturelle fort prometteuse pour le remplacement des antibiotiques en production avicole. - Centre de recherches pour le développement international - Appel de propositions : Élaborer des solutions vétérinaires innovatrices pour la résistance aux antimicrobiens, co-chercheur - 2019-04-01 au 2022-03-31

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Publications

Mechanisms of drug resistance in Leishmania, Papadopoulou, B., Ouellette, M., Parasitol Today, 1993
Amplification of the ABC transporter gene PGPA and increased trypanothione levels in potassium antimonyl tartrate (SbIII) resistant Leishmania tarentolae, Ouellette, M., Papadopoulou, B., Genest, P., Brochu, C., Haimeur, A., Mol Biochem Parasitol, 2000
Involvement of zinc in the binding of Mycoplasma arthritidis-derived mitogen to the proximity of the HLA-DR binding groove regardless of histidine 81 of the beta chain, Mourad, W., Al-Daccak, R., Younes, S., Li, H., Ouellette, M., Langlois, M. A., Etongué-Mayer, P., Eur J Immunol, 2002, 10.1002/1521-4141(200201)32:1<50::AID-IMMU50>3.0.CO;2-A
Multiplex PCR assays for the detection of clinically relevant antibiotic resistance genes in staphylococci isolated from patients infected after cardiac surgery. The ESPRIT Trial, Bergeron, M. G., Ouellette, M., Roy, P. H., Grenier, L., Picard, F. J., Martineau, F., J Antimicrob Chemother, 2000
Novel genus-specific PCR-based assays for rapid identification of Neisseria species and Neisseria meningitidis, Bergeron, M. G., Roy, P. H., Ouellette, M., Boissinot, M., Ménard, C., Picard, F. J., Lansac, N., Eur J Clin Microbiol Infect Dis, 2000
Delving in folate metabolism in the parasite Leishmania major through a chemogenomic screen and methotrexate selection, Marc Ouellette, Philippe Leprohon, Sophia Bigot, PLOS Neglected Tropical Diseases, 2023, 10.1371/journal.pntd.0011458
Selective killing of Leishmania amastigotes expressing a thymidine kinase suicide gene, Papadopoulou, B., Ouellette, M., Olivier, M., Muyombwe, A., Exp Parasitol, 1997, 10.1006/expr.1996.4115
Generation of Leishmania hybrids by whole genomic DNA transformation, Ouellette, M., Leprohon, P., Coelho, A. C., PLoS Negl Trop Dis, 2012, 10.1371/journal.pntd.0001817
Multiple mutations in heterogeneous miltefosine-resistant Leishmania major population as determined by whole genome sequencing, Ouellette, M., Corbeil, J., Leprohon, P., Mukherjee, A., Boisvert, S., Coelho, A. C., PLoS Negl Trop Dis, 2012, 10.1371/journal.pntd.0001512
Analysis of membrane-enriched and high molecular weight proteins in Leishmania infantum promastigotes and axenic amastigotes, Ouellette, M., Papadopoulou, B., Leprohon, P., Ouameur, A. A., Racine, G., Brotherton, M. C., J Proteome Res, 2012, 10.1021/pr201248h
CRISPR-Cas9 high-throughput screening to study drug resistance in Leishmania infantum, Ana María Mejía-Jaramillo, Marc Ouellette, Christopher Fernandez-Prada, Philippe Leprohon, Marine Queffeulou, mBio, 2024, 10.1128/mbio.00477-24
A protein of the leucine-rich repeats (LRRs) superfamily is implicated in antimony resistance in Leishmania infantum amastigotes, Ouellette, M., Papadopoulou, B., Messier, N., Roy, G., Sereno, D., Légaré, D., Haimeur, A., Genest, P. A., Mol Biochem Parasitol, 2008, 10.1016/j.molbiopara.2007.11.008
The P-glycoprotein-related gene family in Leishmania, Ouellette, M., Hettema, E., Légaré, D., Mol Biochem Parasitol, 1994
Resistance of Leishmania donovani to sodium stibogluconate is related to the expression of host and parasite gamma-glutamylcysteine synthetase, Mullen, A. B., Roberts, C. W., Ouellette, M., Légaré, D., Henriquez, F. L., Hutchison, S., Carter, K. C., Antimicrob Agents Chemother, 2006, 10.1128/AAC.50.1.88-95.2006
Genome-wide stochastic adaptive DNA amplification at direct and inverted DNA repeats in the parasite Leishmania, Ouellette, M., Corbeil, J., Papadopoulou, B., Leprohon, P., Lapointe, A., Roy, G., Gingras, H., Plourde, M., Mukherjee, A., Raymond, F., Ubeda, J. M., PLoS Biol, 2014, 10.1371/journal.pbio.1001868
Genomic analyses of DNA transformation and penicillin resistance in Streptococcus pneumoniae clinical isolates, Ouellette, M., Bergeron, M. G., Zhanel, G. G., Leprohon, P., Fani, F., Antimicrob Agents Chemother, 2014, 10.1128/AAC.01311-13
Drug resistance in Leishmania: similarities and differences to other organisms, Ouellette, M., Singh, A., Kündig, C., Papadopoulou, B., Drug Resist Updat, 1998
Correlation between microarray DNA hybridization efficiency and the position of short capture probe on the target nucleic acid, Bergeron, M. G., Ouellette, M., Huletsky, A., Picard, F. J., Boissinot, M., Bissonnette, L., Boissinot, K., Raymond, F. R., Liu-Ying, T., Peytavi, R., Biotechniques, 2005
Amplification of ABC transporter gene pgpA and of other heavy metal resistance genes in Leishmania tarentolae and their study by gene transfection and gene disruption, Papadopoulou, B., Légaré, D., Grondin, K., Haimeur, A., Ouellette, M., Methods Enzymol, 1998
Residues involved in co-factor and substrate binding of the short-chain dehydrogenase/reductase PTR1 producing methotrexate resistance in Leishmania, Ouellette, M., Bernatchez, C., Papadopoulou, B., Leblanc, E., Eur J Biochem, 1998
High level arsenite resistance in Leishmania tarentolae is mediated by an active extrusion system, Ouellette, M., Rosen, B. P., Dou, D., Grondin, K., Roy, G., Haimeur, A., Papadopoulou, B., Dey, S., Mol Biochem Parasitol, 1994
Glucantime-resistant Leishmania tropica isolated from Iranian patients with cutaneous leishmaniasis are sensitive to alternative antileishmania drugs, Mohebali, M., Ouellette, M., Roy, G., Meamar, A. R., Khamesipour, A., Boucher, P., Hadighi, R., Parasitol Res, 2007, 10.1007/s00436-007-0638-0
Differences in antibiotic-induced oxidative stress responses between laboratory and clinical isolates of Streptococcus pneumoniae, Ouellette, M., Leprohon, P., Bergeron, M. G., Lupien, A., Dridi, B., Antimicrob Agents Chemother, 2015, 10.1128/AAC.00316-15
Long-Term Prevention of Arthroplasty Infections via Incorporation of Activated AgNbO3 Nanoparticles in PMMA Bone Cement, Marc Ouellette, Houshang Alamdari, Hossein Salimnia, Rahul Vaidya, Simon Laliberté-Riverin, Fereshteh Fani, Cyrus Talebpour, ACS Applied Bio Materials, 2024, 10.1021/acsabm.4c00373
Deep-sequencing revealing mutation dynamics in the miltefosine transporter gene in Leishmania infantum selected for miltefosine resistance, Ouellette, M., Légaré, D., Leprohon, P., Laffitte, M. C., Parasitol Res, 2016, 10.1007/s00436-016-5195-y
Genome sequencing of the lizard parasite Leishmania tarentolae reveals loss of genes associated to the intracellular stage of human pathogenic species, Corbeil, J., Ouellette, M., Papadopoulou, B., Tremblay, M. J., Olivier, M., Stanke, M., Isnard, A., Légaré, D., Ritt, J. F., Roy, G., Boisvert, S., Raymond, F., Nucleic Acids Res, 2012, 10.1093/nar/gkr834
Mode of action of silver-based perovskite against Gram-negative bacteria, Marc Ouellette, Houshang Alamdari, Hossein Salimnia, Philippe Leprohon, Cyrus Talebpour, Fereshteh Fani, Microbiology Spectrum, 2025, 10.1128/spectrum.01648-24
New real-time PCR assay for rapid detection of methicillin-resistant Staphylococcus aureus directly from specimens containing a mixture of staphylococci, Bergeron, M. G., Roy, P. H., Ouellette, M., van Belkum, A., Picard, F. J., Bastien, M., Truchon, K., Gagnon, F., Bernier, M., Vaillancourt, M., Gagnon, M., Rossbach, V., Giroux, R., Huletsky, A., J Clin Microbiol, 2004
Reduced infectivity of a Leishmania donovani biopterin transporter genetic mutant and its use as an attenuated strain for vaccination, Ouellette, M., Olivier, M., Singh, A. K., Fillion, I., Dumas, C., Kündig, C., Breton, M., Roy, G., Papadopoulou, B., Infect Immun, 2002
Tolerance to drug-induced cell death favours the acquisition of multidrug resistance in Leishmania, Ouellette, M., Leprohon, P., Moreira, W., Cell Death Dis, 2011, 10.1038/cddis.2011.83
Whole genome analysis of linezolid resistance in Streptococcus pneumoniae reveals resistance and compensatory mutations, Ouellette, M., Légaré, D., Leprohon, P., Feng, J., Billal, D. S., BMC Genomics, 2011, 10.1186/1471-2164-12-512
A proteomic analysis of penicillin resistance in Streptococcus pneumoniae reveals a novel role for PstS, a subunit of the phosphate ABC transporter, Ouellette, M., Drummelsmith, J., Légaré, D., Bergeron, M. G., Weiss, K., Papadopoulou, B., Ménard, F., Brochu, V., Soualhine, H., Mol Microbiol, 2005, 10.1111/j.1365-2958.2005.04914.x
Modulation of gene expression in human macrophages treated with the anti-leishmania pentavalent antimonial drug sodium stibogluconate, Ouellette, M., Légaré, D., Tremblay, M. J., Bergeron, M., Gourbal, B., Roy, G., Messier, N., Imbeault, M., El Fadili, K., Antimicrob Agents Chemother, 2008, 10.1128/AAC.01183-07
Microbial multidrug resistance, Kündig, C., Ouellette, M., Int J Antimicrob Agents, 1997
Development of a PCR assay for identification of staphylococci at genus and species levels, Bergeron, M. G., Ouellette, M., Roy, P. H., Paradis, S., Ke, D., Picard, F. J., Martineau, F., J Clin Microbiol, 2001, 10.1128/JCM.39.7.2541-2547.2001
Antifolate resistance mechanisms from bacteria to cancer cells with emphasis on parasites, Papadopoulou, B., Kündig, C., Leblanc, E., Ouellette, M., Adv Exp Med Biol, 1998
Effect of polyglutamylation of methotrexate on its accumulation and the development of resistance in the protozoan parasite Leishmania, Ouellette, M., Kündig, C., Richard, D., El-Fadili, A., Biochem Pharmacol, 2003
Live nonpathogenic parasitic vector as a candidate vaccine against visceral leishmaniasis, Papadopoulou, B., Ouellette, M., Tremblay, M. J., Breton, M., Infect Immun, 2005, 10.1128/IAI.73.10.6372-6382.2005
ABC transporters in Leishmania and their role in drug resistance, Papadopoulou, B., Roy, G., Brochu, C., Grondin, K., Haimeur, A., Légaré, D., Ouellette, M., Drug Resist Updat, 1998
Spread of SHV-1 beta-lactamase in Escherichia coli isolated from fecal samples in Africa, Cluzel, R., Joly, B., Sirot, D., Ouellette, M., Shaokat, S., Antimicrob Agents Chemother, 1987
Mitochondrial Proteomics of Antimony and Miltefosine Resistant Leishmania infantum, Ouellette, M., Légaré, D., Racine, G., Vincent, I. M., Proteomes, 2015, 10.3390/proteomes3040328
A recombinant non-pathogenic Leishmania vaccine expressing human immunodeficiency virus 1 (HIV-1) Gag elicits cell-mediated immunity in mice and decreases HIV-1 replication in human tonsillar tissue following exposure to HIV-1 infection, Papadopoulou, B., Tremblay, M. J., Ouellette, M., Zhao, C., Breton, M., J Gen Virol, 2007, 10.1099/vir.0.81995-0
On Lactococcus lactis UL719 competitivity and nisin (Nisaplin(®)) capacity to inhibit Clostridium difficile in a model of human colon, Fliss, I., Ouellette, M., Hammami, R., Fernandez, B., Le Lay, C., Front Microbiol, 2015, 10.3389/fmicb.2015.01020
Recombinant Leishmania major secreting biologically active granulocyte-macrophage colony-stimulating factor survives poorly in macrophages in vitro and delays disease development in mice, Papadopoulou, B., Olivier, M., Ouellette, M., Matte, C., Roy, G., Muyombwe, A., Dumas, C., Infect Immun, 2003
Decreased glutamate transport in acivicin resistant Leishmania tarentolae, Marc Ouellette, Philippe Leprohon, Arijit Bhattacharya, Gaétan Roy, PLOS Neglected Tropical Diseases, 2021, 10.1371/journal.pntd.0010046
Down regulation of KMP-11 in Leishmania infantum axenic antimony resistant amastigotes as revealed by a proteomic screen, Ouellette, M., Jardim, A., Roy, G., Drummelsmith, J., El Fadili, K., Exp Parasitol, 2009, 10.1016/j.exppara.2009.05.013
Gene expression profiling and molecular characterization of antimony resistance in Leishmania amazonensis, Ouellette, M., Frézard, F., Melo, M. N., Corbeil, J., Légaré, D., Raymond, F., Coelho, A. C., do Monte-Neto, R. L., PLoS Negl Trop Dis, 2011, 10.1371/journal.pntd.0001167
Gene amplification in amphotericin B-resistant Leishmania tarentolae, Ouellette, M., Papadopoulou, B., Singh, A. K., Exp Parasitol, 2001, 10.1006/expr.2001.4663
Genomic analysis and reconstruction of cefotaxime resistance in Streptococcus pneumoniae, Ouellette, M., Leprohon, P., Brotherton, M. C., Fani, F., J Antimicrob Chemother, 2013, 10.1093/jac/dkt113
Chromosomal Translocations in the Parasite Leishmania by a MRE11/RAD50-Independent Microhomology-Mediated End Joining Mechanism, Ouellette, M., Masson, J. Y., Légaré, D., Hainse, M., Leprohon, P., Laffitte, M. C., PLoS Genet, 2016, 10.1371/journal.pgen.1006117
Intrachromosomal amplification, locus deletion and point mutation in the aquaglyceroporin AQP1 gene in antimony resistant Leishmania (Viannia) guyanensis, Ouellette, M., Frézard, F., Reis, P., Leprohon, P., Laffitte, M. C., Monte-Neto, R., PLoS Negl Trop Dis, 2015, 10.1371/journal.pntd.0003476
Interactions between BRCA2 and RAD51 for promoting homologous recombination in Leishmania infantum, Masson, J. Y., Ouellette, M., Coulombe, Y., Plourde, M., Roy, G., Paquet, E., Buisson, R., Ubeda, J. M., Mukherjee, A., Genois, M. M., Nucleic Acids Res, 2012, 10.1093/nar/gks306
Biochemical and molecular mechanisms of drug resistance in parasites, Ouellette, M., Trop Med Int Health, 2001
Inactivation of the Leishmania tarentolae pterin transporter (BT1) and reductase (PTR1) genes leads to viable parasites with changes in folate metabolism and hypersensitivity to the antifolate methotrexate, Ouellette, M., Roy, G., Kündig, C., El Fadili, A., J Biol Chem, 2004, 10.1074/jbc.M400652200
Intracellular localization of the ABCC proteins of Leishmania and their role in resistance to antimonials, Ouellette, M., Légaré, D., Leprohon, P., Antimicrob Agents Chemother, 2009, 10.1128/AAC.01474-08
Modulation of gene expression in Leishmania drug resistant mutants as determined by targeted DNA microarrays, Ouellette, M., Légaré, D., Bergeron, M. G., Corbeil, J., Papadopoulou, B., Messier, N., Richard, D., Briand, G., Peytavi, R., El Fadili, A., Marquis, N., Brochu, C., Trudel, N., Guimond, C., Nucleic Acids Res, 2003
Linear amplicons as precursors of amplified circles in methotrexate-resistant Leishmania tarentolae, Ouellette, M., Roy, G., Kündig, C., Grondin, K., Nucleic Acids Res, 1998
Modulation of gene expression in drug resistant Leishmania is associated with gene amplification, gene deletion and chromosome aneuploidy, Ouellette, M., Papadopoulou, B., Olivier, M., Tremblay, M. J., Corbeil, J., Rigault, P., Boisvert, S., Ouameur, A. A., Raymond, F., Légaré, D., Ubeda, J. M., Genome Biol, 2008, 10.1186/gb-2008-9-7-r115
Next Generation Vaccine Biomarkers workshop October 30-31, 2014--Ottawa, Canada, Richards, J. C., Barreto, L., Krishnan, L., Conlan, J. W., Raven, J. F., Ouellette, M., Spika, J., Fulton, K. M., Twine, S. M., Hum Vaccin Immunother, 2015, 10.1080/21645515.2015.1083663
Homologous recombination between direct repeat sequences yields P-glycoprotein containing amplicons in arsenite resistant Leishmania, Ouellette, M., Papadopoulou, B., Grondin, K., Nucleic Acids Res, 1993
Holistic understanding of trimethoprim resistance in Streptococcus pneumoniae using an integrative approach of genome-wide association study, resistance reconstruction, and machine learning, Marc Ouellette, Philippe Leprohon, Macha Nikolski, Alexis Groppi, Jie Feng, Chantal Godin, Hélène Gingras, Nguyen-Phuong Pham, mBio, 2024, 10.1128/mbio.01360-24
Co-amplification of the gamma-glutamylcysteine synthetase gene gsh1 and of the ABC transporter gene pgpA in arsenite-resistant Leishmania tarentolae, Ouellette, M., Rosen, B. P., Mukhopadhyay, R., Haimeur, A., Grondin, K., EMBO J, 1997, 10.1093/emboj/16.11.3057
Isolation and molecular characterization of beta-lactamase-producing Haemophilus parainfluenzae from the genital tract, Bergeron, M. G., Roy, P. H., Ouellette, M., Gosselin, P., Martel, A. Y., Antimicrob Agents Chemother, 1987
Comparative proteomics analyses reveal a potential biomarker for the detection of vancomycin-intermediate Staphylococcus aureus strains, Ouellette, M., Poirier, G. G., Bergeron, M. G., Winstall, E., Drummelsmith, J., J Proteome Res, 2007, 10.1021/pr070521m
Antimony uptake systems in the protozoan parasite Leishmania and accumulation differences in antimony-resistant parasites, Ouellette, M., Saravia, N. G., Wang, X. Y., Messier, N., Roy, G., Wang, J., Brochu, C., Antimicrob Agents Chemother, 2003
Leishmania major LmACR2 is a pentavalent antimony reductase that confers sensitivity to the drug pentostam, Mukhopadhyay, R., Rosen, B. P., Ouellette, M., Messier, N., Zhou, Y., J Biol Chem, 2004, 10.1074/jbc.M404383200
Gene amplification in Leishmania tarentolae selected for resistance to sodium stibogluconate, Ouellette, M., Haimeur, A., Antimicrob Agents Chemother, 1998
Functional cloning of the miltefosine transporter. A novel P-type phospholipid translocase from Leishmania involved in drug resistance, Castanys, S., Ouellette, M., Gamarro, F., Pérez-Victoria, F. J., J Biol Chem, 2003, 10.1074/jbc.M308352200
Structure of pteridine reductase (PTR1) from Leishmania tarentolae, Varughese, K. I., Whiteley, J. M., Matthews, D., Ferre, R. A., Zhao, M., Ouellette, M., Bray, T., Zhao, H., Acta Crystallogr D Biol Crystallogr, 2003
The Leishmania ATP-binding cassette protein PGPA is an intracellular metal-thiol transporter ATPase, Ouellette, M., Papadopoulou, B., Haimeur, A., Rosen, B. P., Stierhof, Y. D., Mukhopadhyay, R., Richard, D., Légaré, D., J Biol Chem, 2001, 10.1074/jbc.M102351200
Differential protein expression analysis of Leishmania major reveals novel roles for methionine adenosyltransferase and S-adenosylmethionine in methotrexate resistance, Ouellette, M., Trudel, N., Girard, I., Drummelsmith, J., J Biol Chem, 2004, 10.1074/jbc.M405183200
Drug uptake and modulation of drug resistance in Leishmania by an aquaglyceroporin, Mukhopadhyay, R., Rosen, B. P., Ouellette, M., Sundar, S., Legare, D., Bhattacharjee, H., Sonuc, N., Gourbal, B., J Biol Chem, 2004, 10.1074/jbc.M403959200
P-glycoprotein overexpression in methotrexate-resistant Leishmania tropica, Castanys, S., Ouellette, M., Légaré, D., Amador, M. V., Chiquero, M. J., Gamarro, F., Biochem Pharmacol, 1994
Nelfinavir, an HIV-1 protease inhibitor, induces oxidative stress-mediated, caspase-independent apoptosis in Leishmania amastigotes, Tremblay, M. J., Ouellette, M., Ouellet, M., Trudel, N., Lodge, R., Kumar, P., PLoS Negl Trop Dis, 2010, 10.1371/journal.pntd.0000642
[Studies on the parasite Leishmania in the post-genomic era], Papadopoulou, B., Sato, S., Olivier, M., Ouellette, M., Med Sci (Paris), 2003, 10.1051/medsci/20031910900
Nondegradable Antimicrobial Silver-Based Perovskite, Houshang Alamdari, Hossein Salimnia, Marc Ouellette, Fereshteh Fani, Cyrus Talebpour, ACS Sustainable Chemistry & Engineering, 2022, 10.1021/acssuschemeng.1c08181
Analysis by using DNA probes of the OXA-1 beta-lactamase gene and its transposon, Roy, P. H., Ouellette, M., Antimicrob Agents Chemother, 1986
Genome sequencing of linezolid-resistant Streptococcus pneumoniae mutants reveals novel mechanisms of resistance, Ouellette, M., Légaré, D., Dewar, K., Wasserscheid, J., Gingras, H., Lupien, A., Feng, J., Genome Res, 2009, 10.1101/gr.089342.108
The impact of distinct culture media in Leishmania infantum biology and infectivity, Cordeiro-DA-Silva, A., Ouellette, M., Moreira, D., Silva, C., Silvestre, R., Cunha, J., Santarém, N., Parasitology, 2014, 10.1017/S0031182013001388
Precise insertion of antibiotic resistance determinants into Tn21-like transposons: nucleotide sequence of the OXA-1 beta-lactamase gene, Roy, P. H., Bissonnette, L., Ouellette, M., Proc Natl Acad Sci U S A, 1987
Analysis of stage-specific expression of basic proteins in Leishmania infantum, Ouellette, M., Papadopoulou, B., Drummelsmith, J., Foucher, A. L., Racine, G., Brotherton, M. C., J Proteome Res, 2010, 10.1021/pr100048m
A genomic approach to understand interactions between Streptococcus pneumoniae and its bacteriophages, Ouellette, M., Moineau, S., Ouennane, S., Gingras, H., Leprohon, P., BMC Genomics, 2015, 10.1186/s12864-015-2134-8
Adaptation of Leishmania cells to in vitro culture results in a more efficient reduction and transport of biopterin, Ouellette, M., Papadopoulou, B., Olivier, M., Kündig, C., Roy, G., Exp Parasitol, 2001, 10.1006/expr.2001.4595
Thiol-induced reduction of antimony(V) into antimony(III): a comparative study with trypanothione, cysteinyl-glycine, cysteine and glutathione, Frézard, F., Ouellette, M., Brochu, C., Demicheli, C., Martins, P. S., Ferreira, C.os S, Biometals, 2003
ABC transporters involved in drug resistance in human parasites, Ouellette, M., Légaré, D., Leprohon, P., Essays Biochem, 2011, 10.1042/bse0500121
The gamma-glutamylcysteine synthetase gene of Leishmania is essential and involved in response to oxidants, Ouellette, M., Guimond, C., Roy, G., Mukherjee, A., Mol Microbiol, 2009, 10.1111/j.1365-2958.2009.06907.x
Genetic polymorphisms and drug susceptibility in four isolates of Leishmania tropica obtained from Canadian soldiers returning from Afghanistan, Ouellette, M., Rubinstein, E., Roy, G., Ruest, A., Ndao, M., Larios, O. E., Keynan, Y., Coelho, A., Plourde, M., PLoS Negl Trop Dis, 2012, 10.1371/journal.pntd.0001463
ABC proteins of Leishmania, Ouellette, M., Papadopoulou, B., Richard, D., Singh, A. K., Cayer, S., Légaré, D., J Bioenerg Biomembr, 2001
Point mutations in functionally diverse genes are associated with increased natural DNA transformation in multidrug resistant Streptococcus pneumoniae, Marc Ouellette, Philippe Leprohon, Jie Feng, Chantal Godin, Hélène Gingras, Nguyen Phuong Pham, Flora Peillard-Fiorente, Nucleic Acids Research, 2025, 10.1093/nar/gkae1140
Multiple mutations and increased RNA expression in tetracycline-resistant Streptococcus pneumoniae as determined by genome-wide DNA and mRNA sequencing, Ouellette, M., Leprohon, P., Bergeron, M. G., Gingras, H., Lupien, A., J Antimicrob Chemother, 2015, 10.1093/jac/dkv060
Parasite susceptibility to amphotericin B in failures of treatment for visceral leishmaniasis in patients coinfected with HIV type 1 and Leishmania infantum, Ouellette, M., Bastien, P., Leprohon, P., Plourde, M., Bourgeois, N., Lachaud, L., Clin Infect Dis, 2009, 10.1086/595710
Pterin and folate reduction by the Leishmania tarentolae H locus short-chain dehydrogenase/reductase PTR1, Ouellette, M., Lin, S. X., Whiteley, J. M., Bray, T., Papadopoulou, B., Leblanc, E., Chang, C. F., Wang, J., Arch Biochem Biophys, 1997, 10.1006/abbi.1997.0126
Gene disruption of the P-glycoprotein related gene pgpa of Leishmania tarentolae, Ouellette, M., Olivier, M., Rosen, B. P., Dey, S., Roy, G., Papadopoulou, B., Biochem Biophys Res Commun, 1996, 10.1006/bbrc.1996.1098
The promoter for a variant surface glycoprotein gene expression site in Trypanosoma brucei, Borst, P., Clayton, C. E., Bommer, A. M., Kieft, R., ten Asbroek, A. L., Ouellette, M., Zomerdijk, J. C., EMBO J, 1990
Drug resistance analysis by next generation sequencing in Leishmania, Ouellette, M., Monte-Neto, R., Gazanion, É, Fernandez-Prada, C., Leprohon, P., Int J Parasitol Drugs Drug Resist, 2015, 10.1016/j.ijpddr.2014.09.005
An ATP-dependent As(III)-glutathione transport system in membrane vesicles of Leishmania tarentolae, Rosen, B. P., Papadopoulou, B., Lightbody, J., Ouellette, M., Dey, S., Proc Natl Acad Sci U S A, 1996
ATP-binding cassette transporters: from multidrug resistance to genetic disease, Gosau, Austria, 20-27 February 1999, Rosen, B. P., Ouellette, M., Dey, S., Drug Resist Updat, 1999, 10.1054/drup.1999.0072
Characterization of a plasmid isolated from Branhamella catarrhalis and detection of plasmid sequences within the genome of a B. catarrhalis strain, Roy, P. H., Bergeron, M. G., Ouellette, M., Beaulieu, D., Plasmid, 1988
Unresponsiveness to Glucantime treatment in Iranian cutaneous leishmaniasis due to drug-resistant Leishmania tropica parasites, Ouellette, M., Khamesipour, A., Hajjaran, H., Boucher, P., Mohebali, M., Hadighi, R., PLoS Med, 2006, 10.1371/journal.pmed.0030162
Whole-genome comparative RNA expression profiling of axenic and intracellular amastigote forms of Leishmania infantum, Papadopoulou, B., Ouellette, M., Corbeil, J., Raymond, F., Rochette, A., Mol Biochem Parasitol, 2009, 10.1016/j.molbiopara.2008.12.012
Formation of linear amplicons with inverted duplications in Leishmania requires the MRE11 nuclease, Ouellette, M., Masson, J. Y., Légaré, D., Mukherjee, A., Genois, M. M., Laffitte, M. C., PLoS Genet, 2014, 10.1371/journal.pgen.1004805
High affinity S-Adenosylmethionine plasma membrane transporter of Leishmania is a member of the folate biopterin transporter (FBT) family, Ouellette, M., Ahmed Ouameur, A., Dridi, L., J Biol Chem, 2010, 10.1074/jbc.M110.114520
The amplified H circle of methotrexate-resistant leishmania tarentolae contains a novel P-glycoprotein gene, Borst, P., Fase-Fowler, F., Ouellette, M., EMBO J, 1990
Roles of Rad51 paralogs for promoting homologous recombination in Leishmania infantum, Masson, J. Y., Ouellette, M., Poirier, G. G., Roy, G., Éthier, C., Plourde, M., Genois, M. M., Nucleic Acids Res, 2015, 10.1093/nar/gkv118
Genetic, biochemical and molecular characterization of strains of Vibrio cholerae multiresistant to antibiotics, Courvalin, P., Gerbaud, G., Ouellette, M., Ann Inst Pasteur Microbiol, 1988
Targeted insertion of the neomycin phosphotransferase gene into the tubulin gene cluster of Trypanosoma brucei, Borst, P., Ouellette, M., ten Asbroek, A. L., Nature, 1990, 10.1038/348174a0
Development of a PCR assay for rapid detection of enterococci, Bergeron, M. G., Ouellette, M., Roy, P. H., Ménard, C., Martineau, F., Picard, F. J., Ke, D., J Clin Microbiol, 1999
Leishmaniasis: drugs in the clinic, resistance and new developments, Papadopoulou, B., Drummelsmith, J., Ouellette, M., Drug Resist Updat, 2004, 10.1016/j.drup.2004.07.002
Prefractionation by digitonin extraction increases representation of the cytosolic and intracellular proteome of Leishmania infantum, Ouellette, M., Papadopoulou, B., Foucher, A. L., J Proteome Res, 2006, 10.1021/pr060081j
Intracellular survival of Leishmania species that cause visceral leishmaniasis is significantly reduced by HIV-1 protease inhibitors, Tremblay, M. J., Ouellette, M., Sundar, S., Messier, N., Garg, R., Trudel, N., J Infect Dis, 2008, 10.1086/592280
Coordinating funding in public health emergencies, GloPID-R members, Ouellette, M., Mphahlele, J., Hwang, E. S., Delfraissy, J. F., Colli, W., Matthiessen, L., Lancet, 2016, 10.1016/S0140-6736(16)30604-3
Growth phase regulation of the main folate transporter of Leishmania infantum and its role in methotrexate resistance, Ouellette, M., Drummelsmith, J., Leprohon, P., Richard, D., J Biol Chem, 2004, 10.1074/jbc.M409264200
Separation of basic proteins from Leishmania using a combination of Free flow electrophoresis (FFE) and 2D electrophoresis (2-DE) under basic conditions, Ouellette, M., Racine, G., Brotherton, M. C., Methods Mol Biol, 2015, 10.1007/978-1-4939-1438-8_15
Binding of Mycoplasma arthritidis-derived mitogen to human MHC class II molecules via its N terminus is modulated by invariant chain expression and its C terminus is required for T cell activation, Mourad, W., Ouellette, M., Etongué-Mayer, P., Langlois, M. A., Eur J Immunol, 2000, 10.1002/1521-4141(200006)30:6<1748::AID-IMMU1748>3.0.CO;2-J
New mechanisms of drug resistance in parasitic protozoa, Ouellette, M., Borst, P., Annu Rev Microbiol, 1995, 10.1146/annurev.mi.49.100195.002235
Use of phylogenetical analysis to predict susceptibility of pathogenic Candida spp. to antifungal drugs, Bergeron, M. G., Roy, P. H., Ouellette, M., Boily, M. J., Trépanier, H., Picard, F. J., Boudreau, D. K., Pelletier, R., Boissinot, M., Piché, Y., Sellam, A., Maheux, A. F., J Microbiol Methods, 2016, 10.1016/j.mimet.2016.09.020
Role of the locus and of the resistance gene on gene amplification frequency in methotrexate resistant Leishmania tarentolae, Ouellette, M., Papadopoulou, B., Leblanc, E., Kündig, C., Nucleic Acids Res, 1999
Acquisition by a Campylobacter-like strain of aphA-1, a kanamycin resistance determinant from members of the family Enterobacteriaceae, Courvalin, P., Lambert, T., Gerbaud, G., Ouellette, M., Antimicrob Agents Chemother, 1987
Use of tuf sequences for genus-specific PCR detection and phylogenetic analysis of 28 streptococcal species, Bergeron, M. G., Roy, P. H., Ouellette, M., Richard, D., Huletsky, A., Boissinot, M., Boudreau, D. K., Ke, D., Picard, F. J., J Clin Microbiol, 2004, 10.1128/JCM.42.8.3686-3695.2004
Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania, Rosen, B. P., Ouellette, M., Lightbody, J., Gage, D., Xu, N., Dey, S., Mukhopadhyay, R., Proc Natl Acad Sci U S A, 1996
Direct and inverted DNA repeats associated with P-glycoprotein gene amplification in drug resistant Leishmania, Borst, P., Fase-Fowler, F., Wüst, D., Hettema, E., Ouellette, M., EMBO J, 1991
Identification of developmentally-regulated proteins in Leishmania panamensis by proteome profiling of promastigotes and axenic amastigotes, Ouellette, M., Girard, I., Burchmore, R., Drummelsmith, J., Gomez, M. A., Vasquez, J. J., Walker, J., Mol Biochem Parasitol, 2006, 10.1016/j.molbiopara.2006.01.008
Role of ABC transporter MRPA, gamma-glutamylcysteine synthetase and ornithine decarboxylase in natural antimony-resistant isolates of Leishmania donovani, Madhubala, R., Ouellette, M., Chatterjee, M., Girard, I., Roy, G., Singh, S., Padmanabhan, P. K., Mukherjee, A., J Antimicrob Chemother, 2007, 10.1093/jac/dkl494
A proteomics screen implicates HSP83 and a small kinetoplastid calpain-related protein in drug resistance in Leishmania donovani clinical field isolates by modulating drug-induced programmed cell death, Ouellette, M., Drummelsmith, J., Sundar, S., Girard, I., Gourbal, B., Vergnes, B., Mol Cell Proteomics, 2007, 10.1074/mcp.M600319-MCP200
Untargeted metabolomic analysis of miltefosine action in Leishmania infantum reveals changes to the internal lipid metabolism, Ouellette, M., Smith, T. K., Burgess, K., Rivas, L., Weidt, S., Vincent, I. M., Int J Parasitol Drugs Drug Resist, 2014, 10.1016/j.ijpddr.2013.11.002
DNA repair pathways in trypanosomatids: from DNA repair to drug resistance, Masson, J. Y., Ouellette, M., Rodrigue, A., Maity, R., Laffitte, M. C., Paquet, E. R., Genois, M. M., Microbiol Mol Biol Rev, 2014, 10.1128/MMBR.00045-13
Frequent amplification of a short chain dehydrogenase gene in methotrexate resistant Leishmania, Ouellette, M., Papadopoulou, B., Adv Exp Med Biol, 1993
Characterization of the folylpolyglutamate synthetase gene and polyglutamylation of folates in the protozoan parasite Leishmania, Ouellette, M., Kündig, C., El Fadili, A., Mol Biochem Parasitol, 2002
Modulation of Leishmania ABC protein gene expression through life stages and among drug-resistant parasites, Ouellette, M., Papadopoulou, B., Girard, I., Légaré, D., Leprohon, P., Eukaryot Cell, 2006, 10.1128/EC.00152-06
Genome-wide gene expression profiling analysis of Leishmania major and Leishmania infantum developmental stages reveals substantial differences between the two species, Papadopoulou, B., Ouellette, M., Corbeil, J., Rigault, P., Boisvert, S., Messier, N., Smith, M., Ubeda, J. M., Raymond, F., Rochette, A., BMC Genomics, 2008, 10.1186/1471-2164-9-255
A proteomic approach to identify developmentally regulated proteins in Leishmania infantum, Papadopoulou, B., Ouellette, M., El Fakhry, Y., Proteomics, 2002, 10.1002/1615-9861(200208)2:8<1007::AID-PROT1007>3.0.CO;2-G
A combined proteomic and transcriptomic approach to the study of stage differentiation in Leishmania infantum, Papadopoulou, B., Ouellette, M., Boilard, N., Madore, E., Müller, M., Drummelsmith, J., McNicoll, F., Proteomics, 2006, 10.1002/pmic.200500853
Use of oral miltefosine for cutaneous leishmaniasis in Canadian soldiers returning from Afghanistan, Rubinstein, E., Ouellette, M., Plourde, M., Wiseman, M. C., Larios, O. E., Keynan, Y., Can J Infect Dis Med Microbiol, 2008
A new type of high affinity folic acid transporter in the protozoan parasite Leishmania and deletion of its gene in methotrexate-resistant cells, Ouellette, M., Kündig, C., Richard, D., J Biol Chem, 2002, 10.1074/jbc.M204796200
Inhibition of MRSA and of Clostridium difficile by durancin 61A: synergy with bacteriocins and antibiotics, Fliss, I., Ouellette, M., Ben Hamida, J., Bergeron, M. G., Kourda, R., Gingras, H., Hammami, R., Hanchi, H., Future Microbiol, 2017, 10.2217/fmb-2016-0113
Resistance to antimony and treatment failure in human Leishmania (Viannia) infection, Saravia, N. G., Ouellette, M., Varona, M. X., Valderrama, M., Valderrama, L., Rojas, R., J Infect Dis, 2006, 10.1086/503371
Coordinated gene expression by post-transcriptional regulons in African trypanosomes, Papadopoulou, B., Ouellette, M., J Biol, 2009, 10.1186/jbiol203
Functional analysis and complex gene rearrangements of the folate/biopterin transporter (FBT) gene family in the protozoan parasite Leishmania, Ouellette, M., Légaré, D., Girard, I., Ouameur, A. A., Mol Biochem Parasitol, 2008, 10.1016/j.molbiopara.2008.08.007
Different Mutations in a P-type ATPase Transporter in Leishmania Parasites are Associated with Cross-resistance to Two Leading Drugs by Distinct Mechanisms, Ouellette, M., Smith, T. K., Leprohon, P., Rivas, L., Roy, G., Roberts, M., Brotherton, M. C., Vincent, I. M., Fernandez-Prada, C., PLoS Negl Trop Dis, 2016, 10.1371/journal.pntd.0005171
Control of surface antigen genes in African trypanosomes, Zomerdijk, J. C., ten Asbroek, A. L., Ouellette, M., Lutgerink, J., Gommers-Ampt, J. H., Borst, P., Biochem Soc Trans, 1990
Gene expression modulation is associated with gene amplification, supernumerary chromosomes and chromosome loss in antimony-resistant Leishmania infantum, Ouellette, M., Corbeil, J., Hardiman, G., Madore, E., Raymond, F., Légaré, D., Leprohon, P., Nucleic Acids Res, 2009, 10.1093/nar/gkn1069
Discovery of factors linked to antimony resistance in Leishmania panamensis through differential proteome analysis, Saravia, N. G., Gomez, M. A., Ouellette, M., Roy, G., Burchmore, R., Drummelsmith, J., Vasquez, J. J., Gongora, R., Walker, J., Mol Biochem Parasitol, 2012, 10.1016/j.molbiopara.2012.03.002
The heat shock protein HSP70 and heat shock cognate protein HSC70 contribute to antimony tolerance in the protozoan parasite leishmania, Ouellette, M., Haimeur, A., Brochu, C., Cell Stress Chaperones, 2004
Preventing antibiotic resistance using rapid DNA-based diagnostic tests, Ouellette, M., Bergeron, M. G., Infect Control Hosp Epidemiol, 1998
Microbial multidrug-resistance ABC transporters, Papadopoulou, B., Légaré, D., Ouellette, M., Trends Microbiol, 1994
Drug resistance and P-glycoprotein gene amplification in the protozoan parasite Leishmania, Borst, P., Ouellette, M., Res Microbiol, 1991
Preventing antibiotic resistance through rapid genotypic identification of bacteria and of their antibiotic resistance genes in the clinical microbiology laboratory, Ouellette, M., Bergeron, M. G., J Clin Microbiol, 1998
Divergence among genes encoding the elongation factor Tu of Yersinia Species, Bergeron, M. G., Ouellette, M., Roy, P. H., Bryden, L., Mulvey, M. R., Bader, D. E., Chain, P. S., Parham, N. J., Martel, E. A., Picard, F. J., Grondin, M., Boudreau, D. K., Boissinot, M., Leblanc, E., Isabel, S., J Bacteriol, 2008, 10.1128/JB.01067-08
Genome annotation and intraviral interactome for the Streptococcus pneumoniae virulent phage Dp-1, Moineau, S., Uetz, P., Titz, B., García, E., Moeck, G., Dehbi, M., Liu, J., Ouellette, M., Häuser, R., Sabri, M., J Bacteriol, 2011, 10.1128/JB.01117-10
Evidence for horizontal gene transfer in evolution of elongation factor Tu in enterococci, Bergeron, M. G., Roy, P. H., Ouellette, M., Frenette, J., Picard, F. J., Huletsky, A., Ke, D., Boissinot, M., J Bacteriol, 2000
Stage specific gene expression and cellular localization of two isoforms of the serine hydroxymethyltransferase in the protozoan parasite Leishmania, Ouellette, M., Girard, I., Foucher, A., Gagnon, D., Mol Biochem Parasitol, 2006, 10.1016/j.molbiopara.2006.06.009
Modulation in aquaglyceroporin AQP1 gene transcript levels in drug-resistant Leishmania, Ouellette, M., Mukhopadhyay, R., Rosen, B. P., Gourbal, B., Marquis, N., Mol Microbiol, 2005, 10.1111/j.1365-2958.2005.04782.x
Development of a rapid PCR assay specific for Staphylococcus saprophyticus and application to direct detection from urine samples, Bergeron, M. G., Ouellette, M., Roy, P. H., Ménard, C., Picard, F. J., Martineau, F., J Clin Microbiol, 2000
Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages, Papadopoulou, B., Olivier, M., Tamar, S., Fairlamb, A. H., Cunningham, M. L., Tovar, J., Ouellette, M., Dumas, C., EMBO J, 1997, 10.1093/emboj/16.10.2590
Exoproteome dynamics in Leishmania infantum, Ouellette, M., Cordeiro-da-Silva, A., Silvestre, R., Racine, G., Santarém, N., J Proteomics, 2013, 10.1016/j.jprot.2013.03.012
Generation of an aquaglyceroporin AQP1 null mutant in Leishmania major, Ouellette, M., Mukhopadhyay, R., Monte-Neto, R. L., Mandal, G., Ubeda, J. M., Plourde, M., Mol Biochem Parasitol, 2015, 10.1016/j.molbiopara.2015.07.003
Plasticity of the Leishmania genome leading to gene copy number variations and drug resistance, Ouellette, M., Papadopoulou, B., Leprohon, P., Laffitte, M. N., F1000Res, 2016, 10.12688/f1000research.9218.1
Correlation between the resistance genotype determined by multiplex PCR assays and the antibiotic susceptibility patterns of Staphylococcus aureus and Staphylococcus epidermidis, Bergeron, M. G., Ouellette, M., Roy, P. H., Ménard, C., Lansac, N., Picard, F. J., Martineau, F., Antimicrob Agents Chemother, 2000
Exploring the genetic basis of natural resistance to microcins, Ismaïl Fliss, Séverine Zirah, Marc Ouellette, Sylvie Rebuffat, Laila Ben Said, Nguyen Phuong Pham, Soufiane Telhig, Microbial Genomics, 2024, 10.1099/mgen.0.001156
Rapid detection of group B streptococci in pregnant women at delivery, Fraser, W. D., Marcoux, S., Roy, P. H., Ouellette, M., Bernier, M., Gagnon, M., Picard, F. J., Ménard, C., Ke, D., Bergeron, M. G., N Engl J Med, 2000, 10.1056/NEJM200007203430303
The role of reduced pterins in resistance to reactive oxygen and nitrogen intermediates in the protozoan parasite Leishmania, Ouellette, M., Leblanc, E., Moreira, W., Free Radic Biol Med, 2009, 10.1016/j.freeradbiomed.2008.10.034
Inactivation of the cytosolic and mitochondrial serine hydroxymethyl transferase genes in Leishmania major, Ouellette, M., Roy, G., Mol Biochem Parasitol, 2015, 10.1016/j.molbiopara.2016.02.003
Real-time PCR assay for detection of fluoroquinolone resistance associated with grlA mutations in Staphylococcus aureus, Bergeron, M. G., Ouellette, M., Roy, P. H., Picard, F. J., Fortin, V., Huletsky, A., Lapierre, P., J Clin Microbiol, 2003
Oligonucleotide probes for the detection of TEM-1 and TEM-2 beta-lactamase genes and their transposons, Roy, P. H., Bazin, R., Rossi, J. J., Ouellette, M., Can J Microbiol, 1987
Microfluidic device for rapid (<15 min) automated microarray hybridization, Bergeron, M. G., Ouellette, M., Bissonnette, L., Boissinot, M., Boissinot, K., Madou, M., Zoval, J., Jia, G., Picard, F. J., Gagné, D., Raymond, F. R., Peytavi, R., Clin Chem, 2005, 10.1373/clinchem.2005.052845
Frequent amplification of a short chain dehydrogenase gene as part of circular and linear amplicons in methotrexate resistant Leishmania, Ouellette, M., Roy, G., Papadopoulou, B., Nucleic Acids Res, 1993
Changes in folate and pterin metabolism after disruption of the Leishmania H locus short chain dehydrogenase gene, Ouellette, M., Leblanc, E., Mourad, W., Roy, G., Papadopoulou, B., J Biol Chem, 1994
Pterin transport and metabolism in Leishmania and related trypanosomatid parasites, Roy, G., Richard, D., Kündig, C., El-Fadili, A., Drummelsmith, J., Ouellette, M., Int J Parasitol, 2002
Autonomous replication of bacterial DNA plasmid oligomers in Leishmania, Ouellette, M., Roy, G., Papadopoulou, B., Mol Biochem Parasitol, 1994
A novel antifolate resistance gene on the amplified H circle of Leishmania, Ouellette, M., Roy, G., Papadopoulou, B., EMBO J, 1992
Development of conventional and real-time PCR assays for the rapid detection of group B streptococci, Bergeron, M. G., Roy, P. H., Ouellette, M., Boissinot, M., Picard, F. J., Ménard, C., Ke, D., Clin Chem, 2000
Genomic characterization of ciprofloxacin resistance in a laboratory-derived mutant and a clinical isolate of Streptococcus pneumoniae, Ouellette, M., Leprohon, P., Zhanel, G. G., Soualhine, H., Fani, F., Billal, D. S., Lupien, A., Antimicrob Agents Chemother, 2013, 10.1128/AAC.00418-13
Protection against Leishmania major challenge infection in mice vaccinated with live recombinant parasites expressing a cytotoxic gene, Papadopoulou, B., Ouellette, M., Bergeron, M. G., Harvie, P., Olivier, M., Muyombwe, A., J Infect Dis, 1998
In primary human monocyte-derived macrophages exposed to Human immunodeficiency virus type 1, does the increased intracellular growth of Leishmania infantum rely on its enhanced uptake?, Tremblay, M. J., Papadopoulou, B., Ouellette, M., Messier, N., Thibault, S., Zhao, C., J Gen Virol, 2006, 10.1099/vir.0.81647-0
Species-specific and ubiquitous DNA-based assays for rapid identification of Staphylococcus epidermidis, Bergeron, M. G., Ouellette, M., Roy, P. H., Picard, F. J., Martineau, F., J Clin Microbiol, 1996
The initial state of the human gut microbiome determines its reshaping by antibiotics, Corbeil, J., Bergeron, M. G., Ouellette, M., Roy, P. H., Huletsky, A., Boissinot, M., Trottier, S., Domingo, M. C., Chabot, I., Simard, J. L., Boudreau, D. K., Frenette, J., Bérubé, È, Giroux, R., Plante, P. L., Leprohon, P., Dridi, B., Gingras, H., Iqbal, N., Déraspe, M., Ouameur, A. A., Raymond, F., ISME J, 2016, 10.1038/ismej.2015.148
Whole genome sequencing of penicillin-resistant Streptococcus pneumoniae reveals mutations in penicillin-binding proteins and in a putative iron permease, Ouellette, M., Légaré, D., Leprohon, P., Fani, F., Genome Biol, 2011, 10.1186/gb-2011-12-11-r115
Intrachromosomal tandem duplication and repeat expansion during attempts to inactivate the subtelomeric essential gene GSH1 in Leishmania, Ouellette, M., Langston, L. D., Mukherjee, A., Nucleic Acids Res, 2011, 10.1093/nar/gkr494
New Resistance Mutations Linked to Decreased Susceptibility to Solithromycin in Streptococcus pneumoniae Revealed by Chemogenomic Screens, Marc Ouellette, Philippe Leprohon, Kevin Patron, Chantal Godin, Flora Peillard-Fiorente, Hélène Gingras, Antimicrobial Agents and Chemotherapy, 2023, 10.1128/aac.00395-23
Formation of extrachromosomal circular amplicons with direct or inverted duplications in drug-resistant Leishmania tarentolae, Ouellette, M., Roy, G., Grondin, K., Mol Cell Biol, 1996
Proteomic and transcriptomic analysis of linezolid resistance in Streptococcus pneumoniae, Ouellette, M., Leprohon, P., Légaré, D., Winstall, E., Racine, G., Lupien, A., Billal, D. S., Feng, J., J Proteome Res, 2011, 10.1021/pr200221s
Elevated levels of polyamines and trypanothione resulting from overexpression of the ornithine decarboxylase gene in arsenite-resistant Leishmania, Ouellette, M., Poulin, R., Rosen, B. P., Mukhopadhyay, R., Pilote, S., Guimond, C., Haimeur, A., Mol Microbiol, 1999
Gene expression modulation and the molecular mechanisms involved in Nelfinavir resistance in Leishmania donovani axenic amastigotes, Tremblay, M. J., Ouellette, M., Corbeil, J., Jalaguier, P., Ritt, J. F., Raymond, F., Lodge, R., Kumar, P., Mol Microbiol, 2013, 10.1111/mmi.12298
Proteomic and genomic analyses of antimony resistant Leishmania infantum mutant, Ouellette, M., Droit, A., Poirier, G. G., Légaré, D., Leprohon, P., Bourassa, S., Brotherton, M. C., PLoS One, 2013, 10.1371/journal.pone.0081899
Homology of ORFs from Tn2603 and from R46 to site-specific recombinases, Roy, P. H., Ouellette, M., Nucleic Acids Res, 1987
Involvement of Dcr1 in post-transcriptional regulation of gene expression in Schizosaccharomyces pombe, Provost, P., Ouellette, M., Rohani, M., Plante, P., Gobeil, L. A., Front Biosci, 2008
Telomeric gene deletion and intrachromosomal amplification in antimony-resistant Leishmania, Ouellette, M., Corbeil, J., Mukhopadhyay, R., Raymond, F., Coelho, A. C., Monte-Neto, R. L., Boisvert, S., Mukherjee, A., Mol Microbiol, 2013, 10.1111/mmi.12178
Structure-function analysis of the highly conserved charged residues of the membrane protein FT1, the main folic acid transporter of the protozoan parasite Leishmania, Ouellette, M., Haimeur, A., Dridi, L., Biochem Pharmacol, 2010, 10.1016/j.bcp.2009.07.019
Phylogeny of the Enterobacteriaceae based on genes encoding elongation factor Tu and F-ATPase beta-subunit, Bergeron, M. G., Roy, P. H., Ouellette, M., Picard, F. J., Boudreau, D. K., Martel, E. A., Bélanger, S. D., Paquette, N., Boissinot, M., Paradis, S., Int J Syst Evol Microbiol, 2005, 10.1099/ijs.0.63539-0
Species-specific and ubiquitous-DNA-based assays for rapid identification of Staphylococcus aureus, Bergeron, M. G., Ouellette, M., Roy, P. H., Picard, F. J., Martineau, F., J Clin Microbiol, 1998
HIV-1 replication is stimulated by sodium stibogluconate, the therapeutic mainstay in the treatment of leishmaniasis, Tremblay, M. J., Ouellette, M., Zhao, C., Barat, C., J Infect Dis, 2007, 10.1086/510398
Efflux systems and increased trypanothione levels in arsenite-resistant Leishmania, Ouellette, M., Rosen, B. P., Brochu, C., Grondin, K., Dey, S., Haimeur, A., Mukhopadhyay, R., Roy, G., Papadopoulou, B., Légaré, D., Exp Parasitol, 1997, 10.1006/expr.1997.4222
Multidrug resistance and ABC transporters in parasitic protozoa, Papadopoulou, B., Légaré, D., Ouellette, M., J Mol Microbiol Biotechnol, 2001
Induced tigecycline resistance in Streptococcus pneumoniae mutants reveals mutations in ribosomal proteins and rRNA, Ouellette, M., Leprohon, P., Gingras, H., Lupien, A., J Antimicrob Chemother, 2015, 10.1093/jac/dkv211
Nisin is an effective inhibitor of Clostridium difficile vegetative cells and spore germination, Fliss, I. L., Ouellette, M., Bergeron, M. G., Dridi, L., Le Lay, C., J Med Microbiol, 2016, 10.1099/jmm.0.000202
Episomal and stable expression of the luciferase reporter gene for quantifying Leishmania spp. infections in macrophages and in animal models, Papadopoulou, B., Olivier, M., Ouellette, M., Tremblay, M. J., Singh, A. K., Wu, Y., Sereno, D., Dumas, C., Roy, G., Mol Biochem Parasitol, 2000
Role of the ABC transporter PRP1 (ABCC7) in pentamidine resistance in Leishmania amastigotes, Cotrim, P. C., Ouellette, M., Messier, N., Coelho, A. C., Antimicrob Agents Chemother, 2007, 10.1128/AAC.00404-07
Combined gene deletion of dihydrofolate reductase-thymidylate synthase and pteridine reductase in Leishmania infantum, Marc Ouellette, Philippe Leprohon, Arijit Bhattacharya, PLOS Neglected Tropical Diseases, 2021, 10.1371/journal.pntd.0009377
Oligonucleotide probes (TEM-1, OXA-1) versus isoelectric focusing in beta-lactamase characterization of 114 resistant strains, Roy, P. H., Philippon, A. M., Paul, G. C., Ouellette, M., Antimicrob Agents Chemother, 1988
DNA transformation of Leishmania infantum axenic amastigotes and their use in drug screening, Ouellette, M., Papadopoulou, B., Lemesre, J. L., Roy, G., Sereno, D., Antimicrob Agents Chemother, 2001, 10.1128/AAC.45.4.1168-1173.2001
Cos-Seq for high-throughput identification of drug target and resistance mechanisms in the protozoan parasite Leishmania, Ouellette, M., Leprohon, P., Papadopoulou, B., Fernández-Prada, C., Gazanion, É, Proc Natl Acad Sci U S A, 2016, 10.1073/pnas.1520693113
Quantitative proteomic analysis of amphotericin B resistance in Leishmania infantum, Ouellette, M., Droit, A., Poirier, G. G., Légaré, D., Bourassa, S., Brotherton, M. C., Int J Parasitol Drugs Drug Resist, 2014, 10.1016/j.ijpddr.2014.05.002
Gene amplification and point mutations in pyrimidine metabolic genes in 5-fluorouracil resistant Leishmania infantum, Ouellette, M., Corbeil, J., Légaré, D., Leprohon, P., Raymond, F., Ritt, J. F., PLoS Negl Trop Dis, 2013, 10.1371/journal.pntd.0002564
Biochemical characterization of Leishmania major aquaglyceroporin LmAQP1: possible role in volume regulation and osmotaxis, Mukhopadhyay, R., Bhattacharjee, H., Ouellette, M., LeFurgey, A., Zhou, Y., Uzcategui, N. L., Figarella, K., Mol Microbiol, 2007, 10.1111/j.1365-2958.2007.05845.x
The Canadian Institutes of Health Research Institute of Infection and Immunity response to the threat of antimicrobial resistance, Ouellette, M., Raven, J. F., Rev Panam Salud Publica, 2011
Proteome mapping of the protozoan parasite Leishmania and application to the study of drug targets and resistance mechanisms, Ouellette, M., Messier, N., Girard, I., Brochu, V., Drummelsmith, J., Mol Cell Proteomics, 2003, 10.1074/mcp.M200085-MCP200
A natural mutation of the amino acid residue at position 60 destroys staphylococcal enterotoxin A murine T-cell mitogenicity, Mourad, W., Ouellette, M., Hébert, J., Valet, J. P., Lévéillé, C., al-Daccak, R., Mahana, W., Infect Immun, 1995
Role of the ABC transporter MRPA (PGPA) in antimony resistance in Leishmania infantum axenic and intracellular amastigotes, Ouellette, M., Légaré, D., Papadopoulou, B., Saravia, N. G., Trudel, N., Guimond, C., Roy, G., Leprohon, P., Messier, N., El Fadili, K., Antimicrob Agents Chemother, 2005, 10.1128/AAC.49.5.1988-1993.2005
Increased transport of pteridines compensates for mutations in the high affinity folate transporter and contributes to methotrexate resistance in the protozoan parasite Leishmania tarentolae, Ouellette, M., Papadopoulou, B., Légaré, D., Haimeur, A., Kündig, C., EMBO J, 1999, 10.1093/emboj/18.9.2342
Contribution of the Leishmania P-glycoprotein-related gene ltpgpA to oxyanion resistance, Ouellette, M., Rosen, B. P., Dey, S., Roy, G., Papadopoulou, B., J Biol Chem, 1994

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Anwesha Bandyopadhyay - Post-doctorat - En cours
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