Amélie Fradet-Turcotte
Professeure agrégée
Centre de recherche sur le cancer
Centre de recherche du CHU de Québec - Université Laval
Contribution à la recherche
Axe de recherche de l'Université Laval :
Santé et bien-être durables
Thématiques de recherche de la Faculté de médecine :
Immunologie-infectiologie
Oncologie
Domaines et intérêts de recherche du (de la) professeur(e) :
Cancer
- Cancer de la tête et du cou
- Cancer de l'appareil reproducteur
- Cancer du sein
- Carcinogénèse
- Chimiothérapie
- Gène suppresseur
- Oncogènes
- Signalisation cellulaire et cancer
Cellulaire
- Cellule
- Chromosome
Génomique et protéomique
- Mécanismes biologiques et biochimiques
Projets de recherche
- Unraveling the molecular mechanisms that promote replication stress and resistance to chemoradiation in oropharyngeal cancer caused by human papillomavirus - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2022-04-01 au 2027-03-31
- Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
- Deciphering the impact of chromatin modifications on DNA repair processes. - Conseil de recherches en sciences naturelles et génie Canada, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2016-04-01 au 2022-03-31
- Defining the molecular basis of chemoradiation sensitivity in HPV+ head and neck cancers - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2017-04-01 au 2022-03-31
- Chaire de recherche du Canada en virologie moléculaire et instabilité génomique - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2017-03-01 au 2022-02-28
- Fonds Jeanne-et-Jean-Louis-Lévesque en soutien à la Chaire de recherche en virologie moléculaire et instabilité génomique - Fondation de l'Université Laval, chercheur principal - 2017-03-01 au 2022-02-28
- Chaire de recherche du Canada en virologie moléculaire et instabilité génomique - Instituts de recherche en santé du Canada - Allocation de recherche pour les Chaires de recherche du Canada Niveau 2 aux premiers termes, chercheur principal - 2019-01-11 au 2022-02-28
- Characterisation of PTM-associated mutations that alter signaling network in breast and ovarian cancers - Société de recherche sur le cancer, Instituts de recherche en santé du Canada - Subvention de fonctionnement, chercheur principal - 2019-09-01 au 2021-08-31
- Engineering HPV oncoprotein E6 for inhibitors of cancer progression - Société de recherche sur le cancer, University of Guelph, co-chercheur - 2019-08-01 au 2021-07-31
...
Publications
- Two redundant ubiquitin‐dependent pathways of BRCA1 localization to DNA damage sites, Alana Sherker, Natasha Chaudhary, Salomé Adam, Anne Margriet Heijink, Sylvie M Noordermeer, Amélie Fradet‐Turcotte, Daniel Durocher, EMBO reports, 2021, 10.15252/embr.202153679
- The immediate early protein 1 of the human herpesvirus 6B counteracts NBS1 and prevents homologous recombination repair pathways, Vanessa Collin, Élise Biquand, Vincent Tremblay, Élise Gaudreau-Lavoie, Julien Dessapt, Annie Gravel, Louis Flamand, Amélie Fradet-Turcotte, 2021, 10.1101/2021.07.31.454588
- Two redundant ubiquitin-dependent pathways of BRCA1 localization to DNA damage sites, Alana Sherker, Natasha Chaudhary, Salomé Adam, Sylvie M. Noordermeer, Amélie Fradet-Turcotte, Daniel Durocher, 2021, 10.1101/2021.07.21.452958
- A Screen for Epstein-Barr Virus Proteins That Inhibit the DNA Damage Response Reveals a Novel Histone Binding Protein, Ting-Hin Ho, Justine Sitz, Qingtang Shen, Ariane Leblanc-Lacroix, Eric I. Campos, Ivan Borozan, Edyta Marcon, Jack Greenblatt, Amelie Fradet-Turcotte, Dong-Yan Jin, Lori Frappier, Journal of Virology, 2018, 10.1128/JVI.00262-18
- The RNF168 paralog RNF169 defines a new class of ubiquitylated-histone reader involved in the response to DNA damage, Julianne Kitevski-LeBlanc, Amélie Fradet-Turcotte, Predrag Kukic, Marcus D Wilson, Guillem Portella, Tairan Yuwen, Stephanie Panier, Shili Duan, Marella D Canny, Hugo van Ingen, Cheryl H Arrowsmith, John L Rubinstein, Michele Vendruscolo, Daniel Durocher, Lewis E Kay, eLife, 2017, 10.7554/elife.23872
- BRCA2 functions: from DNA repair to replication fork stabilization, Amélie Fradet-Turcotte, Justine Sitz, Damien Grapton, Alexandre Orthwein, Endocrine-Related Cancer, 2016, 10.1530/erc-16-0297
- The structural basis of modified nucleosome recognition by 53BP1, Marcus D. Wilson, Samir Benlekbir, Amélie Fradet-Turcotte, Alana Sherker, Jean-Philippe Julien, Andrea McEwan, Sylvie M. Noordermeer, Frank Sicheri, John L. Rubinstein, Daniel Durocher, Nature, 2016, 10.1038/nature18951
- A genetically encoded inhibitor of 53BP1 to stimulate homology-based gene editing, Marella Canny, Leo Wan, Amelie Fradet-Turcotte, Alexandre Orthwein, Nathalie Moatti, Yu-Chi Juang, Wei Zhang, Sylvie M Noordermeer, Marcus D Wilson, Andrew Vorobyov, Meagan Munro, Andreas Ernst, Michal Zimmermann, Timothy F Ng, Sachdev S Sidhu, Frank Sicheri, Daniel Durocher, 2016, 10.1101/060954
- The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation, Karine Jacquet, Amélie Fradet-Turcotte, Nikita Avvakumov, Jean-Philippe Lambert, Céline Roques, Raj K. Pandita, Eric Paquet, Pauline Herst, Anne-Claude Gingras, Tej K. Pandita, Gaëlle Legube, Yannick Doyon, Daniel Durocher, Jacques Côté, Molecular Cell, 2016, 10.1016/j.molcel.2016.03.031
- High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities, Traver Hart, Megha Chandrashekhar, Michael Aregger, Zachary Steinhart, Kevin R. Brown, Graham MacLeod, Monika Mis, Michal Zimmermann, Amelie Fradet-Turcotte, Song Sun, Patricia Mero, Peter Dirks, Sachdev Sidhu, Frederick P. Roth, Olivia S. Rissland, Daniel Durocher, Stephane Angers, Jason Moffat, Cell, 2015, 10.1016/j.cell.2015.11.015
- A Quantitative and High-Throughput Assay of Human Papillomavirus DNA Replication, David Gagnon, Amélie Fradet-Turcotte, Jacques Archambault, Cervical Cancer, 2014, 10.1007/978-1-4939-2013-6_23
- Methods to Assess the Nucleocytoplasmic Shuttling of the HPV E1 Helicase and Its Effects on Cellular Proliferation and Induction of a DNA Damage Response, Michaël Lehoux, Amélie Fradet-Turcotte, Jacques Archambault, Cervical Cancer, 2014, 10.1007/978-1-4939-2013-6_5
- Mitosis Inhibits DNA Double-Strand Break Repair to Guard Against Telomere Fusions, A. Orthwein, A. Fradet-Turcotte, S. M. Noordermeer, M. D. Canny, C. M. Brun, J. Strecker, C. Escribano-Diaz, D. Durocher, Science, 2014, 10.1126/science.1248024
- 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark, Amélie Fradet-Turcotte, Marella D. Canny, Cristina Escribano-Díaz, Alexandre Orthwein, Charles C. Y. Leung, Hao Huang, Marie-Claude Landry, Julianne Kitevski-LeBlanc, Sylvie M. Noordermeer, Frank Sicheri, Daniel Durocher, Nature, 2013, 10.1038/nature12318
- A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice, Cristina Escribano-Díaz, Alexandre Orthwein, Amélie Fradet-Turcotte, Mengtan Xing, Jordan T.F. Young, Ján Tkáč, Michael A. Cook, Adam P. Rosebrock, Meagan Munro, Marella D. Canny, Dongyi Xu, Daniel Durocher, Molecular Cell, 2013, 10.1016/j.molcel.2013.01.001
- RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks, M. Bohgaki, T. Bohgaki, S. El Ghamrasni, T. Srikumar, G. Maire, S. Panier, A. Fradet-Turcotte, G. S. Stewart, B. Raught, A. Hakem, R. Hakem, Proceedings of the National Academy of Sciences, 2013, 10.1073/pnas.1320302111
- Tandem Protein Interaction Modules Organize the Ubiquitin-Dependent Response to DNA Double-Strand Breaks, Stephanie Panier, Yosuke Ichijima, Amélie Fradet-Turcotte, Charles C.Y. Leung, Lilia Kaustov, Cheryl H. Arrowsmith, Daniel Durocher, Molecular Cell, 2012, 10.1016/j.molcel.2012.05.045
- Inhibition of Human Papillomavirus DNA Replication by an E1-Derived p80/UAF1-Binding Peptide, M. Lehoux, A. Fradet-Turcotte, M. Lussier-Price, J. G. Omichinski, J. Archambault, Journal of Virology, 2012, 10.1128/jvi.07003-11
- Nuclear Accumulation of the Papillomavirus E1 Helicase Blocks S-Phase Progression and Triggers an ATM-Dependent DNA Damage Response, A. Fradet-Turcotte, F. Bergeron-Labrecque, C. A. Moody, M. Lehoux, L. A. Laimins, J. Archambault, Journal of Virology, 2011, 10.1128/jvi.00542-11
- Structure-based design of a disulfide-linked oligomeric form of the simian virus 40 (SV40) large T antigen DNA-binding domain, Gretchen Meinke, Paul Phelan, Amélie Fradet-Turcotte, Jacques Archambault, Peter A. Bullock, Acta Crystallographica Section D Biological Crystallography, 2011, 10.1107/s0907444911014302
- A Conserved Amphipathic Helix in the N-Terminal Regulatory Region of the Papillomavirus E1 Helicase Is Required for Efficient Viral DNA Replication, G. Morin, A. Fradet-Turcotte, P. Di Lello, F. Bergeron-Labrecque, J. G. Omichinski, J. Archambault, Journal of Virology, 2011, 10.1128/jvi.01829-10
- Structure-Based Analysis of the Interaction between the Simian Virus 40 T-Antigen Origin Binding Domain and Single-Stranded DNA, G. Meinke, P. J. Phelan, A. Fradet-Turcotte, A. Bohm, J. Archambault, P. A. Bullock, Journal of Virology, 2010, 10.1128/jvi.01738-10
- Nuclear Export of Human Papillomavirus Type 31 E1 Is Regulated by Cdk2 Phosphorylation and Required for Viral Genome Maintenance, A. Fradet-Turcotte, C. Moody, L. A. Laimins, J. Archambault, Journal of Virology, 2010, 10.1128/jvi.01445-10
- Development of quantitative and high-throughput assays of polyomavirus and papillomavirus DNA replication, Amélie Fradet-Turcotte, Geneviève Morin, Michaël Lehoux, Peter A. Bullock, Jacques Archambault, Virology, 2010, 10.1016/j.virol.2009.12.026
- Proteasomal Degradation of the Papillomavirus E2 Protein Is Inhibited by Overexpression of Bromodomain-Containing Protein 4, D. Gagnon, S. Joubert, H. Senechal, A. Fradet-Turcotte, S. Torre, J. Archambault, Journal of Virology, 2009, 10.1128/jvi.02468-08
- Characterization of papillomavirus E1 helicase mutants defective for interaction with the SUMO-conjugating enzyme Ubc9, Amélie Fradet-Turcotte, Karine Brault, Steve Titolo, Peter M. Howley, Jacques Archambault, Virology, 2009, 10.1016/j.virol.2009.09.020
- Human Papillomavirus E1 Helicase Interacts with the WD Repeat Protein p80 To Promote Maintenance of the Viral Genome in Keratinocytes, A. Cote-Martin, C. Moody, A. Fradet-Turcotte, C. M. D'Abramo, M. Lehoux, S. Joubert, G. G. Poirier, B. Coulombe, L. A. Laimins, J. Archambault, Journal of Virology, 2007, 10.1128/jvi.01405-07
- Human papillomaviruses activate caspases upon epithelial differentiation to induce viral genome amplification, C. A. Moody, A. Fradet-Turcotte, J. Archambault, L. A. Laimins, Proceedings of the National Academy of Sciences, 2007, 10.1073/pnas.0707947104
- Quantitative Analysis of the Binding of Simian Virus 40 Large T Antigen to DNA, A. Fradet-Turcotte, C. Vincent, S. Joubert, P. A. Bullock, J. Archambault, Journal of Virology, 2007, 10.1128/jvi.00384-07
- Model for T-Antigen-Dependent Melting of the Simian Virus 40 Core Origin Based on Studies of the Interaction of the Beta-Hairpin with DNA, A. Kumar, G. Meinke, D. K. Reese, S. Moine, P. J. Phelan, A. Fradet-Turcotte, J. Archambault, A. Bohm, P. A. Bullock, Journal of Virology, 2007, 10.1128/jvi.02451-06
- p53 and TFIIE share a common binding site on the Tfb1/p62 subunit of TFIIH, P. Di Lello, L. M. Miller Jenkins, C. Mas, C. Langlois, E. Malitskaya, A. Fradet-Turcotte, J. Archambault, P. Legault, J. G. Omichinski, Proceedings of the National Academy of Sciences, 2007, 10.1073/pnas.0707892105
...
Contribution à l'enseignement aux cycles supérieurs
Étudiant(e)s dirigé(e)s*
Depuis 2009- Khadidiatou Mangou - Maitrîse avec mémoire - En cours
- Vincent Tremblay - Maitrîse avec mémoire - En cours
- Maxime Galloy - Doctorat - En cours
- Sophie Anne Blanchet - Doctorat - En cours
- Elise Marie Anne Danielle Biquand - Post-doctorat - En cours
- Justine Sitz - Doctorat - 2021/09
Encadrement d'étudiant(e)s pour les programmes suivants :
*Les supervisions d’étudiant(e)s de 1er cycle en
stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées
ultérieurement.