Découvrez nos professeurs et professeures!
François Bordeleau
Professeur agrégé
Centre de recherche sur le cancer
Centre de recherche du CHU de Québec - Université Laval
Centre de recherche en organogenèse expérimentale
Contribution à la recherche
Thématiques de recherche de la Faculté de médecine
- Oncologie
- Bioinformatique / données massives (big data)
- Médecine régénératrice et médecine moléculaire
Domaines de recherche
- Génie médical et biomédical, n.c.a.
- Métastases et progression du cancer
- Génie des tissus artificiels
- Génétique quantitative (y compris la cartographie génétique des maladies et des caractères)
- Physique atomique, moléculaire et optique, n.c.a.
- Nanobiotechnologies
- Études sur le cytosquelette
- Interactions cellulaires (y compris l'adhérence, la matrice et la paroi cellulaire)
- Biotechnologies médicales, n.c.a.
- Signalisation intracellulaire, transduction des signaux, biologie des récepteurs et des membranes
- Diagnostics faisant appel aux biotechnologies médicales (y compris les biocapteurs)
- Biologie cellulaire computationnelle
- Médecine régénérative (y compris les cellules souches et le génie tissulaire)
- Génomique
- Tumeurs cancéreuses solides
Projets de recherche en cours
- Protein glycation acts as a substrate-dependent tumorigenic molecular switch in prostate cancer - Instituts de recherche en santé du Canada - Subvention Projet, Institut de recherche du Centre universitaire de santé McGill, co-chercheur - 2022-04-01 au 2027-03-31
- Validation d’une signature d’épissage alternatif mécano-dépendante pour prédire de manière précoce les risques de progression du cancer du sein vers un stade métastatique - Fondation du CHU de Québec - Excellence en recherche - Projets d'envergure, chercheur principal - 2025-03-01 au 2027-03-31
- Creating a biomimetic 3D engineered model of the liver metastatic niche - Secrétariat des programmes interorganismes à l’intention des établissements - Nouvelles frontières en recherche, chercheur principal - 2024-03-31 au 2026-03-30
- Canada Research Chair in Tumor Mechanoregulation - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2020-07-01 au 2025-06-30
...
Financements des 2 dernières années
- Mise en place de la plateforme d'ingénierie tissulaire en cancer - Fondation Canadienne pour l'innovation (La), Ministère de la Santé et des Services sociaux, Advanced Solutions - Fonds d'innovation (FI), chercheur principal - 2023-07-01 au 2025-03-31
- Programme de soutien aux nouveaux détenteurs de CRC - Université Laval - Fonds internes - Fonds de soutien aux professeurs-chercheurs bénéficiant d’une Chaire de recherche du Canada, chercheur principal - 2022-05-01 au 2024-04-30
- Hepatic stellate cells as a driver of the pre-metastatic niche in uveal melanoma - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2023-03-01 au 2024-02-29
- The combined role of cellular force dynamics and extracellular matrix mechanical properties in driving angiogenesis - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2018-04-01 au 2023-03-31
...
Publications
- Matrix stiffness regulates microvesicle-induced fibroblast activation, Reinhart-King, C.A., Cerione, R.A., Antonyak, M.A., Zhang, J., Bordeleau, F., Schwager, S.C., American Journal of Physiology - Cell Physiology, 2019, 10.1152/ajpcell.00418.2018
- Vinculin regulates directionality and cell polarity in two-And three-dimensional matrix and three-dimensional microtrack migration, Reinhart-King, C.A., García, A.J., Lin, D.Y., Lampi, M.C., Bordeleau, F., Goldblatt, Z.E., Kraning-Rush, C.M., Carey, S.P., Rahman, A., Molecular Biology of the Cell, 2016, 10.1091/mbc.E15-06-0432
- Using Machine Learning to Predict TP53 Mutation Status and Aggressiveness of Prostate Cancer from Routine Histology Images, François Bordeleau, Cancer Research, 2023, 10.1158/0008-5472.CAN-23-1856
- Physical biology in cancer. 5. The rocky road of metastasis: The role of cytoskeletal mechanics in cell migratory response to 3D matrix topography, Reinhart-King, C.A., Alcoser, T.A., Bordeleau, F., American Journal of Physiology - Cell Physiology, 2014, 10.1152/ajpcell.00283.2013
- Matrix stiffness enhances cancer-macrophage interactions and M2-like macrophage accumulation in the breast tumor microenvironment, Reinhart-King, C.A., Bordeleau, F., Hassane, D.C., Lau, K.S., King, M.R., Greenlee, J.D., Chen, B., Southard-Smith, A.N., Simmons, A.J., Wang, W., Taufalele, P.V., Acta Biomaterialia, 2023, 10.1016/j.actbio.2022.04.031
- Intermediate Filaments, Bordeleau, F., Gilbert, S., Loranger, A., Marceau, N., Cellular Domains, 2011, 10.1002/9781118015759.ch16
- Vascular smooth muscle cell matrix-degradation by podosomes, Reinhart-King, C.A., Bordeleau, F., Kohn, J.C., Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC, 2013, 10.1109/NEBEC.2013.151
- Matrix stiffening promotes a tumor vasculature phenotype, Reinhart-King, C.A., Weiss, R.S., Butcher, J.T., Bonassar, L.J., Hassane, D.C., Abril, Y.L.N., Mencia-Trinchant, N., Huynh, J., LaValley, D.J., Montague, C., Califano, J.P., Somasegar, S., Zanotelli, M.R., Mazzola, M., Lollis, E.M., Mason, B.N., Bordeleau, F., Proceedings of the National Academy of Sciences of the United States of America, 2017, 10.1073/pnas.1613855114
- Tuning cell migration: Contractility as an integrator of intracellular signals from multiple cues [version 1; referees: 2 approved], Reinhart-King, C.A., Bordeleau, F., F1000Research, 2016, 10.12688/F1000RESEARCH.7884.1
- Adenoviral protein E4orf4 interacts with the polarity protein par3 to induce nuclear rupture and tumor cell death, Lavoie, J.N., Huot, M.-É., Bordeleau, F., Richard, D.E., Laprise, P., Lambert, H., Fuchs, M., Bergeman, J., Boulanger, M.-C., Jacquet, K., Caillier, A., Rodrigue, M.-A., Dziengelewski, C., Journal of Cell Biology, 2020, 10.1083/JCB.201805122
- Targeted inhibition of fascin function blocks tumour invasion and metastatic colonization, Huang, X.-Y., Zhang, J.J., Reinhart-King, C.A., Bordeleau, F., Liu, B., Huang, J., Xing, B., Han, S., Huang, F.-K., Nature Communications, 2015, 10.1038/ncomms8465
- Energetic regulation of coordinated leader–follower dynamics during collective invasion of breast cancer cells, Reinhart-King, C.A., Bordeleau, F., Taufalele, P.V., Wang, W., Goliwas, K.F., Zhang, J., Proceedings of the National Academy of Sciences of the United States of America, 2019, 10.1073/pnas.1809964116
- Topographical guidance of 3D tumor cell migration at an interface of collagen densities, Reinhart-King, C.A., Tang, L.N., Bordeleau, F., Physical Biology, 2013, 10.1088/1478-3975/10/6/065004
- Microvesicles released from tumor cells disrupt epithelial cell morphology and contractility, Reinhart-King, C.A., Cerione, R.A., Lampi, M.C., Antonyak, M.A., Chan, B., Bordeleau, F., Journal of Biomechanics, 2016, 10.1016/j.jbiomech.2015.10.003
- Quantitative assessment of cell contractility using polarized light microscopy, Francois Bordeleau, Cynthia A. Reinhart‐King, Susan C. Pannullo, Joseph P. Miller, Wenjun Wang, Journal of Biophotonics, 2018, 10.1002/jbio.201800008
- Cancer-Associated Fibroblasts in a 3D Engineered Tissue Model Induce Tumor-like Matrix Stiffening and EMT Transition, François Bordeleau, Stéphane Bolduc, Frédéric Pouliot, Marc-Étienne Huot, Stéphane Chabaud, Geneviève Bernard, Cassandra Ringuette Goulet, Enola Bollmann, Martial Millet, Cancers, 2022, 10.3390/cancers14153810
- Extent of Cell Confinement in Microtracks Affects Speed and Results in Differential Matrix Strains, Cynthia A. Reinhart-King, Brenton D. Hoffman, Francois Bordeleau, Jacob A. VanderBurgh, Matthew R. Zanotelli, Aniqua Rahman-Zaman, Jenna A. Mosier, Biophysical Journal, 2019, 10.1016/j.bpj.2019.09.024
- High type I collagen density fails to increase breast cancer stem cell phenotype, Vanessa M. Freitas, Cynthia A. Reinhart-King, Murilo V. Geraldo, Karen S.C. Borbely, Luciana M. Dzik, François Bordeleau, Ana Carolina L. Ralph, Iuri C. Valadão, PeerJ, 2020, 10.7717/peerj.9153
- Probing the Biophysical Properties of Primary Breast Tumor-Derived Fibroblasts, Reinhart-King, C.A., Shin, S.J., Varma, S., Somasegar, S., Kowal, D.R., Lampi, M.C., Carey, S.P., Bordeleau, F., Alcoser, T.A., Cellular and Molecular Bioengineering, 2015, 10.1007/s12195-014-0360-9
- Measuring integrated cellular mechanical stress response at focal adhesions by optical tweezers, Shenga, Y., Marceau, N., Bessard, J., Bordeleau, F., Journal of Biomedical Optics, 2011, 10.1117/1.3626864
- Weakly migratory metastatic breast cancer cells activate fibroblasts via microvesicle-Tg2 to facilitate dissemination and metastasis, Reinhart-King, C.A., Cerione, R.A., Antonyak, M.A., Bordeleau, F., Bates, M.E., Jayathilake, A.L., Schunk, C., Wang, W., Mosier, J.A., McArdle, T.J., Carlson, C.M., Hapach, L.A., Young, K.M., Schwager, S.C., eLife, 2022, 10.7554/ELIFE.74433
- Weakly migratory metastatic breast cancer cells activate fibroblasts via microvesicle-Tg2 to facilitate dissemination and metastasis, Cynthia A. Reinhart-King, Richard A. Cerione, Marc A. Antonyak, Francois Bordeleau, Anissa L. Jayathilake, Wenjun Wang, Tanner J. McArdle, Jenna A. Mosier, Caroline M. Carlson, Lauren A. Hapach, Samantha C. Schwager, 2021, 10.1101/2021.10.27.466095
- Antigen detection at atomolar concentration using an optical tweezers, Sheng, Y., Marceau, N., Bordeleau, F., Laliberté, M., Proceedings of SPIE - The International Society for Optical Engineering, 2009, 10.1117/12.839769
- Subcellular regulation of cancer cell mechanics, Reinhart-King, C.A., Bordeleau, F., Zanotelli, M.R., Current Opinion in Biomedical Engineering, 2017, 10.1016/j.cobme.2017.02.001
- Coordination of non-professional efferocytosis and actomyosin contractility during epithelial tissue morphogenesis, Bouchard, M., Khadra, A., Bordeleau, F., Côté, J.-F., Tran, V., Schindler, M., Homsy, K., Luthold, C., Graham-Paquin, A.-L., Ponsin, K., Tang, Y.C., Cell Reports, 2023, 10.1016/j.celrep.2023.112202
- Chaperone-Assisted Mitotic Actin Remodeling by BAG3 and HSPB8 Involves the Deacetylase HDAC6 and Its Substrate Cortactin, Josée N. Lavoie, François Bordeleau, Herman Lambert, Alice-Anaïs Varlet, Carole Luthold, International Journal of Molecular Sciences, 2020, 10.3390/ijms22010142
- Synergic Interactions Between Hepatic Stellate Cells and Uveal Melanoma in Metastatic Growth, Solange Landreville, François Bordeleau, Peter R. A. Gerges, Julie Bérubé, Martial Millet, Nathan Schoonjans, Louise Dewit, Léo Piquet, Cancers, 2019, 10.3390/cancers11081043
- Simvastatin ameliorates matrix stiffness-mediated endothelial monolayer disruption, Reinhart-King, C.A., Zanotelli, M.R., Bordeleau, F., Huynh, J., Faber, C.J., Lampi, M.C., PLoS ONE, 2016, 10.1371/journal.pone.0147033
- Extracellular Vesicles from Ocular Melanoma Have Pro-Fibrotic and Pro-Angiogenic Properties on the Tumor Microenvironment, Solange Landreville, Alain Brisson, François Bordeleau, Julie Bérubé, Nathan Schoonjans, Enola Bollmann, Amel Ben Anes, Andrew Mitchell, Kelly Coutant, Léo Piquet, Cells, 2022, 10.3390/cells11233828
- Traction force microscopy for noninvasive imaging of cell forces, Adie, S.G., Reinhart-King, C.A., Bordeleau, F., Mulligan, J.A., Advances in Experimental Medicine and Biology, 2018, 10.1007/978-3-319-95294-9_15
- Regulation of ATP utilization during metastatic cell migration by collagen architecture, Reinhart-King, C.A., King, M.R., Lampi, M.C., VanderBurgh, J.A., Li, J., Bordeleau, F., Miller, J.P., Goldblatt, Z.E., Zanotelli, M.R., Molecular Biology of the Cell, 2018, 10.1091/mbc.E17-01-0041
- The Extracellular Matrix Stiffening: A Trigger of Prostate Cancer Progression and Castration Resistance?, François Bordeleau, David P. Labbé, Tarek Hallal, Carole Luthold, Cancers, 2022, 10.3390/cancers14122887
- Coupling Microfluidic Platforms, Microfabrication, and Tissue Engineered Scaffolds to Investigate Tumor Cells Mechanobiology, Francois Bordeleau, Carole Luthold, Raoua Ben Messaoud, Martial Millet, Micromachines, 2019, 10.3390/mi10060418
- Substrate stiffness regulates focal adhesion kinase alternative splicing in breast cancer, Bordeleau, F., Hussein, S., Khelifi, G., Bourriquen, G., Luthold, C., Pic, E., Millet, M., Biophysical journal, 2023, 10.1016/j.bpj.2022.11.1533
- Tissue transglutaminase 2 regulates tumor cell tensional homeostasis by increasing contractility, Cynthia A. Reinhart-King, Marc A. Antonyak, Richard A. Cerione, Alysha Simmons, Wenjun Wang, Francois Bordeleau, Journal of Cell Science, 2020, 10.1242/jcs.231134
- Clinical doses of radiation reduce collagen matrix stiffness, Reinhart-King, C.A., Pannullo, S.C., Bonassar, L.J., Parker, D.J., Lavalley, D.J., Zanotelli, M.R., Bordeleau, F., Borde, B.H., Miller, J.P., APL Bioengineering, 2018, 10.1063/1.5018327
- Substrate stiffness regulates PDGF-induced circular dorsal ruffle formation through MLCK, Reinhart-King, C.A., Kraning-Rush, C.M., Bordeleau, F., Huynh, J., Cellular and Molecular Bioengineering, 2013, 10.1007/s12195-013-0278-7
- Keratin contribution to cellular mechanical stress response at focal adhesions as assayed by laser tweezers, Marceau, N., Sheng, Y., Bessard, J., Bordeleau, F., Biochemistry and Cell Biology, 2008, 10.1139/O08-076
- ARHGEF17/TEM4 regulates the cell cycle through control of G1 progression, Sabine Elowe, François Bordeleau, Laurence Descombes, Alexsandro Dos Santos, Suparba Roy, Romain Devillers, Chantal Garand, Annie Lauzier, Eva Calvo, Diogjena Katerina Prifti, 2024, 10.1101/2024.04.14.589449
- Keratin 8/18 modulation of protein kinase C-mediated integrin-dependent adhesion and migration of liver epithelial cells, Marceau, N., Loranger, A., Gilbert, S., Galarneau, L., Bordeleau, F., Molecular Biology of the Cell, 2010, 10.1091/mbc.E09-05-0373
- Photonic force microscopy of local tension at cell surface focal adhesions, Sheng, Y., Marceau, N., Bessard, J., Bordeleau, F., Proceedings of SPIE - The International Society for Optical Engineering, 2006, 10.1117/12.706573
- Tension directs cancer cell migration over fiber alignment through energy minimization, Cynthia A. Reinhart-King, Francois Bordeleau, Elise Tahon, Ismael Ortiz, Wenjun Wang, Joseph P. Miller, Matthew R. Zanotelli, Biomaterials, 2024, 10.1016/j.biomaterials.2024.122682
- Phenotypic heterogeneity and metastasis of breast cancer cells, Reinhart-King, C.A., King, M.R., Li, J., Richardson, I.M., Marshall, J.R., Bordeleau, F., Lampi, M.C., Goldblatt, Z.E., McArdle, T.J., Ortiz-Otero, N., Mosier, J.A., Wang, W., Taufalele, P.V., Schwager, S.C., Carey, S.P., Hapach, L.A., Cancer Research, 2021, 10.1158/0008-5472.CAN-20-1799
- Cooperative effects of matrix stiffness and fluid shear stress on endothelial cell behavior, Reinhart-King, C.A., King, M.R., Mitchell, M.J., Mason, B.N., Zhou, A.L., Bordeleau, F., Zhou, D.W., Kohn, J.C., Biophysical Journal, 2015, 10.1016/j.bpj.2014.12.023
- Matrix stiffness regulates vascular integrity through focal adhesion kinase activity, Reinhart-King, C.A., Bordeleau, F., Lollis, E.M., Wang, W., FASEB Journal, 2019, 10.1096/fj.201800841R
- Matrix stiffness regulates tumor cell intravasation through expression and ESRP1-mediated alternative splicing of MENA, Reinhart-King, C.A., Bordeleau, F., Rowe, M.M., Schunk, C.T., Berestesky, E.D., Smart, K., Homsy, K., Millet, M., Taufalele, P.V., Wang, W., Cell Reports, 2023, 10.1016/j.celrep.2023.112338
- Beneficial Effects of Exercise on Subendothelial Matrix Stiffness are Short-Lived, Reinhart-King, C.A., Putnam, D., Azar, J., Ma, J., Modi, S., Watkins, H.C., Miller, J., Bordeleau, F., Kohn, J.C., Journal of Biomechanical Engineering, 2018, 10.1115/1.4039579
- Measurement of dynamic cell-induced 3D displacement fields in vitro for traction force optical coherence microscopy, Adie, S.G., Reinhartking, C.A., Bordeleau, F., Mulligan, J.A., Biomedical Optics Express, 2017, 10.1364/BOE.8.001152
- Keratin 8/18 regulation of cell stiffness-extracellular matrix interplay through modulation of rho-mediated actin cytoskeleton dynamics, Marceau, N., Sheng, Y., Lapierre, M.-E., Bordeleau, F., PLoS ONE, 2012, 10.1371/journal.pone.0038780
- Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making, Cynthia A. Reinhart-King, Francois Bordeleau, David Erickson, Aadhar Jain, Paul V. Taufalele, Jacob A. VanderBurgh, Aniqua Rahman-Zaman, Matthew R. Zanotelli, Nature Communications, 2019, 10.1038/s41467-019-12155-z
- Author Correction: Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making, Cynthia A. Reinhart-King, Francois Bordeleau, David Erickson, Aadhar Jain, Paul V. Taufalele, Jacob A. VanderBurgh, Aniqua Rahman-Zaman, Matthew R. Zanotelli, Nature Communications, 2019, 10.1038/s41467-019-13655-8
- Tissue stiffness regulates serine/arginine-rich protein-mediated splicing of the extra domain B-fibronectin isoform in tumors, Anseth, K.S., Reinhart-King, C.A., Weiss, R.S., Shin, S.J., LaValley, D.J., Mason, B.N., Abril, Y.L.N., Califano, J.P., Bordeleau, F., Proceedings of the National Academy of Sciences of the United States of America, 2015, 10.1073/pnas.1505421112
- Improving fascin inhibitors to block tumor cell migration and metastasis, Huang, X.-Y., Zhang, J.J., Li, W., Reinhart-King, C.A., Bordeleau, F., Xing, B., Liu, B., Huang, J., Han, S., Molecular Oncology, 2016, 10.1016/j.molonc.2016.03.006
- Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation, Antonyak, M.A., Cerione, R.A., Reinhart-King, C.A., Bordeleau, F., Desrochers, L.M., Nature Communications, 2016, 10.1038/ncomms11958
...
Contribution à l'enseignement aux cycles supérieurs
Étudiant(e)s dirigé(e)s*
Depuis 2020/06- Juliette Gouhier - Doctorat - En cours
- Laurence Carignan - Doctorat - En cours
- Olivier Chancy - Doctorat - En cours
- Carole Luthold - Post-doctorat - En cours
- Mathilde Lavigne - Doctorat - En cours
- Elise Jeanne Marie Tahon - Doctorat - En cours
- Seyed Mohammad Reza Rafieipour Alavi - Post-doctorat - En cours
- Félix-Antoine Pellerin - Maîtrise avec mémoire - En cours
- Martial Millet - Doctorat - En cours
- Enola Bollmann - Maîtrise avec mémoire - 2023/01
- Kevin Homsy - Maîtrise avec mémoire - 2024/05
- Nafiseh Sadat Mousavi Maleki - Maîtrise avec mémoire - 2024/09
Encadrement d'étudiant(e)s
Direction de recherche dans les domaines suivants :
- Biologie cellulaire et moléculaire
En savoir plus sur les programmes
Disponibilité d'encadrement d'étudiant(e)s
Ce (cette) professeur(e) est présentement à la recherche d'étudiant(e)s.
Envoyer un courriel*Les supervisions d’étudiant(e)s de 1er cycle en
stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées
ultérieurement.