Jean Sévigny

The Purinergic Receptor P2X4 Promotes Th17 Activation and the Development of Arthritis, Chakib Hamoudi, Chenqi Zhao, Amna Abderrazak, Mabrouka Salem, Paul R. Fortin, Jean Sévigny, Fawzi Aoudjit, The Journal of Immunology, 2022, 10.4049/jimmunol.2100550

NTPDase8 protects mice from intestinal inflammation by limiting P2Y6 receptor activation: identification of a new pathway of inflammation for the potential treatment of IBD, Mabrouka Salem, Joanna Lecka, Julie Pelletier, Danielle Gomes Marconato, Aline Dumas, Luc Vallières, Gaetan Brochu, Bernard Robaye, Christian Jobin, Jean Sévigny, Gut, 2022, 10.1136/gutjnl-2020-320937

Synthesis, characterization and biological evaluation of thiadiazole amide derivatives as nucleoside triphosphate diphosphohydrolases (NTPDases) inhibitors, Sadia Abbas, Saira Afzal, Humaira Nadeem, Dilawar Hussain, Peter Langer, Jean Sévigny, Zaman Ashraf, Jamshed Iqbal, Bioorganic Chemistry, 2022, 10.1016/j.bioorg.2021.105456

2‐Substituted thienotetrahydropyridine derivatives: Allosteric ectonucleotidase inhibitors, Laura Schäkel, Salahuddin Mirza, Markus Pietsch, Sang‐Yong Lee, Tim Keuler, Katharina Sylvester, Julie Pelletier, Jean Sévigny, Thanigaimalai Pillaiyar, Vigneshwaran Namasivayam, Michael Gütschow, Christa E. Müller, Archiv der Pharmazie, 2021, 10.1002/ardp.202100300

Extracellular ectonucleotidases are differentially regulated in murine tissues and human polymorphonuclear leukocytes during sepsis and inflammation, Clarissa B. Haas, Marianna Lovászi, Pál Pacher, Priscila Oliveira de Souza, Julie Pelletier, Rafael Olive Leite, Jean Sévigny, Zoltán Németh, Elizandra Braganhol, György Haskó, Purinergic Signalling, 2021, 10.1007/s11302-021-09819-1

Divergent synthesis and elaboration of structure activity relationship for quinoline derivatives as highly selective NTPDase inhibitor, Amna Murtaza, Saira Afzal, Gohar Zaman, Aamer Saeed, Julie Pelletier, Jean Sévigny, Jamshed Iqbal, Abbas Hassan, Bioorganic Chemistry, 2021, 10.1016/j.bioorg.2021.105240

Extracellular ATP hydrolysis in Caco-2 human intestinal cell line, J. Schachter, C.L. Alvarez, Z. Bazzi, M.P. Faillace, G. Corradi, C. Hattab, D.E. Rinaldi, R. Gonzalez-Lebrero, M. Pucci Molineris, J. Sévigny, M.A. Ostuni, P.J. Schwarzbaum, Biochimica et Biophysica Acta (BBA) - Biomembranes, 2021, 10.1016/j.bbamem.2021.183679

Identification and Expression Analysis of CD73 Inhibitors in Cervical Cancer, Jamshed Iqbal, Ayesha Basharat, Sehrish Bano, Syed Mobasher Ali Abid, Julie Pelletier, Jean Sévigny, Medicinal Chemistry, 2021, 10.2174/1573406416666200925141703

New insights into cytotoxic mechanisms of bozepinib against glioblastoma, Amanda de Fraga Dias, Juliete Nathali Scholl, Cesar Eduardo Jacintho Moritz, Luciano Porto Kagami, Gustavo Machado das Neves, Vera Lúcia Eifler-Lima, Olga Cruz-López, Ana Conejo-García, Jean Sévigny, Ana Maria Oliveira Battastini, Joaquin María Campos, Fabrício Figueiró, European Journal of Pharmaceutical Sciences, 2021, 10.1016/j.ejps.2021.105823

Synthesis, In-vitro evaluation and molecular docking studies of oxoindolin phenylhydrazine carboxamides as potent and selective inhibitors of ectonucleoside triphosphate diphosphohydrolase (NTPDase), Saira Afzal, Mariya al-Rashida, Abdul Hameed, Julie Pelletier, Jean Sévigny, Jamshed Iqbal, Bioorganic Chemistry, 2021, 10.1016/j.bioorg.2021.104957

Global deletion of NTPDase3 protects against diet-induced obesity by increasing basal energy metabolism, Bynvant Sandhu, Maria C. Perez-Matos, Stephanie Tran, Garima Singhal, Ismail Syed, Linda Feldbrügge, Shuji Mitsuhashi, Julie Pelletier, Jinhe Huang, Yusuf Yalcin, Eva Csizmadia, Shilpa Tiwari-Heckler, Keiichi Enjyoji, Jean Sévigny, Eleftheria Maratos-Flier, Simon C. Robson, Z. Gordon Jiang, Metabolism, 2021, 10.1016/j.metabol.2021.154731

Synthesis, biological evaluation, and docking studies of novel pyrrolo[2,3-b]pyridine derivatives as both ectonucleotide pyrophosphatase/phosphodiesterase inhibitors and antiproliferative agents, Saif Ullah, Mohammed I. El-Gamal, Randa El-Gamal, Julie Pelletier, Jean Sévigny, Mahmoud K. Shehata, Hanan S. Anbar, Jamshed Iqbal, European Journal of Medicinal Chemistry, 2021, 10.1016/j.ejmech.2021.113339

Characterization of the Endometrial MSC Marker Ectonucleoside Triphosphate Diphosphohydrolase-2 (NTPDase2/CD39L1) in Low- and High-Grade Endometrial Carcinomas: Loss of Stromal Expression in the Invasive Phenotypes, Aitor Rodríguez-Martínez, Carla Trapero, August Vidal, Josep Maria Piulats, Inmaculada Gómez de Aranda, Jean Sévigny, Maria Eulàlia Fernández-Montolí, Jordi Ponce, Xavier Matias-Guiu, Mireia Martín-Satué, Journal of Personalized Medicine, 2021, 10.3390/jpm11050331

Neutrophils: fast and furious—the nucleotide pathway, Dominique S. Rubenich, Priscila O. de Souza, Natalia Omizzollo, Gabriela S. Lenz, Jean Sevigny, Elizandra Braganhol, Purinergic Signalling, 2021, 10.1007/s11302-021-09786-7

Antenatal Dexamethasone Treatment Induces Sex-dependent Upregulation of NTPDase1/CD39 and Ecto-5ʹ-nucleotidase/CD73 in the Rat Fetal Brain, Milica Manojlovic-Stojanoski, Irena Lavrnja, Ivana Stevanovic, Svetlana Trifunovic, Natasa Ristic, Natasa Nestorovic, Jean Sévigny, Nadezda Nedeljkovic, Danijela Laketa, Cellular and Molecular Neurobiology, 2021, 10.1007/s10571-021-01081-8

Influence of NSAIDs and methotrexate on CD73 expression and glioma cell growth, Daniela Vasconcelos Lopes, Amanda de Fraga Dias, Luiz Fernando Lopes Silva, Juliete Nathali Scholl, Jean Sévigny, Ana Maria Oliveira Battastini, Fabrício Figueiró, Purinergic Signalling, 2021, 10.1007/s11302-021-09775-w

NTPDase1 Modulates Smooth Muscle Contraction in Mice Bladder by Regulating Nucleotide Receptor Activation Distinctly in Male and Female, Romuald Brice Babou Kammoe, Gilles Kauffenstein, Julie Pelletier, Bernard Robaye, Jean Sévigny, Biomolecules, 2021, 10.3390/biom11020147

Sulfated Polysaccharides from Macroalgae Are Potent Dual Inhibitors of Human ATP-Hydrolyzing Ectonucleotidases NPP1 and CD39, Vittoria Lopez, Laura Schäkel, H. J. Maximilian Schuh, Michael S. Schmidt, Salahuddin Mirza, Christian Renn, Julie Pelletier, Sang-Yong Lee, Jean Sévigny, Susanne Alban, Gerd Bendas, Christa E. Müller, Marine Drugs, 2021, 10.3390/md19020051

Evaluation of sulfonate and sulfamate derivatives possessing benzofuran or benzothiophene nucleus as inhibitors of nucleotide pyrophosphatases/phosphodiesterases and anticancer agents, Hanan S. Anbar, Randa El-Gamal, Saif Ullah, Seyed-Omar Zaraei, Mariya al-Rashida, Sumera Zaib, Julie Pelletier, Jean Sévigny, Jamshed Iqbal, Mohammed I. El-Gamal, Bioorganic Chemistry, 2020, 10.1016/j.bioorg.2020.104305

Functionalized Oxoindolin Hydrazine Carbothioamide Derivatives as Highly Potent Inhibitors of Nucleoside Triphosphate Diphosphohydrolases, Saira Afzal, Mariya al-Rashida, Abdul Hameed, Julie Pelletier, Jean Sévigny, Jamshed Iqbal, Frontiers in Pharmacology, 2020, 10.3389/fphar.2020.585876

Synthesis, Characterization, and In Silico Studies of Novel Spirooxindole Derivatives as Ecto-5′-Nucleotidase Inhibitors, Abida Ashraf, Zahid Shafiq, Muhammad Siraj Khan Jadoon, Muhammad Nawaz Tahir, Julie Pelletier, Jean Sevigny, Muhammad Yaqub, Jamshed Iqbal, ACS Medicinal Chemistry Letters, 2020, 10.1021/acsmedchemlett.0c00343

A Simple and Efficient Genetic Immunization Protocol for the Production of Highly Specific Polyclonal and Monoclonal Antibodies against the Native Form of Mammalian Proteins, Julie Pelletier, Hervé Agonsanou, Fabiana Manica, Elise G. Lavoie, Mabrouka Salem, Patrick Luyindula, Romuald Brice Babou Kammoe, Jean Sévigny, International Journal of Molecular Sciences, 2020, 10.3390/ijms21197074

Nucleotide Analog ARL67156 as a Lead Structure for the Development of CD39 and Dual CD39/CD73 Ectonucleotidase Inhibitors, Laura Schäkel, Constanze C. Schmies, Riham M. Idris, Xihuan Luo, Sang-Yong Lee, Vittoria Lopez, Salahuddin Mirza, The Hung Vu, Julie Pelletier, Jean Sévigny, Vigneshwaran Namasivayam, Christa E. Müller, Frontiers in Pharmacology, 2020, 10.3389/fphar.2020.01294

Synthesis, characterization, in vitro tissue-nonspecific alkaline phosphatase (TNAP) and intestinal alkaline phosphatase (IAP) inhibition studies and computational evaluation of novel thiazole derivatives, Hamid Aziz, Abid Mahmood, Sumera Zaib, Aamer Saeed, Zahid Shafiq, Julie Pelletier, Jean Sévigny, Jamshed Iqbal, Bioorganic Chemistry, 2020, 10.1016/j.bioorg.2020.104088

Synthesis, characterization, alkaline phosphatase inhibition assay and molecular modeling studies of 1-benzylidene-2-(4-tert- butylthiazol-2-yl) hydrazines, Hamid Aziz, Abid Mahmood, Sumera Zaib, Aamer Saeed, Hesham R. El-Seedi, Julie Pelletier, Jean Sévigny, Jamshed Iqbal, Journal of Biomolecular Structure and Dynamics, 2020, 10.1080/07391102.2020.1802336

Highly Potent and Selective Ectonucleoside Triphosphate Diphosphohydrolase (ENTPDase1, 2, 3 and 8) Inhibitors Having 2-substituted-7- trifluoromethyl-thiadiazolopyrimidones Scaffold, Saira Afzal, Sumera Zaib, Behzad Jafari, Peter Langer, Joanna Lecka, Jean Sévigny, Jamshed Iqbal, Medicinal Chemistry, 2020, 10.2174/1573406415666190614095821

Bisthioureas of pimelic acid and 4-methylsalicylic acid derivatives as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP) and intestinal alkaline phosphatase (IAP): Synthesis and molecular docking studies, Amara Mumtaz, Kiran Saeed, Abid Mahmood, Sumera Zaib, Aamer Saeed, Julie Pelletier, Jean Sévigny, Jamshed Iqbal, Bioorganic Chemistry, 2020, 10.1016/j.bioorg.2020.103996

Development of Anthraquinone Derivatives as Ectonucleoside Triphosphate Diphosphohydrolase (NTPDase) Inhibitors With Selectivity for NTPDase2 and NTPDase3, Younis Baqi, Mahmoud Rashed, Laura Schäkel, Enas M. Malik, Julie Pelletier, Jean Sévigny, Amelie Fiene, Christa E. Müller, Frontiers in Pharmacology, 2020, 10.3389/fphar.2020.01282

Synthesis and computational studies of highly selective inhibitors of human recombinant tissue non-specific alkaline phosphatase (h-TNAP): A therapeutic target against vascular calcification, Hina Andleeb, Muzammal Hussain, Syeda Abida Ejaz, Jean Sevigny, Muhammad Farman, Masoom Yasinzai, Jiancun Zhang, Jamshed Iqbal, Shahid Hameed, Bioorganic Chemistry, 2020, 10.1016/j.bioorg.2020.103999

Sulfonylhydrazones: Design, synthesis and investigation of ectonucleotidase (ALP & e5′NT) inhibition activities, Hafiza Amna Younus, Abdul Hameed, Abid Mahmood, Muhammad Siraj Khan, Muhammad Saeed, Farwa Batool, Asnuzilawati Asari, Habsah Mohamad, Julie Pelletier, Jean Sévigny, Jamshed Iqbal, Mariya al-Rashida, Bioorganic Chemistry, 2020, 10.1016/j.bioorg.2020.103827

The anti-inflammatory effect of resistance training in hypertensive women: the role of purinergic signaling, Mônica D. Lammers, Nyasmin M. Anéli, Gabriela G. de Oliveira, Sarah F.V. de Oliveira Maciel, Daniela Zanini, Aline Mânica, Débora T. de Resende e Silva, Margarete D. Bagatini, Jean Sévigny, Clodoaldo A. De Sá, Leandro H. Manfredi, Andréia M. Cardoso, Journal of Hypertension, 2020, 10.1097/hjh.0000000000002578

Immortalization of Mesenchymal Stromal Cells by TERT Affects Adenosine Metabolism and Impairs their Immunosuppressive Capacity, L. R. Beckenkamp, D. M. S. da Fontoura, V. G. Korb, R. P. de Campos, G. R. Onzi, I. C. Iser, A. P. S. Bertoni, J. Sévigny, G. Lenz, Márcia Rosângela Wink, Stem Cell Reviews and Reports, 2020, 10.1007/s12015-020-09986-5

Synthesis, biological evaluation, and docking studies of new pyrazole-based thiourea and sulfonamide derivatives as inhibitors of nucleotide pyrophosphatase/phosphodiesterase, Saif Ullah, Mohammed I. El-Gamal, Sumera Zaib, Hanan S. Anbar, Seyed-Omar Zaraei, Rawan M. Sbenati, Julie Pelletier, Jean Sévigny, Chang-Hyun Oh, Jamshed Iqbal, Bioorganic Chemistry, 2020, 10.1016/j.bioorg.2020.103783

Structural investigation on thiazolo[5,4-d]pyrimidines to obtain dual-acting blockers of CD73 and adenosine A2A receptor as potential antitumor agents, Flavia Varano, Daniela Catarzi, Fabrizio Vincenzi, Silvia Pasquini, Julie Pelletier, Juliana Lopes Rangel Fietto, Nicolly Espindola Gelsleichter, Marine Sarlandie, Audrey Guilbaud, Jean Sévigny, Katia Varani, Vittoria Colotta, Bioorganic & Medicinal Chemistry Letters, 2020, 10.1016/j.bmcl.2020.127067

Blockade of CD73 delays glioblastoma growth by modulating the immune environment, J. H. Azambuja, R. S. Schuh, L. R. Michels, I. C. Iser, L. R. Beckenkamp, G. G. Roliano, G. S. Lenz, J. N. Scholl, J. Sévigny, M. R. Wink, M. A. Stefani, A. M. O. Battastini, F. Figueiró, H. F. Teixeira, E. Braganhol, Cancer Immunology, Immunotherapy, 2020, 10.1007/s00262-020-02569-w

Characterization and antiproliferative activity of glioma-derived extracellular vesicles, Juliete Nathali Scholl, Amanda de Fraga Dias, Pauline Rafaela Pizzato, Daniela Vasconcelos Lopes, Cesar Eduardo Jacintho Moritz, Elisa Helena Farias Jandrey, Gabriele Dadalt Souto, Mariana Colombo, Francieli Rohden, Jean Sévigny, Adriana Raffin Pohlmann, Sílvia Stanisçuaski Guterres, Ana Maria Oliveira Battastini, Fabrício Figueiró, Nanomedicine, 2020, 10.2217/nnm-2019-0431

Opposing Effects of Adenosine and Inosine in Human Subcutaneous Fibroblasts May Be Regulated by Third Party ADA Cell Providers, Carina Herman-de-Sousa, Ana Rita Pinheiro, Diogo Paramos-de-Carvalho, Maria Adelina Costa, Fátima Ferreirinha, Teresa Magalhães-Cardoso, Severino Ribeiro, Julie Pelletier, Jean Sévigny, Paulo Correia-de-Sá, Cells, 2020, 10.3390/cells9030651

Imatinib mesylate affects extracellular ATP catabolism and expression of NTPDases in a chronic myeloid leukemia cell line, Julia Biz Willig, Débora Renz Barreto Vianna, Aline Beckenkamp, Liziane Raquel Beckenkamp, Jean Sévigny, Márcia Rosângela Wink, Andréia Buffon, Diogo André Pilger, Purinergic Signalling, 2020, 10.1007/s11302-019-09686-x

Synthesis and Nucleotide Pyrophosphatase/Phosphodiesterase Inhibition Studies of Carbohydrazides Based on Benzimidazole‐Benzothiazine Skeleton, Afshan Kanwal, Saif Ullah, Matloob Ahmad, Julie Pelletier, Sana Aslam, Sadia Sultan, Jean Sévigny, Mazhar Iqbal, Jamshed Iqbal, ChemistrySelect, 2020, 10.1002/slct.202003479

Synthesis of biphenyl oxazole derivatives via Suzuki coupling and biological evaluations as nucleotide pyrophosphatase/phosphodiesterase-1 and -3 inhibitors, Haseen Ahmad, Saif Ullah, Fouzia Rahman, Aamer Saeed, Julie Pelletier, Jean Sévigny, Abbas Hassan, Jamshed Iqbal, European Journal of Medicinal Chemistry, 2020, 10.1016/j.ejmech.2020.112759

Palladium-catalyzed synthesis and nucleotide pyrophosphatase inhibition of benzo[4,5]furo[3,2-b]indoles, Hoang Huy Do, Saif Ullah, Alexander Villinger, Joanna Lecka, Jean Sévigny, Peter Ehlers, Jamshed Iqbal, Peter Langer, Beilstein Journal of Organic Chemistry, 2019, 10.3762/bjoc.15.276

Impaired Expression of Ectonucleotidases in Ectopic and Eutopic Endometrial Tissue Is in Favor of ATP Accumulation in the Tissue Microenvironment in Endometriosis, Carla Trapero, August Vidal, Maria Eulàlia Fernández-Montolí, Buenaventura Coroleu, Francesc Tresserra, Pere Barri, Inmaculada Gómez de Aranda, Jean Sévigny, Jordi Ponce, Xavier Matias-Guiu, Mireia Martín-Satué, International Journal of Molecular Sciences, 2019, 10.3390/ijms20225532

Synthesis, biological evaluation, and docking studies of new raloxifene sulfonate or sulfamate derivatives as inhibitors of nucleotide pyrophosphatase/phosphodiesterase, Mohammed I. El-Gamal, Saif Ullah, Seyed-Omar Zaraei, Saquib Jalil, Sumera Zaib, Dana M. Zaher, Hany A. Omar, Hanan S. Anbar, Julie Pelletier, Jean Sévigny, Jamshed Iqbal, European Journal of Medicinal Chemistry, 2019, 10.1016/j.ejmech.2019.07.063

Concentrates of two subsets of extracellular vesicles from cow’s milk modulate symptoms and inflammation in experimental colitis, Abderrahim Benmoussa, Idrissa Diallo, Mabrouka Salem, Sara Michel, Caroline Gilbert, Jean Sévigny, Patrick Provost, Scientific Reports, 2019, 10.1038/s41598-019-51092-1

Design, synthesis and biological evaluation of trinary benzocoumarin-thiazoles-azomethines derivatives as effective and selective inhibitors of alkaline phosphatase, Pervaiz Ali Channar, Hina Irum, Abid Mahmood, Ghulam Shabir, Sumera Zaib, Aamer Saeed, Zaman Ashraf, Fayaz Ali Larik, Joanna Lecka, Jean Sévigny, Jamshed Iqbal, Bioorganic Chemistry, 2019, 10.1016/j.bioorg.2019.103137

Exacerbated intestinal inflammation in P2Y6 deficient mice is associated with Th17 activation, Mabrouka Salem, Mohammed-Amine El Azreq, Julie Pelletier, Bernard Robaye, Fawzi Aoudjit, Jean Sévigny, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2019, 10.1016/j.bbadis.2019.06.019

NTPDase1 and -2 are expressed by distinct cellular compartments in the mouse colon and differentially impact colonic physiology and function after DSS colitis, Vladimir Grubišić, Alberto L. Perez-Medina, David E. Fried, Jean Sévigny, Simon C. Robson, James J. Galligan, Brian D. Gulbransen, American Journal of Physiology-Gastrointestinal and Liver Physiology, 2019, 10.1152/ajpgi.00104.2019

Nasal Administration of Cationic Nanoemulsions as CD73-siRNA Delivery System for Glioblastoma Treatment: a New Therapeutical Approach, J. H. Azambuja, R. S. Schuh, L. R. Michels, N. E. Gelsleichter, L. R. Beckenkamp, I. C. Iser, G. S. Lenz, F. H. de Oliveira, G. Venturin, S. Greggio, J. C. daCosta, M. R. Wink, J. Sevigny, M. A. Stefani, A. M. O. Battastini, H. F. Teixeira, E. Braganhol, Molecular Neurobiology, 2019, 10.1007/s12035-019-01730-6

Probing the high potency of pyrazolyl pyrimidinetriones and thioxopyrimidinediones as selective and efficient non-nucleotide inhibitors of recombinant human ectonucleotidases, Hina Andleeb, Shahid Hameed, Syeda Abida Ejaz, Imtiaz Khan, Sumera Zaib, Joanna Lecka, Jean Sévigny, Jamshed Iqbal, Bioorganic Chemistry, 2019, 10.1016/j.bioorg.2019.03.067

Synthesis, biological evaluation, and molecular docking study of sulfonate derivatives as nucleotide pyrophosphatase/phosphodiesterase (NPP) inhibitors, Mohammad H. Semreen, Mohammed I. El-Gamal, Saif Ullah, Saquib Jalil, Sumera Zaib, Hanan S. Anbar, Joanna Lecka, Jean Sévigny, Jamshed Iqbal, Bioorganic & Medicinal Chemistry, 2019, 10.1016/j.bmc.2019.04.031

Characterization of soluble CD39 (SolCD39/NTPDase1) from PiggyBac nonviral system as a tool to control the nucleotides level, Liziane Raquel Beckenkamp, Isabele Cristiana Iser, Giovana Ravizzoni Onzi, Dieine Maira Soares da Fontoura, Ana Paula Santin Bertoni, Jean Sévigny, Guido Lenz, Márcia Rosângela Wink, Biochemical Journal, 2019, 10.1042/bcj20190040

Investigation of new quinoline derivatives as promising inhibitors of NTPDases: Synthesis, SAR analysis and molecular docking studies, Komal Hayat, Saira Afzal, Altaf Saeed, Amna Murtaza, Shafiq Ur Rahman, Khalid Mohammed Khan, Aamer Saeed, Sumera Zaib, Joanna Lecka, Jean Sévigny, Jamshed Iqbal, Abbas Hassan, Bioorganic Chemistry, 2019, 10.1016/j.bioorg.2019.03.019

The ectonucleoside triphosphate diphosphohydrolase-2 (NTPDase2) in human endometrium: a novel marker of basal stroma and mesenchymal stem cells, Carla Trapero, August Vidal, Aitor Rodríguez-Martínez, Jean Sévigny, Jordi Ponce, Buenaventura Coroleu, Xavier Matias-Guiu, Mireia Martín-Satué, Purinergic Signalling, 2019, 10.1007/s11302-019-09656-3

Identification of adenine-N9-(methoxy)ethyl-β-bisphosphonate as NPP1 inhibitor attenuates NPPase activity in human osteoarthritic chondrocytes, Molhm Nassir, Uri Arad, Sang-Yong Lee, Shani Journo, Salahuddin Mirza, Christian Renn, Herbert Zimmermann, Julie Pelletier, Jean Sévigny, Christa E. Müller, Bilha Fischer, Purinergic Signalling, 2019, 10.1007/s11302-019-09649-2

Induction of NTPDase1/CD39 by Reactive Microglia and Macrophages Is Associated With the Functional State During EAE, Marija Jakovljevic, Irena Lavrnja, Iva Bozic, Ana Milosevic, Ivana Bjelobaba, Danijela Savic, Jean Sévigny, Sanja Pekovic, Nadezda Nedeljkovic, Danijela Laketa, Frontiers in Neuroscience, 2019, 10.3389/fnins.2019.00410

Benzo[b]carbazolediones Synthesis and Inhibitory Effects on Nucleotide Pyrophosphatases/Phosphodiesterases, Hoang Huy Do, Syeda Abida Ejaz, Ricardo Molenda, Lars Ohlendorf, Alexander Villinger, Shafi Ullah Khan, Joanna Lecka, Jean Sévigny, Jamshed Iqbal, Peter Ehlers, Peter Langer, ChemistrySelect, 2019, 10.1002/slct.201803061

Ectonucleoside Triphosphate Diphosphohydrolase-3 Antibody Targets Adult Human Pancreatic β Cells for In Vitro and In Vivo Analysis, Diane C. Saunders, Marcela Brissova, Neil Phillips, Shristi Shrestha, John T. Walker, Radhika Aramandla, Greg Poffenberger, David K. Flaherty, Kevin P. Weller, Julie Pelletier, Tracy Cooper, Matt T. Goff, John Virostko, Alena Shostak, E. Danielle Dean, Dale L. Greiner, Leonard D. Shultz, Nripesh Prasad, Shawn E. Levy, Robert H. Carnahan, Chunhua Dai, Jean Sévigny, Alvin C. Powers, Cell Metabolism, 2019, 10.1016/j.cmet.2018.10.007

Schiff bases of tryptamine as potent inhibitors of nucleoside triphosphate diphosphohydrolases (NTPDases): Structure-activity relationship, Kanwal, Khalid Mohammed Khan, Uzma Salar, Saira Afzal, Abdul Wadood, Muhammad Taha, Shahnaz Perveen, Huma Khan, Joanna Lecka, Jean Sévigny, Jamshed Iqbal, Bioorganic Chemistry, 2019, 10.1016/j.bioorg.2018.10.046

Adenine-(methoxy)-ethoxy-Pα,α-dithio-triphosphate inhibits pathologic calcium pyrophosphate deposition in osteoarthritic human chondrocytes, Molhm Nassir, Salahuddin Mirza, Uri Arad, Sangyong Lee, Muhammad Rafehi, Isaac Yaw Attah, Christian Renn, Herbert Zimmermann, Julie Pelletier, Jean Sévigny, Christa E. Müller, Bilha Fischer, Organic & Biomolecular Chemistry, 2019, 10.1039/c9ob02199j

Development and characterization of CD73-siRNA-loaded nanoemulsion: effect on C6 glioma cells and primary astrocytes, Fernanda C. Teixeira, Fernanda Bruxel, Juliana H. Azambuja, Alexandre M. Berenguer, Marco A. Stefani, Jean Sévigny, Roselia M. Spanevello, Ana M. O. Battastini, Helder F. Teixeira, Elizandra Braganhol, Pharmaceutical Development and Technology, 2019, 10.1080/10837450.2019.1705485

Physical exercise prevents memory impairment in an animal model of hypertension through modulation of CD39 and CD73 activities and A2A receptor expression, Andréia Machado Cardoso, Leandro Henrique Manfredi, Daniela Zanini, Margarete Dulce Bagatini, Jessié Martins Gutierres, Fabiano Carvalho, Alain Tremblay, Adriane Belló-Klein, Maribel Antonello Rubin, Vera Maria Morsch, Jean Sévigny, Maria Rosa Chitolina Schetinger, Journal of Hypertension, 2019, 10.1097/hjh.0000000000001845

Structure-activity relationship study of NPP1 inhibitors based on uracil-N1-(methoxy)ethyl-β-phosphate scaffold, Molhm Nassir, Julie Pelletier, Uri Arad, Guillaume Arguin, Netaly Khazanov, Fernand-Pierre Gendron, Jean Sévigny, Hanoch Senderowitz, Bilha Fischer, European Journal of Medicinal Chemistry, 2019, 10.1016/j.ejmech.2019.111754

Ectonucleotidase Inhibitory and Redox Activity of Imidazole‐Based Organic Salts and Ionic Liquids, Veaceslav Boldescu, Natalia Sucman, Sidra Hassan, Jamshed Iqbal, Mariana Neamtu, Joanna Lecka, Jean Sévigny, Denis Prodius, Fliur Macaev, ChemMedChem, 2018, 10.1002/cmdc.201800520

Hybrid compounds from chalcone and 1,2-benzothiazine pharmacophores as selective inhibitors of alkaline phosphatase isozymes, Adnan Ashraf, Syeda Abida Ejaz, Shafiq Ur Rahman, Waseeq Ahmad Siddiqui, Muhammad Nadeem Arshad, Joanna Lecka, Jean Sévigny, Mohie E. Moustafa Zayed, Abdullah M. Asiri, Jamshed Iqbal, Christian G. Hartinger, Muhammad Hanif, European Journal of Medicinal Chemistry, 2018, 10.1016/j.ejmech.2018.09.063

Physical exercise prevents alterations in purinergic system and oxidative status in lipopolysaccharide‐induced sepsis in rats, Vanessa Valéria Miron, Nathieli Bianchin Bottari, Charles Elias Assmann, Naiara Stefanello, Pauline da Costa, Luana Paula Pelinson, Karine Paula Reichert, Anielen Dutra da Silva, Thauan Faccin Lopes, Ivana Beatrice Mânica da Cruz, Jean Sévigny, Vera Maria Morsch, Maria Rosa Chitolina Schetinger, Andréia Machado Cardoso, Journal of Cellular Biochemistry, 2018, 10.1002/jcb.27590

Synthesis of novel ( E )-1-(2-(2-(4(dimethylamino) benzylidene) hydrazinyl)-4-methylthiazol-5-yl)ethanone derivatives as ecto-5′-nucleotidase inhibitors, Sidra Hassan, Pervaiz Ali Channar, Fayaz Ali Larik, Aamer Saeed, Hamid Saeed Shah, Joanna Lecka, Jean Sévigny, Jamshed Iqbal, Royal Society Open Science, 2018, 10.1098/rsos.180837

Chemoselective Synthesis and Human Ecto‐5′‐nucleotidase Inhibitory Activity of 2‐Trifluoromethyl‐4,6‐diarylquinolines, Rodisnel P. Rivera, Sidra Hassan, Peter Ehlers, Joanna Lecka, Jean Sévigny, Eugenio T. Rodríguez, Jamshed Iqbal, Peter Langer, ChemistrySelect, 2018, 10.1002/slct.201800917

CD73 Downregulation Decreases In Vitro and In Vivo Glioblastoma Growth, J. H. Azambuja, N. E. Gelsleichter, L. R. Beckenkamp, I. C. Iser, M. C. Fernandes, F. Figueiró, A. M. O. Battastini, J. N. Scholl, F. H. de Oliveira, R. M. Spanevello, Jean Sévigny, M. R. Wink, M. A. Stefani, H. F. Teixeira, Elizandra Braganhol, Molecular Neurobiology, 2018, 10.1007/s12035-018-1240-4

Exploration of carboxy pyrazole derivatives: Synthesis, alkaline phosphatase, nucleotide pyrophosphatase/phosphodiesterase and nucleoside triphosphate diphosphohydrolase inhibition studies with potential anticancer profile, Pervaiz Ali Channar, Saira Afzal, Syeda Abida Ejaz, Aamer Saeed, Fayaz Ali Larik, Parvez Ali Mahesar, Joanna Lecka, Jean Sévigny, Mauricio F. Erben, Jamshed Iqbal, European Journal of Medicinal Chemistry, 2018, 10.1016/j.ejmech.2018.07.002

Deazapurine Analogues Bearing a 1H-Pyrazolo[3,4-b]pyridin-3(2H)-one Core: Synthesis and Biological Activity, Linda Supe, Saira Afzal, Abid Mahmood, Syeda Abida Ejaz, Martin Hein, Viktor O. Iaroshenko, Alexander Villinger, Joanna Lecka, Jean Sévigny, Jamshed Iqbal, Peter Langer, European Journal of Organic Chemistry, 2018, 10.1002/ejoc.201800163

Distinctive inhibition of alkaline phosphatase isozymes by thiazol‐2‐ylidene‐benzamide derivatives: Functional insights into their anticancer role, Syeda Abida Ejaz, Aamer Saeed, Syed Jawad Ali Shah, Abdul Hameed, Joanna Lecka, Jean Sévigny, Jamshed Iqbal, Journal of Cellular Biochemistry, 2018, 10.1002/jcb.26692

Highly Selective and Potent Ectonucleotide Pyrophosphatase-1 (NPP1) Inhibitors Based on Uridine 5′-Pα,α-Dithiophosphate Analogues, Vadim Zelikman, Julie Pelletier, Luba Simhaev, Aviad Sela, Fernand-Pierre Gendron, Guillaume Arguin, Hanoch Senderowitz, Jean Sévigny, Bilha Fischer, Journal of Medicinal Chemistry, 2018, 10.1021/acs.jmedchem.7b01906

Supplement comprising of laccase and citric acid as an alternative for antibiotics:In vitrotriggers of melanin production, Mona Chaali, Joanna Lecka, Gayatri Suresh, Mabrouka Salem, Satinder Kaur Brar, Leticia Hernandez-Galan, Jean Sévigny, Antonio Avalos-Ramirez, Engineering in Life Sciences, 2018, 10.1002/elsc.201700160

Tricyclic coumarin sulphonate derivatives with alkaline phosphatase inhibitory effects: in vitro and docking studies, Jamshed Iqbal, Mohammed I. El-Gamal, Syeda Abida Ejaz, Joanna Lecka, Jean Sévigny, Chang-Hyun Oh, Journal of Enzyme Inhibition and Medicinal Chemistry, 2018, 10.1080/14756366.2018.1428193

4-Aminopyridine based amide derivatives as dual inhibitors of tissue non-specific alkaline phosphatase and ecto-5′-nucleotidase with potential anticancer activity, Sidra Hassan, Syeda Abida Ejaz, Aamer Saeed, Muddasar Shehzad, Shafi Ullah Khan, Joanna Lecka, Jean Sévigny, Ghulam Shabir, Jamshed Iqbal, Bioorganic Chemistry, 2018, 10.1016/j.bioorg.2017.11.013

P2Y6 Receptors Regulate CXCL10 Expression and Secretion in Mouse Intestinal Epithelial Cells, Mabrouka Salem, Alain Tremblay, Julie Pelletier, Bernard Robaye, Jean Sévigny, Frontiers in Pharmacology, 2018, 10.3389/fphar.2018.00149

Ecto-5′-nucleotidase/CD73 contributes to the radiosensitivity of T24 human bladder cancer cell line, Fabrícia Dietrich, Fabrício Figueiró, Eduardo Cremonese Filippi-Chiela, Angélica Regina Cappellari, Liliana Rockenbach, Alain Tremblay, Patrícia Boni de Paula, Rafael Roesler, Aroldo Braga Filho, Jean Sévigny, Fernanda Bueno Morrone, Ana Maria Oliveira Battastini, Journal of Cancer Research and Clinical Oncology, 2018, 10.1007/s00432-017-2567-3

2-Substituted 7-trifluoromethyl-thiadiazolopyrimidones as alkaline phosphatase inhibitors. Synthesis, structure activity relationship and molecular docking study, Behzad Jafari, Meirambek Ospanov, Syeda Abida Ejaz, Nazym Yelibayeva, Shafi Ullah Khan, Sayyeda Tayyeba Amjad, Sayfidin Safarov, Zharylkasyn A. Abilov, Mirgul Zh. Turmukhanova, Sergey N. Kalugin, Peter Ehlers, Joanna Lecka, Jean Sévigny, Jamshed Iqbal, Peter Langer, European Journal of Medicinal Chemistry, 2018, 10.1016/j.ejmech.2017.11.068

A domino reaction of 3-chlorochromones with aminoheterocycles. Synthesis of pyrazolopyridines and benzofuropyridines and their optical and ecto-5′-nucleotidase inhibitory effects, Mariia Miliutina, Julia Janke, Sidra Hassan, Sumera Zaib, Jamshed Iqbal, Joanna Lecka, Jean Sévigny, Alexander Villinger, Aleksej Friedrich, Stefan Lochbrunner, Peter Langer, Organic & Biomolecular Chemistry, 2018, 10.1039/c7ob02729j

Development of a selective and highly sensitive fluorescence assay for nucleoside triphosphate diphosphohydrolase1 (NTPDase1, CD39), Sang-Yong Lee, Xihuan Luo, Vigneshwaran Namasivayam, Jennifer Geiss, Salahuddin Mirza, Julie Pelletier, Holger Stephan, Jean Sévigny, Christa E. Müller, The Analyst, 2018, 10.1039/C8AN01108G

Expanding the Alkaline Phosphatase Inhibition, Cytotoxic and Proapoptotic Profile of Biscoumarin‐Iminothiazole and Coumarin‐Triazolothiadiazine Conjugates, Jamshed Iqbal, Syeda Abida Ejaz, Aliya Ibrar, Muhammad Ihtisham Umar, Joanna Lecka, Jean Sévigny, Aamer Saeed, ChemistrySelect, 2018, 10.1002/slct.201801863

Distinct roles of ecto-nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) in liver regeneration and fibrosis, Linda Feldbrügge, Z. Gordon Jiang, Eva Csizmadia, Shuji Mitsuhashi, Stephanie Tran, Eric U. Yee, Sonja Rothweiler, Kahini A. Vaid, Jean Sévigny, Moritz Schmelzle, Yury V. Popov, Simon C. Robson, Purinergic Signalling, 2017, 10.1007/s11302-017-9590-3

Down-regulation of NTPDase2 and ADP-sensitive P2 Purinoceptors Correlate with Severity of Symptoms during Experimental Autoimmune Encephalomyelitis, Marija Jakovljevic, Irena Lavrnja, Iva Bozic, Danijela Savic, Ivana Bjelobaba, Sanja Pekovic, Jean Sévigny, Nadezda Nedeljkovic, Danijela Laketa, Frontiers in Cellular Neuroscience, 2017, 10.3389/fncel.2017.00333

Chemoselective synthesis and biological evaluation of arylated 2-(Trifluoromethyl) quinolines as nucleotide pyrophosphatase (NPPs) inhibitors, David Kuhrt, Syeda Abida Ejaz, Saira Afzal, Shafi Ullah Khan, Joanna Lecka, Jean Sévigny, Peter Ehlers, Anke Spannenberg, Jamshed Iqbal, Peter Langer, European Journal of Medicinal Chemistry, 2017, 10.1016/j.ejmech.2017.07.017

Expression of Ecto-nucleoside Triphosphate Diphosphohydrolases-2 and -3 in the Enteric Nervous System Affects Inflammation in Experimental Colitis and Crohn’s Disease, Linda Feldbrügge, Alan C Moss, Eric U Yee, Eva Csizmadia, Shuji Mitsuhashi, Maria Serena Longhi, Bynvant Sandhu, Holger Stephan, Yan Wu, Adam S Cheifetz, Christa E Müller, Jean Sévigny, Simon C Robson, Z Gordon Jiang, Journal of Crohn's and Colitis, 2017, 10.1093/ecco-jcc/jjx058

Generation and characterization of polyclonal and monoclonal antibodies to human NTPDase2 including a blocking antibody, Julie Pelletier, Hervé Agonsanou, Ninotchska Delvalle, Michel Fausther, Mabrouka Salem, Brian Gulbransen, Jean Sévigny, Purinergic Signalling, 2017, 10.1007/s11302-017-9561-8

Generation and Characterization of Specific Antibodies to the Murine and Human Ectonucleotidase NTPDase8, Julie Pelletier, Mabrouka Salem, Joanna Lecka, Michel Fausther, François Bigonnesse, Jean Sévigny, Frontiers in Pharmacology, 2017, 10.3389/fphar.2017.00115

The expression of NTPDase1 and -2 of Leishmania infantum chagasi in bacterial and mammalian cells: Comparative expression, refolding and nucleotidase characterization, M.S. Bastos, A. Tremblay, J.M. Agripino, I.L.A. Rabelo, L.P. Barreto, J. Pelletier, J. Lecka, A. Silva-Júnior, G.C. Bressan, M.R. Almeida, J. Sévigny, J.L.R. Fietto, Protein Expression and Purification, 2017, 10.1016/j.pep.2016.11.004

Synthesis, characterization and biological evaluation of novel chalcone sulfonamide hybrids as potent intestinal alkaline phosphatase inhibitors, Syeda Abida Ejaz, Aamer Saeed, Muhammad Nasir Siddique, Zaib un Nisa, Samiullah Khan, Joanna Lecka, Jean Sévigny, Jamshed Iqbal, Bioorganic Chemistry, 2017, 10.1016/j.bioorg.2017.01.003

Characterization of ecto-nucleotidases in human oviducts with an improved approach simultaneously identifying protein expression and in situ enzyme activity, María Lina Villamonte, Benjamín Torrejón-Escribano, Aitor Rodríguez-Martínez, Carla Trapero, August Vidal, Inmaculada Gómez de Aranda, Jean Sévigny, Xavier Matías-Guiu, Mireia Martín-Satué, Histochemistry and Cell Biology, 2017, 10.1007/s00418-017-1627-8

Domino Reactions of Chromone-3-carboxylic Acids with Aminoheterocycles: Synthesis of Heteroannulated Pyrido[2,3-c]coumarins and their Optical and Biological Activity, Mariia Miliutina, Julia Janke, Elena Chirkina, Sidra Hassan, Syeda Abida Ejaz, Shafi Ullah Khan, Jamshed Iqbal, Aleksej Friedrich, Stefan Lochbrunner, Anton Ivanov, Alexander Villinger, Joanna Lecka, Jean Sévigny, Peter Langer, European Journal of Organic Chemistry, 2017, 10.1002/ejoc.201701276

Loss of vascular expression of nucleoside triphosphate diphosphohydrolase-1/CD39 in hypertension, Charlotte Roy, Julie Tabiasco, Antoine Caillon, Yves Delneste, Jean Merot, Julie Favre, Anne Laure Guihot, Ludovic Martin, Daniele C. Nascimento, Bernhard Ryffel, Simon C. Robson, Jean Sévigny, Daniel Henrion, Gilles Kauffenstein, Purinergic Signalling, 2017, 10.1007/s11302-017-9597-9

E-NTPDase Family, Jean Sévigny, Encyclopedia of Signaling Molecules, 2016, 10.1007/978-1-4614-6438-9_197-1

Isonicotinohydrazones as inhibitors of alkaline phosphatase and ecto-5′-nucleotidase, Pervaiz Ali Channar, Syed Jawad Ali Shah, Sidra Hassan, Zaib un Nisa, Joanna Lecka, Jean Sévigny, Jürgen Bajorath, Aamer Saeed, Jamshed Iqbal, Chemical Biology & Drug Design, 2016, 10.1111/cbdd.12861

Adenosine A2A receptor and ecto-5′-nucleotidase/CD73 are upregulated in hippocampal astrocytes of human patients with mesial temporal lobe epilepsy (MTLE), Aurora R. Barros-Barbosa, Fátima Ferreirinha, Ângela Oliveira, Marina Mendes, M. Graça Lobo, Agostinho Santos, Rui Rangel, Julie Pelletier, Jean Sévigny, J. Miguel Cordeiro, Paulo Correia-de-Sá, Purinergic Signalling, 2016, 10.1007/s11302-016-9535-2

Regional and sex-related differences in modulating effects of female sex steroids on ecto-5′-nucleotidase expression in the rat cerebral cortex and hippocampus, Nataša Mitrović, Ivana Guševac, Dunja Drakulić, Miloš Stanojlović, Jelena Zlatković, Jean Sévigny, Anica Horvat, Nadežda Nedeljković, Ivana Grković, General and Comparative Endocrinology, 2016, 10.1016/j.ygcen.2016.06.018

17β-Estradiol upregulates ecto-5′-nucleotidase (CD73) in hippocampal synaptosomes of female rats through action mediated by estrogen receptor-α and -β, N. Mitrović, M. Zarić, D. Drakulić, J. Martinović, M. Stanojlović, J. Sévigny, A. Horvat, N. Nedeljković, I. Grković, Neuroscience, 2016, 10.1016/j.neuroscience.2016.03.022

2-Alkoxy-3-(sulfonylarylaminomethylene)-chroman-4-ones as potent and selective inhibitors of ectonucleotidases, Mariya al-Rashida, Gazala Batool, Almas Sattar, Syeda Abida Ejaz, Samiullah Khan, Joanna Lecka, Jean Sévigny, Abdul Hameed, Jamshed Iqbal, European Journal of Medicinal Chemistry, 2016, 10.1016/j.ejmech.2016.02.073

Characterization of hepatic stellate cells, portal fibroblasts, and mesothelial cells in normal and fibrotic livers, Ingrid Lua, Yuchang Li, Jessica A. Zagory, Kasper S. Wang, Samuel W. French, Jean Sévigny, Kinji Asahina, Journal of Hepatology, 2016, 10.1016/j.jhep.2016.01.010

Methotrexate up-regulates ecto-5′-nucleotidase/CD73 and reduces the frequency of T lymphocytes in the glioblastoma microenvironment, Fabrício Figueiró, Catiúscia P. de Oliveira, Letícia S. Bergamin, Liliana Rockenbach, Franciane B. Mendes, Elisa Helena F. Jandrey, Cesar Eduardo J. Moritz, Letícia F. Pettenuzzo, Jean Sévigny, Silvia S. Guterres, Adriana R. Pohlmann, Ana Maria O. Battastini, Purinergic Signalling, 2016, 10.1007/s11302-016-9505-8

17β-Estradiol-Induced Synaptic Rearrangements Are Accompanied by Altered Ectonucleotidase Activities in Male Rat Hippocampal Synaptosomes, Nataša Mitrović, Marina Zarić, Dunja Drakulić, Jelena Martinović, Jean Sévigny, Miloš Stanojlović, Nadežda Nedeljković, Ivana Grković, Journal of Molecular Neuroscience, 2016, 10.1007/s12031-016-0877-6

3-(5-(Benzylideneamino)thiazol-3-yl)-2H-chromen-2-ones: a new class of alkaline phosphatase and ecto-5′-nucleotidase inhibitors, Aamer Saeed, Syeda Abida Ejaz, Muddasar Shehzad, Sidra Hassan, Mariya al-Rashida, Joanna Lecka, Jean Sévigny, Jamshed Iqbal, RSC Advances, 2016, 10.1039/c5ra24684a

New one-pot synthesis of N-fused isoquinoline derivatives by palladium-catalyzed C–H arylation: potent inhibitors of nucleotide pyrophosphatase-1 and -3, Elina Ausekle, Syeda Abida Ejaz, Shafi Ullah Khan, Peter Ehlers, Alexander Villinger, Joanna Lecka, Jean Sévigny, Jamshed Iqbal, Peter Langer, Organic & Biomolecular Chemistry, 2016, 10.1039/c6ob02236g

Synthesis of 2-arylated thiadiazolopyrimidones by Suzuki–Miyaura cross-coupling: a new class of nucleotide pyrophosphatase (NPPs) inhibitors, Behzad Jafari, Nazym Yelibayeva, Meirambek Ospanov, Syeda Abida Ejaz, Saira Afzal, Shafi Ullah Khan, Zharylkasyn A. Abilov, Mirgul Z. Turmukhanova, Sergey N. Kalugin, Sayfidin Safarov, Joanna Lecka, Jean Sévigny, Qamar Rahman, Peter Ehlers, Jamshed Iqbal, Peter Langer, RSC Advances, 2016, 10.1039/c6ra22750c

Ecto-5’-Nucleotidase Overexpression Reduces Tumor Growth in a Xenograph Medulloblastoma Model, Angélica R. Cappellari, Micheli M. Pillat, Hellio D. N. Souza, Fabrícia Dietrich, Francine H. Oliveira, Fabrício Figueiró, Ana L. Abujamra, Rafael Roesler, Joanna Lecka, Jean Sévigny, Ana Maria O. Battastini, Henning Ulrich, PLOS ONE, 2015, 10.1371/journal.pone.0140996

Synthesis and structure–activity relationship of uracil nucleotide derivatives towards the identification of human P2Y 6 receptor antagonists, Diana Meltzer, Ophir Ethan, Guillaume Arguin, Yael Nadel, Ortal Danino, Joanna Lecka, Jean Sévigny, Fernand-Pierre Gendron, Bilha Fischer, Bioorganic & Medicinal Chemistry, 2015, 10.1016/j.bmc.2015.07.004

Rat, Mouse, and Primate Models of Chronic Glaucoma Show Sustained Elevation of Extracellular ATP and Altered Purinergic Signaling in the Posterior Eye, Wennan Lu, HuiLing Hu, Jean Sévigny, B'Ann T. Gabelt, Paul L. Kaufman, Elaine C. Johnson, John C. Morrison, Gulab S. Zode, Val C. Sheffield, Xiulan Zhang, Alan M. Laties, Claire H. Mitchell, Investigative Opthalmology & Visual Science, 2015, 10.1167/iovs.14-15891

Efficient one-pot synthesis of 5-perfluoroalkylpyrazoles by cyclization of hydrazone dianions, Thang Ngoc Ngo, Syeda Abida Ejaz, Tran Quang Hung, Tuan Thanh Dang, Jamshed Iqbal, Joanna Lecka, Jean Sévigny, Peter Langer, Organic & Biomolecular Chemistry, 2015, 10.1039/c5ob01151e

Establishment and characterization of rat portal myofibroblast cell lines, Fausther, M., Goree, J.R., Lavoie, É.G., Graham, A.L., Sévigny, J., Dranoff, J.A., PLoS ONE, 2015, 10.1371/journal.pone.0121161

Extracellular ATP Selectively Upregulates Ecto-Nucleoside Triphosphate Diphosphohydrolase 2 and Ecto-5′-Nucleotidase by Rat Cortical Astrocytes In Vitro, Brisevac, D., Adzic, M., Laketa, D., Parabucki, A., Milosevic, M., Lavrnja, I., Bjelobaba, I., Sévigny, J., Kipp, M., Nedeljkovic, N., Journal of Molecular Neuroscience, 2015, 10.1007/s12031-015-0601-y

Fluorescence polarization immunoassays for monitoring nucleoside triphosphate diphosphohydrolase (NTPDase) activity, Fiene, A., Baqi, Y., Lecka, J., Sévigny, J., Müller, C.E., Analyst, 2015, 10.1039/c4an01694g

Influence of the diversified structural variations at the imine functionality of 4-bromophenylacetic acid derived hydrazones on alkaline phosphatase inhibition: synthesis and molecular modelling studies, Imtiaz Khan, Aliya Ibrar, Syeda Abida Ejaz, Shafi Ullah Khan, Syed Jawad Ali Shah, Shahid Hameed, Jim Simpson, Joanna Lecka, Jean Sévigny, Jamshed Iqbal, RSC Advances, 2015, 10.1039/c5ra14836g

Investigation of quinoline-4-carboxylic acid as a highly potent scaffold for the development of alkaline phosphatase inhibitors: synthesis, SAR analysis and molecular modelling studies, Imtiaz Khan, Syed Jawad Ali Shah, Syeda Abida Ejaz, Aliya Ibrar, Shahid Hameed, Joanna Lecka, Jose Luis Millán, Jean Sévigny, Jamshed Iqbal, RSC Advances, 2015, 10.1039/c5ra12455g

Involvement of purinergic system in the release of cytokines by macrophages exposed to glioma-conditioned medium, Bergamin, L.S., Braganhol, E., Figueirõ, F., Casali, E.A., Zanin, R.F., Sévigny, J., Battastini, A.M.O., Journal of Cellular Biochemistry, 2015, 10.1002/jcb.25018

Nucleotide receptors control IL-8/CXCL8 and MCP-1/CCL2 secretions as well as proliferation in human glioma cells, Braganhol, E., Kukulski, F., Lévesque, S.A., Fausther, M., Lavoie, E.G., Zanotto-Filho, A., Bergamin, L.S., Pelletier, J., Bahrami, F., Yebdri, F.B., Fonseca Moreira, J.C., Battastini, A.M.O., Sévigny, J., Biochimica et Biophysica Acta - Molecular Basis of Disease, 2015, s1016/j.bbadis.2014.10.014

Polyoxometalates - Potent and selective ecto-nucleotidase inhibitors, Lee, S.-Y., Fiene, A., Li, W., Hanck, T., Brylev, K.A., Fedorov, V.E., Lecka, J., Haider, A., Pietzsch, H.-J., Zimmermann, H., Sévigny, J., Kortz, U., Stephan, H., Müller, C.E., Biochemical Pharmacology, 2015, 10.1016/j.bcp.2014.11.002

Purinergic Signalling in Immune System Regulation in Health and Disease, Jean Sévigny, Mireia Martín-Satué, Jesús Pintor, Mediators of Inflammation, 2015, 10.1155/2015/106863

Quinazoline-4-piperidine sulfamides are specific inhibitors of human NPP1 and prevent pathological mineralization of valve interstitial cells, Shayhidin, E.E., Forcellini, E., Boulanger, M.-C., Mahmut, A., Dautrey, S., Barbeau, X., Lagüe, P., Sévigny, J., Paquin, J.-F., Mathieu, P., British Journal of Pharmacology, 2015, 10.1111/bph.13204

Rat submandibular glands secrete nanovesicles with NTPDase and 5′-nucleotidase activities, González, D.A., Egido, P., Balcarcel, N.B., Hattab, C., Barbieri van Haaster, M.M., Pelletier, J., Sévigny, J., Ostuni, M.A., Purinergic Signalling, 2015, 10.1007/s11302-014-9437-0

Synthesis, characterization and biological evaluation of N-(2,3-dimethyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-4-yl)benzamides, Aamer Saeed, Syeda Abida Ejaz, Asma Khurshid, Sidra Hassan, Mariya al-Rashida, Muhammad Latif, Joanna Lecka, Jean Sévigny, Jamshed Iqbal, RSC Advances, 2015, 10.1039/c5ra17568b

2-Hexylthio-β,γ-CH2-ATP is an effective and selective NTPDase2 inhibitor, Gillerman, I., Lecka, J., Simhaev, L., Munkonda, M.N., Fausther, M., Martín-Satué, M., Senderowitz, H., Sévigny, J., Fischer, B., Journal of Medicinal Chemistry, 2014, 10.1021/jm401933c

Ca2+ responses in enteric glia are mediated by connexin-43 hemichannels and modulate colonic transit in mice, McClain, J.L., Grubišić, V., Fried, D., Gomez-Suarez, R.A., Leinninger, G.M., Sévigny, J., Parpura, V., Gulbransen, B.D., Gastroenterology, 2014, 10.1053/j.gastro.2013.10.061

CD39 may impact clopidrogrel pharmacodynamics, , Austin J. Clin. Immunol., 2014

Feed-Forward Inhibition of CD73 and Upregulation of Adenosine Deaminase Contribute to the Loss of Adenosine Neuromodulation in Postinflammatory Ileitis, Cátia Vieira, Maria Teresa Magalhães-Cardoso, Fátima Ferreirinha, Isabel Silva, Ana Sofia Dias, Julie Pelletier, Jean Sévigny, Paulo Correia-de-Sá, Mediators of Inflammation, 2014, 10.1155/2014/254640

Highly potent and selective ectonucleotide pyrophosphatase/ phosphodiesterase i inhibitors based on an adenosine 5′-(α or γ)-Thio-(α,β- or β,γ)-methylenetriphosphate scaffold, Nadel, Y., Lecka, J., Gilad, Y., Ben-David, G., Förster, D., Reiser, G., Kenigsberg, S., Camden, J., Weisman, G.A., Senderowitz, H., Sévigny, J., Fischer, B., Journal of Medicinal Chemistry, 2014, 10.1021/jm500196c

Impact of ectonucleotidases in autonomic nervous functions, Cardoso, A.M., Schetinger, M.R.C., Correia-de-Sá, P., Sévigny, J., Autonomic Neuroscience: Basic and Clinical, 2014, 10.1016/j.autneu.2015.04.014

Longitudinal analysis of calorie restriction on rat taste bud morphology and expression of sweet taste modulators, Cai, H., Daimon, C.M., Cong, W.-N., Wang, R., Chirdon, P., De Cabo, R., Sévigny, J., Maudsley, S., Martin, B., Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 2014, 10.1093/gerona/glt129

NTPDase3 and ecto-5'-nucleotidase/CD73 are differentially expressed during mouse bladder cancer progression, Rockenbach, L., Braganhol, E., Dietrich, F., Figueiró, F., Pugliese, M., Edelweiss, M.I., Morrone, F.B., Sévigny, J., Battastini, A.M., Purinergic signalling, 2014, 10.1007/s11302-014-9405-8

Nucleoside triphosphate diphosphohydrolase-1 ectonucleotidase is required for normal vas deferens contraction and male fertility through maintaining P2X1 receptor function, Kauffenstein, G., Pelletier, J., Lavoie, E.G., Kukulski, F., Martiń-Satué, M., Dufresne, S.S., Frenette, J., Fürstenau, C.R., Sereda, M.J., Toutain, B., Henrion, D., Sullivan, R., Vial, C., Sévigny, J., Journal of Biological Chemistry, 2014, 10.1074/jbc.M114.604082

Purine-metabolizing ectoenzymes control IL-8 production in human colon HT-29 cells, Bahrami, F., Kukulski, F., Lecka, J., Tremblay, A., Pelletier, J., Rockenbach, L., Sévigny, J., Mediators of Inflammation, 2014, 10.1155/2014/879895

Ticlopidine in Its Prodrug Form Is a Selective Inhibitor of Human NTPDase1, Joanna Lecka, Michel Fausther, Beat Künzli, Jean Sévigny, Mediators of Inflammation, 2014, 10.1155/2014/547480

Dual role of P2Y6 receptors in the human urinary bladder: On the role of ATP released from the urothelium, Isabel Silva, M. Alexandrina Timóteo, Joana Correia, Fátima Ferreirinha, Miguel Silva-Ramos, Jean Sévigny, Paulo Correia-de-Sá, Autonomic Neuroscience, 2013, 10.1016/j.autneu.2013.08.021

8-BuS-ATP derivatives as specific NTPDase1 inhibitors, Lecka, J., Gillerman, I., Fausther, M., Salem, M., Munkonda, M.N., Brosseau, J.-P., Cadot, C., Martín-Satué, M., D'Orléans-Juste, P., Rousseau, E., Poirier, D., Künzli, B., Fischer, B., Sévigny, J., British Journal of Pharmacology, 2013, 10.1111/bph.12135

Altered Lipid and Salt Taste Responsivity in Ghrelin and GOAT Null Mice, Cai, H., Cong, W.-N., Daimon, C.M., Wang, R., Tschöp, M.H., Sévigny, J., Martin, B., Maudsley, S., PLoS ONE, 2013, 10.1371/journal.pone.0076553

Attenuated allergic airway inflammation in Cd39 null mice, Idzko, M., Ayata, C.K., Müller, T., Dürk, T., Grimm, M., Baudiß, K., Vieira, R.P., Cicko, S., Boehlke, C., Zech, A., Sorichter, S., Pelletier, J., Sévigny, J., Robson, S.C., Allergy: European Journal of Allergy and Clinical Immunology, 2013, 10.1111/all.12119

Ecto-5′- nucleotidase (CD73)-mediated formation of adenosine is critical for the striatal adenosine A2A receptor functions, Augusto, E., Matos, M., Sévigny, J., El-Tayeb, A., Bynoe, M.S., Müller, C.E., Cunha, R.A., Chen, J.-F., Journal of Neuroscience, 2013, 10.1523/JNEUROSCI.5817-12.2013

Ecto-nucleotidases distribution in human cyclic and postmenopausic endometrium, Aliagas, E., Vidal, A., Torrejón-Escribano, B., Taco, M.R., Ponce, J., Gómez de Aranda, I., Sévigny, J., Condom, E., Martín-Satué, M., Purinergic Signalling, 2013, 10.1007/s11302-012-9345-0

Histamine induces ATP release from human subcutaneous fibroblasts, via pannexin-1 hemichannels, leading to Ca2+ mobilization and cell proliferation, Pinheiro, A.R., Paramos-De-carvalho, D., Certal, M., Costa, M.A., Costa, C., Magalhães-Cardoso, M.T., Ferreirinha, F., Sévigny, J., Correia-De-Sá, P., Journal of Biological Chemistry, 2013, 10.1074/jbc.M113.460865

Homocysteine modifies extracellular ATP availability in macrophages, Zanin, R.F., Bergamin, L.S., Braganhol, E., Sévigny, J., de Souza Wyse, A.T., Battastini, A.M.O., Toxicology in Vitro, 2013, 10.1016/j.tiv.2013.09.001

Identification of novel chromone based sulfonamides as highly potent and selective inhibitors of alkaline phosphatases, Al-Rashida, M., Raza, R., Abbas, G., Shah, M.S., Kostakis, G.E., Lecka, J., Sev́igny, J., Muddassar, M., Papatriantafyllopoulou, C., Iqbal, J., European Journal of Medicinal Chemistry, 2013, 10.1016/j.ejmech.2013.06.015

Identification of sulfonic acids as efficient ecto-5′-nucleotidase inhibitors, Iqbal, J., Saeed, A., Raza, R., Matin, A., Hameed, A., Furtmann, N., Lecka, J., Sévigny, J., Bajorath, J., European Journal of Medicinal Chemistry, 2013, 10.1016/j.ejmech.2013.10.053

Nonhydrolyzable ATP analogues as selective inhibitors of human NPP1: A combined computational/experimental study, Lecka, J., Ben-David, G., Simhaev, L., Eliahu, S., Oscar, J., Luyindula, P., Pelletier, J., Fischer, B., Senderowitz, H., Sévigny, J., Journal of Medicinal Chemistry, 2013, 10.1021/jm400918s

Nucleoside-(5′→P) methylenebisphosphonodithioate analogues: Synthesis and chemical properties, Meltzer, D., Nadel, Y., Lecka, J., Amir, A., Sévigny, J., Fischer, B., Journal of Organic Chemistry, 2013, 10.1021/jo400931n

P2Y(6)-induced release of ATP from the urothelium exerts a dual role in the human urinary bladder, Silva, I., Correia, J., Ferreirinha, F., Silva-Ramos, M., Sevigny, J., Correia-de-Sa, P., The FEBS Journal, 2013

Reduced striatal ecto-nucleotidase activity in schizophrenia patients supports the "adenosine hypothesis", Aliagas, E., Villar-Menéndez, I., Sévigny, J., Roca, M., Romeu, M., Ferrer, I., Martín-Satué, M., Barrachina, M., Purinergic Signalling, 2013, 10.1007/s11302-013-9370-7

Regulatory T Cells Negatively Affect IL-2 Production of Effector T Cells through CD39/Adenosine Pathway in HIV Infection, Jenabian, M.-A., Seddiki, N., Yatim, A., Carriere, M., Hulin, A., Younas, M., Ghadimi, E., Kök, A., Routy, J.-P., Tremblay, A., Sévigny, J., Lelievre, J.-D., Levy, Y., PLoS Pathogens, 2013, 10.1371/journal.ppat.1003319

A highly sensitive capillary electrophoresis method using p-nitrophenyl 5'-thymidine monophosphate as a substrate for the monitoring of nucleotide pyrophosphatase/phosphodiesterase activities, Lee, S.-Y., Lévesque, S.A., Sévigny, J., Müller, C.E., Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2012, 10.1016/j.jchromb.2012.10.044

Coexpression of ecto-5'-nucleotidase/CD73 with specific NTPDases differentially regulates adenosine formation in the rat liver, Fausther, M., Lecka, J., Soliman, E., Kauffenstein, G., Pelletier, J., Sheung, N., Dranoff, J.A., Sévigny, J., American Journal of Physiology - Gastrointestinal and Liver Physiology, 2012, 10.1152/ajpgi.00165.2011

Differential macrophage activation alters the expression profile of NTPDase and Ecto-5′-nucleotidase, Zanin, R.F., Braganhol, E., Bergamin, L.S., Campesato, L.F.I., Filho, A.Z., Moreira, J.C.F., Morrone, F.B., Sévigny, J., Schetinger, M.R.C., de Souza Wyse, A.T., Battastini, A.M.O., PLoS ONE, 2012, 10.1371/journal.pone.0031205

E-NTPDase Family, Toru Miki, Randa Hilal-Dandan, Laurence L. Brunton, Jean Sévigny, Kwok-On Lai, Nancy Y. Ip, Renping Zhou, Francesca Milanesi, Niels Volkmann, Giorgio Scita, Dorit Hanein, Jacques Pouysségur, Philippe Lenormand, Sonia Klinger, Sylvain Meloche, Karin Dahlman-Wright, Chunyan Zhao, Encyclopedia of Signaling Molecules, 2012, 10.1007/978-1-4419-0461-4_197

Expression of ecto-ATPase NTPDase2 in human dental pulp, Liu, X., Yu, L., Wang, Q., Pelletier, J., Fausther, M., Sévigny, J., Malmström, H.S., Dirksen, R.T., Ren, Y.-F., Journal of Dental Research, 2012, 10.1177/0022034511431582

Identification of small molecule sulfonic acids as ecto-5'-nucleotidase inhibitors, Raza, R., Saeed, A., Lecka, J., Sévigny, J., Iqbal, J., Medicinal Chemistry, 2012, 10.2174/1573406411208061133

Localization and role of ecto-5'-nucleotidase (CD73) in the basal ganglia - Relation to adenosine A2A receptors, Augusto, E., Chen, J. -F., Cunha, R. A., Matos, M., Sevigny, J., Society for Neuroscience Abstract Viewer and Itinerary Planner, 2012

Overexpression of NTPDase2 in gliomas promotes systemic inflammation and pulmonary injury, Braganhol, E., Zanin, R.F., Bernardi, A., Bergamin, L.S., Cappellari, A.R., Campesato, L.F., Morrone, F.B., Campos, M.M., Calixto, J.B., Edelweiss, M.I.A., Wink, M.R., Sévigny, J., Robson, S.C., Battastini, A.M.O., Purinergic Signalling, 2012, 10.1007/s11302-011-9276-1

Role of ecto-NTPDases on UDP-sensitive P2Y 6 receptor activation during osteogenic differentiation of primary bone marrow stromal cells from postmenopausal women, Noronha-Matos, J.B., Costa, M.A., Magalhães-Cardoso, M.T., Ferreirinha, F., Pelletier, J., Freitas, R., Neves, J.M., Sévigny, J., Correia-de-Sá, P., Journal of Cellular Physiology, 2012, 10.1002/jcp.23014

UDP-SENSITIVE P2Y6 RECEPTORS PLAY A DUAL ROLE IN THE HUMAN URINARY BLADDER INDIRECTLY VIA THE RELEASE OF ATP FROM UROTHELIUM, Carneiro, I, Correia, J., Correia-de-Sa, P., Ferreirinha, F., Monteiro, D., Sevigny, J., Silva, I, Silva, N., Silva-Ramos, M., Timoteo, M. A., Vieira, C., Neurourology and Urodynamics, 2012

Distribution of ecto-nucleotidases in mouse sensory circuits suggests roles for nucleoside triphosphate diphosphohydrolase-3 in nociception and mechanoreception, Vongtau, H.O., Lavoie, E.G., Sévigny, J., Molliver, D.C., Neuroscience, 2011, 10.1016/j.neuroscience.2011.07.044

Ectonucleotidases in the digestive system: Focus on NTPDase3 localization, Lavoie, E.G., Gulbransen, B.D., Martín-Satué, M., Aliagas, E., Sharkey, K.A., Sévigny, J., American Journal of Physiology - Gastrointestinal and Liver Physiology, 2011, 10.1152/ajpgi.00207.2010

Extracellular nucleosides and nucleotides regulate liver functions via a complex system of membrane proteins, Fausther, M., Sévigny, J., Comptes Rendus - Biologies, 2011, 10.1016/j.crvi.2010.12.005

Identification of potent and selective human ecto-nucleotide pyrophosphatase/phosphodiesterase-3 (hNPP3) inhibitors, Raza, R., Akhtar, T., Hameed, S., Lecka, J., Iqbal, J., Sévigny, J., Open Enzyme Inhibition Journal, 2011, 10.2174/1874940201104010017

Impact of Ectoenzymes on P2 and P1 Receptor Signaling, Kukulski, F., Lévesque, S.A., Sévigny, J., Advances in Pharmacology, 2011, 10.1016/B978-0-12-385526-8.00009-6

Light, Adenosine Transporters, And Ecto-nucleotidases Contribute To Adenosine Levels In The Outer Retina, Dale, Nicholas, Sevigny, Jean, Stella, Salvatore L., Jr., ARVO Annual Meeting Abstract Search and Program Planner, 2011

NTPDase1 controls IL-8 production by human neutrophils, Kukulski, F., Bahrami, F., Ben Yebdri, F., Lecka, J., Martín-Satué, M., Lévesque, S.A., Sévigny, J., Journal of Immunology, 2011, 10.4049/jimmunol.1002680

NTPDase3 is the principal ectonucleotidase in both nociceptors and low threshold mechanoreceptors, Lavoie, E. G., Molliver, D. C., Sevigny, J., Vongtau, H. O., Society for Neuroscience Abstract Viewer and Itinerary Planner, 2011

Nucleoside triphosphate diphosphohydrolases role in the pathophysiology of cognitive impairment induced by seizure in early age, Cognato, G.P., Vuaden, F.C., Savio, L.E.B., Bellaver, B., Casali, E., Bogo, M.R., Souza, D.O.G., Sévigny, J., Bonan, C.D., Neuroscience, 2011, 10.1016/j.neuroscience.2011.01.065

2-MeS-β,γ-CCl2-ATP is a potent agent for reducing intraocular pressure, Eliahu, S., Martín-Gil, A., Perez De Lara, M.J., Pintor, J., Camden, J., Weisman, G.A., Lecka, J., Sévigny, J., Fischer, B., Journal of Medicinal Chemistry, 2010, 10.1021/jm100030u

Changes in ecto-nucleotidases in murine and human endometria along the female cycle, Aliagas Marin, Elisabet, Lavoie, E. G., Martin Satue, Mireia, Ponce, J., Sevigny, J., Taco-Sanchez, M. R., Torrejon-Escribano, B., Vidal, A., Purinergic Signalling, 2010

Changes in expression and activity levels of ecto-5′-nucleotidase/ CD73 along the mouse female estrous cycle, Aliagas, E., Torrejón-Escribano, B., Lavoie, E.G., De Aranda, I.G., Sévigny, J., Solsona, C., Martín-Satué, M., Acta Physiologica, 2010, 10.1111/j.1748-1716.2010.02095.x

Cystic fibrosis remodels the regulation of purinergic signaling by NTPDase1 (CD39) and NTPDase3, Fausther, M., Pelletier, J., Ribeiro, C.M., Sévigny, J., Picher, M., American Journal of Physiology - Lung Cellular and Molecular Physiology, 2010, 10.1152/ajplung.00019.2010

Diadenosine 5',5'-(Boranated)polyphosphonate analogues as selective nucleotide pyrophosphatase/phosphodiesterase inhibitors ⊥, Eliahu, S., Lecka, J., Reiser, G., Haas, M., Bigonnesse, F., Lévesque, S.A., Pelletier, J., Sévigny, J., Fischer, B., Journal of Medicinal Chemistry, 2010, 10.1021/jm100597c

Endothelial P2Y2 receptor regulates LPS-induced neutrophil transendothelial migration in vitro, Kukulski, F., Yebdri, F.B., Bahrami, F., Fausther, M., Tremblay, A., Sévigny, J., Molecular Immunology, 2010, 10.1016/j.molimm.2009.11.020

Epitope mapping in cell surface proteins by site-directed masking: Defining the structural elements of NTPDase3 inhibition by a monoclonal antibody, Ivanenkov, V.V., Crawford, P.A., Toyama, A., Sévigny, J., Kirley, T.L., Protein Engineering, Design and Selection, 2010, 10.1093/protein/gzq027

Erratum: Changes in expression and activity levels of ecto-5'-nucleotidase/ CD73 along the mouse female estrous cycle (Acta Physiologica (2010) 199 (191-197)), Aliagas, E., Torrejón-Escribano, B., Lavoie, E.G., Gómez De Aranda, I., Sévigny, J., Solsona, C., Martín-Satué, M., Acta Physiologica, 2010, 10.1111/j.1748-1716.2010.02178.x

Essential role of P2Y6 receptor in vascular contraction-lessons from P2Y6 knockout mice, Henrion, Daniel, Kauffenstein, Gilles, Loufrani, Laurent, Robaye, Bernard, Sevigny, Jean, Purinergic Signalling, 2010

Extracellular nucleotides and ectonucleotidases control IL-8 production in human colon HT-29 cells, Bahrami, Fariborz, Kukulski, Filp, Lecka, Joanna, Pelletier, Julie, Sevigny, Jean, Purinergic Signalling, 2010

Generation and characterization of a monoclonal antibody as the first specific inhibitor of human NTPDase3, Fausther, M., Ivanenkov, V. V., Kirley, T. L., Kuenzli, B., Munkonda, M. N., Pelletier, J., Sevigny, J., Tremblay, A., Febs Journal, 2010

Ghrelin is produced in taste cells and ghrelin receptor null mice show reduced taste responsivity to salty (NaCl) and sour (Citric Acid) tastants, Shin, Y.-K., Martin, B., Kim, W., White, C.M., Ji, S., Sun, Y., Smith, R.G., Sévigny, J., Tschöp, M.H., Maudsley, S., Egan, J.M., PLoS ONE, 2010, 10.1371/journal.pone.0012729

High expression and activity of ecto-5'-nucleotidase/CD73 in the male murine reproductive tract, Martín-Satué, M., Lavoie, E.G., Fausther, M., Lecka, J., Aliagas, E., Kukulski, F., Sévigny, J., Histochemistry and Cell Biology, 2010, 10.1007/s00418-010-0704-z

Identification of the ectonucleotidases expressed in mouse, rat, and human Langerhans islets: Potential role of NTPDase3 in insulin secretion, Lavoie, E.G., Fausther, M., Kauffenstein, G., Kukulski, F., Künzli, B.M., Friess, H., Sévigny, J., American Journal of Physiology - Endocrinology and Metabolism, 2010, 10.1152/ajpendo.00126.2010

Inhibition of vascular ectonucleotidase activities by the pro-drugs ticlopidine and clopidogrel favours platelet aggregation, Lecka, J., Rana, M.S., Sévigny, J., British Journal of Pharmacology, 2010, 10.1111/j.1476-5381.2010.00951.x

NTPDase1 (CD39) controls nucleotide dependent vasomotion in mouse, D'Orleans-Juste, Pedro, Drouin, Annick, Fuerstenau, Cristina Ribas, Kauffenstein, Gilles, Marceau, Francois, Robaye, Bernard, Sevigny, Jean, Thorin, Eric, Thorin-Trescases, Nathalie, Purinergic Signalling, 2010

NTPDase1 (CD39) controls nucleotide-dependent vasoconstriction in mouse, Kauffenstein, G., Drouin, A., Thorin-Trescases, N., Bachelard, H., Robaye, B., D'Orléans-Juste, P., Marceau, F., Thorin, E., Sévigny, J., Cardiovascular Research, 2010, 10.1093/cvr/cvp265

NTPDase1 governs P2X7-dependent functions in murine macrophages, Lévesque, S.A., Kukulski, F., Enjyoji, K., Robson, S.C., Sévigny, J., European Journal of Immunology, 2010, 10.1002/eji.200939741

Opposite deregulations of NTPDase1 (CD39) and NTPDase3 by cystic fibrosis, Fausther, Michel, Pelletier, Julie, Picher, Maryse, Ribeiro, Carla M., Sevigny, Jean, Purinergic Signalling, 2010

ROLE OF NUCLEOTIDES, ECTONUCLEOTIDASES AND P2 RECEPTORS IN VASCULAR CONTRACTION AND MYOGENIC TONE, Drouin, A., Henrion, D., Kauffenstein, G., Loufrani, L., Robaye, B., Sevigny, J., Thorin, E., Hypertension, 2010

The ecto-nucleotidase NTPDase1 differentially regulates P2Y1 and P2Y2 receptor-dependent vasorelaxation, Kauffenstein, G., Fürstenau, C.R., D'Orléans-Juste, P., Sévigny, J., British Journal of Pharmacology, 2010, 10.1111/j.1476-5381.2009.00566.x

The ectonucleotidase NTPDase1 controls IL-8 production by human neutrophils, Kukulski, Filip, Bahrami, Fariborz, Ben Yebdri, Fethia, Lecka, Joanna, Martin-Satue, Mireia, Levesque, Sebstien, Sevigny, Jean, Purinergic Signalling, 2010

The ectonucleotidase NTPDase1 controls IL-8 production by human neutrophils, Bahrami, Fariborz, Ben Yebdri, Fethia, Kukulski, Filip, Lecka, Joanna, Levesque, Sebstien, Martin-Satue, Mireia, Sevigny, Jean, Purinergic Signalling, 2010

The P2 receptor antagonist PPADS abrogates LPS-induced neutrophil migration in the murine air pouch via inhibition of MIP-2 and KC production, Kukulski, F., Yebdri, F.B., Bahrami, F., Lévesque, S.A., Martín-Satué, M., Sévigny, J., Molecular Immunology, 2010, 10.1016/j.molimm.2009.09.037

CD39 deletion exacerbates experimental murine colitis and human polymorphisms increase susceptibility to inflammatory bowel disease, Friedman, D.J., Künzli, B.M., A-Rahim, Y.I., Sevigny, J., Berberat, P.O., Enjyoji, K., Csizmadia, E., Friess, H., Robson, S.C., Proceedings of the National Academy of Sciences of the United States of America, 2009, 10.1073/pnas.0902869106

Characterization of a monoclonal antibody as the first specific inhibitor of human NTP diphosphohydrolase-3: Partial characterization of the inhibitory epitope and potential applications, Munkonda, M.N., Pelletier, J., Ivanenkov, V.V., Fausther, M., Tremblay, A., Künzli, B., Kirley, T.L., Sévigny, J., FEBS Journal, 2009, 10.1111/j.1742-4658.2008.06797.x

Concomitant activation of P2Y2 and P2Y6 receptors on monocytes is required for TLR1/2-induced neutrophil migration by regulating IL-8 secretion, Yebdri, F.B., Kukulski, F., Tremblay, A., Sévigny, J., European Journal of Immunology, 2009, 10.1002/eji.200939347

Ectonucleotidases in the kidney, Shirley, D.G., Vekaria, R.M., Sévigny, J., Purinergic Signalling, 2009, 10.1007/s11302-009-9152-4

EXPRESSION OF PLASMA MEMBRANE BOUND ECTONUCLEOTIDASES IN THE MALE MURINE REPRODUCTIVE TRACT, Fausther, Michel, Lavoie, Elise, Martin Satue, Mireia, Robson, Simon, Sevigny, Jean, Journal of Andrology, 2009

Extracellular ATP and P2 receptors are required for IL-8 to induce neutrophil migration, Kukulski, F., Ben Yebdri, F., Lecka, J., Kauffenstein, G., Lévesque, S.A., Martín-Satué, M., Sévigny, J., Cytokine, 2009, 10.1016/j.cyto.2009.02.011

Identification of hydrolytically stable and selective P2Y1 receptor agonists, Eliahu, S.E., Camden, J., Lecka, J., Weisman, G.A., Sévigny, J., Gélinas, S., Fischer, B., European Journal of Medicinal Chemistry, 2009, 10.1016/j.ejmech.2008.07.015

Immunocytochemical localization of NTPDases1 and 2 in the neural retina of mouse and zebrafish, Ricatti, M.J., Alfie, L.D., Lavoie, É.G., Sévigny, J., Schwarzbaum, P.J., Faillace, M.P., Synapse, 2009, 10.1002/syn.20605

IS FAILURE TO REGULATE NEUTROPHIL RECRUITMENT IN CYSTIC FIBROSIS CAUSED BY THE LOSS OF AIRWAY NTPDASEI?, Boucher, R. C., Fausther, M., Pelletier, J., Picher, M., Ribeiro, C. M., Sevigny, J., Pediatric Pulmonology, 2009

Localization of plasma membrane bound NTPDases in the murine reproductive tract, Martín-Satué, M., Lavoie, É.G., Pelletier, J., Fausther, M., Csizmadia, E., Guckelberger, O., Robson, S.C., Sévigny, J., Histochemistry and Cell Biology, 2009, 10.1007/s00418-008-0551-3

P2Y2 receptor transcription is increased by NF-κB and stimulates cyclooxygenase-2 expression and PGE2 released by intestinal epithelial cells, Degagné, E., Grbic, D.M., Dupuis, A.-A., Lavoie, E.G., Langlois, C., Jain, N., Weisman, G.A., Sévigny, J., Gendron, F.-P., Journal of Immunology, 2009, 10.4049/jimmunol.0803977

Assignment of ecto-nucleoside triphosphate diphosphohydrolase-1/cd39 expression to microglia and vasculature of the brain, Norbert Braun, Jean Sévigny, Simon C. Robson, Keiichi Enjyoji, Olaf Guckelberger, Klaus Hammer, Francesco Di Virgilio, Herbert Zimmermann, European Journal of Neuroscience, 2008, 10.1111/j.1460-9568.2000.01342.x

A highly sensitive CE-UV method with dynamic coating of silica-fused capillaries for monitoring of nucleotide pyrophosphatase/ phosphodiesterase reactions, Iqbal, J., Lévesque, S.A., Sévigny, J., Müller, C.E., Electrophoresis, 2008, 10.1002/elps.200800013

Co-expression of ecto-5 '-nucleotidase/CD73 with NTPDases in the liver distinctly regulates adenosine formation, Fausther, Michel, Lecka, Joanna, Sevigny, Jean, Zimmermann, Herbert, Purinergic Signalling, 2008

Generation and characterization of a monoclonal antibody as the first specific inhibitor of human NTPDase3, Fausther, Michel, Ivanenkov, Vasily, Kirley, Terence, Kuenzli, Beat, Munkonda, Mercedes, Pelletier, Julie, Sevigny, Jean, Tremblay, Alain, Purinergic Signalling, 2008

Hydrolytically stable and selective P2Y(1/6) receptor agonists, Camden, Jean, Eliahu, Shay E., Fischer, Bilha, Lecka, Joanna, Nahum, Vicky, Reiser, Georg, Sevigny, Jean, Weisman, Gary, Yelovitch, Shir, Purinergic Signalling, 2008

Identification of hydrolytically stable and selective P2Y(1) receptor agonists, Camden, Jean, Elyahu, Shay, Fischer, Bilha, Gelinas, Sylvie, Lecka, Joanna, Sevigny, Jean, Weisman, Gary A., Purinergic Signalling, 2008

IL-6 downregulates transcription of NTPDase2 via specific promoter elements, Yu, J., Lavoie, É.G., Sheung, N., Tremblay, J.J., Sévigny, J., Dranoff, J.A., American Journal of Physiology - Gastrointestinal and Liver Physiology, 2008, 10.1152/ajpgi.00208.2007

Intestinal inflammation up-regulates the expression of the G protein-coupled receptor P2Y2 at the transcriptional level, Degagne, Emilie, Dupuis, Andree-Anne, Gendron, Fernand-Pierre, Grbic, Djordje, Lavoie, Elyse, Sevigny, Jean, Purinergic Signalling, 2008

Localization of the ecto-NTPDases in the murine reproductive tract, Czismadia, Eva, Fausther, Michel, Guckelberger, Olaf, Lavoie, Elise G., Martin-Satue, Mireia, Pelletier, Julie, Robson, Simon C., Sevigny, Jean, Purinergic Signalling, 2008

Novel and specific inhibitors of ectonucleotidases, Fischer, Bilha, Gillerman, Irina, Lecka, Joanna, Munkonda, Mercedes, Sevigny, Jean, Purinergic Signalling, 2008

NTPDase1 (cd39) regulates extracellular nucleotides-induced vasomotion, Kauffenstein, G., Sevigny, J., European Journal of Clinical Investigation, 2008

NTPDASE1 modulates P2X7 responses in murine peritoneal macrophages, Kukulski, Filip, Levesque, Sebastien A., Sevigny, Jean, Purinergic Signalling, 2008

Regulation of insulin secretion by NTPDase3, Fausther, Michel, Lavoie, Elise G., Sevigny, Jean, Purinergic Signalling, 2008

Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: Nucleotide mimetics derived from uridine-5′-carboxamide, Brunschweiger, A., Iqbal, J., Umbach, F., Scheiff, A.B., Munkonda, M.N., Sévigny, J., Knowles, A.F., Müller, C.E., Journal of Medicinal Chemistry, 2008, 10.1021/jm800175e

Synthesis and characterization of nucleotide mimetics as inhibitors of ecto-5 '-nucleotidase (CD73) and NTPDase1 (CD39), Brunschweiger, A., Iqbal, J., Lee, S. -Y, Mueller, C. E., Munkonda, M. N., Sevigny, J., Zimmermann, H., Purinergic Signalling, 2008

The candidate sour taste receptor, PKD2L1, Is expressed by type III taste cells in the mouse, Kataoka, S., Yang, R., Ishimaru, Y., Matsunami, H., Sévigny, J., Kinnamon, J.C., Finger, T.E., Chemical Senses, 2008, 10.1093/chemse/bjm083

The endothelial P2Y2 receptor mediates LPS-induced neutrophil transendothelial migration, Ben Yebdri, Fethia, Fausther, Michel, Kukulski, Filip, Sevigny, Jean, Tremblay, Alain, Purinergic Signalling, 2008

Thienopyridines as specific inhibitors of NTPDase1, Fausther, Michel, Lecka, Joanna, Sevigny, Jean, Purinergic Signalling, 2008

Trafficking and intracellular ATPase activity of human ecto-nucleotidase NTPDase3 and the effect of ER-targeted NTPDase3 on protein folding, Ivanenkov, V.V., Sévigny, J., Kirley, T.L., Biochemistry, 2008, 10.1021/bi800402q

NTPDase8, Jean Sevigny, AfCS-Nature Molecule Pages, 2007, 10.1038/mp.a003955.01

Cloning, purification, and identification of the liver canalicular ecto-ATPase as NTPDase8, Fausther, M., Lecka, J., Kukulski, F., Lévesque, S.A., Pelletier, J., Zimmermann, H., Dranoff, J.A., Sévigny, J., American Journal of Physiology - Gastrointestinal and Liver Physiology, 2007, 10.1152/ajpgi.00293.2006

Extracellular nucleotides mediate LPS-induced neutrophil migration in vitro and in vivo, Kukulski, F., Yebdri, F.B., Lefebvre, J., Warny, M., Tessier, P.A., Sévigny, J., Journal of Leukocyte Biology, 2007, 10.1189/jlb.1206758

IL-6 transcriptionally downregulates portal fibroblast Ntpdase2 expression via specific promoter elements, Dranoff, Jonathan A., Lavoie, elise, Sevigny, Jean, Sheung, Nina, Yu, Jin, Gastroenterology, 2007

Inhibition of human and mouse plasma membrane bound NTPDases by P2 receptor antagonists, Munkonda, M.N., Kauffenstein, G., Kukulski, F., Lévesque, S.A., Legendre, C., Pelletier, J., Lavoie, E.G., Lecka, J., Sévigny, J., Biochemical Pharmacology, 2007, 10.1016/j.bcp.2007.07.033

NTPDASE1 (CD39) regulates extracellular nuclecitides-induced vasomotion, Kauffenstein, G., Sevigny, J., Canadian Journal of Cardiology, 2007

Nucleotide signaling in adult neurogenesis, Braun, N., Delic, J., Gampe, K., Grimm, Y., Kettenmann, H., Korf, H. W., Langer, D., Mishra, S. K., Robson, S. C., Schomerus, C., Sevigny, J., Shukla, V, Zimmermann, H., Journal of Neurochemistry, 2007

Specificity of the ecto-ATPase inhibitor ARL 67156 on human and mouse ectonucleotidases, Lévesque, S.A., Lavoie, É.G., Lecka, J., Bigonnesse, F., Sévigny, J., British Journal of Pharmacology, 2007, 10.1038/sj.bjp.0707361

Stimulation of the P2Y1 receptor up-regulates nucleoside-triphosphate diphosphohydrolase-1 in human retinal pigment epithelial cells, Lu, W., Reigada, D., Sévigny, J., Mitchell, C.H., Journal of Pharmacology and Experimental Therapeutics, 2007, 10.1124/jpet.107.124545

The Nucleoside Triphosphate Diphosphohydrolase-1/CD39 Is Incorporated into Human Immunodeficiency Type 1 Particles, Where It Remains Biologically Active, Barat, C., Martin, G., Beaudoin, A.R., Sévigny, J., Tremblay, M.J., Journal of Molecular Biology, 2007, 10.1016/j.jmb.2007.05.012

Transforming growth factor-β and substrate stiffness regulate portal fibroblast activation in culture, Li, Z., Dranoff, J.A., Chan, E.P., Uemura, M., Sévigny, J., Wells, R.G., Hepatology, 2007, 10.1002/hep.21792

Transient changes in the localization and activity of ecto-nucleotidases in rat hippocampus following lipopolysaccharide treatment, Kittel, A., Sperlágh, B., Pelletier, J., Sévigny, J., Kirley, T.L., International Journal of Developmental Neuroscience, 2007, 10.1016/j.ijdevneu.2007.05.007

NTPDase7, Jean Sevigny, AfCS-Nature Molecule Pages, 2006, 10.1038/mp.a003166.01

Extracellular nucleotides mediate LPS‐induced IL‐8 release from monocytes and neutrophil migration., Filip Kukulski, Fethia Ben Yebdri, Julie Lefebvre, Sébastien Lévesque, Jean Sévigny, The FASEB Journal, 2006, 10.1096/fasebj.20.4.a203-b

Blue blocker glasses impede the capacity of bright light to suppress melatonin production, Sasseville, A., Paquet, N., Sévigny, J., Hébert, M., Journal of Pineal Research, 2006, 10.1111/j.1600-079X.2006.00332.x

Diadenosine and diuridine poly(borano)phosphate analogues: Synthesis, chemical and enzymatic stability, and activity at P2Y1 and P2Y 2 receptors, Nahum, V., Tulapurkar, M., Lévesque, S.A., Sévigny, J., Reiser, G., Fischer, B., Journal of Medicinal Chemistry, 2006, 10.1021/jm050955y

Extracelluar nucleotide signaling in adult neural stem cells: Synergism with growth factor-mediated cellular proliferation, Mishra, S.K., Braun, N., Shukla, V., Füllgrabe, M., Schomerus, C., Korf, H.-W., Gachet, C., Ikehara, Y., Sëvigny, J., Robson, S.C., Zimmermann, H., Development, 2006, 10.1242/dev.02233

Fluorescent N2,N3-ε-adenine nucleoside and nucleotide probes: Synthesis, spectroscopic properties, and biochemical evaluation, Sharon, E., Lévesque, S.A., Munkonda, M.N., Sévigny, J., Ecke, D., Reiser, G., Fischer, B., ChemBioChem, 2006, 10.1002/cbic.200600070

Immunolocalization of ectonucleotidases along the rat nephron, Vekaria, R.M., Shirley, D.G., Sévigny, J., Unwin, R.J., American Journal of Physiology - Renal Physiology, 2006, 10.1152/ajprenal.00151.2005

Nucleoside triphosphate diphosphohydrolase (NTPDase 8) and uses thereof, , Official Gazette of the United States Patent and Trademark Office Patents, 2006

Nucleoside triphosphate diphosphohydrolase-2 (NTPDase2/CD39L1) is the dominant ectonucleotidase expressed by rat astrocytes, Wink, M.R., Braganhol, E., Tamajusuku, A.S.K., Lenz, G., Zerbini, L.F., Libermann, T.A., Sévigny, J., Battastini, A.M.O., Robson, S.C., Neuroscience, 2006, 10.1016/j.neuroscience.2005.11.039

Nucleoside triphosphate diphosphohydrolase-2 is the ecto-ATPase of type I cells in taste buds, Bartel, D.L., Sullivan, S.L., Lavoie, É.G., Sévigny, J., Finger, T.E., Journal of Comparative Neurology, 2006, 10.1002/cne.20954

The E-NTPDase family of ectonucleotidases: Structure function relationships and pathophysiological significance, Robson, S.C., Sévigny, J., Zimmermann, H., Purinergic Signalling, 2006, 10.1007/s11302-006-9003-5

C-terminal splicing of NTPDase2 provides distinctive catalytic properties, cellular distribution and enzyme regulation, Wang, C.J.H., Vlajkovic, S.M., Braun, N., Zimmermann, H., Robson, S.C., Sévigny, J., Soeller, C., Thorne, P.R., Biochemical Journal, 2005, 10.1042/BJ20040852

Cloning and characterization of the ecto-nucleotidase NTPDase3 from rat brain: Predicted secondary structure and relation to other members of the E-NTPDase family and actin, Vorhoff, T., Zimmermann, H., Pelletier, J., Sévigny, J., Braun, N., Purinergic Signalling, 2005, 10.1007/s11302-005-6314-x

Comparative hydrolysis of P2 receptor agonists by NTPDases 1, 2, 3 and 8, Kukulski, F., Lévesque, S.A., Lavoie, É.G., Lecka, J., Bigonnesse, F., Knowles, A.F., Robson, S.C., Kirley, T.L., Sévigny, J., Purinergic Signalling, 2005, 10.1007/s11302-005-6217-x

Effect of P2 receptor antagonists and potential inhibitors on plasma membrane NTPDases., Lecka, J, Legendre, C, Levesque, SA, Sevigny, J, Gastroenterology, 2005

Erratum: Comparative hrydrolysis of P2 receptor agonists by NTPDases 1, 2, 3 and 8. (Purinergic Signalling (2005) vol. 1 (2) (193-204)), Kukulski, F., Levesque, S.A., Lavoie, E.G., Lecka, J., Bigonnesse, F., Knowles, A.F., Robson, S.C., Kirley, T.L., Sevigny, J., Purinergic Signalling, 2005, 10.1007/s11302-005-0383-8

Expression of NTPDase1 and NTPDase2 in murine kidney: Relevance to regulation of P2 receptor signaling, Kishore, B.K., Isaac, J., Fausther, M., Tripp, S.R., Shi, H., Gill, P.S., Braun, N., Zimmermann, H., Sévigny, J., Robson, S.C., American Journal of Physiology - Renal Physiology, 2005, 10.1152/ajprenal.00108.2004

Functional expression of the ecto-ATPase NTPDase2 and of nucleotide receptors by neuronal progenitor cells in the adult murine hippocampus, Shukla, V., Zimmermann, H., Wang, L., Kettenmann, H., Raab, S., Hammer, K., Sévigny, J., Robson, S.C., Braun, N., Journal of Neuroscience Research, 2005, 10.1002/jnr.20508

Identification of the long-known canalicular ecto-ATPase as the novel ecto-nucleotidase NTPDase8, Dranoff, J, Fausther, M, Lecka, J, Levesque, SA, Pelletier, J, Sevigny, J, Gastroenterology, 2005

Portal fibroblasts regulate the proliferation of bile duct epithelia via expression of NTPDase2, Jhandier, M.N., Kruglov, E.A., Lavoie, É.G., Sévigny, J., Dranoff, J.A., Journal of Biological Chemistry, 2005, 10.1074/jbc.M412371200

Association of the Ecto-ATPase NTPDase2 with Glial Cells of the Peripheral Nervous System, Braun, N., Sévigny, J., Robson, S.C., Hammer, K., Hanani, M., Zimmermann, H., GLIA, 2004, 10.1002/glia.10309

Beneficial effects of CD39/ecto-nucleoside triphosphate diphosphohydrolase-1 in murine intestinal ischemia-reperfusion injury, Guckelberger, O., Sun, X.F., Sévigny, J., Imai, M., Kaczmarek, E., Enjyoji, K., Kruskal, J.B., Robson, S.C., Thrombosis and Haemostasis, 2004

Blockade of P2Y receptors prevents cirrhosis due to carbon tetrachloride but not extrahepatic bile duct ligation, Dranoff, Jonathan A, Kruglov, Emma A, Robson, Simon, Sevigny, Jean, FASEB Journal, 2004

CD39/ecto-nucleoside triphosphate diphosphohydrolase-1 maintains vascular integrity in intestinal ischemia-reperfusion injury., Enjyoji, K, Guckelberger, O, Imai, M, Kaczmarek, E, Robson, SC, Sevigny, J, Sun, XF, American Journal of Transplantation, 2004

Cloning and characterization of mouse nucleoside triphosphate diphosphohydrolase-3, Lavoie, E.G., Kukulski, F., Lévesque, S.A., Lecka, J., Sévigny, J., Biochemical Pharmacology, 2004, 10.1016/j.bcp.2004.02.012

Cloning and Characterization of Mouse Nucleoside Triphosphate Diphosphohydrolase-8, Bigonnesse, F., Lévesque, S.A., Kukulski, F., Lecka, J., Robson, S.C., Fernandes, M.J.G., Sévigny, J., Biochemistry, 2004, 10.1021/bi0362222

Comparative hydrolysis of extracellular adenine nucleotides and adenosine in synaptic membranes from porcine brain cortex, hippocampus, cerebellum and medulla oblongata, Kukulski, F., Sévigny, J., Komoszyński, M., Brain Research, 2004, 10.1016/j.brainres.2004.09.044

Ectonucleotidase NTPDase2 is selectively down-regulated in biliary cirrhosis, Dranoff, J.A., Kruglov, E.A., Toure, J., Braun, N., Zimmermann, H., Jain, D., Knowles, A.F., Sévigny, J., Journal of Investigative Medicine, 2004

Expression of P2Y nucleotide receptors and ectonucleotidases in quiescent and activated rat hepatic stellate cells, Dranoff, J.A., Ogawa, M., Kruglov, E.A., Gaça, M.D.A., Sévigny, J., Robson, S.C., Wells, R.G., American Journal of Physiology - Gastrointestinal and Liver Physiology, 2004, 10.1152/ajpgi.00294.2003

Localization of nucleoside triphosphate diphosphohydrolase-1 (NTPDase1) and NTPDase2 in pancreas and salivary gland, Kittel, A., Pelletier, J., Bigonnesse, F., Guckelberger, O., Kordás, K., Braun, N., Robson, S.C., Sévigny, J., Journal of Histochemistry and Cytochemistry, 2004, 10.1369/jhc.3A6167.2004

Mutagenesis of N-glycosylation sites of human ecto-ATPase (E-NTPDase 2), Knowles, AF, Sevigny, J, Shindo, K, Faseb Journal, 2004

Noise exposure induces up-regulation of ecto-nucleoside triphosphate diphosphohydrolases 1 and 2 in rat cochlea, Vlajkovic, S.M., Housley, G.D., Muñoz, D.J.B., Robson, S.C., Sévigny, J., Wang, C.J.H., Thorne, P.R., Neuroscience, 2004, 10.1016/j.neuroscience.2004.04.023

NTPDase2 is necessary for regulation of bile duct epithelial proliferation by portal fibroblasts, Dranoff, Jonathan A, Jhandier, Muhammad N, Kruglov, Emma A, Sevigny, Jean, FASEB Journal, 2004

p21Waf1/Cip1 in endothelial cell survival, Aoudjit, F., Sévigny, J., Cardiovascular Research, 2004, 10.1016/j.cardiores.2004.01.003

Regulation of liver fibrosis by P2Y nucleotide receptors, Dranoff, JA, Gaca, M, Kruglov, EA, Robson, SC, Sevigny, J, Wells, RG, Gastroenterology, 2004

RPE cells express both NTPDasel and NTPDase2: resulting ADP can increase cell calcium, Laties, AM, Lu, W, McGlinn, A, Mitchell, CH, Pendrak, K, Reigada, D, Sevigny, J, Stone, RA, Investigative Ophthalmology & Visual Science, 2004

Targeted disruption of cd73/ecto-5′-nucleotidase alters thromboregulation and augments vascular inflammatory response, Koszalka, P., Özüyaman, B., Huo, Y., Zernecke, A., Flögel, U., Braun, N., Buchheiser, A., Decking, U.K.M., Smith, M.L., Sévigny, J., Gear, A., Weber, A.-A., Molojavyi, A., Ding, Z., Weber, C., Ley, K., Zimmermann, H., Gödecke, A., Schrader, J., Circulation Research, 2004, 10.1161/01.RES.0000144796.82787.6f

Expression of the ecto-ATPase NTPDase2 in the germinal zones of the developing and adult rat brain, Braun, N., Sévigny, J., Mishra, S.K., Robson, S.C., Barth, S.W., Gerstberger, R., Hammer, K., Zimmermann, H., European Journal of Neuroscience, 2003, 10.1046/j.1460-9568.2003.02567.x

Nucleotide signaling in quiescent and activated hepatic stellate cells., Dranoff, Jonathan Ankin, Gaca, Mariana D. A., Kruglov, Emma A., Sevigny, Jean, Wells, Rebecca G., FASEB Journal, 2003

The ecto-ATPase NTPDase2 is associated with a subset of astrocytic cells in the germinal zones of the adult rodent brain., , Society for Neuroscience Abstract Viewer and Itinerary Planner, 2003

The ecto-ATPase NTPDase2 is expressed by astrocytic type-B cells of the adult neurogenic subventricular zone and in germinal zones of the developing rat brain, , Glia, 2003

The ecto-nucleotidase NTPDase2 is selectively down-regulated in biliary fibrosis., , Hepatology, 2003

CD39 is the dominant Langerhans cell-associated ecto-NTPDase: Modulatory roles in inflammation and immune responsiveness, Mizumoto, N., Kumamoto, T., Robson, S.C., Sévigny, J., Matsue, H., Enjyoji, K., Takashima, A., Nature Medicine, 2002, 10.1038/nm0402-358

Cloning of the hepatic canalicular ecto-atpase: Identification as a novel nucleoside triphosphate diphosphohydrolase., , Hepatology, 2002

Cochlear distribution of NTPDase1 and 2., Housley, Gary D., Robson, Simon C., Sevigny, Jean, Thorne, Peter R., Vlajkovic, Srdjan M., Drug Development Research, 2002

Differential catalytic properties and vascular topography of murine nucleoside triphosphate diphosphohydrolase 1 (NTPDase1) and NTPDase2 have implications for thromboregulation, Sévigny, J., Sundberg, C., Braun, N., Guckelberger, O., Csizmadia, E., Qawi, I., Imai, M., Zimmermann, H., Robson, S.C., Blood, 2002, 10.1182/blood.V99.8.2801

Distribution of ectonucleoside triphosphate diphosphohydrolases 1 and 2 in rat cochlea, Vlajkovic, S.M., Thorne, P.R., Sévigny, J., Robson, S.C., Housley, G.D., Hearing Research, 2002, 10.1016/S0378-5955(02)00460-4

Ecto-nucleotidases: Multiplicity and role in the nervous system, Braun, N, Failer, BU, Robson, SC, Sevigny, J, Vollmayer, P, Zimmermann, HI, Drug Development Research, 2002

Identification and isolation of a novel liver cell type expressing the ecto-nucleotidase NTPDase 2, Braun, N, Dranoff, JA, Kruglov, EA, Robson, SC, Sevigny, J, Zimmerman, H, Gastroenterology, 2002

Identification of a novel ecto-nucleoside triphoshphate diphosphohydrolase from the liver of the little skate Raja erinacea, Dranoff, JA, Kruglov, E, Petell, L, Sevigny, J, Zarrella, K, Gastroenterology, 2002

Localization of CD39/vascular NTP diphosphohydrolase (NTPDase) in rat kidney., Isaac, J, Kishore, BK, Robson, SC, Sevigny, J, Tripp, SR, Journal of the American Society of Nephrology, 2002

Localization of CD39L1/vascular NTP diphosphohydrolase (NTPDase2) in murine kidney., Isaac, J, Kishore, BK, Robson, SC, Sevigny, J, Journal of the American Society of Nephrology, 2002

NTPDase1 and NTPDase2 immunolocalization in mouse cochlea: Implications for regulation of P2 receptor signaling, Vlajkovic, S.M., Thorne, P.R., Sévigny, J., Robson, S.C., Housley, G.D., Journal of Histochemistry and Cytochemistry, 2002

The ecto-nucleoside triphosphate diphosphohydrolase NTPDase2/CD39l1 is expressed in a novel functional compartment within the liver, Dranoff, J.A., Kruglov, E.A., Robson, S.C., Braun, N., Zimmermann, H., Sévigny, J., Hepatology, 2002, 10.1053/jhep.2002.36823

Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplants, Sato, K., Balla, J., Otterbein, L., Smith, R.N., Brouard, S., Lin, Y., Csizmadia, E., Sevigny, J., Robson, S.C., Vercellotti, G., Choi, A.M., Bach, F.H., Soares, M.P., Journal of Immunology, 2001

Disordered cellular migration and angiogenesis in cd39-null mice, Goepfert, C., Sundberg, C., Sévigny, J., Enjyoji, K., Hoshi, T., Csizmadia, E., Robson, S., Circulation, 2001

Expression of ecto-nucleoside triphosphate diphosphohydrolase 2 (NTPDase2) in non-myelinating Schwann cells, Braun, N., Robson, S. C., Sevigny, J., Zimmermann, H., Society for Neuroscience Abstracts, 2001

Identification and characterization of membrane-associated hepatic NTP diphosphohydrolases., Braun, N, Csizmadia, E, Dranoff, JA, Kirley, T, Kruglov, E, Lemmens, R, Robson, SC, Sevigny, J, Smith, RN, Zimmermann, H, Hepatology, 2001

Mammalian ATP-diphosphohydrolases and process of purification thereof, , Official Gazette of the United States Patent and Trademark Office Patents, 2001

Modulation of extracellular nucleotide-mediated signaling by CD39/nucleoside triphosphate diphosphohydrolase-1, Robson, S.C., Enjyoji, K., Goepfert, C., Imai, M., Kaczmarek, E., Lin, Y., Sévigny, J., Warny, M., Drug Development Research, 2001, 10.1002/ddr.1188

P2Y6 Nucleotide Receptor Mediates Monocyte Interleukin-8 Production in Response to UDP or Lipopolysaccharide, Warny, M., Aboudola, S., Robson, S.C., Sévigny, J., Communi, D., Soltoff, S.P., Kelly, C.P., Journal of Biological Chemistry, 2001, 10.1074/jbc.M102568200

Targeting platelet aggregation: CD39 gene transfer augments nucleoside triphosphate diphosphohydrolase activity in injured rabbit arteries, Gangadharan, S.P., Imai, M., Rhynhart, K.K., Sévigny, J., Robson, S.C., Conte, M.S., Surgery, 2001, 10.1067/msy.2001.116032

The C-terminal cysteine-rich region dictates specific catalytic properties in chimeras of the ectonucleotidases NTPDase1 and NTPDase2, Heine, P., Braun, N., Sévigny, J., Robson, S.C., Servos, J., Zimmermann, H., European Journal of Biochemistry, 2001, 10.1046/j.1432-1327.2001.01896.x

The nucleotide triphosphate dihydrolases CD39 and CD39L1 are expressed in distinct compartments within the rat liver, , Gastroenterology, 2001, 10.1016/S0016-5085(08)80449-0

Assignment of ecto-nucleoside triphosphate diphosphohydrolase-1/cd39 expression to microglia and vasculature of the brain, Braun, N, Sevigny, J, Robson, SC, Enjyoji, K, Guckelberger, O, Hammer, K, Di Virgilio, F, Zimmermann, H, European Journal of Neuroscience, 2000, 10.1046/J.1460-9568.2000.01342.X

Carbon monoxide can fully substitute heme oxygenase-1 in suppressing the rejection of mouse to rat cardiac transplants, Anrather, Josef, Bach, Fritz H., Balla, Jozsef, Brouard, Sophie, Choi, Augustine M., Csizmadia, Eva, Lin, Yuan, Otterbein, Leo, Robson, Simon C., Sato, Koichiro, Sevigny, Jean, Smith, Neal, Soares, Miguel P., Vercellotti, Gregory, Acta Haematologica (Basel), 2000

CD39/vascular ATP diphosphohydrolase modulates xenograft survival, Imai, M., Takigami, K., Guckelberger, O., Lin, Y., Sevigny, J., Kaczmarek, E., Goepfert, C., Enjyoji, K., Bach, F.H., Rosenberg, R.D., Robson, S.C., Transplantation Proceedings, 2000, 10.1016/S0041-1345(00)01065-4

Distribution, cloning, and characterization of porcine nucleoside triphosphate diphosphohydrolase-1, Lemmens, R., Vanduffel, L., Kittel, A., Beaudoin, A.R., Benrezzak, O., Sévigny, J., European Journal of Biochemistry, 2000, 10.1046/j.1432-1327.2000.01462.x

Identification and characterization of a novel hepatic canalicular ATP diphosphohydrolase, Sévigny, J., Robson, S.C., Waelkens, E., Csizmadia, E., Smith, R.N., Lemmens, R., Journal of Biological Chemistry, 2000, 10.1074/jbc.275.8.5640

Identification, characterization, and immunolocalization of a nucleoside triphosphate diphosphohydrolase in pig liver, Leclerc, M.-C., Grondin, G., Gendron, F.-P., Sévigny, J., Beaudoin, A.R., Archives of Biochemistry and Biophysics, 2000, 10.1006/abbi.2000.1800

Impaired hepatic regeneration in liver-specific insulin receptor knockout, Jean Sevigny, Transplantation, 2000

Palmitoylation targets CD39/endothelial ATP diphosphohydrolase to caveolae, Koziak, K., Kaczmarek, E., Kittel, A., Sévigny, J., Blusztajn, J.K., Schulte am Esch II, J., Imai, M., Guckelberger, O., Goepfert, C., Qawi, I., Robson, S.C., Journal of Biological Chemistry, 2000, 10.1074/jbc.275.3.2057

Purification, characterization, and localization of an ATP diphosphohydrolase in porcine kidney, Lemmens, R., Kupers, L., Sévigny, J., Beaudoin, A.R., Grondin, G., Kittel, A., Waelkens, E., Vanduffel, L., American Journal of Physiology - Renal Physiology, 2000

Thromboregulatory potential of endothelial CD39/nucleoside triphosphate diphosphohydrolase: Modulation of purinergic signalling in platelets, Robson, S.C., Sévigny, J., Imai, M., Guckelberger, O., Enjyoji, K., Expert Opinion on Therapeutic Targets, 2000, 10.1517/14728222.4.2.155

Analysis of CD39/ATP diphosphohydrolase (ATPDase) expression in endothelial cells, platelets and leukocytes, Koziak, K., Sévigny, J., Robson, S.C., Siegel, J.B., Kaczmarek, E., Thrombosis and Haemostasis, 1999

Canalicular ecto-ATPase is a novel member of the GDA 1/CD39 NTPase family., , Hepatology, 1999

CD39 as a caveolar-associated ectonucleotidase, Kittel, A., Kaczmarek, E., Sevigny, J., Lengyel, K., Csizmadia, E., Robson, S.C., Biochemical and Biophysical Research Communications, 1999, 10.1006/bbrc.1999.1254

CD39 is a caveolar-associated ectonucleotidase, , Journal of Neurochemistry, 1999

Characterization of a novel ATP diphosphohydrolase/CD39-like protein, , The FASEB Journal, 1999

Disordered hemostasis and thromboregulation in cd39-deficient mice, , The FASEB Journal, 1999

Identification and immunolocalization of two isoforms of ATP- diphosphohydrolase (ATPDase) in the pig immune system, Benrezzak, O., Grondin, G., Sévigny, J., Gendron, F.-P., Rousseau, E., D'Orléans-Juste, P., Beaudoin, A.R., Archives of Biochemistry and Biophysics, 1999, 10.1006/abbi.1999.1401

Inhibition of ATPDase/CD30 in human vascular endothelial cells by antisense oligonucleotides, , The FASEB Journal, 1999

Modulation of nucleotide triphosphate diphosphohydrolase-1 (NTPDase-1)/cd39 in xenograft rejection, Imai, M., Takigami, K., Guckelberger, O., Enjyoji, K., Smith, R.N., Lin, Y., Csizmadia, E., Sévigny, J., Rosenberg, R.D., Bach, F.H., Robson, S.C., Molecular Medicine, 1999

Structural elements and limited proteolysis of CD39 influence ATP diphosphohydrolase activity, Schulte Am Esch II, J., Sévigny, J., Kaczmarek, E., Siegel, J.B., Imai, M., Koziak, K., Beaudoin, A.R., Robson, S.C., Biochemistry, 1999, 10.1021/bi982426k

Suppression of ATP diphosphohydrolase/CD39 in human vascular endothelial cells, Imai, M., Kaczmarek, E., Koziak, K., Sévigny, J., Goepfert, C., Guckelberger, O., Csizmadia, E., Schulte Am Esch II, J., Robson, S.C., Biochemistry, 1999, 10.1021/bi990543p

Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation, Enjyoji, K., Sévigny, J., Lin, Y., Frenette, P.S., Christie, P.D., Am Esch II, J.S., Imai, M., Edelberg, J.M., Rayburn, H., Lech, M., Beeler, D.L., Csizmadia, E., Wagner, D.D., Robson, S.C., Rosenberg, R.D., Nature Medicine, 1999, 10.1038/12447

ATP-diphosphohydrolases, , Official Gazette of the United States Patent and Trademark Office Patents, 1998

Demonstration and immunolocalization of ATP diphosphohydrolase in the pig digestive system, Sevigny, J., Grondin, G., Gendron, F.-P., Roy, J., Beaudoin, A.R., American Journal of Physiology - Gastrointestinal and Liver Physiology, 1998

Prevention and reversal of thrombotic and inflammatory processes, Beaudoin, A.R., Sévigny, J., Gendron, F.-P., St George, M., Leclerc, M.-C., Expert Opinion on Therapeutic Targets, 1998, 10.1517/14728222.2.1.61

Structural and post-translational modifications of ATP diphosphohydrolase/CD39, Sevigny, J, Esch, JSA, Kaczmarek, E, Robson, SC, Blood, 1998

Characterization and mutagenesis of CD39/vascular ATP diphosphohydrolase, , Circulation, 1997

Characterization of CD39/vascular ATP diphosphohydrolase (ATPDase), Robson, S.C., Kaczmarek, E., Koziak, K., Siegel, J., Sevigny, J., Beaudoin, A.R., Bach, F.H., FASEB Journal, 1997

Distribution of different ATP-diphosphohydrolase isoforms in mammalian organs, Beaudoin, AR, Grondin, G, Sevigny, J, ECTO-ATPASES, 1997, 10.1007/978-1-4615-5955-9_5

Mutagenesis of vascular ATP diphosphohydrolase, Esch, JSA, Kaczmarek, E, Siegel, JB, Koziak, K, Sevigny, J, Imai, M, Beaudoin, AR, Bach, FH, Robson, SC, Blood, 1997

Purification and identification by immunological techniques of different isoforms of mammalian ATP diphosphohydrolases, Sevigny, J, Dumas, F, Beaudoin, AR, ECTO-ATPASES, 1997, 10.1007/978-1-4615-5955-9_18

Purification and immunohistochemical localization of the ATP diphosphohydrolase in bovine lungs, Sévigny, J., Picher, M., Grondin, G., Beaudoin, A.R., American Journal of Physiology - Lung Cellular and Molecular Physiology, 1997

Purification of the blood vessel ATP diphosphohydrolase, identification and localisation by immunological techniques, Sévigny, J., Levesque, F.P., Grondin, G., Beaudoin, A.R., Biochimica et Biophysica Acta - General Subjects, 1997, 10.1016/S0304-4165(96)00079-7

Purification, characterization, and localization of two ATP diphosphohydrolase isoforms in bovine heart, Beaudoin, A.R., Sévigny, J., Grondin, G., Daoud, S., Levesque, F.P., American Journal of Physiology - Heart and Circulatory Physiology, 1997

Vascular ATP diphosphohydrolase (CD39/ATPDase), Kaczmarek, E, Siegel, JB, Sevigny, J, Koziak, K, Hancock, WW, Beaudoin, A, Bach, FH, Robson, SC, ECTO-ATPASES, 1997, 10.1007/978-1-4615-5955-9_22

ATP-diphosphohydrolases, apyrases, and nucleotide phosphohydrolases. Biochemical properties and functions, Beaudoin, A.R., Sévigny, J., Picher, M., Biomembranes: A Multi-Volume Treatise, 1996, 10.1016/S1874-5342(06)80015-2

Hydrolysis of P2-purinoceptor agonists by a purified ectonucleotidase from the bovine aorta, the ATP-diphosphohydrolase, Picher, M., Sévigny, J., D'Orléans-Juste, P., Beaudoin, A.R., Biochemical Pharmacology, 1996, 10.1016/0006-2952(96)00086-X

Identification and characterization of CD39/vascular ATP diphosphohydrolase, Kaczmarek, E., Koziak, K., Sévigny, J., Siegel, J.B., Anrather, J., Beaudoin, A.R., Bach, F.H., Robson, S.C., Journal of Biological Chemistry, 1996, 10.1074/jbc.271.51.33116

Identification of the catalytic subunit of the bovine lung ATP-diphosphohydrolase, , Molecular Biology of the Cell, 1995

Purification of pancreas type-I ATP diphosphohydrolase and identification by affinity labelling with the 5'-p-fluorosulphonylbenzoyladenosine ATP analogue, Sevigny, J., Cote, Y.P., Beaudoin, A.R., Biochemical Journal, 1995

The bovine aorta ATP-diphosphohydrolase, an ectoenzyme involved in the hydrolysis of P-2-purinoceptor agonists, , Molecular Biology of the Cell, 1995

An open window on the world of extracellular nucleotides and the potential role of the ATP-diphosphohydrolase | LE MONDE DES NUCLEOTIDES EXTRACELLULAIRES, Sevigny, J., Beaudoin, A.R., Medecine/Sciences, 1994

Découvrez nos professeurs et professeures!

Jean Sévigny

Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Immunologie-infectiologie

Santé cardiovasculaire, respiratoire et métabolisme

Transfert des connaissances

Domaines et intérêts de recherche du (de la) professeur(e) :

Appareil locomoteur et arthrite

Maladies infectieuses et immunitaires

Nutrition et métabolisme

Santé circulatoire et respiratoire

Projets de recherche

Publications

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Encadrement d'étudiant(e)s pour les programmes suivants :

Biologie cellulaire et moléculaire

Médecine moléculaire

Microbiologie-immunologie

Sciences cliniques et biomédicales

Disponibilité d'encadrement d'étudiant(e)s

Direction et personnes-ressources