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Jean-Yves Masson

Professeur titulaire

jean-yves.masson@fmed.ulaval.ca

Site personnel

Dép. biologie moléculaire, biochimie médicale et pathologie

Centre de recherche sur le cancer

Centre de recherche du CHU de Québec - Université Laval

Regroupement québécois de recherche sur la fonction, la structure et l'ingénierie des protéines

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Contribution à la recherche

Thématiques de recherche de la Faculté de médecine

Oncologie

Projets de recherche en cours

Defining and targeting the eraser functions of Poly(ADP-ribose) Glycohydrolase (PARG) in PAR-DNA hybrids and DNA double-strand break repair - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2025-07-01 au 2030-06-30
Defining the biological consequences of formaldehyde-induced DNA lesions - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2025-04-01 au 2030-03-31
Roles of the tumor suppressor PALB2 at the intersection of DNA repair and synthetic lethal strategies in cancer - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2024-10-01 au 2029-09-30
Characterization of novel breast cancer susceptibility genes through large-scale targeted sequencing and functional assays. - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2024-04-01 au 2029-03-31
Emerging roles of Zinc Finger PAR-Interacting Proteins (ZIPPs) in DNA double-strand break (DSB) repair: implications in PARPi therapy - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2024-04-01 au 2029-03-31
Characterization of novel breast cancer susceptibility genes through large-scale targeted sequencing and functional assays - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2025-04-01 au 2029-03-31
Canada Research Chair in DNA repair and Cancer Therapeutics - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2020-07-01 au 2027-06-30
Caractérisation de nouveaux gènes de susceptibilité au cancer du sein - Ministère de l'Économie et de l'Innovation et de l'énergie - Programme de soutien aux organismes de recherche et d’innovation (PSO) - International Volet 2C(Ancien PSR-SIIRI), co-chercheur - 2024-02-15 au 2027-04-01
Unveiling the roles of Poly(ADP)ribose Glycohydrolase (PARG) in DNA repair and cancer - Société de recherche sur le cancer - Subvention de fonctionnement, chercheur principal - 2024-09-01 au 2026-08-31
Assays evaluating small molecule RAD51 inhibitors: the road to anti-RAD51 drugs to treat aggressive and drug-resistant breast cancer - Breast Cancer Canada - Research Grant Competition, University of Western Ontario, co-chercheur - 2024-06-30 au 2026-06-29
Réseau de recherche sur le cancer (RRCancer) - Fonds de recherche du Québec - Santé - ONCOPOLE EMC2: Équipes multi-institutionnelles contre le cancer, chercheur principal - 2023-04-01 au 2026-03-31

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Financements des 2 dernières années

Decoding the DNA double-strand break repair pathways: from mechanistic insights to human genome instability diseases - Instituts de recherche en santé du Canada - Subventions Fondation, chercheur principal - 2018-07-01 au 2025-06-30
Poly(ADP-ribose) writers, readers, and erasers: Functions in DNA double-strand break repair and synthetic lethality - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2019-10-01 au 2024-09-30
Fonds de cancérologie et ses fonds liés - Fondation de l'Université Laval - 2005-04-01 au 2024-04-30
Tumor biobanking was supported by the Banque de tissus et de données en cancers solides of the Réseau de recherche sur le cancer (RRCancer)...The RRCancer is funded by the Oncopole...de l'Économie, de l'Innovation et de l'Énergie du Québec. - Fonds de recherche du Québec - Santé - ONCOPOLE EMC2: Équipes multi-institutionnelles contre le cancer, chercheur principal - 2023-04-01 au 2024-03-31
Investigating the Role of RECQL in Breast Cancer Susceptibility - Instituts de recherche en santé du Canada - Subvention Projet, University of Toronto, co-chercheur - 2017-04-01 au 2022-03-31
Personalized Risk Assesment for Prevention and Early Detection of Breast Cancer : Integration and Implementation (PERSPECTIVE II) - Regroupement de compagnies et corporations canadiennes, Fondation du CHU de Québec, Génome Québec, Ministère de la santé (Ontario), Ministère de l'Économie, de la Science et de l'Innovation, Instituts de recherche en santé du Canada, Fondation du cancer du sein du Québec, Génome Canada - Projets de recherche appliquée à grande échelle - Large-Scale Applied Research Project, co-chercheur - 2017-11-01 au 2022-03-31

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Publications

A Saccharomyces cerevisiae mutant defines a new locus essential for resistance to the antitumour drug bleomycin., , Canadian journal of microbiology, 1996, 10.1139/m96-105
The Canadian Rare Diseases Models and Mechanisms (RDMM) Network: Connecting Understudied Genes to Model Organisms., , American journal of human genetics, 2020, 10.1016/j.ajhg.2020.01.009
Twists and turns in the function of DNA damage signaling and repair proteins by post-translational modifications., , DNA repair, 2007, 10.1016/j.dnarep.2006.12.009
Variants of uncertain clinical significance in hereditary breast and ovarian cancer genes: best practices in functional analysis for clinical annotation., , Journal of medical genetics, 2020, 10.1136/jmedgenet-2019-106368
The Caenorhabditis elegans gene CeAPN1 encodes a homolog of Escherichia coli and yeast apurinic/apyrimidinic endonuclease., , Gene, 1996, 10.1016/s0378-1119(96)00375-7
ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repair., , EMBO reports, 2012, 10.1038/embor.2011.243
A yeast homologue of the human phosphotyrosyl phosphatase activator PTPA is implicated in protection against oxidative DNA damage induced by the model carcinogen 4-nitroquinoline 1-oxide., , The Journal of biological chemistry, 1998, 10.1074/jbc.273.34.21489
Missense PALB2 germline variant disrupts nuclear localization of PALB2 in a patient with breast cancer., , Familial cancer, 2020, 10.1007/s10689-020-00163-8
BRN2 suppresses apoptosis, reprograms DNA damage repair, and is associated with a high somatic mutation burden in melanoma., , Genes & development, 2019, 10.1101/gad.314633.118
Special AT-rich Sequence-binding Protein 1 (SATB1) Functions as an Accessory Factor in Base Excision Repair., , The Journal of biological chemistry, 2016, 10.1074/jbc.m116.735696
[Fanconi anemia animal models - How differences can teach us as much as similarities…]., , Medecine sciences : M/S, 2016, 10.1051/medsci/20163206023
SAM68 interaction with U1A modulates U1 snRNP recruitment and regulates mTor pre-mRNA splicing., , Nucleic acids research, 2019, 10.1093/nar/gkz099
Roles of Rad51 paralogs for promoting homologous recombination in Leishmania infantum., , Nucleic acids research, 2015, 10.1093/nar/gkv118
ABRAXAS (FAM175A) and Breast Cancer Susceptibility: No Evidence of Association in the Breast Cancer Family Registry., , PloS one, 2016, 10.1371/journal.pone.0156820
Proteome-wide identification of WRN-interacting proteins in untreated and nuclease-treated samples., , Journal of proteome research, 2011, 10.1021/pr100990s
Novel RNA and DNA strand exchange activity of the PALB2 DNA binding domain and its critical role for DNA repair in cells., , eLife, 2019, 10.7554/elife.44063
The Rad51 and Dmc1 recombinases: a non-identical twin relationship., , Trends in biochemical sciences, 2001, 10.1016/s0968-0004(00)01742-4
Functional mitochondria are essential for Saccharomyces cerevisiae cellular resistance to bleomycin., , Current genetics, 1996, 10.1007/s002940050133
Personalized Risk Assessment for Prevention and Early Detection of Breast Cancer: Integration and Implementation (PERSPECTIVE I&I)., , Journal of personalized medicine, 2021, 10.3390/jpm11060511
XRCC3 and Rad51 modulate replication fork progression on damaged vertebrate chromosomes., , Molecular cell, 2003, 10.1016/s1097-2765(03)00132-1
A Saccharomyces cerevisiae phleomycin-sensitive mutant, ph140, is defective in the RAD6 DNA repair gene., , Canadian journal of microbiology, 1996, 10.1139/m96-164
A new chitosanase gene from a Nocardioides sp. is a third member of glycosyl hydrolase family 46., , Microbiology (Reading, England), 1995, 10.1099/13500872-141-10-2629
[Functions of PALB2 and BRCA2 tumor suppressors in DNA double-strand break repair]., , Medecine sciences : M/S, 2013, 10.1051/medsci/2013293017
PARP activation regulates the RNA-binding protein NONO in the DNA damage response to DNA double-strand breaks., , Nucleic acids research, 2012, 10.1093/nar/gks798
MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription-replication conflicts., , Nature communications, 2019, 10.1038/s41467-019-12271-w
Normal processing of AP sites in Apn1-deficient Saccharomyces cerevisiae is restored by Escherichia coli genes expressing either exonuclease III or endonuclease III., , Molecular microbiology, 1997, 10.1046/j.1365-2958.1997.3841748.x
Characterization of amino acid substitutions that severely alter the DNA repair functions of Escherichia coli endonuclease IV., , Biochemistry, 1999, 10.1021/bi9824083
Cockayne syndrome group B protein regulates fork restart, fork progression and MRE11-dependent fork degradation in BRCA1/2-deficient cells., , Nucleic acids research, 2021, 10.1093/nar/gkab1173
CSB interacts with BRCA1 in late S/G2 to promote MRN- and CtIP-mediated DNA end resection., , Nucleic acids research, 2019, 10.1093/nar/gkz784
A slipped-CAG DNA-binding small molecule induces trinucleotide-repeat contractions in vivo., , Nature genetics, 2020, 10.1038/s41588-019-0575-8
Irinotecan and DNA-PKcs inhibitors synergize in killing of colon cancer cells., , Investigational new drugs, 2011, 10.1007/s10637-010-9626-9
Primary sequence of the chitosanase from Streptomyces sp. strain N174 and comparison with other endoglycosidases., , Gene, 1994, 10.1016/0378-1119(94)90738-2
Arginine methylation of hnRNPUL1 regulates interaction with NBS1 and recruitment to sites of DNA damage., , Scientific reports, 2015, 10.1038/srep10475
Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control., , Genes & development, 2005, 10.1101/gad.1279805
The microRNA pathway controls germ cell proliferation and differentiation in C. elegans., , Cell research, 2012, 10.1038/cr.2012.31
The meiosis-specific recombinase hDmc1 forms ring structures and interacts with hRad51., , The EMBO journal, 1999, 10.1093/emboj/18.22.6552
Reprogramming cellular events by poly(ADP-ribose)-binding proteins., , Molecular aspects of medicine, 2012, 10.1016/j.mam.2012.12.005
Schizosaccharomyces pombe apn1 encodes a homologue of the Escherichia coli endonuclease IV family of DNA repair proteins., , Biochimica et biophysica acta, 1998, 10.1016/s0167-4781(97)00160-7
FANCD2: A DNA binding protein regulated by MRE11-RAD50-NBS1., , Cell cycle (Georgetown, Tex.), 2010, 10.4161/cc.9.2.10492
Phospho-dependent recruitment of the yeast NuA4 acetyltransferase complex by MRX at DNA breaks regulates RPA dynamics during resection., , Proceedings of the National Academy of Sciences of the United States of America, 2018, 10.1073/pnas.1806513115
Starvation-induced proteasome assemblies in the nucleus link amino acid supply to apoptosis., , Nature communications, 2021, 10.1038/s41467-021-27306-4
Emerging roles of eraser enzymes in the dynamic control of protein ADP-ribosylation., , Nature communications, 2019, 10.1038/s41467-019-08859-x
MRE11-RAD50-NBS1 Complex Is Sufficient to Promote Transcription by RNA Polymerase II at Double-Strand Breaks by Melting DNA Ends., , Cell reports, 2021, 10.1016/j.celrep.2020.108565
The Hop2 and Mnd1 proteins act in concert with Rad51 and Dmc1 in meiotic recombination., , Nature structural & molecular biology, 2005, 10.1038/nsmb923
The Werner syndrome protein affects the expression of genes involved in adipogenesis and inflammation in addition to cell cycle and DNA damage responses., , Cell cycle (Georgetown, Tex.), 2009, 10.4161/cc.8.13.8925
HELB Is a Feedback Inhibitor of DNA End Resection., , Molecular cell, 2016, 10.1016/j.molcel.2015.12.013
Fission yeast rad51 and dmc1, two efficient DNA recombinases forming helical nucleoprotein filaments., , Molecular and cellular biology, 2005, 10.1128/mcb.25.11.4377-4387.2005
Synergistic effects of type I PRMT and PARP inhibitors against non-small cell lung cancer cells., , Clinical epigenetics, 2021, 10.1186/s13148-021-01037-1
ZNF768 links oncogenic RAS to cellular senescence., , Nature communications, 2021, 10.1038/s41467-021-24932-w
Multiple regulatory elements control the basal promoter activity of the human alpha 4 integrin gene., , DNA and cell biology, 1994, 10.1089/dna.1994.13.1071
Mammalian protein arginine methyltransferase 7 (PRMT7) specifically targets RXR sites in lysine- and arginine-rich regions., , The Journal of biological chemistry, 2013, 10.1074/jbc.m113.525345
A RAD51 assay feasible in routine tumor samples calls PARP inhibitor response beyond BRCA mutation., , EMBO molecular medicine, 2018, 10.15252/emmm.201809172
A requirement for polymerized actin in DNA double-strand break repair., , Nucleus (Austin, Tex.), 2012, 10.4161/nucl.21055
Functions of the CSB Protein at Topoisomerase 2 Inhibitors-Induced DNA Lesions., , Frontiers in cell and developmental biology, 2021, 10.3389/fcell.2021.727836
E4F1 is a master regulator of CHK1-mediated functions., , Cell reports, 2015, 10.1016/j.celrep.2015.03.019
The RAD51 paralogs ensure cellular protection against mitotic defects and aneuploidy., , Journal of cell science, 2012, 10.1242/jcs.114595
Fanconi anemia group J helicase and MRE11 nuclease interact to facilitate the DNA damage response., , Molecular and cellular biology, 2013, 10.1128/mcb.01256-12
Partners apart: Smc6-independent DNA binding activity of Smc5 on single-strand DNA., , Cell cycle (Georgetown, Tex.), 2011, 10.4161/cc.10.7.15212
Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1., , Nature communications, 2018, 10.1038/s41467-018-06854-2
Recovery of deficient homologous recombination in Brca2-depleted mouse cells by wild-type Rad51 expression., , DNA repair, 2008, 10.1016/j.dnarep.2008.10.002
Identification and purification of two distinct complexes containing the five RAD51 paralogs., , Genes & development, 2001, 10.1101/gad.947001
Deciphering the function of lactococcal phage ul36 Sak domains., , Journal of structural biology, 2009, 10.1016/j.jsb.2009.12.021
DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities., , Molecular cell, 2013, 10.1016/j.molcel.2013.11.003
Addressing the dark matter of gene therapy: technical and ethical barriers to clinical application., , Human genetics, 2021, 10.1007/s00439-021-02272-5
SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice., , The EMBO journal, 2018, 10.15252/embj.2018100158
The transcriptional activator Imp2p maintains ion homeostasis in Saccharomyces cerevisiae., , Genetics, 1998, 10.1093/genetics/149.2.893
Saccharomyces cerevisiae DNA repair processes: an update., , Molecular and cellular biochemistry, 1996, 10.1007/bf00225884
Functional analysis of genetic variants in the high-risk breast cancer susceptibility gene PALB2., , Nature communications, 2019, 10.1038/s41467-019-13194-2
Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair., , Proceedings of the National Academy of Sciences of the United States of America, 2013, 10.1073/pnas.1309085110
RAD51 protects against nonconservative DNA double-strand break repair through a nonenzymatic function., , Nucleic acids research, 2022, 10.1093/nar/gkac073
MRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repair., , The EMBO journal, 2009, 10.1038/emboj.2009.193
Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination., , Nature structural & molecular biology, 2010, 10.1038/nsmb.1915
Different non-synonymous polymorphisms modulate the interaction of the WRN protein to its protein partners and its enzymatic activities., , Oncotarget, 2016, 10.18632/oncotarget.13341
DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells., , Nature, 2018, 10.1038/s41586-018-0670-5
The identification of FANCD2 DNA binding domains reveals nuclear localization sequences., , Nucleic acids research, 2017, 10.1093/nar/gkx543
Animal models of Fanconi anemia: A developmental and therapeutic perspective on a multifaceted disease., , Seminars in cell & developmental biology, 2021, 10.1016/j.semcdb.2020.11.010
Double-strand break repair in human cells., , Cold Spring Harbor symposia on quantitative biology, 2000, 10.1101/sqb.2000.65.315
Effect of regulatory sequence substitution on chitosanase production from a cloned gene in Streptomyces lividans, , In: Chitin World. Ed. Z. Karnicki, M.M. Brzezki, J. Dutkiewicz & A. Wojtasz-Pajak, Editors, Elsevier Applied Science, Amsterdam., 1995
DDX5 resolves R-loops at DNA double-strand breaks to promote DNA repair and avoid chromosomal deletions., , NAR cancer, 2020, 10.1093/narcan/zcaa028
Coupling of Homologous Recombination and the Checkpoint by ATR., , Molecular cell, 2017, 10.1016/j.molcel.2016.12.007
The Tumor Suppressor PALB2: Inside Out., , Trends in biochemical sciences, 2019, 10.1016/j.tibs.2018.10.008
Roles for APRIN (PDS5B) in homologous recombination and in ovarian cancer prediction., , Nucleic acids research, 2016, 10.1093/nar/gkw921
Formation of linear amplicons with inverted duplications in Leishmania requires the MRE11 nuclease., , PLoS genetics, 2014, 10.1371/journal.pgen.1004805
Reconstitution of the strand invasion step of double-strand break repair using human Rad51 Rad52 and RPA proteins., , Journal of molecular biology, 2000, 10.1006/jmbi.2000.4180
Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks., , Nature communications, 2019, 10.1038/s41467-019-10741-9
A key role for poly(ADP-ribose) polymerase 3 in ectodermal specification and neural crest development., , PloS one, 2011, 10.1371/journal.pone.0015834
DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of Cancer., , Biomolecules, 2015, 10.3390/biom5043204
XAB2 promotes Ku eviction from single-ended DNA double-strand breaks independently of the ATM kinase., , Nucleic acids research, 2021, 10.1093/nar/gkab785
Lactococcal phage p2 ORF35-Sak3 is an ATPase involved in DNA recombination and AbiK mechanism., , Molecular microbiology, 2011, 10.1111/j.1365-2958.2011.07561.x
PRMT7 methylates eukaryotic translation initiation factor 2α and regulates its role in stress granule formation., , Molecular biology of the cell, 2019, 10.1091/mbc.e18-05-0330
PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites., , The Journal of biological chemistry, 2007, 10.1074/jbc.m706734200
A Fanci knockout mouse model reveals common and distinct functions for FANCI and FANCD2., , Nucleic acids research, 2019, 10.1093/nar/gkz514
Molecular Determinant of DIDS Analogs Targeting RAD51 Activity., , Molecules (Basel, Switzerland), 2021, 10.3390/molecules26185460
Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways., , Human molecular genetics, 2004, 10.1093/hmg/ddh135
FAN1, a DNA Repair Nuclease, as a Modifier of Repeat Expansion Disorders., , Journal of Huntington's disease, 2021, 10.3233/jhd-200448
DNA repair pathways in trypanosomatids: from DNA repair to drug resistance., , Microbiology and molecular biology reviews : MMBR, 2014, 10.1128/mmbr.00045-13
Interactions of the Rad51 inhibitor DIDS with human and bovine serum albumins: Optical spectroscopy and isothermal calorimetry approaches., , Biochimie, 2019, 10.1016/j.biochi.2019.09.016
Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging., , Journal of visualized experiments : JoVE, 2021, 10.3791/62553
Zinc finger protein E4F1 cooperates with PARP-1 and BRG1 to promote DNA double-strand break repair., , Proceedings of the National Academy of Sciences of the United States of America, 2021, 10.1073/pnas.2019408118
Methylation of MRE11 regulates its nuclear compartmentalization., , Cell cycle (Georgetown, Tex.), 2005, 10.4161/cc.4.7.1830
Functional characterization of 84 PALB2 variants of uncertain significance., , Genetics in medicine : official journal of the American College of Medical Genetics, 2019, 10.1038/s41436-019-0682-z
GST-His purification: a two-step affinity purification protocol yielding full-length purified proteins., , Journal of visualized experiments : JoVE, 2013, 10.3791/50320
Conformational changes modulate the activity of human RAD51 protein., , Journal of molecular biology, 2004, 10.1016/j.jmb.2004.02.022
A DNA repair-independent role for alkyladenine DNA glycosylase in alkylation-induced unfolded protein response., , Proceedings of the National Academy of Sciences of the United States of America, 2022, 10.1073/pnas.2111404119
Interactions between BRCA2 and RAD51 for promoting homologous recombination in Leishmania infantum., , Nucleic acids research, 2012, 10.1093/nar/gks306
A PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylation., , eLife, 2017, 10.7554/elife.20922
A glycine-arginine domain in control of the human MRE11 DNA repair protein., , Molecular and cellular biology, 2008, 10.1128/mcb.02025-07
Synthesis, biological evaluation, and structure-activity relationships of novel substituted N-phenyl ureidobenzenesulfonate derivatives blocking cell cycle progression in S-phase and inducing DNA double-strand breaks., , Journal of medicinal chemistry, 2012, 10.1021/jm3006492
Factors governing efficient chitosanase production by recombinant Streptomyces lividans strains carrying the cloned chs gene from Streptomyces N174., , In: Chitin Enzymology. Ed. R.A.A. Muzzarelli. European Chitin Society, Ancona, 1993
PALB2 self-interaction controls homologous recombination., , Nucleic acids research, 2012, 10.1093/nar/gks807
The transcriptional histone acetyltransferase cofactor TRRAP associates with the MRN repair complex and plays a role in DNA double-strand break repair., , Molecular and cellular biology, 2006, 10.1128/mcb.26.2.402-412.2006
Detection of the HIV-1 minus-strand-encoded antisense protein and its association with autophagy., , Journal of virology, 2013, 10.1128/jvi.00225-13
Human Dmc1 protein binds DNA as an octameric ring., , Proceedings of the National Academy of Sciences of the United States of America, 1999, 10.1073/pnas.96.19.10684
A functionally impaired missense variant identified in French Canadian families implicates FANCI as a candidate ovarian cancer-predisposing gene., , Genome medicine, 2021, 10.1186/s13073-021-00998-5
Complex formation by the human RAD51C and XRCC3 recombination repair proteins., , Proceedings of the National Academy of Sciences of the United States of America, 2001, 10.1073/pnas.111005698
Cancer-causing mutations in the tumor suppressor PALB2 reveal a novel cancer mechanism using a hidden nuclear export signal in the WD40 repeat motif., , Nucleic acids research, 2017, 10.1093/nar/gkx011
FAN1 exo- not endo-nuclease pausing on disease-associated slipped-DNA repeats: A mechanism of repeat instability., , Cell reports, 2021, 10.1016/j.celrep.2021.110078
The Schizosaccharomyces pombe spqM gene is a new member of the Qm transcription factor family., , Gene, 1996, 10.1016/0378-1119(95)00853-5
Genome-wide R-loop analysis defines unique roles for DDX5, XRN2, and PRMT5 in DNA/RNA hybrid resolution., , Life science alliance, 2020, 10.26508/lsa.202000762
SUMOylation mediates CtIP's functions in DNA end resection and replication fork protection., , Nucleic acids research, 2021, 10.1093/nar/gkaa1232
Exploring the multiple facets of the meiotic recombinase Dmc1., , BioEssays : news and reviews in molecular, cellular and developmental biology, 2004, 10.1002/bies.20150
CBX4-mediated SUMO modification regulates BMI1 recruitment at sites of DNA damage., , Nucleic acids research, 2012, 10.1093/nar/gks222
Investigation of the DNA damage response to SFOM-0046, a new small-molecule drug inducing DNA double-strand breaks., , Scientific reports, 2016, 10.1038/srep23302
Role of mammalian RAD51L2 (RAD51C) in recombination and genetic stability., , The Journal of biological chemistry, 2002, 10.1074/jbc.m201402200
The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation., , Cell research, 2011, 10.1038/cr.2011.128
Targeting poly(ADP-ribosyl)ation: a promising approach in cancer therapy., , Trends in molecular medicine, 2005, 10.1016/j.molmed.2005.08.003
Perturbing cohesin dynamics drives MRE11 nuclease-dependent replication fork slowing., , Nucleic acids research, 2019, 10.1093/nar/gky519
Synthesis and biological evaluation of novel N-phenyl ureidobenzenesulfonate derivatives as potential anticancer agents. Part 2. Modulation of the ring B., , European journal of medicinal chemistry, 2015, 10.1016/j.ejmech.2015.09.012
The effect of a DNA repair gene on cellular invasiveness: XRCC3 over-expression in breast cancer cells., , PloS one, 2011, 10.1371/journal.pone.0016394
Cumulative defects in DNA repair pathways drive the PARP inhibitor response in high-grade serous epithelial ovarian cancer cell lines., , Oncotarget, 2017, 10.18632/oncotarget.10308
Replication Protein A Availability during DNA Replication Stress Is a Major Determinant of Cisplatin Resistance in Ovarian Cancer Cells., , Cancer research, 2018, 10.1158/0008-5472.can-18-0618
A global functional analysis of missense mutations reveals two major hotspots in the PALB2 tumor suppressor., , Nucleic acids research, 2019, 10.1093/nar/gkz780
Functional and structural basis for a bacteriophage homolog of human RAD52., , Current biology : CB, 2008, 10.1016/j.cub.2008.06.071
Limiting the DNA Double-Strand Break Resectosome for Genome Protection., , Trends in biochemical sciences, 2020, 10.1016/j.tibs.2020.05.003
Structure and function of phage p2 ORF34(p2), a new type of single-stranded DNA binding protein., , Molecular microbiology, 2009, 10.1111/j.1365-2958.2009.06844.x
The RNF138 E3 ligase displaces Ku to promote DNA end resection and regulate DNA repair pathway choice., , Nature cell biology, 2015, 10.1038/ncb3259
PALB2 Variants: Protein Domains and Cancer Susceptibility., , Trends in cancer, 2020, 10.1016/j.trecan.2020.10.002
Targeting Allostery with Avatars to Design Inhibitors Assessed by Cell Activity: Dissecting MRE11 Endo- and Exonuclease Activities., , Methods in enzymology, 2018, 10.1016/bs.mie.2017.11.030
Chromosomal Translocations in the Parasite Leishmania by a MRE11/RAD50-Independent Microhomology-Mediated End Joining Mechanism., , PLoS genetics, 2016, 10.1371/journal.pgen.1006117
Exploring the roles of PALB2 at the crossroads of DNA repair and cancer., , The Biochemical journal, 2014, 10.1042/bj20140208
[A new role for arginine methylation in DNA repair]., , Medecine sciences : M/S, 2005, 10.1051/medsci/2005216-7579
RAD51C is required for Holliday junction processing in mammalian cells., , Science (New York, N.Y.), 2004, 10.1126/science.1093037
Interplay between human DNA repair proteins at a unique double-strand break in vivo., , The EMBO journal, 2006, 10.1038/sj.emboj.7600914
Arginine methylation of the DDX5 helicase RGG/RG motif by PRMT5 regulates resolution of RNA:DNA hybrids., , The EMBO journal, 2019, 10.15252/embj.2018100986
The Saccharomyces cerevisiae IMP2 gene encodes a transcriptional activator that mediates protection against DNA damage caused by bleomycin and other oxidants., , Molecular and cellular biology, 1996, 10.1128/mcb.16.5.2091
Lysine methylation of FEN1 by SET7 is essential for its cellular response to replicative stress., , Oncotarget, 2017, 10.18632/oncotarget.18070
RECQ-like helicases Sgs1 and BLM regulate R-loop-associated genome instability., , The Journal of cell biology, 2017, 10.1083/jcb.201703168
Breast cancer proteins PALB2 and BRCA2 stimulate polymerase η in recombination-associated DNA synthesis at blocked replication forks., , Cell reports, 2014, 10.1016/j.celrep.2014.01.009
Chromatin remodeling and the maintenance of genome integrity., , Biochimica et biophysica acta, 2004, 10.1016/j.bbaexp.2003.10.016
Role of BRCA2 in control of the RAD51 recombination and DNA repair protein., , Molecular cell, 2001, 10.1016/s1097-2765(01)00175-7
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...

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2020/07

Laure Guitton - Post-doctorat - En cours
Sadaf Valeh Sheida - Doctorat - En cours
Nurgul Atalay - Doctorat - En cours
Louis Marie Paul Michel Nonfoux - Doctorat - En cours
Mélissa Thomas - Post-doctorat - En cours
Larissa Milano de Souza - Post-doctorat - En cours
Sara Berrada - Post-doctorat - En cours
Sofiane Yacine Mersaoui - Post-doctorat - En cours
Yuandi Gao - Maîtrise avec mémoire - 2020/09
Laura Sesma Sanz - Doctorat - 2021/09
Julia O'Sullivan - Doctorat - 2021/09
Thibaut Peterlini - Doctorat - 2022/05
Daryl Hyacinth Acuna Ronato - Doctorat - 2023/05
Adèle Beneyton - Doctorat - 2025/01

Encadrement d'étudiant(e)s

Direction de recherche dans les domaines suivants :

Biologie cellulaire et moléculaire
Médecine moléculaire

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Disponibilité d'encadrement d'étudiant(e)s

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.

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