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François Bordeleau

Professeur agrégé

François Bordeleau
francois.bordeleau@fmed.ulaval.ca
Centre de recherche sur le cancer
Centre de recherche du CHU de Québec - Université Laval
Centre de recherche en organogenèse expérimentale
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Oncologie
Bioinformatique / données massives (big data)
Médecine régénératrice et médecine moléculaire

Domaines et intérêts de recherche du (de la) professeur(e) :

Cancer
  • Cancer la prostate
  • Cancer du sein
  • Carcinogénèse
  • Diagnostic et détection du cancer
  • Signalisation cellulaire et cancer
  • Facteurs de croissance
  • Génétique du cancer
Cellulaire
  • Cellule
Subcellulaire
Génomique et protéomique
  • Bio-informatique
  • Biotechnologie
  • Mécanismes biologiques et biochimiques
  • Technologies biomédicales
Organisation et fonctions biologiques
Organismes vivants (êtres humains - Psychologie/aspects biologiques)
Outils mathématiques et informatiques
  • Analyse mathématique
  • Analyse numérique
  • Modélisation et simulation
  • Approche théorique
Outils de caractérisation
  • Imagerie
  • Propriétés rhéologiques

Projets de recherche

  • Protein glycation acts as a substrate-dependent tumorigenic molecular switch in prostate cancer - Instituts de recherche en santé du Canada - Subvention Projet, Institut de recherche du Centre universitaire de santé McGill, co-chercheur - 2022-04-01 au 2027-03-31
  • Creating a biomimetic 3D engineered model of the liver metastatic niche - Secrétariat des programmes interorganismes à l’intention des établissements - Nouvelles frontières en recherche, chercheur principal - 2024-03-31 au 2026-03-30
  • Canada Research Chair in Tumor Mechanoregulation - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2020-07-01 au 2025-06-30
  • Mise en place de la plateforme d'ingénierie tissulaire en cancer - Fondation Canadienne pour l'innovation (La), Ministère de la Santé et des Services sociaux, Advanced Solutions - Fonds d'innovation (FI), chercheur principal - 2023-07-01 au 2025-03-31
  • Programme de soutien aux nouveaux détenteurs de CRC - Université Laval - Fonds internes - Fonds de soutien aux professeurs-chercheurs bénéficiant d’une Chaire de recherche du Canada, chercheur principal - 2022-05-01 au 2024-04-30
  • Hepatic stellate cells as a driver of the pre-metastatic niche in uveal melanoma - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2023-03-01 au 2024-02-29
  • Thérapie photodynamique véctorisée du cancer de la vessie: étude sur un modèle 3D reconstruit par génie tissulaire - Fonds de recherche du Québec - Nature et technologies - Programme Samuel-De Champlain, chercheur principal - 2021-04-01 au 2023-03-31
  • The combined role of cellular force dynamics and extracellular matrix mechanical properties in driving angiogenesis - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2018-04-01 au 2023-03-31
  • Exploration of a novel therapeutic strategy impeding triple-negative breast cancer growth and progression - Fondation de l'Université Laval, co-chercheur - 2022-04-01 au 2023-03-31
  • Toward elucidating the interplay between cell contractility state, mechanotransduction and alternative splicing during tumor progression - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2022-03-01 au 2023-02-28
  • Mécanobiologie du cancer: rôle intégrateur de la contractilité cellulaire sur le potentiel métastatique cellulaire - Fonds de recherche du Québec - Santé - Établissement de jeunes chercheurs - Juniors 1, chercheur principal - 2018-07-01 au 2022-06-30

Publications

  • Intermediate Filaments, Bordeleau, F., Gilbert, S., Loranger, A., Marceau, N., Cellular Domains, 2011, 10.1002/9781118015759.ch16
  • Phenotypic heterogeneity and metastasis of breast cancer cells, Reinhart-King, C.A., King, M.R., Li, J., Richardson, I.M., Marshall, J.R., Bordeleau, F., Lampi, M.C., Goldblatt, Z.E., McArdle, T.J., Ortiz-Otero, N., Mosier, J.A., Wang, W., Taufalele, P.V., Schwager, S.C., Carey, S.P., Hapach, L.A., Cancer Research, 2021, 10.1158/0008-5472.CAN-20-1799
  • Quantitative assessment of cell contractility using polarized light microscopy, Francois Bordeleau, Cynthia A. Reinhart‐King, Susan C. Pannullo, Joseph P. Miller, Wenjun Wang, Journal of Biophotonics, 2018, 10.1002/jbio.201800008
  • Vinculin regulates directionality and cell polarity in two-And three-dimensional matrix and three-dimensional microtrack migration, Reinhart-King, C.A., García, A.J., Lin, D.Y., Lampi, M.C., Bordeleau, F., Goldblatt, Z.E., Kraning-Rush, C.M., Carey, S.P., Rahman, A., Molecular Biology of the Cell, 2016, 10.1091/mbc.E15-06-0432
  • Using Machine Learning to Predict TP53 Mutation Status and Aggressiveness of Prostate Cancer from Routine Histology Images, François Bordeleau, Cancer Research, 2023, 10.1158/0008-5472.CAN-23-1856
  • Microvesicles released from tumor cells disrupt epithelial cell morphology and contractility, Reinhart-King, C.A., Cerione, R.A., Lampi, M.C., Antonyak, M.A., Chan, B., Bordeleau, F., Journal of Biomechanics, 2016, 10.1016/j.jbiomech.2015.10.003
  • Subcellular regulation of cancer cell mechanics, Reinhart-King, C.A., Bordeleau, F., Zanotelli, M.R., Current Opinion in Biomedical Engineering, 2017, 10.1016/j.cobme.2017.02.001
  • Keratin 8/18 modulation of protein kinase C-mediated integrin-dependent adhesion and migration of liver epithelial cells, Marceau, N., Loranger, A., Gilbert, S., Galarneau, L., Bordeleau, F., Molecular Biology of the Cell, 2010, 10.1091/mbc.E09-05-0373
  • Synergic Interactions Between Hepatic Stellate Cells and Uveal Melanoma in Metastatic Growth, Solange Landreville, François Bordeleau, Peter R. A. Gerges, Julie Bérubé, Martial Millet, Nathan Schoonjans, Louise Dewit, Léo Piquet, Cancers, 2019, 10.3390/cancers11081043
  • Energetic regulation of coordinated leader–follower dynamics during collective invasion of breast cancer cells, Reinhart-King, C.A., Bordeleau, F., Taufalele, P.V., Wang, W., Goliwas, K.F., Zhang, J., Proceedings of the National Academy of Sciences of the United States of America, 2019, 10.1073/pnas.1809964116
  • Extent of Cell Confinement in Microtracks Affects Speed and Results in Differential Matrix Strains, Cynthia A. Reinhart-King, Brenton D. Hoffman, Francois Bordeleau, Jacob A. VanderBurgh, Matthew R. Zanotelli, Aniqua Rahman-Zaman, Jenna A. Mosier, Biophysical Journal, 2019, 10.1016/j.bpj.2019.09.024
  • Traction force microscopy for noninvasive imaging of cell forces, Adie, S.G., Reinhart-King, C.A., Bordeleau, F., Mulligan, J.A., Advances in Experimental Medicine and Biology, 2018, 10.1007/978-3-319-95294-9_15
  • Topographical guidance of 3D tumor cell migration at an interface of collagen densities, Reinhart-King, C.A., Tang, L.N., Bordeleau, F., Physical Biology, 2013, 10.1088/1478-3975/10/6/065004
  • Matrix stiffness regulates vascular integrity through focal adhesion kinase activity, Reinhart-King, C.A., Bordeleau, F., Lollis, E.M., Wang, W., FASEB Journal, 2019, 10.1096/fj.201800841R
  • Adenoviral protein E4orf4 interacts with the polarity protein par3 to induce nuclear rupture and tumor cell death, Lavoie, J.N., Huot, M.-É., Bordeleau, F., Richard, D.E., Laprise, P., Lambert, H., Fuchs, M., Bergeman, J., Boulanger, M.-C., Jacquet, K., Caillier, A., Rodrigue, M.-A., Dziengelewski, C., Journal of Cell Biology, 2020, 10.1083/JCB.201805122
  • Photonic force microscopy of local tension at cell surface focal adhesions, Sheng, Y., Marceau, N., Bessard, J., Bordeleau, F., Proceedings of SPIE - The International Society for Optical Engineering, 2006, 10.1117/12.706573
  • Weakly migratory metastatic breast cancer cells activate fibroblasts via microvesicle-Tg2 to facilitate dissemination and metastasis, Reinhart-King, C.A., Cerione, R.A., Antonyak, M.A., Bordeleau, F., Bates, M.E., Jayathilake, A.L., Schunk, C., Wang, W., McArdle, T.J., Mosier, J.A., Carlson, C.M., Hapach, L.A., Young, K.M., Schwager, S.C., eLife, 2022, 10.7554/ELIFE.74433
  • Probing the Biophysical Properties of Primary Breast Tumor-Derived Fibroblasts, Reinhart-King, C.A., Shin, S.J., Varma, S., Somasegar, S., Kowal, D.R., Lampi, M.C., Carey, S.P., Bordeleau, F., Alcoser, T.A., Cellular and Molecular Bioengineering, 2015, 10.1007/s12195-014-0360-9
  • Measurement of dynamic cell-induced 3D displacement fields in vitro for traction force optical coherence microscopy, Adie, S.G., Reinhartking, C.A., Bordeleau, F., Mulligan, J.A., Biomedical Optics Express, 2017, 10.1364/BOE.8.001152
  • Weakly migratory metastatic breast cancer cells activate fibroblasts via microvesicle-Tg2 to facilitate dissemination and metastasis, Cynthia A. Reinhart-King, Richard A. Cerione, Marc A. Antonyak, Francois Bordeleau, Anissa L. Jayathilake, Wenjun Wang, Tanner J. McArdle, Jenna A. Mosier, Caroline M. Carlson, Lauren A. Hapach, Samantha C. Schwager, 2021, 10.1101/2021.10.27.466095
  • Chaperone-Assisted Mitotic Actin Remodeling by BAG3 and HSPB8 Involves the Deacetylase HDAC6 and Its Substrate Cortactin, Josée N. Lavoie, François Bordeleau, Herman Lambert, Alice-Anaïs Varlet, Carole Luthold, International Journal of Molecular Sciences, 2020, 10.3390/ijms22010142
  • Improving fascin inhibitors to block tumor cell migration and metastasis, Huang, X.-Y., Zhang, J.J., Li, W., Reinhart-King, C.A., Bordeleau, F., Xing, B., Liu, B., Huang, J., Han, S., Molecular Oncology, 2016, 10.1016/j.molonc.2016.03.006
  • Substrate stiffness regulates PDGF-induced circular dorsal ruffle formation through MLCK, Reinhart-King, C.A., Kraning-Rush, C.M., Bordeleau, F., Huynh, J., Cellular and Molecular Bioengineering, 2013, 10.1007/s12195-013-0278-7
  • Extracellular Vesicles from Ocular Melanoma Have Pro-Fibrotic and Pro-Angiogenic Properties on the Tumor Microenvironment, Solange Landreville, Alain Brisson, François Bordeleau, Julie Bérubé, Nathan Schoonjans, Enola Bollmann, Amel Ben Anes, Andrew Mitchell, Kelly Coutant, Léo Piquet, Cells, 2022, 10.3390/cells11233828
  • Matrix stiffening promotes a tumor vasculature phenotype, Reinhart-King, C.A., Weiss, R.S., Butcher, J.T., Bonassar, L.J., Hassane, D.C., Abril, Y.L.N., Mencia-Trinchant, N., Huynh, J., LaValley, D.J., Montague, C., Califano, J.P., Somasegar, S., Zanotelli, M.R., Mazzola, M., Lollis, E.M., Mason, B.N., Bordeleau, F., Proceedings of the National Academy of Sciences of the United States of America, 2017, 10.1073/pnas.1613855114
  • Matrix stiffness regulates microvesicle-induced fibroblast activation, Reinhart-King, C.A., Cerione, R.A., Antonyak, M.A., Zhang, J., Bordeleau, F., Schwager, S.C., American Journal of Physiology - Cell Physiology, 2019, 10.1152/ajpcell.00418.2018
  • Tissue transglutaminase regulates tumor cell tensional homeostasis by increasing contractility, Cynthia A. Reinhart-King, Richard A. Cerione, Marc A. Antonyak, Alysha Simmons, Wenjun Wang, Francois Bordeleau, Journal of Cell Science, 2019, 10.1242/jcs.231134
  • Cooperative effects of matrix stiffness and fluid shear stress on endothelial cell behavior, Reinhart-King, C.A., King, M.R., Mitchell, M.J., Mason, B.N., Zhou, A.L., Bordeleau, F., Zhou, D.W., Kohn, J.C., Biophysical Journal, 2015, 10.1016/j.bpj.2014.12.023
  • ARHGEF17/TEM4 regulates the cell cycle through control of G1 progression, Sabine Elowe, François Bordeleau, Laurence Descombes, Alexsandro Dos Santos, Suparba Roy, Romain Devillers, Chantal Garand, Annie Lauzier, Eva Calvo, Diogjena Katerina Prifti, 2024, 10.1101/2024.04.14.589449
  • Author Correction: Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making, Cynthia A. Reinhart-King, Francois Bordeleau, David Erickson, Aadhar Jain, Paul V. Taufalele, Jacob A. VanderBurgh, Aniqua Rahman-Zaman, Matthew R. Zanotelli, Nature Communications, 2019, 10.1038/s41467-019-13655-8
  • Vascular smooth muscle cell matrix-degradation by podosomes, Reinhart-King, C.A., Bordeleau, F., Kohn, J.C., Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC, 2013, 10.1109/NEBEC.2013.151
  • Keratin 8/18 regulation of cell stiffness-extracellular matrix interplay through modulation of rho-mediated actin cytoskeleton dynamics, Marceau, N., Sheng, Y., Lapierre, M.-E., Bordeleau, F., PLoS ONE, 2012, 10.1371/journal.pone.0038780
  • Tissue stiffness regulates serine/arginine-rich protein-mediated splicing of the extra domain B-fibronectin isoform in tumors, Anseth, K.S., Reinhart-King, C.A., Weiss, R.S., Shin, S.J., LaValley, D.J., Mason, B.N., Abril, Y.L.N., Califano, J.P., Bordeleau, F., Proceedings of the National Academy of Sciences of the United States of America, 2015, 10.1073/pnas.1505421112
  • Clinical doses of radiation reduce collagen matrix stiffness, Reinhart-King, C.A., Pannullo, S.C., Bonassar, L.J., Parker, D.J., Lavalley, D.J., Zanotelli, M.R., Bordeleau, F., Borde, B.H., Miller, J.P., APL Bioengineering, 2018, 10.1063/1.5018327
  • Substrate stiffness regulates focal adhesion kinase alternative splicing in breast cancer, Bordeleau, F., Hussein, S., Khelifi, G., Bourriquen, G., Luthold, C., Pic, E., Millet, M., Biophysical journal, 2023, 10.1016/j.bpj.2022.11.1533
  • Matrix stiffness enhances cancer-macrophage interactions and M2-like macrophage accumulation in the breast tumor microenvironment, Reinhart-King, C.A., Bordeleau, F., Hassane, D.C., Lau, K.S., King, M.R., Greenlee, J.D., Chen, B., Southard-Smith, A.N., Simmons, A.J., Wang, W., Taufalele, P.V., Acta Biomaterialia, 2023, 10.1016/j.actbio.2022.04.031
  • Tuning cell migration: Contractility as an integrator of intracellular signals from multiple cues [version 1; referees: 2 approved], Reinhart-King, C.A., Bordeleau, F., F1000Research, 2016, 10.12688/F1000RESEARCH.7884.1
  • Matrix stiffness regulates tumor cell intravasation through expression and ESRP1-mediated alternative splicing of MENA, Reinhart-King, C.A., Bordeleau, F., Rowe, M.M., Schunk, C.T., Berestesky, E.D., Smart, K., Homsy, K., Millet, M., Taufalele, P.V., Wang, W., Cell Reports, 2023, 10.1016/j.celrep.2023.112338
  • Antigen detection at atomolar concentration using an optical tweezers, Sheng, Y., Marceau, N., Bordeleau, F., Laliberté, M., Proceedings of SPIE - The International Society for Optical Engineering, 2009, 10.1117/12.839769
  • Beneficial Effects of Exercise on Subendothelial Matrix Stiffness are Short-Lived, Reinhart-King, C.A., Putnam, D., Azar, J., Ma, J., Modi, S., Watkins, H.C., Miller, J., Bordeleau, F., Kohn, J.C., Journal of Biomechanical Engineering, 2018, 10.1115/1.4039579
  • Simvastatin ameliorates matrix stiffness-mediated endothelial monolayer disruption, Reinhart-King, C.A., Zanotelli, M.R., Bordeleau, F., Huynh, J., Faber, C.J., Lampi, M.C., PLoS ONE, 2016, 10.1371/journal.pone.0147033
  • Coordination of non-professional efferocytosis and actomyosin contractility during epithelial tissue morphogenesis, Bouchard, M., Khadra, A., Bordeleau, F., Côté, J.-F., Tran, V., Schindler, M., Homsy, K., Luthold, C., Graham-Paquin, A.-L., Ponsin, K., Tang, Y.C., Cell Reports, 2023, 10.1016/j.celrep.2023.112202
  • Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation, Antonyak, M.A., Cerione, R.A., Reinhart-King, C.A., Bordeleau, F., Desrochers, L.M., Nature Communications, 2016, 10.1038/ncomms11958
  • Measuring integrated cellular mechanical stress response at focal adhesions by optical tweezers, Shenga, Y., Marceau, N., Bessard, J., Bordeleau, F., Journal of Biomedical Optics, 2011, 10.1117/1.3626864
  • The Extracellular Matrix Stiffening: A Trigger of Prostate Cancer Progression and Castration Resistance?, François Bordeleau, David P. Labbé, Tarek Hallal, Carole Luthold, Cancers, 2022, 10.3390/cancers14122887
  • Targeted inhibition of fascin function blocks tumour invasion and metastatic colonization, Huang, X.-Y., Zhang, J.J., Reinhart-King, C.A., Bordeleau, F., Liu, B., Huang, J., Xing, B., Han, S., Huang, F.-K., Nature Communications, 2015, 10.1038/ncomms8465
  • Regulation of ATP utilization during metastatic cell migration by collagen architecture, Reinhart-King, C.A., King, M.R., Lampi, M.C., VanderBurgh, J.A., Li, J., Bordeleau, F., Miller, J.P., Goldblatt, Z.E., Zanotelli, M.R., Molecular Biology of the Cell, 2018, 10.1091/mbc.E17-01-0041
  • High type I collagen density fails to increase breast cancer stem cell phenotype, Vanessa M. Freitas, Cynthia A. Reinhart-King, Murilo V. Geraldo, Karen S.C. Borbely, Luciana M. Dzik, François Bordeleau, Ana Carolina L. Ralph, Iuri C. Valadão, PeerJ, 2020, 10.7717/peerj.9153
  • Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making, Cynthia A. Reinhart-King, Francois Bordeleau, David Erickson, Aadhar Jain, Paul V. Taufalele, Jacob A. VanderBurgh, Aniqua Rahman-Zaman, Matthew R. Zanotelli, Nature Communications, 2019, 10.1038/s41467-019-12155-z
  • Keratin contribution to cellular mechanical stress response at focal adhesions as assayed by laser tweezers, Marceau, N., Sheng, Y., Bessard, J., Bordeleau, F., Biochemistry and Cell Biology, 2008, 10.1139/O08-076
  • Coupling Microfluidic Platforms, Microfabrication, and Tissue Engineered Scaffolds to Investigate Tumor Cells Mechanobiology, Francois Bordeleau, Carole Luthold, Raoua Ben Messaoud, Martial Millet, Micromachines, 2019, 10.3390/mi10060418
  • Cancer-Associated Fibroblasts in a 3D Engineered Tissue Model Induce Tumor-like Matrix Stiffening and EMT Transition, François Bordeleau, Stéphane Bolduc, Frédéric Pouliot, Marc-Étienne Huot, Stéphane Chabaud, Geneviève Bernard, Cassandra Ringuette Goulet, Enola Bollmann, Martial Millet, Cancers, 2022, 10.3390/cancers14153810
  • Physical biology in cancer. 5. The rocky road of metastasis: The role of cytoskeletal mechanics in cell migratory response to 3D matrix topography, Reinhart-King, C.A., Alcoser, T.A., Bordeleau, F., American Journal of Physiology - Cell Physiology, 2014, 10.1152/ajpcell.00283.2013

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Laurence Carignan - Maîtrise avec mémoire - En cours
  • Elise Jeanne Marie Tahon - Doctorat - En cours
  • Martial Millet - Doctorat - En cours
  • Olivier Chancy - Doctorat - En cours
  • Mathilde Lavigne - Doctorat - En cours
  • Juliette Gouhier - Doctorat - En cours
  • Kevin Homsy - Maîtrise avec mémoire - En cours
  • Seyed Mohammad Reza Rafieipour Alavi - Post-doctorat - En cours
  • Félix-Antoine Pellerin - Maîtrise avec mémoire - En cours
  • Nafiseh Sadat Mousavi Maleki - Maîtrise avec mémoire - En cours
  • Enola Bollmann - Maîtrise avec mémoire - 2023/01

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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