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Louis Flamand

Professeur titulaire

Louis Flamand
louis.flamand@fmed.ulaval.ca
Centre de recherche en infectiologie
Centre de recherche du CHU de Québec - Université Laval
Centre de recherche en arthrite (ARThrite)
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Immunologie-infectiologie

Domaines et intérêts de recherche du (de la) professeur(e) :

Maladies infectieuses et immunitaires
  • Virus
  • Infections virales
  • Maladies infectieuses
  • Défense cellulaire
  • Leucocytes
  • Antigènes

Projets de recherche

  • Human herpesvirus 6 and chromosomal integration - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2023-04-01 au 2028-03-31
  • Dissecting the pathological consequences of neurological infections by herpesviruses, using human iPSC-derived cultures - Instituts de recherche en santé du Canada - Subvention Projet, University of Toronto, co-chercheur - 2021-04-01 au 2026-03-31
  • Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
  • Pathogenic roles of platelets in sepsis - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2020-03-01 au 2025-03-31
  • Collaboration entre les laboratoires d’Amélie Fradet-Turcotte (AFT) et Louis Flamand (LF) sur l’étude des mécanismes de réponses aux dommages à l’ADN et les infections virales - Université Laval - Fonds internes - BDR - Contributions, chercheur principal - 2023-04-24 au 2024-04-23
  • Conception d’anticorps humanisés neutralisants pour contrer l’herpès chez les greffés de cellules souches - CHU de Québec – Université Laval – CHUL - Aide à la recherche, chercheur principal - 2023-11-08 au 2024-03-31
  • Pillar 2: In vitro and in vivo Characterizations - Coronavirus Variants Rapid Response Network: CoVaRR-Net - Instituts de recherche en santé du Canada - Subvention de fonctionnement:Réseau des IRSC pour la recherche sur les nouveaux variants du COVID-19, Université d'Ottawa, co-chercheur - 2021-03-01 au 2023-03-31
  • The impact of antimalarial drugs in arthritis patients exposed to SARS-CoV-2- the CoVIRAL project - La société d'arthrite, co-chercheur - 2020-04-01 au 2023-03-31
  • COVID-19 Vaccine in Immunosuppressed Adults with Autoimmune Diseases / La réponse immunitaire au vaccin contre la COVID-19 chez des patients immunosupprimés en raison de maladies auto-immunes - Ministère de la Santé et des Services sociaux, McGill University, co-chercheur - 2021-03-16 au 2023-03-31
  • Soutenir les démarches de diffusion de l'appel à candidature CERC - Équipe Louis Flamand - Université Laval - Fonds internes - BDR - Contributions, chercheur principal - 2022-04-01 au 2023-03-31
  • Human herpesvirus 6 and chromosomal integration - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2018-04-01 au 2023-03-31
  • Booster dose of mRNA SARS-CoV-2 vaccine vs non mRNA vaccine for people living with systemic autoimmune rhumatic diseases without adequate humoral response post standard mRNA vaccination - Instituts de recherche en santé du Canada - Subvention de fonctionnement:Nouveaux besoins prioritaires en recherche sur la COVID-19, co-chercheur - 2021-12-01 au 2022-11-30
  • Role of antibodies in platelet response to SARS-CoV-2 and its variants - Instituts de recherche en santé du Canada - Subvention de fonctionnement : Possibilité de financement sur les nouveaux besoins prioritaires en recherche sur la COVID-19, co-chercheur - 2021-07-01 au 2022-06-30
  • Pathogenesis and immune escape potential of SARS-CoV-2 variants of concern - Instituts de recherche en santé du Canada - Subvention de fonctionnement : Possibilité de financement sur les nouveaux besoins prioritaires en recherche sur la COVID-19, chercheur principal - 2021-06-01 au 2022-05-31
  • COVID-19 trilogy: ARDS, inflammation and coagulopathy - Instituts de recherche en santé du Canada - Subvention de fonctionnement : Possibilité de financement pour une intervention de recherche rapide contre la COVID-19, chercheur principal - 2020-06-01 au 2021-05-31
  • Effect of cigarette smoke/e-cigarette vapor and SARS-CoV-2 infection on oral, nasal, and bronchial epithelial cell responses - Fonds de recherche du Québec - Santé - Réseaux thématiques de recherche, co-chercheur - 2020-04-01 au 2021-04-30
  • Understanding the pathogenesis of COVID-19 - Instituts de recherche en santé du Canada, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Subvention de fonctionnement : Possibilité de financement canadienne pour une intervention de recherche rapide contre la maladie à coronavirus 2019 (COVID-19), chercheur principal - 2020-03-01 au 2021-02-28

Publications

  • Mapping of human herpesvirus 6 immediate-early 2 protein transactivation domains., Flamand L, Gravel A, Tomoiu A, Virology, 2006, 10.1016/j.virol.2006.06.030
  • The Herpes Simplex Virus-1 genome contains multiple clusters of repeated G-quadruplex: Implications for the antiviral activity of a G-quadruplex ligand., Richter SN, Calistri A, Flamand L, Palù G, Biasolo MA, Perrone R, Nadai M, Artusi S, Antiviral research, 2015, 10.1016/j.antiviral.2015.03.016
  • Epstein-Barr virus infects and induces apoptosis in human neutrophils., Gosselin J, Beauchamp D, Gourde P, Flamand L, Larochelle B, Blood, 1998
  • Modulatory effects of Epstein-Barr, herpes simplex, and human herpes-6 viral infections and coinfections on cytokine synthesis. A comparative study., Menezes J, Gallo RC, Ablashi DV, Stefanescu I, Hiscott J, D'Addario M, Flamand L, Gosselin J, Journal of immunology (Baltimore, Md. : 1950), 1992
  • Influenza virus H1N1 activates platelets through FcγRIIA signaling and thrombin generation., Flamand L, Borgeat P, Lévesque T, Dubuc I, Cloutier N, Rousseau M, Paré G, Boilard E, Blood, 2014, 10.1182/blood-2013-07-515536
  • Interleukin-15 as an activator of natural killer cell-mediated antiviral response., Flamand L, Gallo RC, TomoIu A, Gosselin J, Blood, 1999
  • Phenotypic alterations and survival of monocytes following infection by human herpesvirus-6., Flamand L, Janelle ME, Archives of virology, 2006, 10.1007/s00705-005-0715-6
  • Frequency of chromosomally-integrated human herpesvirus 6 in children with acute lymphoblastic leukemia., Flamand L, Sinnett D, Gravel A, PloS one, 2013, 10.1371/journal.pone.0084322
  • Kaposi's sarcoma-associated herpesvirus K-bZIP protein is necessary for lytic viral gene expression, DNA replication, and virion production in primary effusion lymphoma cell lines., Flamand L, Lefort S, Journal of virology, 2009, 10.1128/jvi.01821-08
  • EBV suppresses prostaglandin E2 biosynthesis in human monocytes., Gosselin J, Borgeat P, Flamand L, Dumais N, Tremblay MJ, Bélanger C, Savard M, Journal of immunology (Baltimore, Md. : 1950), 2000, 10.4049/jimmunol.164.12.6467
  • Activation of the Epstein-Barr virus replicative cycle by human herpesvirus 6., Menezes J, Ablashi DV, Stefanescu I, Flamand L, Journal of virology, 1993, 10.1128/jvi.67.11.6768-6777.1993
  • Serological and virological investigation of the role of the herpesviruses EBV, CMV and HHV-6 in post-infective fatigue syndrome., Lloyd A, Ablashi D, Rawlinson W, Naing Z, Middeldorp J, Juwana H, Flamand L, Cameron B, Journal of medical virology, 2010, 10.1002/jmv.21873
  • Chromosomally integrated HHV-6: impact on virus, cell and organismal biology., Flamand L, Kaufer BB, Current opinion in virology, 2014, 10.1016/j.coviro.2014.09.010
  • Activation of monocyte cyclooxygenase-2 gene expression by human herpesvirus 6. Role for cyclic AMP-responsive element-binding protein and activator protein-1., Flamand L, Tremblay MJ, Gosselin J, Gravel A, Janelle ME, The Journal of biological chemistry, 2002, 10.1074/jbc.m203041200
  • Viral Proteins U41 and U70 of Human Herpesvirus 6A Are Dispensable for Telomere Integration., Kaufer BB, Flamand L, Weller SK, Sanyal A, Wallaschek N, Wight DJ, Viruses, 2018, 10.3390/v10110656
  • Platelet extracellular vesicles in COVID-19: Potential markers and makers., , Journal of leukocyte biology, 2021, 10.1002/jlb.3mir0221-100r
  • Extra domain A of fibronectin primes leukotriene biosynthesis and stimulates neutrophil migration through activation of Toll-like receptor 4., Borgeat P, Flamand L, Gravel A, Paré G, Picard S, Lévesque T, Lefebvre JS, Arthritis and rheumatism, 2011, 10.1002/art.30308
  • Antiviral Activity of the G-Quadruplex Ligand TMPyP4 against Herpes Simplex Virus-1, Sara Richter, Louis Flamand, Luigi XODO, Irene Zanin, Annalisa Ferino, Rosalba Perrone, Beatrice Tosoni, MATTEO NADAI, Emanuela Ruggiero, Sara Artusi, Viruses, 2021, 10.3390/v13020196
  • Classification of HHV-6A and HHV-6B as distinct viruses., Yoshikawa T, Luppi M, Jacobson S, Höllsberg P, Gompels UA, Gallo R, Frenkel N, Flamand L, DiLuca D, Dewhurst S, Clark DA, Alvarez-Lafuente R, Agut H, Ablashi D, Archives of virology, 2013, 10.1007/s00705-013-1902-5
  • HHV-6A/B Integration and the Pathogenesis Associated with the Reactivation of Chromosomally Integrated HHV-6A/B, , Viruses, 2017, 10.3390/v9070160
  • Chemokines and eicosanoids fuel the hyperinflammation within the lungs of patients with severe COVID-19., Flamand L, Boilard É, Flamand N, Laviolette M, Flamand O, Archambault AS, Dubuc I, Doré É, Zaid Y, The Journal of allergy and clinical immunology, 2021, 10.1016/j.jaci.2021.05.032
  • Infection of primary human monocytes by Epstein-Barr virus., Gosselin J, Flamand L, Gourde P, Tardif M, Bélanger C, Savard M, Journal of virology, 2000, 10.1128/jvi.74.6.2612-2619.2000
  • Impaired protein kinase C activation/translocation in Epstein-Barr virus-infected monocytes., Gosselin J, Flamand L, Savard M, Tardif M, The Journal of biological chemistry, 2002, 10.1074/jbc.m109036200
  • Functional interaction between human herpesvirus 6 immediate-early 2 protein and ubiquitin-conjugating enzyme 9 in the absence of sumoylation., Flamand L, Tanguay RM, Gravel A, Tomoiu A, Journal of virology, 2006, 10.1128/jvi.00375-06
  • Human herpesvirus 8 viral FLICE-inhibitory protein inhibits Fas-mediated apoptosis through binding and prevention of procaspase-8 maturation., Flamand L, Tremblay MJ, Gosselin J, Janelle ME, Tomoiu A, Gravel A, Bélanger C, Journal of human virology, 2001
  • Complete Genome Sequence of Early Passaged Human Herpesvirus 6A (GS Strain) Isolated from North America., Flamand L, Ablashi D, Gravel A, Genome announcements, 2013, 10.1128/genomea.00012-13
  • Inhibition of breast cancer cell proliferation through disturbance of the calcineurin/NFAT pathway by human herpesvirus 6B U54 tegument protein., Flamand L, Gravel A, Iampietro M, Journal of virology, 2014, 10.1128/jvi.02107-14
  • Herpesviruses and Chromosomal Integration, L. Flamand, G. Morissette, Journal of Virology, 2010, 10.1128/jvi.01169-10
  • The ND10 Complex Represses Lytic Human Herpesvirus 6A Replication and Promotes Silencing of the Viral Genome., Kaufer BB, Wight DJ, Flamand L, Glass M, Wallaschek N, Sanyal A, Viruses, 2018, 10.3390/v10080401
  • Inhibition of interleukin-2 gene expression by human herpesvirus 6B U54 tegument protein., Flamand L, Gravel A, Morissette G, Iampietro M, Journal of virology, 2014, 10.1128/jvi.02030-14
  • Mapping the Human Herpesvirus 6B transcriptome., Flamand L, Moorman N, Droit A, Fournier É, Sanders W, Gravel A, Journal of virology, 2021, 10.1128/jvi.01335-20
  • Urinary metabolites of leukotriene B4 in the human subject., Murphy RC, Flamand L, Gosselin J, Borgeat P, Berry KA, The Journal of biological chemistry, 2003, 10.1074/jbc.m300856200
  • Human herpesvirus-6 in patients with Crohn's disease., Van Kruiningen HJ, Colombel JF, Cartun R, Ablashi D, Flamand L, Gavrilov B, Sura R, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 2010, 10.1111/j.1600-0463.2010.02613.x
  • Increased tumorigenicity of cells carrying recombinant human herpesvirus 8., Flamand L, Gao SJ, Lefort S, Janelle ME, van Eyll O, Cloutier N, Archives of virology, 2007, 10.1007/s00705-007-1072-4
  • Generation and characterization of a monoclonal antibody specific for human herpesvirus 6 variant A immediate–early 2 protein, Louis Flamand, Jean Gosselin, Annie Gravel, Suzie Arsenault, Journal of Clinical Virology, 2003, 10.1016/s1386-6532(03)00050-7
  • Sequence analysis of transplacentally acquired human herpesvirus 6 DNA is consistent with transmission of a chromosomally integrated reactivated virus., Hall CB, Flamand L, Gravel A, The Journal of infectious diseases, 2013, 10.1093/infdis/jit060
  • Higher-Order Chromatin Structures of Chromosomally Integrated HHV-6A Predict Integration Sites., Frietze S, Kaufer B, Flamand L, Dest A, Richman A, Gerrard DL, Aimola G, Hasenohr E, Rodriguez P, Zimmerman C, Mariani M, Frontiers in cellular and infection microbiology, 2021, 10.3389/fcimb.2021.612656
  • The putative U94 integrase is dispensable for human herpesvirus 6 (HHV-6) chromosomal integration, Benedikt B. Kaufer, Louis Flamand, Annie Gravel, Nina Wallaschek, Journal of General Virology, 2016, 10.1099/jgv.0.000502
  • Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration., Boilard E, Rondina MT, Zhi H, Poirier G, Melki I, Tessandier N, Becker Y, Levesque T, Zufferey A, Mailhot B, Machlus KR, Marcoux G, Allaeys I, Cloutier N, Proceedings of the National Academy of Sciences of the United States of America, 2018, 10.1073/pnas.1720553115
  • Cell culture systems to study Human Herpesvirus 6A/B Chromosomal Integration, Louis Flamand, Benedikt B. Kaufer, Guy Boivin, Julie Carbonneau, Yasuko Mori, Keith R. Jerome, Ruth Hall-Sedlak, Vanessa Collin, Shella Gilbert-Girard, Nina Wallaschek, Isabelle Dubuc, Annie Gravel, Journal of Virology, 2017, 10.1128/jvi.00437-17
  • Chromatin Profiles of Chromosomally Integrated Human Herpesvirus-6A., Frietze S, Kaufer BB, Flamand L, Dubuc I, Gravel A, Morissette G, Wight DJ, Boyd JR, Gerrard DL, Signorelli SA, Mariani MP, Zimmermann C, Saviola AJ, Frontiers in microbiology, 2019, 10.3389/fmicb.2019.01408
  • Increased Serological Response Against Human Herpesvirus 6A Is Associated With Risk for Multiple Sclerosis., Fogdell-Hahn A, Alonso-Magdalena L, Hortlund M, Jons D, Michel A, Butt J, Brenner N, Khademi M, Stridh P, Lima Bomfim I, Biström M, Huang J, Gustafsson R, Engdahl E, Frontiers in immunology, 2019, 10.3389/fimmu.2019.02715
  • Pathogenesis from the reactivation of chromosomally integrated human herpesvirus type 6: facts rather than fiction., Flamand L, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2014, 10.1093/cid/ciu326
  • Chromosomal Integration by Human Herpesviruses 6A and 6B., Flamand L, Advances in experimental medicine and biology, 2018, 10.1007/978-981-10-7230-7_10
  • Modulation and recruitment of TRF2 at viral telomeres during human herpesvirus 6A/B infection, Flamand L, Lazzerini-Denchi E, Kaufer BB, Wight DJ, Collin V, Gravel A, Gilbert-Girard S, 2019, 10.1101/514075
  • CD4 promoter transactivation by human herpesvirus 6., Gallo RC, Reitz MS, Romerio F, Flamand L, Journal of virology, 1998, 10.1128/jvi.72.11.8797-8805.1998
  • Human Herpesvirus 7 induces CD4(+) T-cell death by two distinct mechanisms: necrotic lysis in productively infected cells and apoptosis in uninfected or nonproductively infected cells., Zauli G, Gallo RC, Capitani S, Robuffo I, Falcieri E, Gibellini D, Flamand L, Secchiero P, Blood, 1997
  • Inherited chromosomally integrated human herpesvirus 6 as a predisposing risk factor for the development of angina pectoris., Flamand L, Jerome KR, Sedlak RH, Morissette G, Dubuc I, Gravel A, Proceedings of the National Academy of Sciences of the United States of America, 2015, 10.1073/pnas.1502741112
  • High levels of eicosanoids and docosanoids in the lungs of intubated COVID-19 patients., Flamand N, Côté A, Tijani Y, El Hassani A, Fares H, Cheikh A, Amar Y, Flamand O, Martin C, Dubuc I, Doré É, Turcotte C, Rakotoarivelo V, Zaid Y, Archambault AS, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021, 10.1096/fj.202100540r
  • Cyclic AMP-responsive element-dependent activation of Epstein-Barr virus zebra promoter by human herpesvirus 6., Menezes J, Flamand L, Journal of virology, 1996, 10.1128/jvi.70.3.1784-1791.1996
  • Inherited chromosomally integrated HHV-6 demonstrates tissue-specific RNA expressionin vivothat correlates with increased antibody immune response, Greninger AL, Flamand L, Dubé M, Tardif J, Jerome KR, Tenenbaum D, Huang M, Xie H, Gravel A, Dubuc I, Peddu V, 2019, 10.1101/741025
  • Review, part 1: Human herpesvirus-6-basic biology, diagnostic testing, and antiviral efficacy, Dharam V. Ablashi, Peter G. Medveczky, Jesse H. Arbuckle, Anthony L. Komaroff, Louis Flamand, Journal of Medical Virology, 2010, 10.1002/jmv.21839
  • The role of the megakaryocyte in immunity has gone viral., Flamand L, Boilard E, Blood, 2019, 10.1182/blood-2019-02-900787
  • Association between the 2008-09 seasonal influenza vaccine and pandemic H1N1 illness during Spring-Summer 2009: four observational studies from Canada., Canadian SAVOIR Team, Willison DJ, Ouhoummane N, Sethi P, Gilca R, Dickinson JA, Rosella LC, Hottes TS, Boulianne N, Janjua NZ, Crowcroft NS, De Serres G, Skowronski DM, PLoS medicine, 2010, 10.1371/journal.pmed.1000258
  • Randomized clinical trial to evaluate the efficacy and safety of valganciclovir in a subset of patients with chronic fatigue syndrome., Desai M, Paik J, Kubo JT, Watt T, Merrihew LE, Flamand L, Lunn MR, Bhangoo M, Kogelnik AM, Montoya JG, Journal of medical virology, 2013, 10.1002/jmv.23713
  • Platelets can contain SARS-CoV-2 RNA and are hyperactivated in COVID-19, Boilard E, Cheikh A, Benouda A, Belefquih B, Lamiae B, Maher W, El Haj RB, Sadki K, Zaid N, Limami Y, Khalki L, Oudghiri M, Naya A, Allaeys I, Puhm F, Zaid Y, 2020, 10.1101/2020.06.23.20137596
  • Chromosomally Integrated HHV-6, Louis Flamand, Guillaume Morissette, Leonardo Potenza, Mario Luppi, Human Herpesviruses HHV-6A, HHV-6B & HHV-7, 2014, 10.1016/b978-0-444-62703-2.00015-x
  • Leukotriene B4 protects latently infected mice against murine cytomegalovirus reactivation following allogeneic transplantation., Flamand L, Borgeat P, Gosselin J, Journal of immunology (Baltimore, Md. : 1950), 2005, 10.4049/jimmunol.174.3.1587
  • SARS-CoV-2 deregulates the vascular and immune functions of brain pericytes via Spike protein., , Neurobiology of disease, 2021, 10.1016/j.nbd.2021.105561
  • Inherited Chromosomally Integrated Human Herpesvirus 6 Demonstrates Tissue-Specific RNA Expression In Vivo That Correlates with an Increased Antibody Immune Response., Greninger AL, Flamand L, Dubé MP, Tardif JC, Jerome KR, Tenenbaum D, Huang ML, Xie H, Gravel A, Dubuc I, Peddu V, Journal of virology, 2019, 10.1128/jvi.01418-19
  • Infection of peripheral blood mononuclear cells by herpes simplex and Epstein-Barr viruses. Differential induction of interleukin 6 and tumor necrosis factor-alpha., Menezes J, Hiscott J, D'Addario M, Flamand L, Gosselin J, The Journal of clinical investigation, 1992, 10.1172/jci115789
  • Variation in Human Herpesvirus 6B telomeric integration, excision and transmission between tissues and individuals, Royle N, Davison A, Flamand L, Tomaszewski M, Voors A, Samani N, Codd V, Romaine S, Martin D, Parker A, Nichols J, Suárez N, Neumann R, Veal C, Wood M, 2021, 10.1101/2021.06.07.447326
  • Platelet reactivity to thrombin differs between patients with COVID-19 and those with ARDS unrelated to COVID-19., Flamand L, Boilard E, Jalali F, Cheikh A, Morris AC, Chentoufi L, Elhamdani W, Puhm F, Guessous F, Zaid Y, Blood advances, 2021, 10.1182/bloodadvances.2020003513
  • Divergent susceptibilities of human herpesvirus 6 variants to type I interferon, Louis Flamand, Joanna Jaworska, Cytokine, 2009, 10.1016/j.cyto.2009.07.310
  • Immunosuppressive effect of human herpesvirus 6 on T-cell functions: suppression of interleukin-2 synthesis and cell proliferation., Menezes J, Ablashi D, Stefanescu I, Gosselin J, Flamand L, Blood, 1995
  • Human Herpesvirus 6 immediate-early 1 protein is a sumoylated nuclear phosphoprotein colocalizing with promyelocytic leukemia protein-associated nuclear bodies., Flamand L, Gosselin J, Gravel A, The Journal of biological chemistry, 2002, 10.1074/jbc.m200836200
  • Role for the shelterin protein TRF2 in human herpesvirus 6A/B chromosomal integration., Flamand L, Lazzerini-Denchi E, Kaufer BB, Wight DJ, Collin V, Gravel A, Gilbert-Girard S, PLoS pathogens, 2020, 10.1371/journal.ppat.1008496
  • Increased serological response against human herpesvirus 6A is associated with risk for multiple sclerosis, Fogdell-Hahn A, Alonso-Magdalena L, Hortlund M, Jons D, Michel A, Butt J, Brenner N, Khademi M, Stridh P, Bomfim IL, Biström M, Huang J, Gustafsson R, Engdahl E, 2019, 10.1101/737932
  • Chromosomally integrated human herpesvirus 6: questions and answers., Razonable RR, Lassner D, Kuehl U, Kamble RT, Hall CB, Gautheret-Dejean A, Flamand L, Descamps V, Caserta MT, Agut H, Ambros PF, Ablashi DV, Pellett PE, Reviews in medical virology, 2011, 10.1002/rmv.715
  • Inhibition of transcription of the beta interferon gene by the human herpesvirus 6 immediate-early 1 protein., Flamand L, Grandvaux N, Fink K, Gravel A, Jaworska J, Journal of virology, 2007, 10.1128/jvi.02443-06
  • Human herpesvirus-6 enhances natural killer cell cytotoxicity via IL-15., Menezes J, Stefanescu I, Flamand L, The Journal of clinical investigation, 1996, 10.1172/jci118557
  • Stabilization of telomere G-quadruplexes interferes with human herpesvirus 6A chromosomal integration, Louis Flamand, Benedikt B. Kaufer, Nina Wallaschek, Sara N. Richter, Sara Artusi, Annie Gravel, Shella Gilbert-Girard, Journal of Virology, 2017, 10.1128/jvi.00402-17
  • Summary of the 11th International Conference on Human Herpesviruses-6A, -6B, and -7., Flamand L, Zerr DM, Komaroff AL, Journal of medical virology, 2019, 10.1002/jmv.25576
  • Multiplex detection and quantitation of latent and lytic transcripts of human herpesvirus-8 using RNase Protection Assay., Flamand L, Gravel A, Cloutier N, Journal of virological methods, 2004, 10.1016/j.jviromet.2004.07.004
  • Epitope mapping of a monoclonal antibody specific for human herpesvirus 6 variant A immediate-early 2 protein., Flamand L, Tomoiu A, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2007, 10.1016/j.jcv.2006.12.025
  • Role of PML-Nuclear Bodies in Human Herpesvirus 6A and 6B Genome Integration, Flamand L, Kaufer BB, Gravel A, Collin V, 2018, 10.1101/413575
  • Characterization of human herpesvirus 6 variant B immediate-early 1 protein modifications by small ubiquitin-related modifiers., Flamand L, Gosselin J, Cloutier N, Dion V, Gravel A, The Journal of general virology, 2004, 10.1099/vir.0.19610-0
  • The Promyelocytic Leukemia Protein facilitates human herpesvirus 6B chromosomal integration, immediate-early 1 protein multiSUMOylation and its localization at telomeres., Flamand L, Kaufer BB, Gravel A, Collin V, PLoS pathogens, 2020, 10.1371/journal.ppat.1008683
  • Summary of the 9th international conference on human herpesviruses 6 and 7 (HHV-6A, HHV-6B, and HHV-7)., Pellett PE, Flamand L, Phan T, Komaroff AL, Journal of medical virology, 2016, 10.1002/jmv.24561
  • Human herpesvirus 7 induces the down-regulation of CD4 antigen in lymphoid T cells without affecting p56lck levels., Zauli G, Gallo RC, Capitani S, Marchisio M, Robuffo I, Flamand L, Gibellini D, Secchiero P, Journal of immunology (Baltimore, Md. : 1950), 1997
  • Amphipathic DNA polymers exhibit antiviral activity against systemic murine Cytomegalovirus infection., Vaillant A, Bernstein DI, Juteau JM, Flamand L, Cummins J, Sewell AP, Bravo FJ, Cardin RD, Virology journal, 2009, 10.1186/1743-422x-6-214
  • 2-Arachidonoyl-glycerol- and arachidonic acid-stimulated neutrophils release antimicrobial effectors against E. coli, S. aureus, HSV-1, and RSV., Flamand N, Grandvaux N, Flamand L, Provost V, Bouchard L, Poirier S, Larose MC, Guan X, Turcotte C, Chouinard F, Journal of leukocyte biology, 2012, 10.1189/jlb.0412200
  • Detection of Human Herpesvirus 6B (HHV-6B) Reactivation in Hematopoietic Cell Transplant Recipients with Inherited Chromosomally Integrated HHV-6A by Droplet Digital PCR., Jerome KR, Boeckh M, Zerr DM, Flamand L, Huang ML, Cook L, Levin G, Cho M, Nguyen T, Hill JA, Sedlak RH, Journal of clinical microbiology, 2016, 10.1128/jcm.03275-15
  • Synergistic activation of interferon-beta gene transcription by the viral FLICE inhibitory protein of Kaposi's sarcoma-associated herpesvirus and type I IFN activators., Flamand L, Grandvaux N, Cloutier N, European journal of immunology, 2007, 10.1002/eji.200737181
  • rs73185306 C/T Is Not a Predisposing Risk Factor for Inherited Chromosomally Integrated Human Herpesvirus 6A/B., Flamand L, Dubé MP, Tardif JC, Busseuil D, Provost S, Feroz Zada Y, Dubuc I, Gravel A, Mouammine A, The Journal of infectious diseases, 2020, 10.1093/infdis/jiz527
  • Multicenter Comparison of PCR Assays for Detection of Human Herpesvirus 6 DNA in Serum, Ablashi D, Yoshikawa T, Tang Y, Kohn D, Malnati M, Jacobson S, Alvarez-Lafuente R, Boutolleau D, Gravel A, Flamand L, Journal of clinical microbiology, 2009
  • Human herpesvirus 6 induces interleukin-1 beta and tumor necrosis factor alpha, but not interleukin-6, in peripheral blood mononuclear cell cultures., Menezes J, Gallo RC, Ablashi DV, Hiscott J, D'Addario M, Gosselin J, Flamand L, Journal of virology, 1991, 10.1128/jvi.65.9.5105-5110.1991
  • Repression of interferon-α stimulated genes expression by Kaposi's sarcoma-associated herpesvirus K-bZIP protein., Flamand L, Gravel A, Lefort S, Virology, 2010, 10.1016/j.virol.2010.07.027
  • The immediate early protein 1 of the human herpesvirus 6B counteracts NBS1 and prevents homologous recombination repair pathways, Fradet-Turcotte A, Flamand L, Gravel A, Dessapt J, Gaudreau-Lavoie É, Tremblay V, Biquand É, Collin V, 2021, 10.1101/2021.07.31.454588
  • Inherited Chromosomally Integrated Human Herpesvirus 6 and Breast Cancer, Louis Flamand, John J. Spinelli, Héctor A. Velásquez-García, Jacques Simard, Kristan J. Aronson, Angela Brooks-Wilson, Isabelle Dubuc, Annie Gravel, Cancer Epidemiology Biomarkers & Prevention, 2016, 10.1158/1055-9965.epi-16-0735
  • Characterization of human herpesvirus 6A/B U94 as ATPase, helicase, exonuclease and DNA-binding proteins, Louis Flamand, Benedikt B. Kaufer, Guillaume Morissette, Shella Gilbert-Girard, Vanessa Collin, Nina Wallaschek, Isabelle Dubuc, Annie Gravel, Frédéric Trempe, Nucleic Acids Research, 2015, 10.1093/nar/gkv503
  • Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen inhibits interferon (IFN) beta expression by competing with IFN regulatory factor-3 for binding to IFNB promoter., Flamand L, Cloutier N, The Journal of biological chemistry, 2010, 10.1074/jbc.m109.018838
  • Inhibition of tumor necrosis factor-alpha transcription by Epstein-Barr virus., Oth D, Lamoureux G, Flamand L, Hiscott J, D'Addario M, Menezes J, Gosselin J, European journal of immunology, 1991, 10.1002/eji.1830210130
  • Association of human herpes virus 6 (HHV-6) with multiple sclerosis: increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA., Jacobson S, Patnaik M, Lin HC, McFarland HF, Maloni HW, Brennan MB, Calabresi PA, Flamand L, Secchiero P, Salem N, Berti R, Soldan SS, Nature medicine, 1997, 10.1038/nm1297-1394
  • Activation of CD8+ T lymphocytes through the T cell receptor turns on CD4 gene expression: implications for HIV pathogenesis., Gallo RC, Margolis DM, Colombini-Hatch S, Lusso P, Crowley RW, Flamand L, Proceedings of the National Academy of Sciences of the United States of America, 1998, 10.1073/pnas.95.6.3111
  • Effects of a urinary factor from women in early pregnancy on HIV-1, SIV and associated disease., Gallo RC, Birken S, Hermans P, Gill P, Flamand L, Hung CL, Blattner WA, Bryant JL, Lunardi-Iskandar Y, Nature medicine, 1998, 10.1038/nm0498-428
  • Variation in human herpesvirus 6B telomeric integration, excision, and transmission between tissues and individuals., Royle NJ, Davison AJ, Flamand L, Tomaszewski M, Voors AA, Samani NJ, Codd V, Romaine SP, Martin D, Parker AJ, Nichols J, Suárez NM, Neumann R, Veal CD, Wood ML, eLife, 2021, 10.7554/elife.70452
  • [Role of liposomes in the presentation of HIV envelope glycoprotein and the immune response in mice], Montagnier L, Tremblay C, Lachapelle L, Oth D, Flamand L, Chagnon M, Thibodeau L, Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie, 1989
  • Contagious period for pandemic (H1N1) 2009., Boivin G, Charest H, Couillard M, Bourgault A, Li Y, Carbonneau J, Boulianne N, Flamand L, Skowronski D, Quach C, Hamelin ME, Rouleau I, De Serres G, Emerging infectious diseases, 2010, 10.3201/eid1605.091894
  • Multicenter comparison of PCR assays for detection of human herpesvirus 6 DNA in serum., Ablashi D, Yoshikawa T, Tang YW, Kohn D, Malnati MS, Jacobson S, Alvarez-Lafuente R, Boutolleau D, Gravel A, Flamand L, Journal of clinical microbiology, 2008, 10.1128/jcm.00370-08
  • The Telomeric Repeats of Human Herpesvirus 6A (HHV-6A) Are Required for Efficient Virus Integration, Benedikt B. Kaufer, Louis Flamand, Yasuko Mori, Annie Gravel, Fabian Pirzer, Anirban Sanyal, Nina Wallaschek, PLOS Pathogens, 2016, 10.1371/journal.ppat.1005666
  • SARS-CoV-2 Nsp2 Contributes to Inflammation by Activating NF-κB, Louis Flamand, Éric Boilard, Isabelle Allaeys, Annie Gravel, Isabelle Dubuc, Leslie Gudimard, Émile Lacasse, Viruses, 2023, 10.3390/v15020334
  • Absence of human herpesvirus 8 DNA sequences in neoplastic Kaposi's sarcoma cell lines., Gallo RC, Lunardi-Iskandar Y, Bryant JL, Zeman RA, Flamand L, Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association, 1996, 10.1097/00042560-199610010-00011
  • Identification of functional microRNAs released through asymmetrical processing of HIV-1 TAR element., Provost P, Tremblay MJ, Flamand L, Janelle ME, Barat C, Landry P, Plante I, Ouellet DL, Nucleic acids research, 2008, 10.1093/nar/gkn076
  • Characterization of the immediate-early 2 protein of human herpesvirus 6, a promiscuous transcriptional activator., Flamand L, Gosselin J, Cloutier N, Tomoiu A, Gravel A, Virology, 2003, 10.1016/s0042-6822(03)00007-2
  • Release of anti-HIV mediators after administration of leukotriene B4 to humans., Gosselin J, Lalonde R, Borgeat P, Flamand L, The Journal of infectious diseases, 2004, 10.1086/386374
  • Normal human primary CD4+ T lymphocytes synthesize and release functional osteoprotegerin in vitro., Poubelle PE, Flamand L, Marceau AA, Chakravarti A, Laboratory investigation; a journal of technical methods and pathology, 2007, 10.1038/labinvest.3700701
  • Platelets Can Associate with SARS-Cov-2 RNA and Are Hyperactivated in COVID-19., Boilard E, Benouda A, Belefquih B, Belayachi L, Mahir W, Ben El Haj R, Sadki K, Zaid N, Limami Y, Khalki L, Oudghiri M, Naya A, Allaeys I, Puhm F, Zaid Y, Circulation research, 2020, 10.1161/circresaha.120.317703
  • Divergent susceptibilities of human herpesvirus 6 variants to type I interferons., Flamand L, Gravel A, Jaworska J, Proceedings of the National Academy of Sciences of the United States of America, 2010, 10.1073/pnas.0909951107
  • Leukotriene B4 triggers the in vitro and in vivo release of potent antimicrobial agents., Borgeat P, Tremblay MJ, Flamand L, Journal of immunology (Baltimore, Md. : 1950), 2007, 10.4049/jimmunol.178.12.8036
  • LTB4 increases nasal neutrophil activity and conditions neutrophils to exert antiviral effects., Greiff L, Johnston S, Flamand L, Borgeat P, Andersson M, Widegren H, Respiratory medicine, 2011, 10.1016/j.rmed.2010.12.021
  • Epstein-Barr virus primes human polymorphonuclear leucocytes for the biosynthesis of leukotriene B4., Borgeat P, Flamand L, Tardif M, Savard M, Gosselin J, Clinical and experimental immunology, 2001, 10.1046/j.1365-2249.2001.01687.x
  • Lipid storm within the lungs of severe COVID-19 patients: Extensive levels of cyclooxygenase and lipoxygenase-derived inflammatory metabolites, Flamand N, Boilard É, Laviolette M, Tijani Y, El Hassani A, Fares H, Cheikh A, Amar Y, Martin C, Dubuc I, Doré É, Rakotoarivelo V, Zaid Y, Archambault A, 2020, 10.1101/2020.12.04.20242115
  • Human herpesvirus 6B immediate-early I protein contains functional HLA-A*02, HLA-A*03, and HLA-B*07 class I restricted CD8(+) T-cell epitopes., Flamand L, O'Reilly RJ, Hasan A, Rousseau M, Dubuc I, Gravel A, Morissette G, Iampietro M, European journal of immunology, 2014, 10.1002/eji.201444931
  • Binding of Kaposi's sarcoma-associated herpesvirus K-bZIP to interferon-responsive factor 3 elements modulates antiviral gene expression., Flamand L, Grandvaux N, Soucy-Faulkner A, Lefort S, Journal of virology, 2007, 10.1128/jvi.00183-07
  • [Human herpesviruses HHV-6 and chromosomal integration: pathological and medical associated consequences]., Flamand L, Gravel A, Morissette G, Trempe F, Virologie (Montrouge, France), 2011, 10.1684/vir.2011.0428

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Emile Lacasse - Doctorat - En cours
  • Joannie Leclerc - Maîtrise avec mémoire - En cours
  • Ana Claudia Dos Santos Pereira Andrad - Post-doctorat - En cours
  • Noémie Rochon - Maîtrise avec mémoire - En cours
  • Léa Lambert - Maîtrise avec mémoire - En cours
  • Shella Gilbert-Girard - Maîtrise avec mémoire - 2016/09
  • Vanessa Collin - Maîtrise avec mémoire - 2018/09
  • Sabrina Gentil - Maîtrise avec mémoire - 2023/09

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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