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Caroline Diorio

Professeure titulaire

Centre de recherche sur le cancer
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Bioinformatique / données massives (big data)
Médecine régénératrice et moléculaire
Oncologie
Santé des populations et pratiques optimales en santé

Domaines et intérêts de recherche du (de la) professeur(e) :

Cancer
  • Cancer du sein
  • Nutrition et cancer
  • Diagnostic et détection du cancer
  • Cancers hormonaux-dépendants
  • Environnement et cancer
  • Carcinogénèse
  • Stress et cancer
  • Déterminants sociaux du cancer
Génétique humaine
  • Interactions gènes et environnement
  • Télomères
  • Micropuces d'ADN et d'ARN
  • Polymorphisme
  • Génomique
Nutrition et métabolisme
  • Obésité
  • Nutrition
  • Nutriments
  • Hormones et facteurs de croissance
  • Métabolisme des médicaments
Santé des populations
  • Habitudes de vie et santé
  • Pharmaco-épidémiologie
  • Prévention en santé
  • Santé environnementale

Projets de recherche

  • Management of sleeve gastrectomy failure using single-anastomosis metabolic surgery - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2021-10-01 au 2026-09-30
  • Omega-3 fatty acids in the prevention of breast cancer: role of obesity-related markers in breast tissues - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2018-10-01 au 2026-09-30
  • L’AIMZ-938, un nouveau promédicament anticancéreux pour le traitement des cancers du sein humain réfractaires aux traitements actuels et exprimant le cytochrome P450 1A1 - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2021-10-01 au 2026-09-30
  • Salaire d'un professeur - CHU de Québec – Université Laval – Hôpital l'Enfant-Jésus, chercheur principal - 2010-07-01 au 2025-06-30
  • Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
  • Effect of environmental contaminants and methylome of breast adipose tissue on aromatase inhibitor efficacy in breast cancer - Instituts de recherche en santé du Canada - Volet Projet: Concours pilotes, chercheur principal - 2016-07-01 au 2024-09-30
  • Deciphering the role of FGD5 during breast cancer progression - Fondation de l'Université Laval, co-chercheur - 2021-05-01 au 2023-04-30
  • Breast adipocyte hypertrophy: a novel biomarker to predict breast cancer survival - American Institute for Cancer Research - Subvention de fonctionnement, chercheur principal - 2022-01-01 au 2023-03-31
  • What are my options? A feasibility study of a personalized primary prevention strategy for women and men at high risk of breast and prostate cancer - Instituts de recherche en santé du Canada, Fondation du cancer du sein du Québec, Société canadienne du cancer - Initiative SCC/IC-IRSC en prévention primaire du cancer, co-chercheur - 2022-01-15 au 2023-01-14
  • Utilisation de l'intelligence artificielle (IA) afin de prédire les résultats de biopsies faites pour les mammographies anormales avec comme but ultime de réduire le nombre de biopsies - Fonds de recherche du Québec - Santé, Imagia, Ministère de l'Économie et de l'Innovation, co-chercheur - 2019-12-09 au 2021-12-08
  • Bourse Concert pour la vie - Fondation du CHU de Québec, co-chercheur - 2020-11-13 au 2021-11-12
  • Banque de tissu Sein-Ovaire - Fonds de recherche du Québec - Santé - Réseaux thématiques de recherche, chercheur principal - 2000-01-01 au 2021-09-30
  • Deciphering breast cancer HER2-negativity with regard to HER2-targeted therapy - Instituts de recherche en santé du Canada - Volet Projet: Concours pilotes, co-chercheur - 2016-07-01 au 2021-06-30
  • Design for Better Health: User-Centred Design and Evaluation of Interactive Media for Health Education, Communication and Decision-Making - Instituts de recherche en santé du Canada - Subventions Fondation, co-chercheur - 2016-07-01 au 2021-06-30
  • Axe banque de tissus et de données BTD - Fondation du cancer du sein du Québec, chercheur principal - 2011-04-01 au 2021-03-31
  • Une approche personnalisée pour la prévention et le traitement du cancer du sein - Fonds de recherche du Québec - Santé - Chercheur-boursier Juniors 1 et 2, Seniors, chercheur principal - 2017-08-01 au 2020-07-31

Publications

  • Association of Breast Tumour Expression of Cannabinoid Receptors CBR1 and CBR2 with Prognostic Factors and Survival in Breast Cancer Patients, Jessica Morin-Buote, Kaoutar Ennour-Idrissi, Éric Poirier, Julie Lemieux, Daniela Furrer, Anna Burguin, Francine Durocher, Caroline Diorio, Journal of Personalized Medicine, 2021, 10.3390/jpm11090852
  • Identifying Clinicopathological Factors Associated with Oncotype DX® 21-Gene Recurrence Score: A Real-World Retrospective Cohort Study of Breast Cancer Patients in Quebec City, Canada, Simon Gagnet, Caroline Diorio, Louise Provencher, Cynthia Mbuya-Bienge, Julie Lapointe, Claudya Morin, Julie Lemieux, Hermann Nabi, Journal of Personalized Medicine, 2021, 10.3390/jpm11090858
  • Breast Cancer Treatments: Updates and New Challenges, Anna Burguin, Caroline Diorio, Francine Durocher, Journal of Personalized Medicine, 2021, 10.3390/jpm11080808
  • Associations of Biomarkers of Inflammation and Breast Cancer in the Breast Adipose Tissue of Women with Combined Measures of Adiposity, Sue-Ling Chang, André Tchernof, Francine Durocher, Caroline Diorio, Journal of Obesity, 2021, 10.1155/2021/3620147
  • TBC1D9: An Important Modulator of Tumorigenesis in Breast Cancer, Charu Kothari, Alisson Clemenceau, Geneviève Ouellette, Kaoutar Ennour-Idrissi, Annick Michaud, René C.-Gaudreault, Caroline Diorio, Francine Durocher, Cancers, 2021, 10.3390/cancers13143557
  • Is Carboxypeptidase B1 a Prognostic Marker for Ductal Carcinoma In Situ?, Charu Kothari, Alisson Clemenceau, Geneviève Ouellette, Kaoutar Ennour-Idrissi, Annick Michaud, Caroline Diorio, Francine Durocher, Cancers, 2021, 10.3390/cancers13071726
  • Associations between markers of mammary adipose tissue dysfunction and breast cancer prognostic factors, Sofia Laforest, Kaoutar Ennour-Idrissi, Geneviève Ouellette, Marie-Frédérique Gauthier, Annick Michaud, Francine Durocher, André Tchernof, Caroline Diorio, International Journal of Obesity, 2021, 10.1038/s41366-020-00676-3
  • Cumulative exposure to psychosocial stressors at work and global cognitive function: The PROspective Quebec Study on Work and Health, Duchaine, C.S., Brisson, C., Talbot, D., Gilbert-Ouimet, M., Trudel, X., Vézina, M., Milot, A., Diorio, C., Ndjaboué, R., Giguère, Y., Mâsse, B., Dionne, C.E., Maunsell, E., Laurin, D., Occupational and Environmental Medicine, 2021, 10.1136/oemed-2021-107407
  • Psychosocial stressors at work and inflammatory biomarkers: PROspective Quebec Study on Work and Health, Duchaine, C.S., Brisson, C., Talbot, D., Gilbert-Ouimet, M., Trudel, X., Vézina, M., Milot, A., Diorio, C., Ndjaboué, R., Giguère, Y., Mâsse, B., Dionne, C.E., Maunsell, E., Laurin, D., Psychoneuroendocrinology, 2021, 10.1016/j.psyneuen.2021.105400
  • Breast Cancer and Microcalcifications: An Osteoimmunological Disorder?, Alisson Clemenceau, Laetitia Michou, Caroline Diorio, Francine Durocher, International Journal of Molecular Sciences, 2020, 10.3390/ijms21228613
  • DNA Methylation and Breast Cancer Risk: An Epigenome-Wide Study of Normal Breast Tissue and Blood, Kaoutar Ennour-Idrissi, Dzevka Dragic, Elissar Issa, Annick Michaud, Sue-Ling Chang, Louise Provencher, Francine Durocher, Caroline Diorio, Cancers, 2020, 10.3390/cancers12113088
  • Secreted Frizzled-Related Protein 1 as a Biomarker against Incomplete Age-Related Lobular Involution and Microcalcifications’ Development, Alisson Clemenceau, Mirette Hanna, Kaoutar Ennour-Idrissi, Anna Burguin, Caroline Diorio, Francine Durocher, Cancers, 2020, 10.3390/cancers12092693
  • Association between the polymorphisms in MMP-2 and MMP-9 with adiposity and mammographic features, Suélène Georgina Dofara, Sue-Ling Chang, Caroline Diorio, Breast Cancer Research and Treatment, 2020, 10.1007/s10549-020-05651-0
  • Association between BMI and DNA methylation in blood or normal adult breast tissue: A systematic review, Dragic, D., Ennour-Idrissi, K., Michaud, A., Chang, S.-L., Durocher, F., Diorio, C., Anticancer Research, 2020, 10.21873/anticanres.14134
  • Epigenome-wide DNA methylation and risk of breast cancer: a systematic review, Ennour-Idrissi, K., Dragic, D., Durocher, F., Diorio, C., BMC Cancer, 2020, 10.1186/s12885-020-07543-4
  • Estrogens and glucocorticoids in mammary adipose tissue: Relationships with body mass index and breast cancer features, Laforest, S., Pelletier, M., Denver, N., Poirier, B., Nguyen, S., Walker, B.R., Durocher, F., Homer, N.Z.M., Diorio, C., Andrew, R., Tchernof, A., Journal of Clinical Endocrinology and Metabolism, 2020, 10.1210/clinem/dgz268
  • Gene polymorphisms and circulating levels of MMP-2 and MMP-9: A review of their role in breast cancer risk, Dofara, S.G., Chang, S.-L., Diorio, C., Anticancer Research, 2020, 10.21873/ANTICANRES.14351
  • Gene signatures of breast cancer development and the potential for novel targeted treatments, Kothari, C., Diorio, C., Durocher, F., Pharmacogenomics, 2020, 10.2217/pgs-2019-0158
  • Machine learning analysis identifies genes differentiating triple negative breast cancers, Kothari, C., Osseni, M.A., Agbo, L., Ouellette, G., Déraspe, M., Laviolette, F., Corbeil, J., Lambert, J.-P., Diorio, C., Durocher, F., Scientific Reports, 2020, 10.1038/s41598-020-67525-1
  • Progesterone receptor status modifies the association between body mass index and prognosis in women diagnosed with estrogen receptor positive breast cancer, Oudanonh, T., Nabi, H., Ennour-Idrissi, K., Lemieux, J., Diorio, C., International Journal of Cancer, 2020, 10.1002/ijc.32621
  • Role of Secreted Frizzled-Related Protein 1 in Early Mammary Gland Tumorigenesis and Its Regulation in Breast Microenvironment, Clemenceau, A., Diorio, C., Durocher, F., Cells, 2020, 10.3390/cells9010208
  • The importance of breast adipose tissue in breast cancer, Kothari, C., Diorio, C., Durocher, F., International Journal of Molecular Sciences, 2020, 10.3390/ijms21165760
  • Trastuzumab effects depend on HER2 phosphorylation in HER2-negative breast cancer cell lines, Burguin, A., Furrer, D., Ouellette, G., Jacob, S., Diorio, C., Durocher, F., PLoS ONE, 2020, 10.1371/journal.pone.0234991
  • Dairy food consumption and mammographic breast density: The role of fat, Canitrot, E., Diorio, C., Anticancer Research, 2019, 10.21873/anticanres.13828
  • Mass spectra alignment using virtual lock-masses, Brochu, F., Plante, P.-L., Drouin, A., Gagnon, D., Richard, D., Durocher, F., Diorio, C., Marchand, M., Corbeil, J., Laviolette, F., Scientific Reports, 2019, 10.1038/s41598-019-44923-8
  • Omega-3 fatty acids survey in men under active surveillance for prostate cancer: from intake to prostate tissue level, Moussa, H., Nguile-Makao, M., Robitaille, K., Guertin, M., Allaire, J., Pelletier, J., Moreel, X., Gevariya, N., Diorio, C., Desmeules, P., Têtu, B., Lamarche, B., Julien, P., Fradet, V., Nutrients, 2019, 10.3390/nu11071616
  • Persistent organic pollutants and breast cancer: A systematic review and critical appraisal of the literature, Ennour-Idrissi, K., Ayotte, P., Diorio, C., Cancers, 2019, 10.3390/cancers11081063
  • Simultaneous quantification of estrogens and glucocorticoids in human adipose tissue by liquid-chromatography-tandem mass spectrometry, Laforest, S., Pelletier, M., Denver, N., Poirier, B., Nguyen, S., Walker, B.R., Durocher, F., Homer, N.Z.M., Diorio, C., Tchernof, A., Andrew, R., Journal of Steroid Biochemistry and Molecular Biology, 2019, 10.1016/j.jsbmb.2019.105476
  • An isoform of AIF1 involved in breast cancer 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis Aejaz Nasir, Slim, F.A., Ouellette, G., Ennour-Idrissi, K., Jacob, S., Diorio, C., Durocher, F., Cancer Cell International, 2018, 10.1186/s12935-018-0663-3
  • Association between physical activity and the expression of mediators of inflammation in normal breast tissue among premenopausal and postmenopausal women, Hanna, M., Dumas, I., Orain, M., Jacob, S., Têtu, B., Diorio, C., Cytokine, 2018, 10.1016/j.cyto.2017.08.007
  • Association of Tobacco Use, Alcohol Consumption and HER2 Polymorphisms With Response to Trastuzumab in HER2-Positive Breast Cancer Patients, Furrer, D., Jacob, S., Michaud, A., Provencher, L., Lemieux, J., Diorio, C., Clinical Breast Cancer, 2018, 10.1016/j.clbc.2017.11.012
  • Body mass index and clinical outcomes in trastuzumab-treated metastatic breast cancer patients: An alternative explanation for the lack of association, Nabi, H., Diorio, C., Breast, 2018, 10.1016/j.breast.2018.02.030
  • Body-mass index and metastatic melanoma outcomes, Nabi, H., Guertin, J.R., Talbot, D., Diorio, C., The Lancet Oncology, 2018, 10.1016/S1470-2045(18)30287-0
  • Breast cancer subtype and screening sensitivity in the Quebec Mammography Screening Program, Perron, L., Chang, S.-L., Daigle, J.-M., Vandal, N., Theberge, I., Diorio, C., Lemieux, J., Pelletier, E., Brisson, J., Journal of Medical Screening, 2018, 10.1177/0969141318816736
  • Characteristics and long-term survival of patients diagnosed with pure tubular carcinoma of the breast, Poirier, É., Desbiens, C., Poirier, B., Boudreau, D., Jacob, S., Lemieux, J., Doyle, C., Diorio, C., Hogue, J.-C., Provencher, L., Journal of Surgical Oncology, 2018, 10.1002/jso.24944
  • Identification of a gene signature for different stages of breast cancer development that could be used for early diagnosis and specific therapy, Kothari, C., Ouellette, G., Labrie, Y., Jacob, S., Diorio, C., Durocher, F., Oncotarget, 2018, 10.18632/oncotarget.26448
  • In response to: Long-term overall survival of patients diagnosed with pure tubular carcinoma of the breast might be affected by increased co-morbidities, Poirier, É., Desbiens, C., Poirier, B., Boudreau, D., Jacob, S., Lemieux, J., Doyle, C., Diorio, C., Hogue, J.-C., Provencher, L., Journal of Surgical Oncology, 2018, 10.1002/jso.24982
  • Mass spectra alignment using virtual lock-masses, Brochu, F., Plante, P.-L., Drouin, A., Gagnon, D., Richard, D., Durocher, F., Diorio, C., Marchand, M., Corbeil, J., Laviolette, F., bioRxiv, 2018, 10.1101/292425
  • RE: Smoking, Sex, and Non-Small Cell Lung Cancer: Steroid Hormone Receptors in Tumor Tissue (S0424), Nabi, H., Provencher, L., Diorio, C., Journal of the National Cancer Institute, 2018, 10.1093/jnci/djy068
  • A protective role of IL-37 in cancer: A new hope for cancer patients, Abulkhir, A., Samarani, S., Amre, D., Duval, M., Haddad, E., Sinnett, D., Leclerc, J.-M., Diorio, C., Ahmad, A., Journal of Leukocyte Biology, 2017, 10.1189/jlb.5RU0816-341R
  • A randomized double-blind placebo-controlled trial of the effect of Vitamin D3 supplementation on breast density in premenopausal women, Brisson, J., Bérubé, S., Diorio, C., Mâsse, B., Lemieux, J., Duchesne, T., Delvin, E., Vieth, R., Yaffe, M.J., Chiquette, J., Cancer Epidemiology Biomarkers and Prevention, 2017, 10.1158/1055-9965.EPI-17-0249
  • Adiposity, breast density, and breast cancer risk: Epidemiological and biological considerations, Soguel, L., Durocher, F., Tchernof, A., Diorio, C., European Journal of Cancer Prevention, 2017, 10.1097/CEJ.0000000000000310
  • Association between expression of inflammatory markers in normal breast tissue and mammographic density among premenopausal and postmenopausal women, Hanna, M., Dumas, I., Orain, M., Jacob, S., Têtu, B., Sanschagrin, F., Bureau, A., Poirier, B., Diorio, C., Menopause, 2017, 10.1097/GME.0000000000000794
  • Association between local inflammation and breast tissue age-related lobular involution among premenopausal and postmenopausal breast cancer patients, Hanna, M., Dumas, I., Orain, M., Jacob, S., Têtu, B., Sanschagrin, F., Bureau, A., Poirier, B., Diorio, C., PLoS ONE, 2017, 10.1371/journal.pone.0183579
  • Concordance of HER2 immunohistochemistry and fluorescence in situ hybridization using tissue microarray in breast cancer, Furrer, D., Jacob, S., Caron, C., Sanschagrin, F., Provencher, L., Diorio, C., Anticancer Research, 2017, 10.21873/anticanres.11701
  • Evaluation of Antioxidant Intakes in Relation to Inflammatory Markers Expression Within the Normal Breast Tissue of Breast Cancer Patients, Larouche, D., Hanna, M., Chang, S.-L., Jacob, S., Têtu, B., Diorio, C., Integrative Cancer Therapies, 2017, 10.1177/1534735416676584
  • How Wide Should Margins Be for Phyllodes Tumors of the Breast?, Tremblay-LeMay, R., Hogue, J.-C., Provencher, L., Poirier, B., Poirier, É., Laberge, S., Diorio, C., Desbiens, C., Breast Journal, 2017, 10.1111/tbj.12727
  • In Reply, Hanna, M., Diorio, C., Menopause, 2017, 10.1097/GME.0000000000000877
  • MCM2: An alternative to Ki-67 for measuring breast cancer cell proliferation, Yousef, E.M., Furrer, D., Laperriere, D.L., Tahir, M.R., Mader, S., DIorio, C., Gaboury, L.A., Modern Pathology, 2017, 10.1038/modpathol.2016.231
  • Prognostic and predictive value of low estrogen receptor expression in breast cancer, Bouchard-Fortier, A., Provencher, L., Blanchette, C., Diorio, C., Current Oncology, 2017, 10.3747/co.24.3238

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Anna Burguin - Doctorat - En cours
  • Elissar Issa - Doctorat - En cours
  • Annie Bourassa - Maitrîse avec mémoire - En cours
  • Juliette Bherer - Maitrîse avec mémoire - En cours
  • Kaoutar Ennour-Idrissi - Doctorat - En cours
  • Codjo Djignéfa Djade - Doctorat - En cours
  • Laetitia Madjri - Maitrîse avec mémoire - En cours
  • Farida Hamidou Farida Hamidou - Maitrîse avec mémoire - En cours
  • Dzevahira Dzevka Dragic - Doctorat - En cours
  • Alisson Clemenceau - Doctorat - En cours
  • Isabelle Dumas - Maitrîse avec mémoire - 2011/01
  • Caroline Duchaine - Maitrîse avec mémoire - 2014/05
  • Antoine Bouchard-Fortier - Maitrîse avec mémoire - 2015/05
  • Mirette Hanna - Doctorat - 2015/05
  • Ludivine Soguel Alexander - Maitrîse avec mémoire - 2015/09
  • Sofia Laforest - Maitrîse avec mémoire - 2016/05
  • Daniela Furrer Soliz Urrutia - Maitrîse avec mémoire - 2016/09
  • Danielle Larouche - Maitrîse avec mémoire - 2017/01
  • Ferial Amira Slim - Maitrîse avec mémoire - 2018/05
  • Vanina Sandy Tchuente Nguedem - Maitrîse avec mémoire - 2018/09
  • Charu Kothari - Doctorat - 2021/01
  • Jessica Morin-Buote - Maitrîse avec mémoire - 2021/05
  • Mamady Magassouba - Maitrîse avec mémoire - 2022/05

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.

Direction et personnes-ressources

Vice-décanat à la recherche et aux études supérieures
Pavillon Ferdinand-Vandry
Université Laval
1050, avenue de la Médecine, local 4645
Québec (Québec) G1V 0A6
Canada

Renseignements - Secrétariat
418 656-2690
vdres@fmed.ulaval.ca

Jacques Simard
Vice-doyen à la recherche et aux études supérieures
vice-doyen.recherche-et-etudes-superieures@fmed.ulaval.ca

Louise Laperrière
Adjointe au vice-doyen à la recherche et aux études supérieures
louise.laperriere@fmed.ulaval.ca 

Volet recherche
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