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Caroline Diorio

Professeure titulaire

caroline.diorio@fmed.ulaval.ca
Centre de recherche sur le cancer
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Bioinformatique / données massives (big data)
Médecine régénératrice et médecine moléculaire
Oncologie
Santé des populations et pratiques optimales en santé

Domaines et intérêts de recherche du (de la) professeur(e) :

Cancer
  • Cancer du sein
  • Nutrition et cancer
  • Diagnostic et détection du cancer
  • Cancers hormonaux-dépendants
  • Environnement et cancer
  • Carcinogénèse
  • Stress et cancer
  • Déterminants sociaux du cancer
Génétique humaine
  • Interactions gènes et environnement
  • Télomères
  • Micropuces d'ADN et d'ARN
  • Polymorphisme
  • Génomique
Nutrition et métabolisme
  • Obésité
  • Nutrition
  • Nutriments
  • Hormones et facteurs de croissance
  • Métabolisme des médicaments
Santé des populations
  • Habitudes de vie et santé
  • Pharmaco-épidémiologie
  • Prévention en santé
  • Santé environnementale

Projets de recherche

  • L’AIMZ-938, un nouveau promédicament anticancéreux pour le traitement des cancers du sein humain réfractaires aux traitements actuels et exprimant le cytochrome P450 1A1 - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2021-10-01 au 2026-09-30
  • Management of sleeve gastrectomy failure using single-anastomosis metabolic surgery - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2021-10-01 au 2026-09-30
  • Omega-3 fatty acids in the prevention of breast cancer: role of obesity-related markers in breast tissues - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2018-10-01 au 2026-09-30
  • Salaire d'un professeur - CHU de Québec – Université Laval – Hôpital l'Enfant-Jésus, chercheur principal - 2010-07-01 au 2025-06-30
  • Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
  • Vers des trajectoires de soins en cancer du sein personnalisées en fonction du risque et des besoins des patientes: une étude de faisabilité et d'acceptabilité - Fonds de recherche du Québec - Santé, co-chercheur - 2023-04-01 au 2025-03-31
  • Effect of environmental contaminants and methylome of breast adipose tissue on aromatase inhibitor efficacy in breast cancer - Instituts de recherche en santé du Canada - Volet Projet: Concours pilotes, chercheur principal - 2016-07-01 au 2024-09-30
  • The effect of cannabinoid receptors on breast cancer survival - Fondation du cancer du sein du Québec, Société de recherche sur le cancer - Subvention de fonctionnement, chercheur principal - 2022-09-01 au 2024-08-31
  • Tumor biobanking was supported...Fondation du cancer du sein du Québec and the Banque de tissus...of the Réseau...(RRCancer)...by the Oncopole, the FRQS cancer hub,...Ministère de l'Économie, de l'Innovation et de l'Énergie du Québec. - Fonds de recherche du Québec - Santé - ONCOPOLE EMC2: Équipes multi-institutionnelles contre le cancer, chercheur principal - 2023-04-01 au 2024-03-31
  • TBC1D9: therapeutic target of the aggressiveness of triple negative breast cancer - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2023-03-01 au 2024-02-29
  • Deciphering the role of FGD5 during breast cancer progression - Fondation de l'Université Laval, co-chercheur - 2021-05-01 au 2023-04-30
  • Breast adipocyte hypertrophy: a novel biomarker to predict breast cancer survival - American Institute for Cancer Research - Subvention de fonctionnement, chercheur principal - 2022-01-01 au 2023-03-31
  • What are my options? A feasibility study of a personalized primary prevention strategy for women and men at high risk of breast and prostate cancer - Instituts de recherche en santé du Canada, Fondation du cancer du sein du Québec, Société canadienne du cancer - Initiative SCC/IC-IRSC en prévention primaire du cancer, co-chercheur - 2022-01-15 au 2023-01-14
  • Banque de tissu Sein-Ovaire - Fonds de recherche du Québec - Santé - Réseaux thématiques de recherche, chercheur principal - 2000-01-01 au 2021-09-30
  • Design for Better Health: User-Centred Design and Evaluation of Interactive Media for Health Education, Communication and Decision-Making - Instituts de recherche en santé du Canada - Subventions Fondation, co-chercheur - 2016-07-01 au 2021-06-30
  • Deciphering breast cancer HER2-negativity with regard to HER2-targeted therapy - Instituts de recherche en santé du Canada - Volet Projet: Concours pilotes, co-chercheur - 2016-07-01 au 2021-06-30
  • Axe banque de tissus et de données BTD - Fondation du cancer du sein du Québec, chercheur principal - 2011-04-01 au 2021-03-31

Publications

  • Omega-3 fatty acids survey in men under active surveillance for prostate cancer: from intake to prostate tissue level, Fradet, V., Julien, P., Lamarche, B., Têtu, B., Desmeules, P., Diorio, C., Gevariya, N., Moreel, X., Pelletier, J., Allaire, J., Guertin, M., Robitaille, K., Nguile-Makao, M., Moussa, H., Nutrients, 2019, 10.3390/nu11071616
  • Body-mass index and metastatic melanoma outcomes, Diorio, C., Talbot, D., Guertin, J.R., Nabi, H., The Lancet Oncology, 2018, 10.1016/S1470-2045(18)30287-0
  • Characteristics and long-term survival of patients diagnosed with pure tubular carcinoma of the breast, Provencher, L., Hogue, J.-C., Diorio, C., Doyle, C., Lemieux, J., Jacob, S., Boudreau, D., Poirier, B., Desbiens, C., Poirier, É., Journal of Surgical Oncology, 2018, 10.1002/jso.24944
  • Identifying Clinicopathological Factors Associated with Oncotype DX® 21-Gene Recurrence Score: A Real-World Retrospective Cohort Study of Breast Cancer Patients in Quebec City, Canada, Hermann Nabi, Julie Lemieux, Claudya Morin, Julie Lapointe, Cynthia Mbuya-Bienge, Louise Provencher, Caroline Diorio, Simon Gagnet, Journal of Personalized Medicine, 2021, 10.3390/jpm11090858
  • Estrogens and glucocorticoids in mammary adipose tissue: Relationships with body mass index and breast cancer features, Tchernof, A., Andrew, R., Diorio, C., Homer, N.Z.M., Durocher, F., Walker, B.R., Nguyen, S., Poirier, B., Denver, N., Pelletier, M., Laforest, S., Journal of Clinical Endocrinology and Metabolism, 2020, 10.1210/clinem/dgz268
  • Association between local inflammation and breast tissue age-related lobular involution among premenopausal and postmenopausal breast cancer patients, Diorio, C., Poirier, B., Bureau, A., Sanschagrin, F., Têtu, B., Jacob, S., Orain, M., Dumas, I., Hanna, M., PLoS ONE, 2017, 10.1371/journal.pone.0183579
  • Body mass index and clinical outcomes in trastuzumab-treated metastatic breast cancer patients: An alternative explanation for the lack of association, Diorio, C., Nabi, H., Breast, 2018, 10.1016/j.breast.2018.02.030
  • Dairy food consumption and mammographic breast density: The role of fat, Diorio, C., Canitrot, E., Anticancer Research, 2019, 10.21873/anticanres.13828
  • Associations of Biomarkers of Inflammation and Breast Cancer in the Breast Adipose Tissue of Women with Combined Measures of Adiposity, Caroline Diorio, Francine Durocher, André Tchernof, Sue-Ling Chang, Journal of Obesity, 2021, 10.1155/2021/3620147
  • Simultaneous quantification of estrogens and glucocorticoids in human adipose tissue by liquid-chromatography-tandem mass spectrometry, Andrew, R., Tchernof, A., Diorio, C., Homer, N.Z.M., Durocher, F., Walker, B.R., Nguyen, S., Poirier, B., Denver, N., Pelletier, M., Laforest, S., Journal of Steroid Biochemistry and Molecular Biology, 2019, 10.1016/j.jsbmb.2019.105476
  • Machine learning analysis identifies genes differentiating triple negative breast cancers, Durocher, F., Diorio, C., Lambert, J.-P., Corbeil, J., Laviolette, F., Déraspe, M., Ouellette, G., Agbo, L., Osseni, M.A., Kothari, C., Scientific Reports, 2020, 10.1038/s41598-020-67525-1
  • Is Carboxypeptidase B1 a Prognostic Marker for Ductal Carcinoma In Situ?, Francine Durocher, Caroline Diorio, Annick Michaud, Kaoutar Ennour-Idrissi, Geneviève Ouellette, Alisson Clemenceau, Charu Kothari, Cancers, 2021, 10.3390/cancers13071726
  • Progesterone receptor status modifies the association between body mass index and prognosis in women diagnosed with estrogen receptor positive breast cancer, Diorio, C., Lemieux, J., Ennour-Idrissi, K., Nabi, H., Oudanonh, T., International Journal of Cancer, 2020, 10.1002/ijc.32621
  • Association between expression of inflammatory markers in normal breast tissue and mammographic density among premenopausal and postmenopausal women, Diorio, C., Poirier, B., Bureau, A., Sanschagrin, F., Têtu, B., Jacob, S., Orain, M., Dumas, I., Hanna, M., Menopause, 2017, 10.1097/GME.0000000000000794
  • Epigenome-wide DNA methylation and risk of breast cancer: a systematic review, Diorio, C., Durocher, F., Dragic, D., Ennour-Idrissi, K., BMC Cancer, 2020, 10.1186/s12885-020-07543-4
  • MCM2: An alternative to Ki-67 for measuring breast cancer cell proliferation, Gaboury, L.A., DIorio, C., Mader, S., Tahir, M.R., Laperriere, D.L., Furrer, D., Yousef, E.M., Modern Pathology, 2017, 10.1038/modpathol.2016.231
  • Concordance of HER2 immunohistochemistry and fluorescence in situ hybridization using tissue microarray in breast cancer, Diorio, C., Provencher, L., Sanschagrin, F., Caron, C., Jacob, S., Furrer, D., Anticancer Research, 2017, 10.21873/anticanres.11701
  • RE: Smoking, Sex, and Non-Small Cell Lung Cancer: Steroid Hormone Receptors in Tumor Tissue (S0424), Diorio, C., Provencher, L., Nabi, H., Journal of the National Cancer Institute, 2018, 10.1093/jnci/djy068
  • Association of Tobacco Use, Alcohol Consumption and HER2 Polymorphisms With Response to Trastuzumab in HER2-Positive Breast Cancer Patients, Diorio, C., Lemieux, J., Provencher, L., Michaud, A., Jacob, S., Furrer, D., Clinical Breast Cancer, 2018, 10.1016/j.clbc.2017.11.012
  • Association of Breast Tumour Expression of Cannabinoid Receptors CBR1 and CBR2 with Prognostic Factors and Survival in Breast Cancer Patients, Caroline Diorio, Francine Durocher, Anna Burguin, Daniela Furrer, Julie Lemieux, Éric Poirier, Kaoutar Ennour-Idrissi, Jessica Morin-Buote, Journal of Personalized Medicine, 2021, 10.3390/jpm11090852
  • Gene polymorphisms and circulating levels of MMP-2 and MMP-9: A review of their role in breast cancer risk, Diorio, C., Chang, S.-L., Dofara, S.G., Anticancer Research, 2020, 10.21873/ANTICANRES.14351
  • Association between the polymorphisms in MMP-2 and MMP-9 with adiposity and mammographic features, Caroline Diorio, Sue-Ling Chang, Suélène Georgina Dofara, Breast Cancer Research and Treatment, 2020, 10.1007/s10549-020-05651-0
  • How Wide Should Margins Be for Phyllodes Tumors of the Breast?, Desbiens, C., Diorio, C., Laberge, S., Poirier, É., Poirier, B., Provencher, L., Hogue, J.-C., Tremblay-LeMay, R., Breast Journal, 2017, 10.1111/tbj.12727
  • Role of Secreted Frizzled-Related Protein 1 in Early Mammary Gland Tumorigenesis and Its Regulation in Breast Microenvironment, Durocher, F., Diorio, C., Clemenceau, A., Cells, 2020, 10.3390/cells9010208
  • Mass spectra alignment using virtual lock-masses, Laviolette, F., Corbeil, J., Marchand, M., Diorio, C., Durocher, F., Richard, D., Gagnon, D., Drouin, A., Plante, P.-L., Brochu, F., Scientific Reports, 2019, 10.1038/s41598-019-44923-8
  • Secreted Frizzled-Related Protein 1 as a Biomarker against Incomplete Age-Related Lobular Involution and Microcalcifications’ Development, Francine Durocher, Caroline Diorio, Anna Burguin, Kaoutar Ennour-Idrissi, Mirette Hanna, Alisson Clemenceau, Cancers, 2020, 10.3390/cancers12092693
  • TBC1D9: An Important Modulator of Tumorigenesis in Breast Cancer, Francine Durocher, Caroline Diorio, René C.-Gaudreault, Annick Michaud, Kaoutar Ennour-Idrissi, Geneviève Ouellette, Alisson Clemenceau, Charu Kothari, Cancers, 2021, 10.3390/cancers13143557
  • A randomized double-blind placebo-controlled trial of the effect of Vitamin D3 supplementation on breast density in premenopausal women, Chiquette, J., Yaffe, M.J., Vieth, R., Delvin, E., Duchesne, T., Lemieux, J., Mâsse, B., Diorio, C., Bérubé, S., Brisson, J., Cancer Epidemiology Biomarkers and Prevention, 2017, 10.1158/1055-9965.EPI-17-0249
  • Identification of a gene signature for different stages of breast cancer development that could be used for early diagnosis and specific therapy, Durocher, F., Diorio, C., Jacob, S., Labrie, Y., Ouellette, G., Kothari, C., Oncotarget, 2018, 10.18632/oncotarget.26448
  • Trastuzumab effects depend on HER2 phosphorylation in HER2-negative breast cancer cell lines, Durocher, F., Diorio, C., Jacob, S., Ouellette, G., Furrer, D., Burguin, A., PLoS ONE, 2020, 10.1371/journal.pone.0234991
  • Psychosocial stressors at work and inflammatory biomarkers: PROspective Quebec Study on Work and Health, Laurin, D., Maunsell, E., Dionne, C.E., Mâsse, B., Giguère, Y., Ndjaboué, R., Diorio, C., Milot, A., Vézina, M., Trudel, X., Gilbert-Ouimet, M., Talbot, D., Brisson, C., Duchaine, C.S., Psychoneuroendocrinology, 2021, 10.1016/j.psyneuen.2021.105400
  • Association between BMI and DNA methylation in blood or normal adult breast tissue: A systematic review, Diorio, C., Durocher, F., Chang, S.-L., Michaud, A., Ennour-Idrissi, K., Dragic, D., Anticancer Research, 2020, 10.21873/anticanres.14134
  • Cumulative exposure to psychosocial stressors at work and global cognitive function: The PROspective Quebec Study on Work and Health, Laurin, D., Maunsell, E., Dionne, C.E., Mâsse, B., Giguère, Y., Ndjaboué, R., Diorio, C., Milot, A., Vézina, M., Trudel, X., Gilbert-Ouimet, M., Talbot, D., Brisson, C., Duchaine, C.S., Occupational and Environmental Medicine, 2021, 10.1136/oemed-2021-107407
  • Gene signatures of breast cancer development and the potential for novel targeted treatments, Durocher, F., Diorio, C., Kothari, C., Pharmacogenomics, 2020, 10.2217/pgs-2019-0158
  • Persistent organic pollutants and breast cancer: A systematic review and critical appraisal of the literature, Diorio, C., Ayotte, P., Ennour-Idrissi, K., Cancers, 2019, 10.3390/cancers11081063
  • Adiposity, breast density, and breast cancer risk: Epidemiological and biological considerations, Diorio, C., Tchernof, A., Durocher, F., Soguel, L., European Journal of Cancer Prevention, 2017, 10.1097/CEJ.0000000000000310
  • Prognostic and predictive value of low estrogen receptor expression in breast cancer, Diorio, C., Blanchette, C., Provencher, L., Bouchard-Fortier, A., Current Oncology, 2017, 10.3747/co.24.3238
  • Association between physical activity and the expression of mediators of inflammation in normal breast tissue among premenopausal and postmenopausal women, Diorio, C., Têtu, B., Jacob, S., Orain, M., Dumas, I., Hanna, M., Cytokine, 2018, 10.1016/j.cyto.2017.08.007
  • Mass spectra alignment using virtual lock-masses, Laviolette, F., Corbeil, J., Marchand, M., Diorio, C., Durocher, F., Richard, D., Gagnon, D., Drouin, A., Plante, P.-L., Brochu, F., bioRxiv, 2018, 10.1101/292425
  • Breast Cancer and Microcalcifications: An Osteoimmunological Disorder?, Francine Durocher, Caroline Diorio, Laetitia Michou, Alisson Clemenceau, International Journal of Molecular Sciences, 2020, 10.3390/ijms21228613
  • The importance of breast adipose tissue in breast cancer, Durocher, F., Diorio, C., Kothari, C., International Journal of Molecular Sciences, 2020, 10.3390/ijms21165760
  • A protective role of IL-37 in cancer: A new hope for cancer patients, Ahmad, A., Diorio, C., Leclerc, J.-M., Sinnett, D., Haddad, E., Duval, M., Amre, D., Samarani, S., Abulkhir, A., Journal of Leukocyte Biology, 2017, 10.1189/jlb.5RU0816-341R
  • Evaluation of Antioxidant Intakes in Relation to Inflammatory Markers Expression Within the Normal Breast Tissue of Breast Cancer Patients, Diorio, C., Têtu, B., Jacob, S., Chang, S.-L., Hanna, M., Larouche, D., Integrative Cancer Therapies, 2017, 10.1177/1534735416676584
  • An isoform of AIF1 involved in breast cancer 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis Aejaz Nasir, Durocher, F., Diorio, C., Jacob, S., Ennour-Idrissi, K., Ouellette, G., Slim, F.A., Cancer Cell International, 2018, 10.1186/s12935-018-0663-3
  • In Reply, Diorio, C., Hanna, M., Menopause, 2017, 10.1097/GME.0000000000000877
  • Associations between markers of mammary adipose tissue dysfunction and breast cancer prognostic factors, Caroline Diorio, André Tchernof, Francine Durocher, Annick Michaud, Marie-Frédérique Gauthier, Geneviève Ouellette, Kaoutar Ennour-Idrissi, Sofia Laforest, International Journal of Obesity, 2021, 10.1038/s41366-020-00676-3
  • Breast Cancer Treatments: Updates and New Challenges, Francine Durocher, Caroline Diorio, Anna Burguin, Journal of Personalized Medicine, 2021, 10.3390/jpm11080808
  • DNA Methylation and Breast Cancer Risk: An Epigenome-Wide Study of Normal Breast Tissue and Blood, Caroline Diorio, Francine Durocher, Louise Provencher, Sue-Ling Chang, Annick Michaud, Elissar Issa, Dzevka Dragic, Kaoutar Ennour-Idrissi, Cancers, 2020, 10.3390/cancers12113088
  • In response to: Long-term overall survival of patients diagnosed with pure tubular carcinoma of the breast might be affected by increased co-morbidities, Provencher, L., Hogue, J.-C., Diorio, C., Doyle, C., Lemieux, J., Jacob, S., Boudreau, D., Poirier, B., Desbiens, C., Poirier, É., Journal of Surgical Oncology, 2018, 10.1002/jso.24982
  • Breast cancer subtype and screening sensitivity in the Quebec Mammography Screening Program, Brisson, J., Pelletier, E., Lemieux, J., Diorio, C., Theberge, I., Vandal, N., Daigle, J.-M., Chang, S.-L., Perron, L., Journal of Medical Screening, 2018, 10.1177/0969141318816736

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Kaoutar Ennour-Idrissi - Doctorat - En cours
  • Juliette Bherer - Doctorat - En cours
  • Laetitia Madjri - Maîtrise avec mémoire - En cours
  • Ouafa Badre - Doctorat - En cours
  • Dzevahira Dzevka Dragic - Doctorat - En cours
  • Jacques Yonhosu Singbo Sagbohan - Maîtrise avec mémoire - En cours
  • Thibaut Nathan T Rommel - Maîtrise avec mémoire - En cours
  • Codjo Djignéfa Djade - Doctorat - En cours
  • Isabelle Dumas - Maîtrise avec mémoire - 2011/01
  • Caroline Duchaine - Maîtrise avec mémoire - 2014/05
  • Antoine Bouchard-Fortier - Maîtrise avec mémoire - 2015/05
  • Mirette Hanna - Doctorat - 2015/05
  • Ludivine Soguel Alexander - Maîtrise avec mémoire - 2015/09
  • Sofia Laforest - Maîtrise avec mémoire - 2016/05
  • Daniela Furrer Soliz Urrutia - Maîtrise avec mémoire - 2016/09
  • Danielle Larouche - Maîtrise avec mémoire - 2017/01
  • Elissar Issa - Maîtrise avec mémoire - 2018/01
  • Ferial Amira Slim - Maîtrise avec mémoire - 2018/05
  • Vanina Sandy Tchuente Nguedem - Maîtrise avec mémoire - 2018/09
  • Charu Kothari - Doctorat - 2021/01
  • Jessica Morin-Buote - Maîtrise avec mémoire - 2021/05
  • Alisson Clemenceau - Doctorat - 2022/05
  • Mamady Magassouba - Maîtrise avec mémoire - 2022/05
  • Anna Burguin - Doctorat - 2022/09

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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