Découvrez nos professeurs et professeures!

Revenir au répertoire
Fiche précédente
Fiche suivante

Étienne Audet-Walsh

Professeur agrégé

Étienne Audet-Walsh
etienne.audet-walsh.1@ulaval.ca
Centre de recherche sur le cancer
Centre de recherche en reproduction, développement et santé intergénérationnelle
Centre de recherche du CHU de Québec - Université Laval
Partager la fiche :

Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Oncologie

Domaines et intérêts de recherche du (de la) professeur(e) :

Cancer
  • Apoptose et cancer
  • Cancer la prostate
  • Cancer de l'appareil reproducteur
  • Cancer du sein
  • Cancers hormonaux-dépendants
  • Carcinogénèse
Nutrition et métabolisme
Cellulaire
Génomique et protéomique

Projets de recherche

  • Unravelling the role of primary cilia in prostate cancer initiation and progression - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2023-04-01 au 2028-03-31
  • Understanding mitochondrial metabolism to identify prostate cancer metabolic vulnerabilities - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2022-10-01 au 2027-09-30
  • Mitochondria bound to lipid droplets as new regulators of insulin resistance - Diabète Canada - Subvention de fonctionnement : Mettre fin au diabète prix 2022, co-chercheur - 2022-12-01 au 2025-11-30
  • Canada Research Chair in Targeting metabolic vulnerabilities for the treatment of hormone-sensitive cancers - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2020-07-01 au 2025-06-30
  • Regulation of Cellular Energy Metabolism in Mammary Epithelial Cells - Conseil de recherches en sciences naturelles et génie Canada, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2019-04-01 au 2024-03-31
  • Génomique fonctionnelle des récepteurs aux hormones stéroïdiennes dans le contrôle du métabolisme énergétique des cellules de cancer de la prostate - Fonds de recherche du Québec - Santé - Établissement de jeunes chercheurs - Juniors 1, chercheur principal - 2019-07-01 au 2023-06-30
  • Functional interaction between the androgen and the estrogen signalling pathways in prostate cancer - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2018-10-01 au 2023-03-31
  • ABCB10 reprograms mitochondria in pro-inflammatory macrophages of obese mice - CHU de Québec – Université Laval – CHUL - Subvention de fonctionnement de centre, co-chercheur - 2022-09-21 au 2023-03-31
  • Caractérisation du protéome mitochondrial de la prostate - CHU de Québec – Université Laval – CHUL - Subvention de fonctionnement de centre, chercheur principal - 2022-09-21 au 2023-03-31
  • What are my options? A feasibility study of a personalized primary prevention strategy for women and men at high risk of breast and prostate cancer - Instituts de recherche en santé du Canada, Fondation du cancer du sein du Québec, Société canadienne du cancer - Initiative SCC/IC-IRSC en prévention primaire du cancer, co-chercheur - 2022-01-15 au 2023-01-14
  • Utilisation du dosage du citrate pour le dépistage du cancer de la prostate - Fondation du CHU de Québec, chercheur principal - 2021-11-15 au 2022-11-14
  • Inhibition of the AMPK metabolic program for the treatment of prostate cancer - L'Institut de recherche de la Société canadienne du cancer - Subventions pour l'innovation, chercheur principal - 2019-08-01 au 2022-07-31
  • Bourse de soutien aux nouveaux détenteurs de Chaire de recherche du Canada - Université Laval - Fonds internes - Fonds de soutien aux professeurs-chercheurs bénéficiant d’une Chaire de recherche du Canada, chercheur principal - 2020-07-01 au 2022-06-30
  • Étude de criblage sur la reprogrammation du métabolisme, du micro-environnement tumoral et des cellules souches cancéreuses dans le médulloblastome - Université Laval - Fonds internes - BDR - Contributions, chercheur principal - 2021-05-01 au 2022-04-30
  • Targeting metabolic vulnerabilities for the treatment of prostate cancer - Fondation Canadienne pour l'innovation (La), Ministère de la Santé et des Services sociaux - Fonds des leaders John-R.-Evans (FLJR), chercheur principal - 2019-07-01 au 2021-12-31
  • Deciphering the role of KLF5 and NFYA in prostate cancer - Instituts de recherche en santé du Canada, Société de recherche sur le cancer - Subvention de fonctionnement, chercheur principal - 2018-09-01 au 2021-03-31

Publications

  • Role of Secreted Frizzled-Related Protein 1 in Early Breast Carcinogenesis and Breast Cancer Aggressiveness, Alisson Clemenceau, Aurélie Lacouture, Juliette Bherer, Geneviève Ouellette, Annick Michaud, Etienne Audet-Walsh, Caroline Diorio, Francine Durocher, Cancers, 2023, 10.3390/cancers15082251
  • Preclinical models of prostate cancer - modelling androgen dependency and castration resistance in vitro, ex vivo and in vivo., Germain L, Lafront C, Paquette V, Neveu B, Paquette JS, Pouliot F, Audet-Walsh É, Nature reviews. Urology, 2023, 10.1038/s41585-023-00726-1
  • Prostate cancer resistance leads to a global deregulation of translation factors and unconventional translation., Lelong EIJ, Khelifi G, Adjibade P, Joncas FH, Grenier St-Sauveur V, Paquette V, Gris T, Zoubeidi A, Audet-Walsh E, Lambert JP, Toren P, Mazroui R, Hussein SMI, NAR cancer, 2022, 10.1093/narcan/zcac034
  • UGT2B28 accelerates prostate cancer progression through stabilization of the endocytic adaptor protein HIP1 regulating AR and EGFR pathways., Lacombe L, Hovington H, Brisson H, Mehdi S, Beillevaire D, Émond JP, Wagner A, Villeneuve L, Simonyan D, Ouellet V, Barrès V, Latour M, Aprikian A, Lévesque E, Cancer letters, 2022, 10.1016/j.canlet.2022.215994
  • FACS-Free isolation and purification protocol of mouse prostate epithelial cells for organoid primary culture., Frégeau-Proulx L, Lacouture A, Weidmann C, Jobin C, Audet-Walsh É, MethodsX, 2022, 10.1016/j.mex.2022.101843
  • Integrated multi-omics analysis of adverse cardiac remodeling and metabolic inflexibility upon ErbB2 and ERRα deficiency., Dufour CR, Xia H, B'chir W, Perry MC, Kuzmanov U, Gainullina A, Dejgaard K, Scholtes C, Ouellet C, Zuo D, Sanguin-Gendreau V, Guluzian C, Smith HW, Giguère V, Communications biology, 2022, 10.1038/s42003-022-03942-4
  • Low expression of PGC-1β and other mitochondrial biogenesis modulators in melanoma is associated with growth arrest and the induction of an immunosuppressive gene expression program dependent on MEK and IRF-1., Laurin KM, Coutu-Beaudry K, Salazar A, Méribout N, Audet-Walsh É, Gravel SP, Cancer letters, 2022, 10.1016/j.canlet.2022.215738
  • Multiple metabolic pathways fuel the truncated tricarboxylic acid cycle of the prostate to sustain constant citrate production and secretion., Frégeau-Proulx L, Lacouture A, Berthiaume L, Weidmann C, Harvey M, Gonthier K, Pelletier JF, Neveu B, Jobin C, Bastien D, Bergeron A, Fradet Y, Audet-Walsh É, Molecular metabolism, 2022, 10.1016/j.molmet.2022.101516
  • Fatty acid oxidation enzyme Δ3, Δ2-enoyl-CoA isomerase 1 (ECI1) drives aggressive tumor phenotype and predicts poor clinical outcome in prostate cancer patients., Bramhecha YM, Guérard KP, Audet-Walsh É, Rouzbeh S, Kassem O, Pernet E, Scarlata E, Hamel L, Brimo F, Divangahi M, Aprikian AG, Chevalier S, Lapointe J, Oncogene, 2022, 10.1038/s41388-022-02276-z
  • A Nutrient-Based Cellular Model to Characterize Acetylation-Dependent Protein-Protein Interactions., Loehr J, Kougnassoukou Tchara PE, Gonthier K, Noufi C, Linteau N, Audet-Walsh É, Lambert JP, Frontiers in molecular biosciences, 2022, 10.3389/fmolb.2022.831758
  • Loss of hepatic Flcn protects against fibrosis and inflammation by activating autophagy pathways., Paquette M, Yan M, Ramírez-Reyes JMJ, El-Houjeiri L, Biondini M, Dufour CR, Jeong H, Pacis A, Giguère V, Estall JL, Siegel PM, Audet-Walsh É, Pause A, Scientific reports, 2021, 10.1038/s41598-021-99958-7
  • Impacts of endocrine-disrupting chemicals on prostate function and cancer., Lacouture A, Lafront C, Peillex C, Pelletier M, Audet-Walsh É, Environmental research, 2021, 10.1016/j.envres.2021.112085
  • A FACS-Free Purification Method to Study Estrogen Signaling, Organoid Formation, and Metabolic Reprogramming in Mammary Epithelial Cells., Lacouture A, Jobin C, Weidmann C, Berthiaume L, Bastien D, Laverdière I, Pelletier M, Audet-Walsh É, Frontiers in endocrinology, 2021, 10.3389/fendo.2021.672466
  • KLF5 and NFYA factors as novel regulators of prostate cancer cell metabolism., Poluri RTK, Paquette V, Allain ÉP, Lafront C, Joly-Beauparlant C, Weidmann C, Droit A, Guillemette C, Pelletier M, Audet-Walsh É, Endocrine-related cancer, 2021, 10.1530/erc-20-0504
  • Inhibition of DNMT1 and ERRα crosstalk suppresses breast cancer via derepression of IRF4., Vernier M, McGuirk S, Dufour CR, Wan L, Audet-Walsh E, St-Pierre J, Giguère V, Oncogene, 2020, 10.1038/s41388-020-01438-1
  • Alternative splicing regulation by the androgen receptor in prostate cancer cells., Germain L, Lafront C, Beaudette J, Karthik Poluri RT, Weidmann C, Audet-Walsh É, The Journal of steroid biochemistry and molecular biology, 2020, 10.1016/j.jsbmb.2020.105710
  • Using Omics to better understand steroid biosynthesis, metabolism, and functions., Audet-Walsh É, Wang XQ, Lin SX, The Journal of steroid biochemistry and molecular biology, 2020, 10.1016/j.jsbmb.2020.105686
  • A Systematic Study of the Impact of Estrogens and Selective Estrogen Receptor Modulators on Prostate Cancer Cell Proliferation., Lafront C, Germain L, Weidmann C, Audet-Walsh É, Scientific reports, 2020, 10.1038/s41598-020-60844-3
  • Alternative promoters control UGT2B17-dependent androgen catabolism in prostate cancer and its influence on progression., Lévesque E, Labriet A, Hovington H, Allain ÉP, Melo-Garcia L, Rouleau M, Brisson H, Turcotte V, Caron P, Villeneuve L, Leclercq M, Droit A, Guillemette C, British journal of cancer, 2020, 10.1038/s41416-020-0749-2
  • Estrogen-related receptors are targetable ROS sensors., Vernier M, Dufour CR, McGuirk S, Scholtes C, Li X, Bourmeau G, Kuasne H, Park M, St-Pierre J, Audet-Walsh E, Giguère V, Genes & development, 2020, 10.1101/gad.330746.119
  • Editorial: AMPK and mTOR Beyond Signaling: Emerging Roles in Transcriptional Regulation., Audet-Walsh É, Vernier M, Viollet B, Frontiers in cell and developmental biology, 2020, 10.3389/fcell.2020.641552
  • RNA sequencing data of human prostate cancer cells treated with androgens., Poluri RTK, Beauparlant CJ, Droit A, Audet-Walsh É, Data in brief, 2019, 10.1016/j.dib.2019.104372
  • Reprogramming of Isocitrate Dehydrogenases Expression and Activity by the Androgen Receptor in Prostate Cancer., Gonthier K, Poluri RTK, Weidmann C, Tadros M, Audet-Walsh É, Molecular cancer research : MCR, 2019, 10.1158/1541-7786.mcr-19-0020
  • Functional genomic studies reveal the androgen receptor as a master regulator of cellular energy metabolism in prostate cancer., Gonthier K, Poluri RTK, Audet-Walsh É, The Journal of steroid biochemistry and molecular biology, 2019, 10.1016/j.jsbmb.2019.04.016
  • Genomic Deletion at 10q23 in Prostate Cancer: More Than PTEN Loss?, Poluri RTK, Audet-Walsh É, Frontiers in oncology, 2018, 10.3389/fonc.2018.00246
  • SREBF1 Activity Is Regulated by an AR/mTOR Nuclear Axis in Prostate Cancer., Audet-Walsh É, Vernier M, Yee T, Laflamme C, Li S, Chen Y, Giguère V, Molecular cancer research : MCR, 2018, 10.1158/1541-7786.mcr-17-0410
  • Nuclear mTOR acts as a transcriptional integrator of the androgen signaling pathway in prostate cancer., Audet-Walsh É, Dufour CR, Yee T, Zouanat FZ, Yan M, Kalloghlian G, Vernier M, Caron M, Bourque G, Scarlata E, Hamel L, Brimo F, Aprikian AG, Giguère V, Genes & development, 2017, 10.1101/gad.299958.117
  • Inverse Regulation of DHT Synthesis Enzymes 5α-Reductase Types 1 and 2 by the Androgen Receptor in Prostate Cancer., Audet-Walsh É, Yee T, Tam IS, Giguère V, Endocrinology, 2017, 10.1210/en.2016-1926
  • Androgen-Dependent Repression of ERRγ Reprograms Metabolism in Prostate Cancer., Audet-Walsh É, Yee T, McGuirk S, Vernier M, Ouellet C, St-Pierre J, Giguère V, Cancer research, 2016, 10.1158/0008-5472.can-16-1204
  • Correlation between prostate volume and single nucleotide polymorphisms implicated in the steroid pathway., Cornu JN, Audet-Walsh E, Drouin S, Bigot P, Valeri A, Fournier G, Azzouzi AR, Roupret M, Cormier L, Chanock S, Guillemette C, Cussenot O, Lévesque E, Cancel-Tassin G, World journal of urology, 2016, 10.1007/s00345-016-1869-4
  • Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1α/ERRα., Yan M, Audet-Walsh É, Manteghi S, Dufour CR, Walker B, Baba M, St-Pierre J, Giguère V, Pause A, Genes & development, 2016, 10.1101/gad.281410.116
  • The PGC-1α/ERRα Axis Represses One-Carbon Metabolism and Promotes Sensitivity to Anti-folate Therapy in Breast Cancer., Audet-Walsh É, Papadopoli DJ, Gravel SP, Yee T, Bridon G, Caron M, Bourque G, Giguère V, St-Pierre J, Cell reports, 2016, 10.1016/j.celrep.2015.12.086
  • The multiple universes of estrogen-related receptor α and γ in metabolic control and related diseases., Audet-Walsh É, Giguére V, Acta pharmacologica Sinica, 2014, 10.1038/aps.2014.121
  • The UGT1 locus is a determinant of prostate cancer recurrence after prostatectomy., Laverdière I, Flageole C, Audet-Walsh É, Caron P, Fradet Y, Lacombe L, Lévesque É, Guillemette C, Endocrine-related cancer, 2014, 10.1530/erc-14-0423
  • Steroidogenic germline polymorphism predictors of prostate cancer progression in the estradiol pathway., Lévesque E, Laverdière I, Audet-Walsh E, Caron P, Rouleau M, Fradet Y, Lacombe L, Guillemette C, Clinical cancer research : an official journal of the American Association for Cancer Research, 2014, 10.1158/1078-0432.ccr-13-2567
  • Molecular markers in key steroidogenic pathways, circulating steroid levels, and prostate cancer progression., Lévesque É, Huang SP, Audet-Walsh É, Lacombe L, Bao BY, Fradet Y, Laverdière I, Rouleau M, Huang CY, Yu CC, Caron P, Guillemette C, Clinical cancer research : an official journal of the American Association for Cancer Research, 2012, 10.1158/1078-0432.ccr-12-2812
  • The impact of germline genetic variations in hydroxysteroid (17-beta) dehydrogenases on prostate cancer outcomes after prostatectomy., Audet-Walsh É, Bellemare J, Lacombe L, Fradet Y, Fradet V, Douville P, Guillemette C, Lévesque É, European urology, 2011, 10.1016/j.eururo.2011.12.021
  • Deletions of the androgen-metabolizing UGT2B genes have an effect on circulating steroid levels and biochemical recurrence after radical prostatectomy in localized prostate cancer., Nadeau G, Bellemare J, Audet-Walsh É, Flageole C, Huang SP, Bao BY, Douville P, Caron P, Fradet Y, Lacombe L, Guillemette C, Lévesque E, The Journal of clinical endocrinology and metabolism, 2011, 10.1210/jc.2011-1049
  • SRD5A polymorphisms and biochemical failure after radical prostatectomy., Audet-Walsh E, Bellemare J, Nadeau G, Lacombe L, Fradet Y, Fradet V, Huang SP, Bao BY, Douville P, Girard H, Guillemette C, Lévesque E, European urology, 2011, 10.1016/j.eururo.2011.06.020
  • Profiling of endogenous estrogens, their precursors, and metabolites in endometrial cancer patients: association with risk and relationship to clinical characteristics., Audet-Walsh E, Lépine J, Grégoire J, Plante M, Caron P, Têtu B, Ayotte P, Brisson J, Villeneuve L, Bélanger A, Guillemette C, The Journal of clinical endocrinology and metabolism, 2010, 10.1210/jc.2010-2050
  • Circulating estrogens in endometrial cancer cases and their relationship with tissular expression of key estrogen biosynthesis and metabolic pathways., Lépine J, Audet-Walsh E, Grégoire J, Têtu B, Plante M, Ménard V, Ayotte P, Brisson J, Caron P, Villeneuve L, Bélanger A, Guillemette C, The Journal of clinical endocrinology and metabolism, 2010, 10.1210/jc.2010-2648
  • Glucocorticoids and phenobarbital induce murine CYP2B genes by independent mechanisms., Audet-Walsh E, Auclair-Vincent S, Anderson A, Expert opinion on drug metabolism & toxicology, 2009, 10.1517/17425250903234709
  • Profiling endogenous serum estrogen and estrogen-glucuronides by liquid chromatography-tandem mass spectrometry., Caron P, Audet-Walsh E, Lépine J, Bélanger A, Guillemette C, Analytical chemistry, 2009, 10.1021/ac9019126
  • Werner's syndrome helicase participates in transcription of phenobarbital-inducible CYP2B genes in rat and mouse liver., Lachaud AA, Auclair-Vincent S, Massip L, Audet-Walsh E, Lebel M, Anderson A, Biochemical pharmacology, 2009, 10.1016/j.bcp.2009.09.002
  • Dexamethasone induction of murine CYP2B genes requires the glucocorticoid receptor., Audet-Walsh E, Anderson A, Drug metabolism and disposition: the biological fate of chemicals, 2008, 10.1124/dmd.108.022772
  • The CYP2B2 5' flank contains a complex glucocorticoid response unit., Audet-Walsh E, Lachaud AA, Anderson A, Biochemical pharmacology, 2008, 10.1016/j.bcp.2008.08.015

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Camille Lafront - Doctorat - En cours
  • Lucas Germain - Doctorat - En cours
  • Cynthia Jobin - Maîtrise avec mémoire - En cours
  • Aurélie Lacouture - Doctorat - En cours
  • Lucas Galey - Maîtrise avec mémoire - En cours
  • Heitor Cappato Guerra Silva - Doctorat - En cours
  • Oussama Boulfiza - Doctorat - En cours
  • Kevin Gonthier - Doctorat - En cours
  • Marie-Kim St-Pierre - Doctorat - En cours
  • Xiaoye Sang - Doctorat - 2019/09
  • Raghavendra Tejo Karthik Poluri - Maîtrise avec mémoire - 2020/05
  • Virginie Paquette - Maîtrise avec mémoire - 2022/05
  • Lilianne Frégeau-Proulx - Maîtrise avec mémoire - 2022/09

Encadrement d'étudiant(e)s pour les programmes suivants :

Disponibilité d'encadrement d'étudiant(e)s

Ce (cette) professeur(e) est présentement à la recherche d'étudiant(e)s.

Envoyer un courriel
*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
Mettre à jour mon profil de professeur(e)