Jean Sévigny

Design, synthesis and in vitro and evaluation of novel nalidixic acid derivatives as potent ectonucleotidases inhibitorspublié le 2025-10

Assessing Ecto-5’-Nucleotidase/CD73 Expression and Malignancy Parameters in Early- and Late- Passage C6 Glioma Cellspublié le 2025-06

Synthesis, Characterization, Interactions, and Immunomodulatory Function of Ectonucleotidase CD39/CD73 Inhibitor 8-Butylthioadenosine 5′-Monophosphatepublié le 2025-05-09

CD39 delineates chimeric antigen receptor regulatory T cell subsets with distinct cytotoxic & regulatory functions against human isletspublié le 2024-06-28

Endometrial epithelial cell organoids as tools for studying the CD39 family of enzymes and for validating enzyme inhibitors.publié le 2024-06-17

Synthesis, in vitro, and in silico studies of morpholine-based thiosemicarbazones as ectonucleotide pyrophosphatase/phosphodiesterase-1 and -3 inhibitors.publié le 2024-03-24

Extracellular nucleotides in smooth muscle contractionpublié le 2024-02

Design, synthesis and in vitro evaluation of novel sulfonylurea and sulfonylthiourea as ectonucleotidases inhibitorspublié le 2024-01

Synthesis and biological evaluation of sulfamoyl benzamide derivatives as selective inhibitors for h-NTPDasespublié le 2023

Synthesis of new class of indole acetic acid sulfonate derivatives as ectonucleotidases inhibitorspublié le 2023

Preclinical evaluation of bozepinib in bladder cancer cell lines: modulation of the NPP1 enzyme.publié le 2023-10-31

NTPDase1/CD39 Ectonucleotidase Is Necessary for Normal Arterial Diameter Adaptation to Flowpublié le 2023-10-10

UTP increases wound healing in the self assembled skin substitute (SASS)publié le 2023-09

Heparins are potent inhibitors of ectonucleotide pyrophosphatase/phospho-diesterase-1 (NPP1) – a promising target for the immunotherapy of cancerpublié le 2023-08-29

Resistance training reduces platelet activation in hypertensive women: the role of purinergic signalingpublié le 2023-08-10

Synthesis of Thieno[3,2-d]pyrimidine Derivatives through Sequential SNAr and Suzuki Reactions as Selective h-NTPDases Inhibitorspublié le 2023-07-17

Synthesis and structure–activity relationships of ticlopidine derivatives and analogs as inhibitors of ectonucleotidase CD39publié le 2023-06

Epidermal melanocytes metabolize extracellular nucleotides by purinergic enzymespublié le 2023-06-01

Stomach-derived human insulin-secreting organoids restore glucose homeostasispublié le 2023-05

Exploring chromone sulfonamides and sulfonylhydrazones as highly selective ectonucleotidase inhibitors: Synthesis, biological evaluation and in silico studypublié le 2023-05

Synthesis and biological evaluation of sulfamate derivatives as inhibitors of carbonic anhydrases II and IXpublié le 2023-05

Tumor-neutrophil crosstalk promotes in vitro and in vivo glioblastoma progressionpublié le 2023-05-24

Silencing NTPDase3 activity rehabilitates the osteogenic commitment of post-menopausal stem cell bone progenitorspublié le 2023-04-19

Synthesis of new sulphonate derivatives containing adamantane and 4-chlorophenyl moieties as nucleotide pyrophosphatase/phosphodiesterase-1 and -3 inhibitorspublié le 2023-02

Leishmania infantum NTPDase1 and NTPDase2 play an important role in infection and nitric oxide production in macrophagespublié le 2023-01

Bioscaffold developed with decellularized human amniotic membrane seeded with mesenchymal stromal cells: assessment of efficacy and safety profiles in a second-degree burn preclinical modelpublié le 2023-01-01

The Purinergic Receptor P2X4 Promotes Th17 Activation and the Development of Arthritispublié le 2022

Synthesis and pharmacological characterization of multiply substituted 2H-chromene derivatives as P2Y6 receptor antagonistspublié le 2022

Homeostasis of extracellular ATP in uninfected RBCs from a Plasmodium falciparum culture and derived microparticlespublié le 2022

Synthesis and Biological Evaluation of Arylamide Sulphonate Derivatives as Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 and -3 Inhibitorspublié le 2022

NTPDase8 protects mice from intestinal inflammation by limiting P2Y6 receptor activation: identification of a new pathway of inflammation for the potential treatment of IBDpublié le 2022

HIGHLY SELECTIVE AND POTENT NPP1 INHIBITORS BASED ON URIDINE-5'-P,-DITHIOPHOSPHATE ANALOGUESpublié le 2022

Protein kinase inhibitor ceritinib blocks ectonucleotidase CD39 - a promising target for cancer immunotherapypublié le 2022

Synthesis, characterization and biological evaluation of thiadiazole amide derivatives as nucleoside triphosphate diphosphohydrolases (NTPDases) inhibitorspublié le 2022

Identification of thienopyrimidine glycinates as selective inhibitors for h-NTPDasespublié le 2022-12

Design and synthesis of new adamantyl derivatives as promising antiproliferative agents.publié le 2022-11-26

Diacylhydrazine Derivatives of 2-(5-(Pyridin-3-yl)-2H-Tetrazol-2-yl)Acetohydrazide and 2-(5-(Pyridin-4-yl)-2H-Tetrazol-2-yl)Acetohydrazide as Potential Inhibitors of Nucleotide Pyrophosphatasepublié le 2022-10

Characterization of the Endometrial MSC Marker Ectonucleoside Triphosphate Diphosphohydrolase-2 (NTPDase2/CD39L1) in Low- and High-Grade Endometrial Carcinomas: Loss of Stromal Expression in the Invasive Phenotypespublié le 2021

Neutrophils: fast and furious-the nucleotide pathwaypublié le 2021

Extracellular ATP hydrolysis in Caco-2 human intestinal cell linepublié le 2021

Antenatal Dexamethasone Treatment Induces Sex-dependent Upregulation of NTPDase1/CD39 and Ecto-5'-nucleotidase/CD73 in the Rat Fetal Brainpublié le 2021

Synthesis, biological evaluation, and docking studies of novel pyrrolo[2,3-b]pyridine derivatives as both ectonucleotide pyrophosphatase/phosphodiesterase inhibitors and antiproliferative agentspublié le 2021

Identification and Expression Analysis of CD73 Inhibitors in Cervical Cancerpublié le 2021

Influence of NSAIDs and methotrexate on CD73 expression and glioma cell growthpublié le 2021

Synthesis, In-vitro evaluation and molecular docking studies of oxoindolin phenylhydrazine carboxamides as potent and selective inhibitors of ectonucleoside triphosphate diphosphohydrolase (NTPDase)publié le 2021

Editorial: Metalloenzymes: Potential Drug Targetspublié le 2021

NTPDase1 Modulates Smooth Muscle Contraction in Mice Bladder by Regulating Nucleotide Receptor Activation Distinctly in Male and Femalepublié le 2021

Synthesis, characterization, alkaline phosphatase inhibition assay and molecular modeling studies of 1-benzylidene-2-(4-tert- butylthiazol-2-yl) hydrazinespublié le 2021

Sulfated Polysaccharides from Macroalgae Are Potent Dual Inhibitors of Human ATP-Hydrolyzing Ectonucleotidases NPP1 and CD39publié le 2021

Global deletion of NTPDase3 protects against diet-induced obesity by increasing basal energy metabolismpublié le 2021

Extracellular ectonucleotidases are differentially regulated in murine tissues and human polymorphonuclear leukocytes during sepsis and inflammationpublié le 2021

Divergent synthesis and elaboration of structure activity relationship for quinoline derivatives as highly selective NTPDase inhibitorpublié le 2021

2‐Substituted thienotetrahydropyridine derivatives: Allosteric ectonucleotidase inhibitorspublié le 2021-12

New insights into cytotoxic mechanisms of bozepinib against glioblastomapublié le 2021-07