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Jean Sévigny
Professeur titulaire

Contribution à la recherche
Thématiques de recherche de la Faculté de médecine
- Immunologie-infectiologie
- Santé cardiovasculaire, respiratoire et métabolisme
- Transfert des connaissances
Domaines de recherche
- Immunologie appliquée (y compris le génie des anticorps, la xénotransplantation et les thérapies cellulaires par lymphocytes T)
- Immunologie humorale et immunochimie
- Immunité innée
- Maladies auto-immunes
- Immunologie, n.c.a.
- Enzymes (y compris leurs cinétiques et mécanismes, et les biocatalyseurs)
- Biochimie, n.c.a.
- Prolifération, différenciation et mort cellulaires
- Interactions cellulaires (y compris l'adhérence, la matrice et la paroi cellulaire)
- Signalisation intracellulaire, transduction des signaux, biologie des récepteurs et des membranes
- Biologie cellulaire, n.c.a.
- Microbiome
- Microbiologie, n.c.a.
- Pharmacologie fondamentale
Projets de recherche en cours
- Regroupement Québécois de Recherche sur la Fonction, l’Ingénierie et les Applications des Protéines - Fonds de recherche du Québec - Nature et technologies - Regroupements stratégiques NT, Université du Québec à Montréal - UQAM , co-chercheur - 2024-04-01 au 2030-03-31
- Ectonucleotidases and Extracellular Nucleotides in Smooth Muscle Cell Contraction - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2023-04-01 au 2028-03-31
- A recombinant soluble NTPDase8 as a novel biological treatment for inflammatory bowel disease - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2021-10-01 au 2026-09-30
Financements des 2 dernières années
- Novel P2Y6 antagonists as a potential therapy for inflammatory bowel disease - Crohn et Colite Canada, chercheur principal - 2021-07-01 au 2024-06-30
- Scaling up the production of recombinant human NTPDase8 in CHO expression system for in vivo testing - Fonds de recherche du Québec - Nature et technologies - Projet subsidiaire d'un regroupement stratégique (pour fins de gestion au VRRCI), Université du Québec à Montréal - UQAM , co-chercheur - 2023-09-01 au 2024-03-31
Publications
- Benzo[b]carbazolediones Synthesis and Inhibitory Effects on Nucleotide Pyrophosphatases/Phosphodiesterases, Langer, P, Ehlers, P, Iqbal, J, Sévigny, J, Lecka, J, Khan, SU, Villinger, A, Ohlendorf, L, Molenda, R, Ejaz, SA, Do, HH, ChemistrySelect, 2019, 10.1002/slct.201803061
- Longitudinal analysis of calorie restriction on rat taste bud morphology and expression of sweet taste modulators, Martin, B, Maudsley, S, Sevigny, J, de Cabo, R, Chirdon, P, Wang, R, Cong, WN, Daimon, CM, Cai, H, The journals of gerontology Series A, Biological sciences and medical sciences, 2014, 10.1093/gerona/glt129
- Changes in expression and activity levels of ecto-5'-nucleotidase/CD73 along the mouse female estrous cycle, Martin-Satue, M., Solsona, C., Sevigny, J., Gomez de Aranda, I., Lavoie, E. G., Torrejon-Escribano, B., Aliagas, E., Acta Physiologica, 2010, 10.1111/J.1748-1716.2010.02095.X
- A highly sensitive capillary electrophoresis method using p-nitrophenyl 5'-thymidine monophosphate as a substrate for the monitoring of nucleotide pyrophosphatase/phosphodiesterase activities, Muller, CE, Sevigny, J, Levesque, SA, Lee, SY, Journal of chromatography B, Analytical technologies in the biomedical and life sciences, 2012, 10.1016/j.jchromb.2012.10.044
- Structure-activity relationship study of NPP1 inhibitors based on uracil-N1-(methoxy)ethyl-β-phosphate scaffold, Fischer, B, Senderowitz, H, Sevigny, J, Gendron, FP, Khazanov, N, Arguin, G, Arad, U, Pelletier, J, Nassir, M, European journal of medicinal chemistry, 2019, 10.1016/j.ejmech.2019.111754
- Sulfonylhydrazones: Design, synthesis and investigation of ectonucleotidase (ALP & e5'NT) inhibition activities, Al-Rashida, M, Iqbal, J, Sevigny, J, Pelletier, J, Mohamad, H, Asari, A, Batool, F, Saeed, M, Khan, MS, Mahmood, A, Hameed, A, Younus, HA, Bioorganic chemistry, 2020, 10.1016/j.bioorg.2020.103827
- Synthesis of 2-arylated thiadiazolopyrimidones by Suzuki–Miyaura cross-coupling: a new class of nucleotide pyrophosphatase (NPPs) inhibitors, Langer, P, Iqbal, J, Ehlers, P, Rahman, Q, Sévigny, J, Lecka, J, Safarov, S, Kalugin, SN, Turmukhanova, MZ, Abilov, ZA, Khan, SU, Afzal, S, Ejaz, SA, Ospanov, M, Yelibayeva, N, Jafari, B, RSC advances, 2016, 10.1039/c6ra22750c
- The nucleotide triphosphate dihydrolases CD39 and CD39L1 are expressed in distinct compartments within the rat liver, Sevigny, J., Kruglov, E., Robson, S. C., Dranoff, J. A., 2001, 10.1016/S0016-5085(08)80449-0
- Impact of Ectoenzymes on P2 and P1 Receptor Signaling, Sevigny, Jean, Levesque, Sebastien A., Kukulski, Filip, Advances in Pharmacology, 2011, 10.1016/B978-0-12-385526-8.00009-6
- Assignment of ecto-nucleoside triphosphate diphosphohydrolase-1/cd39 expression to microglia and vasculature of the brain, Zimmermann, H, Di Virgilio, F, Hammer, K, Guckelberger, O, Enjyoji, K, Robson, SC, Sévigny, J, Braun, N, The European journal of neuroscience, 2000
- Down-regulation of NTPDase2 and ADP-sensitive P2 Purinoceptors Correlate with Severity of Symptoms during Experimental Autoimmune Encephalomyelitis, Laketa, D, Nedeljkovic, N, Sevigny, J, Pekovic, S, Bjelobaba, I, Savic, D, Bozic, I, Lavrnja, I, Jakovljevic, M, Frontiers in cellular neuroscience, 2017, 10.3389/fncel.2017.00333
- Perturbations in hemostasis and thrombosis in cd39-mutant mice: implications for experimental therapeutics of CD39/NTPDase-1, Enjyoji, K., Lambert, R. D., Kaczmarek, E., Gaciong, Z., Schulte am Esch, J., 2nd, Guckelberger, O., Sévigny, J., Imai, M., Robson, S. C., Ecto-ATPases and related ectonucleotidases : proceedings of the Second International Workshop on Ecto-ATPases and Related Ecotonucleotidases, held in Diepenbeek, Belgium, June 14-18, 1999, 1999
- Ecto-nucleotidases: Multiplicity and role in the nervous system, Robson, S. C., Sevigny, J., Failer, B. U., Vollmayer, P., Braun, N., Zimmermann, H. I., 2002
- Rat, mouse, and primate models of chronic glaucoma show sustained elevation of extracellular ATP and altered purinergic signaling in the posterior eye, Mitchell, CH, Laties, AM, Zhang, X, Sheffield, VC, Zode, GS, Morrison, JC, Johnson, EC, Kaufman, PL, Gabelt, BT, Sevigny, J, Hu, H, Lu, W, Investigative ophthalmology & visual science, 2015, 10.1167/iovs.14-15891
- Canalicular ecto-ATPase is a novel member of the GDA 1/CD39 NTPase family., Sévigny, Jean, 1999
- Identification of hydrolytically stable and selective P2Y(1) receptor agonists, Fischer, Bilha, Gelinas, Sylvie, Sevigny, Jean, Weisman, Gary A., Lecka, Joanna, Camden, Jean, Elyahu, Shay, 2008
- Impact of ectonucleotidases in autonomic nervous functions, Sevigny, J, Correia-de-Sa, P, Schetinger, MR, Cardoso, AM, Autonomic neuroscience : basic & clinical, 2015, 10.1016/j.autneu.2015.04.014
- Design, synthesis and in vitro and evaluation of novel nalidixic acid derivatives as potent ectonucleotidases inhibitors, Jamshed Iqbal, Qing Huang, Muhammad Muhammad, Salman Alrokayan, Tajamul Hussain, Jean Sévigny, Damita Rai, Ismat Nawaz, Bibi Amina, Journal of Molecular Structure, 2025, 10.1016/j.molstruc.2025.142611
- Udp-Sensitive P2y6 Receptors Play a Dual Role in the Human Urinary Bladder Indirectly Via the Release of Atp from Urothelium, Correia-de-Sa, P., Sevigny, J., Ferreirinha, F., Correia, J., Monteiro, D., Silva, N., Vieira, C., Carneiro, I., Timoteo, M. A., Silva, I., Silva-Ramos, M., 2012
- Identification of the long-known canalicular ecto-ATPase as the novel ecto-nucleotidase NTPDase8, Sevigny, J., Dranoff, J., Pelletier, J., Levesque, S. A., Lecka, J., Fausther, M., 2005
- Differential macrophage activation alters the expression profile of NTPDase and ecto-5'-nucleotidase, Battastini, AM, de Souza Wyse, AT, Schetinger, MR, Sevigny, J, Morrone, FB, Moreira, JC, Filho, AZ, Campesato, LF, Bergamin, LS, Braganhol, E, Zanin, RF, PloS one, 2012, 10.1371/journal.pone.0031205
- Investigation of new quinoline derivatives as promising inhibitors of NTPDases: Synthesis, SAR analysis and molecular docking studies, Hassan, A, Iqbal, J, Sevigny, J, Lecka, J, Zaib, S, Khan, KM, Ur Rahman, S, Murtaza, A, Saeed, A, Afzal, S, Hayat, K, Bioorganic chemistry, 2019, 10.1016/j.bioorg.2019.03.019
- Localization of nucleoside triphosphate diphosphohydrolase-1 (NTPDase1) and NTPDase2 in pancreas and salivary gland, Sévigny, J, Robson, SC, Braun, N, Kordás, K, Guckelberger, O, Bigonnesse, F, Pelletier, J, Kittel, A, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2004, 10.1369/jhc.3A6167.2004
- IL-6 transcriptionally downregulates portal fibroblast Ntpdase2 expression via specific promoter elements, Dranoff, Jonathan A., Sevigny, Jean, Sheung, Nina, Lavoie, elise, Yu, Jin, 2007
- The Purinergic Receptor P2X4 Promotes Th17 Activation and the Development of Arthritis, Aoudjit, F, Sévigny, J, Fortin, PR, Salem, M, Abderrazak, A, Zhao, C, Hamoudi, C, Journal of immunology (Baltimore, Md : 1950), 2022, 10.4049/jimmunol.2100550
- Synthesis and pharmacological characterization of multiply substituted 2H-chromene derivatives as P2Y6 receptor antagonists, Jacobson, K. A., Iqbal, J., Sévigny, J., Pelletier, J., Gopinatth, V., Pramanik, A., Lewicki, S. A., Shah, Q., Jung, Y. H., Bioorganic & medicinal chemistry letters, 2022, 10.1016/j.bmcl.2022.128981
- Diadenosine 5',5''-(boranated)polyphosphonate analogues as selective nucleotide pyrophosphatase/phosphodiesterase inhibitors, Fischer, B, Sevigny, J, Pelletier, J, Levesque, SA, Bigonnesse, F, Haas, M, Reiser, G, Lecka, J, Eliahu, S, Journal of medicinal chemistry, 2010, 10.1021/jm100597c
- Localization of plasma membrane bound NTPDases in the murine reproductive tract, Sevigny, J, Robson, SC, Guckelberger, O, Csizmadia, E, Fausther, M, Pelletier, J, Lavoie, EG, Martin-Satue, M, Histochemistry and cell biology, 2009, 10.1007/s00418-008-0551-3
- Design, synthesis and biological evaluation of trinary benzocoumarin-thiazoles-azomethines derivatives as effective and selective inhibitors of alkaline phosphatase, Iqbal, J, Sevigny, J, Lecka, J, Larik, FA, Ashraf, Z, Saeed, A, Zaib, S, Shabir, G, Mahmood, A, Irum, H, Channar, PA, Bioorganic chemistry, 2019, 10.1016/j.bioorg.2019.103137
- Synthesis and characterization of nucleotide mimetics as inhibitors of ecto-5 '-nucleotidase (CD73) and NTPDase1 (CD39), Mueller, C. E., Zimmermann, H., Sevigny, J., Munkonda, M. N., Lee, S. Y., Iqbal, J., Brunschweiger, A., 2008
- Co-expression of ecto-5 '-nucleotidase/CD73 with NTPDases in the liver distinctly regulates adenosine formation, Sevigny, Jean, Zimmermann, Herbert, Lecka, Joanna, Fausther, Michel, 2008
- Analysis of CD39/ATP diphosphohydrolase (ATPDase) expression in endothelial cells, platelets and leukocytes, Kaczmarek, E, Siegel, JB, Robson, SC, Sévigny, J, Koziak, K, Thrombosis and haemostasis, 1999
- Targeting platelet aggregation: CD39 gene transfer augments nucleoside triphosphate diphosphohydrolase activity in injured rabbit arteries, Conte, MS, Robson, SC, Sévigny, J, Rhynhart, KK, Imai, M, Gangadharan, SP, Surgery, 2001, 10.1067/msy.2001.116032
- Synthesis, characterization and biological evaluation of novel chalcone sulfonamide hybrids as potent intestinal alkaline phosphatase inhibitors, Iqbal, J, Sevigny, J, Lecka, J, Khan, S, Nisa, ZU, Siddique, MN, Saeed, A, Ejaz, SA, Bioorganic chemistry, 2017, 10.1016/j.bioorg.2017.01.003
- The candidate sour taste receptor, PKD2L1, is expressed by type III taste cells in the mouse, Finger, TE, Kinnamon, JC, Sevigny, J, Matsunami, H, Ishimaru, Y, Yang, R, Kataoka, S, Chemical senses, 2008, 10.1093/chemse/bjm083
- 17β-Estradiol-Induced Synaptic Rearrangements Are Accompanied by Altered Ectonucleotidase Activities in Male Rat Hippocampal Synaptosomes, Grkovic, I, Nedeljkovic, N, Stanojlovic, M, Sevigny, J, Martinovic, J, Drakulic, D, Zaric, M, Mitrovic, N, Journal of molecular neuroscience : MN, 2017, 10.1007/s12031-016-0877-6
- 2‐Substituted thienotetrahydropyridine derivatives: Allosteric ectonucleotidase inhibitors, Christa E. Müller, Michael Gütschow, Vigneshwaran Namasivayam, Thanigaimalai Pillaiyar, Jean Sévigny, Julie Pelletier, Katharina Sylvester, Tim Keuler, Sang‐Yong Lee, Markus Pietsch, Salahuddin Mirza, Laura Schäkel, Archiv der Pharmazie, 2021, 10.1002/ardp.202100300
- Impaired Expression of Ectonucleotidases in Ectopic and Eutopic Endometrial Tissue Is in Favor of ATP Accumulation in the Tissue Microenvironment in Endometriosis, Martin-Satue, M, Matias-Guiu, X, Ponce, J, Sevigny, J, a, I, Gomez de Ar, Barri, P, Tresserra, F, Coroleu, B, ez-Montoli, ME, Fern, Vidal, A, Trapero, C, International journal of molecular sciences, 2019, 10.3390/ijms20225532
- Characterization of the Endometrial MSC Marker Ectonucleoside Triphosphate Diphosphohydrolase-2 (NTPDase2/CD39L1) in Low- and High-Grade Endometrial Carcinomas: Loss of Stromal Expression in the Invasive Phenotypes, Martin-Satue, M, Matias-Guiu, X, Ponce, J, ez-Montoli, ME, Fern, Sevigny, J, a, I, Gomez de Ar, Piulats, JM, Vidal, A, Trapero, C, Rodriguez-Martinez, A, Journal of personalized medicine, 2021, 10.3390/jpm11050331
- Transient changes in the localization and activity of ecto-nucleotidases in rat hippocampus following lipopolysaccharide treatment, Kirley, Terence L., Sevigny, Jean, Pelletier, Julie, Sperlagh, Beata, Kittel, Agnes, International Journal of Developmental Neuroscience, 2007, 10.1016/J.IJDEVNEU.2007.05.007
- The E-NTPDase family of ectonucleotidases: Structure function relationships and pathophysiological significance, Zimmermann, H, Sevigny, J, Robson, SC, Purinergic signalling, 2006, 10.1007/s11302-006-9003-5
- Characterization of CD39/vascular ATP diphosphohydrolase (ATPDase), Bach, F. H., Beaudoin, A. R., Sevigny, J., Siegel, J., Koziak, K., Kaczmarek, E., Robson, S. C., 1997
- Characterization of soluble CD39 (SolCD39/NTPDase1) from PiggyBac nonviral system as a tool to control the nucleotides level, Wink, MR, Lenz, G, Sevigny, J, Bertoni, APS, Fontoura, DM, Onzi, GR, Iser, IC, Beckenkamp, LR, The Biochemical journal, 2019, 10.1042/BCJ20190040
- Identification and isolation of a novel liver cell type expressing the ecto-nucleotidase NTPDase 2, Zimmerman, H., Braun, N., Robson, S. C., Sevigny, J., Kruglov, E. A., Dranoff, J. A., 2002
- Functionalized Oxoindolin Hydrazine Carbothioamide Derivatives as Highly Potent Inhibitors of Nucleoside Triphosphate Diphosphohydrolases, Iqbal, J, Sevigny, J, Pelletier, J, Hameed, A, Al-Rashida, M, Afzal, S, Frontiers in pharmacology, 2020, 10.3389/fphar.2020.585876
- Development of a selective and highly sensitive fluorescence assay for nucleoside triphosphate diphosphohydrolase1 (NTPDase1, CD39), Muller, CE, Sevigny, J, Stephan, H, Pelletier, J, Mirza, S, Geiss, J, Namasivayam, V, Luo, X, Lee, SY, The Analyst, 2018, 10.1039/c8an01108g
- Functional expression of the ecto-ATPase NTPDase2 and of nucleotide receptors by neuronal progenitor cells in the adult murine hippocampus, Braun, N, Robson, SC, Sévigny, J, Hammer, K, Raab, S, Kettenmann, H, Wang, L, Zimmermann, H, Shukla, V, Journal of neuroscience research, 2005, 10.1002/jnr.20508
- E-NTPDase family, Sévigny, J, Book E-NTPDase family, 2013, 10.1007/978-1-4419-0461-4_197
- The physiological role of NTPDases (ATP diphosphohydrolases) in mammals, Gendron, F. P., Fischer, B., Sévigny, J., Robson, S. C., Enjyoji, K., Grondin, G., Beaudoin, A. R., Ecto-ATPases and related ectonucleotidases : proceedings of the Second International Workshop on Ecto-ATPases and Related Ecotonucleotidases, held in Diepenbeek, Belgium, June 14-18, 1999, 1999
- IDENTIFICATION OF THE CATALYTIC SUBUNIT OF THE BOVINE LUNG ATP-DIPHOSPHOHYDROLASE, BEAUDOIN, AR, PICHER, M, SEVIGNY, J, Molecular Biology of the Cell, 1995
- Extracellular ATP hydrolysis in Caco-2 human intestinal cell line, Schwarzbaum, PJ, Ostuni, MA, Sévigny, J, Molineris, MP, Gonzalez-Lebrero, R, Rinaldi, DE, Hattab, C, Corradi, G, Faillace, MP, Bazzi, Z, Alvarez, CL, Schachter, J, Biochimica et biophysica acta Biomembranes, 2021, 10.1016/j.bbamem.2021.183679
- Association of the ecto-ATPase NTPDase2 with glial cells of the peripheral nervous system, Zimmermann, H, Hanani, M, Hammer, K, Robson, SC, Sevigny, J, Braun, N, Glia, 2004, 10.1002/glia.10309
- Investigation of quinoline-4-carboxylic acid as a highly potent scaffold for the development of alkaline phosphatase inhibitors: synthesis, SAR analysis and molecular modelling studies, Iqbal, J, Sévigny, J, Millan, JL, Lecka, J, Hameed, S, Ibrar, A, Ejaz, SA, Ali Shah, SJ, Khan, I, RSC advances, 2015, 10.1039/c5ra12455g
- The expression of NTPDase1 and -2 of Leishmania infantum chagasi in bacterial and mammalian cells: Comparative expression, refolding and nucleotidase characterization, Fietto, JLR, Sevigny, J, Almeida, MR, Bressan, GC, Silva-Junior, A, Lecka, J, Pelletier, J, Barreto, LP, Rabelo, ILA, Agripino, JM, Tremblay, A, Bastos, MS, Protein expression and purification, 2017, 10.1016/j.pep.2016.11.004
- Identification of the catalytic subunit of the bovine lung ATP-diphosphohydrolase, Beaudoin, A. R., Picher, M., Sévigny, Jean, 1995
- Schiff bases of tryptamine as potent inhibitors of nucleoside triphosphate diphosphohydrolases (NTPDases): Structure-activity relationship, Iqbal, J, Sevigny, J, Lecka, J, Khan, H, Perveen, S, Taha, M, Wadood, A, Afzal, S, Salar, U, Mohammed Khan, K, Kanwal, Kanwal, Bioorganic chemistry, 2019, 10.1016/j.bioorg.2018.10.046
- Evaluation of sulfonate and sulfamate derivatives possessing benzofuran or benzothiophene nucleus as inhibitors of nucleotide pyrophosphatases/phosphodiesterases and anticancer agents, El-Gamal, MI, Iqbal, J, Sevigny, J, Pelletier, J, Zaib, S, Al-Rashida, M, Zaraei, SO, Ullah, S, El-Gamal, R, Anbar, HS, Bioorganic chemistry, 2020, 10.1016/j.bioorg.2020.104305
- Cloning and characterization of the ecto-nucleotidase NTPDase3 from rat brain: Predicted secondary structure and relation to other members of the E-NTPDase family and actin, Braun, N, Sevigny, J, Pelletier, J, Zimmermann, H, Vorhoff, T, Purinergic signalling, 2005, 10.1007/s11302-005-6314-x
- High expression and activity of ecto-5'-nucleotidase/CD73 in the male murine reproductive tract, Sevigny, J, Kukulski, F, Aliagas, E, Lecka, J, Fausther, M, Lavoie, EG, Martin-Satue, M, Histochemistry and cell biology, 2010, 10.1007/s00418-010-0704-z
- Expression of ecto-ATPase NTPDase2 in human dental pulp, Ren, YF, Dirksen, RT, Malmstrom, HS, Sevigny, J, Fausther, M, Pelletier, J, Wang, Q, Yu, L, Liu, X, Journal of dental research, 2012, 10.1177/0022034511431582
- Purification of pancreas type-I ATP diphosphohydrolase and identification by affinity labelling with the 5'-p-fluorosulphonylbenzoyladenosine ATP analogue, Beaudoin, AR, Côté, YP, Sévigny, J, The Biochemical journal, 1995, 10.1042/bj3120351
- A highly sensitive CE-UV method with dynamic coating of silica-fused capillaries for monitoring of nucleotide pyrophosphatase/phosphodiesterase reactions, Muller, CE, Sevigny, J, Levesque, SA, Iqbal, J, Electrophoresis, 2008, 10.1002/elps.200800013
- Expression of ecto-nucleoside triphosphate diphosphohydrolase 2 (NTPDase2) in non-myelinating Schwann cells, Zimmermann, H., Robson, S. C., Sevigny, J., Braun, N., 2001
- NUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE (NTPDASE 8) AND USES THEREOF, Jean Sévigny, 2004
- Purification, caracterisation et localisation des ATP diphosphohydrolases de mammiferes, et clonage de l'ADNc, Sevigny, Jean, 1997
- Identification of Potent and Selective Human Ecto-Nucleotide Pyrophos- phatase/Phosphodiesterase-3 (hNPP3) Inhibitors, Sévigny, J, Iqbal, J, Lecka, J, Hameed, S, Akhtar, T, Raza, R, Open Enzyme Inhibition Journal, 2011
- Cloning, purification, and identification of the liver canalicular ecto-ATPase as NTPDase8, Sevigny, J, Dranoff, JA, Zimmermann, H, Pelletier, J, Levesque, SA, Kukulski, F, Lecka, J, Fausther, M, American journal of physiology Gastrointestinal and liver physiology, 2007, 10.1152/ajpgi.00293.2006
- Assessing Ecto-5’-Nucleotidase/CD73 Expression and Malignancy Parameters in Early- and Late- Passage C6 Glioma Cells, Ana Maria O. Battastini, Fabrício Figueiró, Jean Sevigny, Guido Lenz, Maria Isabel A. Edelweiss, Leticia S. Bergamin, Elizandra Braganhol, Juliete Nathali Scholl, Luis Felipe I. Campesato, Fabiana M. Manica, Neurochemical Research, 2025, 10.1007/s11064-025-04409-8
- Attenuated allergic airway inflammation in Cd39 null mice, Baudiß, K, Robson, SC, Sevigny, J, Pelletier, J, Sorichter, S, Zech, A, Boehlke, C, Cicko, S, Vieira, RP, Grimm, M, Durk, T, Muller, T, K Ayata, C, Idzko, M, Allergy, 2013, 10.1111/all.12119
- Extracellular nucleotides mediate LPS -induced IL -8 release from monocytes and neutrophil migration., Sévigny, Jean, Lvesque, Sbastien, Lefebvre, Julie, Yebdri, Fethia Ben, Kukulski, Filip, 2006, 10.1096/fasebj.20.4.a203-be
- NUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE (NTPDASE 8) AND USES THEREOF, Jean Sévigny, 2004
- NTPDase1 controls IL-8 production by human neutrophils, Sevigny, J, Levesque, SA, Martin-Satue, M, Lecka, J, Ben Yebdri, F, Bahrami, F, Kukulski, F, Journal of immunology (Baltimore, Md : 1950), 2011, 10.4049/jimmunol.1002680
- 2-Alkoxy-3-(sulfonylarylaminomethylene)-chroman-4-ones as potent and selective inhibitors of ectonucleotidases, Iqbal, J, Hameed, A, Sevigny, J, Lecka, J, Khan, S, Ejaz, SA, Sattar, A, Batool, G, Al-Rashida, M, European journal of medicinal chemistry, 2016, 10.1016/j.ejmech.2016.02.073
- Hydrolysis of P2-purinoceptor agonists by a purified ectonucleotidase from the bovine aorta, the ATP-diphosphohydrolase, Beaudoin, AR, D'Orléans-Juste, P, Sévigny, J, Picher, M, Biochemical pharmacology, 1996, 10.1016/0006-2952(96)00086-x
- Altered lipid and salt taste responsivity in ghrelin and GOAT null mice, Maudsley, S, Martin, B, Sevigny, J, Tschop, MH, Wang, R, Daimon, CM, Cong, WN, Cai, H, PloS one, 2013, 10.1371/journal.pone.0076553
- Synthesis, characterization and biological evaluation of thiadiazole amide derivatives as nucleoside triphosphate diphosphohydrolases (NTPDases) inhibitors, Iqbal, J, Ashraf, Z, Sévigny, J, Langer, P, Hussain, D, Nadeem, H, Afzal, S, Abbas, S, Bioorganic chemistry, 2022, 10.1016/j.bioorg.2021.105456
- Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5'-carboxamide, Muller, CE, Knowles, AF, Sevigny, J, Munkonda, MN, Scheiff, AB, Umbach, F, Iqbal, J, Brunschweiger, A, Journal of medicinal chemistry, 2008, 10.1021/jm800175e
- Exacerbated intestinal inflammation in P2Y deficient mice is associated with Th17 activation, Sevigny, J, Aoudjit, F, Robaye, B, Pelletier, J, Salem, M, El Azreq, MA, Biochimica et biophysica acta Molecular basis of disease, 2019, 10.1016/j.bbadis.2019.06.019
- Erratum: Changes in expression and activity levels of ecto-5'-nucleotidase/ CD73 along the mouse female estrous cycle, Martín-Satué, M., Solsona, C., Sévigny, J., a, I., Gómez De Ar, Lavoie, E. G., Torrejón-Escribano, B., Aliagas, E., Acta Physiologica, 2010
- P2Y Receptors Regulate CXCL10 Expression and Secretion in Mouse Intestinal Epithelial Cells, Sevigny, J, Robaye, B, Pelletier, J, Tremblay, A, Salem, M, Frontiers in pharmacology, 2018, 10.3389/fphar.2018.00149
- Characterization and mutagenesis of CD39/vascular ATP diphosphohydrolase, Sévigny, Jean, 1997
- Concomitant activation of P2Y(2) and P2Y(6) receptors on monocytes is required for TLR1/2-induced neutrophil migration by regulating IL-8 secretion, Sevigny, Jean, Tremblay, Alain, Kukulski, Filip, Ben Yebdri, Fethia, European Journal of Immunology, 2009, 10.1002/EJI.200939347
- Ectonucleoside Triphosphate Diphosphohydrolase-3 Antibody Targets Adult Human Pancreatic β Cells for In Vitro and In Vivo Analysis, Powers, AC, Sevigny, J, Dai, C, Carnahan, RH, Levy, SE, Prasad, N, Shultz, LD, Greiner, DL, Dean, ED, Shostak, A, Virostko, J, Goff, MT, Cooper, T, Pelletier, J, Weller, KP, Flaherty, DK, Poffenberger, G, la, R, Aram, Walker, JT, Shrestha, S, Phillips, N, Brissova, M, Saunders, DC, Cell metabolism, 2019, 10.1016/j.cmet.2018.10.007
- The endothelial P2Y2 receptor mediates LPS-induced neutrophil transendothelial migration, Sevigny, Jean, Tremblay, Alain, Fausther, Michel, Ben Yebdri, Fethia, Kukulski, Filip, 2008
- The ecto-nucleoside triphosphate diphosphohydrolase NTPDase2/CD39L1 is expressed in a novel functional compartment within the liver, Sévigny, J, Zimmermann, H, Braun, N, Robson, SC, Kruglov, EA, Dranoff, JA, Hepatology (Baltimore, Md ), 2002, 10.1053/jhep.2002.36823
- HIGHLY SELECTIVE AND POTENT NPP1 INHIBITORS BASED ON URIDINE-5'-P,-DITHIOPHOSPHATE ANALOGUES, Muller, Christa, Arad Uri, Moshe, Zelikman, Vadim, Nassir, Molhm, Fischer Hana, Bilha, Jean Sévigny, 2020
- The ectonucleoside triphosphate diphosphohydrolase-2 (NTPDase2) in human endometrium: a novel marker of basal stroma and mesenchymal stem cells, Martin-Satue, M, Matias-Guiu, X, Coroleu, B, Ponce, J, Sevigny, J, Rodriguez-Martinez, A, Vidal, A, Trapero, C, Purinergic signalling, 2019, 10.1007/s11302-019-09656-3
- P2Y(6) nucleotide receptor mediates monocyte interleukin-8 production in response to UDP or lipopolysaccharide, Kelly, CP, Soltoff, SP, Communi, D, Sévigny, J, Robson, SC, Aboudola, S, Warny, M, The Journal of biological chemistry, 2001, 10.1074/jbc.M102568200
- Chemoselective Synthesis and Human Ecto‐5′‐nucleotidase Inhibitory Activity of 2‐Trifluoromethyl‐4,6‐diarylquinolines, Langer, P, Iqbal, J, Rodríguez, ET, Sévigny, J, Lecka, J, Ehlers, P, Hassan, S, Rivera, RP, ChemistrySelect, 2018, 10.1002/slct.201800917
- METHOD OF REDUCING ANGIOGENESIS, Hoshi, Tomokazu, Sundberg, Christian, Robson Simon, C., Jean Sévigny, 2003
- Identification and isolation of a novel liver cell type expressing the ecto-nucleotidase NTPDase 2, Zimmerman, H., Braun, N., Robson, S. C., Sevigny, J., Kruglov, E. A., Dranoff, J. A., 2002
- Expression of NTPDase1 and NTPDase2 in murine kidney: relevance to regulation of P2 receptor signaling, Robson, SC, Sevigny, J, Zimmermann, H, Braun, N, Gill, PS, Shi, H, Tripp, SR, Fausther, M, Isaac, J, Kishore, BK, American journal of physiology Renal physiology, 2005, 10.1152/ajprenal.00108.2004
- NTPDASE1 (CD39) regulates extracellular nuclecitides-induced vasomotion, Sevigny, J., Kauffenstein, G., 2007
- Targeted disruption of cd73/ecto-5'-nucleotidase alters thromboregulation and augments vascular inflammatory response, Schrader, J, Gödecke, A, Zimmermann, H, Ley, K, Weber, C, Ding, Z, Molojavyi, A, Weber, AA, Gear, A, Sevigny, J, Smith, ML, Decking, UK, Buchheiser, A, Braun, N, Flögel, U, Zernecke, A, Huo, Y, Ozüyaman, B, Koszalka, P, Circulation research, 2004, 10.1161/01.RES.0000144796.82787.6f
- Synthesis of novel ()-1-(2-(2-(4(dimethylamino) benzylidene) hydrazinyl)-4-methylthiazol-5-yl)ethanone derivatives as ecto-5'-nucleotidase inhibitors, Iqbal, J, Sevigny, J, Lecka, J, Shah, HS, Saeed, A, Larik, FA, Channar, PA, Hassan, S, Royal Society open science, 2018, 10.1098/rsos.180837
- Loss of vascular expression of nucleoside triphosphate diphosphohydrolase-1/CD39 in hypertension, Kauffenstein, G, Henrion, D, Sevigny, J, Robson, SC, Ryffel, B, Nascimento, DC, Martin, L, Guihot, AL, Favre, J, Merot, J, Delneste, Y, Caillon, A, Tabiasco, J, Roy, C, Purinergic signalling, 2018, 10.1007/s11302-017-9597-9
- NTPDase2 is necessary for regulation of bile duct epithelial proliferation by portal fibroblasts, Sevigny, Jean, Kruglov, Emma A., ier, Muhammad N., Jh, Dranoff, Jonathan A., 2004
- Generation and Characterization of Specific Antibodies to the Murine and Human Ectonucleotidase NTPDase8, Sevigny, J, Bigonnesse, F, Fausther, M, Lecka, J, Salem, M, Pelletier, J, Frontiers in pharmacology, 2017, 10.3389/fphar.2017.00115
- Diadenosine and diuridine poly(borano)phosphate analogues: synthesis, chemical and enzymatic stability, and activity at P2Y1 and P2Y2 receptors, Fischer, B, Reiser, G, Sévigny, J, Lévesque, SA, Tulapurkar, M, Nahum, V, Journal of medicinal chemistry, 2006, 10.1021/jm050955y
- Neutrophils: fast and furious-the nucleotide pathway, Braganhol, E, Sevigny, J, Lenz, GS, Omizzollo, N, de Souza, PO, Rubenich, DS, Purinergic signalling, 2021, 10.1007/s11302-021-09786-7
- Immunocytochemical localization of NTPDases1 and 2 in the neural retina of mouse and zebrafish, Faillace, MP, Schwarzbaum, PJ, Sevigny, J, Lavoie, EG, Alfie, LD, Ricatti, MJ, Synapse (New York, N Y ), 2009, 10.1002/syn.20605
- Regulation of liver fibrosis by P2Y nucleotide receptors, Wells, R. G., Gaca, M., Robson, S. C., Sevigny, J., Kruglov, E. A., Dranoff, J. A., 2004
- Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplants, Soares, MP, Bach, FH, Choi, AM, Vercellotti, G, Robson, SC, Sevigny, J, Csizmadia, E, Lin, Y, Brouard, S, Smith, RN, Otterbein, L, Balla, J, Sato, K, The Journal of Immunology, 2001, 10.4049/JIMMUNOL.166.6.4185
- Dual role of P2Y6 receptors in the human urinary bladder: On the role of ATP released from the urothelium, Correia-de-S, Paulo, Sévigny, Jean, Silva-Ramos, Miguel, Ferreirinha, Ftima, Correia, Joana, rina, Timteo, M. Alex, Silva, Isabel, 2013, 10.1016/j.autneu.2013.08.021
- Distribution of ecto-nucleotidases in mouse sensory circuits suggests roles for nucleoside triphosphate diphosphohydrolase-3 in nociception and mechanoreception, Molliver, DC, Sevigny, J, Lavoie, EG, Vongtau, HO, Neuroscience, 2011, 10.1016/j.neuroscience.2011.07.044
- Modulation of nucleoside [correction of nucleotide] triphosphate diphosphohydrolase-1 (NTPDase-1)cd39 in xenograft rejection, Robson, SC, Bach, FH, Rosenberg, RD, Sévigny, J, Csizmadia, E, Lin, Y, Smith, RN, Enjyoji, K, Guckelberger, O, Imai, M, Takigami, K, Molecular medicine (Cambridge, Mass ), 1999
- Resistance training reduces platelet activation in hypertensive women: the role of purinergic signaling, Clodoaldo Antônio De Sá, Vanessa da Silva Corralo, Jean Sévigny, Sarah Franco Vieira de Oliveira Maciel, Daniela Zanini, Aline Mânica, Mônica Lammers, Nyasmin Mendes Aneli, Andréia Machado Cardoso, Journal of Hypertension, 2023, 10.1097/hjh.0000000000003529
- Synthesis of Thieno[3,2-d]pyrimidine Derivatives through Sequential SNAr and Suzuki Reactions as Selective h-NTPDases Inhibitors, Abbas Hassan, Jamshed Iqbal, Jean Sévigny, Julia Pelletier, Farman Ullah, Haseen Ahmad, Sania Batool, Muhammad Uzair, Saif Ullah, Gohar Zaman, ChemMedChem, 2023, 10.1002/cmdc.202300165
- Nonhydrolyzable ATP analogues as selective inhibitors of human NPP1: a combined computational/experimental study, Sevigny, J, Senderowitz, H, Fischer, B, Pelletier, J, Luyindula, P, Oscar, Jr, Eliahu, S, Simhaev, L, Ben-David, G, Lecka, J, Journal of medicinal chemistry, 2013, 10.1021/jm400918s
- Highly Potent and Selective Ectonucleoside Triphosphate Diphosphohydrolase (ENTPDase1, 2, 3 and 8) Inhibitors Having 2-substituted-7- trifluoromethyl-thiadiazolopyrimidones Scaffold, Iqbal, J, Sevigny, J, Lecka, J, Langer, P, Jafari, B, Zaib, S, Afzal, S, Medicinal chemistry (Shariqah (United Arab Emirates)), 2020, 10.2174/1573406415666190614095821
- Nucleoside triphosphate diphosphohydrolase-1 ectonucleotidase is required for normal vas deferens contraction and male fertility through maintaining P2X1 receptor function, Sevigny, J, Vial, C, Sullivan, R, Henrion, D, Toutain, B, Sereda, MJ, Ribas Furstenau, C, Frenette, J, Dufresne, SS, Martin-Satue, M, Kukulski, F, Lavoie, EG, Pelletier, J, Kauffenstein, G, The Journal of biological chemistry, 2014, 10.1074/jbc.M114.604082
- Physical exercise prevents memory impairment in an animal model of hypertension through modulation of CD39 and CD73 activities and A2A receptor expression, Schetinger, MRC, Sevigny, J, Morsch, VM, Rubin, MA, Bello-Klein, A, Tremblay, A, Carvalho, F, Gutierres, JM, Bagatini, MD, Zanini, D, Manfredi, LH, Cardoso, AM, Journal of hypertension, 2019, 10.1097/HJH.0000000000001845
- P2Y(6)-induced release of ATP from the urothelium exerts a dual role in the human urinary bladder, Correia-de-Sa, P., Sevigny, J., Silva-Ramos, M., Ferreirinha, F., Correia, J., Silva, I., The FEBS Journal, 2013
- Transforming growth factor-beta and substrate stiffness regulate portal fibroblast activation in culture, Wells, Rebecca G., Sevigny, Jean, Uemura, Masayuki, Chan, Erick P., Dranoff, Jonathan A., Li, Zhaodong, Hepatology, 2007, 10.1002/HEP.21792
- 4-Aminopyridine based amide derivatives as dual inhibitors of tissue non-specific alkaline phosphatase and ecto-5'-nucleotidase with potential anticancer activity, Iqbal, J, Shabir, G, Sevigny, J, Lecka, J, Ullah Khan, S, Shehzad, M, Saeed, A, Ejaz, SA, Hassan, S, Bioorganic chemistry, 2018, 10.1016/j.bioorg.2017.11.013
- Structural elements and limited proteolysis of CD39 influence ATP diphosphohydrolase activity, Robson, SC, Beaudoin, AR, Koziak, K, Imai, M, Siegel, JB, Kaczmarek, E, Sévigny, J, Schulte am Esch, J, Biochemistry, 1999, 10.1021/bi982426k
- Characterization of a novel E-NTPDase, Lemmens, R., Csizmadia, E., Beaudoin, A. R., Robson, S. C., Sévigny, J., Ecto-ATPases and related ectonucleotidases : proceedings of the Second International Workshop on Ecto-ATPases and Related Ecotonucleotidases, held in Diepenbeek, Belgium, June 14-18, 1999, 1999
- Immortalization of Mesenchymal Stromal Cells by TERT Affects Adenosine Metabolism and Impairs their Immunosuppressive Capacity, Wink, MR, Lenz, G, Sévigny, J, Bertoni, APS, Iser, IC, de Campos, RP, Onzi, GR, Korb, VG, da Fontoura, DMS, Beckenkamp, LR, Stem cell reviews and reports, 2020, 10.1007/s12015-020-09986-5
- Reduced striatal ecto-nucleotidase activity in schizophrenia patients supports the "adenosine hypothesis", Barrachina, M, Martin-Satue, M, Ferrer, I, Romeu, M, Roca, M, Sevigny, J, Villar-Menendez, I, Aliagas, E, Purinergic signalling, 2013, 10.1007/s11302-013-9370-7
- Cloning and characterization of mouse nucleoside triphosphate diphosphohydrolase-3, Sévigny, J, Lecka, J, Lévesque, SA, Kukulski, F, Lavoie, EG, Biochemical pharmacology, 2004, 10.1016/j.bcp.2004.02.012
- Ectonucleotidase Inhibitory and Redox Activity of Imidazole‐Based Organic Salts and Ionic Liquids, Fliur Macaev, Denis Prodius, Jean Sévigny, Joanna Lecka, Mariana Neamtu, Jamshed Iqbal, Sidra Hassan, Natalia Sucman, Veaceslav Boldescu, ChemMedChem, 2018, 10.1002/cmdc.201800520
- The ecto-ATPase NTPDase2 is expressed by astrocytic type-B cells of the adult neurogenic subventricular zone and in germinal zones of the developing rat brain, Zimmermann, H., Hammer, K., Gerstberger, R., Barth, S. W., Robson, S. C., Mishra, S. K., Sevigny, J., Braun, N., 2003
- Endometrial epithelial cell organoids as tools for studying the CD39 family of enzymes and for validating enzyme inhibitors., Martín-Satué M, Matias-Guiu X, Sévigny J, Gabaldón C, Dorca-Arévalo J, Eritja N, Torrejón-Escribano B, Rodríguez-Martínez A, Histology and histopathology, 2024, 10.14670/hh-18-782
- Opposing Effects of Adenosine and Inosine in Human Subcutaneous Fibroblasts May Be Regulated by Third Party ADA Cell Providers, Correia-de-Sa, P, Sevigny, J, Pelletier, J, Ribeiro, S, Magalhaes-Cardoso, T, Ferreirinha, F, Costa, MA, Paramos-de-Carvalho, D, Pinheiro, AR, Herman-de-Sousa, C, Cells, 2020, 10.3390/cells9030651
- Nucleoside triphosphate diphosphohydrolases role in the pathophysiology of cognitive impairment induced by seizure in early age, Bonan, CD, Sevigny, J, Souza, DO, Bogo, MR, Casali, E, Bellaver, B, Savio, LE, Vuaden, FC, Cognato, GD, Neuroscience, 2011, 10.1016/j.neuroscience.2011.01.065
- Homocysteine modifies extracellular ATP availability in macrophages, Oliveira Battastini, Ana Maria, de Souza Wyse, Angela Terezinha, Sevigny, Jean, Braganhol, Elizandra, Bergamin, Leticia Scussel, Zanin, Rafael Fernandes, Toxicology in Vitro, 2013, 10.1016/J.TIV.2013.09.001
- Editorial: Metalloenzymes: Potential Drug Targets, Sévigny, J, Jacob, C, Iqbal, J, Frontiers in pharmacology, 2021, 10.3389/fphar.2021.746925
- Deazapurine Analogues Bearing a 1H-Pyrazolo[3,4-b]pyridin- 3(2H)-one Core: Synthesis and Biological Activity, Langer, P, Iqbal, J, Sévigny, J, Lecka, J, Iaroshenko, VO, Hein, M, Ejaz, SA, Mahmood, A, Afzal, S, European journal of organic chemistry, 2018, 10.1002/ejoc.201800163
- Changes in ecto-nucleotidases in murine and human endometria along the female cycle, Martin Satue, Mireia, Sevigny, J., Torrejon-Escribano, B., Lavoie, E. G., Ponce, J., Vidal, A., Taco-Sanchez, M. R., Aliagas Marin, Elisabet, 2010
- Erratum to: 17β-Estradiol-Induced Synaptic Rearrangements Are Accompanied by Altered Ectonucleotidase Activities in Male Rat Hippocampal Synaptosomes, Grkovic, I, Nedeljkovic, N, Stanojlovic, M, Sevigny, J, Martinovic, J, Zaric, M, Drakulic, D, Mitrovic, N, Journal of molecular neuroscience : MN, 2017, 10.1007/s12031-016-0879-4
- IL-6 downregulates transcription of NTPDase2 via specific promoter elements, Dranoff, JA, Sevigny, J, Tremblay, JJ, Sheung, N, Lavoie, EG, Yu, J, American journal of physiology Gastrointestinal and liver physiology, 2008, 10.1152/ajpgi.00208.2007
- Identification of small molecule sulfonic acids as ecto-5'-Nucleotidase inhibitors, Iqbal, J, Sevigny, J, Lecka, J, Saeed, A, Raza, R, Medicinal chemistry (Shariqah (United Arab Emirates)), 2012, 10.2174/1573406411208061133
- Exploration of carboxy pyrazole derivatives: Synthesis, alkaline phosphatase, nucleotide pyrophosphatase/phosphodiesterase and nucleoside triphosphate diphosphohydrolase inhibition studies with potential anticancer profile, Iqbal, J, Erben, MF, Sevigny, J, Lecka, J, Mahesar, PA, Larik, FA, Saeed, A, Ejaz, SA, Afzal, S, Channar, PA, European journal of medicinal chemistry, 2018, 10.1016/j.ejmech.2018.07.002
- Synthesis and computational studies of highly selective inhibitors of human recombinant tissue non-specific alkaline phosphatase (h-TNAP): A therapeutic target against vascular calcification, Hameed, S, Iqbal, J, Zhang, J, Yasinzai, M, Farman, M, Sevigny, J, Abida Ejaz, S, Hussain, M, Andleeb, H, Bioorganic chemistry, 2020, 10.1016/j.bioorg.2020.103999
- Isonicotinohydrazones as inhibitors of alkaline phosphatase and ecto-5'-nucleotidase, Iqbal, J, Saeed, A, Bajorath, J, Sevigny, J, Lecka, J, Nisa, ZU, Hassan, S, Shah, SJ, Channar, PA, Chemical biology & drug design, 2017, 10.1111/cbdd.12861
- Nasal Administration of Cationic Nanoemulsions as CD73-siRNA Delivery System for Glioblastoma Treatment: a New Therapeutical Approach, Braganhol, E, Teixeira, HF, Battastini, AMO, Stefani, MA, Sevigny, J, Wink, MR, daCosta, JC, Greggio, S, Venturin, G, Lenz, GS, de Oliveira, FH, Iser, IC, Beckenkamp, LR, Gelsleichter, NE, Michels, LR, Schuh, RS, Azambuja, JH, Molecular neurobiology, 2020, 10.1007/s12035-019-01730-6
- Novel and specific inhibitors of ectonucleotidases, Fischer, Bilha, Sevigny, Jean, Munkonda, Mercedes, Lecka, Joanna, Gillerman, Irina, 2008
- The ecto-nucleotidase NTPDase1 differentially regulates P2Y1 and P2Y2 receptor-dependent vasorelaxation, Sevigny, J, D'Orleans-Juste, P, Furstenau, CR, Kauffenstein, G, British journal of pharmacology, 2010, 10.1111/j.1476-5381.2009.00566.x
- NTPDase3 is the principal ectonucleotidase in both nociceptors and low threshold mechanoreceptors, Molliver, D. C., Sevigny, J., Lavoie, E. G., Vongtau, H. O., 2011
- Involvement of purinergic system in the release of cytokines by macrophages exposed to glioma-conditioned medium, Battastini, AM, Sevigny, J, Zanin, RF, Casali, E, Figueiro, F, Braganhol, E, Bergamin, LS, Journal of cellular biochemistry, 2015, 10.1002/jcb.25018
- Probing the high potency of pyrazolyl pyrimidinetriones and thioxopyrimidinediones as selective and efficient non-nucleotide inhibitors of recombinant human ectonucleotidases, Iqbal, J, Sevigny, J, Lecka, J, Zaib, S, Khan, I, Ejaz, SA, Hameed, S, Andleeb, H, Bioorganic chemistry, 2019, 10.1016/j.bioorg.2019.03.067
- Overexpression of NTPDase2 in gliomas promotes systemic inflammation and pulmonary injury, Battastini, AM, Robson, SC, Sevigny, J, Wink, MR, Edelweiss, MI, Calixto, JB, Campos, MM, Morrone, FB, Campesato, LF, Cappellari, AR, Bergamin, LS, Bernardi, A, Zanin, RF, Braganhol, E, Purinergic signalling, 2012, 10.1007/s11302-011-9276-1
- Identification and characterization of CD39/vascular ATP diphosphohydrolase, Robson, SC, Bach, FH, Beaudoin, AR, Anrather, J, Siegel, JB, Sévigny, J, Koziak, K, Kaczmarek, E, The Journal of biological chemistry, 1996, 10.1074/jbc.271.51.33116
- Purification, characterization, and localization of an ATP diphosphohydrolase in porcine kidney, uffel, L, V, Waelkens, E, Kittel, A, Grondin, G, Beaudoin, AR, Sévigny, J, Kupers, L, Lemmens, R, American journal of physiology Renal physiology, 2000, 10.1152/ajprenal.2000.278.6.F978
- Nucleotide receptors control IL-8/CXCL8 and MCP-1/CCL2 secretions as well as proliferation in human glioma cells, Ben Yebdri, F, Sevigny, J, Battastini, AM, Fonseca Moreira, JC, Bahrami, F, Pelletier, J, Bergamin, LS, Zanotto-Filho, A, Lavoie, EG, Fausther, M, Levesque, SA, Kukulski, F, Braganhol, E, Biochimica et biophysica acta, 2015, 10.1016/j.bbadis.2014.10.014
- Blockade of P2Y receptors prevents cirrhosis due to carbon tetrachloride but not extrahepatic bile duct ligation, Sevigny, Jean, Robson, Simon, Kruglov, Emma A., Dranoff, Jonathan A., 2004
- Synthesis, characterization, alkaline phosphatase inhibition assay and molecular modeling studies of 1-benzylidene-2-(4-tert- butylthiazol-2-yl) hydrazines, Iqbal, J, Sévigny, J, Pelletier, J, El-Seedi, HR, Saeed, A, Zaib, S, Mahmood, A, Aziz, H, Journal of biomolecular structure & dynamics, 2021, 10.1080/07391102.2020.1802336
- Localization of the ecto-NTPDases in the murine reproductive tract, Sevigny, Jean, Robson, Simon C., Guckelberger, Olaf, Czismadia, Eva, Fausther, Michel, Pelletier, Julie, Lavoie, Elise G., Martin-Satue, Mireia, 2008
- Regional and sex-related differences in modulating effects of female sex steroids on ecto-5'-nucleotidase expression in the rat cerebral cortex and hippocampus, Grkovic, I, Nedeljkovic, N, Horvat, A, Sevigny, J, Zlatkovic, J, Stanojlovic, M, Drakulic, D, Gusevac, I, Mitrovic, N, General and comparative endocrinology, 2016, 10.1016/j.ygcen.2016.06.018
- CD39 ist ein kritischer Modulator der Thrombozytenund Endothelzellaktivierung nach Ischämie-Reperfusion, S. C. Robson, P. Neuhaus, E. Kaczmarek, K. Enjyoji, J. B. Kruskal, M. Imai, J. Sévigny, O. Guckelberger, Deutsche Gesellschaft für Chirurgie, 2001, 10.1007/978-3-642-56698-1_79
- Induction of NTPDase1/CD39 by Reactive Microglia and Macrophages Is Associated With the Functional State During EAE, Laketa, D, Nedeljkovic, N, Pekovic, S, Sevigny, J, Savic, D, Bjelobaba, I, Milosevic, A, Bozic, I, Lavrnja, I, Jakovljevic, M, Frontiers in neuroscience, 2019, 10.3389/fnins.2019.00410
- Synthesis, in vitro, and in silico studies of morpholine-based thiosemicarbazones as ectonucleotide pyrophosphatase/phosphodiesterase-1 and -3 inhibitors., Iqbal J, Shafiq Z, Negm S, Taslimi P, El-Kott AF, Al-Harrasi A, Ajmal M, Hussain Z, Sévigny J, Pelletier J, Tasleem M, International journal of biological macromolecules, 2024, 10.1016/j.ijbiomac.2024.131068
- 17β-Estradiol upregulates ecto-5'-nucleotidase (CD73) in hippocampal synaptosomes of female rats through action mediated by estrogen receptor-α and -β, Grkovic, I, Nedeljkovic, N, Horvat, A, Sevigny, J, Stanojlovic, M, Martinovic, J, Drakulic, D, Zaric, M, Mitrovic, N, Neuroscience, 2016, 10.1016/j.neuroscience.2016.03.022
- Changes in ecto-nucleotidases in murine and human endometria along the female cycle, Martin Satue, Mireia, Sevigny, J., Torrejon-Escribano, B., Lavoie, E. G., Ponce, J., Vidal, A., Taco-Sanchez, M. R., Aliagas Marin, Elisabet, Purinergic Signalling, 2010
- Characterization of a novel ATP diphosphohydrolase/CD39-like protein, Sévigny, Jean, 1999
- Synthesis, biological evaluation, and docking studies of novel pyrrolo[2,3-b]pyridine derivatives as both ectonucleotide pyrophosphatase/phosphodiesterase inhibitors and antiproliferative agents, Iqbal, J, Anbar, HS, Shehata, MK, Sevigny, J, Pelletier, J, El-Gamal, R, El-Gamal, MI, Ullah, S, European journal of medicinal chemistry, 2021, 10.1016/j.ejmech.2021.113339
- Generation and characterization of a monoclonal antibody as the first specific inhibitor of human NTPDase3, Sevigny, Jean, Kirley, Terence, Kuenzli, Beat, Tremblay, Alain, Pelletier, Julie, Ivanenkov, Vasily, Fausther, Michel, Munkonda, Mercedes, 2008
- Is Failure to Regulate Neutrophil Recruitment in Cystic Fibrosis Caused by the Loss of Airway Ntpdasei?, Sevigny, J., Boucher, R. C., Ribeiro, C. M., Pelletier, J., Fausther, M., Picher, M., 2009
- 1. Role d'un HTF dans la replication. 2. Role de c-myc dans la recombinaison, Sevigny, Jean, 1992
- CD39 is a caveolar-associated ectonucleotidase, Sévigny, Jean, 1999
- Distinctive inhibition of alkaline phosphatase isozymes by thiazol-2-ylidene-benzamide derivatives: Functional insights into their anticancer role, Iqbal, J, Sevigny, J, Lecka, J, Hameed, A, Shah, SJA, Saeed, A, Ejaz, SA, Journal of cellular biochemistry, 2018, 10.1002/jcb.26692
- Epitope mapping in cell surface proteins by site-directed masking: defining the structural elements of NTPDase3 inhibition by a monoclonal antibody, Kirley, TL, Sevigny, J, Toyama, A, Crawford, PA, Ivanenkov, VV, Protein engineering, design & selection : PEDS, 2010, 10.1093/protein/gzq027
- Specificity of the ecto-ATPase inhibitor ARL 67156 on human and mouse ectonucleotidases, Sevigny, J, Bigonnesse, F, Lecka, J, Lavoie, EG, Levesque, SA, British journal of pharmacology, 2007, 10.1038/sj.bjp.0707361
- Hydrolytically stable and selective P2Y(1/6) receptor agonists, Reiser, Georg, Sevigny, Jean, Lecka, Joanna, Weisman, Gary, Camden, Jean, Nahum, Vicky, Yelovitch, Shir, Eliahu, Shay E., Fischer, Bilha, 2008
- NUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE (NTPDASE 8) AND USES THEREOF, Jean Sévigny, 2004
- Distribution of ectonucleoside triphosphate diphosphohydrolases 1 and 2 in rat cochlea, Housley, GD, Robson, SC, Sevigny, J, Thorne, PR, Vlajkovic, SM, Hearing Research, 2002, 10.1016/S0378-5955(02)00460-4
- ATP-diphosphohydrolases, apyrases, and nucleotide phosphohydrolases: Biochemical properties and functions, Picher, M., Sévigny, J., Beaudoin, A. R., Biomembranes: A Multi-Volume Treatise, volume 5 : ATPases, 1996, 10.1016/S1874-5342(06)80015-2
- Synthesis and biological evaluation of sulfamoyl benzamide derivatives as selective inhibitors for h-NTPDases, Abbas Hassan, Jamshed Iqbal, Jean Sévigny, Julie Pelletier, Saif Ullah, Zahid Hussain Zaigham, RSC Advances, 2023, 10.1039/D3RA03874B
- Sequencing, cloning and expression of porcine cd39, uffel, L., V, Sévigny, J., Kittel, A., Lemmens, R. A., Ecto-ATPases and related ectonucleotidases : proceedings of the Second International Workshop on Ecto-ATPases and Related Ecotonucleotidases, held in Diepenbeek, Belgium, June 14-18, 1999, 1999
- Regulatory T Cells Negatively Affect IL-2 Production of Effector T Cells through CD39/Adenosine Pathway in HIV Infection, Levy, Yves, Lelievre, Jean-Daniel, Sevigny, Jean, Tremblay, Alain, Routy, Jean-Pierre, Koek, Ayrin, Ghadimi, Elnaz, Younas, Mehwish, Hulin, Anne, Carriere, Matthieu, Yatim, Ahmad, Seddiki, Nabila, Jenabian, Mohammad-Ali, PLOS Pathogens, 2013, 10.1371/JOURNAL.PPAT.1003319
- Localization of CD39/vascular NTP diphosphohydrolase (NTPDase) in rat kidney, Robson, S. C., Sevigny, J., Tripp, S. R., Isaac, J., Kishore, B. K., 2002
- Differential catalytic properties and vascular topography of murine nucleoside triphosphate diphosphohydrolase 1 (NTPDase1) and NTPDase2 have implications for thromboregulation, Robson, SC, Zimmermann, H, Imai, M, Qawi, I, Csizmadia, E, Guckelberger, O, Braun, N, Sundberg, C, Sévigny, J, Blood, 2002, 10.1182/blood.v99.8.2801
- Purification and identification by immunological techniques of different isoforms of mammalian ATP diphosphohydrolases, Beaudoin, A. R., Dumas, F., Sevigny, J., Ecto-ATPases : recent progress on structure and function : [proceedings of the First International workshop on ecto-ATPases, held August 26-30, 1996, in Mar de Plata, Argentina], 1996, 10.1007/978-1-4615-5955-9_18
- The molecular and functional properties of E-NTPDasex/1, E-NTPDase2 and ecto-5’-nucleotidase in nervous tissue, Robson, S. C., Sévigny, J., Marxen, M., Kohring, K., Heine, P., Braun, N., Zimmermann, H., Ecto-ATPases and related ectonucleotidases : proceedings of the Second International Workshop on Ecto-ATPases and Related Ecotonucleotidases, held in Diepenbeek, Belgium, June 14-18, 1999, 1999
- Extracellular ectonucleotidases are differentially regulated in murine tissues and human polymorphonuclear leukocytes during sepsis and inflammation, Haskó, G, Braganhol, E, Németh, Z, Sévigny, J, Leite, RO, Pelletier, J, de Souza, PO, Pacher, P, Lovászi, M, Haas, CB, Purinergic signalling, 2021, 10.1007/s11302-021-09819-1
- Divergent synthesis and elaboration of structure activity relationship for quinoline derivatives as highly selective NTPDase inhibitor, Hassan, A, Iqbal, J, Sévigny, J, Pelletier, J, Saeed, A, Zaman, G, Afzal, S, Murtaza, A, Bioorganic chemistry, 2021, 10.1016/j.bioorg.2021.105240
- Inhibition of ATPDase/CD30 in human vascular endothelial cells by antisense oligonucleotides, Sévigny, Jean, 1999
- Trafficking and intracellular ATPase activity of human ecto-nucleotidase NTPDase3 and the effect of ER-targeted NTPDase3 on protein folding, Kirley, TL, Sevigny, J, Ivanenkov, VV, Biochemistry, 2008, 10.1021/bi800402q
- Cochlear distribution of NTPDase1 and 2., Housley, Gary D., Robson, Simon C., Sevigny, Jean, Thorne, Peter R., Vlajkovic, Srdjan M., 2002
- Expression of P2Y nucleotide receptors and ectonucleotidases in quiescent and activated rat hepatic stellate cells, Wells, RG, Robson, SC, Sevigny, J, Gaca, MD, Kruglov, EA, Ogawa, M, Dranoff, JA, American journal of physiology Gastrointestinal and liver physiology, 2004, 10.1152/ajpgi.00294.2003
- 8-BuS-ATP derivatives as specific NTPDase1 inhibitors, Sevigny, J, Fischer, B, Kunzli, B, Poirier, D, Rousseau, E, d'Orleans-Juste, P, Martin-Satue, M, Cadot, C, Brosseau, JP, Munkonda, MN, Salem, M, Fausther, M, Gillerman, I, Lecka, J, British journal of pharmacology, 2013, 10.1111/bph.12135
- Ecto-5'-nucleotidase (CD73)-mediated formation of adenosine is critical for the striatal adenosine A2A receptor functions, Chen, JF, Cunha, RA, Muller, CE, Bynoe, MS, El-Tayeb, A, Sevigny, J, Matos, M, Augusto, E, The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, 10.1523/JNEUROSCI.5817-12.2013
- Sulfated Polysaccharides from Macroalgae Are Potent Dual Inhibitors of Human ATP-Hydrolyzing Ectonucleotidases NPP1 and CD39, Muller, CE, Bendas, G, Alban, S, Sevigny, J, Lee, SY, Pelletier, J, Renn, C, Mirza, S, Schmidt, MS, Schuh, HJM, Schakel, L, Lopez, V, Marine drugs, 2021, 10.3390/md19020051
- NTPDase1 (cd39) regulates extracellular nucleotides-induced vasomotion, Sevigny, J., Kauffenstein, G., 2008
- Erratum: Comparative hydrolysis of P2 receptor agonists by NTPDases 1, 2, 3 and 8. (Purinergic Signalling (2005) vol. 1 (2) (193-204)), Sevigny, J., Kirley, T. L., Robson, S. C., Knowles, A. F., Bigonnesse, F., Lecka, J., Lavoie, E. G., Levesque, S. A., Kukulski, F., Purinergic Signalling, 2005
- Polyoxometalates--potent and selective ecto-nucleotidase inhibitors, Muller, CE, Stephan, H, Kortz, U, Sevigny, J, Zimmermann, H, Pietzsch, HJ, Haider, A, Lecka, J, Fedorov, VE, Brylev, KA, Hanck, T, Li, W, Fiene, A, Lee, SY, Biochemical pharmacology, 2015, 10.1016/j.bcp.2014.11.002
- Identification and Expression Analysis of CD73 Inhibitors in Cervical Cancer, Sévigny, J, Pelletier, J, Abid, SMA, Bano, S, Basharat, A, Iqbal, J, Medicinal chemistry (Shariqah (United Arab Emirates)), 2021, 10.2174/1573406416666200925141703
- Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation, Rosenberg, RD, Robson, SC, Wagner, DD, Csizmadia, E, Beeler, DL, Lech, M, Rayburn, H, Edelberg, JM, Imai, M, Esch, JS, Christie, PD, Frenette, PS, Lin, Y, Sévigny, J, Enjyoji, K, Nature medicine, 1999, 10.1038/12447
- Distinct roles of ecto-nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) in liver regeneration and fibrosis, Robson, SC, Popov, YV, Schmelzle, M, Sevigny, J, Vaid, KA, Rothweiler, S, Yee, EU, Tran, S, Mitsuhashi, S, Csizmadia, E, Jiang, ZG, Feldbrugge, L, Purinergic signalling, 2018, 10.1007/s11302-017-9590-3
- NTPDase1 governs P2X7-dependent functions in murine macrophages, Sevigny, J, Robson, SC, Enjyoji, K, Kukulski, F, Levesque, SA, European journal of immunology, 2010, 10.1002/eji.200939741
- Influence of the diversified structural variations at the imine functionality of 4-bromophenylacetic acid derived hydrazones on alkaline phosphatase inhibition: synthesis and molecular modelling studies, Iqbal, J, Sévigny, J, Lecka, J, Simpson, J, Hameed, S, Ali Shah, SJ, Khan, SU, Ejaz, SA, Ibrar, A, Khan, I, RSC advances, 2015, 10.1039/c5ra14836g
- Highly Selective and Potent Ectonucleotide Pyrophosphatase-1 (NPP1) Inhibitors Based on Uridine 5'-P-Dithiophosphate Analogues, Fischer, B, Sevigny, J, Senderowitz, H, Arguin, G, Gendron, FP, Sela, A, Simhaev, L, Pelletier, J, Zelikman, V, Journal of medicinal chemistry, 2018, 10.1021/acs.jmedchem.7b01906
- A domino reaction of 3-chlorochromones with aminoheterocycles. Synthesis of pyrazolopyridines and benzofuropyridines and their optical and ecto-5'-nucleotidase inhibitory effects, Langer, P, Lochbrunner, S, Friedrich, A, Villinger, A, Sevigny, J, Lecka, J, Iqbal, J, Zaib, S, Hassan, S, Janke, J, Miliutina, M, Organic & biomolecular chemistry, 2018, 10.1039/c7ob02729j
- The anti-inflammatory effect of resistance training in hypertensive women: the role of purinergic signaling, Cardoso, AM, Manfredi, LH, De Sa, CA, Sevigny, J, Bagatini, MD, de Resende E Silva, DT, Manica, A, Zanini, D, de Oliveira Maciel, SFV, de Oliveira, GG, Aneli, NM, Lammers, MD, Journal of hypertension, 2020, 10.1097/HJH.0000000000002578
- Cloning of the hepatic canalicular ecto-atpase: Identification as a novel nucleoside triphosphate diphosphohydrolase., Sévigny, Jean, 2002
- Regulation of liver fibrosis by P2Y nucleotide receptors, Wells, R. G., Gaca, M., Robson, S. C., Sevigny, J., Kruglov, E. A., Dranoff, J. A., 2004
- CD39 as a caveolar-associated ectonucleotidase, Robson, SC, Csizmadia, E, Lengyel, K, Sevigny, J, Kaczmarek, E, Kittel, A, Biochemical and biophysical research communications, 1999, 10.1006/bbrc.1999.1254
- Rat submandibular glands secrete nanovesicles with NTPDase and 5'-nucleotidase activities, van Haaster, MM, Ostuni, MA, Sevigny, J, Pelletier, J, Hattab, C, Balcarcel, NB, Egido, P, Gonzalez, DA, Purinergic signalling, 2015, 10.1007/s11302-014-9437-0
- RPE cells express both NTPDasel and NTPDase2: resulting ADP can increase cell calcium, Mitchell, C. H., Stone, R. A., Laties, A. M., Sevigny, J., McGlinn, A., Pendrak, K., Reigada, D., Lu, W., 2004
- Synthesis and Biological Evaluation of Arylamide Sulphonate Derivatives as Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 and -3 Inhibitors, Iqbal, J, Sévigny, J, Pelletier, J, Ullah, S, ACS omega, 2022, 10.1021/acsomega.2c03473
- Synthesis and biological evaluation of sulfamate derivatives as inhibitors of carbonic anhydrases II and IX, Mohammed El-Gamal, Jamshed Iqbal, Taleb H. Al-Tel, Jean Sévigny, Julie Pelletier, Bilal O. AlKubaisi, Afnan I. Shahin, Rawan M. Sbenati, Seyed-Omar Zaraei, Saif Ullah, Saquib Jalil, Medicinal Chemistry Research, 2023, 10.1007/s00044-023-03043-9
- Generation and characterization of a monoclonal antibody as the first specific inhibitor of human NTPDase3, Sevigny, J., Kirley, T. L., Kuenzli, B., Tremblay, A., Pelletier, J., Ivanenkov, V. V., Fausther, M., Munkonda, M. N., 2010
- NTPDase7, Sévigny, J, UCSD-Nature Molecule Pages, 2006, 10.1038/mp.a003166.01
- Prevention and reversal of thrombotic and inflammatory processes, Leclerc, MC, St George, M, Gendron, FP, Sévigny, J, Beaudoin, AR, Emerging therapeutic targets, 1998, 10.1517/14728222.2.1.61
- Nucleoside triphosphate diphosphohydrolase (NTPDASE 8) and uses thereof, Jean Sévigny, 2005
- Synthesis of new class of indole acetic acid sulfonate derivatives as ectonucleotidases inhibitors, Jamshed Iqbal, Jean Sévigny, Julie Pelletier, Muhammad Siraj Khan Jadoon, RSC Advances, 2023, 10.1039/D3RA04266A
- Mutagenesis of vascular ATP diphosphohydrolase, Robson, S. C., Bach, F. H., Beaudoin, A. R., Imai, M., Sevigny, J., Koziak, K., Siegel, J. B., Kaczmarek, E., Esch, J. S. A., 1997
- A Simple and Efficient Genetic Immunization Protocol for the Production of Highly Specific Polyclonal and Monoclonal Antibodies against the Native Form of Mammalian Proteins, Sevigny, J, Babou Kammoe, RB, Luyindula, P, Salem, M, G Lavoie, E, Manica, F, Agonsanou, H, Pelletier, J, International journal of molecular sciences, 2020, 10.3390/ijms21197074
- 2-Substituted 7-trifluoromethyl-thiadiazolopyrimidones as alkaline phosphatase inhibitors. Synthesis, structure activity relationship and molecular docking study, Langer, P, Iqbal, J, Sevigny, J, Lecka, J, Ehlers, P, Kalugin, SN, Turmukhanova, MZ, Abilov, ZA, Safarov, S, Amjad, ST, Khan, SU, Yelibayeva, N, Ejaz, SA, Ospanov, M, Jafari, B, European journal of medicinal chemistry, 2018, 10.1016/j.ejmech.2017.11.068
- NTPDASE1 modulates P2X7 responses in murine peritoneal macrophages, Sevigny, Jean, Kukulski, Filip, Levesque, Sebastien A., 2008
- Generation and characterization of polyclonal and monoclonal antibodies to human NTPDase2 including a blocking antibody, Sevigny, J, Gulbransen, B, Salem, M, Fausther, M, Delvalle, N, Agonsanou, H, Pelletier, J, Purinergic signalling, 2017, 10.1007/s11302-017-9561-8
- Modulation of extracellular nucleotide-mediated signaling by CD39/nucleoside triphosphate diphosphohydrolase-1, Warny, M, Sévigny, J, Lin, Y, Kaczmarek, E, Imai, M, Goepfert, C, Enjyoji, K, Robson, SC, Drug development research, 2001, 10.1002/ddr.1188
- Ca2+ responses in enteric glia are mediated by connexin-43 hemichannels and modulate colonic transit in mice, Gulbransen, BD, Parpura, V, Sevigny, J, Leinninger, GM, Gomez-Suarez, RA, Fried, D, Grubisic, V, McClain, J, Gastroenterology, 2014, 10.1053/j.gastro.2013.10.061
- NTPDase1 (CD39) controls nucleotide-dependent vasoconstriction in mouse, Sevigny, J, Thorin, E, Marceau, F, D'Orleans-Juste, P, Robaye, B, Bachelard, H, Thorin-Trescases, N, Drouin, A, Kauffenstein, G, Cardiovascular research, 2010, 10.1093/cvr/cvp265
- Purification, characterization, and localization of two ATP diphosphohydrolase isoforms in bovine heart, Levesque, FP, Daoud, S, Grondin, G, Sévigny, J, Beaudoin, AR, The American journal of physiology, 1997, 10.1152/ajpheart.1997.273.2.H673
- Extracellular nucleotides mediate LPS-induced neutrophil migration in vitro and in vivo, Sevigny, J, Warny, M, Tessier, PA, Lefebvre, J, Ben Yebdri, F, Kukulski, F, Journal of leukocyte biology, 2007, 10.1189/jlb.1206758
- BORANOPHOSPHATE DERIVATIVES FOR THE TREATMENT OF OSTEOARTHRITIS, Lecka, Joanna, Eliahu, Shay, Fischer, Bilha, Jean Sévigny, 2012
- CD39/vascular ATP diphosphohydrolase modulates xenograft survival, Robson, SC, Rosenberg, RD, Bach, FH, Enjyoji, K, Goepfert, C, Kaczmarek, E, Sevigny, J, Lin, Y, Guckelberger, O, Takigami, K, Imai, M, Transplantation proceedings, 2000, 10.1016/s0041-1345(00)01065-4
- Palmitoylation targets CD39/endothelial ATP diphosphohydrolase to caveolae, Robson, SC, Qawi, I, Goepfert, C, Guckelberger, O, Imai, M, Schulte am Esch, J, Blusztajn, JK, Sévigny, J, Kittel, A, Kaczmarek, E, Koziak, K, The Journal of biological chemistry, 2000, 10.1074/jbc.275.3.2057
- Extracellular nucleotides in smooth muscle contraction, Jean Sévigny, Romuald Brice Babou Kammoe, Biochemical Pharmacology, 2024, 10.1016/j.bcp.2023.116005
- Synthesis, biological evaluation, and docking studies of new raloxifene sulfonate or sulfamate derivatives as inhibitors of nucleotide pyrophosphatase/phosphodiesterase, Iqbal, J, Sevigny, J, Pelletier, J, Anbar, HS, Omar, HA, Zaher, DM, Zaib, S, Jalil, S, Zaraei, SO, Ullah, S, El-Gamal, MI, European journal of medicinal chemistry, 2019, 10.1016/j.ejmech.2019.07.063
- Portal fibroblasts regulate the proliferation of bile duct epithelia via expression of NTPDase2, Dranoff, JA, Sevigny, J, Lavoie, EG, Kruglov, EA, ier, MN, Jh, The Journal of biological chemistry, 2005, 10.1074/jbc.M412371200
- ATP-diphosphohydrolases, Beaudoin Adrien, R., Jean Sévigny, 1998
- Physical exercise prevents alterations in purinergic system and oxidative status in lipopolysaccharide-induced sepsis in rats, Cardoso, AM, Schetinger, MRC, Morsch, VM, Sevigny, J, da Cruz, IBM, Lopes, TF, da Silva, AD, Reichert, KP, Pelinson, LP, da Costa, P, Stefanello, N, Assmann, CE, Bottari, NB, Miron, VV, Journal of cellular biochemistry, 2019, 10.1002/jcb.27590
- CD39/ecto-nucleoside triphosphate diphosphohydrolase-1 maintains vascular integrity in intestinal ischemia-reperfusion injury., Robson, S. C., Enjyoji, K., Kaczmarek, E., Imai, M., Sevigny, J., Sun, X. F., Guckelberger, O., 2004
- Purification and immunohistochemical localization of the ATP diphosphohydrolase in bovine lungs, Beaudoin, AR, Grondin, G, Picher, M, Sévigny, J, The American journal of physiology, 1997, 10.1152/ajplung.1997.272.5.L939
- Nucleotide signaling in adult neurogenesis, Robson, S. C., Sevigny, J., Kettenmann, H., Korf, H. W., Schomerus, C., Delic, J., Grimm, Y., Gampe, K., Braun, N., Shukla, V., Mishra, S. K., Langer, D., Zimmermann, H., 2007
- Establishment and characterization of rat portal myofibroblast cell lines, Dranoff, JA, Sevigny, J, Graham, AL, Lavoie, EG, Goree, JR, Fausther, M, PloS one, 2015, 10.1371/journal.pone.0121161
- Localization and role of ecto-5'-nucleotidase (CD73) in the basal ganglia - Relation to adenosine A2A receptors, Chen, J. F., Cunha, R. A., Sevigny, J., Matos, M., Augusto, E., 2012
- Silencing NTPDase3 activity rehabilitates the osteogenic commitment of post-menopausal stem cell bone progenitors, Paulo Correia-de-Sá, Jean Sévigny, Julie Pelletier, António Oliveira, Adélio Vilaça, Rui Lemos, Rolando Freitas, José Marinhas, Maria Adelina Costa, Fátima Ferreirinha, Maria Teresa Magalhães-Cardoso, Catarina Bessa-Andrês, Rui Pinto-Cardoso, José Bernardo Noronha-Matos, Stem Cell Research & Therapy, 2023, 10.1186/s13287-023-03315-6
- Feed-forward inhibition of CD73 and upregulation of adenosine deaminase contribute to the loss of adenosine neuromodulation in postinflammatory ileitis, Correia-de-Sa, P, Sevigny, J, Pelletier, J, Dias, AS, Silva, I, Ferreirinha, F, Magalhaes-Cardoso, MT, Vieira, C, Mediators of inflammation, 2014, 10.1155/2014/254640
- Extracellular ATP Selectively Upregulates Ecto-Nucleoside Triphosphate Diphosphohydrolase 2 and Ecto-5'-Nucleotidase by Rat Cortical Astrocytes In Vitro, Nedeljkovic, N, Kipp, M, Sevigny, J, Bjelobaba, I, Lavrnja, I, Milosevic, M, Parabucki, A, Laketa, D, Adzic, M, Brisevac, D, Journal of molecular neuroscience : MN, 2015, 10.1007/s12031-015-0601-y
- P2Y(6)-induced release of ATP from the urothelium exerts a dual role in the human urinary bladder, Correia-de-Sa, P., Sevigny, J., Silva-Ramos, M., Ferreirinha, F., Correia, J., Silva, I., 2013
- P2Y2 receptor transcription is increased by NF-kappa B and stimulates cyclooxygenase-2 expression and PGE2 released by intestinal epithelial cells, Gendron, FP, Sevigny, J, Weisman, GA, Jain, N, Langlois, C, Lavoie, EG, Dupuis, AA, Grbic, DM, Degagne, E, Journal of immunology (Baltimore, Md : 1950), 2009, 10.4049/jimmunol.0803977
- METHOD OF REDUCING ANGIOGENESIS, Hoshi, Tomokazu, Sundberg, Christian, Robson Simon, C., Jean Sévigny, 2003
- Comparative hydrolysis of P2 receptor agonists by NTPDases 1, 2, 3 and 8, Sevigny, J, Kirley, TL, Robson, SC, Knowles, AF, Bigonnesse, F, Lecka, J, Lavoie, EG, Levesque, SA, Kukulski, F, Purinergic signalling, 2005, 10.1007/s11302-005-6217-x
- Ghrelin is produced in taste cells and ghrelin receptor null mice show reduced taste responsivity to salty (NaCl) and sour (citric acid) tastants, Egan, JM, Maudsley, S, Tschop, MH, Sevigny, J, Smith, RG, Sun, Y, Ji, S, White, CM, Kim, W, Martin, B, Shin, YK, PloS one, 2010, 10.1371/journal.pone.0012729
- Impaired hepatic regeneration in liver-specific insulin receptor knockout, Sevigny, Jean, 2000
- The ectonucleotidase NTPDase1 controls IL-8 production by human neutrophils, Sevigny, Jean, Levesque, Sebstien, Martin-Satue, Mireia, Lecka, Joanna, Ben Yebdri, Fethia, Bahrami, Fariborz, Kukulski, Filip, 2010
- Identification of sulfonic acids as efficient ecto-5'-nucleotidase inhibitors, Bajorath, J, Sevigny, J, Lecka, J, Furtmann, N, Hameed, A, Matin, A, Raza, R, Saeed, A, Iqbal, J, European journal of medicinal chemistry, 2013, 10.1016/j.ejmech.2013.10.053
- Preclinical evaluation of bozepinib in bladder cancer cell lines: modulation of the NPP1 enzyme., Battastini AMO, Figueiró F, Sévigny J, Campos JM, Conejo-García A, Cruz-López O, Morrone FB, Weber AF, de Fraga Dias A, Scholl JN, da Silva ÁC, Purinergic signalling, 2023, 10.1007/s11302-023-09975-6
- Imatinib mesylate affects extracellular ATP catabolism and expression of NTPDases in a chronic myeloid leukemia cell line, Pilger, DA, Buffon, A, Wink, MR, Sevigny, J, Beckenkamp, LR, Beckenkamp, A, Vianna, DRB, Willig, JB, Purinergic signalling, 2020, 10.1007/s11302-019-09686-x
- E-NTPDase family, Sévigny, J, Book E-NTPDase family, 2018, 10.1007/978-1-4614-6438-9_197-1
- Quinazoline-4-piperidine sulfamides are specific inhibitors of human NPP1 and prevent pathological mineralization of valve interstitial cells, Mathieu, P, Paquin, JF, Sevigny, J, Lague, P, Barbeau, X, Dautrey, S, Mahmut, A, Boulanger, MC, Forcellini, E, Shayhidin, EE, British journal of pharmacology, 2015, 10.1111/bph.13204
- Correction to: Identification of adenine-N9-(methoxy)ethyl-β-bisphosphonate as NPP1 inhibitor attenuates NPPase activity in human osteoarthritic chondrocytes, Fischer, B, Muller, CE, Sevigny, J, Pelletier, J, Zimmermann, H, Renn, SMC, Journo, S, Lee, SY, Arad, U, Nassir, M, Purinergic signalling, 2019, 10.1007/s11302-019-09671-4
- Synthesis and structure-activity relationship of uracil nucleotide derivatives towards the identification of human P2Y6 receptor antagonists, Fischer, B, Gendron, FP, Sevigny, J, Lecka, J, Danino, O, Nadel, Y, Arguin, G, Ethan, O, Meltzer, D, Bioorganic & medicinal chemistry, 2015, 10.1016/j.bmc.2015.07.004
- Palladium-catalyzed synthesis and nucleotide pyrophosphatase inhibition of benzo[4,5]furo[3,2-]indoles, Langer, P, Iqbal, J, Ehlers, P, Sevigny, J, Lecka, J, Villinger, A, Ullah, S, Do, HH, Beilstein journal of organic chemistry, 2019, 10.3762/bjoc.15.276
- Extracellular ATP and P2 receptors are required for IL-8 to induce neutrophil migration, Sevigny, J, Martin-Satue, M, Levesque, SA, Kauffenstein, G, Lecka, J, Ben Yebdri, F, Kukulski, F, Cytokine, 2009, 10.1016/j.cyto.2009.02.011
- Synthesis, Characterization, and In Silico Studies of Novel Spirooxindole Derivatives as Ecto-5'-Nucleotidase Inhibitors, Iqbal, J, Yaqub, M, Sevigny, J, Pelletier, J, Tahir, MN, Khan Jadoon, MS, Shafiq, Z, Ashraf, A, ACS medicinal chemistry letters, 2020, 10.1021/acsmedchemlett.0c00343
- Diacylhydrazine Derivatives of 2-(5-(Pyridin-3-yl)-2H-Tetrazol-2-yl)Acetohydrazide and 2-(5-(Pyridin-4-yl)-2H-Tetrazol-2-yl)Acetohydrazide as Potential Inhibitors of Nucleotide Pyrophosphatase, J. Iqbal, J. Sévigny, J. Lecka, S. U. Khan, A. Saeed, S. A. Ejaz, G. Shabir, M. Arif, Russian Journal of Bioorganic Chemistry, 2022, 10.1134/s1068162022050053
- Synthesis of new sulphonate derivatives containing adamantane and 4-chlorophenyl moieties as nucleotide pyrophosphatase/phosphodiesterase-1 and -3 inhibitors, Jamshed Iqbal, Peter Langer, Abdul Rehman Khan, Jean Sévigny, Julie Pelletier, Amna Batool, Kiran Hamid, Saif Ullah, Journal of Molecular Structure, 2023, 10.1016/j.molstruc.2022.134494
- Extracellular nucleotides and ectonucleotidases control IL-8 production in human colon HT-29 cells, Sevigny, Jean, Pelletier, Julie, Lecka, Joanna, Kukulski, Filp, Bahrami, Fariborz, 2010
- The P2 receptor antagonist PPADS abrogates LPS-induced neutrophil migration in the murine air pouch via inhibition of MIP-2 and KC production, Sevigny, J, Martin-Satue, M, Levesque, SA, Bahrami, F, Ben Yebdri, F, Kukulski, F, Molecular immunology, 2010, 10.1016/j.molimm.2009.09.037
- Development of Anthraquinone Derivatives as Ectonucleoside Triphosphate Diphosphohydrolase (NTPDase) Inhibitors With Selectivity for NTPDase2 and NTPDase3, Muller, CE, Fiene, A, Sevigny, J, Pelletier, J, Malik, EM, Schakel, L, Rashed, M, Baqi, Y, Frontiers in pharmacology, 2020, 10.3389/fphar.2020.01282
- Beneficial effects of CD39/ecto-nucleoside triphosphate diphosphohydrolase-1 in murine intestinal ischemia-reperfusion injury, Robson, SC, Kruskal, JB, Enjyoji, K, Kaczmarek, E, Imai, M, Sévigny, J, Sun, XF, Guckelberger, O, Thrombosis and haemostasis, 2004, 10.1160/TH03-06-0373
- Canalicular ecto-ATPase is a novel member of the GDA 1/CD39 NTPase family, Robson, SC, Smith, NR, Csizmadia, E, Lemmens, R, Sevigny, J, Hepatology, 1999
- Cloning and characterization of mouse nucleoside triphosphate diphosphohydrolase-8, Sévigny, J, es, MJ, Fern, Robson, SC, Lecka, J, Kukulski, F, Lévesque, SA, Bigonnesse, F, Biochemistry, 2004, 10.1021/bi0362222
- Characterization and antiproliferative activity of glioma-derived extracellular vesicles, Battastini, AMO, Figueiro, F, Guterres, SS, Pohlmann, AR, Sevigny, J, Rohden, F, Colombo, M, Souto, GD, rey, EHF, J, Moritz, CEJ, Lopes, DV, Pizzato, PR, de Fraga Dias, A, Scholl, JN, Nanomedicine (London, England), 2020, 10.2217/nnm-2019-0431
- Opposite deregulations of NTPDase1 (CD39) and NTPDase3 by cystic fibrosis, Sevigny, Jean, Ribeiro, Carla M., Pelletier, Julie, Fausther, Michel, Picher, Maryse, 2010
- Synthesis and structure–activity relationships of ticlopidine derivatives and analogs as inhibitors of ectonucleotidase CD39, Christa E. Müller, Jean Sévigny, Thanigaimalai Pillaiyar, Sang-Yong Lee, Julie Pelletier, Katharina Sylvester, Salahuddin Mirza, Laura Schäkel, Chunyang Bi, Bioorganic Chemistry, 2023, 10.1016/j.bioorg.2023.106460
- Concentrates of two subsets of extracellular vesicles from cow's milk modulate symptoms and inflammation in experimental colitis, Provost, P, Sevigny, J, Gilbert, C, Michel, S, Salem, M, Diallo, I, Benmoussa, A, Scientific reports, 2019, 10.1038/s41598-019-51092-1
- Stimulation of the P2Y1 receptor up-regulates nucleoside-triphosphate diphosphohydrolase-1 in human retinal pigment epithelial cells, Mitchell, CH, Sevigny, J, Reigada, D, Lu, W, The Journal of pharmacology and experimental therapeutics, 2007, 10.1124/jpet.107.124545
- Regulation of insulin secretion by NTPDase3, Sevigny, Jean, Fausther, Michel, Lavoie, Elise G., 2008
- Ecto-5'-nucleotidase/CD73 contributes to the radiosensitivity of T24 human bladder cancer cell line, Battastini, AMO, Morrone, FB, Sevigny, J, Filho, AB, Roesler, R, de Paula, PB, Tremblay, A, Rockenbach, L, Cappellari, AR, Filippi-Chiela, EC, Figueiro, F, Dietrich, F, Journal of cancer research and clinical oncology, 2018, 10.1007/s00432-017-2567-3
- Hybrid compounds from chalcone and 1,2-benzothiazine pharmacophores as selective inhibitors of alkaline phosphatase isozymes, Hanif, M, Hartinger, CG, Iqbal, J, Asiri, AM, Zayed, MEM, Sevigny, J, Lecka, J, Arshad, MN, Siddiqui, WA, Rahman, SU, Ashraf, A, Ejaz, SA, European journal of medicinal chemistry, 2018, 10.1016/j.ejmech.2018.09.063
- Adenosine A receptor and ecto-5'-nucleotidase/CD73 are upregulated in hippocampal astrocytes of human patients with mesial temporal lobe epilepsy (MTLE), Correia-de-Sa, P, Cordeiro, JM, Sevigny, J, Pelletier, J, Rangel, R, Santos, A, Lobo, MG, Mendes, M, Oliveira, A, Ferreirinha, F, Barros-Barbosa, AR, Purinergic signalling, 2016, 10.1007/s11302-016-9535-2
- Identification of the ectonucleotidases expressed in mouse, rat, and human Langerhans islets: potential role of NTPDase3 in insulin secretion, Sevigny, J, Friess, H, Kunzli, BM, Kukulski, F, Kauffenstein, G, Fausther, M, Lavoie, EG, American journal of physiology Endocrinology and metabolism, 2010, 10.1152/ajpendo.00126.2010
- Distribution of different ATP-diphosphohydrolase isoforms in mammalian organs, Sevigny, J., Grondin, G., Beaudoin, A. R., Ecto-ATPases : recent progress on structure and function : [proceedings of the First International workshop on ecto-ATPases, held August 26-30, 1996, in Mar de Plata, Argentina], 1997, 10.1007/978-1-4615-5955-9_5
- Bioscaffold developed with decellularized human amniotic membrane seeded with mesenchymal stromal cells: assessment of efficacy and safety profiles in a second-degree burn preclinical model, Marcia Wink, Jean Sévigny, Marilda Da Cruz Fernandes, Pablo Fagundes Pase, Aline Francielle Damo Souza, Thaís Casagrande Paim, Carla Zanatelli, Luiza Pretto, Liliana Ivet Sous Naasani, Biofabrication, 2023, 10.1088/1758-5090/ac9ff4
- Characterization of ecto-nucleotidases in human oviducts with an improved approach simultaneously identifying protein expression and in situ enzyme activity, Martin-Satue, M, Matias-Guiu, X, Sevigny, J, a, I, Gomez de Ar, Vidal, A, Trapero, C, Rodriguez-Martinez, A, Torrejon-Escribano, B, Villamonte, ML, Histochemistry and cell biology, 2018, 10.1007/s00418-017-1627-8
- Ectonucleotidase NTPDase2 is selectively down-regulated in biliary cirrhosis, Sévigny, J, Knowles, AF, Jain, D, Zimmermann, H, Braun, N, Toure, J, Kruglov, EA, Dranoff, JA, Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 2004, 10.1136/jim-52-07-42
- Adenine-(methoxy)-ethoxy-P-dithio-triphosphate inhibits pathologic calcium pyrophosphate deposition in osteoarthritic human chondrocytes, Fischer, B, Muller, CE, Sevigny, J, Pelletier, J, Zimmermann, H, Renn, C, Yaw Attah, I, Rafehi, M, Lee, S, Arad, U, Mirza, S, Nassir, M, Organic & biomolecular chemistry, 2019, 10.1039/c9ob02199j
- Immunolocalization of ectonucleotidases along the rat nephron, Unwin, RJ, Sévigny, J, Shirley, DG, Vekaria, RM, American journal of physiology Renal physiology, 2006, 10.1152/ajprenal.00151.2005
- Heparins are potent inhibitors of ectonucleotide pyrophosphatase/phospho-diesterase-1 (NPP1) – a promising target for the immunotherapy of cancer, Christa E. Müller, Gerd Bendas, Sang-Yong Lee, Björn Scheffler, Annamaria Naggi, Jean Sévigny, Julie Pelletier, Christian Renn, Laura Schäkel, Riham M. Idris, Katharina Sylvester, Michael S. Schmidt, Victoria J. Vaaßen, Salahuddin Mirza, H. J. Maximilian Schuh, Vittoria Lopez, Frontiers in Immunology, 2023, 10.3389/fimmu.2023.1173634
- Synthesis of biphenyl oxazole derivatives via Suzuki coupling and biological evaluations as nucleotide pyrophosphatase/phosphodiesterase-1 and -3 inhibitors, Iqbal, J, Hassan, A, Sevigny, J, Pelletier, J, Saeed, A, Rahman, F, Ullah, S, Ahmad, H, European journal of medicinal chemistry, 2020, 10.1016/j.ejmech.2020.112759
- Identification of hydrolytically stable and selective P2Y(1) receptor agonists, Fischer, Bilha, Gelinas, Sylvie, Sevigny, Jean, Weisman, Gary A., Lecka, Joanna, Camden, Jean, Elyahu, Shay, Purinergic Signalling, 2008, 10.1016/J.EJMECH.2008.07.015
- 2-MeS-beta,gamma-CCl2-ATP is a potent agent for reducing intraocular pressure, Fischer, B, Sevigny, J, Lecka, J, Weisman, GA, Camden, J, Pintor, J, Perez de Lara, MJ, Martin-Gil, A, Eliahu, S, Journal of medicinal chemistry, 2010, 10.1021/jm100030u
- Mammalian ATP-diphosphohydrolases and process of purification thereof, Robson, Simon, Bach Fitz, H., Beaudoin Adrien, R., Jean Sévigny, 2001
- Synthesis and Nucleotide Pyrophosphatase/Phosphodiesterase Inhibition Studies of Carbohydrazides Based on Benzimidazole-Benzothiazine Skeleton, Iqbal, J, Iqbal, M, Sevigny, J, Sultan, S, Aslam, S, Pelletier, J, Ahmad, M, Ullah, S, Kanwal, A, ChemistrySelect, 2020, 10.1002/slct.202003479
- The C-terminal cysteine-rich region dictates specific catalytic properties in chimeras of the ectonucleotidases NTPDase1 and NTPDase2, Zimmermann, H, Servos, J, Robson, SC, Sévigny, J, Braun, N, Heine, P, European journal of biochemistry, 2001, 10.1046/j.1432-1033.2001.01896.x
- Purification of the blood vessel ATP diphosphohydrolase, identification and localisation by immunological techniques, Beaudoin, AR, Grondin, G, Levesque, FP, Sévigny, J, Biochimica et biophysica acta, 1997, 10.1016/s0304-4165(96)00079-7
- Nucleotide signaling in quiescent and activated hepatic stellate cells., Wells, Rebecca G., Gaca, Mariana D. A., Sevigny, Jean, Kruglov, Emma A., Dranoff, Jonathan Ankin, 2003
- From the Cover: CD39 deletion exacerbates experimental murine colitis and human polymorphisms increase susceptibility to inflammatory bowel disease, Robson, SC, Friess, H, Csizmadia, E, Enjyoji, K, Berberat, PO, Sevigny, J, A-Rahim, YI, Kunzli, BM, Friedman, DJ, Proceedings of the National Academy of Sciences of the United States of America, 2009, 10.1073/pnas.0902869106
- The ecto-nucleotidase NTPDase2 is selectively down-regulated in biliary fibrosis., Sévigny, Jean, 2003
- Synthesis, characterization and biological evaluation of N-(2,3-dimethyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-4-yl)benzamides, Iqbal, J, Sevigny, J, Lecka, J, Latif, M, al-Rashida, M, Hassan, S, Khurshid, A, Ejaz, SA, Saeed, A, RSC advances, 2015
- Homeostasis of extracellular ATP in uninfected RBCs from a Plasmodium falciparum culture and derived microparticles, Schwarzbaum, PJ, Ostuni, MA, Lauri, N, Denis, MFL, Sévigny, J, Hattab, C, Fader, CM, Lapouméroulie, C, Gamain, B, Semblat, JP, Chêne, A, Alvarez, CL, Biochimica et biophysica acta Biomembranes, 2022, 10.1016/j.bbamem.2022.183980
- Ecto-nucleotidases: Multiplicity and role in the nervous system, Robson, S. C., Sevigny, J., Failer, B. U., Vollmayer, P., Braun, N., Zimmermann, H. I., 2002
- Chemoselective synthesis and biological evaluation of arylated 2-(Trifluoromethyl) quinolines as nucleotide pyrophosphatase (NPPs) inhibitors, Langer, P, Iqbal, J, Spannenberg, A, Ehlers, P, Sevigny, J, Lecka, J, Khan, SU, Afzal, S, Ejaz, SA, Kuhrt, D, European journal of medicinal chemistry, 2017, 10.1016/j.ejmech.2017.07.017
- Characterization of a monoclonal antibody as the first specific inhibitor of human NTP diphosphohydrolase-3, Sevigny, Jean, Kirley, Terence L., Kuenzli, Beat, Tremblay, Alain, Fausther, Michel, Ivanenkov, Vasily V., Pelletier, Julie, Munkonda, Mercedes N., The FEBS Journal, 2009, 10.1111/J.1742-4658.2008.06797.X
- CD39 delineates chimeric antigen receptor regulatory T cell subsets with distinct cytotoxic & regulatory functions against human islets, Everett H. Meyer, Kent P. Jensen, Seung K. Kim, Alvin C. Powers, Anna L. Gloyn, Seth A. Sharp, Marina Basina, David M. Maahs, Jean Sévigny, Erick Spears, Allison Hestor, Diane C. Saunders, Bettina P. Iliopoulou, Shiva Pathak, William Harper, Yong Bin Kim, Hao Yan, Vy M. N. Coykendall, Matthew S. MacDougall, Robert L. Whitener, Pin-I Chen, Xiangni Wu, Frontiers in Immunology, 2024, 10.3389/fimmu.2024.1415102
- Identification of thienopyrimidine glycinates as selective inhibitors for h-NTPDases, Abbas Hassan, Jamshed Iqbal, Jean Sévigny, Julie Pelletier, Ahsanullah, Farman Ullah, Muhammad Uzair, Muhammad Akram, Saif Ullah, Zahra Begum, Bioorganic Chemistry, 2022, 10.1016/j.bioorg.2022.106196
- Blue blocker glasses impede the capacity of bright light to suppress melatonin production, Hébert, M, Sévigny, J, Paquet, N, Sasseville, A, Journal of pineal research, 2006, 10.1111/j.1600-079X.2006.00332.x
- Le monde des nucléotides extracellulaires, Beaudoin, AR, Sévigny, J, Medecine sciences : M/S, 1994
- NTPDase1 and -2 are expressed by distinct cellular compartments in the mouse colon and differentially impact colonic physiology and function after DSS colitis, Gulbransen, BD, Galligan, JJ, Robson, SC, Sevigny, J, Fried, DE, Perez-Medina, AL, Grubisic, V, American journal of physiology Gastrointestinal and liver physiology, 2019, 10.1152/ajpgi.00104.2019
- NTPDase3 and ecto-5'-nucleotidase/CD73 are differentially expressed during mouse bladder cancer progression, Battastini, AM, Sevigny, J, Morrone, FB, Edelweiss, MI, Pugliese, M, Figueiro, F, Dietrich, F, Braganhol, E, Rockenbach, L, Purinergic signalling, 2014, 10.1007/s11302-014-9405-8
- Thienopyridines as specific inhibitors of NTPDase1, Sevigny, Jean, Fausther, Michel, Lecka, Joanna, 2008
- Protein kinase inhibitor ceritinib blocks ectonucleotidase CD39 - a promising target for cancer immunotherapy, Müller, CE, Tolosa, E, Sévigny, J, Pelletier, J, Al-Hroub, H, Idris, R, Lopez, V, Winzer, R, Mirza, S, Schäkel, L, Journal for immunotherapy of cancer, 2022, 10.1136/jitc-2022-004660
- Synthesis, biological evaluation, and docking studies of new pyrazole-based thiourea and sulfonamide derivatives as inhibitors of nucleotide pyrophosphatase/phosphodiesterase, Iqbal, J, Oh, CH, Sevigny, J, Pelletier, J, Sbenati, RM, Zaraei, SO, Anbar, HS, Zaib, S, El-Gamal, MI, Ullah, S, Bioorganic chemistry, 2020, 10.1016/j.bioorg.2020.103783
- Nucleoside triphosphate diphosphohydrolase-2 is the ecto-ATPase of type I cells in taste buds, Finger, Thomas E., Sevigny, Jean, Lavoie, Elise G., Sullivan, Susan L., Bartel, Dianna L., Journal of Comparative Neurology, 2006, 10.1002/CNE.20954
- Synthesis, biological evaluation, and molecular docking study of sulfonate derivatives as nucleotide pyrophosphatase/phosphodiesterase (NPP) inhibitors, Iqbal, J, Sevigny, J, Lecka, J, Anbar, HS, Zaib, S, Jalil, S, Ullah, S, El-Gamal, MI, Semreen, MH, Bioorganic & medicinal chemistry, 2019, 10.1016/j.bmc.2019.04.031
- Intestinal inflammation up-regulates the expression of the G protein-coupled receptor P2Y2 at the transcriptional level, -Pierre, Gendron, Fern, Sevigny, Jean, Dupuis, Andree-Anne, Lavoie, Elyse, Grbic, Djordje, Degagne, Emilie, 2008
- Demonstration and immunolocalization of ATP diphosphohydrolase in the pig digestive system, Beaudoin, AR, Roy, J, Gendron, FP, Grondin, G, Sévigny, J, The American journal of physiology, 1998, 10.1152/ajpgi.1998.275.3.G473
- NTPDase2 is necessary for regulation of bile duct epithelial proliferation by portal fibroblasts, Sevigny, J, Kruglov, EA, Jhandier, MN, Dranoff, JA, The FASEB Journal, 2004
- Influence of NSAIDs and methotrexate on CD73 expression and glioma cell growth, Figueiró, F, Battastini, AMO, Sévigny, J, Scholl, JN, Silva, LFL, de Fraga Dias, A, Lopes, DV, Purinergic signalling, 2021, 10.1007/s11302-021-09775-w
- Identification of adenine-N9-(methoxy)ethyl-β-bisphosphonate as NPP1 inhibitor attenuates NPPase activity in human osteoarthritic chondrocytes, Fischer, B, Muller, CE, Sevigny, J, Pelletier, J, Zimmermann, H, Renn, C, Mirza, S, Journo, S, Lee, SY, Arad, U, Nassir, M, Purinergic signalling, 2019, 10.1007/s11302-019-09649-2
- Carbon monoxide can fully substitute heme oxygenase-1 in suppressing the rejection of mouse to rat cardiac transplants, Soares, Miguel P., Bach, Fritz H., Choi, Augustine M., Vercellotti, Gregory, Robson, Simon C., Sevigny, Jean, Anrather, Josef, Csizmadia, Eva, Lin, Yuan, Brouard, Sophie, Smith, Neal, Otterbein, Leo, Balla, Jozsef, Sato, Koichiro, 2000
- New insights into cytotoxic mechanisms of bozepinib against glioblastoma, Fabrício Figueiró, Ana Maria Oliveira Battastini, Joaquin María Campos, Jean Sévigny, Ana Conejo-García, Olga Cruz-López, Vera Lúcia Eifler-Lima, Gustavo Machado das Neves, Luciano Porto Kagami, Cesar Eduardo Jacintho Moritz, Juliete Nathali Scholl, Amanda de Fraga Dias, European Journal of Pharmaceutical Sciences, 2021, 10.1016/j.ejps.2021.105823
- Cochlear distribution of NTPDase1 and 2, Housley, GD, Robson, SC, Sevigny, J, Thorne, PR, Vlaikovic, SM, Drug Development Research, 2002
- Disordered cellular migration and angiogenesis in cd39-null mice, Robson, S, Csizmadia, E, Hoshi, T, Enjyoji, K, Sévigny, J, Sundberg, C, Goepfert, C, Circulation, 2001, 10.1161/hc5001.100663
- Localization of CD39L1/vascular NTP diphosphohydrolase (NTPDase2) in murine kidney, Robson, S. C., Sevigny, J., Isaac, J., Kishore, B. K., 2002
- Leishmania infantum NTPDase1 and NTPDase2 play an important role in infection and nitric oxide production in macrophages, Juliana Lopes Rangel Fietto, Barbara Papadopoulou, Jean Sévigny, Julie Pelletier, Carole Dumas, Raphael de Souza Vasconcellos, Gustavo Costa Bressan, Tatiana Aparecida Oliveira, Luciana Ângelo de Souza, Victor Hugo Ferraz da Silva, Joice de Melo Agripino, Isadora Cunha Ribeiro, Walmir da Silva, Acta Tropica, 2023, 10.1016/j.actatropica.2022.106732
- Expression of the ecto-ATPase NTPDase2 in the germinal zones of the developing and adult rat brain, Zimmermann, H, Hammer, K, Gerstberger, R, Barth, SW, Robson, SC, Mishra, SK, Sevigny, J, Braun, N, The European journal of neuroscience, 2003, 10.1046/j.1460-9568.2003.02567.x
- HIGHLY SELECTIVE AND POTENT NPP1 INHIBITORS BASED ON URIDINE-5'-P,-DITHIOPHOSPHATE ANALOGUES, Muller, Christa, Arad Uri, Moshe, Zelikman, Vadim, Nassir, Molhm, Fischer Hana, Bilha, Jean Sévigny, 2022
- Synthesis, In-vitro evaluation and molecular docking studies of oxoindolin phenylhydrazine carboxamides as potent and selective inhibitors of ectonucleoside triphosphate diphosphohydrolase (NTPDase), Iqbal, J, Sévigny, J, Pelletier, J, Hameed, A, Al-Rashida, M, Afzal, S, Bioorganic chemistry, 2021, 10.1016/j.bioorg.2021.104957
- NTPDase moduliert die Thrombusbildung und Typ1-Endothelzellaktivierung im experimentellen Ischämie-Reperfusions-Schaden des Dünndarmes*, S. C. Robson, P. Neuhaus, E. Kaczmarek, M. Imai, K. Enjyoji, J. B. Kruskal, J. Sévigny, Olaf Guckelberger, Deutsche Gesellschaft für Chirurgie, 2000, 10.1007/978-3-642-57295-1_53
- ATP diphosphohydrolase (CD39) gene therapy for inflammatory or thrombotic conditions and transplantation and means there for, Beaudoin Adrien, R., Robson, Simon, Bach Fritz, H., Jean Sévigny, 2006
- Coexpression of ecto-5'-nucleotidase/CD73 with specific NTPDases differentially regulates adenosine formation in the rat liver, Sevigny, J, Dranoff, JA, Sheung, N, Pelletier, J, Kauffenstein, G, Soliman, E, Lecka, J, Fausther, M, American journal of physiology Gastrointestinal and liver physiology, 2012, 10.1152/ajpgi.00165.2011
- ATP-DIPHOSPHOHYDROLASES, PROCESS OF PURIFICATION THEREOF AND PROCESS OF PRODUCING THEREOF BY RECOMBINANT TECHNOLOGY, Beaudoin Adrien, R., Jean Sévigny, 1996
- Expression of Plasma Membrane Bound Ectonucleotidases in the Male Murine Reproductive Tract, Sevigny, Jean, Robson, Simon, Fausther, Michel, Lavoie, Elise, Martin Satue, Mireia, 2009
- Identification and characterization of membrane-associated hepatic NTP diphosphohydrolases., Robson, S. C., Kirley, T., Zimmermann, H., Smith, R. N., Csizmadia, E., Kruglov, E., Lemmens, R., Braun, N., Dranoff, J. A., Sevigny, J., 2001
- Atp-diphosphohydrolases, process of purification thereof and process of producing thereof by recombinant technology, Beaudoin Adrien, R., Jean Sévigny, 1996
- TREATMENT OF INFLAMMATORY BOWEL DISEASE WITH NUCLEOSIDE TRIPHOSPHATE DISPHOSHOHYDROLASE, P2Y2 ANTAGONIST AND/OR P2Y6 ANTAGONIST, Salem, Mabrouka, Jean Sévigny, 2018
- The nucleoside triphosphate diphosphohydrolase-1/CD39 is incorporated into human immunodeficiency type 1 particles, where it remains biologically active, Tremblay, MJ, Sevigny, J, Beaudoin, AR, Martin, G, Barat, C, Journal of molecular biology, 2007, 10.1016/j.jmb.2007.05.012
- Ectonucleotidases in the digestive system: focus on NTPDase3 localization, Sevigny, J, Sharkey, KA, Aliagas, E, Martin-Satue, M, Gulbransen, BD, Lavoie, EG, American journal of physiology Gastrointestinal and liver physiology, 2011, 10.1152/ajpgi.00207.2010
- NTPDase1/CD39 Ectonucleotidase Is Necessary for Normal Arterial Diameter Adaptation to Flow, Gilles Kauffenstein, Daniel Henrion, Jean Sévigny, Eric Thorin, Simon C. Robson, Marc-Antoine Gillis, Manon Laprise, Annick Drouin, Anne-Laure Guihot, Charlotte Roy, Julie Favre, International Journal of Molecular Sciences, 2023, 10.3390/ijms242015038
- Expression of Ecto-nucleoside Triphosphate Diphosphohydrolases-2 and -3 in the Enteric Nervous System Affects Inflammation in Experimental Colitis and Crohn's Disease, Jiang, ZG, Robson, SC, Sévigny, J, Müller, CE, Cheifetz, AS, Wu, Y, Stephan, H, hu, B, S, Longhi, MS, Mitsuhashi, S, Csizmadia, E, Yee, EU, Moss, AC, Feldbrügge, L, Journal of Crohn's & colitis, 2017, 10.1093/ecco-jcc/jjx058
- ATP-DIPHOSPHOHYDROLASES AND PROCESS OF PURIFICATION THEREOF, Beaudoin Adrien, R., Jean Sévigny, 1996
- Fluorescent N2,N3-epsilon-adenine nucleoside and nucleotide probes: synthesis, spectroscopic properties, and biochemical evaluation, Fischer, B, Reiser, G, Ecke, D, Sévigny, J, Munkonda, MN, Lévesque, SA, Sharon, E, Chembiochem : a European journal of chemical biology, 2006, 10.1002/cbic.200600070
- Inhibition of human and mouse plasma membrane bound NTPDases by P2 receptor antagonists, Sevigny, J, Lecka, J, Lavoie, EG, Pelletier, J, Legendre, C, Levesque, SA, Kukulski, F, Kauffenstein, G, Munkonda, MN, Biochemical pharmacology, 2007, 10.1016/j.bcp.2007.07.033
- Light, Adenosine Transporters, And Ecto-nucleotidases Contribute To Adenosine Levels In The Outer Retina, Sevigny, Jean, Dale, Nicholas, Stella, Salvatore L., Jr., 2011
- Synthesis, characterization, in vitro tissue-nonspecific alkaline phosphatase (TNAP) and intestinal alkaline phosphatase (IAP) inhibition studies and computational evaluation of novel thiazole derivatives, Iqbal, J, Sevigny, J, Pelletier, J, Shafiq, Z, Saeed, A, Zaib, S, Mahmood, A, Aziz, H, Bioorganic chemistry, 2020, 10.1016/j.bioorg.2020.104088
- Histamine induces ATP release from human subcutaneous fibroblasts, via pannexin-1 hemichannels, leading to Ca2+ mobilization and cell proliferation, Correia-de-Sa, P, Sevigny, J, Ferreirinha, F, Magalhaes-Cardoso, MT, Costa, C, Costa, MA, Certal, M, Paramos-de-Carvalho, D, Pinheiro, AR, The Journal of biological chemistry, 2013, 10.1074/jbc.M113.460865
- UTP increases wound healing in the self assembled skin substitute (SASS), Véronique J. Moulin, Marcia Wink, Jean Sévigny, Liliana I. Sous Naasani, Journal of Cell Communication and Signaling, 2023, 10.1007/s12079-023-00725-2
- 2-Hexylthio-β,γ-CH2-ATP is an effective and selective NTPDase2 inhibitor, Fischer, B, Sevigny, J, Senderowitz, H, Martin-Satue, M, Fausther, M, Munkonda, MN, Simhaev, L, Lecka, J, Gillerman, I, Journal of medicinal chemistry, 2014, 10.1021/jm401933c
- CD39 is the dominant Langerhans cell-associated ecto-NTPDase: modulatory roles in inflammation and immune responsiveness, Takashima, A, Enjyoji, K, Matsue, H, Sévigny, J, Robson, SC, Kumamoto, T, Mizumoto, N, Nature medicine, 2002, 10.1038/nm0402-358
- The endothelial P2Y2 receptor mediates LPS-induced neutrophil transendothelial migration, Sevigny, Jean, Tremblay, Alain, Fausther, Michel, Ben Yebdri, Fethia, Kukulski, Filip, Purinergic Signalling, 2008
- Disordered hemostasis and thromboregulation in cd39-deficient mice, Sévigny, Jean, 1999
- Structural investigation on thiazolo[5,4-d]pyrimidines to obtain dual-acting blockers of CD73 and adenosine A receptor as potential antitumor agents, Colotta, V, Varani, K, Sevigny, J, Guilbaud, A, ie, M, Sarl, Espindola Gelsleichter, N, Lopes Rangel Fietto, J, Pelletier, J, Pasquini, S, Vincenzi, F, Catarzi, D, Varano, F, Bioorganic & medicinal chemistry letters, 2020, 10.1016/j.bmcl.2020.127067
- ATP diphosphohydrolase (CD39) gene therapy for inflammatory or thrombotic conditions and transplantation and means therefor, BEAUDOIN ADRIEN R., ROBSON SIMON, BACH FRITZ H., Jean Sévigny, 2004
- Nucleotide Analog ARL67156 as a Lead Structure for the Development of CD39 and Dual CD39/CD73 Ectonucleotidase Inhibitors, Muller, CE, Namasivayam, V, Sevigny, J, Pelletier, J, Vu, TH, Mirza, S, Lopez, V, Lee, SY, Luo, X, Idris, RM, Schmies, CC, Schakel, L, Frontiers in pharmacology, 2020, 10.3389/fphar.2020.01294
- Purine-metabolizing ectoenzymes control IL-8 production in human colon HT-29 cells, Sevigny, J, Rockenbach, L, Pelletier, J, Tremblay, A, Lecka, J, Kukulski, F, Bahrami, F, Mediators of inflammation, 2014, 10.1155/2014/879895
- Cystic fibrosis remodels the regulation of purinergic signaling by NTPDase1 (CD39) and NTPDase3, Picher, M, Sevigny, J, Ribeiro, CM, Pelletier, J, Fausther, M, American journal of physiology Lung cellular and molecular physiology, 2010, 10.1152/ajplung.00019.2010
- Essential role of P2Y6 receptor in vascular contraction-lessons from P2Y6 knockout mice, Henrion, Daniel, Robaye, Bernard, Sevigny, Jean, Loufrani, Laurent, Kauffenstein, Gilles, 2010
- Vascular ATP diphosphohydrolase (CD39/ATPDase), Robson, S. C., Bach, F. H., Beaudoin, A., Hancock, W. W., Koziak, K., Sevigny, J., Siegel, J. B., Kaczmarek, E., Ecto-ATPases : recent progress on structure and function : [proceedings of the First International workshop on ecto-ATPases, held August 26-30, 1996, in Mar de Plata, Argentina], 1997, 10.1007/978-1-4615-5955-9_22
- Identification and characterization of a novel hepatic canalicular ATP diphosphohydrolase, Lemmens, R, Smith, RN, Csizmadia, E, Waelkens, E, Robson, SC, Sévigny, J, The Journal of biological chemistry, 2000, 10.1074/jbc.275.8.5640
- Effect of P2 receptor antagonists and potential inhibitors on plasma membrane NTPDases., Sevigny, J., Lecka, J., Legendre, C., Levesque, S. A., 2005
- Purinergic Signalling in Immune System Regulation in Health and Disease, Pintor, J, Martin-Satue, M, Sevigny, J, Mediators of inflammation, 2015, 10.1155/2015/106863
- Localization of CD39/vascular NTP diphosphohydrolase (NTPDase) in rat kidney., Robson, S. C., Sevigny, J., Tripp, S. R., Isaac, J., Kishore, B. K., 2002
- Identification of novel chromone based sulfonamides as highly potent and selective inhibitors of alkaline phosphatases, Iqbal, Jamshed, Papatriantafyllopoulou, Constantina, Muddassar, Muhammad, Sevigny, Jean, Lecka, Joanna, Kostakis, George E., Shah, Muhammad Shakil, Abbas, Ghulam, Raza, Rabia, al-Rashida, Mariya, European Journal of Medicinal Chemistry, 2013, 10.1016/J.EJMECH.2013.06.015
- The bovine aorta ATP-diphosphohydrolase, an ectoenzyme involved in the hydrolysis of P-2-purinoceptor agonists, Sévigny, Jean, 1995
- NTPDase1 Modulates Smooth Muscle Contraction in Mice Bladder by Regulating Nucleotide Receptor Activation Distinctly in Male and Female, Sevigny, J, Robaye, B, Pelletier, J, Kauffenstein, G, Babou Kammoe, RB, Biomolecules, 2021, 10.3390/biom11020147
- Expanding the Alkaline Phosphatase Inhibition, Cytotoxic and Proapoptotic Profile of Biscoumarin‐Iminothiazole and Coumarin‐Triazolothiadiazine Conjugates, Saeed, A, Sévigny, J, Lecka, J, Umar, MI, Ibrar, A, Ejaz, SA, Iqbal, J, ChemistrySelect, 2018, 10.1002/slct.201801863
- Identification, characterization, and immunolocalization of a nucleoside triphosphate diphosphohydrolase in pig liver, Beaudoin, AR, Sévigny, J, Gendron, FP, Grondin, G, Leclerc, MC, Archives of biochemistry and biophysics, 2000, 10.1006/abbi.2000.1800
- Extracellular nucleotide signaling in adult neural stem cells: synergism with growth factor-mediated cellular proliferation, Zimmermann, H, Robson, SC, Sévigny, J, Ikehara, Y, Gachet, C, Korf, HW, Schomerus, C, Füllgrabe, M, Braun, N, Shukla, V, Mishra, SK, Development (Cambridge, England), 2006, 10.1242/dev.02233
- Antenatal Dexamethasone Treatment Induces Sex-dependent Upregulation of NTPDase1/CD39 and Ecto-5'-nucleotidase/CD73 in the Rat Fetal Brain, Laketa, D, Nedeljkovic, N, Sevigny, J, Nestorovic, N, Ristic, N, Trifunovic, S, Stevanovic, I, Lavrnja, I, Manojlovic-Stojanoski, M, Cellular and molecular neurobiology, 2021, 10.1007/s10571-021-01081-8
- New one-pot synthesis of N-fused isoquinoline derivatives by palladium-catalyzed C-H arylation: potent inhibitors of nucleotide pyrophosphatase-1 and -3, Langer, P, Iqbal, J, Sevigny, J, Lecka, J, Villinger, A, Ehlers, P, Khan, SU, Ejaz, SA, Ausekle, E, Organic & biomolecular chemistry, 2016, 10.1039/c6ob02236g
- Design, synthesis and in vitro evaluation of novel sulfonylurea and sulfonylthiourea as ectonucleotidases inhibitors, Jamshed Iqbal, Jean Sévigny, Julie Pelletier, Abdul Rehman Khan, Abdul Hameed, Abdullah Yahya Abdullah Alzahrani, Results in Chemistry, 2024, 10.1016/j.rechem.2024.101548
- Epidermal melanocytes metabolize extracellular nucleotides by purinergic enzymes, Marcia Wink, Silvya Stuchi Maria-Engler, Tiago Franco de Oliveira, Jean Sévigny, Jéssica Gonçalves Azevedo, Liliana Sous Naasani, Biochemistry and Cell Biology, 2023, 10.1139/bcb-2022-0058
- Tricyclic coumarin sulphonate derivatives with alkaline phosphatase inhibitory effects: in vitro and docking studies, Oh, CH, Sevigny, J, Lecka, J, Ejaz, SA, El-Gamal, MI, Iqbal, J, Journal of enzyme inhibition and medicinal chemistry, 2018, 10.1080/14756366.2018.1428193
- Blockade of P2Y receptors prevents cirrhosis due to carbon tetrachloride but not extrahepatic bile duct ligation, Sevigny, J, Robson, S, Kruglov, EA, Dranoff, JA, The FASEB Journal, 2004
- C-terininal splicing of NTPDase2 provides distinctive catalytic properties, cellular distribution and enzyme regulation, Thorne, PR, Soeller, C, Sevigny, J, Robson, SC, Zimmermann, H, Braun, N, Housley, GD, Vlajkovic, SM, Wang, CJF, Biochemical Journal, 2005, 10.1042/BJ20040852
- Development and characterization of CD73-siRNA-loaded nanoemulsion: effect on C6 glioma cells and primary astrocytes, Braganhol, E, Teixeira, HF, Battastini, AMO, Spanevello, RM, Sevigny, J, Stefani, MA, Berenguer, AM, Azambuja, JH, Bruxel, F, Teixeira, FC, Pharmaceutical development and technology, 2020, 10.1080/10837450.2019.1705485
- The ecto-ATPase NTPDase2 is associated with a subset of astrocytic cells in the germinal zones of the adult rodent brain., Sévigny, Jean, 2003
- Inhibition of vascular ectonucleotidase activities by the pro-drugs ticlopidine and clopidogrel favours platelet aggregation, Sevigny, J, Rana, MS, Lecka, J, British journal of pharmacology, 2010, 10.1111/j.1476-5381.2010.00951.x
- Highly potent and selective ectonucleotide pyrophosphatase/phosphodiesterase I inhibitors based on an adenosine 5'-(α or γ)-thio-(α,β- or β,γ)-methylenetriphosphate scaffold, Fischer, B, Sevigny, J, Senderowitz, H, Weisman, GA, Camden, J, Kenigsberg, S, Reiser, G, Forster, D, Ben-David, G, Gilad, Y, Lecka, J, Nadel, Y, Journal of medicinal chemistry, 2014, 10.1021/jm500196c
- Blockade of CD73 delays glioblastoma growth by modulating the immune environment, Braganhol, E, Teixeira, HF, Figueiro, F, Battastini, AMO, Stefani, MA, Wink, MR, Sevigny, J, Scholl, JN, Lenz, GS, Roliano, GG, Beckenkamp, LR, Iser, IC, Michels, LR, Schuh, RS, Azambuja, JH, Cancer immunology, immunotherapy : CII, 2020, 10.1007/s00262-020-02569-w
- Thromboregulatory potential of endothelial CD39/nucleoside triphosphate diphosphohydrolase: modulation of purinergic signalling in platelets, Enjyoji, K, Guckelberger, O, Imai, M, Sévigny, J, Robson, SC, Emerging therapeutic targets, 2000, 10.1517/14728222.4.2.155
- Structural and post-translational modifications of ATP diphosphohydrolase/CD39, Robson, S. C., Kaczmarek, E., Esch, J. S. A., Sevigny, J., 1998
- Ectonucleotidases in the kidney, Sevigny, J, Vekaria, RM, Shirley, DG, Purinergic signalling, 2009, 10.1007/s11302-009-9152-4
- NTPDase8, Sévigny, J, UCSD-Nature Molecule Pages, 2007, 10.1038/mp.a003955.01
- Comparative hydrolysis of extracellular adenine nucleotides and adenosine in synaptic membranes from porcine brain cortex, hippocampus, cerebellum and medulla oblongata, Komoszynski, M, Sévigny, J, Kukulski, F, Brain research, 2004, 10.1016/j.brainres.2004.09.044
- Extracellular nucleosides and nucleotides regulate liver functions via a complex system of membrane proteins, Sevigny, J, Fausther, M, Comptes rendus biologies, 2011, 10.1016/j.crvi.2010.12.005
- Identification and immunolocalization of two isoforms of ATP-diphosphohydrolase (ATPDase) in the pig immune system, Beaudoin, AR, D'Orléans-Juste, P, Rousseau, E, Gendron, FP, Sévigny, J, Grondin, G, Benrezzak, O, Archives of biochemistry and biophysics, 1999, 10.1006/abbi.1999.1401
- Ecto-5'-Nucleotidase Overexpression Reduces Tumor Growth in a Xenograph Medulloblastoma Model, Ulrich, H, Battastini, AM, Sevigny, J, Lecka, J, Roesler, R, Abujamra, AL, Figueiro, F, Oliveira, FH, Dietrich, F, Souza, HD, Pillat, MM, Cappellari, AR, PloS one, 2015, 10.1371/journal.pone.0140996
- Tumor-neutrophil crosstalk promotes in vitro and in vivo glioblastoma progression, Elizandra Braganhol, Nils Ludwig, Niels O. S. Câmara, Jean Sévigny, Anelise B. Araújo, Paulo V. Worm, Marcia R. Wink, Marcelo L. Lamers, Fernanda Visioli, Ana H. Paz, Giselle M. Kroeff, Aline M. de Abreu, Gabriela S. Lenz, Aline S. Rubenich, Nicolly E. Gelsleichter, Leonardo F. Diel, Kerolainy A. Gadelha, Maico T. Cunha, Jordana L. Domagalski, Gabriela F.S. Gentil, Fernanda C. Teixeira, Eloisa M. da Silva, Luisa M. Silva, Paulo J. Basso, Mariana R. Aubin, Natalia Omizzollo, Priscila O. de Souza, Dominique S. Rubenich, Frontiers in Immunology, 2023, 10.3389/fimmu.2023.1183465
- Identification of Small Molecule Sulfonic Acids as Ecto-5 '-Nucleotidase Inhibitors, Iqbal, Jamshed, Sevigny, Jean, Lecka, Joanna, Saeed, Aamer, Raza, Rabia, Medicinal Chemistry, 2012
- CD39 may impact clopidrogrel pharmacodynamics, Sévigny, J, Martin-Satué, M, Fausther, M, Lecka, J, Austin journal of clinical immunology, 2014
- Localization of CD39L1/vascular NTP diphosphohydrolase (NTPDase2) in murine kidney., Robson, S. C., Sevigny, J., Isaac, J., Kishore, B. K., 2002
- P21(Waf1/Cip1) in endothelial cell survival, Sévigny, J, Aoudjit, F, Cardiovascular research, 2004, 10.1016/j.cardiores.2004.01.003
- Global deletion of NTPDase3 protects against diet-induced obesity by increasing basal energy metabolism, Perez-Matos, MC, Jiang, ZG, Robson, SC, Maratos-Flier, E, Sévigny, J, Enjyoji, K, Tiwari-Heckler, S, Csizmadia, E, Yalcin, Y, Huang, J, Pelletier, J, Mitsuhashi, S, Feldbrügge, L, Syed, I, Singhal, G, Tran, S, S, hu, B, Metabolism: clinical and experimental, 2021, 10.1016/j.metabol.2021.154731
- Endothelial P2Y(2) receptor regulates LPS-induced neutrophil transendothelial migration in vitro, Sevigny, Jean, Tremblay, Alain, Fausther, Michel, Bahrami, Fariborz, Ben Yebdri, Fethia, Kukulski, Filip, Molecular Immunology, 2010, 10.1016/J.MOLIMM.2009.11.020
- Nucleoside triphosphate diphosphohydrolase-2 (NTPDase2/CD39L1) is the dominant ectonucleotidase expressed by rat astrocytes, Robson, SC, Battastini, AM, Sévigny, J, Libermann, TA, Zerbini, LF, Lenz, G, Tamajusuku, AS, Braganhol, E, Wink, MR, Neuroscience, 2006, 10.1016/j.neuroscience.2005.11.039
- Efficient one-pot synthesis of 5-perfluoroalkylpyrazoles by cyclization of hydrazone dianions, Langer, P, Sevigny, J, Lecka, J, Iqbal, J, Dang, TT, Hung, TQ, Ejaz, SA, Ngo, TN, Organic & biomolecular chemistry, 2015, 10.1039/c5ob01151e
- NTPDase1 (CD39) controls nucleotide dependent vasomotion in mouse, Thorin, Eric, Marceau, Francois, D'Orleans-Juste, Pedro, Robaye, Bernard, Thorin-Trescases, Nathalie, Drouin, Annick, Fuerstenau, Cristina Ribas, Kauffenstein, Gilles, Sevigny, Jean, 2010
- Identification of a novel ecto-nucleoside triphoshphate diphosphohydrolase from the liver of the little skate Raja erinacea, Sevigny, J., Zarrella, K., Petell, L., Kruglov, E., Dranoff, J. A., 2002
- Distribution, cloning, and characterization of porcine nucleoside triphosphate diphosphohydrolase-1, Sévigny, J, Benrezzak, O, Beaudoin, AR, Kittel, A, uffel, L, V, Lemmens, R, European journal of biochemistry, 2000, 10.1046/j.1432-1327.2000.01462.x
- Fluorescence polarization immunoassays for monitoring nucleoside triphosphate diphosphohydrolase (NTPDase) activity, Muller, CE, Sevigny, J, Lecka, J, Baqi, Y, Fiene, A, The Analyst, 2015, 10.1039/c4an01694g
- Ecto-nucleotidases distribution in human cyclic and postmenopausic endometrium, a, IG, de Ar, Martin-Satue, M, Condom, E, Sevigny, J, Ponce, J, Taco, MD, Torrejon-Escribano, B, Vidal, A, Aliagas, E, Purinergic signalling, 2013, 10.1007/s11302-012-9345-0
- Methotrexate up-regulates ecto-5'-nucleotidase/CD73 and reduces the frequency of T lymphocytes in the glioblastoma microenvironment, Battastini, AM, Pohlmann, AR, Guterres, SS, Sevigny, J, Pettenuzzo, LF, Moritz, CE, rey, EH, J, Mendes, FB, Rockenbach, L, Bergamin, LS, de Oliveira, CP, Figueiro, F, Purinergic signalling, 2016, 10.1007/s11302-016-9505-8
- Role of Nucleotides, Ectonucleotidases and P2 Receptors in Vascular Contraction and Myogenic Tone, Henrion, D., Sevigny, J., Robaye, B., Thorin, E., Loufrani, L., Drouin, A., Kauffenstein, G., 2010
- ATP-diphosphohydrolases, process of purification thereof and process of producing thereof by recombinant technology, Beaudoin Adrien, R., Jean Sévigny, 2004
- CD73 Downregulation Decreases In Vitro and In Vivo Glioblastoma Growth, Braganhol, E, Teixeira, HF, Stefani, MA, Wink, MR, Sevigny, J, Spanevello, RM, de Oliveira, FH, Scholl, JN, Battastini, AMO, Figueiro, F, es, MC, Fern, Iser, IC, Beckenkamp, LR, Gelsleichter, NE, Azambuja, JH, Molecular neurobiology, 2019, 10.1007/s12035-018-1240-4
- Design and synthesis of new adamantyl derivatives as promising antiproliferative agents., El-Gamal MI, Al-Tel TH, Iqbal J, Sévigny J, Pelletier J, Gelsleichter NE, El-Awady R, Oh CH, Abdel-Maksoud MS, Menon V, El-Gamal R, Hanan S. Anbar, Ullah S, AlKubaisi BO, Zaraei SO, Shahin AI, European journal of medicinal chemistry, 2022, 10.1016/j.ejmech.2022.114958
- Generation and characterization of a monoclonal antibody as the first specific inhibitor of human NTPDase3, Sevigny, J., Kirley, T. L., Kuenzli, B., Tremblay, A., Pelletier, J., Ivanenkov, V. V., Fausther, M., Munkonda, M. N., The FEBS Journal, 2010
- Characterization of hepatic stellate cells, portal fibroblasts, and mesothelial cells in normal and fibrotic livers, Asahina, K, Sevigny, J, French, SW, Wang, KS, Zagory, JA, Li, Y, Lua, I, Journal of hepatology, 2016, 10.1016/j.jhep.2016.01.010
- Bisthioureas of pimelic acid and 4-methylsalicylic acid derivatives as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP) and intestinal alkaline phosphatase (IAP): Synthesis and molecular docking studies, Iqbal, J, Sevigny, J, Pelletier, J, Saeed, A, Zaib, S, Mahmood, A, Saeed, K, Mumtaz, A, Bioorganic chemistry, 2020, 10.1016/j.bioorg.2020.103996
- NTPDase8 protects mice from intestinal inflammation by limiting P2Y6 receptor activation: identification of a new pathway of inflammation for the potential treatment of IBD, Sévigny, J, Jobin, C, Robaye, B, Brochu, G, Vallières, L, Dumas, A, Gomes Marconato, D, Pelletier, J, Lecka, J, Salem, M, Gut, 2022, 10.1136/gutjnl-2020-320937
- Supplement comprising of laccase and citric acid as an alternative for antibiotics: In vitro triggers of melanin production, Avalos-Ramirez, A, Sévigny, J, ez-Galan, L, Hern, Brar, SK, Salem, M, Suresh, G, Lecka, J, Chaali, M, Engineering in life sciences, 2018, 10.1002/elsc.201700160
- Role of ecto-NTPDases on UDP-sensitive P2Y(6) receptor activation during osteogenic differentiation of primary bone marrow stromal cells from postmenopausal women, Correia-de-Sá, P, Sévigny, J, Neves, JM, Freitas, R, Pelletier, J, Ferreirinha, F, Magalhães-Cardoso, MT, Costa, MA, Noronha-Matos, JB, Journal of cellular physiology, 2012, 10.1002/jcp.23014
- Nucleoside-(5'→P) methylenebisphosphonodithioate analogues: synthesis and chemical properties, Fischer, B, Sevigny, J, Amir, A, Lecka, J, Nadel, Y, Meltzer, D, The Journal of organic chemistry, 2013, 10.1021/jo400931n
- Ticlopidine in its prodrug form is a selective inhibitor of human NTPDase1, Sevigny, J, Kunzli, B, Fausther, M, Lecka, J, Mediators of inflammation, 2014, 10.1155/2014/547480
- 3-(5-(Benzylideneamino)thiazol-3-yl)-2Hchromen-2-ones: a new class of alkaline phosphatase and ecto-5'-nucleotidase inhibitors, Iqbal, J, Sévigny, J, Lecka, J, al-Rashida, M, Hassan, S, Shehzad, M, Ejaz, SA, Saeed, A, RSC advances, 2016
- Synthesis, Characterization, Interactions, and Immunomodulatory Function of Ectonucleotidase CD39/CD73 Inhibitor 8-Butylthioadenosine 5′-Monophosphate, Christa E. Müller, Norbert Sträter, Vigneshwaran Namasivayam, Eva Tolosa, Tobias Claff, Julian Schulze zur Wiesch, Jean Sévigny, Julie Pelletier, Vittoria Lopez, Kilian Keetz, Susanne Moschütz, Riekje Winzer, Laura Schäkel, Helay Baburi, Salahuddin Mirza, Chunyang Bi, ACS Pharmacology & Translational Science, 2025, 10.1021/acsptsci.5c00126
- Stomach-derived human insulin-secreting organoids restore glucose homeostasis, Qiao Zhou, Jean Sévigny, David T. Breault, Jian Zhu, Hyunkee Kim, Jiaqi Lu, Christoph Pertl, Sanlan Li, Jonathan L. Colarusso, Ying Lan, Jiaoyue Zhang, Wei Gu, Xiaofeng Huang, Nature Cell Biology, 2023, 10.1038/s41556-023-01130-y
- Suppression of ATP diphosphohydrolase/CD39 in human vascular endothelial cells, Robson, SC, Schulte am Esch, J, Csizmadia, E, Guckelberger, O, Goepfert, C, Sévigny, J, Koziak, K, Kaczmarek, E, Imai, M, Biochemistry, 1999, 10.1021/bi990543p
- Mutagenesis of N-glycosylation sites of human ecto-ATPase (E-NTPDase 2), Knowles, A. F., Sevigny, J., Shindo, K., 2004
- Exploring chromone sulfonamides and sulfonylhydrazones as highly selective ectonucleotidase inhibitors: Synthesis, biological evaluation and in silico study, Mariya al-Rashida, Jamshed Iqbal, Jean Sévigny, Julie Pelletier, Habsah Mohamad, Asnuzilawati Asari, Abdul Hameed, Muhammad Siraj Khan Jadoon, Abid Mahmood, Muhammad Saeed, Hafiza Amna Younus, Bioorganic Chemistry, 2023, 10.1016/j.bioorg.2023.106450
- NTPDase1 and NTPDase2 immunolocalization in mouse cochlea: Implications for regulation of P2 receptor signaling, Housley, GD, Robson, SC, Sevigny, J, Thorne, PR, Vlajkovic, SM, Journal of Histochemistry & Cytochemistry, 2002, 10.1177/002215540205001102
- Noise exposure induces up-regulation of ecto-nucleoside triphosphate diphosphohydrolases 1 and 2 in rat cochlea, Thorne, PR, Wang, CJH, Sevigny, J, Robson, SC, Munoz, DJB, Housley, GD, Vlajkovic, SM, Neuroscience, 2004, 10.1016/J.NEUROSCIENCE.2004.04.023
- Domino reactions of chromone-3-carboxylic acids with aminoheterocycles: synthesis of heteroannulated pyrido[2,3-c]coumarins and their optical and biological activity, Langer, P, Sévigny, J, Lecka, J, Villinger, A, Ivanov, A, Lochbrunner, S, Friedrich, A, Iqbal, J, Khan, SU, Ejaz, SA, Hassan, S, Chirkina, E, Janke, J, Miliutina, M, European journal of organic chemistry, 2017, 10.1002/ejoc.201701276
Contribution à l'enseignement aux cycles supérieurs
Étudiant(e)s dirigé(e)s*
Depuis 2020/06- Nicolly Espindola Gelsleichter - Doctorat - En cours
- Ouitchédé Gilles Danvide - Maîtrise avec mémoire - En cours
- Sina Rahimi Dizaji - Doctorat - En cours
- Alessandra Guedes Manzoni - Doctorat - En cours
- Radu Turcitu - Doctorat - En cours
- Mabrouka Salem - Post-doctorat - En cours
- Fatemeh Salarpour - Doctorat - En cours
- Abdoul Karim Ouattara - Doctorat - En cours
- Chakib Hamoudi - Maîtrise avec mémoire - 2020/09
- Romuald Brice Babou Kammoe - Maîtrise avec mémoire - 2021/01
Encadrement d'étudiant(e)s
Direction de recherche dans les domaines suivants :
- Biologie cellulaire et moléculaire
- Médecine moléculaire
- Microbiologie-immunologie
- Sciences cliniques et biomédicales
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