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Mariana Baz Etchebarne

Professeure adjointe

mariana.baz-etchebarne.1@ulaval.ca
Centre de recherche du CHU de Québec - Université Laval
Centre de recherche en infectiologie
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Contribution à la recherche

Projets de recherche

  • Canada Research Chair in Pre-pandemic and Pandemic viruses and therapeutic strategies - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2023-05-01 au 2028-04-29
  • Développement de tests sérologiques pour les virus respiratoires et les virus de la variole du singe. - CHU de Québec – Université Laval – CHUL - Développement de la recherche (FC), chercheur principal - 2023-04-01 au 2026-03-31
  • Aerosol Infection Research: Better mOdels to Reduce iNdoor Exposure (AIRBORNE) - Medical Research Future Fund - 2021 Coronavirus Research Response – Covid-19 Treatment Access and Public Health Activities, The University of Melbourne, co-chercheur - 2022-06-01 au 2025-05-30
  • Chaire de recherche Sentinelle Nord sur les virus pandémique et thérapies antivirales - Secrétariat des programmes interorganismes à l’intention des établissements - Fonds d'excellence en recherche Apogée Canada, chercheur principal - 2022-04-01 au 2025-03-31
  • Plateforme de laboratoire de niveau de confinement 3 pour la recherche sur les virus émergents - CHU de Québec – Université Laval – CHUL, Ministère de l'Économie et de l'Innovation - Appel de projets en appui aux plateformes technologiques stratégiques, co-chercheur - 2023-01-31 au 2025-03-31
  • Is treatment with a combination of licensed influenza antivirals superior to monotherapy for highly pathogenic H5N1 influenza virus from cattle? - Instituts de recherche en santé du Canada - Subvention catalyseur : Recherche « Une seule santé » sur la grippe aviaire, chercheur principal - 2024-04-01 au 2025-03-31
  • Virus pré-pandémiques et pandémiques et stratégies thérapeutiques - Ministère de la Santé et des Services sociaux, Fondation Canadienne pour l'innovation (La) - Fonds des leaders John-R.-Evans (FLJR), chercheur principal - 2023-04-01 au 2024-12-31
  • Optimization of a live microneutralization assay to evaluate antibody levels against mpox in vaccinated or infected individuals in Quebec - Université Laval - Fonds internes - BDR - Contributions, chercheur principal - 2023-04-24 au 2024-04-23
  • Preclinical proof of concept studies of a new generation of TLR7/8 agonist used in prevention against respiratory viruses and in immunotherapy against lung cancer - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2023-03-01 au 2024-02-29
  • Fonds de démarrage, Mariana Baz. La grippe à l'interface entre l'homme et l'animal: émergence et contrôle - CHU de Québec – Université Laval – CHUL, Fondation du CHU de Québec - Fonds de démarrage, chercheur principal - 2020-04-13 au 2023-04-12
  • Prevention of the immunopathology induced by SARS-CoV-2 - Instituts de recherche en santé du Canada - Subvention de fonctionnement : Possibilité de financement sur les nouveaux besoins prioritaires en recherche sur la COVID-19, co-chercheur - 2021-06-01 au 2022-05-31
  • Immunité cellulaire et séroprévalence des anticorps contre SARS-COV-2: Caratérisation de trois populations de travailleurs de l'alimentation - Agence de la santé publique du Canada, co-chercheur - 2020-11-01 au 2022-03-31
  • Innovative therapeutic approaches for the 2019-novel coronavirus - Instituts de recherche en santé du Canada, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Subvention de fonctionnement : Possibilité de financement canadienne pour une intervention de recherche rapide contre la maladie à coronavirus 2019 (COVID-19), co-chercheur - 2021-03-01 au 2022-02-28
  • Understanding the pathogenesis of COVID-19 - Instituts de recherche en santé du Canada, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Subvention de fonctionnement : Possibilité de financement canadienne pour une intervention de recherche rapide contre la maladie à coronavirus 2019 (COVID-19), co-chercheur - 2020-03-01 au 2021-02-28

Publications

  • Evolution of Oseltamivir Resistance Mutations in Influenza A(H1N1) and A(H3N2) Viruses during Selection in Experimentally Infected Mice, , Antimicrobial Agents and Chemotherapy, 2014, 10.1128/aac.02956-14
  • Structural Insight into NS5 of Zika Virus Leading to the Discovery of MTase Inhibitors, , Journal of the American Chemical Society, 2016, 10.1021/jacs.6b10399
  • Emergence of Oseltamivir-Resistant Pandemic H1N1 Virus during Prophylaxis, , New England Journal of Medicine, 2009, 10.1056/nejmc0910060
  • Development of a High-Yield Live Attenuated H7N9 Influenza Virus Vaccine That Provides Protection against Homologous and Heterologous H7 Wild-Type Viruses in Ferrets, , Journal of Virology, 2014, 10.1128/jvi.00100-14
  • Synergistic PA and HA mutations confer mouse adaptation of a contemporary A/H3N2 influenza virus, , Scientific Reports, 2019, 10.1038/s41598-019-51877-4
  • Development of a universal influenza A vaccine based on the M2e peptide fused to the papaya mosaic virus (PapMV) vaccine platform, , Vaccine, 2008, 10.1016/j.vaccine.2008.04.052
  • Intranasal Delivery of Quillaja brasiliensis Saponin-Based Nanoadjuvants Improve Humoral Immune Response of Influenza Vaccine in Aged Mice, Mariana Baz, Silvina Rossi, José A. Chabalgoity, Gabriel García, Florencia García, Fernando Silveira, Vaccines, 2024, 10.3390/vaccines12080902
  • The quest for a nanoparticle-based vaccine inducing broad protection to influenza viruses, , Nanomedicine: Nanotechnology, Biology and Medicine, 2018, 10.1016/j.nano.2018.08.010
  • Activity of the Oral Neuraminidase Inhibitor A-322278 against the Oseltamivir-Resistant H274Y (A/H1N1) Influenza Virus Mutant in Mice, , Antimicrobial Agents and Chemotherapy, 2009, 10.1128/aac.01276-08
  • In vitro susceptibility of geographically and temporally distinct zika viruses to favipiravir and ribavirin, , Antiviral Therapy, 2017, 10.3851/imp3180
  • An addition to treatment options for avian influenza A H5N1?, , The Lancet Infectious Diseases, 2015, 10.1016/s1473-3099(15)70019-8
  • Effects of Different Drug Combinations in Immunodeficient Mice Infected with an Influenza A/H3N2 Virus, , Microorganisms, 2020, 10.3390/microorganisms8121968
  • Infections by Human Coronavirus-NL in Hospitalized Children, , The Pediatric Infectious Disease Journal, 2005, 10.1097/01.inf.0000183743.68569.c7
  • Predominant role of IPS-1 over TRIF adaptor proteins in early innate immune response against Zika virus in mice, , Journal of General Virology, 2018, 10.1099/jgv.0.000992
  • Influenza B viruses isolated in Uruguay during the 2002–2005 seasons: Genetic relations and vaccine strain match, , Virus Research, 2007, 10.1016/j.virusres.2006.08.002
  • Pre-Clinical Evaluation of the Antiviral Activity of Epigalocatechin-3-Gallate, a Component of Green Tea, against Influenza A(H1N1)pdm Viruses, Mariana Baz, Yves Desjardins, Nikita Deshpande, Paulina Koszalka, Harry Stannard, Viruses, 2023, 10.3390/v15122447
  • Activity of the neuraminidase inhibitor A-315675 against oseltamivir-resistant influenza neuraminidases of N1 and N2 subtypes, , Antiviral Research, 2008, 10.1016/j.antiviral.2007.08.008
  • In vitro and in vivo evidence of a potential A(H1N1)pdm09 antigenic drift mediated by escape mutations in the haemagglutinin Sa antigenic site, , Journal of General Virology, 2017, 10.1099/jgv.0.000800
  • In Vitro Combinations of Baloxavir Acid and Other Inhibitors against Seasonal Influenza A Viruses, , Viruses, 2020, 10.3390/v12101139
  • A Single Dose of an Avian H3N8 Influenza Virus Vaccine Is Highly Immunogenic and Efficacious against a Recently Emerged Seal Influenza Virus in Mice and Ferrets, , Journal of Virology, 2015, 10.1128/jvi.00280-15
  • A Live Attenuated Equine H3N8 Influenza Vaccine Is Highly Immunogenic and Efficacious in Mice and Ferrets, , Journal of Virology, 2015, 10.1128/jvi.02449-14
  • Preclinical and clinical developments for combination treatment of influenza, Mariana Baz, Kanta Subbarao, Paulina Koszalka, PLOS Pathogens, 2022, 10.1371/journal.ppat.1010481
  • Replication and Immunogenicity of Swine, Equine, and Avian H3 Subtype Influenza Viruses in Mice and Ferrets, , Journal of Virology, 2013, 10.1128/jvi.03520-12
  • Immunogenicity and tolerability of an inactivated and adjuvanted pandemic H1N1 influenza vaccine, in HIV-1-infected patients, , Vaccine, 2011, 10.1016/j.vaccine.2010.12.023
  • Reduced airborne transmission of oseltamivir-resistant pandemic A/H1N1 virus in ferrets, , Antiviral Therapy, 2011, 10.3851/imp1794
  • Characterization of drug-resistant recombinant influenza A/H1N1 viruses selected in vitro with peramivir and zanamivir, , Antiviral Research, 2007, 10.1016/j.antiviral.2006.10.012
  • Nonreplicating Influenza A Virus Vaccines Confer Broad Protection against Lethal Challenge, , mBio, 2015, 10.1128/mbio.01487-15
  • Effects of Different Adjuvants in the Context of Intramuscular and Intranasal Routes on Humoral and Cellular Immune Responses Induced by Detergent-Split A/H3N2 Influenza Vaccines in Mice, , Clinical and Vaccine Immunology, 2012, 10.1128/cvi.05441-11
  • Characterization of Multidrug-Resistant Influenza A/H3N2 Viruses Shed during 1 Year by an Immunocompromised Child, , Clinical Infectious Diseases, 2006, 10.1086/508777
  • Oseltamivir-Resistant Pandemic A/H1N1 Virus Is as Virulent as Its Wild-Type Counterpart in Mice and Ferrets, , PLoS Pathogens, 2010, 10.1371/journal.ppat.1001015
  • Seroconversion to Seasonal Influenza Viruses after A(H1N1)pdm09 Virus Infection, Quebec, Canada, , Emerging Infectious Diseases, 2012, 10.3201/eid1807.111680
  • Zika Virus Isolation, Purification, and Titration, , Methods in Molecular Biology, 2020, 10.1007/978-1-0716-0581-3_2
  • Longitudinal Influenza A Virus Screening of Retail Milk from Canadian Provinces (Rolling Updates), Angela L. Rasmussen, Jason Kindrachuk, Isaac Bogoch, Mustafa S. Jafri, Gabriela J. Rzeszutek, Jumari Snyman, Selena M. Sagan, Rodney S. Russell, Ryan Noyce, Craig McCormick, Sonya MacParland, Andrew S. Lang, Jeffrey B Joy, Francois Jean, Tom Hobman, Louis Flamand, Barbara Dowding, Mariana Baz, Jordan Wight, Hannah L. Wallace, 2024, 10.1101/2024.05.28.24308052
  • H5N1 vaccines in humans, , Virus Research, 2013, 10.1016/j.virusres.2013.05.006
  • Combination Therapy with Oseltamivir and Favipiravir Delays Mortality but Does Not Prevent Oseltamivir Resistance in Immunodeficient Mice Infected with Pandemic A(H1N1) Influenza Virus, , Viruses, 2018, 10.3390/v10110610
  • Effect of the Neuraminidase Mutation H274Y Conferring Resistance to Oseltamivir on the Replicative Capacity and Virulence of Old and Recent Human Influenza A(H1N1) Viruses, , The Journal of Infectious Diseases, 2010, 10.1086/650464
  • Household Transmission of the 2009 Pandemic A/H1N1 Influenza Virus: Elevated Laboratory‐Confirmed Secondary Attack Rates and Evidence of Asymptomatic Infections, , Clinical Infectious Diseases, 2010, 10.1086/656582
  • Antiviral Agents in Development for Zika Virus Infections, , Pharmaceuticals, 2019, 10.3390/ph12030101
  • Impact of R152K and R368K neuraminidase catalytic substitutions on in vitro properties and virulence of recombinant A(H1N1)pdm09 viruses, , Antiviral Research, 2018, 10.1016/j.antiviral.2018.04.009
  • ISCOM-like Nanoparticles Formulated with Quillaja brasiliensis Saponins Are Promising Adjuvants for Seasonal Influenza Vaccines, Fernando Silveira, Cibulski, S., Paulo Roehe;. Roehe, P.M.; Roehe, Paulo; Paulo Michel Roehe; , Mariana Baz, María Moreno, Mariana Rivera-Patron, Vaccines, 2021, 10.3390/vaccines9111350
  • Longitudinal Study on Seroprevalence and Immune Response to SARS-CoV-2 in a Population of Food and Retail Workers Through Transformation of ELISA Datasets, Joelle N. Pelletier, Daniela Quaglia, Sylvie Trottier, Marc-André Langlois, Jean-Francois Masson, Mariana Baz, Denis Boudreau, Caroline Gilbert, Kim Santerre, Mathieu Thériault, Yves Durocher, Matthew Stuible, Étienne Lavallée, Megan-Faye Parker, Abdelhadi Djaïleb, 2024, 10.1101/2024.01.27.24301877
  • Cohort Profile: Prospective Cohort to Study the COVID-19 Immune Response in Retail Workers in Québec, Canada (CISACOV), Sylvie Trottier, Denis Boudreau, Mariana Baz, Jean-François Masson, Caroline Gilbert, Joelle N. Pelletier, Samuel Rochette, Nicholas Brousseau, Mathieu Thériault, Kim Santerre, 2023, 10.1101/2023.08.18.23294172
  • Impact of the Baloxavir-Resistant Polymerase Acid I38T Substitution on the Fitness of Contemporary Influenza A(H1N1)pdm09 and A(H3N2) Strains, , The Journal of Infectious Diseases, 2020, 10.1093/infdis/jiz418
  • Development of Clade-Specific and Broadly Reactive Live Attenuated Influenza Virus Vaccines against Rapidly Evolving H5 Subtype Viruses, , Journal of Virology, 2017, 10.1128/jvi.00547-17
  • Evaluation of Serological Diagnostic Methods for the 2009 Pandemic Influenza A (H1N1) Virus, , Clinical and Vaccine Immunology, 2011, 10.1128/cvi.00449-10
  • A Novel Neuraminidase Deletion Mutation Conferring Resistance to Oseltamivir in Clinical Influenza A/H3N2 Virus, , The Journal of Infectious Diseases, 2009, 10.1086/595736

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Andrea Carolina Arroyave Saldarriaga - Maîtrise avec mémoire - En cours
  • V. Nougnanké Croix Aude Wantchecon - Maîtrise avec mémoire - En cours
  • Ahmed Sahli - Doctorat - En cours
  • Vonintsoa Lalaina Rahajamanana - Doctorat - En cours
  • Zeineb M'hamdi - Doctorat - 2021/09
*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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