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Luc Vallières

Professeur titulaire

Luc Vallières
luc.vallieres@fmed.ulaval.ca
Centre thématique de recherche en neurosciences
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Immunologie-infectiologie
Neurosciences et santé mentale

Domaines et intérêts de recherche du (de la) professeur(e) :

Maladies infectieuses et immunitaires
  • Maladies auto-immunes
  • Maladies du système immunitaire
  • Leucocytes
  • Thérapie cellulaire des maladies infectieuses et immunitaires
  • Immunothérapie
  • Système immunitaire
Neurosciences, santé mentale et toxicomanies
  • Sclérose en plaques
  • Maladies neuroimmunologiques
  • Maladies inflammatoires du système nerveux central
  • Maladies neurodégénératives
  • Maladies neurologiques

Projets de recherche

  • Autoantibodies and antibody-producing cells in neurological autoimmune diseases: from biology to therapeutic targeting - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2023-10-01 au 2028-09-30
  • endMS National Education and Training Program: Summer School and SPRINT - Société canadienne de la sclérose en plaques - endMS National Training Program, McGill University, co-chercheur - 2023-06-15 au 2026-06-14
  • Mécanisme d’action d’ASPRV1 dans l’inflammation - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2021-04-01 au 2026-03-31
  • Dual function of autoantibodies in a model of multiple sclerosis - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2023-03-01 au 2024-02-29
  • Plate-forme de production de nanoparticules lipidiques pour le développement de thérapies à base d'acides nucléiques - Ministère de la Santé et des Services sociaux, Fondation Canadienne pour l'innovation (La) - Fonds des leaders John-R.-Evans (FLJR), chercheur principal - 2022-03-22 au 2023-09-28
  • 16th Congress of the International Society of Neuroimmunology (ISNI 2023) - Instituts de recherche en santé du Canada - Subventions de planification et dissémination – Programme d’appui communautaire des instituts, chercheur principal - 2022-06-01 au 2023-05-31
  • Suppression of regulatory B cells by neutrophils in a model of multiple sclerosis - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2018-10-01 au 2023-03-31

Publications

  • Increased glioma growth in mice depleted of macrophages., , Cancer research, 2007, 10.1158/0008-5472.can-07-0177
  • Selective involvement of interleukin-6 in the transcriptional activation of the suppressor of cytokine signaling-3 in the brain during systemic immune challenges., , Endocrinology, 2000, 10.1210/endo.141.10.7695
  • The rat growth hormone proximal silencer contains a novel DNA-binding site for multiple nuclear proteins that represses basal promoter activity., , European journal of biochemistry, 1994, 10.1111/j.1432-1033.1994.00419.x
  • C-fos mRNA pattern and corticotropin-releasing factor neuronal activity throughout the brain of rats injected centrally with a prostaglandin of E2 type., , Journal of neuroimmunology, 1996, 10.1016/s0165-5728(96)00114-2
  • Transcriptome analysis of myeloid cells (neutrophils, macrophages and dendritic cells) isolated from the spinal cord of mice with experimental autoimmune encephalomyelitis (EAE), , 2017
  • Rod-Shaped monocytes patrol the brain vasculature and give rise to perivascular macrophages under the influence of proinflammatory cytokines and angiopoietin-2., , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, 10.1523/jneurosci.3510-08.2008
  • ASPRV1 as a neutrophil-specific marker and therapeutic target for inflammatory diseases, , 2017
  • Optimization of a lipid nanoparticle–based protocol for RNA transfection into primary mononuclear phagocytes, Luc Vallières, Sébastien S Hébert, Nicolas Bertrand, Sabrina Roussel, Louis-Charles Béland, Yu Zhang, Journal of Leukocyte Biology, 2024, 10.1093/jleuko/qiae059
  • Identification of genes preferentially expressed by microglia and upregulated during cuprizone-induced inflammation., , Glia, 2007, 10.1002/glia.20477
  • Tumor necrosis factor reduces brain tumor growth by enhancing macrophage recruitment and microcyst formation., , Cancer research, 2005, 10.1158/0008-5472.can-04-3612
  • GPR84 deficiency reduces microgliosis, but accelerates dendritic degeneration and cognitive decline in a mouse model of Alzheimer's disease., , Brain, behavior, and immunity, 2015, 10.1016/j.bbi.2015.01.010
  • Transplanted bone marrow cells do not provide new oocytes but rescue fertility in female mice following treatment with chemotherapeutic agents., , Cellular reprogramming, 2012, 10.1089/cell.2011.0066
  • G protein-coupled receptor 84, a microglia-associated protein expressed in neuroinflammatory conditions., , Glia, 2007, 10.1002/glia.20506
  • Dark microglia: A new phenotype predominantly associated with pathological states., , Glia, 2016, 10.1002/glia.22966
  • Regulation of the genes encoding interleukin-6, its receptor, and gp130 in the rat brain in response to the immune activator lipopolysaccharide and the proinflammatory cytokine interleukin-1beta., , Journal of neurochemistry, 1997
  • Reduced glioma growth following dexamethasone or anti-angiopoietin 2 treatment., , Brain pathology (Zurich, Switzerland), 2008, 10.1111/j.1750-3639.2008.00139.x
  • Expression of the alpha4 integrin subunit gene promoter is modulated by the transcription factor Pax-6 in corneal epithelial cells., , Investigative ophthalmology & visual science, 2004, 10.1167/iovs.03-0908
  • Rapid externalization of 27-kDa heat shock protein (HSP27) and atypical cell death in neutrophils treated with the sphingolipid analog drug FTY720., , Journal of leukocyte biology, 2015, 10.1189/jlb.3vma1114-522rr
  • E-MTAB-6160 - Transcriptome analysis of myeloid cells (neutrophils, macrophages and dendritic cells) isolated from the spinal cord of mice with experimental autoimmune encephalomyelitis (EAE), , 2017
  • Interleukin-6 is a needed proinflammatory cytokine in the prolonged neural activity and transcriptional activation of corticotropin-releasing factor during endotoxemia., , Endocrinology, 1999, 10.1210/endo.140.9.6983
  • Influence of interleukin-6 on neural activity and transcription of the gene encoding corticotrophin-releasing factor in the rat brain: an effect depending upon the route of administration., , The European journal of neuroscience, 1997, 10.1111/j.1460-9568.1997.tb01500.x
  • CXCL10 triggers early microglial activation in the cuprizone model., , Journal of immunology (Baltimore, Md. : 1950), 2015, 10.4049/jimmunol.1401459
  • Interleukin-36γ is expressed by neutrophils and can activate microglia, but has no role in experimental autoimmune encephalomyelitis., , Journal of neuroinflammation, 2015, 10.1186/s12974-015-0392-7
  • Crawling phagocytes recruited in the brain vasculature after pertussis toxin exposure through IL6, ICAM1 and ITGαM., , Brain pathology (Zurich, Switzerland), 2011, 10.1111/j.1750-3639.2011.00490.x
  • The inflammasome pyrin contributes to pertussis toxin-induced IL-1β synthesis, neutrophil intravascular crawling and autoimmune encephalomyelitis., , PLoS pathogens, 2014, 10.1371/journal.ppat.1004150
  • CXCL1 can be regulated by IL-6 and promotes granulocyte adhesion to brain capillaries during bacterial toxin exposure and encephalomyelitis., , Journal of neuroinflammation, 2012, 10.1186/1742-2094-9-18
  • Reduced hippocampal neurogenesis in adult transgenic mice with chronic astrocytic production of interleukin-6., , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002
  • Neutrophil perversion in demyelinating autoimmune diseases: Mechanisms to medicine., , Autoimmunity reviews, 2017, 10.1016/j.autrev.2017.01.013
  • Conditional Deletions of Hdc Confirm Roles of Histamine in Anaphylaxis and Circadian Activity but Not in Autoimmune Encephalomyelitis, Luc Vallières, Vincent Pernet, Alexandre Patenaude, Aline Dumas, Julius Baya Mdzomba, Noopur Singh, Françoise Morin, The Journal of Immunology, 2021, 10.4049/jimmunol.2000719
  • Mediators of neuroinflammation., , Mediators of inflammation, 2013, 10.1155/2013/314261
  • Construction of a ganciclovir-sensitive lentiviral vector to assess the influence of angiopoietin-3 and soluble Tie2 on glioma growth., , Journal of neuro-oncology, 2010, 10.1007/s11060-009-0095-y
  • How the blood talks to the brain parenchyma and the paraventricular nucleus of the hypothalamus during systemic inflammatory and infectious stimuli., , Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 2000, 10.1046/j.1525-1373.2000.22304.x
  • Trabedersen, a TGFbeta2-specific antisense oligonucleotide for the treatment of malignant gliomas and other tumors overexpressing TGFbeta2., , IDrugs : the investigational drugs journal, 2009
  • Matrix metalloproteinase 2 attenuates brain tumour growth, while promoting macrophage recruitment and vascular repair., , The Journal of pathology, 2011, 10.1002/path.2854
  • Bone marrow-derived cells that populate the adult mouse brain preserve their hematopoietic identity., , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003
  • Mouse model for ablation of proliferating microglia in acute CNS injuries., , Glia, 2006, 10.1002/glia.20288
  • Several classical mouse inbred strains, including DBA/2, NOD/Lt, FVB/N, and SJL/J, carry a putative loss-of-function allele of Gpr84., , The Journal of heredity, 2013, 10.1093/jhered/est023

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Vincent Renaud - Maîtrise avec mémoire - En cours
  • Reza Taghipourmirakmahaleh - Doctorat - En cours
  • Yu Zhang - Doctorat - En cours
  • Louis Bourhoven - Maîtrise avec mémoire - En cours
  • Lusine Bozoyan - Doctorat - 2016/05
  • Ryder Whittaker Hawkins - Maîtrise avec mémoire - 2018/09
  • Noopur Singh - Doctorat - 2020/09

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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