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Julie Fradette

Professeure titulaire

Julie.Fradette@fmed.ulaval.ca

Département de chirurgie

Centre de recherche en organogenèse expérimentale

Centre de recherche du CHU de Québec - Université Laval

Centre de recherche en arthrite (ARThrite)

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Contribution à la recherche

Thématiques de recherche de la Faculté de médecine

Médecine régénératrice et médecine moléculaire

Domaines de recherche

Médecine régénérative (y compris les cellules souches et le génie tissulaire)
Biologie cellulaire, n.c.a.
Prolifération, différenciation et mort cellulaires
Interactions cellulaires (y compris l'adhérence, la matrice et la paroi cellulaire)
Biologie vasculaire et endothéliale
Sciences des os, de la peau et du cartilage
Autres sciences de la santé, n.c.a.
Génie médical et biomédical, n.c.a.
Biotechnologies médicales, n.c.a.
Dermatologie

Projets de recherche en cours

Urethral reconstruction using tissue engineering, final steps towards clinical translation - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2025-04-01 au 2030-03-31
Clinical trial for dystrophic epidermolysis bullosa (EB) using GMEB-SASS, a genetically modified EB skin substitute - Stem Cell Network / Réseau de cellules souches, co-chercheur - 2025-04-01 au 2028-03-31
GMEB-SASS: The first clinical trial phase I/II using a genetically modified epidermolysis bullosa self-assembled skin substitute to treat dystrophic epidermolysis bullosa, a severe rare skin disease - Instituts de recherche en santé du Canada - Subvention de fonctionnement : Thérapies géniques pour maladies rares - essais cliniques, co-chercheur - 2024-04-01 au 2028-03-31
Engineering bioactive dressings from mesenchymal cells to enhance healing of irradiated skin wounds - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2022-04-01 au 2027-03-31
Toward a combined gene therapy and tissue engineering novel treatment for junctional epidermolysis bullosa - Stem Cell Network / Réseau de cellules souches, co-chercheur - 2025-04-01 au 2027-03-31
Epidermolysis bullosa multidisciplinary team focusing on developing an effective cure for this severe rare skin disease - Instituts de recherche en santé du Canada - Subventions Catalyseur de réseaux, University of Toronto, co-chercheur - 2025-03-01 au 2026-02-28

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Financements des 2 dernières années

Roles of matricryptins (bioactive extracellular matrix fragments) in adipose tissue - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2020-04-01 au 2025-03-31
Urethral reconstruction using tissue engineering, final steps towards clinical translation - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2024-10-01 au 2025-03-31
Développement de greffons d’épiderme autologue en combinant thérapie génique et génie tissulaire pour traiter l’épidermolyse bulleuse jonctionnelle - Fondation du Grand défi Pierre Lavoie, Fondation Courtois, co-chercheur - 2024-04-01 au 2025-03-31
Stem cell-instructive hydrogels for intervertebral disc regeneration - Fonds de recherche du Québec - Santé - Réseaux thématiques de recherche, McGill University, co-chercheur - 2023-04-01 au 2024-03-31
Réseau de thérapie cellulaire, tissulaire et génique du Québec - Fonds de recherche du Québec - Santé - Réseaux thématiques de recherche, chercheur principal - 2019-04-01 au 2024-03-31
Projets structurants ThéCell 2023-2024_Greffons d’épiderme autologue en combinant thérapie génique et génie tissulaire pour traiter l’épidermolyse bulleuse jonctionnelle - Fonds de recherche du Québec - Santé - Réseaux thématiques de recherche, co-chercheur - 2023-04-01 au 2024-03-31
Stimulation biomécanique des cellules primaires du ligament cruciforme antérieur humain pour les applications d'ingénierie tissulaire - Fonds de recherche du Québec - Santé - Réseaux thématiques de recherche, McGill University, co-chercheur - 2023-04-01 au 2024-03-31
Skin Investigation Network of Canada (SkIN Canada) - Instituts de recherche en santé du Canada - Subventions Catalyseur de réseaux, University of Toronto, co-chercheur - 2020-01-01 au 2022-12-31

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Publications

Creating capillary networks within human engineered tissues: Impact of adipocytes and their secretory products, Fradette, J., Proulx, M., Mayrand, D., Vincent, C., Aubin, K., Acta Biomaterialia, 2015, 10.1016/j.actbio.2014.09.044
Engineering naturally-derived human connective tissues for clinical applications using a serum-free production system, Julie Fradette, Jean Ruel, Marc-André Plourde Campagna, Cindy Jean Hayward, Romane Leloup, Alexandra Côté, Meryem Safoine, Biomedical Materials, 2022, 10.1088/1748-605X/ac84b9
In Vitro Prevascularization of Self-Assembled Human Bone-Like Tissues and Preclinical Assessment Using a Rat Calvarial Bone Defect Model, Julie Fradette, François A. Auger, Michel Fortin, William P. Clafshenkel, Todd Galbraith, Fabien Kawecki, Materials, 2021, 10.3390/ma14082023
Normal human Merkel cells are present in epidermal cell populations isolated and cultured from glabrous and hairy skin sites, Germain, L., Roy, A., Caouette-Laberge, L., Couture, V., Beauparlant, A., Guignard, R., Fugère, C., Larouche, D., Fradette, J., Journal of Investigative Dermatology, 2003, 10.1046/j.1523-1747.2003.12024.x
Amino-terminal methionine processing of the protein HPr in Streptococcus salivarius grown in continuous culture, Gingras, S., Fradette, J., Trahan, L., Brochu, D., Vadeboncoeur, C., FEMS Microbiology Letters, 1993, 10.1111/j.1574-6968.1993.tb06385.x
Tissue engineering of skin and cornea: Development of new models for in vitro studies, Germain, L., Guérin, S.L., Fradette, J., Auger, F.A., Duranceau, L., Martel, I., Carrier, P., Robitaille, H., Gaudreault, M., Simard-Bisson, C., Proulx, S., Bisson, F., Larouche, D., Paquet, C., Annals of the New York Academy of Sciences, 2010, 10.1111/j.1749-6632.2009.05373.x
Herpesvirus-mediated systemic delivery of nerve growth factor, Glorioso, J.C., Cohen, J.B., Robbins, P.D., Murphey-Corb, M., Fradette, J., Capuano, S.V., Kaplan, T.J., Goins, W.F., Wolfe, D., Molecular Therapy, 2001, 10.1006/mthe.2000.0225
Targeted gene addition to human mesenchymal stromal cells as a cell-based plasma-soluble protein delivery platform, Beauséjour, C.M., Holmes, M.C., Haddad, E., Spees, J.L., Fradette, J., Eliopoulos, N., Gregory, P.D., Friedman, G., Yao, S., Allard, E., Benabdallah, B.F., Cytotherapy, 2010, 10.3109/14653240903583803
Targeting Cytokines: Evaluating the Potential of Mesenchymal Stem Cell Derived Extracellular Vesicles in the Management of COVID-19, Eric Boilard, Marcia Rosangela Wink, Louis Flamand, Julie Fradette, Luc Vallières, Nicolas Bertrand, Etienne Doré, Isabelle Allaeys, Audrée Laroche, Isabelle Dubuc, Ana Claudia dos Santos Pereira Andrade, Iago Carvalho Schultz, Stem Cell Reviews and Reports, 2024, 10.1007/s12015-024-10794-4
Modulation of the Lipid Profile of Reconstructed Skin Substitutes after Essential Fatty Acid Supplementation Affects Testosterone Permeability, Pouliot, R., Fradette, J., Julien, P., Simard, M., Cells, 2019, 10.3390/cells8101142
Dissociation, Quantification and Culture of Normal Human Merkel Cells Among Epidermal Cell Populations Derived from Glabrous and Hairy Skin Sites, Lucie Germain, Alphonse Roy, Louise Caouette-Laberge, Véronique Couture, Annie Beauparlant, Rina Guignard, Claudia Fugère, Danielle Larouche, Julie Fradette, The Merkel Cell, 2003, 10.1007/978-3-662-10358-6_17
Using human umbilical cord cells for tissue engineering: A comparison with skin cells, Auger, F.A., Guignard, R., Germain, L., Morissette Martin, P., Fradette, J., Hayward, C.J., Differentiation, 2014, 10.1016/j.diff.2014.05.001
The mixed-lineage kinase DLK is a key regulator of 3T3-L1 adipocyte differentiation, Blouin, R., Fradette, J., Daviau, A., Couture, J.-P., PLoS ONE, 2009, 10.1371/journal.pone.0004743
Fibrillin-1 regulates white adipose tissue development, homeostasis, and function, Dieter P. Reinhardt, Svetlana Komarova, Julie Fradette, Kerstin Tiedemann, Muthu L. Muthu, Matrix Biology, 2022, 10.1016/j.matbio.2022.05.002
Adipose-derived stromal/stem cells for bone tissue engineering applications, Julie Fradette, Roberto D. Fanganiello, François A. Auger, Jessica Jann, Fabien Kawecki, Nathalie Faucheux, Scientific Principles of Adipose Stem Cells, 2022, 10.1016/b978-0-12-819376-1.00018-4
Human post-natal stem cells in organs produced by tissue engineering for clinical applications, , Progress in Stem Cell Applications, 2008
High definition confocal imaging modalities for the characterization of tissue-engineered substitutes, Fradette, J., Mayrand, D., Methods in Molecular Biology, 2018, 10.1007/978-1-4939-7799-4_8
Considerations for the clinical use of stem cells in genitourinary regenerative medicine, Bolduc, S., Fradette, J., Chabaud, S., Sorroza-Martinez, L., Caneparo, C., World Journal of Stem Cells, 2021, 10.4252/wjsc.v13.i10.1480
Short-term post-implantation dynamics of in vitro engineered human microvascularized adipose tissues, Fradette, J., Trottier, V., Aubin, K., Boisvert, A., Vincent, C., Mayrand, D., Proulx, M., Biomedical Materials (Bristol), 2018, 10.1088/1748-605X/aadff7
Inflammatory Cytokine Profiles in Visceral and Subcutaneous Adipose Tissues of Obese Patients Undergoing Bariatric Surgery Reveal Lack of Correlation With Obesity or Diabetes, Ramanathan, S., Langlois, M.-F., Menendez, A., Ilangumaran, S., Fradette, J., Rottembourg, D., Brown, C., Mayhue, M., Lacraz, G., Rakotoarivelo, V., EBioMedicine, 2018, 10.1016/j.ebiom.2018.03.004
The mixed lineage kinase leucine-zipper protein kinase exhibits a differentiation-associated localization in normal human skin and induces keratinocyte differentiation upon overexpression, Blouin, R., Nadeau, A., Grondin, G., Guignard, R., Robitaille, H., Fradette, J., Germain, L., Journal of Investigative Dermatology, 2000, 10.1046/j.1523-1747.2000.00024.x
Harvesting the potential of the human umbilical cord: Isolation and characterisation of four cell types for tissue engineering applications, Auger, F.A., Germain, L., Gauvin, R., Guignard, R., Rémy, M., Galbraith, T., Fradette, J., Hayward, C.J., Cells Tissues Organs, 2012, 10.1159/000341254
Top 10 research priorities for cutaneous squamous cell carcinoma: results of the Skin Investigation Network of Canada Priority Setting Initiative, David Zloty, Youwen Zhou, Mary Zawadzki, Helen Wirrell, Debbie Ward, Ilya Shoimer, Girish Shah, Vincent Piguet, Teresa M Petrella, Melissa Nantel-Battista, P Régine Mydlarski, Morris F Manolson, Meggie Morand, Sarvesh Logsetty, Jacklyn Loder, Ivan V Litvinov, Melanie Laurin, Peggy Larsen, Yuanshen Huang, Sandra Holdsworth, Robert Gniadecki, Lucie Germain, Julie Fradette, Patrick Fleming, Aaron M Drucker, Ryan DeCoste, Helen Catherall, Kathleen Barnard, Sheila Au, Yuka Asai, Tarek Afifi, the Skin Investigation Network of Canada Priority Setting Collaborative, An-Wen Chan, Anie Philip, Jan Dutz, Rachael Manion, Omer Kleiner, Zein Doueidari, Philippe Lefrançois, British Journal of Dermatology, 2024, 10.1093/bjd/ljad387
Skin Investigation Network of Canada (SkIN Canada) Priority Setting Initiative ranks the top 10 evidence uncertainties for Merkel cell carcinoma, Youwen Zhou, Mary Zawadaski, Debbie Ward, Girish Shah, Roxana Mititelu, P Régine Mydlarski, Vincent Piguet, Morris F Manolson, Trish MacNeil, Sarvesh Logsetty, Ivan V Litvinov, Melanie Laurin, Yuanshen Huang, Karen Holfeld, Robert Gniadecki, Lucie Germain, Julie Fradette, Aaron M Drucker, Ryan DeCoste, Beverly Bell-Rowbotham, Leslee Beaty, John Beaty, Kathleen Barnard, Yuka Asai, the Skin Investigation Network of Canada Priority Setting Collaborative, An-Wen Chan, Anie Philip, Jan Dutz, Rachael Manion, Omer Kleiner, Carolyn Nessim, Anabel Bergeron, British Journal of Dermatology, 2024, 10.1093/bjd/ljad398
Localization of Merkel cells at hairless and hairy human skin sites using keratin 18., Germain, L., Michel, M., Fradette, J., Godbout, M.J., Biochemistry and cell biology = Biochimie et biologie cellulaire, 1995, 10.1139/o95-070
Phenotypic consequences resulting from a methionine-to-valine substitution at position 48 in the HPr protein of Streptococcus salivarius, Vadeboncoeur, C., Frenette, M., Buckley, N., Vaillancourt, K., Gauthier, L., Fradette, J., Thomas, S., Brochu, D., Plamondon, P., Journal of Bacteriology, 1999, 10.1128/jb.181.22.6914-6921.1999
Adipose-tissue engineering: Taking advantage of the properties of human adipose-derived stem/stromal cells, Fradette, J., Côté, J.-F., Vallée, M., Pathologie Biologie, 2009, 10.1016/j.patbio.2008.04.010
Epigenetic memory of radiotherapy in dermal fibroblasts impairs wound repair capacity in cancer survivors, Ning Xu Landén, Martin Halle, Pehr Sommar, Julie Fradette, Siamak Haghdoost, Louis Archambault, Jenna L. Cash, Michael Crichton, Maria Genander, Evelien Eenjes, Connor A. Bain, Candice Diaz, Monica Maselli, Traimate Sangsuwan, Yongjian Chen, Jennifer Geara, Lihua Luo, Zhuang Liu, Minna Piipponen, Xiaowei Bian, Nature Communications, 2024, 10.1038/s41467-024-53295-1
Dynamic culture induces a cell type-dependent response impacting on the thickness of engineered connective tissues, Fradette, J., Vallée, M., Proulx, M., Gauvin, R., Fortier, G.M., Journal of Tissue Engineering and Regenerative Medicine, 2013, 10.1002/term.522
Assessment of antibacterial properties and skin irritation potential of anodized aluminum impregnated with various quaternary ammonium, Nathalie Faucheux, Louis-Charles Fortier, Gervais Soucy, Myriam Auclair-Gilbert, Julie Fradette, Olivier Drevelle, Suzanne Gascon, Jessica Jann, Biomaterials Advances, 2023, 10.1016/j.bioadv.2023.213433
Considerations in the choice of a skin donor site for harvesting keratinocytes containing a high proportion of stem cells for culture in vitro, Germain, L., Auger, F.A., Genest, H., Bouchard, M., Roy, A., Têtu, F.-A., Gauvin, R., Beauparlant, A., Paquet, C., Larouche, D., Fradette, J., Fugère, C., Lavoie, A., Burns, 2011, 10.1016/j.burns.2010.09.004
Workshop to address gaps in regulation of minimally manipulated autologous cell therapies for homologous use in Canada, Viswanathan, S., Fradette, J., Bedford, P., von Tigerstrom, B., Chisholm, J., Cytotherapy, 2017, 10.1016/j.jcyt.2017.08.015
Expression of α-Smooth Muscle Actin Determines the Fate of Mesenchymal Stromal Cells, Hinz, B., Kapus, A., Davies, J.E., Fradette, J., Talele, N.P., Stem Cell Reports, 2015, 10.1016/j.stemcr.2015.05.004
Adipose-Derived Stem Cells — Are They the Optimal Cell Source for Urinary Tract Regeneration?, Stéphane Bolduc, Julie Fradette, Cassandra R. Goulet, Hazem Orabi, Cells and Biomaterials in Regenerative Medicine, 2014, 10.5772/59223
Oxidative activity of 17β-hydroxysteroid dehydrogenase on testosterone in male abdominal adipose tissues and cellular localization of 17β-HSD type 2, Tchernof, A., Luu-The, V., Cianflone, K., Fradette, J., Poirier, D., Lebel, S., Brochu, G., Mayrand, D., Boulet, M.-M., Pelletier, M., Fouad Mansour, M., Molecular and Cellular Endocrinology, 2015, 10.1016/j.mce.2015.06.016
Adipose Stem Cells, Tissue Engineering, and Solid Organ Transplantation and Regeneration, Julie Fradette, Caroline Vincent, Maryse Proulx, Valérie Trottier, Benoit Labbé, Adipose Stem Cells and Regenerative Medicine, 2011, 10.1007/978-3-642-20012-0_21
Porous matrix and primary-cell culture: A shared concept for skin and cornea tissue engineering,Matrice poreuse et culture de cellules primaires : un même concept pour la reconstruction cutanée et cornéenne, Damour, O., Burillon, C., Nataf, S., Janin-Manificat, H., Fradette, J., Braye, F.-M., Rose, S., Fievet, A., Lequeux, C., Andre, V., Builles, N., Auxenfans, C., Pathologie Biologie, 2009, 10.1016/j.patbio.2008.04.014
A Nanoparticle Ink Allowing the High Precision Visualization of Tissue Engineered Scaffolds by MRI, Marc‐André Fortin, Jean Ruel, André Bégin‐Drolet, Julie Fradette, Dominique Mayrand, Sophie Laurent, Yves Gossuin, Céline Henoumont, Théophraste Lescot, Simon Collin, Philippe Legros, Mariia Kiseleva, Samila Leon‐Chaviano, Small, 2023, 10.1002/smll.202206644
Stem cells of the skin and cornea: Their clinical applications in regenerative medicine, Germain, L., Larouche, D., Gauvin, R., Fradette, J., Proulx, S., Current Opinion in Organ Transplantation, 2011, 10.1097/MOT.0b013e32834254f1
Self-assembled human osseous cell sheets as living biopapers for the laser-assisted bioprinting of human endothelial cells, Devillard, R., Fradette, J., Bourget, J.-M., Auger, F.A., Clafshenkel, W.P., Kawecki, F., Biofabrication, 2018, 10.1088/1758-5090/aabd5b
Transcriptomic Analysis of Mineralized Adipose-Derived Stem Cell Tissues for Calcific Valve Disease Modelling, Francois Gros-Louis, Jean Ruel, Julie Fradette, Arnaud Droit, Stéphanie Bianco, Lydia Touzel-Deschênes, Vincent Roy, Alyssa Brodeur, International Journal of Molecular Sciences, 2024, 10.3390/ijms25042291
IFATS collection: Using human adipose-derived stem/stromal cells for the production of new skin substitutes, Fradette, J., Vincent, C., Germain, L., Marceau-Fortier, G., Trottier, V., Stem Cells, 2008, 10.1634/stemcells.2008-0031
Ionizing Radiation Mediates Dose Dependent Effects Affecting the Healing Kinetics of Wounds Created on Acute and Late Irradiated Skin, Julie Fradette, Louis Archambault, Jean Ruel, Valérie Théberge, Josée Galarneau, Josée Langevin, Caroline Paquette, Meryem Safoine, Cindy J. Hayward, Candice Diaz, Surgeries, 2021, 10.3390/surgeries2010004
Melatonin pretreatment of human adipose tissue - Derived mesenchymal stromal cells enhances their prosurvival and protective effects on human kidney cells, Eliopoulos, N., Fradette, J., Young, Y.K., Zhao, J., American Journal of Physiology - Renal Physiology, 2015, 10.1152/ajprenal.00512.2014
Linoleic acid supplementation of cell culture media influences the phospholipid and lipid profiles of human reconstructed adipose tissue, Fradette, J., Bossé, Y., Vallée, M., Bourget, J.-M., Bérubé, J.-C., Ouellette, M.-È., PLoS ONE, 2019, 10.1371/journal.pone.0224228
Cell sheet technology for tissue engineering: the self-assembly approach using adipose-derived stromal cells., Fradette, J., Marceau-Fortier, G., Labbé, B., Methods in molecular biology (Clifton, N.J.), 2011, 10.1007/978-1-61737-960-4_31
Production of Tissue-Engineered Skin Substitutes for Clinical Applications: Elimination of Serum, Lucie Germain, Julie Fradette, Danielle Larouche, Meryem Safoine, Brice Magne, Étienne Savard, Martin A. Barbier, Sergio Cortez Ghio, Emilie J. Doucet, International Journal of Molecular Sciences, 2023, 10.3390/ijms241612537
Human Organ-Specific 3D Cancer Models Produced by the Stromal Self-Assembly Method of Tissue Engineering for the Study of Solid Tumors, Bolduc, S., Gros-Louis, F., Auger, F.A., Germain, L., Landreville, S., Moulin, V.J., Laverdière, I., Fradette, J., Piquet, L., Grammond, E., Chabaud, S., Blais, M., Vaillancourt-Audet, M., Magne, B., Roy, V., BioMed Research International, 2020, 10.1155/2020/6051210
Enhancing repair of full-thickness excisional wounds in a murine model: Impact of tissue-engineered biological dressings featuring human differentiated adipocytes, Fradette, J., Moulin, V.J., Gagné, V.L., Mayrand, D., Laterreur, V., Maux, A., Morissette Martin, P., Acta Biomaterialia, 2015, 10.1016/j.actbio.2015.04.036
A Cell-Based Self-Assembly Approach for the Production of Human Osseous Tissues from Adipose-Derived Stromal/Stem Cells, Fradette, J., Auger, F.A., Fortin, M., Labbé, B., Blanckaert, C., Kawecki, F., Clafshenkel, W.P., Galbraith, T., Advanced Healthcare Materials, 2017, 10.1002/adhm.201600889
Adipose-derived stromal cells for the reconstruction of a human vesical equivalent, Bolduc, S., Laterreur, V., Gauvin, R., Bernard, G., Fradette, J., Rousseau, A., Journal of Tissue Engineering and Regenerative Medicine, 2015, 10.1002/term.1717
Regeneration of skin and cornea by tissue engineering, Germain, L., Auger, F.A., Carrier, P., Fradette, J., Paquet, C., Larouche, D., Methods in Molecular Biology, 2009, 10.1007/978-1-59745-060-7_15
Top Ten Research Priorities for Psoriasis, Atopic Dermatitis and Hidradenitis Suppurativa: The SkIN Canada Priority Setting Initiative, Veronica Weston, Sandra Walsh, Vicky Verner, Irina Turchin, Jodi Timgren, Jennifer Swan, Cathryn Sibbald, Lauren Reynolds, Cheryl Rosen, Kimberly Seguin, Michele Ramien, Vimal Prajapati, Boluwaji Ogunyemi, Steven Morrison, Charles Lynde, Ushra Khan, Marissa Joseph, Rhiannon Humeny, Sameh Hanna, Tracy Ferris, Catherine Duffy, Katherine Desaulniers, Jacob De Iuliis, Trish Cole, Yee Sing Cheng, Tiffany Chen, Lisa Cenedese, Raed Alhusayen, Mariam Abbas, the Skin Investigation Network of Canada Priority Setting Collaborative, An-Wen Chan, Youwen Zhou, Debbie Ward, Vincent Piguet, P. Régine Mydlarski, Morris Manolson, Sarvesh Logsetty, Ivan Litvinov, Robert Gniadecki, Lucie Germain, Julie Fradette, Kathleen Barnard, Jan Dutz, Anie Philip, Rachael Manion, Omer Kleiner, Aaron M. Drucker, Journal of Cutaneous Medicine and Surgery, 2023, 10.1177/12034754231156103
Informing a Canadian Skin Science Trainee Program Based on the State of Trainee Programs Offered by International Academic Societies, Katlyn Richardson, David Croitoru, Anie Philip, An-Wen Chan, Julie Fradette, Ivan Litvinov, Megan Pawluk, Stephanie G. Brooks, Journal of Cutaneous Medicine and Surgery, 2023, 10.1177/12034754221137570
Isolation and culture of human dermal microvascular endothelial cells, Auger, F.A., Fradette, J., Moulin, V.J., Tremblay, N., Mayrand, D., Bourland, J., Methods in Molecular Biology, 2019, 10.1007/978-1-4939-9473-1_7
Human adipose-derived stromal cells for the production of completely autologous self-assembled tissue-engineered vascular substitutes, Auger, F.A., Fradette, J., Germain, L., Ruel, J., Tondreau, M.Y., Laterreur, V., Vallières, K., Acta Biomaterialia, 2015, 10.1016/j.actbio.2015.06.011
Preclinical Evaluation of BMP-9-Treated Human Bone-like Substitutes for Alveolar Ridge Preservation following Tooth Extraction, Julie Fradette, Nathalie Faucheux, François A. Auger, Michel Fortin, Jessica Jann, Fabien Kawecki, International Journal of Molecular Sciences, 2022, 10.3390/ijms23063302
Deficiency of interleukin-15 confers resistance to obesity by diminishing inflammation and enhancing the thermogenic function of adipose tissues, Ramanathan, S., Ilangumaran, S., Langlois, M.-F., Menendez, A., Rola-Pleszczynski, M., Fradette, J., Ferbeyre, G., Richard, D., Carpentier, A., Grenier, G., Schwertani, A., Stankova, J., Mayhue, M., Noll, C., Vernier, M., Labbé, S.M., Rakotoarivelo, V., Lacraz, G., PLoS ONE, 2016, 10.1371/journal.pone.0162995
Skin stem cell identification and culture: a potential tool for rapid epidermal sheet production and grafting., , Skin substitute production by tissue engineering: clinical and fundamental applications., 1997
Thérapie génique et cellulaire, , Précis de pharmacologie: du fondamental à la clinique (2e édition)., 2015
Human epithelial stem cells persist within tissue-engineered skin produced by the self-assembly approach, Germain, L., Fradette, J., Pouliot, R., Kim, D.H., Dunnwald, M., Robitaille, H., Sauvé, S., Desgagné, M., Paquet, C., Larouche, D., Goyer, B., Beauparlant, A., Fugère, C., Lavoie, A., Tissue Engineering - Part A, 2013, 10.1089/ten.tea.2012.0117
Impact of TNF and IL-1β on capillary networks within engineered human adipose tissues, Fradette, J., Maux, A., Aubin, K., Mayrand, D., Safoine, M., Proulx, M., Journal of Materials Chemistry B, 2016, 10.1039/c6tb00265j
The type I keratin 19 possesses distinct and context-dependent assembly properties, Coulombe, P.A., Seshaiah, P., Germain, L., Fradette, J., Journal of Biological Chemistry, 1998, 10.1074/jbc.273.52.35176
Production of a new tissue-engineered adipose substitute from human adipose-derived stromal cells, Fradette, J., Roy, A., Saint-Pierre, L., Ménard, V., Trottier, V., Vermette, M., Biomaterials, 2007, 10.1016/j.biomaterials.2007.02.030
Characterization of in vitro engineered human adipose tissues: Relevant adipokine secretion and impact of TNF-α, Fradette, J., Roy, A., Têtu, F.A., Côté, J.-F., Audet-Casgrain, M.-A., Proulx, M., Safoine, M., Aubin, K., PLoS ONE, 2015, 10.1371/journal.pone.0137612
A Newly Developed Chemically Defined Serum-Free Medium Suitable for Human Primary Keratinocyte Culture and Tissue Engineering Applications, Lucie Germain, Alain Garnier, Sylvain Guérin, Julie Fradette, Danielle Larouche, Amélie Morissette, Emilie Jolibois, Andréanne Cartier, Gaëtan Le-Bel, Meryem Safoine, Imad Debbah, Emilie J. Doucet, Martin A. Barbier, Sergio Cortez Ghio, International Journal of Molecular Sciences, 2023, 10.3390/ijms24031821
Biofabrication of Sodium Alginate Hydrogel Scaffolds for Heart Valve Tissue Engineering, Jean Ruel, André Bégin-Drolet, Yvan Maciel, Julie Fradette, Yannick Rioux, International Journal of Molecular Sciences, 2022, 10.3390/ijms23158567
Corrigendum to “Inflammatory cytokine profiles in visceral and subcutaneous adipose tissues of obese patients undergoing bariatric surgery reveal lack of correlation with obesity or diabetes” (EBioMedicine (2018) 30 (237–247), (S2352396418300884), (10.1016/j.ebiom.2018.03.004)), Ramanathan, S., Langlois, M.-F., Menendez, A., Ilangumaran, S., Fradette, J., Rottembourg, D., Brown, C., Mayhue, M., Lacraz, G., Rakotoarivelo, V., EBioMedicine, 2018, 10.1016/j.ebiom.2018.10.025
Evolution of three dimensional skin equivalent models reconstructed in vitro by tissue engineering, Damour, O., Auger, F.A., Braye, F., Bechetoille, N., Kinikoglu, B., Germain, L., Lequeux, C., Fradette, J., Auxenfans, C., European Journal of Dermatology, 2009, 10.1684/ejd.2008.0573
Normal human epithelial cells regulate the size and morphology of tissue-engineered capillaries, Germain, L., Auger, F.A., Berthod, F., Baker, K., Roberge, C.J., Tomasetig, F., Fortin, V., Fradette, J., Rochon, M.-H., Tissue Engineering - Part A, 2010, 10.1089/ten.tea.2009.0090
Role of the TGF-β pathway in dedifferentiation of human mature adipocytes, Tchernof, A., Fradette, J., Lescelleur, O., Marceau, S., Pelletier, M., Lessard, J., Côté, J.A., FEBS Open Bio, 2017, 10.1002/2211-5463.12250
Investigation of Omega-3 Polyunsaturated Fatty Acid Biological Activity in a Tissue-Engineered Skin Model Involving Psoriatic Cells, Pouliot, R., Fradette, J., Julien, P., Flamand, N., Guérin, S.L., Martin, C., Morin, S., Rioux, G., Simard, M., Journal of Investigative Dermatology, 2021, 10.1016/j.jid.2021.02.755
Adipose Derived Stem Cells for treatment of Lower Genitourinary Dysfunction, Cassandra Goulet, Journal of Stem Cell Research & Therapy, 2014, 10.4172/2157-7633.1000190
Magnetic Resonance Imaging of Human Tissue-Engineered Adipose Substitutes, Fradette, J., Fortin, M.-A., Auger, M., Audet, P., Lagueux, J., Aubin, K., Proulx, M., Tissue Engineering - Part C: Methods, 2015, 10.1089/ten.tec.2014.0409
Engineered human organ-specific urethra as a functional substitute, Stéphane Bolduc, Julie Fradette, Stéphane Chabaud, Christophe Caneparo, Scientific Reports, 2022, 10.1038/s41598-022-25311-1
Vibrissa hair bulge houses two populations of skin epithelial stem cells distinct by their keratin profile, Germain, L., Coulombe, P.A., Fradette, J., Tong, X., Larouche, D., FASEB Journal, 2008, 10.1096/fj.07-8109com
Strategies to promote the vascularization of skin substitutes after transplantation, Fradette, J., Bourland, J., Skin Tissue Models, 2018, 10.1016/B978-0-12-810545-0.00008-5
Strategies to promote the vascularization of skin substitutes after transplantation, Julie Fradette, Jennifer Bourland, Skin Tissue Models for Regenerative Medicine, 2018, 10.1016/b978-0-12-810545-0.00008-5
Improving Cutaneous Wound Healing in Diabetic Mice Using Naturally Derived Tissue‐Engineered Biological Dressings Produced under Serum‐Free Conditions, Julie Fradette, Gabrielle-Maude Gingras, Caroline Paquette, Meryem Safoine, Stem Cells International, 2024, 10.1155/2024/3601101
α-Linolenic acid and linoleic acid modulate the lipidome and the skin barrier of a tissue-engineered skin model, Pouliot, R., Flamand, N., Fradette, J., Julien, P., Martin, C., Morin, S., Tremblay, A., Simard, M., Acta Biomaterialia, 2022, 10.1016/j.actbio.2021.11.021
HSV vector-mediated transduction and GDNF secretion from adipose cells, Glorioso, J.C., Flanigan, R.M., Huang, S., Goins, W.F., Wolfe, D., Fradette, J., Gene Therapy, 2005, 10.1038/sj.gt.3302359
Biomimetic Tissue-Engineered Bone Substitutes for Maxillofacial and Craniofacial Repair: The Potential of Cell Sheet Technologies, Fradette, J., Auger, F.A., Fortin, M., Clafshenkel, W.P., Kawecki, F., Advanced Healthcare Materials, 2018, 10.1002/adhm.201700919
Tissue-engineered 3D melanoma model with blood and lymphatic capillaries for drug development, Auger, F.A., Fradette, J., Bourland, J., Scientific Reports, 2018, 10.1038/s41598-018-31502-6
Top 10 research priorities for basal cell carcinoma: results of the Skin Investigation Network of Canada Priority Setting Initiative, Youwen Zhou, Lin Xing, Debbie Ward, Michael Stevens, Girish Shah, Patricia Pearsell, Vincent Piguet, Brandon Pearsell, P Régine Mydlarski, Morris F Manolson, Marilynne Madigan, Jillian Macdonald, Barbara Lokach, Sarvesh Logsetty, Elizabeth Leach, Ivan V Litvinov, Melanie Laurin, Omar Hasan Ali, Robert Gniadecki, Lucie Germain, Julie Fradette, Aaron M Drucker, Jeanne DesBrisay, Ryan DeCoste, Rienk De Vries, Kathleen Barnard, Yuka Asai, An-Wen Chan, the Skin Investigation Network of Canada Priority Setting Collaborative, Jan Dutz, Anie Philip, Rachael Manion, Omer Kleiner, Ilya Shoimer, British Journal of Dermatology, 2024, 10.1093/bjd/ljad391

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Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2020/06

Yannick Rioux - Doctorat - En cours
Elias Cuartas Gómez - Doctorat - En cours
Yoann Tardif - Maîtrise avec mémoire - En cours
Elissa Elia - Doctorat - En cours
Fanny Aline Christine Brunard - Doctorat - En cours
Candice Diaz - Maîtrise avec mémoire - 2020/09
Mélissa Simard - Doctorat - 2021/05
Marie-Ève Ouellette - Doctorat - 2021/09
Morgane Claire Hélène Jaguenaud - Maîtrise avec mémoire - 2022/01
Luis Fernando Sorroza Martinez - Maîtrise avec mémoire - 2022/01
Meryem Safoine - Doctorat - 2023/01
Vida Soltani - Maîtrise avec mémoire - 2024/09

Encadrement d'étudiant(e)s

Direction de recherche dans les domaines suivants :

Biologie cellulaire et moléculaire
Médecine moléculaire
Sciences cliniques et biomédicales

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.

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