Yves De Koninck

Professeur titulaire

Directeur(trice), Centre de recherche CERVO

yves.dekoninck@neuro.ulaval.ca

Département de psychiatrie et de neurosciences

Centre de recherche CERVO

Centre d'optique, photonique et laser

Centre thématique de recherche en neurosciences

Centre de recherche CERVO

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Contribution à la recherche

Projets de recherche

Unraveling sensory coding dysfunctions that underlie chronic pain - Instituts de recherche en santé du Canada - Subventions Fondation, chercheur principal - 2018-07-01 au 2025-06-30
Tools to decipher neuronal signalling and computation - Conseil de recherches en sciences naturelles et génie Canada, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2020-04-01 au 2025-03-31
Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
The Canadian Brain Research Strategy (International Brain Initiative Canadian Secretariat) - Instituts de recherche en santé du Canada - Subventions Catalyseur de réseaux, chercheur principal - 2020-04-01 au 2025-03-31
A prospective translational model of the therapeutic potential of cannabidiol in reducing acute pain symptoms and opioid usage following traumatic injury - Instituts de recherche en santé du Canada - Subvention d'équipe:Recherche sur le cannabis dans des domaines prioritaires, Université de Montréal, co-chercheur - 2020-01-01 au 2024-12-31
Smart, adaptative, and autonomous sensing - Université Laval - Fonds internes, Sentinelle Nord (usage exclusif VRRCI), Conseil de recherches en sciences naturelles et génie Canada, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Programme de formation orientée vers la nouveauté, la collaboration et l'expérience en recherche (FONCER), co-chercheur - 2017-04-01 au 2024-03-31
Muscarinic receptor antagonisrn as a novel mechanism for sensory nerve repair - Instituts de recherche en santé du Canada - Subvention Projet, University of Manitoba, co-chercheur - 2019-04-01 au 2024-03-31
Centre d'optique photonique et laser (COPL) - Université de Sherbrooke, École polytechnique de Montréal, Université McGill, Université Concordia, Fonds de recherche du Québec - Nature et technologies, École de technologie supérieure, Université Laval - Fonds internes - Regroupements stratégiques NT, co-chercheur - 2017-04-01 au 2024-03-31
Canadian Optogenetics and Vectorology Foundry - Université d'Ottawa, The Governos of the University of Calgary, Brain Canada Foundation, The Royal Institution for the advancement of learning, Djavad Mowafaghian Centre for Brain Health, Fondation CERVO, chercheur principal - 2020-10-01 au 2024-03-31
Novel technology for quality control of viral vector particles - Conseil de recherches en sciences naturelles et génie Canada - Subventions Missions d’Alliance, chercheur principal - 2022-03-01 au 2024-02-28
Chaire de recherche sur le cerveau et la douleur - Fondation de l'Université Laval - Chaires de recherche sans organismes subventionnaires, chercheur principal - 2013-12-10 au 2023-12-10
Comorbidity of cHronic Pain and mood disorders: breaking the vicious cYcle HaPpY - Centre national de la recherche scientifique (France) - Marie-Sklodowska-Curie action- Initiative Training Networks (ITN), chercheur principal - 2021-07-01 au 2023-06-30
Chloride dysregulation and neuropathic pain: Linking molecular mechanisms with altered pain processing via identification of cellular and circuit level changes - Instituts de recherche en santé du Canada - Subvention Projet, University of Toronto, co-chercheur - 2017-04-01 au 2023-03-31
Mechanisms of itch - from endosomal signalling to neural circuits - Australian Research Council, Monash University, co-chercheur - 2018-04-01 au 2023-03-31
Smart neuroscience platform enhancement and pilot data on using KCC2 as a new target for Alzheimer's disease - Weston Brain institute - Transformational Research, co-chercheur - 2020-01-01 au 2023-03-31
Mechanisms of itch - from endosomal signalling to neural circuits - Australian Research Council, Monash University, co-chercheur - 2019-04-01 au 2023-03-31
Chaire de recherche du Canada en douleur chronique et troubles cérébraux associés - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2016-01-01 au 2022-12-31
Modulation de l'activité des réseaux de la corne dorsale de la moelle épinière par des systèmes en boucles fermées - MITACS Inc. - Bourse de recherche Mitacs Globalink, chercheur principal - 2022-03-13 au 2022-09-12
Sentinelle Nord - Secrétariat des programmes interorganismes à l’intention des établissements - Fonds d'excellence en recherche Apogée Canada, co-chercheur - 2015-09-01 au 2022-09-01
Budget de recherche statutaire des directeurs scientifiques de Sentinelle Nord - Secrétariat des programmes interorganismes à l’intention des établissements - Fonds d'excellence en recherche Apogée Canada, chercheur principal - 2017-04-01 au 2022-08-31
Programme VISION - Fonds de recherche du Québec - Santé - Tremplin, co-chercheur - 2021-11-01 au 2022-04-30
Union Neurosciences et Intelligence Artificielle Québec - Université McGill, Fonds de recherche du Québec - Nature et technologies, Université Laval - Fonds internes - Regroupements stratégiques NT, Université de Montréal, co-chercheur - 2019-04-01 au 2022-03-31
Genetic analysis of spinothalamic neuron function in nociception - Instituts de recherche en santé du Canada - Subvention Projet, Université de Montréal, co-chercheur - 2017-04-01 au 2022-03-31
Fonds institutionnel d'exploitation des infrastructures pour l'IUSMQ (CERVO) - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), chercheur principal - 2013-04-01 au 2022-03-31
Prix Brockhouse du Canada pour la recherche interdisciplinaire en sciences et en génie - Conseil de recherches en sciences naturelles et génie Canada - Prix Brockhouse du Canada, chercheur principal - 2018-04-01 au 2021-03-31
Neurophotonics Initiative, phase II - CHU de Québec – Université Laval – CHUL, Ministère de la Santé et des Services sociaux, CIUSSS - CN - CERVO, Université Laval - Fonds internes, Fondation Canadienne pour l'innovation (La), Ministère de l'Enseignement supérieur, de la Recherche, de la Science - Fonds d'innovation (FI), chercheur principal - 2015-10-01 au 2021-03-30
Canadian Open Neuroscience Platform - Brain Canada Foundation, La Fondation Neuro Canada / Brain Canada, McGill University, co-chercheur - 2017-11-01 au 2020-10-31
Redefining pain and suffering; from biophysical to socio-cultural principles - Université Laval - Fonds internes - BDR - Contributions, chercheur principal - 2019-12-20 au 2020-07-31
Microglia contribute to on-going pain caused by TBI - United States Army - Neurosensory and Rehabilitation Research Award, University of California - Irvine, co-chercheur - 2015-09-30 au 2020-06-30

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Publications

Anisotropic light scattering from myelinated axons in the spinal cord, Depaoli, D., Gasecka, A., Bahdine, M., Deschenes, J.M., Goetz, L., Perez-Sanchez, J., Bonin, R.P., De Koninck, Y., Parent, M., Côté, D.C., Neurophotonics, 2020, 10.1117/1.NPh.7.1.015011
Cortical interneuron-mediated inhibition delays the onset of amyotrophic lateral sclerosis, Khademullah, C. Sahara, Aqrabawi, Afif J., Place, Kara M., Dargaei, Zahra, Liang, Xinyi, Pressey, Jessica C., Bedard, Simon, Yang, Jy Wei, Garand, Danielle, Keramidis, Iason, Gasecka, Alicja, Cote, Daniel, De Koninck, Yves, Keith, Julia, Zinman, Lorne, Robertson, Janice, Kim, Jun Chul, Woodin, Melanie A., Brain, 2020, 10.1093/BRAIN/AWAA034
Developmental Potential and Plasticity of Olfactory Epithelium Stem Cells Revealed by Heterotopic Grafting in the Adult Brain, Li, Qian, Siri, Tiziano, Bressan, Cedric, de Koninck, Yves, Saghatelyan, Armen, Stem Cell Reports, 2020, 10.1016/J.STEMCR.2020.03.008
Enhancing neuronal chloride extrusion rescues alpha 2/alpha 3 GABA(A)-mediated analgesia in neuropathic pain, , Nature Communications, 2020
International Brain Initiative: An Innovative Framework for Coordinated Global Brain Research Efforts, Adams, Amy, Bjaalie, Jan G., Deshler, James O., De Koninck, Yves, Egan, Gary, Illes, Judy, Jeong, Sung-Jin, Montojo, Caroline, Okabe, Shigeo, Pei, Gang, Richards, Linda J., Suh, Pann-Ghill, Zhang, Xu, Zheng, Jialin, Albin, Stephanie, Amunts, Katrin, Asakawa, Tasia, Bernard, Amy, Chakli, Khaled, Ebell, Christoph J., Hale, Melina, Hausser, Michael, Lanyon, Linda, Li, Yan, Magistretti, Pierre, McMahon, Agnes, Okano, Hideyuki, Ohtsuka, Toshihisa, Pouget, Alexandre, Rommelfanger, Karen S., Reindorp, Jason, Sajda, Paul, Scobie, Kimberly N., Tanaka, Keiji, Thiels, Edda, Valdes-Sosa, Pedro A., Welchman, Andrew E., White, Samantha, Wilson, Gary, Yuste, Rafael, Neuron, 2020, 10.1016/J.NEURON.2020.01.002
Sortilin gates neurotensin and BDNF signaling to control peripheral neuropathic pain., , Science advances, 2019, 10.1126/sciadv.aav9946
Loss of STEP61 couples disinhibition to N-methyl-d-aspartate receptor potentiation in rodent and human spinal pain processing., , Brain : a journal of neurology, 2019, 10.1093/brain/awz105
A Neuroethics Backbone for the Evolving Canadian Brain Research Strategy., , Neuron, 2019, 10.1016/j.neuron.2018.12.021
A Wireless Electro-Optic Headstage With a 0.13-mu m CMOS Custom Integrated DWT Neural Signal Decoder for Closed-Loop Optogenetics, Gagnon-Turcotte, Gabriel, Keramidis, Iason, Ethier, Christian, De Koninck, Yves, Gosselin, Benoit, IEEE Transactions on Biomedical Circuits and Systems, 2019, 10.1109/TBCAS.2019.2930498
Chloride Dysregulation through Downregulation of KCC2 Mediates Neuropathic Pain in Both Sexes, Mapplebeck, Josiane C. S., Lorenzo, Louis-Etienne, Lee, Kwan Yeop, Gauthier, Cedric, Muley, Milind M., De Koninck, Yves, Prescott, Steven A., Salter, Michael W., Cell Reports, 2019, 10.1016/J.CELREP.2019.06.059
High-DR CMOS Fluorescence Biosensor With Extended Counting ADC and Noise Cancellation, Khiarak, Mehdi Noormohammadi, Martel, Sylvain, De Koninck, Yves, Gosselin, Benoit, IEEE Transactions on Circuits and Systems I: Regular Papers, 2019, 10.1109/TCSI.2019.2895652
Resolution enhancement in laser scanning microscopy with deconvolution switching laser modes (D-SLAM)., , Optics express, 2018, 10.1364/oe.26.024881
Transition to chronic pain: opportunities for novel therapeutics, Theodore J. Price, Allan I. Basbaum, Jacqueline Bresnahan, Jan F. Chambers, Yves De Koninck, Robert R. Edwards, Ru-Rong Ji, Joel Katz, Annemieke Kavelaars, Jon D. Levine, Linda Porter, Neil Schechter, Kathleen A. Sluka, Gregory W. Terman, Tor D. Wager, Tony L. Yaksh, Robert H. Dworkin, Nature Reviews Neuroscience, 2018, 10.1038/s41583-018-0012-5
A Wireless Fiber Photometry System Based on a High-Precision CMOS Biosensor With Embedded Continuous-Time Modulation., , IEEE transactions on biomedical circuits and systems, 2018, 10.1109/tbcas.2018.2817200
Amiloride modulation of carbon dioxide hypersensitivity and thermal nociceptive hypersensitivity induced by interference with early maternal environment., , Journal of psychopharmacology (Oxford, England), 2018, 10.1177/0269881118784872
Sensory Afferents Use Different Coding Strategies for Heat and Cold., , Cell reports, 2018, 10.1016/j.celrep.2018.04.065
A Low-Power Current-Reuse Analog Front-End for High-Density Neural Recording Implants., , IEEE transactions on biomedical circuits and systems, 2018, 10.1109/tbcas.2018.2805278
A 0.13-mu m CMOS SoC for Simultaneous Multichannel Optogenetics and Neural Recording, Gabriel Gagnon-Turcotte, Mehdi Noormohammadi Khiarak, Christian Ethier, Yves De Koninck, Benoit Gosselin, IEEE Journal of Solid-State Circuits, 2018, 10.1109/JSSC.2018.2865474
Enhancing KCC2 function counteracts morphine-induced hyperalgesia, Francesco Ferrini, Louis-Etienne Lorenzo, Antoine G. Godin, Miorie Le Quang, Yves De Koninck, Scientific Reports, 2017, 10.1038/s41598-017-04209-3
Reply to The small molecule CLP257 does not modify activity of the K+–Cl− co-transporter KCC2 but does potentiate GABAA receptor activity, Martin Gagnon, Marc J Bergeron, Jimena Perez-Sanchez, Isabel Plasencia-Fernández, Louis-Etienne Lorenzo, Antoine G Godin, Annie Castonguay, Robert P Bonin, Yves De Koninck, Nature Medicine, 2017, 10.1038/nm.4449
Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition., , eLife, 2017, 10.7554/eLife.28270
Spinal microglia are required for long-term maintenance of neuropathic pain., , Pain, 2017, 10.1097/j.pain.0000000000000982
Transgenic autoinhibition of p21-activated kinase exacerbates synaptic impairments and fronto-dependent behavioral deficits in an animal model of Alzheimer's disease., , Aging, 2017, 10.18632/aging.101239
Development and Implementation of a Registry of Patients Attending Multidisciplinary Pain Treatment Clinics: The Quebec Pain Registry., , Pain research & management, 2017, 10.1155/2017/8123812
Resolution enhancement in confocal microscopy using Bessel-Gauss beams., , Optics express, 2017, 10.1364/oe.25.002162
Blocking microglial pannexin-1 channels alleviates morphine withdrawal in rodents., , Nature medicine, 2017, 10.1038/nm.4281
Striatal Neurons Expressing D1 and D2 Receptors are Morphologically Distinct and Differently Affected by Dopamine Denervation in Mice., , Scientific reports, 2017, 10.1038/srep41432
Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition, Mahadevan, V., Khademullah, C.S., Dargaei, Z., Chevrier, J., Uvarov, P., Kwan, J., Bagshaw, R.D., Pawson, T., Emili, A., De Koninck, Y., Anggono, V., Airaksinen, M., Woodin, M.A., eLife, 2017, 10.7554/eLife.28270.001
α5GABAA Receptors Mediate Tonic Inhibition in the Spinal Cord Dorsal Horn and Contribute to the Resolution Of Hyperalgesia., , Journal of neuroscience research, 2016, 10.1002/jnr.23981
Probing pain pathways with light., , Neuroscience, 2016, 10.1016/j.neuroscience.2016.09.035
Live single-cell laser tag, Loïc Binan, Javier Mazzaferri, Karine Choquet, Louis-Etienne Lorenzo, Yu Chang Wang, El Bachir Affar, Yves De Koninck, Jiannis Ragoussis, Claudia L. Kleinman, Santiago Costantino, Nature Communications, 2016, 10.1038/ncomms11636
Coxsackievirus Adenovirus Receptor Loss Impairs Adult Neurogenesis, Synapse Content, and Hippocampus Plasticity., , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016, 10.1523/jneurosci.0132-16.2016
An E3-ligase-based method for ablating inhibitory synapses, Garrett G Gross, Christoph Straub, Jimena Perez-Sanchez, William P Dempsey, Jason A Junge, Richard W Roberts, Le A Trinh, Scott E Fraser, Yves De Koninck, Paul De Koninck, Bernardo L Sabatini, Don B Arnold, Nature Methods, 2016, 10.1038/nmeth.3894
A Wireless Headstage for Combined Optogenetics and Multichannel Electrophysiological Recording., , IEEE transactions on biomedical circuits and systems, 2016, 10.1109/tbcas.2016.2547864
Chloride Regulation: A Dynamic Equilibrium Crucial for Synaptic Inhibition, Doyon, Nicolas, Vinay, Laurent, Prescott, Steven A., De Koninck, Yves, Neuron, 2016, 10.1016/j.neuron.2016.02.030
Dynamics of spinal microglia repopulation following an acute depletion, Yao, Yao, Echeverry, Stefania, Shi, Xiang Qun, Yang, Mu, Yang, Qiu Zi, Wang, Guan Yun Frances, Chambon, Julien, Wu, Yi Chen, Fu, Kai Yuan, De Koninck, Yves, Zhang, Ji, Scientific Reports, 2016, 10.1038/srep22839
Endocannabinoid signaling enhances visual responses through modulation of intracellular chloride levels in retinal ganglion cells, Miraucourt, L. S., Tsui, J., Gobert, D., Desjardins, J. F., Schohl, A., Sild, M., Spratt, P., Castonguay, A., De Koninck, Y., Marsh-Armstrong, N., Wiseman, P. W., Ruthazer, E. S., eLife, 2016, 10.7554/ELIFE.15932
Epidural optogenetics for controlled analgesia, Bonin, Robert P., Wang, Feng, Desrochers-Couture, Mireille, Gasecka, Alicja, Boulanger, Marie-Eve, Cote, Daniel C., De Koninck, Yves, Molecular Pain, 2016
Epidural optogenetics for controlled analgesia, Robert P Bonin, Feng Wang, Mireille Desrochers-Couture, Alicja Ga¸secka, Marie-Eve Boulanger, Daniel C Côté, Yves De Koninck, Molecular Pain, 2016, 10.1177/1744806916629051
Mild KCC2 Hypofunction Causes Inconspicuous Chloride Dysregulation that Degrades Neural Coding, Doyon, Nicolas, Prescott, Steven A., De Koninck, Yves, Frontiers in Cellular Neuroscience, 2016, 10.3389/fncel.2015.00516
Neuroimmune Regulation of GABAergic Neurons Within the Ventral Tegmental Area During Withdrawal from Chronic Morphine, Taylor, Anna M. W., Castonguay, Annie, Ghogha, Atefeh, Vayssiere, Pia, Pradhan, Amynah A. A., Xue, Lihua, Mehrabani, Sadaf, Wu, Juli, Levitt, Pat, Olmstead, Mary C., De Koninck, Yves, Evans, Christopher J., Cahill, Catherine M., Neuropsychopharmacology, 2016, 10.1038/npp.2015.221
Rapid Mechanically Controlled Rewiring of Neuronal Circuits, Magdesian, Margaret H., Lopez-Ayon, G. Monserratt, Mori, Megumi, Boudreau, Dominic, Goulet-Hanssens, Alexis, Sanz, Ricardo, Miyahara, Yoichi, Barrett, Christopher J., Fournier, Alyson E., De Koninck, Yves, Gruetter, Peter, Journal of Neuroscience, 2016, 10.1523/JNEUROSCI.1667-15.2016
A Wireless Optogenetic Headstage with Multichannel Electrophysiological Recording Capability, Gagnon-Turcotte, Gabriel, Kisomi, Alireza Avakh, Ameli, Reza, Camaro, Charles-Olivier Dufresne, LeChasseur, Yoan, Neron, Jean-Luc, Bareil, Paul Brule, Fortier, Paul, Bories, Cyril, de Koninck, Yves, Gosselin, Benoit, Sensors, 2015, 10.3390/s150922776
Allosteric modulation of metabotropic glutamate receptors by chloride ions, Tora, Amelie S., Rovira, Xavier, Dione, Ibrahima, Bertrand, Hugues-Olivier, Brabet, Isabelle, De Koninck, Yves, Doyon, Nicolas, Pin, Jean-Philippe, Acher, Francine, Goudet, Cyril, Faseb Journal, 2015, 10.1096/fj.14-269746
Central neuroglial interactions in the pathophysiology of neuropathic pain, Zhang, J., De Koninck, Y., Functional Pain Syndromes: Presentation and Pathophysiology, 2015
Engagement of the GABA to KCC2 Signaling Pathway Contributes to the Analgesic Effects of A(3)AR Agonists in Neuropathic Pain, Ford, Amanda, Castonguay, Annie, Cottet, Martin, Little, Joshua W., Chen, Zhoumou, Symons-Liguori, Ashley M., Doyle, Timothy, Egan, Terrance M., Vanderah, Todd W., De Konnick, Yves, Tosh, Dilip K., Jacobson, Kenneth A., Salvemini, Daniela, Journal of Neuroscience, 2015, 10.1523/JNEUROSCI.4495-14.2015
Maintaining polarization in polarimetric multiphoton microscopy, Belanger, Erik, Turcotte, Raphael, Daradich, Amy, Sadetsky, Gregory, Gravel, Pierre, Bachand, Karine, De Koninck, Yves, Cote, Daniel C., Journal of Biophotonics, 2015, 10.1002/jbio.201400116
Microglia Disrupt Mesolimbic Reward Circuitry in Chronic Pain, Taylor, Anna M. W., Castonguay, Annie, Taylor, Alison J., Murphy, Niall P., Ghogha, Atefeh, Cook, Christopher, Xue, Lihua, Olmstead, Mary C., De Koninck, Yves, Evans, Christopher J., Cahill, Catherine M., Journal of Neuroscience, 2015, 10.1523/JNEUROSCI.4036-14.2015
Optrodes for combined optogenetics and electrophysiology in live animals., Dufour, Suzie, De Koninck, Yves, Neurophotonics, 2015, 10.1117/1.NPh.2.3.031205
Reconsolidation and the regulation of plasticity: moving beyond memory, Bonin, Robert P., De Koninck, Yves, Trends in Neurosciences, 2015, 10.1016/j.tins.2015.04.007
Spatial Intensity Distribution Analysis Reveals Abnormal Oligomerization of Proteins in Single Cells, Godin, Antoine G., Rappaz, Benjamin, Potvin-Trottier, Laurent, Kennedy, Timothy E., De Koninck, Yves, Wisemant, Paul W., Biophysical Journal, 2015, 10.1016/j.bpj.2015.06.068
Translational control of nociception via 4E-binding protein 1., Khoutorsky, Arkady, Bonin, Robert P, Sorge, Robert E, Gkogkas, Christos G, Pawlowski, Sophie Anne, Jafarnejad, Seyed Mehdi, Pitcher, Mark H, Alain, Tommy, Perez-Sanchez, Jimena, Salter, Eric W, Martin, Loren, Ribeiro-da-Silva, Alfredo, De Koninck, Yves, Cervero, Fernando, Mogil, Jeffrey S, Sonenberg, Nahum, eLife, 2015, 10.7554/eLife.12002
A simplified up-down method (SUDO) for measuring mechanical nociception in rodents using von Frey filaments, Bonin, Robert P., Bories, Cyril, De Koninck, Yves, Molecular Pain, 2014, 10.1186/1744-8069-10-26
A spinal analog of memory reconsolidation enables reversal of hyperalgesia, Bonin, Robert P., De Koninck, Yves, Nature Neuroscience, 2014, 10.1038/nn.3758
Automated method for the segmentation and morphometry of nerve fibers in large-scale CARS images of spinal cord tissue, Begin, Steve, Dupont-Therrien, Olivier, Belanger, Erik, Daradich, Amy, Laffray, Sophie, De Koninck, Yves, Cote, Daniel C., Biomedical Optics Express, 2014, 10.1364/BOE.5.004145
Enhancing K-Cl co-transport restores normal spinothalamic sensory coding in a neuropathic pain model, Lavertu, Guillaume, Cote, Sylvain L., De Koninck, Yves, Brain, 2014, 10.1093/brain/awt334
Extended two-photon microscopy in live samples with Bessel beams: steadier focus, faster volume scans, and simpler stereoscopic imaging, Theriault, Gabrielle, Cottet, Martin, Castonguay, Annie, McCarthy, Nathalie, De Koninck, Yves, Frontiers in Cellular Neuroscience, 2014, 10.3389/fncel.2014.00139
Gephyrin Clusters Are Absent from Small Diameter Primary Afferent Terminals Despite the Presence of GABA(A) Receptors, Lorenzo, Louis-Etienne, Godin, Antoine G., Wang, Feng, St-Louis, Manon, Carbonetto, Salvatore, Wiseman, Paul W., Ribeiro-da-Silva, Alfredo, De Koninck, Yves, Journal of Neuroscience, 2014, 10.1523/JNEUROSCI.0159-14.2014
KCC2 : nouvelle cible thérapeutique pour le traitement de pathologies neurologiques, Marc J. Bergeron, Annie Castonguay, Yves De Koninck, Médecine/sciences, 2014, 10.1051/MEDSCI/20143005013
Neutrophils mediate blood-spinal cord barrier disruption in demyelinating neuroinflammatory diseases., Aube, Benoit, Levesque, Sebastien A, Pare, Alexandre, Chamma, Emilie, Kebir, Hania, Gorina, Roser, Lecuyer, Marc-Andre, Alvarez, Jorge I, De Koninck, Yves, Engelhardt, Britta, Prat, Alexandre, Cote, Daniel, Lacroix, Steve, Journal of immunology (Baltimore, Md. : 1950), 2014, 10.4049/jimmunol.1400401
Normal and abnormal coding of somatosensory stimuli causing pain, Prescott, Steven A., Ma, Qiufu, De Koninck, Yves, Nature Neuroscience, 2014, 10.1038/nn.3629
Spatial and temporal pattern of changes in the number of GAD65-immunoreactive inhibitory terminals in the rat superficial dorsal horn following peripheral nerve injury, Lorenzo, Louis-Etienne, Magnussen, Claire, Bailey, Andrea L., St Louis, Manon, De Koninck, Yves, Ribeiro-da-Silva, Alfredo, Molecular Pain, 2014, 10.1186/1744-8069-10-57
Spatial intensity distribution analysis (SpIDA) a method to probe membrane receptor organization in intact cells, Godin, A.G., Rappaz, B., Potvin-Trottier, L., De Koninck, Y., Wiseman, P.W., Cell Membrane Nanodomains: From Biochemistry to Nanoscopy, 2014, 10.1201/b17634
The heterogeneity in GABAA receptor-mediated IPSC kinetics reflects heterogeneity of subunit composition among inhibitory and excitatory interneurons in spinal lamina II, Charalampos Labrakakis, Uwe Rudolph, Yves De Koninck, Frontiers in Cellular Neuroscience, 2014, 10.3389/FNCEL.2014.00424
A multimodal micro-optrode combining field and single unit recording, multispectral detection and photolabeling capabilities., Calakos, Nicole, De Koninck, Yves, Deschenes, Martin, Dufour, Suzie, Dufour-Beausejour, Sophie, Juneau-Fecteau, Alexandre, Lavertu, Guillaume, Vallee, Real, PloS one, 2013, 10.1371/journal.pone.0057703
Chloride extrusion enhancers as novel therapeutics for neurological diseases, Gagnon, Martin, Bergeron, Marc J., Lavertu, Guillaume, Castonguay, Annie, Tripathy, Sasmita, Bonin, Robert P., Perez-Sanchez, Jimena, Boudreau, Dominic, Wang, Bin, Dumas, Lionel, Valade, Isabelle, Bachand, Karine, Jacob-Wagner, Marieve, Tardif, Christian, Kianicka, Irenej, Isenring, Paul, Attardo, Giorgio, Coull, Jeffrey A. M., De Koninck, Yves, Nature Medicine, 2013, 10.1038/nm.3356
Differential Balance of Prefrontal Synaptic Activity in Successful versus Unsuccessful Cognitive Aging, Bories, Cyril, Husson, Zoe, Guitton, Matthieu J., De Koninck, Yves, Journal of Neuroscience, 2013, 10.1523/jneurosci.3258-12.2013
Extended depth of field microscopy for rapid volumetric two-photon imaging, De Koninck, Yves, McCarthy, Nathalie, Theriault, Gabrielle, Optics Express, 2013, 10.1364/oe.21.010095
Local assessment of myelin health in a multiple sclerosis mouse model using a 2D Fourier transform approach, Begin, Steve, Belanger, Erik, Laffray, Sophie, Aube, Benoit, Chamma, Emilie, Belisle, Jonathan, Lacroix, Steve, De Koninck, Yves, Cote, Daniel, Biomedical Optics Express, 2013, 10.1364/BOE.4.002003
Microglia Control Neuronal Network Excitability via BDNF Signalling, Ferrini, Francesco, De Koninck, Yves, Neural Plasticity, 2013, 10.1155/2013/429815
Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl- homeostasis, Ferrini, Francesco, Trang, Tuan, Mattioli, Theresa-Alexandra M., Laffray, Sophie, Del'Guidice, Thomas, Lorenzo, Louis-Etienne, Castonguay, Annie, Doyon, Nicolas, Zhang, Wenbo, Godin, Antoine G., Mohr, Daniela, Beggs, Simon, Vandal, Karen, Beaulieu, Jean-Martin, Cahill, Catherine M., Salter, Michael W., De Koninck, Yves, Nature Neuroscience, 2013, 10.1038/nn.3295
PAK Inactivation Impairs Social Recognition in 3xTg-AD Mice without Increasing Brain Deposition of Tau and A beta, Arsenault, Dany, Dal-Pan, Alexandre, Tremblay, Cyntia, Bennett, David A., Guitton, Matthieu J., De Koninck, Yves, Tonegawa, Susumu, Calon, Frederic, Journal of Neuroscience, 2013, 10.1523/JNEUROSCI.1501-13.2013
Quantification of receptor tyrosine kinase activation and transactivation by G-protein-coupled receptors using spatial intensity distribution analysis (SpIDA)., Barbeau, Annie, Beaulieu, Jean-Martin, De Koninck, Yves, Godin, Antoine G, Swift, Jody L, Wiseman, Paul W, Methods in enzymology, 2013, 10.1016/B978-0-12-407865-9.00007-8
Remote Optogenetic Activation and Sensitization of Pain Pathways in Freely Moving Mice, Daou, Ihab, Tuttle, Alexander H., Longo, Geraldine, Wieskopf, Jeffrey S., Bonin, Robert P., Ase, Ariel R., Wood, John N., De Koninck, Yves, Ribeiro-da-Silva, Alfredo, Mogil, Jeffrey S., Seguela, Philippe, Journal of Neuroscience, 2013, 10.1523/JNEUROSCI.2424-13.2013
Resolution and contrast enhancement in laser scanning microscopy using dark beam imaging, Dehez, Harold, Piche, Michel, De Koninck, Yves, Optics Express, 2013, 10.1364/OE.21.015912
Restoring ionotropic inhibition as an analgesic strategy, Bonin, Robert P., De Koninck, Yves, Neuroscience Letters, 2013, 10.1016/j.neulet.2013.09.047
Spatial intensity distribution analysis (SpIDA): a new tool for receptor tyrosine kinase activation and transactivation quantification, Barbeau A, Swift JL, Godin AG, De Koninck Y, Wiseman PW, Beaulieu JM, Methods in Cell Biology, 2013, 10.1016/B978-0-12-408143-7.00001-3
Treating pathological pain: is KCC2 the key to the gate?, Doyon, Nicolas, Ferrini, Francesco, Gagnon, Martin, De Koninck, Yves, Expert Review of Neurotherapeutics, 2013, 10.1586/ERN.13.40
Live animal myelin histomorphometry of the spinal cord with video-rate multimodal nonlinear microendoscopy, Belanger, Erik, Crepeau, Joel, Laffray, Sophie, Vallee, Real, De Koninck, Yves, Cote, Daniel, Journal of Biomedical Optics, 2012, 10.1117/1.JBO.17.2.021107
Live animal myelin histomorphometry of the spinal cord with video-rate multimodal nonlinear microendoscopy., , Journal of biomedical optics, 2012
P2X 4 receptors influence inflammasome activation after spinal cord injury, de Rivero Vaccari, J.P., Bastien, D., Yurcisin, G., Pineau, I., Dalton Dietrich, W., De Koninck, Y., Keane, R.W., Lacroix, S., Journal of Neuroscience, 2012, 10.1523/JNEUROSCI.4930-11.2012
QRS widening and QT prolongation under bupropion: A unique cardiac electrophysiological profile, , Fundamental and Clinical Pharmacology, 2012, 10.1111/j.1472-8206.2011.00953.x
Sex-Dependent Alterations in Social Behaviour and Cortical Synaptic Activity Coincide at Different Ages in a Model of Alzheimer's Disease, , PLoS ONE, 2012, 10.1371/journal.pone.0046111
Transmission nerveuse de la douleur : mécanismes endogènes de contrôle au niveau spinal, Y De Koninck, Médecine/sciences, 2012, 10.4267/10608/410
A microprobe for parallel optical and electrical recordings from single neurons in vivo, , Nature Methods, 2011, 10.1038/nmeth.1572
Adaptive movement compensation for in vivo imaging of fast cellular dynamics within a moving tissue, , PLoS ONE, 2011, 10.1371/journal.pone.0019928
Efficacy of synaptic inhibition depends on multiple, dynamically interacting mechanisms implicated in chloride homeostasis, , PLoS Computational Biology, 2011, 10.1371/journal.pcbi.1002149
Mechanisms of Plasticity of Inhibition in Chronic Pain Conditions, Labrakakis, Charalampos, Ferrini, Francesco, De Koninck, Yves, Woodin, MA, Maffei, A, Inhibitory Synaptic Plasticity, 2011, 10.1007/978-1-4419-6978-1_7
Morphological and functional characterization of cholinergic interneurons in the dorsal horn of the mouse spinal cord, , Journal of Comparative Neurology, 2011, 10.1002/cne.22668
Pharmacological enhancement of delta-subunit-containing GABA(A) receptors that generate a tonic inhibitory conductance in spinal neurons attenuates acute nociception in mice, Bonin, Robert P., Labrakakis, Charalampos, Eng, David G., Whissell, Paul D., De Koninck, Yves, Orser, Beverley A., Pain, 2011, 10.1016/j.pain.2011.02.011
Quantification of receptor tyrosine kinase transactivation through direct dimerization and surface density measurements in single cells, , Proceedings of the National Academy of Sciences of the United States of America, 2011, 10.1073/pnas.1018280108
Revealing protein oligomerization and densities in situ using spatial intensity distribution analysis, , Proceedings of the National Academy of Sciences of the United States of America, 2011, 10.1073/pnas.1018658108
Modulation of Chloride Homeostasis by Microglia, , 2010, 10.1016/B978-0-12-374373-2.00023-6
Chemokines and pain mechanisms, , Brain Research Reviews, 2009, 10.1016/j.brainresrev.2008.12.002
Dorsal horn neurons presynaptic to lamina I spinoparabrachial neurons revealed by transynaptic labeling, , Journal of Comparative Neurology, 2009, 10.1002/cne.22179
Enhanced resolution in two-photon imaging using a TM01 laser beam at a dielectric interface, DEHEZ, H, PICHE, M, DE KONINCK, Y, OPTICS LETTERS, 2009
Enhanced resolution in two-photon imaging using a TM01 laser beam at a dielectric interface, Dehez, H., Piché, M., De Koninck, Y., Optics Letters, 2009, 10.1364/OL.34.003601
Inhibitory coupling between inhibitory interneurons in the spinal cord dorsal horn, , Molecular Pain, 2009, 10.1186/1744-8069-5-24
Quantitative myelin imaging with coherent anti-Stokes Raman scattering microscopy: Alleviating the excitation polarization dependence with circularly polarized laser beams, , Optics Express, 2009, 10.1364/OE.17.018419
Quantitative myelin imaging with coherent anti-Stokes Raman scattering microscopy: alleviating the excitation polarization dependence with circularly polarized laser beams, BELANGER, E, BEGIN, S, LAFFRAY, S, DE KONINCK, Y, VALLEE, R, COTE, D, OPTICS EXPRESS, 2009
Biophysical basis for three distinct dynamical mechanisms of action potential initiation, , PLoS Computational Biology, 2008, 10.1371/journal.pcbi.1000198
Morphological and Neurochemical Organization of the Spinal Dorsal Horn, Ribeiro-da-Silva, A., De Koninck, Y., The Senses: A Comprehensive Reference, 2008, 10.1016/B978-012370880-9.00163-8
Postnatal changes in the rexed lamination and markers of nociceptive afferents in the superficial dorsal horn of the rat, , Journal of Comparative Neurology, 2008, 10.1002/cne.21691
Pyramidal neurons switch from integrators in vitro to resonators under in vivo-like conditions, , Journal of Neurophysiology, 2008, 10.1152/jn.90634.2008
Altered chloride homeostasis in neurological disorders: a new target, , Current Opinion in Pharmacology, 2007, 10.1016/j.coph.2006.11.005
Dendritic spine viscoelasticity and soft-glassy nature: Balancing dynamic remodeling with structural stability, , Biophysical Journal, 2007, 10.1529/biophysj.106.092361
Expression of CCR2 in both resident and bone marrow-derived microglia plays a critical role in neuropathic pain, , Journal of Neuroscience, 2007, 10.1523/JNEUROSCI.3016-07.2007
Transformation of the output of spinal lamina I neurons after nerve injury and microglia stimulation underlying neuropathic pain, , Molecular Pain, 2007, 10.1186/1744-8069-3-27
Imbalance towards inhibition as a substrate of aging-associated cognitive impairment, , Neuroscience Letters, 2006, 10.1016/j.neulet.2005.11.055
Microscopie à deux photons pour l’imagerie cellulaire fonctionnelle : avantages et enjeux ou Un photon c’est bien… mais deux c’est mieux !, Suzie Dufour, Annie Castonguay, Nathalie McCarthy, Yves De Koninck, Médecine/sciences, 2006, 10.1051/MEDSCI/20062210837
Nonlinear interaction between shunting and adaptation controls a switch between integration and coincidence detection in pyramidal neurons, , Journal of Neuroscience, 2006, 10.1523/JNEUROSCI.1388-06.2006
Reduction of anion reversal potential subverts the inhibitory control of firing rate in spinal lamina I neurons: Towards a biophysical basis for neuropathic pain, , Molecular Pain, 2006, 10.1186/1744-8069-2-32
Spatial and temporal relationship between monocyte chemoattractant protein-1 expression and spinal glial activation following peripheral nerve injury, , Journal of Neurochemistry, 2006, 10.1111/j.1471-4159.2006.03746.x
Two-photon excitation fluorescence microscopy with a high depth of field using an axicon, , Applied Optics, 2006, 10.1364/AO.45.009246
BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain, , Nature, 2005, 10.1038/nature04223
Destruction of polymer growth substrates for cell cultures in two-photon microscopy, , Journal of Microscopy, 2005, 10.1111/j.1365-2818.2005.01523.x
Differential maturation of GABA action and anion reversal potential in spinal lamina I neurons: Impact of chloride extrusion capacity, , Journal of Neuroscience, 2005, 10.1523/JNEUROSCI.1488-05.2005
Integration time in a subset of spinal lamina I neurons is lengthened by sodium and calcium currents acting synergistically to prolong subthreshold depolarization, , Journal of Neuroscience, 2005, 10.1523/JNEUROSCI.0356-05.2005
Morphology and neurokinin 1 receptor expression of spinothalamic lamina I neurons in the rat spinal cord, , Journal of Comparative Neurology, 2005, 10.1002/cne.20675
Role of cation-chloride-cotransporters (CCC) in pain and hyperalgesia, , Current Topics in Medicinal Chemistry, 2005, 10.2174/1568026054367629
Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain, , 2003, 10.1038/nature01868
Gain control of firing rate by shunting inhibition: Roles of synaptic noise and dendritic saturation, , Proceedings of the National Academy of Sciences of the United States of America, 2003, 10.1073/pnas.0337591100
Aging causes a preferential loss of cholinergic innervation of characterized neocortical pyramidal neurons, M. A. Casu, Wong TP, De Koninck Y, Ribeiro-da-Silva A, Cuello AC, Cerebral Cortex (New York, N.Y.), 2002, 10.1093/CERCOR/12.3.329
Four cell types with distinctive membrane properties and morphologies in lamina I of the spinal dorsal horn of the adult rat, , Journal of Physiology, 2002, 10.1113/jphysiol.2001.013437
Imaging physical properties and dynamics of dendritic spines by atomic force microscopy, , Microscopy and Microanalysis, 2002
Cholinergic nerve terminals establish classical synapses in the rat cerebral cortex: Synaptic pattern and age-related atrophy, , Neuroscience, 2001, 10.1016/S0306-4522(01)00172-5
Region-specific developmental specialization of GABA-glycine cosynapses in laminas I-II of the rat spinal dorsal horn, , Journal of Neuroscience, 2001
Differential progression of Dark Neuron and Fluoro-Jade labelling in the rat hippocampus following pilocarpine-induced status epilepticus, , Neuroscience, 2000, 10.1016/S0306-4522(00)00026-9
GABA(B) receptors are the first target of released GABA at lamina I inhibitory synapses in the adult rat spinal cord, Yves De Koninck, Journal of Neurophysiology, 2000
Loss of presynaptic and postsynaptic structures is accompanied by compensatory increase in action potential-dependent synaptic input to layer V neocortical pyramidal neurons in aged rats, , Journal of Neuroscience, 2000
Visualization of lamina I of the dorsal horn in live adult rat spinal cord slices, , Journal of Neuroscience Methods, 2000, 10.1016/S0165-0270(99)00195-8
An ambiguous fast synapse: A new twist in the tale of two transmitters, , Nature Neuroscience, 1999, 10.1038/6296
Junctional versus extrajunctional glycine and GABA(A) receptor-mediated IPSCs in identified lamina I neurons of the adult rat spinal cord, , Journal of Neuroscience, 1999
NK-1 receptor immunoreactivity in distinct morphological types of lamina I neurons of the primate spinal cord, , Journal of Neuroscience, 1999
Endogenous GABA activates small-conductance K⁺ channels underlying slow IPSCs in rat hippocampal neurons, De Koninck, Y., Mody, I., Journal of Neurophysiology, 1997, 10.1152/jn.1997.77.4.2202
Pain transmission: Endogenous spinal control mechanisms,Transmission nerveuse de la douleur: Mechanismes endogenes de controle au niveau spinal, De Koninck, Y., Medecine/Sciences, 1997
Substance P and enkephalin immunoreactivities in axonal boutons presynaptic to physiologically identified dorsal horn neurons. An ultrastructural multiple-labelling study in the cat, , Neuroscience, 1997, 10.1016/S0306-4522(96)00510-6
Properties of K⁺ channels linked to GABA(B) receptors activated by endogenously released GABA, Mody, I., De Koninck, Y., Pharmacology Communications, 1996
Quantitative analysis of substance P-immunoreactive boutons on physiologically characterized dorsal horn neurons in the cat lumbar spinal cord, Alfredo Ribeiro-da-Silva, Journal of Comparative Neurology, 1996, 10.1002/(SICI)1096-9861(19961202)376:1<45::AID-CNE3>3.0.CO;2-O
The effects of raising intracellular calcium on synaptic GABA(A) receptor-channels, , Neuropharmacology, 1996, 10.1016/S0028-3908(96)00063-9
Reply, Yves De Koninck, Istvan Mody, Trends in Neurosciences, 1995, 10.1016/0166-2236(95)80006-N
Bridging the cleft at GABA synapses in the brain, , Trends in Neurosciences, 1994, 10.1016/0166-2236(94)90155-4
Lasting potentiation of inhibition is associated with an increased number of γ-aminobutyric acid type A receptors activated during miniature inhibitory postsynaptic currents, , Proceedings of the National Academy of Sciences of the United States of America, 1994, 10.1073/pnas.91.16.7698
Noise analysis of miniature IPSCs in adult rat brain slices: Properties and modulation of synaptic GABA(A) receptor channels, , Journal of Neurophysiology, 1994
Prolonged GABAA‐mediated inhibition following single hair afferent input to single spinal dorsal horn neurones in cats., De Koninck, Y., Henry, J.L., The Journal of Physiology, 1994, 10.1113/jphysiol.1994.sp020114
Substance P released endogenously by high-intensity sensory stimulation potentiates purinergic inhibition of nociceptive dorsal horn neurons induced by peripheral vibration, , Neuroscience Letters, 1994, 10.1016/0304-3940(94)90887-7
An inhibitory postsynaptic potential in spinal nociceptive neurones is mediated by adenosine through activation of ATP‐sensitive K⁺ channels, Salter, M.W., De Koninck, Y., Henry, J.L., Drug Development Research, 1993, 10.1002/ddr.430280342
Characterization of synaptically elicited GABAB responses using patch‐clamp recordings in rat hippocampal slices., Otis, T.S., De Koninck, Y., Mody, I., The Journal of Physiology, 1993, 10.1113/jphysiol.1993.sp019600
Organization of substance P primary sensory neurons: ultrastructural and physiological correlates, Cuello, A.C., Ribeiro-da-Silva, A., Ma, W., De Koninck, Y., Henry, J.L., Regulatory Peptides, 1993, 10.1016/0167-0115(93)90026-5
Physiological roles for adenosine and ATP in synaptic transmission in the spinal dorsal horn, , Progress in Neurobiology, 1993, 10.1016/0301-0082(93)90006-E
Properties of NMDA receptor channels in neurons acutely isolated from epileptic (kindled) rats, , Journal of Neuroscience, 1993
ATP‐Sensitive K⁺ channels mediate an IPSP in dorsal horn neurones elicited by sensory stimulation, Salter, M.W., De Koninck, Y., Henry, J.L., Synapse, 1992, 10.1002/syn.890110306
Enkephalin-immunoreactive nociceptive neurons in the cat spinal cord, A. Ribeiro-da-Silva, Y. De Koninck, A. C. Cuello, J. L. Henry, NeuroReport, 1992, 10.1097/00001756-199201000-00006
Peripheral vibration causes an adenosine-mediated postsynaptic inhibitory potential in dorsal horn neurons of the cat spinal cord, , Neuroscience, 1992, 10.1016/0306-4522(92)90435-5
Spinal neurons exhibiting a specific nociceptive response receive abundant substance P-containing synaptic contacts, , Proceedings of the National Academy of Sciences of the United States of America, 1992, 10.1073/pnas.89.11.5073
Substance P-mediated slow excitatory postsynaptic potential elicited in dorsal horn neurons in vivo by noxious stimulation, , Proceedings of the National Academy of Sciences of the United States of America, 1991
Le Rôle des purines dans la modulation de la douleur au niveau spinal par la stimulation d'afférences non nociceptives, Salter, M.W., De Koninck, Y., Henry, J.L., Douleur et Analgésie, 1990, 10.1007/BF03009146
Bombesin, neuromedin B and neuromedin C selectively depress superficial dorsal horn neurones in the cat spinal cord, Yves De Koninck, James L. Henry, Brain Research, 1989, 10.1016/0006-8993(89)90404-6

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Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009

Louison Brochoire - Doctorat - En cours
Mohamad Feshki - Doctorat - En cours
Susana Lima - Doctorat - En cours
Charline Sahara Khademullah-Coskun - Post-doctorat - En cours
Reza Hazrati - Doctorat - En cours
Nicola Forte - Post-doctorat - En cours
Iason Keramidis - Doctorat - En cours
Dominique Isabel - Maitrîse avec mémoire - En cours
Einer Munoz Pino - Doctorat - En cours
Isabel Plasencia Fernandez - Post-doctorat - En cours
Axelle Dovonou - Doctorat - En cours
Samuel Ferland - Doctorat - En cours
Petra Horakova - Doctorat - En cours
Bruce Mesnage - Doctorat - En cours
Julien Bourbonnais - Maitrîse avec mémoire - En cours
Félix Desrosiers - Doctorat - En cours
Émilie Chamma - Maitrîse avec mémoire - 2013/09
Louis Thibon - Doctorat - 2019/01
Mehdi Noormohammadi Khiarak - Doctorat - 2019/01
Melina Papalampropoulou-Tsiridou - Doctorat - 2021/05

*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.

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