Découvrez nos professeurs et professeures!
Étienne Audet-Walsh
Professeur agrégé
Contribution à la recherche
Axe de recherche de l'Université Laval :
Santé et bien-être durables
Thématiques de recherche de la Faculté de médecine :
Oncologie
Domaines et intérêts de recherche du (de la) professeur(e) :
Cancer
- Apoptose et cancer
- Cancer la prostate
- Cancer de l'appareil reproducteur
- Cancer du sein
- Cancers hormonaux-dépendants
- Carcinogénèse
Nutrition et métabolisme
Cellulaire
Génomique et protéomique
Projets de recherche
- Unravelling the role of primary cilia in prostate cancer initiation and progression - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2023-04-01 au 2028-03-31
- Understanding mitochondrial metabolism to identify prostate cancer metabolic vulnerabilities - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2022-10-01 au 2027-09-30
- Impact of 2-hydroxyglutarate-induced astrocytes reactivity in low-grade glioma progression and recurrence - Société de recherche sur le cancer - Subvention de fonctionnement, co-chercheur - 2024-09-01 au 2026-08-31
- Targeting the sonic hedgehog medulloblastoma metabolic program for therapeutic purposes - Société de recherche sur le cancer - Subvention de fonctionnement, chercheur principal - 2024-09-01 au 2026-08-31
- Mitochondria bound to lipid droplets as new regulators of insulin resistance - Diabète Canada - Subvention de fonctionnement : Mettre fin au diabète prix 2022, co-chercheur - 2022-12-01 au 2025-11-30
- Microfluidic-based detection of citrate levels in human semen - Conseil de recherches en sciences naturelles et génie Canada - Subventions Alliance - Internationale - Catalyseur, chercheur principal - 2024-09-02 au 2025-09-01
- Targeting the prostate cancer metabolic program established upon loss of the KLF5 gene - Société de recherche sur le cancer - Subvention de fonctionnement, chercheur principal - 2023-09-01 au 2025-08-31
- Amino acid neurotransmitter reprogramming of the tumour microenvironment and metabolism in glioblastoma - Société de recherche sur le cancer - Subvention de fonctionnement, co-chercheur - 2023-09-01 au 2025-08-31
- Canada Research Chair in Targeting metabolic vulnerabilities for the treatment of hormone-sensitive cancers - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2020-07-01 au 2025-06-30
- Hydrochlorothiazide and accelerated CKD-related vascular calcification - Fondation canadienne du rein - Subventions de recherche en santé des reins, co-chercheur - 2023-07-01 au 2025-06-30
- Approche novatrice pour l'étude du lait maternel en contexte de diabète gestationnel : Utilisation d'un modèle d’organoïdes de la glande mammaire - Fondation de la recherche pédiatrique, Fonds de recherche du Québec - Santé - Initiative structurante intercentre, co-chercheur - 2024-01-31 au 2025-03-31
- Impact des perturbations endocriniennes sur le métabolisme de la prostate - Université Laval - Fonds internes - BDR - Contributions, chercheur principal - 2023-12-07 au 2024-12-31
- Utilisation de modèles d'organoïdes de la glande mammaire pour l'étude du lait maternel en contexte de diabète gestationnel - Université Laval - Fonds internes - BDR - Contributions, co-chercheur - 2023-12-07 au 2024-12-31
- Regulation of Cellular Energy Metabolism in Mammary Epithelial Cells - Conseil de recherches en sciences naturelles et génie Canada, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2019-04-01 au 2024-03-31
- Génomique fonctionnelle des récepteurs aux hormones stéroïdiennes dans le contrôle du métabolisme énergétique des cellules de cancer de la prostate - Fonds de recherche du Québec - Santé - Établissement de jeunes chercheurs - Juniors 1, chercheur principal - 2019-07-01 au 2023-06-30
- ABCB10 reprograms mitochondria in pro-inflammatory macrophages of obese mice - CHU de Québec – Université Laval – CHUL - Subvention de fonctionnement de centre, co-chercheur - 2022-09-21 au 2023-03-31
- Caractérisation du protéome mitochondrial de la prostate - CHU de Québec – Université Laval – CHUL - Subvention de fonctionnement de centre, chercheur principal - 2022-09-21 au 2023-03-31
- Functional interaction between the androgen and the estrogen signalling pathways in prostate cancer - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2018-10-01 au 2023-03-31
- What are my options? A feasibility study of a personalized primary prevention strategy for women and men at high risk of breast and prostate cancer - Instituts de recherche en santé du Canada, Fondation du cancer du sein du Québec, Société canadienne du cancer - Initiative SCC/IC-IRSC en prévention primaire du cancer, co-chercheur - 2022-01-15 au 2023-01-14
- Utilisation du dosage du citrate pour le dépistage du cancer de la prostate - Fondation du CHU de Québec, chercheur principal - 2021-11-15 au 2022-11-14
Publications
- SRD5A polymorphisms and biochemical failure after radical prostatectomy., Lévesque E, Guillemette C, Girard H, Douville P, Bao BY, Huang SP, Fradet V, Fradet Y, Lacombe L, Nadeau G, Bellemare J, Audet-Walsh E, European urology, 2011, 10.1016/j.eururo.2011.06.020
- The PGC-1α/ERRα Axis Represses One-Carbon Metabolism and Promotes Sensitivity to Anti-folate Therapy in Breast Cancer., St-Pierre J, Giguère V, Bourque G, Caron M, Bridon G, Yee T, Gravel SP, Papadopoli DJ, Audet-Walsh É, Cell reports, 2016, 10.1016/j.celrep.2015.12.086
- Werner's syndrome helicase participates in transcription of phenobarbital-inducible CYP2B genes in rat and mouse liver., Anderson A, Lebel M, Audet-Walsh E, Massip L, Auclair-Vincent S, Lachaud AA, Biochemical pharmacology, 2009, 10.1016/j.bcp.2009.09.002
- Alternative promoters control UGT2B17-dependent androgen catabolism in prostate cancer and its influence on progression., Guillemette C, Droit A, Leclercq M, Villeneuve L, Caron P, Turcotte V, Brisson H, Rouleau M, Melo-Garcia L, Allain ÉP, Hovington H, Labriet A, Lévesque E, British journal of cancer, 2020, 10.1038/s41416-020-0749-2
- Circulating estrogens in endometrial cancer cases and their relationship with tissular expression of key estrogen biosynthesis and metabolic pathways., Guillemette C, Bélanger A, Villeneuve L, Caron P, Brisson J, Ayotte P, Ménard V, Plante M, Têtu B, Grégoire J, Audet-Walsh E, Lépine J, The Journal of clinical endocrinology and metabolism, 2010, 10.1210/jc.2010-2648
- Impacts of endocrine-disrupting chemicals on prostate function and cancer., Audet-Walsh É, Pelletier M, Peillex C, Lafront C, Lacouture A, Environmental research, 2021, 10.1016/j.envres.2021.112085
- Profiling endogenous serum estrogen and estrogen-glucuronides by liquid chromatography-tandem mass spectrometry., Guillemette C, Bélanger A, Lépine J, Audet-Walsh E, Caron P, Analytical chemistry, 2009, 10.1021/ac9019126
- An Aminosteroid Derivative Shows Higher In Vitro and In Vivo Potencies than Gold Standard Drugs in Androgen-Dependent Prostate Cancer Models, Etienne Audet-Walsh, Cindy Weidmann, rene maltais, Jenny Roy, Donald Poirier, Cancers, 2023, 10.3390/cancers15113033
- Integrated multi-omics analysis of adverse cardiac remodeling and metabolic inflexibility upon ErbB2 and ERRα deficiency., Giguère V, Smith HW, Guluzian C, Sanguin-Gendreau V, Zuo D, Ouellet C, Scholtes C, Dejgaard K, Gainullina A, Kuzmanov U, Perry MC, B'chir W, Xia H, Dufour CR, Communications biology, 2022, 10.1038/s42003-022-03942-4
- Inverse Regulation of DHT Synthesis Enzymes 5α-Reductase Types 1 and 2 by the Androgen Receptor in Prostate Cancer., Giguère V, Tam IS, Yee T, Audet-Walsh É, Endocrinology, 2017, 10.1210/en.2016-1926
- Low expression of PGC-1β and other mitochondrial biogenesis modulators in melanoma is associated with growth arrest and the induction of an immunosuppressive gene expression program dependent on MEK and IRF-1., Gravel SP, Audet-Walsh É, Méribout N, Salazar A, Coutu-Beaudry K, Laurin KM, Cancer letters, 2022, 10.1016/j.canlet.2022.215738
- Dexamethasone induction of murine CYP2B genes requires the glucocorticoid receptor., Anderson A, Audet-Walsh E, Drug metabolism and disposition: the biological fate of chemicals, 2008, 10.1124/dmd.108.022772
- A FACS-Free Purification Method to Study Estrogen Signaling, Organoid Formation, and Metabolic Reprogramming in Mammary Epithelial Cells., Audet-Walsh É, Pelletier M, Laverdière I, Bastien D, Berthiaume L, Weidmann C, Jobin C, Lacouture A, Frontiers in endocrinology, 2021, 10.3389/fendo.2021.672466
- The multiple universes of estrogen-related receptor α and γ in metabolic control and related diseases., Giguére V, Audet-Walsh É, Acta pharmacologica Sinica, 2014, 10.1038/aps.2014.121
- Functional genomic studies reveal the androgen receptor as a master regulator of cellular energy metabolism in prostate cancer., Audet-Walsh É, Poluri RTK, Gonthier K, The Journal of steroid biochemistry and molecular biology, 2019, 10.1016/j.jsbmb.2019.04.016
- The impact of germline genetic variations in hydroxysteroid (17-beta) dehydrogenases on prostate cancer outcomes after prostatectomy., Lévesque É, Guillemette C, Fradet V, Douville P, Fradet Y, Lacombe L, Bellemare J, Audet-Walsh É, European urology, 2011, 10.1016/j.eururo.2011.12.021
- The UGT1 locus is a determinant of prostate cancer recurrence after prostatectomy., Guillemette C, Lévesque É, Lacombe L, Fradet Y, Caron P, Audet-Walsh É, Flageole C, Laverdière I, Endocrine-related cancer, 2014, 10.1530/erc-14-0423
- A Systematic Study of the Impact of Estrogens and Selective Estrogen Receptor Modulators on Prostate Cancer Cell Proliferation., Audet-Walsh É, Weidmann C, Germain L, Lafront C, Scientific reports, 2020, 10.1038/s41598-020-60844-3
- KLF5 and NFYA factors as novel regulators of prostate cancer cell metabolism., Audet-Walsh É, Pelletier M, Guillemette C, Droit A, Weidmann C, Joly-Beauparlant C, Lafront C, Allain ÉP, Paquette V, Poluri RTK, Endocrine-related cancer, 2021, 10.1530/erc-20-0504
- A Nutrient-Based Cellular Model to Characterize Acetylation-Dependent Protein-Protein Interactions., Lambert JP, Audet-Walsh É, Linteau N, Noufi C, Gonthier K, Kougnassoukou Tchara PE, Loehr J, Frontiers in molecular biosciences, 2022, 10.3389/fmolb.2022.831758
- Loss of hepatic Flcn protects against fibrosis and inflammation by activating autophagy pathways., Pause A, Audet-Walsh É, Siegel PM, Estall JL, Giguère V, Pacis A, Jeong H, Dufour CR, Biondini M, El-Houjeiri L, Yan M, Ramírez-Reyes JMJ, Paquette M, Scientific reports, 2021, 10.1038/s41598-021-99958-7
- Correlation between prostate volume and single nucleotide polymorphisms implicated in the steroid pathway., Cancel-Tassin G, Lévesque E, Cussenot O, Guillemette C, Chanock S, Cormier L, Roupret M, Azzouzi AR, Fournier G, Valeri A, Bigot P, Drouin S, Audet-Walsh E, Cornu JN, World journal of urology, 2016, 10.1007/s00345-016-1869-4
- Editorial: AMPK and mTOR Beyond Signaling: Emerging Roles in Transcriptional Regulation., Viollet B, Vernier M, Audet-Walsh É, Frontiers in cell and developmental biology, 2020, 10.3389/fcell.2020.641552
- Multiple metabolic pathways fuel the truncated tricarboxylic acid cycle of the prostate to sustain constant citrate production and secretion., Audet-Walsh É, Fradet Y, Bergeron A, Bastien D, Jobin C, Neveu B, Pelletier JF, Gonthier K, Harvey M, Weidmann C, Berthiaume L, Lacouture A, Frégeau-Proulx L, Molecular metabolism, 2022, 10.1016/j.molmet.2022.101516
- Steroidogenic germline polymorphism predictors of prostate cancer progression in the estradiol pathway., Guillemette C, Lacombe L, Fradet Y, Rouleau M, Caron P, Audet-Walsh E, Laverdière I, Lévesque E, Clinical cancer research : an official journal of the American Association for Cancer Research, 2014, 10.1158/1078-0432.ccr-13-2567
- Deletions of the androgen-metabolizing UGT2B genes have an effect on circulating steroid levels and biochemical recurrence after radical prostatectomy in localized prostate cancer., Lévesque E, Guillemette C, Lacombe L, Fradet Y, Caron P, Douville P, Bao BY, Huang SP, Flageole C, Audet-Walsh É, Bellemare J, Nadeau G, The Journal of clinical endocrinology and metabolism, 2011, 10.1210/jc.2011-1049
- Nuclear mTOR acts as a transcriptional integrator of the androgen signaling pathway in prostate cancer., Giguère V, Aprikian AG, Brimo F, Hamel L, Scarlata E, Bourque G, Caron M, Vernier M, Kalloghlian G, Yan M, Zouanat FZ, Yee T, Dufour CR, Audet-Walsh É, Genes & development, 2017, 10.1101/gad.299958.117
- Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1α/ERRα., Pause A, Giguère V, Baba M, St-Pierre J, Walker B, Dufour CR, Manteghi S, Audet-Walsh É, Yan M, Genes & development, 2016, 10.1101/gad.281410.116
- Glucocorticoids and phenobarbital induce murine CYP2B genes by independent mechanisms., Anderson A, Auclair-Vincent S, Audet-Walsh E, Expert opinion on drug metabolism & toxicology, 2009, 10.1517/17425250903234709
- SREBF1 Activity Is Regulated by an AR/mTOR Nuclear Axis in Prostate Cancer., Giguère V, Chen Y, Li S, Laflamme C, Yee T, Vernier M, Audet-Walsh É, Molecular cancer research : MCR, 2018, 10.1158/1541-7786.mcr-17-0410
- Estrogen-related receptors are targetable ROS sensors., Giguère V, Audet-Walsh E, St-Pierre J, Park M, Kuasne H, Bourmeau G, Li X, Scholtes C, McGuirk S, Dufour CR, Vernier M, Genes & development, 2020, 10.1101/gad.330746.119
- Using Omics to better understand steroid biosynthesis, metabolism, and functions., Lin SX, Wang XQ, Audet-Walsh É, The Journal of steroid biochemistry and molecular biology, 2020, 10.1016/j.jsbmb.2020.105686
- The Longevity Protein Klotho: A Promising Tool to Monitor Lifestyle Improvements, Angelo Tremblay, Alfred-Kodjo Toi, Jean-Philippe Drouin-Chartier, Virginie Blanchette, Etienne Audet-Walsh, Julie-Alexandra Moulin, Pierre Cordeau, Caroline Rhéaume, Jean-Sébastien Paquette, Metabolites, 2023, 10.3390/metabo13111157
- Androgen-Dependent Repression of ERRγ Reprograms Metabolism in Prostate Cancer., Giguère V, St-Pierre J, Ouellet C, Vernier M, McGuirk S, Yee T, Audet-Walsh É, Cancer research, 2016, 10.1158/0008-5472.can-16-1204
- Alternative splicing regulation by the androgen receptor in prostate cancer cells., Audet-Walsh É, Weidmann C, Karthik Poluri RT, Beaudette J, Lafront C, Germain L, The Journal of steroid biochemistry and molecular biology, 2020, 10.1016/j.jsbmb.2020.105710
- Fatty acid oxidation enzyme Δ3, Δ2-enoyl-CoA isomerase 1 (ECI1) drives aggressive tumor phenotype and predicts poor clinical outcome in prostate cancer patients., Lapointe J, Chevalier S, Aprikian AG, Divangahi M, Brimo F, Hamel L, Scarlata E, Pernet E, Kassem O, Rouzbeh S, Audet-Walsh É, Guérard KP, Bramhecha YM, Oncogene, 2022, 10.1038/s41388-022-02276-z
- The CYP2B2 5' flank contains a complex glucocorticoid response unit., Anderson A, Lachaud AA, Audet-Walsh E, Biochemical pharmacology, 2008, 10.1016/j.bcp.2008.08.015
- Role of Secreted Frizzled-Related Protein 1 in Early Breast Carcinogenesis and Breast Cancer Aggressiveness, Francine Durocher, Caroline Diorio, Etienne Audet-Walsh, Annick Michaud, Geneviève Ouellette, Juliette Bherer, Aurélie Lacouture, Alisson Clemenceau, Cancers, 2023, 10.3390/cancers15082251
- Prostate cancer resistance leads to a global deregulation of translation factors and unconventional translation., Hussein SMI, Mazroui R, Toren P, Lambert JP, Audet-Walsh E, Zoubeidi A, Gris T, Paquette V, Grenier St-Sauveur V, Joncas FH, Adjibade P, Khelifi G, Lelong EIJ, NAR cancer, 2022, 10.1093/narcan/zcac034
- UGT2B28 accelerates prostate cancer progression through stabilization of the endocytic adaptor protein HIP1 regulating AR and EGFR pathways., Lévesque E, Aprikian A, Latour M, Barrès V, Ouellet V, Simonyan D, Villeneuve L, Wagner A, Émond JP, Beillevaire D, Mehdi S, Brisson H, Hovington H, Lacombe L, Cancer letters, 2022, 10.1016/j.canlet.2022.215994
- Genomic Deletion at 10q23 in Prostate Cancer: More Than PTEN Loss?, Audet-Walsh É, Poluri RTK, Frontiers in oncology, 2018, 10.3389/fonc.2018.00246
- Inhibition of DNMT1 and ERRα crosstalk suppresses breast cancer via derepression of IRF4., Giguère V, St-Pierre J, Audet-Walsh E, Wan L, Dufour CR, McGuirk S, Vernier M, Oncogene, 2020, 10.1038/s41388-020-01438-1
- RNA sequencing data of human prostate cancer cells treated with androgens., Audet-Walsh É, Droit A, Beauparlant CJ, Poluri RTK, Data in brief, 2019, 10.1016/j.dib.2019.104372
- Molecular markers in key steroidogenic pathways, circulating steroid levels, and prostate cancer progression., Guillemette C, Caron P, Yu CC, Huang CY, Rouleau M, Laverdière I, Fradet Y, Bao BY, Lacombe L, Audet-Walsh É, Huang SP, Lévesque É, Clinical cancer research : an official journal of the American Association for Cancer Research, 2012, 10.1158/1078-0432.ccr-12-2812
- FACS-Free isolation and purification protocol of mouse prostate epithelial cells for organoid primary culture., Jobin C, Audet-Walsh É, Weidmann C, Lacouture A, Frégeau-Proulx L, MethodsX, 2022, 10.1016/j.mex.2022.101843
- Profiling of endogenous estrogens, their precursors, and metabolites in endometrial cancer patients: association with risk and relationship to clinical characteristics., Guillemette C, Bélanger A, Villeneuve L, Brisson J, Ayotte P, Têtu B, Caron P, Plante M, Grégoire J, Lépine J, Audet-Walsh E, The Journal of clinical endocrinology and metabolism, 2010, 10.1210/jc.2010-2050
- Reprogramming of Isocitrate Dehydrogenases Expression and Activity by the Androgen Receptor in Prostate Cancer., Audet-Walsh É, Tadros M, Weidmann C, Poluri RTK, Gonthier K, Molecular cancer research : MCR, 2019, 10.1158/1541-7786.mcr-19-0020
- Preclinical models of prostate cancer - modelling androgen dependency and castration resistance in vitro, ex vivo and in vivo., Audet-Walsh É, Pouliot F, Paquette JS, Neveu B, Paquette V, Lafront C, Germain L, Nature reviews. Urology, 2023, 10.1038/s41585-023-00726-1
Contribution à l'enseignement aux cycles supérieurs
Étudiant(e)s dirigé(e)s*
Depuis 2009- Lucas Germain - Doctorat - En cours
- Mame Sokhna Sylla - Maîtrise avec mémoire - En cours
- Lucas Galey - Maîtrise avec mémoire - En cours
- Camille Lafront - Doctorat - En cours
- Alice Fradet - Doctorat - En cours
- Heitor Cappato Guerra Silva - Doctorat - En cours
- Maxime Yves Gérard Labroy - Maîtrise avec mémoire - En cours
- Louis Olivier Francois Freville - Maîtrise avec mémoire - En cours
- Aurélie Grange - Doctorat - En cours
- Aurélie Lacouture - Doctorat - En cours
- Dina Irsenco - Maîtrise avec mémoire - En cours
- Xiaoye Sang - Doctorat - 2019/09
- Raghavendra Tejo Karthik Poluri - Maîtrise avec mémoire - 2020/05
- Virginie Paquette - Maîtrise avec mémoire - 2022/05
- Lilianne Frégeau-Proulx - Maîtrise avec mémoire - 2022/09
- Marie-Kim St-Pierre - Doctorat - 2023/05
- Kevin Gonthier - Doctorat - 2023/05
- Cynthia Jobin - Maîtrise avec mémoire - 2024/01
Encadrement d'étudiant(e)s
Direction de recherche dans les domaines suivants :
- Médecine moléculaire
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