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Girish M. Shah

Professeur titulaire

Girish M. Shah
girish-m.shah@fmed.ulaval.ca
Centre de recherche sur le cancer
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Médecine régénératrice et médecine moléculaire
Neurosciences et santé mentale
Oncologie

Domaines et intérêts de recherche du (de la) professeur(e) :

Cancer
  • Apoptose et cancer
  • Cancer de la peau
  • Cancer de l'appareil digestif
  • Carcinogénèse
  • Chimiothérapie
  • Diagnostic et détection du cancer
  • Environnement et cancer
  • Interaction hôte - tumeur
  • Oncogènes
  • Radiothérapie
Neurosciences, santé mentale et toxicomanies
  • Apoptose
  • Maladies neuroendocriniennes
Génomique et protéomique
  • Mécanismes biologiques et biochimiques
Organisation et fonctions biologiques

Projets de recherche

  • Roles of poly (ADP-ribose) polymerase-1 in mammalian transcription-coupled nucleotide excision repair of DNA damage - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2022-04-01 au 2027-03-31
  • Screening of gastroenteropancreatic neuroendocrine tumors from patients for temozolomide-induced upregulation of SSTR2: Towards improved PRRT - Société des tumeurs Carcinoïdes-NeuroEndocrines du Canada, chercheur principal - 2023-04-01 au 2025-12-31
  • Potentiation of PRRT by chemotherapy-mediated upregulation of somatostatin receptor 2 in NET cell lines-derived tumors in mice and in Lung NET patient-derived tumor explants - Société des tumeurs Carcinoïdes-NeuroEndocrines du Canada, chercheur principal - 2022-04-01 au 2024-12-31
  • Équipement de laboratoire radiopharmaceutique pour la théranostique et l'imagerie moléculaire innovantes - Ministère de la Santé et des Services sociaux, Fondation du CHU de Québec, Fondation Canadienne pour l'innovation (La) - Fonds des leaders John-R.-Evans (FLJR), co-chercheur - 2022-07-01 au 2023-12-15
  • Chemotherapy-induced upregulation of somatostatin receptors for enhancing therapeutic efficacy of, and eligibility to PRRT of neuroendocrine tumors - Société des tumeurs Carcinoïdes-NeuroEndocrines du Canada, chercheur principal - 2020-07-01 au 2022-12-31

Publications

  • Suppression of oxidative-stress induced melanocyte death: Role of poly(ADP-ribose) polymerase in vitiligo pathogenesis, , Indian journal of dermatology, venereology and leprology, 2022, 10.25259/IJDVL_290_2021
  • The balance between Cu,Zn-superoxide dismutase and catalase affects the sensitivity of mouse epidermal cells to oxidative stress, , Biochemistry, 1991, 10.1021/bi00102a024
  • Mechanisms of oxidant carcinogenesis, , Progress in clinical and biological research, 1990
  • Poly(ADP-ribose) catabolism in mammalian cells, , Molecular and cellular biochemistry, 1994, 10.1007/BF00928442
  • Pharmacological intakes of niacin increase bone marrow poly(ADP-ribose) and the latency of ethylnitrosourea-induced carcinogenesis in rats, , The Journal of nutrition, 2002, 10.1093/jn/132.1.115
  • Approaches to detect PARP-1 activation in vivo, in situ, and in vitro, , Methods in molecular biology (Clifton, N.J.), 2011, 10.1007/978-1-61779-270-0_1
  • New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis, , The Journal of biological chemistry, 1996, 10.1074/jbc.271.46.29073
  • Mechanism of early biphasic activation of poly(ADP-ribose) polymerase-1 in response to ultraviolet B radiation, , Journal of cell science, 2005, 10.1242/jcs.01636
  • Resistance to PARP-Inhibitors in Cancer Therapy, , Frontiers in pharmacology, 2013, 10.3389/fphar.2013.00018
  • Enhanced Dark-Field Hyperspectral Imaging and Spectral Angle Mapping for Nanomaterial Detection in Consumer Care Products and in Skin Following Dermal Exposure, , Chemical research in toxicology, 2020, 10.1021/acs.chemrestox.0c00090
  • Poly(ADP-ribose) polymerase 1 is inhibited by a histone H2A variant, MacroH2A, and contributes to silencing of the inactive X chromosome, , The Journal of biological chemistry, 2007, 10.1074/jbc.M610502200
  • Detection of poly(ADP-ribose) polymerase and its apoptosis-specific fragment by a nonisotopic activity-western blot technique, , Analytical biochemistry, 1995, 10.1006/abio.1995.0016
  • Modulation of transcription in rat liver nuclei in vitro by a diol epoxide of benzo a pyrene, , Journal of biochemical toxicology, 1992, 10.1002/jbt.2570070104
  • XPC–PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair, Martijn Luijsterburg, Andreas Ladurner, Haico van Attikum, Hannes Lans, Sheera Adar, Girish Shah, Alfred C. O. Vertegaal, Orlando D. Schärer, Hyun-Suk Kim, Angela Kragten, Jin Cai, Daphne E. C. Boer, Tia Tyrsett Kuo, Rashmi G. Shah, Avital Parnas, Adi Yifrach, Román González-Prieto, Melanie van der Woude, Magdalena B. Rother, Claudia Gonzalez-Leal, Diana van den Heuvel, Katja Apelt, Charlotte Blessing, Nature Communications, 2022, 10.1038/s41467-022-31820-4
  • Biochemical properties and function of poly(ADP-ribose) glycohydrolase, , Biochimie, 1995, 10.1016/0300-9084(96)88156-9
  • Modulation of transcription in rat liver by benzo a pyrene, , Cancer letters, 1987, 10.1016/0304-3835(87)90044-9
  • Defective control of mitotic and post-mitotic checkpoints in poly(ADP-ribose) polymerase-1(-/-) fibroblasts after mitotic spindle disruption, , Cell cycle (Georgetown, Tex.), 2004
  • Inhibition of L-ascorbate of binding to DNA of benzo(a)pyrene & its metabolites, , Indian journal of biochemistry & biophysics, 1980
  • 6-Aminonicotinamide sensitizes human tumor cell lines to cisplatin, , Clinical cancer research : an official journal of the American Association for Cancer Research, 1998
  • Modulation by plant flavonoids and related phenolics of microsome catalyzed adduct formation between benzo a pyrene and DNA, , Chemico-biological interactions, 1986, 10.1016/s0009-2797(86)80051-5
  • A panel of criteria for comprehensive assessment of severity of ultraviolet B radiation-induced non-melanoma skin cancers in SKH-1 mice, , Journal of photochemistry and photobiology. B, Biology, 2020, 10.1016/j.jphotobiol.2020.111847
  • Abrogation of DNA vector-based RNAi during apoptosis in mammalian cells due to caspase-mediated cleavage and inactivation of Dicer-1, , Cell death and differentiation, 2009, 10.1038/cdd.2009.15
  • Granzyme B/perforin-mediated apoptosis of Jurkat cells results in cleavage of poly(ADP-ribose) polymerase to the 89-kDa apoptotic fragment and less abundant 64-kDa fragment, , Biochemical and biophysical research communications, 1996, 10.1006/bbrc.1996.1565
  • SAPK2/p38-dependent F-actin reorganization regulates early membrane blebbing during stress-induced apoptosis, , The Journal of cell biology, 1998, 10.1083/jcb.143.5.1361
  • Pharmacological inhibition of poly(ADP-ribose) polymerase (PARP) activity in PARP-1 silenced tumour cells increases chemosensitivity to temozolomide and to a N3-adenine selective methylating agent, , Current cancer drug targets, 2010, 10.2174/156800910791208571
  • Cleavage of poly(ADP-ribose) polymerase: a sensitive parameter to study cell death, , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1997
  • Chemotherapy-Induced Upregulation of Somatostatin Receptor-2 Increases the Uptake and Efficacy of Lu-DOTA-Octreotate in Neuroendocrine Tumor Cells, , Cancers, 2021, 10.3390/cancers13020232
  • Niacin deficiency increases the sensitivity of rats to the short and long term effects of ethylnitrosourea treatment, , Molecular and cellular biochemistry, 1999
  • Poly(ADP-ribosyl)ation temporally confines SUMO-dependent ataxin-3 recruitment to control DNA double-strand break repair, , Journal of cell science, 2021, 10.1242/jcs.247809
  • Niacin deficiency decreases bone marrow poly(ADP-ribose) and the latency of ethylnitrosourea-induced carcinogenesis in rats, , The Journal of nutrition, 2002, 10.1093/jn/132.1.108
  • Role of poly(ADP-ribose) polymerase in rapid intracellular acidification induced by alkylating DNA damage, , Proceedings of the National Academy of Sciences of the United States of America, 2002, 10.1073/pnas.012460399
  • Regulation of poly(ADP-ribose) polymerase-1 functions by leukocyte elastase inhibitor/LEI-derived DNase II during caspase-independent apoptosis, , The international journal of biochemistry & cell biology, 2009, 10.1016/j.biocel.2008.09.026
  • Biochemical assessment of niacin deficiency among carcinoid cancer patients, , The American journal of gastroenterology, 2005, 10.1111/j.1572-0241.2005.00268.x
  • Erasable blot of poly(ADP-ribose) polymerase, , Analytical biochemistry, 1994, 10.1006/abio.1994.1212
  • Poly(ADP-ribose) polymerase 1 escorts XPC to UV-induced DNA lesions during nucleotide excision repair, , Proceedings of the National Academy of Sciences of the United States of America, 2017, 10.1073/pnas.1706981114
  • In vivo effect of L-ascorbic acid on benzo(α)pyrene metabolite-DNA adduct formation in rat liver, , Journal of biosciences, 1982, 10.1007/BF02702737
  • Purification of poly(ADP-ribose) glycohydrolase and detection of its isoforms by a zymogram following one- or two-dimensional electrophoresis, , Analytical biochemistry, 1994, 10.1006/abio.1994.1177
  • Oxidant carcinogenesis and antioxidant defense, , Annals of the New York Academy of Sciences, 1992, 10.1111/j.1749-6632.1992.tb38659.x
  • PARP Inhibitors in Cancer Therapy: Magic Bullets but Moving Targets, , Frontiers in oncology, 2013, 10.3389/fonc.2013.00279
  • Specific cleavage of the large subunit of replication factor C in apoptosis is mediated by CPP32-like protease, , Biochemical and biophysical research communications, 1997, 10.1006/bbrc.1997.6456
  • Poly (ADP-ribose) polymerase (PARP) inhibition in cancer: Potential impact in cancer stem cells and therapeutic implications, , European journal of pharmacology, 2021, 10.1016/j.ejphar.2021.174546
  • Comprehensive measurement of UVB-induced non-melanoma skin cancer burden in mice using photographic images as a substitute for the caliper method, , PloS one, 2017, 10.1371/journal.pone.0171875
  • The effect of some new platinum (II) and palladium (II) coordination complexes on rat hepatic nuclear transcription in vitro, , Life sciences, 1992, 10.1016/0024-3205(92)90183-p
  • Rapid removal of nonspecific background in silver-stained polyacrylamide gel, , Analytical biochemistry, 1995, 10.1006/abio.1995.9947
  • Persistence of different forms of transient RNAi during apoptosis in mammalian cells, , PloS one, 2010, 10.1371/journal.pone.0012263
  • DNA vector-based RNAi approach for stable depletion of poly(ADP-ribose) polymerase-1, , Biochemical and biophysical research communications, 2005, 10.1016/j.bbrc.2005.03.135
  • Mode of action of poly(ADP-ribose) glycohydrolase, , Biochimica et biophysica acta, 1994, 10.1016/0167-4781(94)90058-2
  • Common fragile sites in colon cancer cell lines: role of mismatch repair, RAD51 and poly(ADP-ribose) polymerase-1, , Mutation research, 2011, 10.1016/j.mrfmmm.2011.04.006
  • Methods for biochemical study of poly(ADP-ribose) metabolism in vitro and in vivo, , Analytical biochemistry, 1995, 10.1006/abio.1995.1245
  • Swertisin an Anti-Diabetic Compound Facilitate Islet Neogenesis from Pancreatic Stem/Progenitor Cells via p-38 MAP Kinase-SMAD Pathway: An In-Vitro and In-Vivo Study, , PloS one, 2015, 10.1371/journal.pone.0128244
  • Stable depletion of poly (ADP-ribose) polymerase-1 reduces in vivo melanoma growth and increases chemosensitivity, , European journal of cancer (Oxford, England : 1990), 2008, 10.1016/j.ejca.2008.03.019
  • Niacin deficiency in rats increases the severity of ethylnitrosourea-induced anemia and leukopenia, , The Journal of nutrition, 2000, 10.1093/jn/130.5.1102
  • Alteration in hepatic nuclear RNA polymerase activity following benzo a pyrene administration in rat, , In vivo (Athens, Greece), 1989
  • Cellular responses to DNA damage in the absence of Poly(ADP-ribose) polymerase, , Biochemical and biophysical research communications, 1998, 10.1006/bbrc.1998.8257
  • Loss of ZBTB24 impairs nonhomologous end-joining and class-switch recombination in patients with ICF syndrome, , The Journal of experimental medicine, 2020, 10.1084/jem.20191688
  • Inhibition of rat hepatic nuclear RNA synthesis in vivo and in vitro by benzo a pyrene, , Polycyclic aromatic compounds, 1993
  • Deubiquitinating enzymes and the proteasome regulate preferential sets of ubiquitin substrates, , Nature communications, 2022, 10.1038/s41467-022-30376-7
  • Role of poly(ADP-ribose) polymerase-1 in the removal of UV-induced DNA lesions by nucleotide excision repair, , Proceedings of the National Academy of Sciences of the United States of America, 2013, 10.1073/pnas.1209507110
  • Inhibition of homologous recombination by treatment with BVDU (brivudin) or by RAD51 silencing increases chromosomal damage induced by bleomycin in mismatch repair-deficient tumour cells, , Mutation research, 2009, 10.1016/j.mrfmmm.2009.02.005
  • Methods to Study Intracellular Movement and Localization of the Nucleotide Excision Repair Proteins at the DNA Lesions in Mammalian Cells, , Frontiers in cell and developmental biology, 2020, 10.3389/fcell.2020.590242
  • Mechanism of induction of c-fos by ultraviolet B (290-320 nm) in mouse JB6 epidermal cells, , Cancer research, 1993
  • Combination treatments to enhance peptide receptor radionuclide therapy of neuroendocrine tumours, , European journal of nuclear medicine and molecular imaging, 2020, 10.1007/s00259-019-04499-x
  • Survival and proliferation of cells expressing caspase-uncleavable Poly(ADP-ribose) polymerase in response to death-inducing DNA damage by an alkylating agent, , The Journal of biological chemistry, 1999, 10.1074/jbc.274.52.37097
  • Characterization of anti-peptide antibodies directed towards the automodification domain and apoptotic fragment of poly (ADP-ribose) polymerase, , Biochimica et biophysica acta, 1997, 10.1016/s0304-4165(96)00077-3
  • Depletion of poly(ADP-ribose) polymerase-1 reduces host cell reactivation of a UV-damaged adenovirus-encoded reporter gene in human dermal fibroblasts, , DNA repair, 2008, 10.1016/j.dnarep.2008.01.001
  • Complete inhibition of poly(ADP-ribose) polymerase activity prevents the recovery of C3H10T1/2 cells from oxidative stress, , Biochimica et biophysica acta, 1996, 10.1016/0167-4889(96)00004-3
  • Characterization of the interactions of PARP-1 with UV-damaged DNA in vivo and in vitro, , Scientific reports, 2016, 10.1038/srep19020
  • Different cleavage pattern for poly(ADP-ribose) polymerase during necrosis and apoptosis in HL-60 cells, , Biochemical and biophysical research communications, 1996, 10.1006/bbrc.1996.1889
  • Action of some retinol derivatives and their provitamins on microsome-catalyzed formation of benzo a pyrene-DNA adduct, , Journal of biochemical toxicology, 1992, 10.1002/jbt.2570070307
  • PARP1 Links CHD2-Mediated Chromatin Expansion and H3.3 Deposition to DNA Repair by Non-homologous End-Joining, , Molecular cell, 2016, 10.1016/j.molcel.2016.01.019
  • Potentiation of Lu-octreotate peptide receptor radionuclide therapy of human neuroendocrine tumor cells by PARP inhibitor, , Oncotarget, 2018, 10.18632/oncotarget.25266

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Marine Merlin - Doctorat - En cours
  • Nancy Petitclerc - Maîtrise avec mémoire - 2012/05
  • Mihaela Robu - Doctorat - 2017/05
  • Nupur Purohit - Doctorat - 2020/05
  • Samuel Adant - Maîtrise avec mémoire - 2021/09

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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