Découvrez nos professeurs et professeures!
Amélie Fradet-Turcotte
Professeure titulaire
Centre de recherche sur le cancer
Centre de recherche du CHU de Québec - Université Laval
Centre de recherche en infectiologie
Contribution à la recherche
Thématiques de recherche de la Faculté de médecine
- Immunologie-infectiologie
- Oncologie
Domaines de recherche
- Biologie cellulaire, n.c.a.
- Virologie
- Cancer, n.c.a.
- Génétique du cancer
- Études sur les acides nucléiques
- Cibles moléculaires du cancer
- Interactions intramoléculaires
- Enzymes (y compris leurs cinétiques et mécanismes, et les biocatalyseurs)
- Biochimie, n.c.a.
Projets de recherche en cours
- Developing tools to study the role of chromatin remodelers during DNA double-strand break signalling and repair - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2025-04-01 au 2030-03-31
- Biochemical and structural studies of poly-TPR containing proteins involved in epigenetic signalling - Instituts de recherche en santé du Canada - Subvention Projet, Université d'Ottawa, co-chercheur - 2024-10-01 au 2029-09-30
- Chaire de recherche du Canada en virologie moléculaire et instabilité génomique - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2022-09-01 au 2027-10-31
- Unraveling the molecular mechanisms that promote replication stress and resistance to chemoradiation in oropharyngeal cancer caused by human papillomavirus - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2022-04-01 au 2027-03-31
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Financements des 2 dernières années
- Collaboration entre les laboratoires d’Amélie Fradet-Turcotte (AFT) et Louis Flamand (LF) sur l’étude des mécanismes de réponses aux dommages à l’ADN et les infections virales - Université Laval - Fonds internes - BDR - Contributions, co-chercheur - 2023-04-24 au 2024-04-23
- Deciphering the impact of chromatin modifications on DNA repair processes. - Conseil de recherches en sciences naturelles et génie Canada, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2016-04-01 au 2022-03-31
- Fonds Jeanne-et-Jean-Louis-Lévesque en soutien à la Chaire de recherche en virologie moléculaire et instabilité génomique - Fondation de l'Université Laval, chercheur principal - 2017-03-01 au 2022-02-28
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Publications
- A genetically encoded inhibitor of 53BP1 to stimulate homology-based gene editing, Daniel Durocher, Frank Sicheri, Sachdev S Sidhu, Timothy F Ng, Michal Zimmermann, Andreas Ernst, Meagan Munro, Andrew Vorobyov, Marcus D Wilson, Sylvie M Noordermeer, Wei Zhang, Yu-Chi Juang, Nathalie Moatti, Alexandre Orthwein, Amelie Fradet-Turcotte, Leo Wan, Marella Canny, 2016, 10.1101/060954
- A Quantitative and High-Throughput Assay of Human Papillomavirus DNA Replication, Jacques Archambault, Amélie Fradet-Turcotte, David Gagnon, Cervical Cancer, 2014, 10.1007/978-1-4939-2013-6_23
- A Conserved Amphipathic Helix in the N-Terminal Regulatory Region of the Papillomavirus E1 Helicase Is Required for Efficient Viral DNA Replication, J. Archambault, J. G. Omichinski, F. Bergeron-Labrecque, P. Di Lello, A. Fradet-Turcotte, G. Morin, Journal of Virology, 2011, 10.1128/jvi.01829-10
- Two redundant ubiquitin‐dependent pathways of BRCA1 localization to DNA damage sites, Daniel Durocher, Amélie Fradet‐Turcotte, Sylvie M Noordermeer, Anne Margriet Heijink, Salomé Adam, Natasha Chaudhary, Alana Sherker, EMBO reports, 2021, 10.15252/embr.202153679
- The immediate early protein 1 of human herpesvirus 6B counteracts ATM activation in an NBS1-dependent manner, Amélie Fradet-Turcotte, Louis Flamand, Annie Gravel, Andréanne Blondeau, Julien Dessapt, Élise G. Lavoie, Vincent Tremblay, Élise Biquand, Vanessa Collin, 2021, 10.1101/2021.07.31.454588
- Two redundant ubiquitin-dependent pathways of BRCA1 localization to DNA damage sites, Daniel Durocher, Amélie Fradet-Turcotte, Sylvie M. Noordermeer, Salomé Adam, Natasha Chaudhary, Alana Sherker, 2021, 10.1101/2021.07.21.452958
- The TUDOR domain of SMN is an H3K79me1histone mark reader, Patrick Lomonte, Jocelyn Côté, Amélie Fradet-Turcotte, Armelle Corpet, Karine Jacquet, Maxime Galloy, Aimé Boris Kimenyi Ishimwe, Olivier Binda, 2022, 10.1101/2022.10.06.511070
- Human papillomaviruses activate caspases upon epithelial differentiation to induce viral genome amplification, L. A. Laimins, J. Archambault, A. Fradet-Turcotte, C. A. Moody, Proceedings of the National Academy of Sciences, 2007, 10.1073/pnas.0707947104
- A Screen for Epstein-Barr Virus Proteins That Inhibit the DNA Damage Response Reveals a Novel Histone Binding Protein, Lori Frappier, Dong-Yan Jin, Amelie Fradet-Turcotte, Jack Greenblatt, Edyta Marcon, Ivan Borozan, Eric I. Campos, Ariane Leblanc-Lacroix, Qingtang Shen, Justine Sitz, Ting-Hin Ho, Journal of Virology, 2018, 10.1128/JVI.00262-18
- Characterization of papillomavirus E1 helicase mutants defective for interaction with the SUMO-conjugating enzyme Ubc9, Jacques Archambault, Peter M. Howley, Steve Titolo, Karine Brault, Amélie Fradet-Turcotte, Virology, 2009, 10.1016/j.virol.2009.09.020
- 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark, Daniel Durocher, Frank Sicheri, Sylvie M. Noordermeer, Julianne Kitevski-LeBlanc, Marie-Claude Landry, Hao Huang, Charles C. Y. Leung, Alexandre Orthwein, Cristina Escribano-Díaz, Marella D. Canny, Amélie Fradet-Turcotte, Nature, 2013, 10.1038/nature12318
- Mitosis Inhibits DNA Double-Strand Break Repair to Guard Against Telomere Fusions, D. Durocher, C. Escribano-Diaz, J. Strecker, C. M. Brun, M. D. Canny, S. M. Noordermeer, A. Fradet-Turcotte, A. Orthwein, Science, 2014, 10.1126/science.1248024
- RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks, A. Hakem, R. Hakem, B. Raught, G. S. Stewart, A. Fradet-Turcotte, S. Panier, G. Maire, T. Srikumar, S. El Ghamrasni, T. Bohgaki, M. Bohgaki, Proceedings of the National Academy of Sciences, 2013, 10.1073/pnas.1320302111
- Tandem Protein Interaction Modules Organize the Ubiquitin-Dependent Response to DNA Double-Strand Breaks, Daniel Durocher, Cheryl H. Arrowsmith, Lilia Kaustov, Charles C.Y. Leung, Amélie Fradet-Turcotte, Yosuke Ichijima, Stephanie Panier, Molecular Cell, 2012, 10.1016/j.molcel.2012.05.045
- A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice, Daniel Durocher, Dongyi Xu, Marella D. Canny, Meagan Munro, Adam P. Rosebrock, Michael A. Cook, Ján Tkáč, Jordan T.F. Young, Mengtan Xing, Amélie Fradet-Turcotte, Alexandre Orthwein, Cristina Escribano-Díaz, Molecular Cell, 2013, 10.1016/j.molcel.2013.01.001
- p53 and TFIIE share a common binding site on the Tfb1/p62 subunit of TFIIH, J. G. Omichinski, P. Legault, J. Archambault, A. Fradet-Turcotte, E. Malitskaya, C. Langlois, C. Mas, L. M. Miller Jenkins, P. Di Lello, Proceedings of the National Academy of Sciences, 2007, 10.1073/pnas.0707892105
- Structure-Based Analysis of the Interaction between the Simian Virus 40 T-Antigen Origin Binding Domain and Single-Stranded DNA, P. A. Bullock, J. Archambault, A. Bohm, A. Fradet-Turcotte, P. J. Phelan, G. Meinke, Journal of Virology, 2010, 10.1128/jvi.01738-10
- Inhibition of Human Papillomavirus DNA Replication by an E1-Derived p80/UAF1-Binding Peptide, J. Archambault, J. G. Omichinski, M. Lussier-Price, A. Fradet-Turcotte, M. Lehoux, Journal of Virology, 2012, 10.1128/jvi.07003-11
- The structural basis of modified nucleosome recognition by 53BP1, Daniel Durocher, John L. Rubinstein, Frank Sicheri, Sylvie M. Noordermeer, Andrea McEwan, Jean-Philippe Julien, Alana Sherker, Amélie Fradet-Turcotte, Samir Benlekbir, Marcus D. Wilson, Nature, 2016, 10.1038/nature18951
- Development of quantitative and high-throughput assays of polyomavirus and papillomavirus DNA replication, Jacques Archambault, Peter A. Bullock, Michaël Lehoux, Geneviève Morin, Amélie Fradet-Turcotte, Virology, 2010, 10.1016/j.virol.2009.12.026
- Model for T-Antigen-Dependent Melting of the Simian Virus 40 Core Origin Based on Studies of the Interaction of the Beta-Hairpin with DNA, P. A. Bullock, A. Bohm, J. Archambault, A. Fradet-Turcotte, P. J. Phelan, S. Moine, D. K. Reese, G. Meinke, A. Kumar, Journal of Virology, 2007, 10.1128/jvi.02451-06
- BRCA2 functions: from DNA repair to replication fork stabilization, Alexandre Orthwein, Damien Grapton, Justine Sitz, Amélie Fradet-Turcotte, Endocrine-Related Cancer, 2016, 10.1530/erc-16-0297
- High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities, Jason Moffat, Stephane Angers, Daniel Durocher, Olivia S. Rissland, Frederick P. Roth, Sachdev Sidhu, Peter Dirks, Patricia Mero, Song Sun, Amelie Fradet-Turcotte, Michal Zimmermann, Monika Mis, Graham MacLeod, Kevin R. Brown, Zachary Steinhart, Michael Aregger, Megha Chandrashekhar, Traver Hart, Cell, 2015, 10.1016/j.cell.2015.11.015
- Nuclear Accumulation of the Papillomavirus E1 Helicase Blocks S-Phase Progression and Triggers an ATM-Dependent DNA Damage Response, J. Archambault, L. A. Laimins, M. Lehoux, C. A. Moody, F. Bergeron-Labrecque, A. Fradet-Turcotte, Journal of Virology, 2011, 10.1128/jvi.00542-11
- Methods to Assess the Nucleocytoplasmic Shuttling of the HPV E1 Helicase and Its Effects on Cellular Proliferation and Induction of a DNA Damage Response, Jacques Archambault, Amélie Fradet-Turcotte, Michaël Lehoux, Cervical Cancer, 2014, 10.1007/978-1-4939-2013-6_5
- Human Papillomavirus E1 Helicase Interacts with the WD Repeat Protein p80 To Promote Maintenance of the Viral Genome in Keratinocytes, J. Archambault, L. A. Laimins, B. Coulombe, G. G. Poirier, S. Joubert, M. Lehoux, C. M. D'Abramo, A. Fradet-Turcotte, C. Moody, A. Cote-Martin, Journal of Virology, 2007, 10.1128/jvi.01405-07
- The RNF168 paralog RNF169 defines a new class of ubiquitylated-histone reader involved in the response to DNA damage, Lewis E Kay, Daniel Durocher, Michele Vendruscolo, John L Rubinstein, Cheryl H Arrowsmith, Hugo van Ingen, Marella D Canny, Shili Duan, Stephanie Panier, Tairan Yuwen, Guillem Portella, Marcus D Wilson, Predrag Kukic, Amélie Fradet-Turcotte, Julianne Kitevski-LeBlanc, eLife, 2017, 10.7554/elife.23872
- Quantitative Analysis of the Binding of Simian Virus 40 Large T Antigen to DNA, J. Archambault, P. A. Bullock, S. Joubert, C. Vincent, A. Fradet-Turcotte, Journal of Virology, 2007, 10.1128/jvi.00384-07
- The TUDOR domain of SMN is an H3K79me1histone mark reader, Patrick Lomonte, Jocelyn Côté, Amélie Fradet-Turcotte, Armelle Corpet, Karine Jacquet, Maxime Galloy, Aimé Boris Kimenyi Ishimwe, Olivier Binda, Life Science Alliance, 2023, 10.26508/lsa.202201752
- Proteasomal Degradation of the Papillomavirus E2 Protein Is Inhibited by Overexpression of Bromodomain-Containing Protein 4, J. Archambault, S. Torre, A. Fradet-Turcotte, H. Senechal, S. Joubert, D. Gagnon, Journal of Virology, 2009, 10.1128/jvi.02468-08
- Nuclear Export of Human Papillomavirus Type 31 E1 Is Regulated by Cdk2 Phosphorylation and Required for Viral Genome Maintenance, J. Archambault, L. A. Laimins, C. Moody, A. Fradet-Turcotte, Journal of Virology, 2010, 10.1128/jvi.01445-10
- Structure-based design of a disulfide-linked oligomeric form of the simian virus 40 (SV40) large T antigen DNA-binding domain, Peter A. Bullock, Jacques Archambault, Amélie Fradet-Turcotte, Paul Phelan, Gretchen Meinke, Acta Crystallographica Section D Biological Crystallography, 2011, 10.1107/s0907444911014302
- The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation, Jacques Côté, Daniel Durocher, Yannick Doyon, Gaëlle Legube, Tej K. Pandita, Anne-Claude Gingras, Pauline Herst, Raj K. Pandita, Eric Paquet, Céline Roques, Jean-Philippe Lambert, Nikita Avvakumov, Amélie Fradet-Turcotte, Karine Jacquet, Molecular Cell, 2016, 10.1016/j.molcel.2016.03.031
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Contribution à l'enseignement aux cycles supérieurs
Étudiant(e)s dirigé(e)s*
Depuis 2020/07- Ottilie Le Doeuff - Doctorat - En cours
- Nandana Nandakumar - Doctorat - En cours
- Emile Clerf - Doctorat - En cours
- Marie-Anne Bérubé - Maîtrise avec mémoire - En cours
- Cloé Laflamme - Maîtrise avec mémoire - En cours
- Maxime Galloy - Doctorat - En cours
- Justine Sitz - Doctorat - 2021/09
- Sophie Anne Blanchet - Maîtrise avec mémoire - 2022/01
- Vincent Tremblay - Maîtrise avec mémoire - 2022/09
- Julien Dessapt - Doctorat - 2024/05
Encadrement d'étudiant(e)s
Direction de recherche dans les domaines suivants :
- Biologie cellulaire et moléculaire
- Médecine moléculaire
*Les supervisions d’étudiant(e)s de 1er cycle en
stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées
ultérieurement.