Caroline Diorio

Professeure titulaire

caroline.diorio@fmed.ulaval.ca

Département de médecine sociale et préventive

Centre de recherche sur le cancer

Centre de recherche du CHU de Québec - Université Laval

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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Bioinformatique / données massives (big data)

Médecine régénératrice et moléculaire

Oncologie

Santé des populations et pratiques optimales en santé

Domaines et intérêts de recherche du (de la) professeur(e) :

Cancer

Cancer du sein
Nutrition et cancer
Diagnostic et détection du cancer
Cancers hormonaux-dépendants
Environnement et cancer
Carcinogénèse
Stress et cancer
Déterminants sociaux du cancer

Génétique humaine

Interactions gènes et environnement
Télomères
Micropuces d'ADN et d'ARN
Polymorphisme
Génomique

Nutrition et métabolisme

Obésité
Nutrition
Nutriments
Hormones et facteurs de croissance
Métabolisme des médicaments

Santé des populations

Habitudes de vie et santé
Pharmaco-épidémiologie
Prévention en santé
Santé environnementale

Projets de recherche

Management of sleeve gastrectomy failure using single-anastomosis metabolic surgery - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2021-10-01 au 2026-09-30
Omega-3 fatty acids in the prevention of breast cancer: role of obesity-related markers in breast tissues - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2018-10-01 au 2026-09-30
L’AIMZ-938, un nouveau promédicament anticancéreux pour le traitement des cancers du sein humain réfractaires aux traitements actuels et exprimant le cytochrome P450 1A1 - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2021-10-01 au 2026-09-30
Salaire d'un professeur - CHU de Québec – Université Laval – Hôpital l'Enfant-Jésus, chercheur principal - 2010-07-01 au 2025-06-30
Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
Effect of environmental contaminants and methylome of breast adipose tissue on aromatase inhibitor efficacy in breast cancer - Instituts de recherche en santé du Canada - Volet Projet: Concours pilotes, chercheur principal - 2016-07-01 au 2024-09-30
Deciphering the role of FGD5 during breast cancer progression - Fondation de l'Université Laval, co-chercheur - 2021-05-01 au 2023-04-30
Breast adipocyte hypertrophy: a novel biomarker to predict breast cancer survival - American Institute for Cancer Research - Subvention de fonctionnement, chercheur principal - 2022-01-01 au 2023-03-31
What are my options? A feasibility study of a personalized primary prevention strategy for women and men at high risk of breast and prostate cancer - Instituts de recherche en santé du Canada, Fondation du cancer du sein du Québec, Société canadienne du cancer - Initiative SCC/IC-IRSC en prévention primaire du cancer, co-chercheur - 2022-01-15 au 2023-01-14
Utilisation de l'intelligence artificielle (IA) afin de prédire les résultats de biopsies faites pour les mammographies anormales avec comme but ultime de réduire le nombre de biopsies - Fonds de recherche du Québec - Santé, Imagia, Ministère de l'Économie et de l'Innovation, co-chercheur - 2019-12-09 au 2021-12-08
Bourse Concert pour la vie - Fondation du CHU de Québec, co-chercheur - 2020-11-13 au 2021-11-12
Banque de tissu Sein-Ovaire - Fonds de recherche du Québec - Santé - Réseaux thématiques de recherche, chercheur principal - 2000-01-01 au 2021-09-30
Deciphering breast cancer HER2-negativity with regard to HER2-targeted therapy - Instituts de recherche en santé du Canada - Volet Projet: Concours pilotes, co-chercheur - 2016-07-01 au 2021-06-30
Design for Better Health: User-Centred Design and Evaluation of Interactive Media for Health Education, Communication and Decision-Making - Instituts de recherche en santé du Canada - Subventions Fondation, co-chercheur - 2016-07-01 au 2021-06-30
Axe banque de tissus et de données BTD - Fondation du cancer du sein du Québec, chercheur principal - 2011-04-01 au 2021-03-31
Une approche personnalisée pour la prévention et le traitement du cancer du sein - Fonds de recherche du Québec - Santé - Chercheur-boursier Juniors 1 et 2, Seniors, chercheur principal - 2017-08-01 au 2020-07-31

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Publications

Association of Breast Tumour Expression of Cannabinoid Receptors CBR1 and CBR2 with Prognostic Factors and Survival in Breast Cancer Patients, Jessica Morin-Buote, Kaoutar Ennour-Idrissi, Éric Poirier, Julie Lemieux, Daniela Furrer, Anna Burguin, Francine Durocher, Caroline Diorio, Journal of Personalized Medicine, 2021, 10.3390/jpm11090852
Identifying Clinicopathological Factors Associated with Oncotype DX® 21-Gene Recurrence Score: A Real-World Retrospective Cohort Study of Breast Cancer Patients in Quebec City, Canada, Simon Gagnet, Caroline Diorio, Louise Provencher, Cynthia Mbuya-Bienge, Julie Lapointe, Claudya Morin, Julie Lemieux, Hermann Nabi, Journal of Personalized Medicine, 2021, 10.3390/jpm11090858
Breast Cancer Treatments: Updates and New Challenges, Anna Burguin, Caroline Diorio, Francine Durocher, Journal of Personalized Medicine, 2021, 10.3390/jpm11080808
Associations of Biomarkers of Inflammation and Breast Cancer in the Breast Adipose Tissue of Women with Combined Measures of Adiposity, Sue-Ling Chang, André Tchernof, Francine Durocher, Caroline Diorio, Journal of Obesity, 2021, 10.1155/2021/3620147
TBC1D9: An Important Modulator of Tumorigenesis in Breast Cancer, Charu Kothari, Alisson Clemenceau, Geneviève Ouellette, Kaoutar Ennour-Idrissi, Annick Michaud, René C.-Gaudreault, Caroline Diorio, Francine Durocher, Cancers, 2021, 10.3390/cancers13143557
Is Carboxypeptidase B1 a Prognostic Marker for Ductal Carcinoma In Situ?, Charu Kothari, Alisson Clemenceau, Geneviève Ouellette, Kaoutar Ennour-Idrissi, Annick Michaud, Caroline Diorio, Francine Durocher, Cancers, 2021, 10.3390/cancers13071726
Associations between markers of mammary adipose tissue dysfunction and breast cancer prognostic factors, Sofia Laforest, Kaoutar Ennour-Idrissi, Geneviève Ouellette, Marie-Frédérique Gauthier, Annick Michaud, Francine Durocher, André Tchernof, Caroline Diorio, International Journal of Obesity, 2021, 10.1038/s41366-020-00676-3
Cumulative exposure to psychosocial stressors at work and global cognitive function: The PROspective Quebec Study on Work and Health, Duchaine, C.S., Brisson, C., Talbot, D., Gilbert-Ouimet, M., Trudel, X., Vézina, M., Milot, A., Diorio, C., Ndjaboué, R., Giguère, Y., Mâsse, B., Dionne, C.E., Maunsell, E., Laurin, D., Occupational and Environmental Medicine, 2021, 10.1136/oemed-2021-107407
Psychosocial stressors at work and inflammatory biomarkers: PROspective Quebec Study on Work and Health, Duchaine, C.S., Brisson, C., Talbot, D., Gilbert-Ouimet, M., Trudel, X., Vézina, M., Milot, A., Diorio, C., Ndjaboué, R., Giguère, Y., Mâsse, B., Dionne, C.E., Maunsell, E., Laurin, D., Psychoneuroendocrinology, 2021, 10.1016/j.psyneuen.2021.105400
Breast Cancer and Microcalcifications: An Osteoimmunological Disorder?, Alisson Clemenceau, Laetitia Michou, Caroline Diorio, Francine Durocher, International Journal of Molecular Sciences, 2020, 10.3390/ijms21228613
DNA Methylation and Breast Cancer Risk: An Epigenome-Wide Study of Normal Breast Tissue and Blood, Kaoutar Ennour-Idrissi, Dzevka Dragic, Elissar Issa, Annick Michaud, Sue-Ling Chang, Louise Provencher, Francine Durocher, Caroline Diorio, Cancers, 2020, 10.3390/cancers12113088
Secreted Frizzled-Related Protein 1 as a Biomarker against Incomplete Age-Related Lobular Involution and Microcalcifications’ Development, Alisson Clemenceau, Mirette Hanna, Kaoutar Ennour-Idrissi, Anna Burguin, Caroline Diorio, Francine Durocher, Cancers, 2020, 10.3390/cancers12092693
Association between the polymorphisms in MMP-2 and MMP-9 with adiposity and mammographic features, Suélène Georgina Dofara, Sue-Ling Chang, Caroline Diorio, Breast Cancer Research and Treatment, 2020, 10.1007/s10549-020-05651-0
Association between BMI and DNA methylation in blood or normal adult breast tissue: A systematic review, Dragic, D., Ennour-Idrissi, K., Michaud, A., Chang, S.-L., Durocher, F., Diorio, C., Anticancer Research, 2020, 10.21873/anticanres.14134
Epigenome-wide DNA methylation and risk of breast cancer: a systematic review, Ennour-Idrissi, K., Dragic, D., Durocher, F., Diorio, C., BMC Cancer, 2020, 10.1186/s12885-020-07543-4
Estrogens and glucocorticoids in mammary adipose tissue: Relationships with body mass index and breast cancer features, Laforest, S., Pelletier, M., Denver, N., Poirier, B., Nguyen, S., Walker, B.R., Durocher, F., Homer, N.Z.M., Diorio, C., Andrew, R., Tchernof, A., Journal of Clinical Endocrinology and Metabolism, 2020, 10.1210/clinem/dgz268
Gene polymorphisms and circulating levels of MMP-2 and MMP-9: A review of their role in breast cancer risk, Dofara, S.G., Chang, S.-L., Diorio, C., Anticancer Research, 2020, 10.21873/ANTICANRES.14351
Gene signatures of breast cancer development and the potential for novel targeted treatments, Kothari, C., Diorio, C., Durocher, F., Pharmacogenomics, 2020, 10.2217/pgs-2019-0158
Machine learning analysis identifies genes differentiating triple negative breast cancers, Kothari, C., Osseni, M.A., Agbo, L., Ouellette, G., Déraspe, M., Laviolette, F., Corbeil, J., Lambert, J.-P., Diorio, C., Durocher, F., Scientific Reports, 2020, 10.1038/s41598-020-67525-1
Progesterone receptor status modifies the association between body mass index and prognosis in women diagnosed with estrogen receptor positive breast cancer, Oudanonh, T., Nabi, H., Ennour-Idrissi, K., Lemieux, J., Diorio, C., International Journal of Cancer, 2020, 10.1002/ijc.32621
Role of Secreted Frizzled-Related Protein 1 in Early Mammary Gland Tumorigenesis and Its Regulation in Breast Microenvironment, Clemenceau, A., Diorio, C., Durocher, F., Cells, 2020, 10.3390/cells9010208
The importance of breast adipose tissue in breast cancer, Kothari, C., Diorio, C., Durocher, F., International Journal of Molecular Sciences, 2020, 10.3390/ijms21165760
Trastuzumab effects depend on HER2 phosphorylation in HER2-negative breast cancer cell lines, Burguin, A., Furrer, D., Ouellette, G., Jacob, S., Diorio, C., Durocher, F., PLoS ONE, 2020, 10.1371/journal.pone.0234991
Dairy food consumption and mammographic breast density: The role of fat, Canitrot, E., Diorio, C., Anticancer Research, 2019, 10.21873/anticanres.13828
Mass spectra alignment using virtual lock-masses, Brochu, F., Plante, P.-L., Drouin, A., Gagnon, D., Richard, D., Durocher, F., Diorio, C., Marchand, M., Corbeil, J., Laviolette, F., Scientific Reports, 2019, 10.1038/s41598-019-44923-8
Omega-3 fatty acids survey in men under active surveillance for prostate cancer: from intake to prostate tissue level, Moussa, H., Nguile-Makao, M., Robitaille, K., Guertin, M., Allaire, J., Pelletier, J., Moreel, X., Gevariya, N., Diorio, C., Desmeules, P., Têtu, B., Lamarche, B., Julien, P., Fradet, V., Nutrients, 2019, 10.3390/nu11071616
Persistent organic pollutants and breast cancer: A systematic review and critical appraisal of the literature, Ennour-Idrissi, K., Ayotte, P., Diorio, C., Cancers, 2019, 10.3390/cancers11081063
Simultaneous quantification of estrogens and glucocorticoids in human adipose tissue by liquid-chromatography-tandem mass spectrometry, Laforest, S., Pelletier, M., Denver, N., Poirier, B., Nguyen, S., Walker, B.R., Durocher, F., Homer, N.Z.M., Diorio, C., Tchernof, A., Andrew, R., Journal of Steroid Biochemistry and Molecular Biology, 2019, 10.1016/j.jsbmb.2019.105476
An isoform of AIF1 involved in breast cancer 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis Aejaz Nasir, Slim, F.A., Ouellette, G., Ennour-Idrissi, K., Jacob, S., Diorio, C., Durocher, F., Cancer Cell International, 2018, 10.1186/s12935-018-0663-3
Association between physical activity and the expression of mediators of inflammation in normal breast tissue among premenopausal and postmenopausal women, Hanna, M., Dumas, I., Orain, M., Jacob, S., Têtu, B., Diorio, C., Cytokine, 2018, 10.1016/j.cyto.2017.08.007
Association of Tobacco Use, Alcohol Consumption and HER2 Polymorphisms With Response to Trastuzumab in HER2-Positive Breast Cancer Patients, Furrer, D., Jacob, S., Michaud, A., Provencher, L., Lemieux, J., Diorio, C., Clinical Breast Cancer, 2018, 10.1016/j.clbc.2017.11.012
Body mass index and clinical outcomes in trastuzumab-treated metastatic breast cancer patients: An alternative explanation for the lack of association, Nabi, H., Diorio, C., Breast, 2018, 10.1016/j.breast.2018.02.030
Body-mass index and metastatic melanoma outcomes, Nabi, H., Guertin, J.R., Talbot, D., Diorio, C., The Lancet Oncology, 2018, 10.1016/S1470-2045(18)30287-0
Breast cancer subtype and screening sensitivity in the Quebec Mammography Screening Program, Perron, L., Chang, S.-L., Daigle, J.-M., Vandal, N., Theberge, I., Diorio, C., Lemieux, J., Pelletier, E., Brisson, J., Journal of Medical Screening, 2018, 10.1177/0969141318816736
Characteristics and long-term survival of patients diagnosed with pure tubular carcinoma of the breast, Poirier, É., Desbiens, C., Poirier, B., Boudreau, D., Jacob, S., Lemieux, J., Doyle, C., Diorio, C., Hogue, J.-C., Provencher, L., Journal of Surgical Oncology, 2018, 10.1002/jso.24944
Identification of a gene signature for different stages of breast cancer development that could be used for early diagnosis and specific therapy, Kothari, C., Ouellette, G., Labrie, Y., Jacob, S., Diorio, C., Durocher, F., Oncotarget, 2018, 10.18632/oncotarget.26448
In response to: Long-term overall survival of patients diagnosed with pure tubular carcinoma of the breast might be affected by increased co-morbidities, Poirier, É., Desbiens, C., Poirier, B., Boudreau, D., Jacob, S., Lemieux, J., Doyle, C., Diorio, C., Hogue, J.-C., Provencher, L., Journal of Surgical Oncology, 2018, 10.1002/jso.24982
Mass spectra alignment using virtual lock-masses, Brochu, F., Plante, P.-L., Drouin, A., Gagnon, D., Richard, D., Durocher, F., Diorio, C., Marchand, M., Corbeil, J., Laviolette, F., bioRxiv, 2018, 10.1101/292425
RE: Smoking, Sex, and Non-Small Cell Lung Cancer: Steroid Hormone Receptors in Tumor Tissue (S0424), Nabi, H., Provencher, L., Diorio, C., Journal of the National Cancer Institute, 2018, 10.1093/jnci/djy068
A protective role of IL-37 in cancer: A new hope for cancer patients, Abulkhir, A., Samarani, S., Amre, D., Duval, M., Haddad, E., Sinnett, D., Leclerc, J.-M., Diorio, C., Ahmad, A., Journal of Leukocyte Biology, 2017, 10.1189/jlb.5RU0816-341R
A randomized double-blind placebo-controlled trial of the effect of Vitamin D3 supplementation on breast density in premenopausal women, Brisson, J., Bérubé, S., Diorio, C., Mâsse, B., Lemieux, J., Duchesne, T., Delvin, E., Vieth, R., Yaffe, M.J., Chiquette, J., Cancer Epidemiology Biomarkers and Prevention, 2017, 10.1158/1055-9965.EPI-17-0249
Adiposity, breast density, and breast cancer risk: Epidemiological and biological considerations, Soguel, L., Durocher, F., Tchernof, A., Diorio, C., European Journal of Cancer Prevention, 2017, 10.1097/CEJ.0000000000000310
Association between expression of inflammatory markers in normal breast tissue and mammographic density among premenopausal and postmenopausal women, Hanna, M., Dumas, I., Orain, M., Jacob, S., Têtu, B., Sanschagrin, F., Bureau, A., Poirier, B., Diorio, C., Menopause, 2017, 10.1097/GME.0000000000000794
Association between local inflammation and breast tissue age-related lobular involution among premenopausal and postmenopausal breast cancer patients, Hanna, M., Dumas, I., Orain, M., Jacob, S., Têtu, B., Sanschagrin, F., Bureau, A., Poirier, B., Diorio, C., PLoS ONE, 2017, 10.1371/journal.pone.0183579
Concordance of HER2 immunohistochemistry and fluorescence in situ hybridization using tissue microarray in breast cancer, Furrer, D., Jacob, S., Caron, C., Sanschagrin, F., Provencher, L., Diorio, C., Anticancer Research, 2017, 10.21873/anticanres.11701
Evaluation of Antioxidant Intakes in Relation to Inflammatory Markers Expression Within the Normal Breast Tissue of Breast Cancer Patients, Larouche, D., Hanna, M., Chang, S.-L., Jacob, S., Têtu, B., Diorio, C., Integrative Cancer Therapies, 2017, 10.1177/1534735416676584
How Wide Should Margins Be for Phyllodes Tumors of the Breast?, Tremblay-LeMay, R., Hogue, J.-C., Provencher, L., Poirier, B., Poirier, É., Laberge, S., Diorio, C., Desbiens, C., Breast Journal, 2017, 10.1111/tbj.12727
In Reply, Hanna, M., Diorio, C., Menopause, 2017, 10.1097/GME.0000000000000877
MCM2: An alternative to Ki-67 for measuring breast cancer cell proliferation, Yousef, E.M., Furrer, D., Laperriere, D.L., Tahir, M.R., Mader, S., DIorio, C., Gaboury, L.A., Modern Pathology, 2017, 10.1038/modpathol.2016.231
Prognostic and predictive value of low estrogen receptor expression in breast cancer, Bouchard-Fortier, A., Provencher, L., Blanchette, C., Diorio, C., Current Oncology, 2017, 10.3747/co.24.3238

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Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009

Anna Burguin - Doctorat - En cours
Elissar Issa - Doctorat - En cours
Annie Bourassa - Maitrîse avec mémoire - En cours
Juliette Bherer - Maitrîse avec mémoire - En cours
Kaoutar Ennour-Idrissi - Doctorat - En cours
Codjo Djignéfa Djade - Doctorat - En cours
Laetitia Madjri - Maitrîse avec mémoire - En cours
Farida Hamidou Farida Hamidou - Maitrîse avec mémoire - En cours
Dzevahira Dzevka Dragic - Doctorat - En cours
Alisson Clemenceau - Doctorat - En cours
Isabelle Dumas - Maitrîse avec mémoire - 2011/01
Caroline Duchaine - Maitrîse avec mémoire - 2014/05
Antoine Bouchard-Fortier - Maitrîse avec mémoire - 2015/05
Mirette Hanna - Doctorat - 2015/05
Ludivine Soguel Alexander - Maitrîse avec mémoire - 2015/09
Sofia Laforest - Maitrîse avec mémoire - 2016/05
Daniela Furrer Soliz Urrutia - Maitrîse avec mémoire - 2016/09
Danielle Larouche - Maitrîse avec mémoire - 2017/01
Ferial Amira Slim - Maitrîse avec mémoire - 2018/05
Vanina Sandy Tchuente Nguedem - Maitrîse avec mémoire - 2018/09
Charu Kothari - Doctorat - 2021/01
Jessica Morin-Buote - Maitrîse avec mémoire - 2021/05
Mamady Magassouba - Maitrîse avec mémoire - 2022/05

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.

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