Julie Fradette

Professeure titulaire

Julie.Fradette@fmed.ulaval.ca

Département de chirurgie

Centre de recherche en organogenèse expérimentale

Centre de recherche du CHU de Québec - Université Laval

Partager la fiche :

Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Médecine régénératrice et moléculaire

Domaines et intérêts de recherche du (de la) professeur(e) :

Appareil locomoteur et arthrite

Peau
Affections cutanées
Tissu conjonctif
Tissu osseux

Projets de recherche

Engineering bioactive dressings from mesenchymal cells to enhance healing of irradiated skin wounds - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2022-04-01 au 2027-03-31
Roles of matricryptins (bioactive extracellular matrix fragments) in adipose tissue - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2020-04-01 au 2025-03-31
Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
Salaire d'un professeur sous octroi - CHU de Québec – Université Laval – Hôpital l'Enfant-Jésus, chercheur principal - 2007-07-01 au 2024-06-30
Réseau de thérapie cellulaire, tissulaire et génique du Québec - Fonds de recherche du Québec - Santé - Réseaux thématiques de recherche, chercheur principal - 2019-04-01 au 2024-03-31
Tissue Engineering of a functional Urethra for Autologous Reconstruction - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2018-04-01 au 2022-03-31
Design and testing of a next-generation tissue-engineered living human heart valve - Secrétariat des programmes interorganismes à l’intention des établissements - Nouvelles frontières en recherche, co-chercheur - 2020-03-31 au 2022-03-30
Projet de recherche portant sur la guérison des plaies cutanées par l'utilisation des cellules souches et de nouvelles thérapies combinées - Fondation du CHU de Québec, chercheur principal - 2020-04-16 au 2021-04-15
Biofabrication and tissue engineering approaches for enhanced ligament reconstruction - Fonds de recherche du Québec - Santé - Réseaux thématiques de recherche, chercheur principal - 2020-04-01 au 2021-03-31

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Publications

Preclinical Evaluation of BMP-9-Treated Human Bone-like Substitutes for Alveolar Ridge Preservation following Tooth Extraction, Fabien Kawecki, Jessica Jann, Michel Fortin, François A. Auger, Nathalie Faucheux, Julie Fradette, International Journal of Molecular Sciences, 2022, 10.3390/ijms23063302
Adipose-derived stromal/stem cells for bone tissue engineering applications, Nathalie Faucheux, Fabien Kawecki, Jessica Jann, François A. Auger, Roberto D. Fanganiello, Julie Fradette, Scientific Principles of Adipose Stem Cells, 2022, 10.1016/b978-0-12-819376-1.00018-4
α-Linolenic acid and linoleic acid modulate the lipidome and the skin barrier of a tissue-engineered skin model, Simard, M., Tremblay, A., Morin, S., Martin, C., Julien, P., Fradette, J., Flamand, N., Pouliot, R., Acta Biomaterialia, 2022, 10.1016/j.actbio.2021.11.021
In Vitro Prevascularization of Self-Assembled Human Bone-Like Tissues and Preclinical Assessment Using a Rat Calvarial Bone Defect Model, Fabien Kawecki, Todd Galbraith, William P. Clafshenkel, Michel Fortin, François A. Auger, Julie Fradette, Materials, 2021, 10.3390/ma14082023
Considerations for the clinical use of stem cells in genitourinary regenerative medicine, Caneparo, C., Sorroza-Martinez, L., Chabaud, S., Fradette, J., Bolduc, S., World Journal of Stem Cells, 2021, 10.4252/wjsc.v13.i10.1480
Investigation of Omega-3 Polyunsaturated Fatty Acid Biological Activity in a Tissue-Engineered Skin Model Involving Psoriatic Cells, Simard, M., Rioux, G., Morin, S., Martin, C., Guérin, S.L., Flamand, N., Julien, P., Fradette, J., Pouliot, R., Journal of Investigative Dermatology, 2021, 10.1016/j.jid.2021.02.755
Ionizing Radiation Mediates Dose Dependent Effects Affecting the Healing Kinetics of Wounds Created on Acute and Late Irradiated Skin, Candice Diaz, Cindy J. Hayward, Meryem Safoine, Caroline Paquette, Josée Langevin, Josée Galarneau, Valérie Théberge, Jean Ruel, Louis Archambault, Julie Fradette, Surgeries, 2021, 10.3390/surgeries2010004
Human Organ-Specific 3D Cancer Models Produced by the Stromal Self-Assembly Method of Tissue Engineering for the Study of Solid Tumors, Roy, V., Magne, B., Vaillancourt-Audet, M., Blais, M., Chabaud, S., Grammond, E., Piquet, L., Fradette, J., Laverdière, I., Moulin, V.J., Landreville, S., Germain, L., Auger, F.A., Gros-Louis, F., Bolduc, S., BioMed Research International, 2020, 10.1155/2020/6051210
Isolation and culture of human dermal microvascular endothelial cells, Bourland, J., Mayrand, D., Tremblay, N., Moulin, V.J., Fradette, J., Auger, F.A., Methods in Molecular Biology, 2019, 10.1007/978-1-4939-9473-1_7
Linoleic acid supplementation of cell culture media influences the phospholipid and lipid profiles of human reconstructed adipose tissue, Ouellette, M.-È., Bérubé, J.-C., Bourget, J.-M., Vallée, M., Bossé, Y., Fradette, J., PLoS ONE, 2019, 10.1371/journal.pone.0224228
Modulation of the Lipid Profile of Reconstructed Skin Substitutes after Essential Fatty Acid Supplementation Affects Testosterone Permeability, Simard, M., Julien, P., Fradette, J., Pouliot, R., Cells, 2019, 10.3390/cells8101142
Biomimetic Tissue-Engineered Bone Substitutes for Maxillofacial and Craniofacial Repair: The Potential of Cell Sheet Technologies, Kawecki, F., Clafshenkel, W.P., Fortin, M., Auger, F.A., Fradette, J., Advanced Healthcare Materials, 2018, 10.1002/adhm.201700919
Corrigendum to “Inflammatory cytokine profiles in visceral and subcutaneous adipose tissues of obese patients undergoing bariatric surgery reveal lack of correlation with obesity or diabetes” (EBioMedicine (2018) 30 (237–247), (S2352396418300884), (10.1016/j.ebiom.2018.03.004)), Rakotoarivelo, V., Lacraz, G., Mayhue, M., Brown, C., Rottembourg, D., Fradette, J., Ilangumaran, S., Menendez, A., Langlois, M.-F., Ramanathan, S., EBioMedicine, 2018, 10.1016/j.ebiom.2018.10.025
High definition confocal imaging modalities for the characterization of tissue-engineered substitutes, Mayrand, D., Fradette, J., Methods in Molecular Biology, 2018, 10.1007/978-1-4939-7799-4_8
Inflammatory Cytokine Profiles in Visceral and Subcutaneous Adipose Tissues of Obese Patients Undergoing Bariatric Surgery Reveal Lack of Correlation With Obesity or Diabetes, Rakotoarivelo, V., Lacraz, G., Mayhue, M., Brown, C., Rottembourg, D., Fradette, J., Ilangumaran, S., Menendez, A., Langlois, M.-F., Ramanathan, S., EBioMedicine, 2018, 10.1016/j.ebiom.2018.03.004
Self-assembled human osseous cell sheets as living biopapers for the laser-assisted bioprinting of human endothelial cells, Kawecki, F., Clafshenkel, W.P., Auger, F.A., Bourget, J.-M., Fradette, J., Devillard, R., Biofabrication, 2018, 10.1088/1758-5090/aabd5b
Short-term post-implantation dynamics of in vitro engineered human microvascularized adipose tissues, Proulx, M., Mayrand, D., Vincent, C., Boisvert, A., Aubin, K., Trottier, V., Fradette, J., Biomedical Materials (Bristol), 2018, 10.1088/1748-605X/aadff7
Strategies to promote the vascularization of skin substitutes after transplantation, Bourland, J., Fradette, J., Skin Tissue Models, 2018, 10.1016/B978-0-12-810545-0.00008-5
Strategies to promote the vascularization of skin substitutes after transplantation, Jennifer Bourland, Julie Fradette, Skin Tissue Models for Regenerative Medicine, 2018, 10.1016/b978-0-12-810545-0.00008-5
Tissue-engineered 3D melanoma model with blood and lymphatic capillaries for drug development, Bourland, J., Fradette, J., Auger, F.A., Scientific Reports, 2018, 10.1038/s41598-018-31502-6
A Cell-Based Self-Assembly Approach for the Production of Human Osseous Tissues from Adipose-Derived Stromal/Stem Cells, Galbraith, T., Clafshenkel, W.P., Kawecki, F., Blanckaert, C., Labbé, B., Fortin, M., Auger, F.A., Fradette, J., Advanced Healthcare Materials, 2017, 10.1002/adhm.201600889
Role of the TGF-β pathway in dedifferentiation of human mature adipocytes, Côté, J.A., Lessard, J., Pelletier, M., Marceau, S., Lescelleur, O., Fradette, J., Tchernof, A., FEBS Open Bio, 2017, 10.1002/2211-5463.12250
Workshop to address gaps in regulation of minimally manipulated autologous cell therapies for homologous use in Canada, Chisholm, J., von Tigerstrom, B., Bedford, P., Fradette, J., Viswanathan, S., Cytotherapy, 2017, 10.1016/j.jcyt.2017.08.015
Deficiency of interleukin-15 confers resistance to obesity by diminishing inflammation and enhancing the thermogenic function of adipose tissues, Lacraz, G., Rakotoarivelo, V., Labbé, S.M., Vernier, M., Noll, C., Mayhue, M., Stankova, J., Schwertani, A., Grenier, G., Carpentier, A., Richard, D., Ferbeyre, G., Fradette, J., Rola-Pleszczynski, M., Menendez, A., Langlois, M.-F., Ilangumaran, S., Ramanathan, S., PLoS ONE, 2016, 10.1371/journal.pone.0162995
Impact of TNF and IL-1β on capillary networks within engineered human adipose tissues, Proulx, M., Safoine, M., Mayrand, D., Aubin, K., Maux, A., Fradette, J., Journal of Materials Chemistry B, 2016, 10.1039/c6tb00265j
Adipose-derived stromal cells for the reconstruction of a human vesical equivalent, Rousseau, A., Fradette, J., Bernard, G., Gauvin, R., Laterreur, V., Bolduc, S., Journal of Tissue Engineering and Regenerative Medicine, 2015, 10.1002/term.1717
Characterization of in vitro engineered human adipose tissues: Relevant adipokine secretion and impact of TNF-α, Aubin, K., Safoine, M., Proulx, M., Audet-Casgrain, M.-A., Côté, J.-F., Têtu, F.A., Roy, A., Fradette, J., PLoS ONE, 2015, 10.1371/journal.pone.0137612
Creating capillary networks within human engineered tissues: Impact of adipocytes and their secretory products, Aubin, K., Vincent, C., Proulx, M., Mayrand, D., Fradette, J., Acta Biomaterialia, 2015, 10.1016/j.actbio.2014.09.044
Enhancing repair of full-thickness excisional wounds in a murine model: Impact of tissue-engineered biological dressings featuring human differentiated adipocytes, Morissette Martin, P., Maux, A., Laterreur, V., Mayrand, D., Gagné, V.L., Moulin, V.J., Fradette, J., Acta Biomaterialia, 2015, 10.1016/j.actbio.2015.04.036
Expression of α-Smooth Muscle Actin Determines the Fate of Mesenchymal Stromal Cells, Talele, N.P., Fradette, J., Davies, J.E., Kapus, A., Hinz, B., Stem Cell Reports, 2015, 10.1016/j.stemcr.2015.05.004
Human adipose-derived stromal cells for the production of completely autologous self-assembled tissue-engineered vascular substitutes, Vallières, K., Laterreur, V., Tondreau, M.Y., Ruel, J., Germain, L., Fradette, J., Auger, F.A., Acta Biomaterialia, 2015, 10.1016/j.actbio.2015.06.011
Magnetic Resonance Imaging of Human Tissue-Engineered Adipose Substitutes, Proulx, M., Aubin, K., Lagueux, J., Audet, P., Auger, M., Fortin, M.-A., Fradette, J., Tissue Engineering - Part C: Methods, 2015, 10.1089/ten.tec.2014.0409
Melatonin pretreatment of human adipose tissue - Derived mesenchymal stromal cells enhances their prosurvival and protective effects on human kidney cells, Zhao, J., Young, Y.K., Fradette, J., Eliopoulos, N., American Journal of Physiology - Renal Physiology, 2015, 10.1152/ajprenal.00512.2014
Oxidative activity of 17β-hydroxysteroid dehydrogenase on testosterone in male abdominal adipose tissues and cellular localization of 17β-HSD type 2, Fouad Mansour, M., Pelletier, M., Boulet, M.-M., Mayrand, D., Brochu, G., Lebel, S., Poirier, D., Fradette, J., Cianflone, K., Luu-The, V., Tchernof, A., Molecular and Cellular Endocrinology, 2015, 10.1016/j.mce.2015.06.016
Thérapie génique et cellulaire, , Précis de pharmacologie: du fondamental à la clinique (2e édition)., 2015
Adipose-Derived Stem Cells — Are They the Optimal Cell Source for Urinary Tract Regeneration?, Hazem Orabi, Cassandra R. Goulet, Julie Fradette, Stéphane Bolduc, Cells and Biomaterials in Regenerative Medicine, 2014, 10.5772/59223
Adipose Derived Stem Cells for treatment of Lower Genitourinary Dysfunction, Cassandra Goulet, Journal of Stem Cell Research & Therapy, 2014, 10.4172/2157-7633.1000190
Using human umbilical cord cells for tissue engineering: A comparison with skin cells, Hayward, C.J., Fradette, J., Morissette Martin, P., Guignard, R., Germain, L., Auger, F.A., Differentiation, 2014, 10.1016/j.diff.2014.05.001
Dynamic culture induces a cell type-dependent response impacting on the thickness of engineered connective tissues, Fortier, G.M., Gauvin, R., Proulx, M., Vallée, M., Fradette, J., Journal of Tissue Engineering and Regenerative Medicine, 2013, 10.1002/term.522
Human epithelial stem cells persist within tissue-engineered skin produced by the self-assembly approach, Lavoie, A., Fugère, C., Beauparlant, A., Goyer, B., Larouche, D., Paquet, C., Desgagné, M., Sauvé, S., Robitaille, H., Dunnwald, M., Kim, D.H., Pouliot, R., Fradette, J., Germain, L., Tissue Engineering - Part A, 2013, 10.1089/ten.tea.2012.0117
Harvesting the potential of the human umbilical cord: Isolation and characterisation of four cell types for tissue engineering applications, Hayward, C.J., Fradette, J., Galbraith, T., Rémy, M., Guignard, R., Gauvin, R., Germain, L., Auger, F.A., Cells Tissues Organs, 2012, 10.1159/000341254
Adipose Stem Cells, Tissue Engineering, and Solid Organ Transplantation and Regeneration, Benoit Labbé, Valérie Trottier, Maryse Proulx, Caroline Vincent, Julie Fradette, Adipose Stem Cells and Regenerative Medicine, 2011, 10.1007/978-3-642-20012-0_21
Cell sheet technology for tissue engineering: the self-assembly approach using adipose-derived stromal cells., Labbé, B., Marceau-Fortier, G., Fradette, J., Methods in molecular biology (Clifton, N.J.), 2011, 10.1007/978-1-61737-960-4_31
Considerations in the choice of a skin donor site for harvesting keratinocytes containing a high proportion of stem cells for culture in vitro, Lavoie, A., Fugère, C., Fradette, J., Larouche, D., Paquet, C., Beauparlant, A., Gauvin, R., Têtu, F.-A., Roy, A., Bouchard, M., Genest, H., Auger, F.A., Germain, L., Burns, 2011, 10.1016/j.burns.2010.09.004
Stem cells of the skin and cornea: Their clinical applications in regenerative medicine, Proulx, S., Fradette, J., Gauvin, R., Larouche, D., Germain, L., Current Opinion in Organ Transplantation, 2011, 10.1097/MOT.0b013e32834254f1
Normal human epithelial cells regulate the size and morphology of tissue-engineered capillaries, Rochon, M.-H., Fradette, J., Fortin, V., Tomasetig, F., Roberge, C.J., Baker, K., Berthod, F., Auger, F.A., Germain, L., Tissue Engineering - Part A, 2010, 10.1089/ten.tea.2009.0090
Targeted gene addition to human mesenchymal stromal cells as a cell-based plasma-soluble protein delivery platform, Benabdallah, B.F., Allard, E., Yao, S., Friedman, G., Gregory, P.D., Eliopoulos, N., Fradette, J., Spees, J.L., Haddad, E., Holmes, M.C., Beauséjour, C.M., Cytotherapy, 2010, 10.3109/14653240903583803
Tissue engineering of skin and cornea: Development of new models for in vitro studies, Paquet, C., Larouche, D., Bisson, F., Proulx, S., Simard-Bisson, C., Gaudreault, M., Robitaille, H., Carrier, P., Martel, I., Duranceau, L., Auger, F.A., Fradette, J., Guérin, S.L., Germain, L., Annals of the New York Academy of Sciences, 2010, 10.1111/j.1749-6632.2009.05373.x
Adipose-tissue engineering: Taking advantage of the properties of human adipose-derived stem/stromal cells, Vallée, M., Côté, J.-F., Fradette, J., Pathologie Biologie, 2009, 10.1016/j.patbio.2008.04.010
Evolution of three dimensional skin equivalent models reconstructed in vitro by tissue engineering, Auxenfans, C., Fradette, J., Lequeux, C., Germain, L., Kinikoglu, B., Bechetoille, N., Braye, F., Auger, F.A., Damour, O., European Journal of Dermatology, 2009, 10.1684/ejd.2008.0573
Porous matrix and primary-cell culture: A shared concept for skin and cornea tissue engineering,Matrice poreuse et culture de cellules primaires : un même concept pour la reconstruction cutanée et cornéenne, Auxenfans, C., Builles, N., Andre, V., Lequeux, C., Fievet, A., Rose, S., Braye, F.-M., Fradette, J., Janin-Manificat, H., Nataf, S., Burillon, C., Damour, O., Pathologie Biologie, 2009, 10.1016/j.patbio.2008.04.014
Regeneration of skin and cornea by tissue engineering, Larouche, D., Paquet, C., Fradette, J., Carrier, P., Auger, F.A., Germain, L., Methods in Molecular Biology, 2009, 10.1007/978-1-59745-060-7_15
The mixed-lineage kinase DLK is a key regulator of 3T3-L1 adipocyte differentiation, Couture, J.-P., Daviau, A., Fradette, J., Blouin, R., PLoS ONE, 2009, 10.1371/journal.pone.0004743
Human post-natal stem cells in organs produced by tissue engineering for clinical applications, , Progress in Stem Cell Applications, 2008
IFATS collection: Using human adipose-derived stem/stromal cells for the production of new skin substitutes, Trottier, V., Marceau-Fortier, G., Germain, L., Vincent, C., Fradette, J., Stem Cells, 2008, 10.1634/stemcells.2008-0031
Vibrissa hair bulge houses two populations of skin epithelial stem cells distinct by their keratin profile, Larouche, D., Tong, X., Fradette, J., Coulombe, P.A., Germain, L., FASEB Journal, 2008, 10.1096/fj.07-8109com
Production of a new tissue-engineered adipose substitute from human adipose-derived stromal cells, Vermette, M., Trottier, V., Ménard, V., Saint-Pierre, L., Roy, A., Fradette, J., Biomaterials, 2007, 10.1016/j.biomaterials.2007.02.030
HSV vector-mediated transduction and GDNF secretion from adipose cells, Fradette, J., Wolfe, D., Goins, W.F., Huang, S., Flanigan, R.M., Glorioso, J.C., Gene Therapy, 2005, 10.1038/sj.gt.3302359
Dissociation, Quantification and Culture of Normal Human Merkel Cells Among Epidermal Cell Populations Derived from Glabrous and Hairy Skin Sites, Julie Fradette, Danielle Larouche, Claudia Fugère, Rina Guignard, Annie Beauparlant, Véronique Couture, Louise Caouette-Laberge, Alphonse Roy, Lucie Germain, The Merkel Cell, 2003, 10.1007/978-3-662-10358-6_17
Normal human Merkel cells are present in epidermal cell populations isolated and cultured from glabrous and hairy skin sites, Fradette, J., Larouche, D., Fugère, C., Guignard, R., Beauparlant, A., Couture, V., Caouette-Laberge, L., Roy, A., Germain, L., Journal of Investigative Dermatology, 2003, 10.1046/j.1523-1747.2003.12024.x
Herpesvirus-mediated systemic delivery of nerve growth factor, Wolfe, D., Goins, W.F., Kaplan, T.J., Capuano, S.V., Fradette, J., Murphey-Corb, M., Robbins, P.D., Cohen, J.B., Glorioso, J.C., Molecular Therapy, 2001, 10.1006/mthe.2000.0225
The mixed lineage kinase leucine-zipper protein kinase exhibits a differentiation-associated localization in normal human skin and induces keratinocyte differentiation upon overexpression, Germain, L., Fradette, J., Robitaille, H., Guignard, R., Grondin, G., Nadeau, A., Blouin, R., Journal of Investigative Dermatology, 2000, 10.1046/j.1523-1747.2000.00024.x
Phenotypic consequences resulting from a methionine-to-valine substitution at position 48 in the HPr protein of Streptococcus salivarius, Plamondon, P., Brochu, D., Thomas, S., Fradette, J., Gauthier, L., Vaillancourt, K., Buckley, N., Frenette, M., Vadeboncoeur, C., Journal of Bacteriology, 1999, 10.1128/jb.181.22.6914-6921.1999
The type I keratin 19 possesses distinct and context-dependent assembly properties, Fradette, J., Germain, L., Seshaiah, P., Coulombe, P.A., Journal of Biological Chemistry, 1998, 10.1074/jbc.273.52.35176
Skin stem cell identification and culture: a potential tool for rapid epidermal sheet production and grafting., , Skin substitute production by tissue engineering: clinical and fundamental applications., 1997
Localization of Merkel cells at hairless and hairy human skin sites using keratin 18., Fradette, J., Godbout, M.J., Michel, M., Germain, L., Biochemistry and cell biology = Biochimie et biologie cellulaire, 1995, 10.1139/o95-070
Amino-terminal methionine processing of the protein HPr in Streptococcus salivarius grown in continuous culture, Vadeboncoeur, C., Brochu, D., Trahan, L., Fradette, J., Gingras, S., FEMS Microbiology Letters, 1993, 10.1111/j.1574-6968.1993.tb06385.x

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Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009

Marie-Ève Ouellette - Doctorat - En cours
Meryem Safoine - Doctorat - En cours
André Odjélé - Doctorat - En cours
Yannick Rioux - Maitrîse avec mémoire - En cours
Benoît M.-Labbé - Maitrîse avec mémoire - 2013/01
Catherine Villeneuve - Maitrîse avec mémoire - 2013/01
Kim Aubin - Maitrîse avec mémoire - 2014/05
Pascal Morissette Martin - Maitrîse avec mémoire - 2015/01
Maryse Proulx - Doctorat - 2018/01
Jennifer Bourland - Doctorat - 2018/09
Fabien Kawecki - Doctorat - 2019/01
Candice Diaz - Maitrîse avec mémoire - 2020/09
Mélissa Simard - Doctorat - 2021/05
Luis Fernando Sorroza Martinez - Maitrîse avec mémoire - 2022/01
Morgane Claire Hélène Jaguenaud - Maitrîse avec mémoire - 2022/01

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