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Jacques Côté

Professeur titulaire

Jacques Côté
jacques.cote.8@ulaval.ca
Regroupement québécois de recherche sur la fonction, la structure et l'ingénierie des protéines
Centre de recherche sur le cancer
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Oncologie
Reproduction, génétique, périnatalité et développement

Domaines et intérêts de recherche du (de la) professeur(e) :

Subcellulaire
  • Acides nucléiques
  • Enzymes et protéines
Cancer
  • Carcinogénèse
  • Division cellulaire
  • Gène suppresseur
  • Génétique du cancer
  • Oncogènes
  • Signalisation cellulaire et cancer
Génomique et protéomique
  • Mécanismes biologiques et biochimiques
  • Protéomique fonctionnelle et structurale
Organisation et fonctions biologiques

Projets de recherche

  • Functional analysis of the NuA4/TIP60 complex in epigenetic mechanisms linked to genome expression and stability - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2022-10-01 au 2027-09-30
  • Role of MYST-ING acetyltransferase complexes in transcription regulation, cell fate and disease - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2022-07-01 au 2027-06-30
  • Functional analysis of the NuA4/TIP60 complex in epigenetic mechanisms linked to genome expression and stability - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2022-03-01 au 2027-03-31
  • Defining nucleosome features regulating the function of chromatin modifiers and remodelers - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2022-04-01 au 2027-03-31
  • Mécanismes moléculaires orchestrant la transition épithélio-mésenchymateuse - Fonds de recherche du Québec - Nature et technologies - Projet de recherche en équipe, co-chercheur - 2023-04-01 au 2026-03-31
  • Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
  • Tetrahymena thermophila - un model évolutionnaire divergent pour découvrir de nouveau modes de régulation transcriptionnelle - Conseil de recherches en sciences naturelles et génie Canada, Fonds de recherche du Québec - Nature et technologies - Programme NOVA- FRQNT-CRSNG pour chercheurs et chercheuses en début de carrière (PILOTE), co-chercheur - 2022-03-15 au 2025-03-14
  • Understanding the molecular determinants of high-grade endometrial stromal sarcomas - Société de recherche sur le cancer - Subvention de fonctionnement, chercheur principal - 2022-09-01 au 2024-08-31
  • Plateforme de culture cellulaire pour l'analyse fonctionnelle de modificateurs épigénétiques liés aux maladies humaines - Fondation Canadienne pour l'innovation (La), Ministère de la Santé et des Services sociaux - Fonds des leaders John-R.-Evans (FLJR), chercheur principal - 2022-04-01 au 2023-09-28
  • Gene Application to engage a Model Organism Researcher – ING3 - Instituts de recherche en santé du Canada - Réseau catalyseur de la recherche : maladies rares, chercheur principal - 2021-09-01 au 2022-08-31
  • Control of Genome Expression and Maintenance by MYST-ING Tumor Suppressor Complexes. - Instituts de recherche en santé du Canada - Subventions Fondation, chercheur principal - 2015-07-01 au 2022-06-30
  • Chaire de recherche du Canada en biologie de la chromatine et épigénétique moléculaire - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2015-01-01 au 2021-12-31

Publications

  • Primers for mitochondrial DNA replication generated by endonuclease G, Ruiz-Carrillo, A., Côté, J., Science, 1993, 10.1126/science.7688144
  • NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities, Wang, W., Côté, J., Young, M.K., Moreno, G.T., Wong, J., Xue, Y., Molecular Cell, 1998, 10.1016/S1097-2765(00)80299-3
  • NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p, Côté, J., Workman, J.L., Pillus, L., Brandl, C.J., Grant, P., Clarke, A., Savard, J., Utley, R.T., Allard, S., EMBO Journal, 1999, 10.1093/emboj/18.18.5108
  • Structural and Functional Conservation of the NuA4 Histone Acetyltransferase Complex from Yeast to Humans, Côté, J., Tan, S., Lane, W.S., Selleck, W., Doyon, Y., Molecular and Cellular Biology, 2004, 10.1128/MCB.24.5.1884-1896.2004
  • The highly conserved and multifunctional NuA4 HAT complex, Côté, J., Doyon, Y., Current Opinion in Genetics and Development, 2004, 10.1016/j.gde.2004.02.009
  • Competitive recruitment of CBP and Rb-HDAC regulates UBF acetylation and ribosomal transcription, Moss, T., Côté, J., Rothblum, L.I., Savard, J., Hirschler-Laszkiewicz, I., Faubladier, M., Stefanovsky, V.Y., Pelletier, G., Molecular Cell, 2000, 10.1016/S1097-2765(00)00104-0
  • Differential remodeling of the HIV-1 nucleosome upon transcription activators and SWI/SNF complex binding, Dimitrov, S., Khochbin, S., Côté, J., Seve, M., Charra, M., Angelov, D., Journal of Molecular Biology, 2000, 10.1006/jmbi.2000.4069
  • Multiple links between the NuA4 histone acetyltransferase complex and epigenetic control of transcription, Côté, J., Stillman, D.J., Lane, W.S., Savard, J., Allard, S., Héliot, L., Zhang, Y., Nourani, A., Boudreault, A.A., Galarneau, L., Molecular Cell, 2000, 10.1016/S1097-2765(00)80258-0
  • ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation, Côté, J., Yang, X.-J., Tan, S., Lane, W.S., Selleck, W., Côté, V., Landry, A.-J., Ullah, M., Cayrou, C., Doyon, Y., Molecular Cell, 2006, 10.1016/j.molcel.2005.12.007
  • ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression, Gozani, O., Chua, K.F., Côté, J., Shi, Y., Kutateladze, T.G., Ayer, D.E., Cairns, B.R., Saha, A., Davrazou, F., Cayrou, C., Lacoste, N., Kaadige, M.R., Lan, F., Peña, P., Carney, D., Hung, T., Michishita, E., Ewalt, M., Hong, T., Walter, K.L., Shi, X., Nature, 2006, 10.1038/nature04835
  • A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16, Lucchesi, J.C., Côté, J., Lane, W.S., Huang, R., Cayrou, C., Smith, E.R., Molecular and Cellular Biology, 2005, 10.1128/MCB.25.21.9175-9188.2005
  • Regulation of NuA4 histone acetyltransferase activity in transcription and DNA repair by phosphorylation of histone H4, Côté, J., Allard, S., Jobin-Robitaille, O., Lacoste, N., Utley, R.T., Molecular and Cellular Biology, 2005, 10.1128/MCB.25.18.8179-8190.2005
  • Cellular machineries for chromosomal DNA repair, Côté, J., Peterson, C.L., Genes and Development, 2004, 10.1101/gad.1182704
  • Identification and Analysis of Native HAT Complexes, Grant, P.A., Côté, J., Doyon, Y., McMahon, S.J., Methods in Enzymology, 2004, 10.1016/S0076-6879(03)77008-6
  • Recruitment of the NuA4 complex poises the PHO5 promoter for chromatin remodeling and activation, Côté, J., Allard, S., Utley, R.T., Nourani, A., EMBO Journal, 2004, 10.1038/sj.emboj.7600230
  • Perceiving the epigenetic landscape through histone readers, Kutateladze, T.G., Côté, J., Lalonde, M.-E., Musselman, C.A., Nature Structural and Molecular Biology, 2012, 10.1038/nsmb.2436
  • MYST-family histone acetyltransferases: Beyond chromatin, Côté, J., Sapountzi, V., Cellular and Molecular Life Sciences, 2011, 10.1007/s00018-010-0599-9
  • NuA4-dependent acetylation of nucleosomal histones H4 and H2A directly stimulates incorporation of H2A.Z by the SWR1 complex, Côté, J., Gaudreau, L., Utley, R.T., Lacoste, N., Bouchard, N., Cramet, M., Piquet, S., Brodeur, J., Monnet-Saksouk, J., Auger, A., Altaf, M., Journal of Biological Chemistry, 2010, 10.1074/jbc.M110.117069
  • Dissection of Rad9 BRCT domain function in the mitotic checkpoint response to telomere uncapping, Kron, S.J., Côté, J., Altaf, M., Nnakwe, C.C., DNA Repair, 2009, 10.1016/j.dnarep.2009.09.010
  • Role of Jade-1 in the histone acetyltransferase (HAT) HBO1 complex, Panchenko, M.V., Côté, J., Vaziri, C., Cayrou, C., Saksouk, N., Cohen, H.T., Chitalia, V.C., Ihn, Y.S., Foy, R.L., Journal of Biological Chemistry, 2008, 10.1074/jbc.M801407200
  • Functions of MYST family histone acetyltransferases and their link to disease, Côté, J., Avvakumov, N., Sub-Cellular Biochemistry, 2007
  • Interplay of Chromatin Modifiers on a Short Basic Patch of Histone H4 Tail Defines the Boundary of Telomeric Heterochromatin, Côté, J., Briggs, S.D., Tan, S., Lacoste, N., Utley, R.T., Altaf, M., Molecular Cell, 2007, 10.1016/j.molcel.2007.12.002
  • Regulating chromatin by histone acetylation, Côté, J., Rossetto, D., Steunou, A.-L., Fundamentals of Chromatin, 2014, 10.1007/978-1-4614-8624-4_4
  • Exchange of associated factors directs a switch in HBO1 acetyltransferase histone tail specificity, Côté, J., Kutateladze, T.G., Yang, X.-J., Tan, S., Klein, B.J., Tong, Q., Yan, K., Paquet, E., Holliday, M., Saksouk, N., Joncas, F.-H., Glass, K.C., Avvakumov, N., Lalonde, M.-E., Genes and Development, 2013, 10.1101/gad.223396.113
  • Conserved molecular interactions within the HBO1 acetyltransferase complexes regulate cell proliferation, Côté, J., Kutateladze, T.G., Yang, X.-J., Richard, D.E., Robitaille, G.A., Cayrou, C., Doyon, Y., Landry, A.-J., Glass, K.C., Paquet, E., Saksouk, N., Lalonde, M.-E., Avvakumov, N., Molecular and Cellular Biology, 2012, 10.1128/MCB.06455-11
  • Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes, Jacques Cote, Cell Reports, 2022, 10.1016/j.celrep.2022.110947
  • MRG proteins are shared by multiple protein complexes with distinct functions., , Molecular & cellular proteomics : MCP, 2022, 10.1016/j.mcpro.2022.100253
  • The SWI/SNF complex creates loop domains in DNA and polynucleosome arrays and can disrupt DNA-histone contacts within these domains, Workman, J.L., Peterson, C.L., Landel, C.C., Côté, J., Bazett-Jones, D.P., Molecular and Cellular Biology, 1999, 10.1128/MCB.19.2.1470
  • Perturbation of nucleosome core structure by the SWI/SNF complex persists after its detachment, enhancing subsequent transcription factor binding, Workman, J.L., Peterson, C.L., Côté, J., Proceedings of the National Academy of Sciences of the United States of America, 1998, 10.1073/pnas.95.9.4947
  • Histone target selection within chromatin: An exemplary case of teamwork, Cheng, X., Côté, J., Lalonde, M.-E., Genes and Development, 2014, 10.1101/gad.236331.113
  • DNA repair: Chromatin remodeling without H2A.Z?, Côté, J., Jacquet, K., Cell Cycle, 2014, 10.4161/cc.28383
  • Eaf5/7/3 form a functionally independent NuA4 submodule linked to RNA polymerase II-coupled nucleosome recycling, Côté, J., Kobor, M. S., Nourani, A., Piquet, S., Monnet-Saksouk, J., Côté, V., Schulze, J. M., Lacoste, N., Steunou, A. L., Wang, A. Y., Cramet, M., Rossetto, D., EMBO J, 2014, 10.15252/embj.201386433
  • Preparation and Analysis of Native Chromatin-Modifying Complexes, Côté, J., Doyon, Y., Methods in Enzymology, 2016, 10.1016/bs.mie.2016.01.017
  • Bivalent interaction of the PZP domain of BRPF1 with the nucleosome impacts chromatin dynamics and acetylation, Kutateladze, T. G., Luger, K., Côté, J., Poirier, M. G., Kurumizaka, H., Yan, K., Machida, S., Hepler, M., Andrews, F. H., Gibson, M. D., Lalonde, M. E., Muthurajan, U. M., Klein, B. J., Nucleic Acids Res, 2016, 10.1093/nar/gkv1321
  • BRPF3-HBO1 regulates replication origin activation and histone H3K14 acetylation, Groth, A., Côté, J., Gingras, A. C., Yang, X. J., Paquet, E., Johansen, J. V., Alabert, C., Zhao, X., Lee, S. B., Lambert, J. P., González-Aguilera, C., Lalonde, M. E., Roques, C., Vlassis, A., Feng, Y., EMBO J, 2016, 10.15252/embj.201591293
  • Pre-existing H4K16ac levels in euchromatin drive DNA repair by homologous recombination in S-phase, Tej K. Pandita, Clayton R. Hunt, Biana Godin, Jacques Cote, Sharmistha Chakraborty, Puja Gaur Khaitan, Nobuko T. Horikoshi, Shashank Hambarde, Vijaya K. Charaka, Raj K. Pandita, Fransisca Leonard, Dharmendra Sharma, Nobuo Horikoshi, Communications Biology, 2019, 10.1038/s42003-019-0498-z
  • Phospho-dependent recruitment of the yeast NuA4 acetyltransferase complex by MRX at DNA breaks regulates RPA dynamics during resection, , PNAS, 2018, 10.1073/pnas.1806513115
  • Integrated analysis of H2A.Z isoforms function reveals a complex interplay in gene regulation, Didier Trouche, Jacques Côté, Estelle Nicolas, Xue Cheng, Marion Aguirrebengoa, Jonathan Humbert, Assala Lamaa, eLife, 2020, 10.7554/eLife.53375
  • The deubiquitylase Ubp15 couples transcription to mRNA export, François Robert, Jacques Côté, Célia Jeronimo, Fanny Eyboulet, eLife, 2020, 10.7554/eLife.61264
  • De Novo KAT5 Variants Cause a Syndrome with Recognizable Facial Dysmorphisms, Cerebellar Atrophy, Sleep Disturbance, and Epilepsy, , The American Journal of Human Genetics, 2020, 10.1016/j.ajhg.2020.08.002
  • New insights into the DNA repair pathway choice with NuA4/TIP60., , DNA repair, 2022, 10.1016/j.dnarep.2022.103315
  • Approaches to Study Native Chromatin-Modifying Complex Activities and Functions, , Frontiers in Cell and Developmental Biology, 2021, 10.3389/fcell.2021.729338
  • Recognition of (dG)n.(dC)n sequences by endonuclease G. Characterization of the calf thymus nuclease., Ruiz-Carrillo, A., Renaud, J., Côté, J., Journal of Biological Chemistry, 1989
  • Stimulation of transcription factor binding and histone displacement by nucleosome assembly protein 1 and nucleoplasmin requires disruption of the histone octamer, Workman, J.L., Côté, J., Owen-Hughes, T.A., Walter, P.P., Molecular and Cellular Biology, 1995, 10.1128/MCB.15.11.6178
  • [7] Experimental analysis of transcription factor-nucleosome interactions, Workman, J.L., Walter, P., Côté, J., Adams, C.C., Vettese-Dadey, M., Methods in Molecular Genetics, 1995, 10.1016/S1067-2389(06)80010-5
  • Purification and biochemical heterogeneity of the mammalian SWI-SNF complex, Crabtree, G.R., Workman, J.L., Yaniv, M., Goff, S.P., Kalpana, G.V., Muchardt, C., Biggar, S.R., Khavari, P.A., Zhou, S., Xue, Y., Côté, J., Wang, W., EMBO Journal, 1996
  • Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: Characterization of an ada complex and the saga (spt/ada) complex, Workman, J.L., Berger, S.L., Winston, F., Allis, C.D., Owen-Hughes, T., Ohba, R., Candau, R., Brownell, J.E., Roberts, S.M., Côté, J., Duggan, L., Grant, P.A., Genes and Development, 1997, 10.1101/gad.11.13.1640
  • Transcriptional activators direct histone acetyltransferase complexes to nucleosomes, Workman, J.L., John, S., Eberharter, A., Steger, D.J., Côté, J., Grant, P.A., Ikeda, K., Utley, R.T., Nature, 1998, 10.1038/28886
  • SWI/SNF stimulates the formation of disparate activator-nucleosome complexes but is partially redundant with cooperative binding, Workman, J.L., Owen-Hughes, T., Côté, J., Utley, R.T., Journal of Biological Chemistry, 1997, 10.1074/jbc.272.19.12642
  • MORF and MOZ acetyltransferases target unmethylated CpG islands through the winged helix domain., Tatiana Kutateladze, Akihiko Yokoyama, Jacques Cote, Poirier MG, Yawen Bai, Martha Bulyk, Amelie Fradet-Turcotte, Galloy M, Lachance C, CHRISTOPHER EBMEIER, Chen RW, Yi Zhang, Phanor SK, Bing-Rui Zhou, Cox KL, Jang SM, Akinori Kanai, Brianna Klein, Dustin C. Becht, Nature communications, 2023, 10.1038/s41467-023-36368-5
  • Characterization of multiple interactions between the envelope E protein of SARS-CoV-2 and human BRD4, Tatiana Kutateladze, Jacques Côté, Siddappa N. Byrareddy, Arpan Acharya, Catherine Lachance, Suk Min Jang, Mohamad Zandian, Jacques Cote, STAR Protocols, 2022, 10.1016/j.xpro.2022.101853
  • Recurrent chromosomal translocations in sarcomas create a megacomplex that mislocalizes NuA4/TIP60 to Polycomb target loci, Jacques Cote, Genes & Development, 2022, 10.1101/gad.348982.121
  • NuA4 and H2A.Z control environmental responses and autotrophic growth in Arabidopsis, Jacques Cote, Nature Communications, 2022, 10.1038/s41467-021-27882-5
  • Molecular Basis for the PZP Domain of BRPF1 Association with Chromatin, , Structure, 2020, 10.1016/j.str.2019.10.014
  • Gcn5 and Esa1 function as histone crotonyltransferases to regulate crotonylation-dependent transcription, Haico van Attikum, Peter A. van Veelen, Jacques Côté, Fabrizio Martino, Kees Vreeken, Xue Cheng, George M.C. Janssen, Anton J.L. de Groot, Leonie Kollenstart, Journal of Biological Chemistry, 2019, 10.1074/jbc.RA119.010302
  • Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation., , Nature communications, 2019, 10.1038/s41467-019-12551-5
  • Yaf9 subunit of the NuA4 and SWR1 complexes targets histone H3K27ac through its YEATS domain., , Nucl Acids Res, 2018, 10.1093/nar/gkx1151
  • Architecture of the Saccharomyces cerevisiae NuA4/TIP60 complex, Cai, G., Côté, J., Zhang, Z., Ahmad, S., Wang, X., Nature Communications, 2018, 10.1038/s41467-018-03504-5
  • Novel mechanism of PCNA control through acetylation of its sliding surface, Jacques Côté, Pierre Billon, Molecular & Cellular Oncology, 2017, 10.1080/23723556.2017.1279724
  • Acetylation of PCNA Sliding Surface by Eco1 Promotes Genome Stability through Homologous Recombination, Côté, J., Couture, J.-F., Sugiyama, T., Verreault, A., Gingras, A.-C., Brunzelle, J.S., Tremblay, V., Chen, Y., Lambert, J.-P., Li, J., Billon, P., Molecular Cell, 2017, 10.1016/j.molcel.2016.10.033
  • Purification of yeast native reagents for the analysis of chromatin function-I: Nucleosomes for reconstitution and manipulation of histone marks, Côté, J., Bhat, W., Lacoste, N., Methods in Molecular Biology, 2017, 10.1007/978-1-4939-6630-1_3
  • Purification of yeast native reagents for the analysis of chromatin function-II: Multiprotein complexes and biochemical assays, Côté, J., Bhat, W., Lacoste, N., Methods in Molecular Biology, 2017, 10.1007/978-1-4939-6630-1_4
  • Combined action of histone reader modules regulates NuA4 local acetyltransferase function but not its recruitment on the genome, Côté, J., Kobor, M.S., Robert, F., Krogan, N., Utley, R.T., Paquet, E., Côté, V., Drouin, S., Lacoste, N., Aristizabal, M.J., Rossetto, D., Cramet, M., Steunou, A.-L., Molecular and Cellular Biology, 2016, 10.1128/MCB.00112-16
  • Eaf1 Links the NuA4 Histone Acetyltransferase Complex to Htz1 Incorporation and Regulation of Purine Biosynthesis, Côté, J., Robert, F., Utley, R. T., Paquet, E., Drouin, S., Altaf, M., Auger, A., Cheng, X., Eukaryot Cell, 2015, 10.1128/EC.00004-15
  • TINTIN, at the interface of chromatin, transcription elongation, and mRNA processing, Côté, J., Ahmad, S., Bhat, W., RNA Biol, 2015, 10.1080/15476286.2015.1026032
  • Crosstalk between epigenetic readers regulates the MOZ/MORF HAT complexes, Kutateladze, T.G., Yang, X.-J., Côté, J., Lalonde, M.-E., Klein, B.J., Epigenetics, 2014, 10.4161/epi.26792
  • MChIP-KAT-MS, a method to map protein interactions and acetylation sites for lysine acetyltransferases, Baetz, K., Figeys, D.A., Côté, J., Basu, A., Ning, Z., Zhou, H., Lambert, J.-P., Hamza, A., Steunou, A.-L., Pourhanifeh-Lemeri, R., Cotrut, M., Huard, S., Mitchell, L., Proceedings of the National Academy of Sciences of the United States of America, 2013, 10.1073/pnas.1218515110
  • A Chromatin Switch for Chromosome Condensation, Côté, J., Bilodeau, S., Developmental Cell, 2012, 10.1016/j.devcel.2012.11.016
  • MYST protein acetyltransferase activity requires active site lysine autoacetylation, Marmorstein, R., Côté, J., McMahon, S.B., Sternglanz, R., Berger, S.L., Johnson, F.B., Verreault, A., Thibault, P., Speicher, D.W., Yang, C., Zheng, Y.G., Wu, J., Perry, R., Abshiru, N., Speicher, K., Ding, E.C., Hodawadekar, S., Johnson, J., Srinivasan, M., Dang, W., Mellert, H., Rossetto, D., Yuan, H., EMBO Journal, 2012, 10.1038/emboj.2011.382
  • Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1, Kutateladze, T.G., Côté, J., Yasui, A., Kulesza, C.A., Nickoloff, J., Nuñez, J.K., Roy, S., Allen, C., Hong, Z., Lalonde, M.-E., Abraham, C.G., Watanabe, R., Avvakumov, N., Musselman, C.A., Nature Structural and Molecular Biology, 2012, 10.1038/nsmb.2435
  • Precise deposition of histone H2A.Z in chromatin for genome expression and maintenance, Côté, J., Billon, P., Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, 2012, 10.1016/j.bbagrm.2011.10.004
  • Histone Chaperones: Modulators of Chromatin Marks, Côté, J., Nourani, A., Avvakumov, N., Molecular Cell, 2011, 10.1016/j.molcel.2011.02.013
  • MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair, Pandita, T.K., Cote, J., Chen, D.J., Porteus, M.H., Pandita, R.K., Bhadra, U., Avvakumov, N., Cayrou, C., Kumar, R., Gupta, A., So, S., Sharma, G.G., Molecular and Cellular Biology, 2010, 10.1128/MCB.01476-09
  • Connection between histone H2A variants and chromatin remodeling complexes, Côté, J., Covic, M., Auger, A., Altaf, M., Biochemistry and Cell Biology, 2009, 10.1139/O08-140
  • (de)MYSTification and INGenuity of tumor suppressors, Côté, J., Avvakumov, N., Saksouk, N., Cellular and Molecular Life Sciences, 2008, 10.1007/s00018-008-7459-x
  • Eaf1 Is the platform for NuA4 molecular assembly that evolutionarily links chromatin acetylation to ATP-dependent exchange of histone H2A variants, Côté, J., Allard, S., Cronier, D., Utley, R.T., Doyon, Y., Nourani, A., Altaf, M., Galarneau, L., Auger, A., Molecular and Cellular Biology, 2008, 10.1128/MCB.01755-07
  • The crystal structure of the ING5 PHD finger in complex with an H3K4me3 histone peptide, Kutateladze, T.G., Côté, J., Yang, X.-J., Ullah, M., Johnson, K., Peña, P.V., Saksouk, N., Champagne, K.S., Proteins: Structure, Function and Genetics, 2008, 10.1002/prot.22140
  • Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9, Kron, S.J., Côté, J., Sha, F., Allard, S., Javaheri, A., Wysocki, R., Molecular and Cellular Biology, 2005, 10.1128/MCB.25.19.8430-8443.2005
  • The Saccharomyces cerevisiae Piccolo NuA4 histone acetyltransferase complex requires the enhancer of polycomb A domain and chromodomain to acetylate nucleosomes, Tan, S., Côté, J., Sermwittayawong, D., Fortin, I., Selleck, W., Molecular and Cellular Biology, 2005, 10.1128/MCB.25.13.5535-5542.2005
  • The Yaf9 component of the SWR1 and NuA4 complexes is required for proper gene expression, histone H4 acetylation, and Htz1 replacement near telomeres, Cairns, B.R., Côté, J., Tempst, P., Erdjument-Bromage, H., Utley, R., Roberts, D.N., Richardson, D.O., Zhang, H., Molecular and Cellular Biology, 2004, 10.1128/MCB.24.21.9424-9436.2004
  • The MYST family of histone acetyltransferases, Côté, J., Utley, R.T., Current Topics in Microbiology and Immunology, 2003
  • The epigenetic code of histones | Le code épigénétique des histones, Côté, J., Lacoste, N., Medecine/Sciences, 2003, 10.1051/medsci/20031910955
  • The histone variant macroH2A interferes with transcription factor binding and SWI/SNF nucleosome remodeling, Dimitrov, S., Bouvet, P., Khochbin, S., Côté, J., Hans, F., Perche, P.-Y., Molla, A., Angelov, D., Molecular Cell, 2003, 10.1016/S1097-2765(03)00100-X
  • Role of an ING1 growth regulator in transcriptional activation and targeted histone acetylation by the NuA4 complex, Côté, J., Lane, W.S., Allard, S., Utley, R.T., Doyon, Y., Nourani, A., Molecular and Cellular Biology, 2001, 10.1128/MCB.21.22.7629-7640.2001
  • A novel H2A/H4 nucleosomal histone acetyltransferase in Tetrahymena thermophila, Allis, C.D., Workman, J.L., Côté, J., Cook, R.G., Mizzen, C.A., Brownell, J.E., Steger, D.J., Ohba, R., Molecular and Cellular Biology, 1999

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Amel Mameri - Maîtrise avec mémoire - En cours
  • Vasilisa Pozharskaia - Post-doctorat - En cours
  • Golareh Asgaritarghi - Doctorat - En cours
  • Deepthi Sudarshan - Doctorat - En cours
  • Juan Carlos Yustis Rubio - Doctorat - En cours
  • Ke Xu - Doctorat - En cours
  • Erell Cadoret - Doctorat - En cours
  • Emile Clerf - Doctorat - En cours
  • Marie-Eve Lalonde - Doctorat - 2014/05
  • Xue Cheng - Maîtrise avec mémoire - 2014/09
  • Pierre Billon - Doctorat - 2015/09
  • Karine Jacquet - Doctorat - 2016/05
  • Ibrahim Alharbi - Doctorat - 2020/01
  • Salar Ahmad - Doctorat - 2021/05
  • Maeva Devoucoux - Doctorat - 2021/09
  • Jonathan Humbert - Doctorat - 2022/09

Encadrement d'étudiant(e)s pour les programmes suivants :

*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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