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Yohan Bossé

Professeur titulaire

Directeur(trice), Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec

Directeur(trice), Centre de recherche de l'IUCPQ

Yohan Bossé
Yohan.Bosse@criucpq.ulaval.ca
Centre de recherche sur le cancer
Groupe de recherche en santé respiratoire
Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec
Centre de recherche de l'IUCPQ
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Bioinformatique / données massives (big data)
Oncologie
Santé cardiovasculaire, respiratoire et métabolisme

Domaines et intérêts de recherche du (de la) professeur(e) :

Cancer
  • Cancer du poumon
Génétique humaine
  • Génomique
  • Génétique de traits complexes
  • Gènes de susceptibilité
  • Dépistage génétique des maladies
  • Micropuces d'ADN et d'ARN
Santé circulatoire et respiratoire
  • Maladie pulmonaire obstructive chronique
  • Asthme

Projets de recherche

  • Molecular and Genetic Epidemiology to Understand Mitral Valve Prolapse - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2024-04-01 au 2029-03-31
  • Programme VISION - Fonds de recherche du Québec - Santé - Tremplin, co-chercheur - 2022-11-15 au 2026-03-31
  • Canada Research Chair in Genomics of Heart and Lung Diseases - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2020-07-01 au 2025-06-30
  • Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
  • Air pollution, climate and COPD: acute and long-term impacts in Canadian populations - Instituts de recherche en santé du Canada - Subvention Projet, McGill University, co-chercheur - 2021-04-01 au 2025-03-31
  • Sex and sex-hormones determine pulmonary morphological and single-nucleus transcriptomic responses in an animal model of sleep apnea. - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2024-03-01 au 2025-02-28
  • Différentiation sexuelle des réponses pulmonaires par séquençage d’ARN en cellules uniques - Fondation J.-D.-Bégin, co-chercheur - 2023-01-01 au 2024-12-31
  • The Quebec City Idiopathic Pulmonary Fibrosis Cohort: A resource fo clinical and genetic research - Fondation de l'Institut universitaire de cardiologie et de pneumologie de Québec, chercheur principal - 2023-01-01 au 2024-12-31
  • Deciphering the role of PTPN6/SHP-1 and its mutant PTPN6/SHP-1Ala455Thr in the development of pulmonary emphysema - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2019-10-01 au 2024-09-30
  • A transcriptome- and proteome-wide association study of non-alcoholic fatty liver disease - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2021-10-01 au 2024-09-30
  • Integrative genomics and functional analyses to uncover the molecular mechanisms involved in bicuspid aortic valve disease - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2019-04-01 au 2024-03-31
  • Analyse statistique des liens entre blocs de variables de format mixte. Applications en épidémiologie, génomique et sécurité sanitaire. - Fonds de recherche du Québec - Nature et technologies - Programme Samuel-De Champlain, co-chercheur - 2022-04-01 au 2024-03-31
  • Elucidating the role of lipoprotein(a) in calcific aortic valve stenosis using novel proteomic and imaging approaches - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2019-10-01 au 2023-09-30
  • A genome-wide association study of dysanapsis - Instituts de recherche en santé du Canada - Subvention Projet, McGill University, co-chercheur - 2020-04-01 au 2023-03-31
  • Functional and clinical characterization of PALMD calcific aortic valve stenosis risk locus - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2018-10-01 au 2023-03-31
  • Finding the molecular drivers of calcific aortic valve stenosis - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2018-10-01 au 2023-03-31
  • Blood Epigenetic Age Biomarkers and Health Outcomes in COPD - Instituts de recherche en santé du Canada - Subvention Projet, University of British Columbia, co-chercheur - 2022-10-01 au 2023-03-31
  • Liking clinical, research and imaging data in lung cancer: towards FAIR and AI-ready datasets - Société canadienne du cancer - Subventions de transformation de données sur le cancer, co-chercheur - 2022-03-15 au 2023-03-14
  • The IUCPQ-UL cases series of patients with idiopathic pulmonary fibrosis: A resource for clinical and genetic research - Fondation de l'Institut universitaire de cardiologie et de pneumologie de Québec, chercheur principal - 2022-01-01 au 2022-12-31
  • Copy Number Variation and Lung Cancer: Disease Risk and Mechanisms - National Institute of Health (USA) - R21 Exploratory Research Grant (PA-17-243), University of South Carolina , co-chercheur - 2020-09-01 au 2022-08-30
  • Multi-omic approach to sex-differences in aortic stenosis - Fondation des maladies du coeur et de l'AVC du Canada, co-chercheur - 2021-07-01 au 2022-06-30
  • Identification of novel therapeutic targets for calcific aortic valve stenosis using integrative genomics - Fondation des maladies du coeur et de l'AVC du Canada - Subventions de recherche, co-chercheur - 2019-07-01 au 2022-06-30
  • Genomic predictors of smoking and lung cancer risk - National Institute of Health (USA) - Subvention de recherche, Geisel School of Medicine at Dartmouth, co-chercheur - 2017-08-01 au 2022-05-31
  • Stage d'été « Carrière été » - Emploi et Développement Social Canada (EDSC), chercheur principal - 2021-05-03 au 2021-06-25

Publications

  • Surfactant protein D is a causal risk factor for COPD: results of Mendelian randomisation, Don D. Sin, Peter D. Paré, Kathleen C. Barnes, Terri H. Beaty, Ingo Ruczinski, Rasika Mathias, Nicholas Rafaels, Rayjean J. Hung, Marike Boezen, Kim de Jong, Brian D. Hobbs, Michael H. Cho, Wim Timens, Maarten van den Berge, David C. Nickle, Ke Hao, Philippe Joubert, Yohan Bossé, Nadia N. Hansel, Nick Fishbane, Guohai Zhou, Stephen Burgess, Xuan Li, Ma'en Obeidat, European Respiratory Journal, 2017, 10.1183/13993003.00657-2017
  • Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility, Rayjean J. Hung, John S. Witte, Paul Brennan, Christopher I. Amos, Philip C. Haycock, George Davey Smith, Caroline Relton, Richard M. Martin, Ma’en Obeidat, Yonathan Brhane, Matthew T. Warkentin, Nima C. Emami, James D. McKay, Susanne Arnold, Philip Lazarus, Jonas Manjer, Angeline S. Andrew, Eric J. Duell, Matthew B. Schabath, Iona Cheng, Loïc Le Marchand, Stephen Lam, Shanbeh Zienolddiny, Aage Haugen, Stig E. Bojesen, Lambertus A. Kiemeney, M. Dawn Teare, Michael P. Davies, John K. Field, Heike Bickeböller, Jennifer A. Doherty, Gary E. Goodman, Chu Chen, Gad Rennert, Adonina Tardón, Melinda C. Aldrich, Demetrius Albanes, Sanjay S. Shete, David Zaridze, Ghislaine Scelo, Geoffrey Liu, Paolo Vineis, David C. Christiani, Maria Teresa Landi, Neil E. Caporaso, Venkata Manem, Yohan Bossé, Rebecca E. Graff, Sara R. Rashkin, Mattias Johansson, Linda Kachuri, Nature Communications, 2020, 10.1038/s41467-019-13855-2
  • Genome-Wide Interaction Analysis of Air Pollution Exposure and Childhood Asthma with Functional Follow-up, Erik Melén, Göran Pershagen, Christopher Carlsten, Dirkje Postma, Gerard H. Koppelman, Juha Kere, Joachim Heinrich, W. James Gauderman, Bert Brunekreef, Jean Bousquet, Michael Brauer, Charles Auffray, Josep M. Antó, Cheng-Jian Xu, Hita Vora, Judith M. Vonk, Maarten van den Berge, Carla M. T. Tiesler, Cilla Söderhäll, Annika Sääf, Marie Standl, Johann Pellet, Ma'en Obeidat, David Nickle, Camille Ménard, Elaina MacIntyre, Nathanaël Lemonnier, Ashish Kumar, Anita L. Kozyrskyj, Michal Korek, Michael S. Kobor, Meaghan Jones, Stéphane Joly, Ruiwei Jiang, Despo Ierodiakonou, Elaine Fuertes, Moira Chan-Yeung, Matteo Bottai, Yohan Bossé, Anna Bergström, Tom Bellander, Allan Becker, Stéphane Ballereau, Olena Gruzieva, Simon K. Merid, Anna Gref, American Journal of Respiratory and Critical Care Medicine, 2017, 10.1164/rccm.201605-1026OC
  • Transcriptome‐wide association study reveals candidate causal genes for lung cancer, James D. McKay, Christopher I. Amos, Philippe Joubert, Rayjean J. Hung, Wim Timens, Ma'en Obeidat, Shan Zienolddiny, Penella Woll, H‐Erich Wichmann, Adonina Tardon, Victoria L. Stevens, Zhuoyi Song, Sanjay Shete, Matthew B. Schabath, Susan M. Rosenberg, Angela Risch, Gadi Rennert, Olle Melander, Geoffrey Liu, Loic Le Marchand, Philip Lazarus, Maria T. Landi, Stephen Lam, Lambertus A. Kiemeney, Mikael Johansson, Mattias Johansson, Richard Houlston, Kjell Grankvist, Gary Goodman, John K. Field, David C. Christiani, Chu Chen, Neil Caporaso, Hans Brunnstrom, Paul Brennan, Stig E. Bojesen, Heike Bickeböller, Susanne Arnold, Angeline Andrew, Melinda C. Aldrich, Demetrius Albanes, Nathalie Gaudreault, Aurélie Gabriel, Robert Carreras‐Torres, Venkata Manem, Jun Xia, Zhonglin Li, Yohan Bossé, International Journal of Cancer, 2020, 10.1002/ijc.32771
  • Differential lung tissue gene expression in males and females: implications for the susceptibility to develop COPD, Dirkje S. Postma, Wim Timens, Francesca Colombo, Tommaso A. Dragani, Ma'en Obeidat, Ke Hao, David C. Nickle, Michel Laviolette, Yohan Bossé, Don D. Sin, Peter D. Paré, Senani N.H. Rathnayake, Maaike de Vries, Alen Faiz, Corry-Anke Brandsma, Maarten van den Berge, European Respiratory Journal, 2019, 10.1183/13993003.02567-2017
  • Tobacco Smoking Increases the Lung Gene Expression of ACE2, the Receptor of SARS-CoV-2, Christopher I. Amos, Farrah Kheradmand, Feifei Xiao, Yohan Bossé, Guoshuai Cai, American Journal of Respiratory and Critical Care Medicine, 2020, 10.1164/rccm.202003-0693LE
  • Genome-wide chromatin contacts of super-enhancer-associated lncRNA identify LINC01013 as a regulator of fibrosis in the aortic valve, Patrick Mathieu, Yohan Bossé, Sébastien Thériault, Zhonglin Li, Valentin Bon-Baret, Ghada Mkannez, Marie-Chloé Boulanger, Déborah Argaud, Arnaud Chignon, PLOS Genetics, 2022, 10.1371/journal.pgen.1010010
  • Oxyphospholipids in Cardiovascular Calcification, Patrick Mathieu, Yohan Bossé, Marie-Chloé Boulanger, Valentin Bon-Baret, Arnaud Chignon, Arteriosclerosis, Thrombosis, and Vascular Biology, 2021, 10.1161/ATVBAHA.120.313790
  • System Genetics Including Causal Inference Identify Immune Targets for Coronary Artery Disease and the Lifespan, Patrick Mathieu, Yohan Bossé, Sébastien Thériault, Benoit J. Arsenault, Deborah Argaud, Zhonglin Li, Marie-Chloé Boulanger, Arnaud Chignon, Valentin Bon-Baret, Circulation: Genomic and Precision Medicine, 2021, 10.1161/CIRCGEN.120.003196
  • The Null Q0Ourém Variant within a Copy-Neutral Loss-of-Heterozygosity Event Causing Alpha-1 Antitrypsin Deficiency, Yohan Bossé, François Maltais, Julie Milot, Annie Haillot, Claudia Blouin, Nathalie Gaudreault, American Journal of Respiratory Cell and Molecular Biology, 2022, 10.1165/rcmb.2021-0564LE
  • Phenome-wide analyses establish a specific association between aortic valve PALMD expression and calcific aortic valve stenosis, Sébastien Thériault, Yohan Bossé, Patrick Mathieu, Benoit J. Arsenault, Nathalie Gaudreault, Zhonglin Li, Communications Biology, 2020, 10.1038/s42003-020-01210-x
  • Whole Exome Sequencing of Highly Aggregated Lung Cancer Families Reveals Linked Loci for Increased Cancer Risk on Chromosomes 12q, 7p, and 4q, Joan E. Bailey-Wilson, Christopher I. Amos, Susan M. Pinney, Ann G. Schwartz, Marshall W. Anderson, Elena Y. Kupert, Richard K. Wilson, Ramaswamy Govindan, Ming You, Yafang Li, Ping Yang, Colette Gaba, Mariza de Andrade, Diptasri Mandal, Yohan Bossé, Claudio W. Pikielny, Haiming Sun, Bilal A. Moiz, Anthony M. Musolf, Cancer Epidemiology, Biomarkers & Prevention, 2020, 10.1158/1055-9965.EPI-19-0887
  • Genome-wide interaction analysis identified low-frequency variants with sex disparity in lung cancer risk, Christopher Amos, Paul Brennan, Colette Gaba, James Willey, Diptasri Mandal, Susan Pinney, Yanhong Liu, Joan Bailey-Wilson, Younghun Han, Ping Yang, Kristen Purrington, Ivan Gorlov, Ann Schwartz, Melinda Aldrich, Matthew Schabath, Philip Lazarus, Michael Davies, Yun-Chul Hong, Dawn Teare, Neil Caporaso, Mikael Johansson, Kjell Grankvist, Shanbeh Zienolddiny, Ryan Sun, Hongbing Shen, Lambertus Kiemeney, Angeline Andrew, Rayjean Hung, Geoffrey Liu, Hans Brunnström, Olle Melander, Loic Le Marchand, Sanjay Shete, John Field, Gary Goodman, Susanne Arnold, Gad Rennert, David Christiani, Erich Wichmann, Heike Bickeböller, Angela Risch, Mattias Johansson, Maria Landi, Stig Bojesen, Chu Chen, Adonina Tardon, Stephen Lam, Demetrius Albanes, James McKay, Yohan Bossé, Chao Cheng, Jinyoung Byun, Jianrong Li, Xiangjun Xiao, Yafang Li, 2021, 10.21203/rs.3.rs-647012/v1
  • SARS-CoV-2 Impairs Dendritic Cells and Regulates DC-SIGN Gene Expression in Tissues, Feifei Xiao, Christopher I. Amos, Michael L. Whitfield, David C. Christiani, Prakash Nagarkatti, Mitzi Nagarkatti, Chao Cheng, Xiao Michelle Androulakis, Xizhi Luo, Fei Qin, Helmut Albrecht, Yohan Bossé, Mulong Du, Guoshuai Cai, International Journal of Molecular Sciences, 2021, 10.3390/ijms22179228
  • Leucocyte-Derived Micro-RNAs as Candidate Biomarkers in Brugada Syndrome, Yohan Bossé, François Philippon, Alan Spatz, Christian Steinberg, 2023, 10.1093/europace/euad145
  • A Polygenic Risk Score for Coronary Artery Disease Improves the Prediction of Early-Onset Myocardial Infarction and Mortality in Men, Sébastien Thériault, Benoit J. Arsenault, Yohan Bossé, Patrick Mathieu, Christian Couture, Zhonglin Li, Nicolas Perrot, Aida Eslami, Hasanga D. Manikpurage, 2021, 10.1101/2021.04.25.21256083
  • Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis, Michael H Cho, H Marike Boezen, Edwin K Silverman, Martin D Tobin, William MacNee, Dirkje S Postma, David A Schwartz, Tasha E Fingerlin, Megan Hardin, Pawel Sliwinski, Iwona Hawrylkiewicz, Deog Kyeom Kim, Jae-Joon Yim, David A Lomas, Dandi Qiao, Deborah A Meyers, Prescott G Woodruff, Eugene R Bleecker, Elizabeth J Ampleford, André G Uitterlinden, Bruno H Stricker, Guy G Brusselle, Lies Lahousse, Amund Gulsvik, Per Bakke, Augusto A Litonjua, David Sparrow, R Graham Barr, Stephen S Rich, Xin-Qun Wang, Ani Manichaikul, Yohannes Tesfaigzi, Steven A Belinsky, Shuguang Leng, Harry J de Koning, Judith M Vonk, Yeon-Mok Oh, Mi Kyeong Lee, Woo Jin Kim, Jemma B Wilk, George T O'Connor, Josée Dupuis, Jeanne C Latourelle, Peter D Paré, Wim Timens, Jørgen Vestbo, Stephen I Rennard, Ruth Tal-Singer, Nicholas Locantore, H J Groen, Matthijs Oudkerk, Jan W Lammers, Pieter Zanen, Sina A Gharib, Bruce M Psaty, Susan R Heckbert, Traci M Bartz, Robert P Chase, Peter J Castaldi, James D Crapo, John E Hokanson, Terri H Beaty, David P Strachan, Nora Franceschini, Kari E North, Stephanie J London, Annah B Wyss, Victoria E Jackson, Ian P Hall, Louise V Wain, María Soler Artigas, Nick Shrine, Yohan Bossé, Maxime Lamontagne, Kim de Jong, Brian D Hobbs, Nature Genetics, 2017, 10.1038/ng.3752
  • Identification of Drug Candidates to Suppress Cigarette Smoke–induced Inflammation via Connectivity Map Analyses, Martin R. Stampfli, John A. Hassell, Yohan Bossé, Ma’en Obeidat, Corry-Anke Brandsma, Pamela Shen, Anna Dvorkin-Gheva, Gilles Vanderstocken, American Journal of Respiratory Cell and Molecular Biology, 2018, 10.1165/rcmb.2017-0202OC
  • A Mendelian randomization study of IL6 signaling in cardiovascular diseases, immune-related disorders and longevity, Patrick Mathieu, Sébastien Thériault, Yohan Bossé, Benoit J. Arsenault, Marie-Chloé Boulanger, Zhonglin Li, Arnaud Chignon, Mickael Rosa, npj Genomic Medicine, 2019, 10.1038/s41525-019-0097-4
  • Calcific aortic valve disease: mechanisms, prevention and treatment, Patrick Mathieu, Yohan Bossé, Mewen Briend, Louis-Hippolyte Minvielle Moncla, Nature Reviews Cardiology, 2023, 10.1038/s41569-023-00845-7
  • Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers, Paul Brennan, Rayjean J. Hung, Richard S. Houlston, Xiangjun Xiao, Ma’en Obeidat, Wim Timens, Gabriella Cadoni, Stefania Boccia, Hans Brunnström, Olle Melander, Susanne Arnold, Mikael Johansson, Kjell Grankvist, Philip Lazarus, Gary M. Clifford, Angeline S. Andrew, Eloiza H. Tajara, Victor Wünsch-Filho, Matthew B. Schabath, Loic Le Marchand, Steve Thomas, Andy R. Ness, Heike Bickeböller, Angela Risch, Martin Lacko, Mark C. Weissler, Andrew F. Olshan, Stephen Lam, Shanbeh Zienolddiny, Robert L. Ferris, Brenda Diergaarde, Lambertus A. Kiemeney, Marion Dawn Teare, John K. Field, Liloglou Triantafillos, Chu Chen, Adonina Tardon, Melinda C. Aldrich, Demetrius Albanes, Gadi Rennert, Geoffrey Liu, Sanjay Shete, Christopher I. Amos, Stig E. Bojesen, Neil C. Caporaso, David C. Christiani, Maria Teresa Landi, Valerie Gaborieau, Mattias Johansson, Yohan Bossé, James D. McKay, Aida Ferreiro-Iglesias, Corina Lesseur, PLOS Genetics, 2021, 10.1371/journal.pgen.1009254
  • Electronic Health Record-Based Genome-Wide Meta-Analysis and Mendelian Randomization Identify Metabolic and Phenotypic Consequences of Non-Alcoholic Fatty Liver Disease, Benoit Arsenault, Tõnu Esko, André Tchernof, Sébastien Thériault, Marie-Claude Vohl, Patrick Mathieu, Yohan Bossé, Patricia Mitchell, Christian Couture, Nicolas Perrot, Alexis St-Amand, Nele Taba, Émilie Gobeil, Erik Abner, Nooshin Ghodsian, 2020, 10.21203/rs.3.rs-97977/v1
  • Identification of Gender-Specific Genetic Variants in Patients With Bicuspid Aortic Valve, Yohan Bossé, Patrick Mathieu, Philippe Pibarot, Cyndi Henry, Laura Sbarra, Nathalie Gaudreault, Maxime Lamontagne, Natasha Dargis, The American Journal of Cardiology, 2016, 10.1016/j.amjcard.2015.10.058
  • A Trans-Omic Mendelian Randomization Study of Parental Lifespan Uncovers Novel Aging Biology and Drug Candidates for Human Healthspan Extension, Benoit J Arsenault, Patrick Mathieu, Sebastien Theriault, Yohan Bosse, Nooshin Ghodsian, Patricia Mitchell, Zhonglin Li, Christian Couture, Jerome Bourgeault, William Pelletier, Nicolas Perrot, 2020, 10.1101/2020.07.06.20147520
  • Autoantibodies and immune complexes to oxidation-specific epitopes and progression of aortic stenosis: Results from the ASTRONOMER trial, Sotirios Tsimikas, Philippe Pibarot, Jean-Pierre Després, Benoit J. Arsenault, Joseph L. Witztum, Xiaohong Yang, Koon K. Teo, James W. Tam, Jean G. Dumesnil, Yohan Bossé, Patrick Mathieu, Kwan L. Chan, Romain Capoulade, Atherosclerosis, 2017, 10.1016/j.atherosclerosis.2017.03.013
  • High FA2H and UGT8 transcript levels predict hydroxylated hexosylceramide accumulation in lung adenocarcinoma, David Marsolais, Anthony S. Don, Philippe Joubert, Yohan Bossé, Andréanne Gagné, Giuleta Jamsari, Timothy A. Couttas, Olivier Courtemanche, Anne-Marie Lemay, Journal of Lipid Research, 2019, 10.1194/jlr.M093955
  • Transcriptomic data helps refining classification of pulmonary carcinoid tumors with increased mitotic counts, Philippe Joubert, Yohan Bossé, Patrice Desmeules, Nathalie Gaudreault, Babak Khoshkrood-Mansoori, Michèle Orain, Venkata Manem, Olga Sazonova, Modern Pathology, 2020, 10.1038/s41379-020-0538-8
  • A Potent Tartrate Resistant Acid Phosphatase Inhibitor to Study the Function of TRAP in Alveolar Macrophages, Barbro N. Melgert, Angela Casini, Wim Timens, Peter Olinga, Göran Andersson, Anja Reithmeier, Ke Hao, Don Sin, Yohan Bossé, Maarten van den Berge, Corry-Anke Brandsma, Gyorgy Fejer, Thais Mauad, Christina Draijer, Andreia de Almeida, Kurnia S. S. Putri, T. Anienke van der Veen, Carian E. Boorsma, Scientific Reports, 2017, 10.1038/s41598-017-12623-w
  • UCP1 expression–associated gene signatures of human epicardial adipose tissue, Denis Richard, Elin Grundberg, Andre Tchernof, Yohan Bossé, Patrick Mathieu, Pierre Voisine, Jinchu Vijay, Kanta Chechi, JCI Insight, 2019, 10.1172/jci.insight.123618
  • The Overlap of Lung Tissue Transcriptome of Smoke Exposed Mice with Human Smoking and COPD, Don D. Sin, Martin R. Stampfli, Peter D. Paré, Alvar Agusti, Rosa Faner, Philip M. Hansbro, David C. Nickle, Corry-Anke Brandsma, Yohan Bossé, Xuan Li, Anna Dvorkin-Gheva, Ma’en Obeidat, Scientific Reports, 2018, 10.1038/s41598-018-30313-z
  • Benefits and limitations of genome-wide association studies, David Meyre, Guillaume Paré, Yohan Bossé, Michelle Turcotte, Nikunj Patel, Vivian Tam, Nature Reviews Genetics, 2019, 10.1038/s41576-019-0127-1
  • Cardiac reverse remodeling in a mouse model with many phenotypical features of heart failure with preserved ejection fraction: effects of modifying lifestyle, Jacques Couët, Yohan Bossé, Marie Arsenault, Dominique K. Boudreau, Geneviève Gagnon, Audrey Morin-Grandmont, Emylie-Ann Labbé, Sara-Ève Thibodeau, Élisabeth Walsh-Wilkinson, Mohamed Lamine Aidara, American Journal of Physiology-Heart and Circulatory Physiology, 2024, 10.1152/ajpheart.00462.2023
  • The journey towards identification of actionable molecular pathways in calcific aortic valve stenosis, Yohan Bossé, Patrick Mathieu, Sébastien Thériault, European Heart Journal, 2023, 10.1093/eurheartj/ehad134
  • Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk, Christopher I. Amos, Paul Brennan, Stephen Chanock, Wei-Qi Wei, Rachel F. Tyndale, Dakai Zhu, Ahsan Kamal, Jinyoung Byun, Fangyi Gu, Louise V. Wain, Martin D. Tobin, María Soler Artigas, Lei Song, Bin Zhu, Wim Timens, Ma’en Obeidat, David C. Nickle, Victoria Stevens, John McLaughlin, Richard Houlston, Yu-Tang Gao, Woon-Puay Koh, Lesley M. Butler, Eric J. Duell, Shanbeh Zienolddiny, Vidar Skaug, Per Bakke, David Zaridze, Beata Swiatkowska, Ghislaine Scelo, Tadeusz M. Orlowski, Simona Ognjanovic, Anush Mukeria, Jolanta Lissowska, Milica Kontic, Vladimir Janout, Ivana Holcatova, Ciprian Bolca, Eric B. Haura, Susanne M. Arnold, Ming-Sound Tsao, Frances Shepherd, Mikael Johansson, Kjell Grankvist, Albert Rosenberger, Angela Risch, Thomas Muley, Judith Manz, Irene Brüske, Penella Woll, Fiona Taylor, Angela Cox, Gary E. Goodman, Jennifer Doherty, Rosario Tumino, Antonia Trichopoulou, Kim Overvad, David C. Muller, Olle Melander, Jonas Manjer, Hans Brunnström, Michael W. Marcus, Michael P. A. Davies, Zhibin Hu, Juncheng Dai, Jin Hee Kim, Erik H. F. M. van der Heijden, Guillermo Fernandez-Tardon, Ana Fernandez-Somoano, Lynne Wilkens, Christopher Haiman, Walid Saliba, Anders Mellemgaard, Jakob S. Johansen, Natasha Leighl, Yonathan Brhane, Ruyang Zhang, Li Su, Nancy Diao, Yuanqing Ye, Angela C. Pesatori, Pier A. Bertazzi, Jian-Min Yuan, Yun-Chul Hong, Hongbing Shen, Angeline S. Andrew, Matthew B. Schabath, Stephen Lam, Aage Haugen, Philip Lazarus, Lambertus A. Kiemeney, John K. Field, M. Dawn Teare, Chu Chen, Gad Rennert, Adonina Tardon, William S. Bush, Melinda C. Aldrich, Heike Bickeböller, Demetrios Albanes, Loic Le Marchand, Stig E. Bojesen, Geoffrey Liu, Mattias Johansson, Neil Caporaso, David C. Christiani, Robert Carreras-Torres, Xuchen Zong, James McKay, Xifeng Wu, Rayjean J. Hung, Olga Gorlova, Younghun Han, Mariella de Biasi, Ivan Gorlov, Yafang Li, Maxime Lamontagne, Philippe Joubert, David Qian, Xiangjun Xiao, Jiang Gui, Maria Teresa Landi, Yohan Bossé, Xuemei Ji, Nature Communications, 2018, 10.1038/s41467-018-05074-y
  • Polygenic Risk Score for Coronary Artery Disease Improves the Prediction of Early-Onset Myocardial Infarction and Mortality in Men, Sébastien Thériault, Benoit J. Arsenault, Yohan Bossé, Patrick Mathieu, Christian Couture, Zhonglin Li, Nicolas Perrot, Aida Eslami, Hasanga D. Manikpurage, Circulation: Genomic and Precision Medicine, 2021, 10.1161/CIRCGEN.121.003452
  • A transcriptome-wide association study identifies PALMD as a susceptibility gene for calcific aortic valve stenosis, Yohan Bossé, Patrick Mathieu, Philippe Pibarot, François Dagenais, Romain Capoulade, Marie-Annick Clavel, David Messika-Zeitoun, Maxime Lamontagne, Nathalie Gaudreault, Sébastien Thériault, 2017, 10.1101/184945
  • Protein-altering germline mutations implicate novel genes related to lung cancer development, Christopher I. Amos, James D. McKay, Paul Brennan, Stephen Chanock, Hermann Brenner, Sanjay Shete, María Soler Artigas, Wim Timens, Ma’en Obeidat, David C. Nickle, Victoria Stevens, John McLaughlin, Richard Houlston, Michael F. Berger, Barry S. Taylor, Zsofia K. Stadler, Charles M. Rudin, Mark E. Robson, David B. Solit, Matthew D. Hellmann, Chaitanya Bandlamudi, Preethi Srinivasan, Kenneth Offit, Lesley M. Butler, Vidar Skaug, Per Bakke, David Zaridze, Beata Swiatkowska, Ghislaine Scelo, Tadeusz M. Orlowski, Simona Ognjanovic, Anush Mukeria, Jolanta Lissowska, Milica Kontic, Vladimir Janout, Ivana Holcatova, Ciprian Bolca, Eric B. Haura, Susanne M. Arnold, Ming-Sound Tsao, Frances Shepherd, Mikael Johansson, Kjell Grankvist, Albert Rosenberger, Angela Risch, Thomas Muley, Erich Wichmann, Penella Woll, Fiona Taylor, Angela Cox, Gary E. Goodman, Rosario Tumino, Antonia Trichopoulou, Kim Overvad, David C. Muller, Olle Melander, Jonas Manjer, Hans Brunnström, Michael W. Marcus, Michael P. A. Davies, Jin Hee Kim, Erik H. F. M. van der Heijden, Guillermo Fernandez-Tardon, Ana Fernandez-Somoano, Lynne Wilkens, Christopher Haiman, Walid Saliba, Anders Mellemgaard, Jakob S. Johansen, Natasha Leighl, Ruyang Zhang, Lei Song, Li Su, Nancy Diao, Angela C. Pesatori, Pier A. Bertazzi, Angeline S. Andrew, Matthew B. Schabath, Stephen Lam, Shan Zienolddiny, Philip Lazarus, Lambertus FA. Kiemeney, John K. Field, Konstantin H. Dragnev, Jinyoung Byun, Chu Chen, Gad Rennert, Adonina Tardon, William S. Bush, Melinda C. Aldrich, Heike Bickeböller, Demetrios Albanes, Loic Le Marchand, Stig E. Bojesen, Geoffrey Liu, Mattias Johansson, Neil Caporaso, David C. Christiani, Robert Carreras-Torres, Yonathan Brhane, Rayjean J. Hung, Olga Gorlova, Younghun Han, Xiangjun Xiao, Ivan Gorlov, Dakai Zhu, Philippe Joubert, Yohan Bosse, Maria Teresa Landi, Semanti Mukherjee, Xuemei Ji, Nature Communications, 2020, 10.1038/s41467-020-15905-6
  • Novel Genetic Susceptibility Loci for FEV1 in the Context of Occupational Exposure in Never-Smokers, H. Marike Boezen, Dirkje S. Postma, Ivana Nedeljkovic, Hans Kromhout, Yohan Bossé, Wim Timens, Diana A. van der Plaat, Alen Faiz, Judith M. Vonk, Kim de Jong, American Journal of Respiratory and Critical Care Medicine, 2016, 10.1164/rccm.201603-0646LE
  • Variants associated with HHIP expression have sex-differential effects on lung function [version 1; peer review: 2 approved], Louise V. Wain, Martin D. Tobin, Ian P. Hall, Caroline Hayward, Ben M. Brumpton, David P. Strachan, John Henderson, Henry Völzke, Nicholas J. Wareham, Nicole Probst-Hensch, Tim Spector, James F. Wilson, Debbie Jarvis, Ian J. Deary, Veronique Vitart, Terho Lehtimäki, Jaakko Kaprio, Craig E. Pennell, Peter D. Sly, Graham L. Hall, Olli T. Raitakari, Mika Kähönen, Kirsi Pietiläinen, Taina Rantanen, Igor Rudan, Thomas Meitinger, Konstantin Strauch, Stefan Karrasch, John M. Starr, Ozren Polasek, Mangino Massimo, Karina Patasova, Peter K. Joshi, Lucija Klaric, Nicola Pirastu, Beate Stubbe, Ralf Ewert, Cristen Willer, Kristian Hveem, Arnulf Langhammer, Sue Ring, David M. Evans, Blair H. Smith, Sandosh Padmanabhan, David Porteous, Archie Campbell, Ke Hao, Don D. Sin, Maarten Van den Berge, Yohan Bossé, Claudia Langenberg, Cosetta Minelli, Dirk Keidel, Rachel E. Foong, Teemu Palviainen, Leo-Pekka Lyytikäinen, Carol A. Wang, Sarah E. Harris, Claudia Flexeder, Laura Portas, Thibaud S. Boutin, Pirro Hysi, Sebastian May-Wilson, Medea Imboden, Stefan Weiss, Raquel Granell, Marta R. Moksnes, Anne Richmond, Jian'an Luan, Catherine John, Anna L. Guyatt, Nick Shrine, Carl Melbourne, Ma'en Obeidat, Katherine A. Fawcett, 2020, 10.12688/wellcomeopenres.15846.1
  • Sex-Specific Associations of Genetically-Predicted Circulating Lipoprotein(a) and Hepatic LPA Gene Expression Levels with Cardiovascular Outcomes: Mendelian Randomization and Observational Analyses, Benoit J. Arsenault, S. Matthijs Boekholdt, Sébastien Thériault, Marie-Annick Clavel, Patrick Mathieu, Erik S.G. Stroes, Philippe Pibarot, Yohan Bossé, Nicholas J. Wareham, Christian Couture, Raphaëlle Bourgeois, Nicolas Perrot, Hasanga Manikpurage, Yannick Kaiser, Jakie Guertin, Circulation: Genomic and Precision Medicine, 2021, 10.1161/CIRCGEN.120.003271
  • Integrative Genomics of Emphysema-Associated Genes Reveals Potential Disease Biomarkers, Peter D. Paré, Don D. Sin, James C. Hogg, Alvar Agusti, Rosa Faner, Stephen Lam, Wan Lam, Tillie-Louise Hackett, Avrum Spira, Stephen Rennard, Bruce E. Miller, Bruce McManus, Raymond T. Ng, Zsuzsanna Hollander, Casey P. Shannon, Marc A. Sze, Wim Timens, Dirkje S. Postma, Ke Hao, David C. Nickle, Philippe Joubert, Yohan Bossé, Xuan Li, Nick Fishbane, Yunlong Nie, Ma’en Obeidat, American Journal of Respiratory Cell and Molecular Biology, 2017, 10.1165/rcmb.2016-0284OC
  • Meta-analysis of exome array data identifies six novel genetic loci for lung function [version 1; referees: awaiting peer review], Stephanie J. London, Martin D. Tobin, Ian P. Hall, Alanna C. Morrison, Josee Dupuis, David P. Strachan, Terho Lehtimäki, Eleftheria Zeggini, Sven Gläser, Nicole Probst-Hensch, M. Arfan Ikram, Andrew P. Morris, Ulf Gyllensten, Renée de Mutsert, R. Graham Barr, Ian Deary, Shona Kerr, Caroline Hayward, Konstantin Strauch, Henrik Vestergaard, James G. Wilson, Oluf Pederson, Tamara B. Harris, Jaakko Kaprio, George T. O'Connor, Kent D. Taylor, Don D. Sin, Sina A. Gharib, Kari E. North, Vilmundur Gudnason, Olli T. Raitakari, Stefan Weiss, André G. Uitterlinden, Erik Ingelsson, Åsa Johansson, Dennis O. Mook-Kanamori, Stephen Rich, John M. Starr, Ozren Polasek, Archie Campbell, Holger Schulz, Torben Hansen, Charlotta Pisinger, Tea Skaaby, Kurt Lohman, Stephen B. Kritchevsky, Taina Rantanen, Ke Hao, Susan R. Heckbert, Bruce M. Psaty, Annah B. Wyss, Mika Kähönen, Understanding Society Scientific Group, Beate Stubbe, Ashish Kumar, Guy G. Brusselle, Lars Lind, Stefan Enroth, Tobias N. Bonten, Josyf C. Mychaleckyj, Kristin M. Burkart, Gail Davies, Blair H. Smith, Jennifer E. Huffman, Stefan Karrasch, Rajesh Rawal, Leslie A. Lange, Allan Linneberg, Johanne M. Justesen, Jette Bork-Jensen, Yongmei Liu, Wenbo Tang, Anu Loukola, Aldi Kraja, Wim Timens, Yohan Bossé, Jennifer A. Brody, Colleen M. Sitlani, Nora Franceschini, Gudny Eiriksdottir, Leo-Pekka Lyytikäinen, Bram Prins, Alexander Teumer, Medea Imboden, Lies Lahousse, Anubha Mahajan, Allan Lind-Thomsen, Ruifang Li-Gao, Tess D. Pottinger, Ani Manichaikul, Sarah E. Harris, Jonathan Marten, Elisabeth Altmaier, Jin Li, Niels Grarup, Tarunveer S. Ahluwalia, Patricia A. Cassano, David J. Porteous, Beenish Qaiser, Wei Gao, Michael A. Province, Ma'en Obeidat, Traci M. Bartz, Megan L. Grove, Albert V. Smith, Louise V. Wain, Jeanne C. Latourelle, Victoria E. Jackson, 2018, 10.12688/wellcomeopenres.12583.1
  • A Simplified Version of the IASLC Grading System for Invasive Pulmonary Adenocarcinomas With Improved Prognosis Discrimination, Philippe Joubert, Patrice Desmeules, Pierre O. Fiset, David Joubert, Sylvain Pagé, Sylvain Trahan, Christian Couture, Michèle Orain, Wajd A. Althakfi, Andréanne Gagné, Yohan Bossé, American Journal of Surgical Pathology, 2023, 10.1097/PAS.0000000000002040
  • Granularity of SERPINA1 alleles by DNA sequencing in CanCOLD, Yohan Bossé, Jean Bourbeau, Wan Tan, François Maltais, Miranda Kirby, Cyndi Henry, Pei Zhi Li, Sébastien Thériault, Nathalie Gaudreault, Nisha Gupta, European Respiratory Journal, 2020, 10.1183/13993003.00958-2020
  • Reply to Polverino: Cigarette Smoking and COVID-19: A Complex Interaction, Christopher I. Amos, Farrah Kheradmand, Feifei Xiao, Yohan Bossé, Guoshuai Cai, American Journal of Respiratory and Critical Care Medicine, 2020, 10.1164/rccm.202005-1807LE
  • Tumor-based gene expression biomarkers to predict survival following curative intent resection for stage I lung adenocarcinoma, Yohan Bossé, Philippe Joubert, Michel Laviolette, Catherine Labbé, Paula A. Ugalde, Cyndi Henry, Nathalie Gaudreault, Alisson Clemenceau, PLOS ONE, 2018, 10.1371/journal.pone.0207513
  • Single-cell expression and Mendelian randomization analyses identify blood genes associated with lifespan and chronic diseases, Patrick Mathieu, Benoit J. Arsenault, Sébastien Thériault, Yohan Bossé, Deborah Argaud, Zhonglin Li, Marie-Chloé Boulanger, Valentin Bon-Baret, Arnaud Chignon, Communications Biology, 2020, 10.1038/s42003-020-0937-x
  • Meta-analysis of exome array data identifies six novel genetic loci for lung function [version 3; referees: 2 approved], Stephanie J. London, Martin D. Tobin, Ian P. Hall, Alanna C. Morrison, Josée Dupuis, David P. Strachan, Terho Lehtimäki, Eleftheria Zeggini, Sven Gläser, Nicole Probst-Hensch, M. Arfan Ikram, Andrew P. Morris, Ulf Gyllensten, Renée de Mutsert, R. Graham Barr, Ian J. Deary, Shona Kerr, Caroline Hayward, Konstantin Strauch, James G. Wilson, Henrik Vestergaard, Oluf Pederson, Tamara B. Harris, Jaakko Kaprio, George T. O'Connor, Kent D. Taylor, Don D. Sin, Sina A. Gharib, Kari E. North, Vilmundur Gudnason, Olli T. Raitakari, Stefan Weiss, André G. Uitterlinden, Erik Ingelsson, Åsa Johansson, Dennis O. Mook-Kanamori, Stephen S. Rich, John M. Starr, Archie Campbell, Ozren Polasek, Holger Schulz, Torben Hansen, Charlotta Pisinger, Tea Skaaby, Kurt Lohman, Stephen B. Kritchevsky, Taina Rantanen, Ke Hao, Susan R. Heckbert, Bruce M. Psaty, Annah B. Wyss, Mika Kähönen, Understanding Society Scientific Group, Beate Stubbe, Ashish Kumar, Guy G. Brusselle, Lars Lind, Stefan Enroth, Tobias N. Bonten, Josyf C. Mychaleckyj, Kristin M. Burkart, Gail Davies, Blair H. Smith, Jennifer E. Huffman, Stefan Karrasch, Rajesh Rawal, Leslie A. Lange, Allan Linneberg, Johanne M. Justesen, Jette Bork-Jensen, Yongmei Liu, Wenbo Tang, Anu Loukola, Aldi Kraja, Wim Timens, Yohan Bossé, Jennifer A. Brody, Colleen M. Sitlani, Nora Franceschini, Gudny Eiriksdottir, Leo-Pekka Lyytikäinen, Bram Prins, Alexander Teumer, Medea Imboden, Lies Lahousse, Anubha Mahajan, Allan Lind-Thomsen, Ruifang Li-Gao, Tess D. Pottinger, Ani Manichaikul, Sarah E. Harris, Jonathan Marten, Elisabeth Altmaier, Jin Li, Niels Grarup, Tarunveer S. Ahluwalia, Patricia A. Cassano, David J. Porteous, Beenish Qaiser, Wei Gao, Michael A. Province, Ma'en Obeidat, Traci M. Bartz, Megan L. Grove, Albert V. Smith, Louise V. Wain, Jeanne C. Latourelle, Victoria E. Jackson, 2018, 10.12688/wellcomeopenres.12583.3
  • Integrative Analysis of the Blood Proteome by Mendelian Randomization Reveals Regulatory Networks in Calcific Aortic Valve Disease, Patrick Mathieu, Yohan Bossé, Benoit Arsenault, Sébastien Thériault, Anne Rufiange, Samuel Mathieu, Valentine Duclos, Louis-Hippolyte Minvielle Moncla, Mewen Briend, 2023, 10.1101/2023.07.26.23293222
  • Clinical Experience with SERPINA1 DNA Sequencing to Detect Alpha-1 Antitrypsin Deficiency, Yohan Bossé, Sébastien Thériault, Christine Racine, Nathalie Gaudreault, François Maltais, Annals of the American Thoracic Society, 2018, 10.1513/AnnalsATS.201708-694RL
  • Meta-analysis of exome array data identifies six novel genetic loci for lung function [version 2; referees: 2 approved], Stephanie J. London, Martin D. Tobin, Ian P. Hall, Alanna C. Morrison, Josée Dupuis, David P. Strachan, Terho Lehtimäki, Eleftheria Zeggini, Sven Gläser, Nicole Probst-Hensch, M. Arfan Ikram, Andrew P. Morris, Ulf Gyllensten, Renée de Mutsert, R. Graham Barr, Ian J. Deary, Shona Kerr, Caroline Hayward, Konstantin Strauch, James G. Wilson, Henrik Vestergaard, Oluf Pederson, Tamara B. Harris, Jaakko Kaprio, George T. O'Connor, Kent D. Taylor, Don D. Sin, Sina A. Gharib, Kari E. North, Vilmundur Gudnason, Olli T. Raitakari, Stefan Weiss, André G. Uitterlinden, Erik Ingelsson, Åsa Johansson, Dennis O. Mook-Kanamori, Stephen S. Rich, John M. Starr, Archie Campbell, Ozren Polasek, Holger Schulz, Torben Hansen, Charlotta Pisinger, Tea Skaaby, Kurt Lohman, Stephen B. Kritchevsky, Taina Rantanen, Ke Hao, Susan R. Heckbert, Bruce M. Psaty, Annah B. Wyss, Mika Kähönen, Understanding Society Scientific Group, Beate Stubbe, Ashish Kumar, Guy G. Brusselle, Lars Lind, Stefan Enroth, Tobias N. Bonten, Josyf C. Mychaleckyj, Kristin M. Burkart, Gail Davies, Blair H. Smith, Jennifer E. Huffman, Stefan Karrasch, Rajesh Rawal, Leslie A. Lange, Allan Linneberg, Johanne M. Justesen, Jette Bork-Jensen, Yongmei Liu, Wenbo Tang, Anu Loukola, Aldi Kraja, Wim Timens, Yohan Bossé, Jennifer A. Brody, Colleen M. Sitlani, Nora Franceschini, Gudny Eiriksdottir, Leo-Pekka Lyytikäinen, Bram Prins, Alexander Teumer, Medea Imboden, Lies Lahousse, Anubha Mahajan, Allan Lind-Thomsen, Ruifang Li-Gao, Tess D. Pottinger, Ani Manichaikul, Sarah E. Harris, Jonathan Marten, Elisabeth Altmaier, Jin Li, Niels Grarup, Tarunveer S. Ahluwalia, Patricia A. Cassano, David J. Porteous, Beenish Qaiser, Wei Gao, Michael A. Province, Ma'en Obeidat, Traci M. Bartz, Megan L. Grove, Albert V. Smith, Louise V. Wain, Jeanne C. Latourelle, Victoria E. Jackson, 2018, 10.12688/wellcomeopenres.12583.2
  • Prognostic value of complex glandular patterns in invasive pulmonary adenocarcinomas, Philippe Joubert, Patrice Desmeules, Pierre Olivier Fiset, Michèle Orain, Wajd Althakfi, Andréanne Gagné, Yohan Bossé, Human Pathology, 2022, 10.1016/j.humpath.2022.07.007
  • A Test to Comprehensively Capture the Known Genetic Component of Familial Pulmonary Fibrosis, Yohan Bossé, Geneviève Dion, Sébastien Renaut, Zhonglin Li, Dominique K Boudreau, Victoria Saavedra Armero, Nathalie Gaudreault, Élody Tremblay, Judith Villeneuve, American Journal of Respiratory Cell and Molecular Biology, 2024, 10.1165/rcmb.2024-0009MA

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Mona Patoughi - Doctorat - En cours
  • Veronique Boumtje - Doctorat - En cours
  • Mozart Nerva Deneus - Maîtrise avec mémoire - En cours
  • Ran Xu - Doctorat - En cours
  • Samuel Mathieu - Maîtrise avec mémoire - En cours
  • Maxime Lamontagne - Maîtrise avec mémoire - 2013/01
  • Jean-Christophe Bérubé - Maîtrise avec mémoire - 2014/05
  • Sandra Milena Guauque - Doctorat - 2015/09
  • Alisson Clemenceau - Maîtrise avec mémoire - 2017/09
  • Nicolas Perrot - Doctorat - 2020/05
  • Louis-Jacques Ruel - Maîtrise avec mémoire - 2024/01

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