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Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche
Axe de recherche de l'Université Laval :
Santé et bien-être durables
Thématiques de recherche de la Faculté de
médecine :
Oncologie
Domaines et intérêts de recherche du (de la)
professeur(e) :
Cancer
Cancer du sein
Cancer héréditaire
Chimiothérapie
Génétique humaine
Dépistage génétique des maladies
Dommages et réparation du génome
Cellulaire
Organisation et fonctions biologiques
Projets de recherche
Canada Research Chair in DNA repair and Cancer Therapeutics- Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2020-07-01 au 2027-06-30
Decoding the DNA double-strand break repair pathways: from mechanistic insights to human genome instability diseases- Instituts de recherche en santé du Canada - Subventions Fondation, chercheur principal - 2018-07-01 au 2025-06-30
Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval- Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
Poly(ADP-ribose) writers, readers, and erasers: Functions in DNA double-strand break repair and synthetic lethality- Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2019-10-01 au 2024-09-30
Characterization of HR-Killer1 and identification of small molecules for cancer therapy and enhanced gene editing using CRISPR/Cas9-based DNA repair strategies- Instituts de recherche en santé du Canada - Subvention Projet, Dalhousie University, co-chercheur - 2018-04-01 au 2023-03-31
Grand prix scientifique- Fondation du cancer du sein du Québec - Prix d'excellence - Grand prix scientifique, chercheur principal - 2022-04-01 au 2023-03-31
Patient stratification based on DNA repair functionality for cancer precision medicine- Fonds de recherche du Québec - Santé, Instituts de recherche en santé du Canada - Subvention d'équipe: ERA-Net PerMed, Vall d'Hebron University Hospital, co-chercheur - 2020-01-01 au 2022-12-31
Bourse de soutien aux nouveaux détenteurs de Chaire de recherche du Canada- Université Laval - Fonds internes - Fonds de soutien aux professeurs-chercheurs bénéficiant d’une Chaire de recherche du Canada, chercheur principal - 2020-07-01 au 2022-06-30
Personalized Risk Assesment for Prevention and Early Detection of Breast Cancer : Integration and Implementation (PERSPECTIVE II)- Regroupement de compagnies et corporations canadiennes, Fondation du CHU de Québec, Génome Québec, Ministère de la santé (Ontario), Ministère de l'Économie, de la Science et de l'Innovation, Instituts de recherche en santé du Canada, Fondation du cancer du sein du Québec, Génome Canada - Projets de recherche appliquée à grande échelle - Large-Scale Applied Research Project, co-chercheur - 2017-11-01 au 2022-03-31
Investigating the Role of RECQL in Breast Cancer Susceptibility- Instituts de recherche en santé du Canada - Subvention Projet, University of Toronto, co-chercheur - 2017-04-01 au 2022-03-31
Infrastructure for a Tier I CRC in DNA repair and cancer therapeutics- Fondation Canadienne pour l'innovation (La), Ministère de la Santé et des Services sociaux - Fonds des leaders John-R.-Evans - CRC (anciennement : Chaires de recherche du Canada - infrastructure et Fonds des leaders - Volet 2), chercheur principal - 2020-07-01 au 2022-01-31
Cibler l’instabilité génomique en tant que vulnérabilité essentielle du cancer de l’ovaire- Fonds de recherche du Québec - Santé, IRICoR - ONCOPOLE EMC2: Équipes multi-institutionnelles contre le cancer, Université de Montréal, co-chercheur - 2018-10-01 au 2021-09-30
Rôles des protéines de réparation des cassures double-brin dans la stabilité du génome, l'anémie de Fanconi, et le cancer.- Fonds de recherche du Québec - Santé - Chaires de recherche FRQS, chercheur principal - 2016-07-01 au 2020-06-30
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Publications
RAD51 protects against nonconservative DNA double-strand break repair through a nonenzymatic function., , Nucleic acids research, 2022, 10.1093/nar/gkac073
A DNA repair-independent role for alkyladenine DNA glycosylase in alkylation-induced unfolded protein response., , Proceedings of the National Academy of Sciences of the United States of America, 2022, 10.1073/pnas.2111404119
A functionally impaired missense variant identified in French Canadian families implicates FANCI as a candidate ovarian cancer-predisposing gene., , Genome medicine, 2021, 10.1186/s13073-021-00998-5
Cockayne syndrome group B protein regulates fork restart, fork progression and MRE11-dependent fork degradation in BRCA1/2-deficient cells., , Nucleic acids research, 2021, 10.1093/nar/gkab1173
FAN1 exo- not endo-nuclease pausing on disease-associated slipped-DNA repeats: A mechanism of repeat instability., , Cell reports, 2021, 10.1016/j.celrep.2021.110078
Starvation-induced proteasome assemblies in the nucleus link amino acid supply to apoptosis., , Nature communications, 2021, 10.1038/s41467-021-27306-4
Functions of the CSB Protein at Topoisomerase 2 Inhibitors-Induced DNA Lesions., , Frontiers in cell and developmental biology, 2021, 10.3389/fcell.2021.727836
XAB2 promotes Ku eviction from single-ended DNA double-strand breaks independently of the ATM kinase., , Nucleic acids research, 2021, 10.1093/nar/gkab785
Personalized Risk Assessment for Prevention and Early Detection of Breast Cancer: Integration and Implementation (PERSPECTIVE I&I)., , Journal of personalized medicine, 2021, 10.3390/jpm11060511
Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging., , Journal of visualized experiments : JoVE, 2021, 10.3791/62553
Addressing the dark matter of gene therapy: technical and ethical barriers to clinical application., , Human genetics, 2021, 10.1007/s00439-021-02272-5
Synergistic effects of type I PRMT and PARP inhibitors against non-small cell lung cancer cells., , Clinical epigenetics, 2021, 10.1186/s13148-021-01037-1
Zinc finger protein E4F1 cooperates with PARP-1 and BRG1 to promote DNA double-strand break repair., , Proceedings of the National Academy of Sciences of the United States of America, 2021, 10.1073/pnas.2019408118
Animal models of Fanconi anemia: A developmental and therapeutic perspective on a multifaceted disease., , Seminars in cell & developmental biology, 2021, 10.1016/j.semcdb.2020.11.010
FAN1, a DNA Repair Nuclease, as a Modifier of Repeat Expansion Disorders., , Journal of Huntington's disease, 2021, 10.3233/jhd-200448
MRE11-RAD50-NBS1 Complex Is Sufficient to Promote Transcription by RNA Polymerase II at Double-Strand Breaks by Melting DNA Ends., , Cell reports, 2021, 10.1016/j.celrep.2020.108565
SUMOylation mediates CtIP's functions in DNA end resection and replication fork protection., , Nucleic acids research, 2021, 10.1093/nar/gkaa1232
Development of a 3D functional assay and identification of biomarkers, predictive for response of high-grade serous ovarian cancer (HGSOC) patients to poly-ADP ribose polymerase inhibitors (PARPis): targeted therapy., , Journal of translational medicine, 2020, 10.1186/s12967-020-02613-4
PALB2 Variants: Protein Domains and Cancer Susceptibility., , Trends in cancer, 2020, 10.1016/j.trecan.2020.10.002
DDX5 resolves R-loops at DNA double-strand breaks to promote DNA repair and avoid chromosomal deletions., , NAR cancer, 2020, 10.1093/narcan/zcaa028
Genome-wide R-loop analysis defines unique roles for DDX5, XRN2, and PRMT5 in DNA/RNA hybrid resolution., , Life science alliance, 2020, 10.26508/lsa.202000762
Limiting the DNA Double-Strand Break Resectosome for Genome Protection., , Trends in biochemical sciences, 2020, 10.1016/j.tibs.2020.05.003
Missense PALB2 germline variant disrupts nuclear localization of PALB2 in a patient with breast cancer., , Familial cancer, 2020, 10.1007/s10689-020-00163-8
Variants of uncertain clinical significance in hereditary breast and ovarian cancer genes: best practices in functional analysis for clinical annotation., , Journal of medical genetics, 2020, 10.1136/jmedgenet-2019-106368
A slipped-CAG DNA-binding small molecule induces trinucleotide-repeat contractions in vivo., , Nature genetics, 2020, 10.1038/s41588-019-0575-8
The Canadian Rare Diseases Models and Mechanisms (RDMM) Network: Connecting Understudied Genes to Model Organisms., , American journal of human genetics, 2020, 10.1016/j.ajhg.2020.01.009
Functional analysis of genetic variants in the high-risk breast cancer susceptibility gene PALB2., , Nature communications, 2019, 10.1038/s41467-019-13194-2
A global functional analysis of missense mutations reveals two major hotspots in the PALB2 tumor suppressor., , Nucleic acids research, 2019, 10.1093/nar/gkz780
CSB interacts with BRCA1 in late S/G2 to promote MRN- and CtIP-mediated DNA end resection., , Nucleic acids research, 2019, 10.1093/nar/gkz784
Functional characterization of 84 PALB2 variants of uncertain significance., , Genetics in medicine : official journal of the American College of Medical Genetics, 2019, 10.1038/s41436-019-0682-z
Interactions of the Rad51 inhibitor DIDS with human and bovine serum albumins: Optical spectroscopy and isothermal calorimetry approaches., , Biochimie, 2019, 10.1016/j.biochi.2019.09.016
A Fanci knockout mouse model reveals common and distinct functions for FANCI and FANCD2., , Nucleic acids research, 2019, 10.1093/nar/gkz514
Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks., , Nature communications, 2019, 10.1038/s41467-019-10741-9
Arginine methylation of the DDX5 helicase RGG/RG motif by PRMT5 regulates resolution of RNA:DNA hybrids., , The EMBO journal, 2019, 10.15252/embj.2018100986
SAM68 interaction with U1A modulates U1 snRNP recruitment and regulates mTor pre-mRNA splicing., , Nucleic acids research, 2019, 10.1093/nar/gkz099
Novel RNA and DNA strand exchange activity of the PALB2 DNA binding domain and its critical role for DNA repair in cells., , eLife, 2019, 10.7554/elife.44063
Emerging roles of eraser enzymes in the dynamic control of protein ADP-ribosylation., , Nature communications, 2019, 10.1038/s41467-019-08859-x
BRN2 suppresses apoptosis, reprograms DNA damage repair, and is associated with a high somatic mutation burden in melanoma., , Genes & development, 2019, 10.1101/gad.314633.118
PRMT7 methylates eukaryotic translation initiation factor 2α and regulates its role in stress granule formation., , Molecular biology of the cell, 2019, 10.1091/mbc.e18-05-0330
The Tumor Suppressor PALB2: Inside Out., , Trends in biochemical sciences, 2019, 10.1016/j.tibs.2018.10.008
DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells., , Nature, 2018, 10.1038/s41586-018-0670-5
Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1., , Nature communications, 2018, 10.1038/s41467-018-06854-2
Phospho-dependent recruitment of the yeast NuA4 acetyltransferase complex by MRX at DNA breaks regulates RPA dynamics during resection., , Proceedings of the National Academy of Sciences of the United States of America, 2018, 10.1073/pnas.1806513115
SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice., , The EMBO journal, 2018, 10.15252/embj.2018100158
Replication Protein A Availability during DNA Replication Stress Is a Major Determinant of Cisplatin Resistance in Ovarian Cancer Cells., , Cancer research, 2018, 10.1158/0008-5472.can-18-0618
Targeting Allostery with Avatars to Design Inhibitors Assessed by Cell Activity: Dissecting MRE11 Endo- and Exonuclease Activities., , Methods in enzymology, 2018, 10.1016/bs.mie.2017.11.030
RECQ-like helicases Sgs1 and BLM regulate R-loop-associated genome instability., , The Journal of cell biology, 2017, 10.1083/jcb.201703168
The identification of FANCD2 DNA binding domains reveals nuclear localization sequences., , Nucleic acids research, 2017, 10.1093/nar/gkx543
Cumulative defects in DNA repair pathways drive the PARP inhibitor response in high-grade serous epithelial ovarian cancer cell lines., , Oncotarget, 2017, 10.18632/oncotarget.10308
Lysine methylation of FEN1 by SET7 is essential for its cellular response to replicative stress., , Oncotarget, 2017, 10.18632/oncotarget.18070
Cancer-causing mutations in the tumor suppressor PALB2 reveal a novel cancer mechanism using a hidden nuclear export signal in the WD40 repeat motif., , Nucleic acids research, 2017, 10.1093/nar/gkx011
A PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylation., , eLife, 2017, 10.7554/elife.20922
Coupling of Homologous Recombination and the Checkpoint by ATR., , Molecular cell, 2017, 10.1016/j.molcel.2016.12.007
CRISPR/Cas9 Gene Editing: From Basic Mechanisms to Improved Strategies for Enhanced Genome Engineering In Vivo., , Current gene therapy, 2017, 10.2174/1566523217666171122094629
Different non-synonymous polymorphisms modulate the interaction of the WRN protein to its protein partners and its enzymatic activities., , Oncotarget, 2016, 10.18632/oncotarget.13341
Roles for APRIN (PDS5B) in homologous recombination and in ovarian cancer prediction., , Nucleic acids research, 2016, 10.1093/nar/gkw921
Special AT-rich Sequence-binding Protein 1 (SATB1) Functions as an Accessory Factor in Base Excision Repair., , The Journal of biological chemistry, 2016, 10.1074/jbc.m116.735696
Chromosomal Translocations in the Parasite Leishmania by a MRE11/RAD50-Independent Microhomology-Mediated End Joining Mechanism., , PLoS genetics, 2016, 10.1371/journal.pgen.1006117
ABRAXAS (FAM175A) and Breast Cancer Susceptibility: No Evidence of Association in the Breast Cancer Family Registry., , PloS one, 2016, 10.1371/journal.pone.0156820
[Fanconi anemia animal models - How differences can teach us as much as similarities…]., , Medecine sciences : M/S, 2016, 10.1051/medsci/20163206023
Investigation of the DNA damage response to SFOM-0046, a new small-molecule drug inducing DNA double-strand breaks., , Scientific reports, 2016, 10.1038/srep23302
HELB Is a Feedback Inhibitor of DNA End Resection., , Molecular cell, 2016, 10.1016/j.molcel.2015.12.013
DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of Cancer., , Biomolecules, 2015, 10.3390/biom5043204
The RNF138 E3 ligase displaces Ku to promote DNA end resection and regulate DNA repair pathway choice., , Nature cell biology, 2015, 10.1038/ncb3259
Synthesis and biological evaluation of novel N-phenyl ureidobenzenesulfonate derivatives as potential anticancer agents. Part 2. Modulation of the ring B., , European journal of medicinal chemistry, 2015, 10.1016/j.ejmech.2015.09.012
CRB3A Controls the Morphology and Cohesion of Cancer Cells through Ehm2/p114RhoGEF-Dependent Signaling., , Molecular and cellular biology, 2015, 10.1128/mcb.00673-15
Arginine methylation of hnRNPUL1 regulates interaction with NBS1 and recruitment to sites of DNA damage., , Scientific reports, 2015, 10.1038/srep10475
E4F1 is a master regulator of CHK1-mediated functions., , Cell reports, 2015, 10.1016/j.celrep.2015.03.019
Roles of Rad51 paralogs for promoting homologous recombination in Leishmania infantum., , Nucleic acids research, 2015, 10.1093/nar/gkv118
Formation of linear amplicons with inverted duplications in Leishmania requires the MRE11 nuclease., , PLoS genetics, 2014, 10.1371/journal.pgen.1004805
Exploring the roles of PALB2 at the crossroads of DNA repair and cancer., , The Biochemical journal, 2014, 10.1042/bj20140208
DNA repair pathways in trypanosomatids: from DNA repair to drug resistance., , Microbiology and molecular biology reviews : MMBR, 2014, 10.1128/mmbr.00045-13
Breast cancer proteins PALB2 and BRCA2 stimulate polymerase η in recombination-associated DNA synthesis at blocked replication forks., , Cell reports, 2014, 10.1016/j.celrep.2014.01.009
Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair., , Proceedings of the National Academy of Sciences of the United States of America, 2013, 10.1073/pnas.1309085110
DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities., , Molecular cell, 2013, 10.1016/j.molcel.2013.11.003
Mammalian protein arginine methyltransferase 7 (PRMT7) specifically targets RXR sites in lysine- and arginine-rich regions., , The Journal of biological chemistry, 2013, 10.1074/jbc.m113.525345
GST-His purification: a two-step affinity purification protocol yielding full-length purified proteins., , Journal of visualized experiments : JoVE, 2013, 10.3791/50320
[Functions of PALB2 and BRCA2 tumor suppressors in DNA double-strand break repair]., , Medecine sciences : M/S, 2013, 10.1051/medsci/2013293017
Fanconi anemia group J helicase and MRE11 nuclease interact to facilitate the DNA damage response., , Molecular and cellular biology, 2013, 10.1128/mcb.01256-12
Detection of the HIV-1 minus-strand-encoded antisense protein and its association with autophagy., , Journal of virology, 2013, 10.1128/jvi.00225-13
Reprogramming cellular events by poly(ADP-ribose)-binding proteins., , Molecular aspects of medicine, 2012, 10.1016/j.mam.2012.12.005
The RAD51 paralogs ensure cellular protection against mitotic defects and aneuploidy., , Journal of cell science, 2012, 10.1242/jcs.114595
PARP activation regulates the RNA-binding protein NONO in the DNA damage response to DNA double-strand breaks., , Nucleic acids research, 2012, 10.1093/nar/gks798
Synthesis, biological evaluation, and structure-activity relationships of novel substituted N-phenyl ureidobenzenesulfonate derivatives blocking cell cycle progression in S-phase and inducing DNA double-strand breaks., , Journal of medicinal chemistry, 2012, 10.1021/jm3006492
A requirement for polymerized actin in DNA double-strand break repair., , Nucleus (Austin, Tex.), 2012, 10.4161/nucl.21055
Interactions between BRCA2 and RAD51 for promoting homologous recombination in Leishmania infantum., , Nucleic acids research, 2012, 10.1093/nar/gks306
CBX4-mediated SUMO modification regulates BMI1 recruitment at sites of DNA damage., , Nucleic acids research, 2012, 10.1093/nar/gks222
The microRNA pathway controls germ cell proliferation and differentiation in C. elegans., , Cell research, 2012, 10.1038/cr.2012.31
ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repair., , EMBO reports, 2012, 10.1038/embor.2011.243
The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation., , Cell research, 2011, 10.1038/cr.2011.128
Partners apart: Smc6-independent DNA binding activity of Smc5 on single-strand DNA., , Cell cycle (Georgetown, Tex.), 2011, 10.4161/cc.10.7.15212
Proteome-wide identification of WRN-interacting proteins in untreated and nuclease-treated samples., , Journal of proteome research, 2011, 10.1021/pr100990s
Lactococcal phage p2 ORF35-Sak3 is an ATPase involved in DNA recombination and AbiK mechanism., , Molecular microbiology, 2011, 10.1111/j.1365-2958.2011.07561.x
The effect of a DNA repair gene on cellular invasiveness: XRCC3 over-expression in breast cancer cells., , PloS one, 2011, 10.1371/journal.pone.0016394
A key role for poly(ADP-ribose) polymerase 3 in ectodermal specification and neural crest development., , PloS one, 2011, 10.1371/journal.pone.0015834
Irinotecan and DNA-PKcs inhibitors synergize in killing of colon cancer cells., , Investigational new drugs, 2011, 10.1007/s10637-010-9626-9
Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination., , Nature structural & molecular biology, 2010, 10.1038/nsmb.1915
FANCD2: A DNA binding protein regulated by MRE11-RAD50-NBS1., , Cell cycle (Georgetown, Tex.), 2010, 10.4161/cc.9.2.10492
Deciphering the function of lactococcal phage ul36 Sak domains., , Journal of structural biology, 2009, 10.1016/j.jsb.2009.12.021
Structure and function of phage p2 ORF34(p2), a new type of single-stranded DNA binding protein., , Molecular microbiology, 2009, 10.1111/j.1365-2958.2009.06844.x
MRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repair., , The EMBO journal, 2009, 10.1038/emboj.2009.193
The Werner syndrome protein affects the expression of genes involved in adipogenesis and inflammation in addition to cell cycle and DNA damage responses., , Cell cycle (Georgetown, Tex.), 2009, 10.4161/cc.8.13.8925
Recovery of deficient homologous recombination in Brca2-depleted mouse cells by wild-type Rad51 expression., , DNA repair, 2008, 10.1016/j.dnarep.2008.10.002
Functional and structural basis for a bacteriophage homolog of human RAD52., , Current biology : CB, 2008, 10.1016/j.cub.2008.06.071
A glycine-arginine domain in control of the human MRE11 DNA repair protein., , Molecular and cellular biology, 2008, 10.1128/mcb.02025-07
PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites., , The Journal of biological chemistry, 2007, 10.1074/jbc.m706734200
Stimulation of fission yeast and mouse Hop2-Mnd1 of the Dmc1 and Rad51 recombinases., , Nucleic acids research, 2007, 10.1093/nar/gkm174
Twists and turns in the function of DNA damage signaling and repair proteins by post-translational modifications., , DNA repair, 2007, 10.1016/j.dnarep.2006.12.009
Interplay between human DNA repair proteins at a unique double-strand break in vivo., , The EMBO journal, 2006, 10.1038/sj.emboj.7600914
The transcriptional histone acetyltransferase cofactor TRRAP associates with the MRN repair complex and plays a role in DNA double-strand break repair., , Molecular and cellular biology, 2006, 10.1128/mcb.26.2.402-412.2006
Targeting poly(ADP-ribosyl)ation: a promising approach in cancer therapy., , Trends in molecular medicine, 2005, 10.1016/j.molmed.2005.08.003
Methylation of MRE11 regulates its nuclear compartmentalization., , Cell cycle (Georgetown, Tex.), 2005, 10.4161/cc.4.7.1830
[A new role for arginine methylation in DNA repair]., , Medecine sciences : M/S, 2005, 10.1051/medsci/2005216-7579
Fission yeast rad51 and dmc1, two efficient DNA recombinases forming helical nucleoprotein filaments., , Molecular and cellular biology, 2005, 10.1128/mcb.25.11.4377-4387.2005
The Hop2 and Mnd1 proteins act in concert with Rad51 and Dmc1 in meiotic recombination., , Nature structural & molecular biology, 2005, 10.1038/nsmb923
Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control., , Genes & development, 2005, 10.1101/gad.1279805
Exploring the multiple facets of the meiotic recombinase Dmc1., , BioEssays : news and reviews in molecular, cellular and developmental biology, 2004, 10.1002/bies.20150
Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways., , Human molecular genetics, 2004, 10.1093/hmg/ddh135
Conformational changes modulate the activity of human RAD51 protein., , Journal of molecular biology, 2004, 10.1016/j.jmb.2004.02.022
Chromatin remodeling and the maintenance of genome integrity., , Biochimica et biophysica acta, 2004, 10.1016/j.bbaexp.2003.10.016
RAD51C is required for Holliday junction processing in mammalian cells., , Science (New York, N.Y.), 2004, 10.1126/science.1093037
XRCC3 and Rad51 modulate replication fork progression on damaged vertebrate chromosomes., , Molecular cell, 2003, 10.1016/s1097-2765(03)00132-1
Role of mammalian RAD51L2 (RAD51C) in recombination and genetic stability., , The Journal of biological chemistry, 2002, 10.1074/jbc.m201402200
Identification and purification of two distinct complexes containing the five RAD51 paralogs., , Genes & development, 2001, 10.1101/gad.947001
Complex formation by the human RAD51C and XRCC3 recombination repair proteins., , Proceedings of the National Academy of Sciences of the United States of America, 2001, 10.1073/pnas.111005698
Role of BRCA2 in control of the RAD51 recombination and DNA repair protein., , Molecular cell, 2001, 10.1016/s1097-2765(01)00175-7
The Rad51 and Dmc1 recombinases: a non-identical twin relationship., , Trends in biochemical sciences, 2001, 10.1016/s0968-0004(00)01742-4
Reconstitution of the strand invasion step of double-strand break repair using human Rad51 Rad52 and RPA proteins., , Journal of molecular biology, 2000, 10.1006/jmbi.2000.4180
Double-strand break repair in human cells., , Cold Spring Harbor symposia on quantitative biology, 2000, 10.1101/sqb.2000.65.315
The meiosis-specific recombinase hDmc1 forms ring structures and interacts with hRad51., , The EMBO journal, 1999, 10.1093/emboj/18.22.6552
Human Dmc1 protein binds DNA as an octameric ring., , Proceedings of the National Academy of Sciences of the United States of America, 1999, 10.1073/pnas.96.19.10684
Characterization of amino acid substitutions that severely alter the DNA repair functions of Escherichia coli endonuclease IV., , Biochemistry, 1999, 10.1021/bi9824083
A yeast homologue of the human phosphotyrosyl phosphatase activator PTPA is implicated in protection against oxidative DNA damage induced by the model carcinogen 4-nitroquinoline 1-oxide., , The Journal of biological chemistry, 1998, 10.1074/jbc.273.34.21489
The transcriptional activator Imp2p maintains ion homeostasis in Saccharomyces cerevisiae., , Genetics, 1998, 10.1093/genetics/149.2.893
Schizosaccharomyces pombe apn1 encodes a homologue of the Escherichia coli endonuclease IV family of DNA repair proteins., , Biochimica et biophysica acta, 1998, 10.1016/s0167-4781(97)00160-7
Normal processing of AP sites in Apn1-deficient Saccharomyces cerevisiae is restored by Escherichia coli genes expressing either exonuclease III or endonuclease III., , Molecular microbiology, 1997, 10.1046/j.1365-2958.1997.3841748.x
A Saccharomyces cerevisiae phleomycin-sensitive mutant, ph140, is defective in the RAD6 DNA repair gene., , Canadian journal of microbiology, 1996, 10.1139/m96-164
The Caenorhabditis elegans gene CeAPN1 encodes a homolog of Escherichia coli and yeast apurinic/apyrimidinic endonuclease., , Gene, 1996, 10.1016/s0378-1119(96)00375-7
Functional mitochondria are essential for Saccharomyces cerevisiae cellular resistance to bleomycin., , Current genetics, 1996, 10.1007/s002940050133
A Saccharomyces cerevisiae mutant defines a new locus essential for resistance to the antitumour drug bleomycin., , Canadian journal of microbiology, 1996, 10.1139/m96-105
Saccharomyces cerevisiae DNA repair processes: an update., , Molecular and cellular biochemistry, 1996, 10.1007/bf00225884
The Saccharomyces cerevisiae IMP2 gene encodes a transcriptional activator that mediates protection against DNA damage caused by bleomycin and other oxidants., , Molecular and cellular biology, 1996, 10.1128/mcb.16.5.2091
The Schizosaccharomyces pombe spqM gene is a new member of the Qm transcription factor family., , Gene, 1996, 10.1016/0378-1119(95)00853-5
A new chitosanase gene from a Nocardioides sp. is a third member of glycosyl hydrolase family 46., , Microbiology (Reading, England), 1995, 10.1099/13500872-141-10-2629
Effect of regulatory sequence substitution on chitosanase production from a cloned gene in Streptomyces lividans, , In: Chitin World. Ed. Z. Karnicki, M.M. Brzezki, J. Dutkiewicz & A. Wojtasz-Pajak, Editors, Elsevier Applied Science, Amsterdam., 1995
Multiple regulatory elements control the basal promoter activity of the human alpha 4 integrin gene., , DNA and cell biology, 1994, 10.1089/dna.1994.13.1071
Primary sequence of the chitosanase from Streptomyces sp. strain N174 and comparison with other endoglycosidases., , Gene, 1994, 10.1016/0378-1119(94)90738-2
Factors governing efficient chitosanase production by recombinant Streptomyces lividans strains carrying the cloned chs gene from Streptomyces N174., , In: Chitin Enzymology. Ed. R.A.A. Muzzarelli. European Chitin Society, Ancona, 1993
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Contribution à l'enseignement aux cycles supérieurs
Étudiant(e)s dirigé(e)s*
Depuis 2009
Louis Marie Paul Michel Nonfoux - Doctorat - En cours
Adèle Beneyton - Doctorat - En cours
Laure Guitton - Post-doctorat - En cours
Aykut Bostanci - Doctorat - En cours
Richa Chaturvedi - Doctorat - En cours
Nadine Brahiti - Doctorat - En cours
Thibaut Peterlini - Doctorat - En cours
Jacynthe Quinn - Maitrîse avec mémoire - En cours
Yuandi Gao - Doctorat - En cours
Daryl Hyacinth Acuna Ronato - Doctorat - En cours
Gowsica Bojarajan Ramakrishnan - Doctorat - En cours
Sofiane Yacine Mersaoui - Post-doctorat - En cours
Éric Paquet - Doctorat - En cours
Anne-Marie Doyon - Maitrîse avec mémoire - En cours
Andréa Lebel - Doctorat - En cours
Maripier Hainse - Maitrîse avec mémoire - En cours
Larissa Milano de Souza - Post-doctorat - En cours
Anuradha Sakhuja - Maitrîse avec mémoire - 2012/01
Karine Drapeau - Maitrîse avec mémoire - 2012/05
Marie-Michelle Genois - Maitrîse avec mémoire - 2013/05
Jana Krietsch - Doctorat - 2014/05
Ranjan Maity - Doctorat - 2014/05
Joris Pauty - Doctorat - 2015/01
Stéphanie Bérubé - Maitrîse avec mémoire - 2015/05
Elise Loie - Doctorat - 2016/01
Anthony Couturier - Doctorat - 2016/05
Niraj Gaurishankar Joshi - Doctorat - 2016/09
Emilie Dubois - Doctorat - 2018/01
Mandy Ducy - Doctorat - 2019/01
Julia O'Sullivan - Doctorat - 2021/09
Encadrement d'étudiant(e)s pour les programmes suivants :
*Les supervisions d’étudiant(e)s de 1er cycle en
stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées
ultérieurement.
Vice-décanat à la recherche et aux études supérieures Pavillon Ferdinand-Vandry Université Laval 1050, avenue de la Médecine, local 4645 Québec, Québec G1V 0A6 Canada
Catherine Comtois Agente de gestion des études etudes.sup2@fmed.ulaval.ca Biostatistique Épidémiologie Évaluation économique des technologies de la santé Santé publique
Marianne Rivest et Claudia Gonzalez Agentes de gestion des études etudes.sup1@fmed.ulaval.ca Biologie cellulaire et moléculaire Génomique fonctionnelle Médecine moléculaire Microbiologie-immunologie Neurosciences
Isabelle Tremblay Agente de gestion des études etudes.sup3@fmed.ulaval.ca Pédagogie universitaire en sciences de la santé Sciences cliniques et biomédicales Sciences de la réadaptation Prévention et gestion de la santé et de la sécurité au travail