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Darren Edward Richard

Professeur titulaire

Darren Edward Richard
Centre de recherche sur le cancer
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Oncologie
Santé cardiovasculaire, respiratoire et métabolisme

Domaines et intérêts de recherche du (de la) professeur(e) :

Cancer
Santé circulatoire et respiratoire
  • Anémies
  • Angiogénèse
  • Hypertension artérielle
  • Maladies cardiovasculaires
  • Signalisation cellulaire

Projets de recherche

  • Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
  • Use of nanoparticles to understand and treat vascular calcification in chronic kidney disease - Fondation canadienne du rein, co-chercheur - 2020-10-01 au 2022-09-30
  • Novel Interactions and Functions for Hypoxia-Inducible Factor-1 (HIF-1) during Vascular Responses - Fondation de l'Université Laval, chercheur principal - 2016-04-01 au 2022-03-31
  • Cardiovascular and renal therapeutic effects of the ferric pyrophosphate citrate (FPC) Triferic® in rats with chronic kidney disease - Rockwell Medical, co-chercheur - 2020-09-09 au 2021-10-31
  • Proline hydroxylase inhibitors: linking HIF-1 to arterial calcification - Fondation canadienne du rein - Subvention de soutien à la recherche biomédicale, chercheur principal - 2019-07-01 au 2021-09-30

Publications

  • Targeting Axl favors an antitumorigenic microenvironment that enhances immunotherapy responses by decreasing Hif-1α levels, Marie-Anne Goyette, Islam E. Elkholi, Chloé Apcher, Hellen Kuasne, Carla V. Rothlin, William J. Muller, Darren E. Richard, Morag Park, Jean-Philippe Gratton, Jean-François Côté, Proceedings of the National Academy of Sciences, 2021, 10.1073/pnas.2023868118
  • The adenoviral protein E4orf4: a probing tool to decipher mechanical stress-induced nuclear envelope remodeling in tumor cells, Kévin Jacquet, Marc-Antoine Rodrigue, Darren E. Richard, Josée N. Lavoie, Cell Cycle, 2020, 10.1080/15384101.2020.1836441
  • Adenoviral protein E4orf4 interacts with the polarity protein Par3 to induce nuclear rupture and tumor cell death, Claire Dziengelewski, Marc-Antoine Rodrigue, Alexia Caillier, Kévin Jacquet, Marie-Chloé Boulanger, Jonathan Bergeman, Margit Fuchs, Herman Lambert, Patrick Laprise, Darren E. Richard, François Bordeleau, Marc-Étienne Huot, Josée N. Lavoie, Journal of Cell Biology, 2020, 10.1083/jcb.201805122
  • Endothelin type A receptor blockade reduces vascular calcification and inflammation in rats with chronic kidney disease, Lariviere, R., Gauthier-Bastien, A., Ung, R.-V., St-Hilaire, J., Mac-Way, F., Richard, D.E., Agharazii, M., Journal of Hypertension, 2017, 10.1097/HJH.0000000000001161
  • Selective HIF-1 regulation under nonhypoxic conditions by the p42/p44 MAP kinase inhibitor PD184161, Jalouli, M., Mokas, S., Turgeon, C.A., Lamalice, L., Richard, D.E., Molecular Pharmacology, 2017, 10.1124/mol.117.108654
  • A role for hypoxia-inducible factor-1 (HIF-1) in phosphate-induced vascular smooth muscle cell calcification, , Kidney International (In Press), 2016
  • Hypoxia-inducible factor-1 plays a role in phosphate-induced vascular smooth muscle cell calcification, Mokas, S., Larivière, R., Lamalice, L., Gobeil, S., Cornfield, D.N., Agharazii, M., Richard, D.E., Kidney International, 2016, 10.1016/j.kint.2016.05.020
  • Inflammatory cytokines and reactive oxygen species as mediators of chronic kidney disease-related vascular calcification, Agharazii, M., St-Louis, R., Gautier-Bastien, A., Ung, R.-V., Mokas, S., Larivière, R., Richard, D.E., American Journal of Hypertension, 2015, 10.1093/ajh/hpu225
  • The prolyl isomerase Pin1 regulates hypoxia-inducible transcription factor (HIF) activity, Jalouli, M., Déry, M.A.C., Lafleur, V.N., Lamalice, L., Zhou, X.Z., Lu, K.P., Richard, D.E., 2014, 10.1016/j.cellsig.2014.04.005
  • Transcriptional repression of hypoxia-inducible factor-1 (HIF-1) by the protein arginine methyltransferase PRMT1, Lafleur, V.N., Richard, S., Richard, D.E., Molecular Biology of the Cell, 2014, 10.1091/mbc.E13-07-0423
  • Conserved molecular interactions within the HBO1 acetyltransferase complexes regulate cell proliferation, Avvakumov, N., Lalonde, M.-E., Saksouk, N., Paquet, E., Glass, K.C., Landry, A.-J., Doyon, Y., Cayrou, C., Robitaille, G.A., Richard, D.E., Yang, X.-J., Kutateladze, T.G., Côté, J., Molecular and Cellular Biology, 2012, 10.1128/MCB.06455-11
  • The Werner syndrome gene product (WRN): A repressor of hypoxia-inducible factor-1 activity, Labbé, A., Lafleur, V.N., Patten, D.A., Robitaille, G.A., Garand, C., Lamalice, L., Lebel, M., Richard, D.E., Experimental Cell Research, 2012, 10.1016/j.yexcr.2012.04.010
  • Effects of TGF-β1 on endothelial factors, Cellier, E., Midaoui, A.E., Robitaille, G.A., Richard, D.E., Larivire, R., Lebel, M., Archives of Physiology and Biochemistry, 2010, 10.3109/13813451003610862
  • HIF-1 inhibition decreases systemic vascular remodelling diseases by promoting apoptosis through a hexokinase 2-dependent mechanism, Lambert, C.M., Roy, M., Robitaille, G.A., Richard, D.E., Bonnet, S., Continuing Education in Anaesthesia, Critical Care and Pain, 2010
  • HIF-1 inhibition decreases systemic vascular remodelling diseases by promoting apoptosis through a hexokinase 2-dependent mechanism, Lambert, C.M., Roy, M., Robitaille, G.A., Richard, D.E., Bonnet, S., Cardiovascular Research, 2010, 10.1093/cvr/cvq152
  • Hypoxia-inducible factor-1 activation in nonhypoxic conditions: The essential role of mitochondrial-derived reactive oxygen species, Patten, D.A., Lafleur, V.N., Robitaille, G.A., Chan, D.A., Giaccia, A.J., Richard, D.E., Molecular Biology of the Cell, 2010, 10.1091/mbc.E10-01-0025
  • Tumor necrosis factor inhibitors as novel therapeutic tools for vascular remodeling diseases, Lambert, C.M., Roy, M., Meloche, J., Robitaille, G.A., Agharazii, M., Richard, D.E., Bonnet, S., American Journal of Physiology - Heart and Circulatory Physiology, 2010, 10.1152/ajpheart.00562.2010
  • Sphingosine-1-phosphate: A novel nonhypoxic activator of hypoxia-inducible factor-1 in vascular cells, Michaud, M.D., Robitaille, G.A., Gratton, J.-P., Richard, D.E., Arteriosclerosis, Thrombosis, and Vascular Biology, 2009, 10.1161/ATVBAHA.109.185280
  • TGFβ-induced GRK2 expression attenuates AngII-regulated vascular smooth muscle cell proliferation and migration, Guo, J., Chen, H., Ho, J., Mancini, J., Sontag, T., Laporte, S.A., Richard, D.E., Lebrun, J.-J., Cellular Signalling, 2009, 10.1016/j.cellsig.2009.01.037
  • (2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide (BiPS), a matrix metalloprotease inhibitor, is a novel and potent activator of hypoxia-inducible factors, Lauzier, M.-C., Robitaille, G.A., Chan, D.A., Giaccia, A.J., Richard, D.E., Molecular Pharmacology, 2008, 10.1124/mol.108.045690
  • Hypoxia-inducible factor-1α stabilization in nonhypoxic conditions: Role of oxidation and intracellular ascorbate depletion, Page, E.L., Chan, D.A., Giaccia, A.J., Levine, M., Richard, D.E., Molecular Biology of the Cell, 2008, 10.1091/mbc.E07-06-0612
  • Differential regulation of hypoxia-inducible factor-1 through receptor tyrosine kinase transactivation in vascular smooth muscle cells, Lauzier, M.-C., Pagé, E.L., Michaud, M.D., Richard, D.E., Endocrinology, 2007, 10.1210/en.2007-0285
  • Erratum: Arrest-defective-1 protein, an acetyltransferase, does not alter stability of hypoxia-inducible factor (HIF)-1α and is not induced by hypoxia or HIF (Journal of Biological Chemistry (2005) 280 (31132-31140)), Bilton, R., Brahimi-Horn, M.C., Déry, M.-A., Hattab, M., Mazure, N., Pouysségur, J., Richard, D.E., Trottier, E., Journal of Biological Chemistry, 2006
  • HIF-1 activation during tumor progression: Implications and consequences | Activation de HIF1 dans le cancer: Implications et conséquences, Déry, M.-A.C., Lauzier, M.-C., Michaud, M.D., Richard, D.E., Bulletin du Cancer, 2006
  • Transforming growth factor β1 induces hypoxia-inducible factor-1 stabilization through selective inhibition of PHD2 expression, McMahon, S., Charbonneau, M., Grandmont, S., Richard, D.E., Dubois, C.M., Journal of Biological Chemistry, 2006, 10.1074/jbc.M604507200
  • Arrest-defective-1 protein, an acetyltransferase, does not alter stability of hypoxia-inducible factor (HIF)-1α and is not induced by hypoxia or HIF, Bilton, R., Mazure, N., Trottier, E., Hattab, M., Déry, M.-A., Richard, D.E., Pouysségur, J., Brahimi-Horn, M.C., Journal of Biological Chemistry, 2005, 10.1074/jbc.M504482200
  • Hypoxia-enhanced expression of the proprotein convertase furin is mediated by hypoxia-inducible factor-1: Impact on the bioactivation of proproteins, McMahon, S., Grondin, F., McDonald, P.P., Richard, D.E., Dubois, C.M., Journal of Biological Chemistry, 2005, 10.1074/jbc.M413248200
  • Hypoxia-inducible factor 1: Regulation by hypoxic and non-hypoxic activators, Déry, M.-A.C., Michaud, M.D., Richard, D.E., International Journal of Biochemistry and Cell Biology, 2005, 10.1016/j.biocel.2004.08.012
  • Hypoxic gene activation by lipopolysaccharide in macrophages: Implication of hypoxia-inducible factor 1α, Blouin, C.C., Pagé, E.L., Soucy, G.M., Richard, D.E., Blood, 2004, 10.1182/blood-2003-07-2427
  • Induction of hypoxia-inducible factor-1α by transcriptional and translational mechanisms, Pagé, E.L., Robitaille, G.A., Pouysségur, J., Richard, D.E., Journal of Biological Chemistry, 2002, 10.1074/jbc.M209114200
  • Angiogenesis and G-protein-coupled receptors: Signals that bridge the gap, Richard, D.E., Vouret-Craviari, V., Pouysségur, J., Oncogene, 2001, 10.1038/sj.onc.1204193
  • HIF-1-dependent transcriptional activity is required for oxygen-mediated HIF-1α degradation, Berra, E., Richard, D.E., Gothié, E., Pouysségur, J., FEBS Letters, 2001, 10.1016/S0014-5793(01)02159-7
  • Hypoxia-inducible factor-1α (HIF-1 escapes O2-driven proteasomal degradation irrespective of its subcellular localization: Nucleus or cytoplasm, Berra, E., Roux, D., Richard, D.E., Pouysségur, J., EMBO Reports, 2001, 10.1093/embo-reports/kve130
  • Identification of alternative spliced variants of human hypoxia- inducible factor-1α, Gothié, E., Richard, D.E., Berra, E., Pagès, G., Pouysségur, J., Journal of Biological Chemistry, 2000, 10.1074/jbc.275.10.6922
  • Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1α in vascular smooth muscle cells, Richard, D.E., Berra, E., Pouyssegur, J., Journal of Biological Chemistry, 2000, 10.1074/jbc.M003325200
  • Signaling angiogenesis via p42/p44 MAP kinase and hypoxia, Berra, E., Milanini, J., Richard, D.E., Le Gall, M., Viñals, F., Gothié, E., Roux, D., Pagès, G., Pouysségur, J., Biochemical Pharmacology, 2000, 10.1016/S0006-2952(00)00423-8
  • Signaling angiogenesis via p42/p44 MAP kinase cascade, Berra, E., Gothié, E., Milanini, J., Pagès, G., Pouysségur, J., Richard, D.E., Viñals, F., Annals of the New York Academy of Sciences, 2000
  • Angiogenesis: How a tumor adapts to hypoxia, Richard, D.E., Berra, E., Pouysségur, J., Biochemical and Biophysical Research Communications, 1999, 10.1006/bbrc.1999.1889
  • p42/p44 mitogen-activated protein kinases phosphorylate hypoxia- reducible factor (HIF-1α) and enhance the transcriptional activity of HIF-1, Richard, D.E., Berra, E., Gothié, E., Roux, D., Pouysségur, J., Journal of Biological Chemistry, 1999, 10.1074/jbc.274.46.32631
  • Bovine adrenal glomerulosa cells express such a low level of functional B2 receptors that bradykinin does not significantly increase their aldosterone production, Chrétien, L., Richard, D.E., Poirier, S.N., Paitras, M., Guillemette, G., Journal of Endocrinology, 1998, 10.1677/joe.0.1560449
  • Effect of uncoupling agents on AT1 receptor affinity for antagonist analogs of angiotensin II, Chrétien, L., Guillemette, G., Poitras, M., Richard, D.E., Sidibé, A., Receptors and Channels, 1998
  • Desensitization of AT1 receptor-mediated cellular responses requires long term receptor down-regulation in bovine adrenal glomerulosa cells, Bernier, S.G., Guillemette, G., Laporte, S.A., Leduc, R., Richard, D.E., Endocrinology, 1997, 10.1210/en.138.9.3828
  • Desensitization of AT1 receptor-mediated cellular responses requires long term receptor down-regulation in bovine adrenal glomerulosa cells., Richard, D.E., Laporte, S.A., Bernier, S.G., Leduc, R., Guillemette, G., Endocrinology, 1997
  • Desensitization of AT1receptor-mediated cellular responses requires long term receptor down-regulation in bovine adrenal glomerulosa cells, Richard, D.E., Laporte, S.A., Bernier, S.G., Leduc, R., Guillemette, G., Endocrinology, 1997, 10.1210/endo.138.9.5409
  • Stimulation of the angiotensin II type I receptor on bovine adrenal glomerulosa cells activates a temperature-sensitive internalization-recycling pathway, Richard, D.E., Chrétien, L., Caron, M., Guillemette, G., Molecular and Cellular Endocrinology, 1997, 10.1016/S0303-7207(97)00065-8
  • Novel cyclic analogs of angiotensin II with cyclization between positions 5 and 7: Conformational and biological implications, Zhang, W.-J., Nikiforovich, G.V., Pérodin, J., Richard, D.E., Escher, E., Marshall, G.R., Journal of Medicinal Chemistry, 1996, 10.1021/jm9507744
  • The tyrosine within the NPXnY motif of the human angiotensin II type 1 receptor is involved in mediating signal transduction but is not essential for internalization, Escher, E., Guillemette, G., Laporte, S.A., Leduc, R., Richard, D.E., Servant, G., Molecular Pharmacology, 1996
  • Selective interaction of chemical dyes with inositol 1,4,5-trisphosphate recognition sites, Bernier, S., Boulay, G., Guillemette, G., Richard, D.E., Canadian Journal of Physiology and Pharmacology, 1994
  • Short-term desensitization of the angiotensin II receptor of bovine adrenal glomerulosa cells corresponds to a shift from a high to a low affinity state, Boulay, G., Chrétien, L., Guillemette, G., Richard, D.E., Endocrinology, 1994, 10.1210/en.135.5.2130
  • Short-term desensitization of the angiotensin II receptor of bovine adrenal glomerulosa cells corresponds to a shift from a high to a low affinity state, Boulay, G., Chrétien, L., Richard, D.E., Guillemettes, G., Endocrinology, 1994, 10.1210/endo.135.5.7956936
  • The high affinity state of inositol 1,4,5-trisphosphate receptor is a functional state, Bernier, S., Boulay, G., Guillemette, G., Poitras, M., Richard, D.E., Servant, M., Journal of Biological Chemistry, 1993
  • The organization of the suprachiasmatic circadian pacemaker of the rat and its regulation by neurotransmitters and modulators., Gillette, M.U., DeMarco, S.J., Ding, J.M., Gallman, E.A., Faiman, L.E., Liu, C., McArthur, A.J., Medanic, M., Richard, D., Tcheng, T.K., 1993

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Chaymae El Alaoui - Post-doctorat - En cours
  • Sophie Mokas - Doctorat - En cours
  • Bruna Santos Fernandes - Maitrîse avec mémoire - En cours
  • Eric Côté - Maitrîse avec mémoire - En cours
  • Hadrien Benk-Fortin - Maitrîse avec mémoire - En cours
  • Arianne Gervais - Maitrîse avec mémoire - En cours
  • Veronique Lafleur - Maitrîse avec mémoire - 2011/05
  • Maroua Jalouli - Doctorat - 2018/05
  • Catherine Turgeon - Maitrîse avec mémoire - 2019/05

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.

Direction et personnes-ressources

Vice-décanat à la recherche et aux études supérieures
Pavillon Ferdinand-Vandry
Université Laval
1050, avenue de la Médecine, local 4645
Québec (Québec) G1V 0A6
Canada

Renseignements - Secrétariat
418 656-2690
vdres@fmed.ulaval.ca

Jacques Simard
Vice-doyen à la recherche et aux études supérieures
vice-doyen.recherche-et-etudes-superieures@fmed.ulaval.ca

Louise Laperrière
Adjointe au vice-doyen à la recherche et aux études supérieures
louise.laperriere@fmed.ulaval.ca 

Volet recherche
Gestion financière
Volet études aux cycles supérieurs