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Yohan Bossé

Professeur titulaire

Yohan Bossé
Yohan.Bosse@criucpq.ulaval.ca
Centre de recherche sur le cancer
Groupe de recherche en santé respiratoire
Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Bioinformatique / données massives (big data)
Oncologie
Santé cardiovasculaire, respiratoire et métabolisme

Domaines et intérêts de recherche du (de la) professeur(e) :

Cancer
  • Cancer du poumon
Génétique humaine
  • Génomique
  • Génétique de traits complexes
  • Gènes de susceptibilité
  • Dépistage génétique des maladies
  • Micropuces d'ADN et d'ARN
Santé circulatoire et respiratoire
  • Maladie pulmonaire obstructive chronique
  • Asthme

Projets de recherche

  • Programme VISION - Fonds de recherche du Québec - Santé - Tremplin, co-chercheur - 2022-11-15 au 2026-03-31
  • Canada Research Chair in Genomics of Heart and Lung Diseases - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2020-07-01 au 2025-06-30
  • Air pollution, climate and COPD: acute and long-term impacts in Canadian populations - Instituts de recherche en santé du Canada - Subvention Projet, McGill University, co-chercheur - 2021-04-01 au 2025-03-31
  • Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
  • A transcriptome- and proteome-wide association study of non-alcoholic fatty liver disease - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2021-10-01 au 2024-09-30
  • Deciphering the role of PTPN6/SHP-1 and its mutant PTPN6/SHP-1Ala455Thr in the development of pulmonary emphysema - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2019-10-01 au 2024-09-30
  • Integrative genomics and functional analyses to uncover the molecular mechanisms involved in bicuspid aortic valve disease - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2019-04-01 au 2024-03-31
  • Analyse statistique des liens entre blocs de variables de format mixte. Applications en épidémiologie, génomique et sécurité sanitaire. - Fonds de recherche du Québec - Nature et technologies - Programme Samuel-De Champlain, co-chercheur - 2022-04-01 au 2024-03-31
  • Elucidating the role of lipoprotein(a) in calcific aortic valve stenosis using novel proteomic and imaging approaches - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2019-10-01 au 2023-09-30
  • A genome-wide association study of dysanapsis - Instituts de recherche en santé du Canada - Subvention Projet, McGill University, co-chercheur - 2020-04-01 au 2023-03-31
  • Finding the molecular drivers of calcific aortic valve stenosis - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2018-10-01 au 2023-03-31
  • Functional and clinical characterization of PALMD calcific aortic valve stenosis risk locus - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2018-10-01 au 2023-03-31
  • Liking clinical, research and imaging data in lung cancer: towards FAIR and AI-ready datasets - Société canadienne du cancer - Subventions de transformation de données sur le cancer, co-chercheur - 2022-03-15 au 2023-03-14
  • The IUCPQ-UL cases series of patients with idiopathic pulmonary fibrosis: A resource for clinical and genetic research - Fondation de l'Institut universitaire de cardiologie et de pneumologie de Québec, chercheur principal - 2022-01-01 au 2022-12-31
  • Copy Number Variation and Lung Cancer: Disease Risk and Mechanisms - National Institute of Health (USA) - R21 Exploratory Research Grant (PA-17-243), University of South Carolina , co-chercheur - 2020-09-01 au 2022-08-30
  • Identification of novel therapeutic targets for calcific aortic valve stenosis using integrative genomics - Fondation des maladies du coeur et de l'AVC du Canada - Subventions de recherche, co-chercheur - 2019-07-01 au 2022-06-30
  • Multi-omic approach to sex-differences in aortic stenosis - Fondation des maladies du coeur et de l'AVC du Canada, co-chercheur - 2021-07-01 au 2022-06-30
  • Genomic predictors of smoking and lung cancer risk - National Institute of Health (USA) - Subvention de recherche, Geisel School of Medicine at Dartmouth, co-chercheur - 2017-08-01 au 2022-05-31
  • Prognostic biomarkers from single-cell map of resected stage I lung adenocarcinoma - Fondation de l'Institut universitaire de cardiologie et de pneumologie de Québec, chercheur principal - 2021-01-01 au 2021-12-31
  • The role of autotaxin and lysophosphatidic acid in the development of calcific aortic valve disease - Instituts de recherche en santé du Canada - Volet Projet: Concours pilotes, co-chercheur - 2016-07-01 au 2021-06-30
  • Stage d'été « Carrière été » - Emploi et Développement Social Canada (EDSC), chercheur principal - 2021-05-03 au 2021-06-25
  • Pairwise genetic interaction analysis among oncogenesis related genes in lung cancer. - National Institute of Health (USA) - Subvention de recherche, Baylor College of Medicine, co-chercheur - 2019-06-01 au 2021-05-31
  • A new form of hereditary emphysema due to mutation in the PTPN6 gene - Phase 2 - Fondation de l'Université Laval, co-chercheur - 2019-12-01 au 2020-11-30
  • L'architecture génétique du rétrécissement valvulaire aortique chez les populations d'ascendance eutropéene et asiatique - Fonds de recherche du Québec - Santé - Recherches sur les maladies cardiovasculaires NSFC - FRQS, chercheur principal - 2018-04-01 au 2020-03-31

Publications

  • Calcific aortic valve disease: mechanisms, prevention and treatment, Louis-Hippolyte Minvielle Moncla, Mewen Briend, Yohan Bossé, Patrick Mathieu, Nature Reviews Cardiology, 2023, 10.1038/s41569-023-00845-7
  • The journey towards identification of actionable molecular pathways in calcific aortic valve stenosis, Sébastien Thériault, Patrick Mathieu, Yohan Bossé, 2023, 10.1093/eurheartj/ehad134
  • Prognostic value of complex glandular patterns in invasive pulmonary adenocarcinomas, Yohan Bossé, Andréanne Gagné, Wajd Althakfi, Michèle Orain, Pierre Olivier Fiset, Patrice Desmeules, Philippe Joubert, Human Pathology, 2022, 10.1016/j.humpath.2022.07.007
  • The Null Q0Ourém Variant within a Copy-Neutral Loss-of-Heterozygosity Event Causing Alpha-1 Antitrypsin Deficiency, Nathalie Gaudreault, Claudia Blouin, Annie Haillot, Julie Milot, François Maltais, Yohan Bossé, American Journal of Respiratory Cell and Molecular Biology, 2022, 10.1165/rcmb.2021-0564LE
  • Genome-wide chromatin contacts of super-enhancer-associated lncRNA identify LINC01013 as a regulator of fibrosis in the aortic valve, Arnaud Chignon, Déborah Argaud, Marie-Chloé Boulanger, Ghada Mkannez, Valentin Bon-Baret, Zhonglin Li, Sébastien Thériault, Yohan Bossé, Patrick Mathieu, PLOS Genetics, 2022, 10.1371/journal.pgen.1010010
  • Polygenic Risk Score for Coronary Artery Disease Improves the Prediction of Early-Onset Myocardial Infarction and Mortality in Men, Hasanga D. Manikpurage, Aida Eslami, Nicolas Perrot, Zhonglin Li, Christian Couture, Patrick Mathieu, Yohan Bossé, Benoit J. Arsenault, Sébastien Thériault, Circulation: Genomic and Precision Medicine, 2021, 10.1161/CIRCGEN.121.003452
  • SARS-CoV-2 Impairs Dendritic Cells and Regulates DC-SIGN Gene Expression in Tissues, Guoshuai Cai, Mulong Du, Yohan Bossé, Helmut Albrecht, Fei Qin, Xizhi Luo, Xiao Michelle Androulakis, Chao Cheng, Mitzi Nagarkatti, Prakash Nagarkatti, David C. Christiani, Michael L. Whitfield, Christopher I. Amos, Feifei Xiao, International Journal of Molecular Sciences, 2021, 10.3390/ijms22179228
  • Sex-Specific Associations of Genetically-Predicted Circulating Lipoprotein(a) and Hepatic LPA Gene Expression Levels with Cardiovascular Outcomes: Mendelian Randomization and Observational Analyses, Jakie Guertin, Yannick Kaiser, Hasanga Manikpurage, Nicolas Perrot, Raphaëlle Bourgeois, Christian Couture, Nicholas J. Wareham, Yohan Bossé, Philippe Pibarot, Erik S.G. Stroes, Patrick Mathieu, Marie-Annick Clavel, Sébastien Thériault, S. Matthijs Boekholdt, Benoit J. Arsenault, Circulation: Genomic and Precision Medicine, 2021, 10.1161/CIRCGEN.120.003271
  • Genome-wide interaction analysis identified low-frequency variants with sex disparity in lung cancer risk, Yafang Li, Xiangjun Xiao, Jianrong Li, Jinyoung Byun, Chao Cheng, Yohan Bossé, James McKay, Demetrius Albanes, Stephen Lam, Adonina Tardon, Chu Chen, Stig Bojesen, Maria Landi, Mattias Johansson, Angela Risch, Heike Bickeböller, Erich Wichmann, David Christiani, Gad Rennert, Susanne Arnold, Gary Goodman, John Field, Sanjay Shete, Loic Le Marchand, Olle Melander, Hans Brunnström, Geoffrey Liu, Rayjean Hung, Angeline Andrew, Lambertus Kiemeney, Hongbing Shen, Ryan Sun, Shanbeh Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil Caporaso, Dawn Teare, Yun-Chul Hong, Michael Davies, Philip Lazarus, Matthew Schabath, Melinda Aldrich, Ann Schwartz, Ivan Gorlov, Kristen Purrington, Ping Yang, Younghun Han, Joan Bailey-Wilson, Yanhong Liu, Susan Pinney, Diptasri Mandal, James Willey, Colette Gaba, Paul Brennan, Christopher Amos, 2021, 10.21203/rs.3.rs-647012/v1
  • A Polygenic Risk Score for Coronary Artery Disease Improves the Prediction of Early-Onset Myocardial Infarction and Mortality in Men, Hasanga D. Manikpurage, Aida Eslami, Nicolas Perrot, Zhonglin Li, Christian Couture, Patrick Mathieu, Yohan Bossé, Benoit J. Arsenault, Sébastien Thériault, 2021, 10.1101/2021.04.25.21256083
  • System Genetics Including Causal Inference Identify Immune Targets for Coronary Artery Disease and the Lifespan, Valentin Bon-Baret, Arnaud Chignon, Marie-Chloé Boulanger, Zhonglin Li, Deborah Argaud, Benoit J. Arsenault, Sébastien Thériault, Yohan Bossé, Patrick Mathieu, Circulation: Genomic and Precision Medicine, 2021, 10.1161/CIRCGEN.120.003196
  • Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers, Corina Lesseur, Aida Ferreiro-Iglesias, James D. McKay, Yohan Bossé, Mattias Johansson, Valerie Gaborieau, Maria Teresa Landi, David C. Christiani, Neil C. Caporaso, Stig E. Bojesen, Christopher I. Amos, Sanjay Shete, Geoffrey Liu, Gadi Rennert, Demetrius Albanes, Melinda C. Aldrich, Adonina Tardon, Chu Chen, Liloglou Triantafillos, John K. Field, Marion Dawn Teare, Lambertus A. Kiemeney, Brenda Diergaarde, Robert L. Ferris, Shanbeh Zienolddiny, Stephen Lam, Andrew F. Olshan, Mark C. Weissler, Martin Lacko, Angela Risch, Heike Bickeböller, Andy R. Ness, Steve Thomas, Loic Le Marchand, Matthew B. Schabath, Victor Wünsch-Filho, Eloiza H. Tajara, Angeline S. Andrew, Gary M. Clifford, Philip Lazarus, Kjell Grankvist, Mikael Johansson, Susanne Arnold, Olle Melander, Hans Brunnström, Stefania Boccia, Gabriella Cadoni, Wim Timens, Ma’en Obeidat, Xiangjun Xiao, Richard S. Houlston, Rayjean J. Hung, Paul Brennan, PLOS Genetics, 2021, 10.1371/journal.pgen.1009254
  • Oxyphospholipids in Cardiovascular Calcification, Arnaud Chignon, Valentin Bon-Baret, Marie-Chloé Boulanger, Yohan Bossé, Patrick Mathieu, Arteriosclerosis, Thrombosis, and Vascular Biology, 2020, 10.1161/ATVBAHA.120.313790
  • Electronic Health Record-Based Genome-Wide Meta-Analysis and Mendelian Randomization Identify Metabolic and Phenotypic Consequences of Non-Alcoholic Fatty Liver Disease, Nooshin Ghodsian, Erik Abner, Émilie Gobeil, Nele Taba, Alexis St-Amand, Nicolas Perrot, Christian Couture, Patricia Mitchell, Yohan Bossé, Patrick Mathieu, Marie-Claude Vohl, Sébastien Thériault, André Tchernof, Tõnu Esko, Benoit Arsenault, 2020, 10.21203/rs.3.rs-97977/v1
  • Granularity of SERPINA1 alleles by DNA sequencing in CanCOLD, Nisha Gupta, Nathalie Gaudreault, Sébastien Thériault, Pei Zhi Li, Cyndi Henry, Miranda Kirby, François Maltais, Wan Tan, Jean Bourbeau, Yohan Bossé, European Respiratory Journal, 2020, 10.1183/13993003.00958-2020
  • Transcriptomic data helps refining classification of pulmonary carcinoid tumors with increased mitotic counts, Olga Sazonova, Venkata Manem, Michèle Orain, Babak Khoshkrood-Mansoori, Nathalie Gaudreault, Patrice Desmeules, Yohan Bossé, Philippe Joubert, Modern Pathology, 2020, 10.1038/s41379-020-0538-8
  • Phenome-wide analyses establish a specific association between aortic valve PALMD expression and calcific aortic valve stenosis, Zhonglin Li, Nathalie Gaudreault, Benoit J. Arsenault, Patrick Mathieu, Yohan Bossé, Sébastien Thériault, Communications Biology, 2020, 10.1038/s42003-020-01210-x
  • Reply to Polverino: Cigarette Smoking and COVID-19: A Complex Interaction, Guoshuai Cai, Yohan Bossé, Feifei Xiao, Farrah Kheradmand, Christopher I. Amos, American Journal of Respiratory and Critical Care Medicine, 2020, 10.1164/rccm.202005-1807LE
  • A Trans-Omic Mendelian Randomization Study of Parental Lifespan Uncovers Novel Aging Biology and Drug Candidates for Human Healthspan Extension, Nicolas Perrot, William Pelletier, Jerome Bourgeault, Christian Couture, Zhonglin Li, Patricia Mitchell, Nooshin Ghodsian, Yohan Bosse, Sebastien Theriault, Patrick Mathieu, Benoit J Arsenault, 2020, 10.1101/2020.07.06.20147520
  • Tobacco Smoking Increases the Lung Gene Expression of ACE2, the Receptor of SARS-CoV-2, Guoshuai Cai, Yohan Bossé, Feifei Xiao, Farrah Kheradmand, Christopher I. Amos, American Journal of Respiratory and Critical Care Medicine, 2020, 10.1164/rccm.202003-0693LE
  • Variants associated with HHIP expression have sex-differential effects on lung function [version 1; peer review: 2 approved], Katherine A. Fawcett, Ma'en Obeidat, Carl Melbourne, Nick Shrine, Anna L. Guyatt, Catherine John, Jian'an Luan, Anne Richmond, Marta R. Moksnes, Raquel Granell, Stefan Weiss, Medea Imboden, Sebastian May-Wilson, Pirro Hysi, Thibaud S. Boutin, Laura Portas, Claudia Flexeder, Sarah E. Harris, Carol A. Wang, Leo-Pekka Lyytikäinen, Teemu Palviainen, Rachel E. Foong, Dirk Keidel, Cosetta Minelli, Claudia Langenberg, Yohan Bossé, Maarten Van den Berge, Don D. Sin, Ke Hao, Archie Campbell, David Porteous, Sandosh Padmanabhan, Blair H. Smith, David M. Evans, Sue Ring, Arnulf Langhammer, Kristian Hveem, Cristen Willer, Ralf Ewert, Beate Stubbe, Nicola Pirastu, Lucija Klaric, Peter K. Joshi, Karina Patasova, Mangino Massimo, Ozren Polasek, John M. Starr, Stefan Karrasch, Konstantin Strauch, Thomas Meitinger, Igor Rudan, Taina Rantanen, Kirsi Pietiläinen, Mika Kähönen, Olli T. Raitakari, Graham L. Hall, Peter D. Sly, Craig E. Pennell, Jaakko Kaprio, Terho Lehtimäki, Veronique Vitart, Ian J. Deary, Debbie Jarvis, James F. Wilson, Tim Spector, Nicole Probst-Hensch, Nicholas J. Wareham, Henry Völzke, John Henderson, David P. Strachan, Ben M. Brumpton, Caroline Hayward, Ian P. Hall, Martin D. Tobin, Louise V. Wain, 2020, 10.12688/wellcomeopenres.15846.1
  • Protein-altering germline mutations implicate novel genes related to lung cancer development, Xuemei Ji, Semanti Mukherjee, Maria Teresa Landi, Yohan Bosse, Philippe Joubert, Dakai Zhu, Ivan Gorlov, Xiangjun Xiao, Younghun Han, Olga Gorlova, Rayjean J. Hung, Yonathan Brhane, Robert Carreras-Torres, David C. Christiani, Neil Caporaso, Mattias Johansson, Geoffrey Liu, Stig E. Bojesen, Loic Le Marchand, Demetrios Albanes, Heike Bickeböller, Melinda C. Aldrich, William S. Bush, Adonina Tardon, Gad Rennert, Chu Chen, Jinyoung Byun, Konstantin H. Dragnev, John K. Field, Lambertus FA. Kiemeney, Philip Lazarus, Shan Zienolddiny, Stephen Lam, Matthew B. Schabath, Angeline S. Andrew, Pier A. Bertazzi, Angela C. Pesatori, Nancy Diao, Li Su, Lei Song, Ruyang Zhang, Natasha Leighl, Jakob S. Johansen, Anders Mellemgaard, Walid Saliba, Christopher Haiman, Lynne Wilkens, Ana Fernandez-Somoano, Guillermo Fernandez-Tardon, Erik H. F. M. van der Heijden, Jin Hee Kim, Michael P. A. Davies, Michael W. Marcus, Hans Brunnström, Jonas Manjer, Olle Melander, David C. Muller, Kim Overvad, Antonia Trichopoulou, Rosario Tumino, Gary E. Goodman, Angela Cox, Fiona Taylor, Penella Woll, Erich Wichmann, Thomas Muley, Angela Risch, Albert Rosenberger, Kjell Grankvist, Mikael Johansson, Frances Shepherd, Ming-Sound Tsao, Susanne M. Arnold, Eric B. Haura, Ciprian Bolca, Ivana Holcatova, Vladimir Janout, Milica Kontic, Jolanta Lissowska, Anush Mukeria, Simona Ognjanovic, Tadeusz M. Orlowski, Ghislaine Scelo, Beata Swiatkowska, David Zaridze, Per Bakke, Vidar Skaug, Lesley M. Butler, Kenneth Offit, Preethi Srinivasan, Chaitanya Bandlamudi, Matthew D. Hellmann, David B. Solit, Mark E. Robson, Charles M. Rudin, Zsofia K. Stadler, Barry S. Taylor, Michael F. Berger, Richard Houlston, John McLaughlin, Victoria Stevens, David C. Nickle, Ma’en Obeidat, Wim Timens, María Soler Artigas, Sanjay Shete, Hermann Brenner, Stephen Chanock, Paul Brennan, James D. McKay, Christopher I. Amos, Nature Communications, 2020, 10.1038/s41467-020-15905-6
  • Single-cell expression and Mendelian randomization analyses identify blood genes associated with lifespan and chronic diseases, Arnaud Chignon, Valentin Bon-Baret, Marie-Chloé Boulanger, Zhonglin Li, Deborah Argaud, Yohan Bossé, Sébastien Thériault, Benoit J. Arsenault, Patrick Mathieu, Communications Biology, 2020, 10.1038/s42003-020-0937-x
  • Transcriptome‐wide association study reveals candidate causal genes for lung cancer, Yohan Bossé, Zhonglin Li, Jun Xia, Venkata Manem, Robert Carreras‐Torres, Aurélie Gabriel, Nathalie Gaudreault, Demetrius Albanes, Melinda C. Aldrich, Angeline Andrew, Susanne Arnold, Heike Bickeböller, Stig E. Bojesen, Paul Brennan, Hans Brunnstrom, Neil Caporaso, Chu Chen, David C. Christiani, John K. Field, Gary Goodman, Kjell Grankvist, Richard Houlston, Mattias Johansson, Mikael Johansson, Lambertus A. Kiemeney, Stephen Lam, Maria T. Landi, Philip Lazarus, Loic Le Marchand, Geoffrey Liu, Olle Melander, Gadi Rennert, Angela Risch, Susan M. Rosenberg, Matthew B. Schabath, Sanjay Shete, Zhuoyi Song, Victoria L. Stevens, Adonina Tardon, H‐Erich Wichmann, Penella Woll, Shan Zienolddiny, Ma'en Obeidat, Wim Timens, Rayjean J. Hung, Philippe Joubert, Christopher I. Amos, James D. McKay, International Journal of Cancer, 2020, 10.1002/ijc.32771
  • Whole Exome Sequencing of Highly Aggregated Lung Cancer Families Reveals Linked Loci for Increased Cancer Risk on Chromosomes 12q, 7p, and 4q, Anthony M. Musolf, Bilal A. Moiz, Haiming Sun, Claudio W. Pikielny, Yohan Bossé, Diptasri Mandal, Mariza de Andrade, Colette Gaba, Ping Yang, Yafang Li, Ming You, Ramaswamy Govindan, Richard K. Wilson, Elena Y. Kupert, Marshall W. Anderson, Ann G. Schwartz, Susan M. Pinney, Christopher I. Amos, Joan E. Bailey-Wilson, Cancer Epidemiology, Biomarkers & Prevention, 2020, 10.1158/1055-9965.EPI-19-0887
  • Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility, Linda Kachuri, Mattias Johansson, Sara R. Rashkin, Rebecca E. Graff, Yohan Bossé, Venkata Manem, Neil E. Caporaso, Maria Teresa Landi, David C. Christiani, Paolo Vineis, Geoffrey Liu, Ghislaine Scelo, David Zaridze, Sanjay S. Shete, Demetrius Albanes, Melinda C. Aldrich, Adonina Tardón, Gad Rennert, Chu Chen, Gary E. Goodman, Jennifer A. Doherty, Heike Bickeböller, John K. Field, Michael P. Davies, M. Dawn Teare, Lambertus A. Kiemeney, Stig E. Bojesen, Aage Haugen, Shanbeh Zienolddiny, Stephen Lam, Loïc Le Marchand, Iona Cheng, Matthew B. Schabath, Eric J. Duell, Angeline S. Andrew, Jonas Manjer, Philip Lazarus, Susanne Arnold, James D. McKay, Nima C. Emami, Matthew T. Warkentin, Yonathan Brhane, Ma’en Obeidat, Richard M. Martin, Caroline Relton, George Davey Smith, Philip C. Haycock, Christopher I. Amos, Paul Brennan, John S. Witte, Rayjean J. Hung, Nature Communications, 2020, 10.1038/s41467-019-13855-2
  • High FA2H and UGT8 transcript levels predict hydroxylated hexosylceramide accumulation in lung adenocarcinoma, Anne-Marie Lemay, Olivier Courtemanche, Timothy A. Couttas, Giuleta Jamsari, Andréanne Gagné, Yohan Bossé, Philippe Joubert, Anthony S. Don, David Marsolais, Journal of Lipid Research, 2019, 10.1194/jlr.M093955
  • A Mendelian randomization study of IL6 signaling in cardiovascular diseases, immune-related disorders and longevity, Mickael Rosa, Arnaud Chignon, Zhonglin Li, Marie-Chloé Boulanger, Benoit J. Arsenault, Yohan Bossé, Sébastien Thériault, Patrick Mathieu, npj Genomic Medicine, 2019, 10.1038/s41525-019-0097-4
  • Benefits and limitations of genome-wide association studies, Vivian Tam, Nikunj Patel, Michelle Turcotte, Yohan Bossé, Guillaume Paré, David Meyre, Nature Reviews Genetics, 2019, 10.1038/s41576-019-0127-1
  • Differential lung tissue gene expression in males and females: implications for the susceptibility to develop COPD, Maarten van den Berge, Corry-Anke Brandsma, Alen Faiz, Maaike de Vries, Senani N.H. Rathnayake, Peter D. Paré, Don D. Sin, Yohan Bossé, Michel Laviolette, David C. Nickle, Ke Hao, Ma'en Obeidat, Tommaso A. Dragani, Francesca Colombo, Wim Timens, Dirkje S. Postma, European Respiratory Journal, 2019, 10.1183/13993003.02567-2017
  • UCP1 expression–associated gene signatures of human epicardial adipose tissue, Kanta Chechi, Jinchu Vijay, Pierre Voisine, Patrick Mathieu, Yohan Bossé, Andre Tchernof, Elin Grundberg, Denis Richard, JCI Insight, 2019, 10.1172/jci.insight.123618
  • Tumor-based gene expression biomarkers to predict survival following curative intent resection for stage I lung adenocarcinoma, Alisson Clemenceau, Nathalie Gaudreault, Cyndi Henry, Paula A. Ugalde, Catherine Labbé, Michel Laviolette, Philippe Joubert, Yohan Bossé, PLOS ONE, 2018, 10.1371/journal.pone.0207513
  • Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk, Xuemei Ji, Yohan Bossé, Maria Teresa Landi, Jiang Gui, Xiangjun Xiao, David Qian, Philippe Joubert, Maxime Lamontagne, Yafang Li, Ivan Gorlov, Mariella de Biasi, Younghun Han, Olga Gorlova, Rayjean J. Hung, Xifeng Wu, James McKay, Xuchen Zong, Robert Carreras-Torres, David C. Christiani, Neil Caporaso, Mattias Johansson, Geoffrey Liu, Stig E. Bojesen, Loic Le Marchand, Demetrios Albanes, Heike Bickeböller, Melinda C. Aldrich, William S. Bush, Adonina Tardon, Gad Rennert, Chu Chen, M. Dawn Teare, John K. Field, Lambertus A. Kiemeney, Philip Lazarus, Aage Haugen, Stephen Lam, Matthew B. Schabath, Angeline S. Andrew, Hongbing Shen, Yun-Chul Hong, Jian-Min Yuan, Pier A. Bertazzi, Angela C. Pesatori, Yuanqing Ye, Nancy Diao, Li Su, Ruyang Zhang, Yonathan Brhane, Natasha Leighl, Jakob S. Johansen, Anders Mellemgaard, Walid Saliba, Christopher Haiman, Lynne Wilkens, Ana Fernandez-Somoano, Guillermo Fernandez-Tardon, Erik H. F. M. van der Heijden, Jin Hee Kim, Juncheng Dai, Zhibin Hu, Michael P. A. Davies, Michael W. Marcus, Hans Brunnström, Jonas Manjer, Olle Melander, David C. Muller, Kim Overvad, Antonia Trichopoulou, Rosario Tumino, Jennifer Doherty, Gary E. Goodman, Angela Cox, Fiona Taylor, Penella Woll, Irene Brüske, Judith Manz, Thomas Muley, Angela Risch, Albert Rosenberger, Kjell Grankvist, Mikael Johansson, Frances Shepherd, Ming-Sound Tsao, Susanne M. Arnold, Eric B. Haura, Ciprian Bolca, Ivana Holcatova, Vladimir Janout, Milica Kontic, Jolanta Lissowska, Anush Mukeria, Simona Ognjanovic, Tadeusz M. Orlowski, Ghislaine Scelo, Beata Swiatkowska, David Zaridze, Per Bakke, Vidar Skaug, Shanbeh Zienolddiny, Eric J. Duell, Lesley M. Butler, Woon-Puay Koh, Yu-Tang Gao, Richard Houlston, John McLaughlin, Victoria Stevens, David C. Nickle, Ma’en Obeidat, Wim Timens, Bin Zhu, Lei Song, María Soler Artigas, Martin D. Tobin, Louise V. Wain, Fangyi Gu, Jinyoung Byun, Ahsan Kamal, Dakai Zhu, Rachel F. Tyndale, Wei-Qi Wei, Stephen Chanock, Paul Brennan, Christopher I. Amos, Nature Communications, 2018, 10.1038/s41467-018-05074-y
  • The Overlap of Lung Tissue Transcriptome of Smoke Exposed Mice with Human Smoking and COPD, Ma’en Obeidat, Anna Dvorkin-Gheva, Xuan Li, Yohan Bossé, Corry-Anke Brandsma, David C. Nickle, Philip M. Hansbro, Rosa Faner, Alvar Agusti, Peter D. Paré, Martin R. Stampfli, Don D. Sin, Scientific Reports, 2018, 10.1038/s41598-018-30313-z
  • Meta-analysis of exome array data identifies six novel genetic loci for lung function [version 3; referees: 2 approved], Victoria E. Jackson, Jeanne C. Latourelle, Louise V. Wain, Albert V. Smith, Megan L. Grove, Traci M. Bartz, Ma'en Obeidat, Michael A. Province, Wei Gao, Beenish Qaiser, David J. Porteous, Patricia A. Cassano, Tarunveer S. Ahluwalia, Niels Grarup, Jin Li, Elisabeth Altmaier, Jonathan Marten, Sarah E. Harris, Ani Manichaikul, Tess D. Pottinger, Ruifang Li-Gao, Allan Lind-Thomsen, Anubha Mahajan, Lies Lahousse, Medea Imboden, Alexander Teumer, Bram Prins, Leo-Pekka Lyytikäinen, Gudny Eiriksdottir, Nora Franceschini, Colleen M. Sitlani, Jennifer A. Brody, Yohan Bossé, Wim Timens, Aldi Kraja, Anu Loukola, Wenbo Tang, Yongmei Liu, Jette Bork-Jensen, Johanne M. Justesen, Allan Linneberg, Leslie A. Lange, Rajesh Rawal, Stefan Karrasch, Jennifer E. Huffman, Blair H. Smith, Gail Davies, Kristin M. Burkart, Josyf C. Mychaleckyj, Tobias N. Bonten, Stefan Enroth, Lars Lind, Guy G. Brusselle, Ashish Kumar, Beate Stubbe, Understanding Society Scientific Group, Mika Kähönen, Annah B. Wyss, Bruce M. Psaty, Susan R. Heckbert, Ke Hao, Taina Rantanen, Stephen B. Kritchevsky, Kurt Lohman, Tea Skaaby, Charlotta Pisinger, Torben Hansen, Holger Schulz, Ozren Polasek, Archie Campbell, John M. Starr, Stephen S. Rich, Dennis O. Mook-Kanamori, Åsa Johansson, Erik Ingelsson, André G. Uitterlinden, Stefan Weiss, Olli T. Raitakari, Vilmundur Gudnason, Kari E. North, Sina A. Gharib, Don D. Sin, Kent D. Taylor, George T. O'Connor, Jaakko Kaprio, Tamara B. Harris, Oluf Pederson, Henrik Vestergaard, James G. Wilson, Konstantin Strauch, Caroline Hayward, Shona Kerr, Ian J. Deary, R. Graham Barr, Renée de Mutsert, Ulf Gyllensten, Andrew P. Morris, M. Arfan Ikram, Nicole Probst-Hensch, Sven Gläser, Eleftheria Zeggini, Terho Lehtimäki, David P. Strachan, Josée Dupuis, Alanna C. Morrison, Ian P. Hall, Martin D. Tobin, Stephanie J. London, 2018, 10.12688/wellcomeopenres.12583.3
  • Meta-analysis of exome array data identifies six novel genetic loci for lung function [version 2; referees: 2 approved], Victoria E. Jackson, Jeanne C. Latourelle, Louise V. Wain, Albert V. Smith, Megan L. Grove, Traci M. Bartz, Ma'en Obeidat, Michael A. Province, Wei Gao, Beenish Qaiser, David J. Porteous, Patricia A. Cassano, Tarunveer S. Ahluwalia, Niels Grarup, Jin Li, Elisabeth Altmaier, Jonathan Marten, Sarah E. Harris, Ani Manichaikul, Tess D. Pottinger, Ruifang Li-Gao, Allan Lind-Thomsen, Anubha Mahajan, Lies Lahousse, Medea Imboden, Alexander Teumer, Bram Prins, Leo-Pekka Lyytikäinen, Gudny Eiriksdottir, Nora Franceschini, Colleen M. Sitlani, Jennifer A. Brody, Yohan Bossé, Wim Timens, Aldi Kraja, Anu Loukola, Wenbo Tang, Yongmei Liu, Jette Bork-Jensen, Johanne M. Justesen, Allan Linneberg, Leslie A. Lange, Rajesh Rawal, Stefan Karrasch, Jennifer E. Huffman, Blair H. Smith, Gail Davies, Kristin M. Burkart, Josyf C. Mychaleckyj, Tobias N. Bonten, Stefan Enroth, Lars Lind, Guy G. Brusselle, Ashish Kumar, Beate Stubbe, Understanding Society Scientific Group, Mika Kähönen, Annah B. Wyss, Bruce M. Psaty, Susan R. Heckbert, Ke Hao, Taina Rantanen, Stephen B. Kritchevsky, Kurt Lohman, Tea Skaaby, Charlotta Pisinger, Torben Hansen, Holger Schulz, Ozren Polasek, Archie Campbell, John M. Starr, Stephen S. Rich, Dennis O. Mook-Kanamori, Åsa Johansson, Erik Ingelsson, André G. Uitterlinden, Stefan Weiss, Olli T. Raitakari, Vilmundur Gudnason, Kari E. North, Sina A. Gharib, Don D. Sin, Kent D. Taylor, George T. O'Connor, Jaakko Kaprio, Tamara B. Harris, Oluf Pederson, Henrik Vestergaard, James G. Wilson, Konstantin Strauch, Caroline Hayward, Shona Kerr, Ian J. Deary, R. Graham Barr, Renée de Mutsert, Ulf Gyllensten, Andrew P. Morris, M. Arfan Ikram, Nicole Probst-Hensch, Sven Gläser, Eleftheria Zeggini, Terho Lehtimäki, David P. Strachan, Josée Dupuis, Alanna C. Morrison, Ian P. Hall, Martin D. Tobin, Stephanie J. London, 2018, 10.12688/wellcomeopenres.12583.2
  • Identification of Drug Candidates to Suppress Cigarette Smoke–induced Inflammation via Connectivity Map Analyses, Gilles Vanderstocken, Anna Dvorkin-Gheva, Pamela Shen, Corry-Anke Brandsma, Ma’en Obeidat, Yohan Bossé, John A. Hassell, Martin R. Stampfli, American Journal of Respiratory Cell and Molecular Biology, 2018, 10.1165/rcmb.2017-0202OC
  • Clinical Experience with SERPINA1 DNA Sequencing to Detect Alpha-1 Antitrypsin Deficiency, François Maltais, Nathalie Gaudreault, Christine Racine, Sébastien Thériault, Yohan Bossé, Annals of the American Thoracic Society, 2018, 10.1513/AnnalsATS.201708-694RL
  • Meta-analysis of exome array data identifies six novel genetic loci for lung function [version 1; referees: awaiting peer review], Victoria E. Jackson, Jeanne C. Latourelle, Louise V. Wain, Albert V. Smith, Megan L. Grove, Traci M. Bartz, Ma'en Obeidat, Michael A. Province, Wei Gao, Beenish Qaiser, David J. Porteous, Patricia A. Cassano, Tarunveer S. Ahluwalia, Niels Grarup, Jin Li, Elisabeth Altmaier, Jonathan Marten, Sarah E. Harris, Ani Manichaikul, Tess D. Pottinger, Ruifang Li-Gao, Allan Lind-Thomsen, Anubha Mahajan, Lies Lahousse, Medea Imboden, Alexander Teumer, Bram Prins, Leo-Pekka Lyytikäinen, Gudny Eiriksdottir, Nora Franceschini, Colleen M. Sitlani, Jennifer A. Brody, Yohan Bossé, Wim Timens, Aldi Kraja, Anu Loukola, Wenbo Tang, Yongmei Liu, Jette Bork-Jensen, Johanne M. Justesen, Allan Linneberg, Leslie A. Lange, Rajesh Rawal, Stefan Karrasch, Jennifer E. Huffman, Blair H. Smith, Gail Davies, Kristin M. Burkart, Josyf C. Mychaleckyj, Tobias N. Bonten, Stefan Enroth, Lars Lind, Guy G. Brusselle, Ashish Kumar, Beate Stubbe, Understanding Society Scientific Group, Mika Kähönen, Annah B. Wyss, Bruce M. Psaty, Susan R. Heckbert, Ke Hao, Taina Rantanen, Stephen B. Kritchevsky, Kurt Lohman, Tea Skaaby, Charlotta Pisinger, Torben Hansen, Holger Schulz, Ozren Polasek, Archie Campbell, John M. Starr, Stephen Rich, Dennis O. Mook-Kanamori, Åsa Johansson, Erik Ingelsson, André G. Uitterlinden, Stefan Weiss, Olli T. Raitakari, Vilmundur Gudnason, Kari E. North, Sina A. Gharib, Don D. Sin, Kent D. Taylor, George T. O'Connor, Jaakko Kaprio, Tamara B. Harris, Oluf Pederson, Henrik Vestergaard, James G. Wilson, Konstantin Strauch, Caroline Hayward, Shona Kerr, Ian Deary, R. Graham Barr, Renée de Mutsert, Ulf Gyllensten, Andrew P. Morris, M. Arfan Ikram, Nicole Probst-Hensch, Sven Gläser, Eleftheria Zeggini, Terho Lehtimäki, David P. Strachan, Josee Dupuis, Alanna C. Morrison, Ian P. Hall, Martin D. Tobin, Stephanie J. London, 2018, 10.12688/wellcomeopenres.12583.1
  • Surfactant protein D is a causal risk factor for COPD: results of Mendelian randomisation, Ma'en Obeidat, Xuan Li, Stephen Burgess, Guohai Zhou, Nick Fishbane, Nadia N. Hansel, Yohan Bossé, Philippe Joubert, Ke Hao, David C. Nickle, Maarten van den Berge, Wim Timens, Michael H. Cho, Brian D. Hobbs, Kim de Jong, Marike Boezen, Rayjean J. Hung, Nicholas Rafaels, Rasika Mathias, Ingo Ruczinski, Terri H. Beaty, Kathleen C. Barnes, Peter D. Paré, Don D. Sin, European Respiratory Journal, 2017, 10.1183/13993003.00657-2017
  • A Potent Tartrate Resistant Acid Phosphatase Inhibitor to Study the Function of TRAP in Alveolar Macrophages, Carian E. Boorsma, T. Anienke van der Veen, Kurnia S. S. Putri, Andreia de Almeida, Christina Draijer, Thais Mauad, Gyorgy Fejer, Corry-Anke Brandsma, Maarten van den Berge, Yohan Bossé, Don Sin, Ke Hao, Anja Reithmeier, Göran Andersson, Peter Olinga, Wim Timens, Angela Casini, Barbro N. Melgert, Scientific Reports, 2017, 10.1038/s41598-017-12623-w
  • Integrative Genomics of Emphysema-Associated Genes Reveals Potential Disease Biomarkers, Ma’en Obeidat, Yunlong Nie, Nick Fishbane, Xuan Li, Yohan Bossé, Philippe Joubert, David C. Nickle, Ke Hao, Dirkje S. Postma, Wim Timens, Marc A. Sze, Casey P. Shannon, Zsuzsanna Hollander, Raymond T. Ng, Bruce McManus, Bruce E. Miller, Stephen Rennard, Avrum Spira, Tillie-Louise Hackett, Wan Lam, Stephen Lam, Rosa Faner, Alvar Agusti, James C. Hogg, Don D. Sin, Peter D. Paré, American Journal of Respiratory Cell and Molecular Biology, 2017, 10.1165/rcmb.2016-0284OC
  • A transcriptome-wide association study identifies PALMD as a susceptibility gene for calcific aortic valve stenosis, Sébastien Thériault, Nathalie Gaudreault, Maxime Lamontagne, David Messika-Zeitoun, Marie-Annick Clavel, Romain Capoulade, François Dagenais, Philippe Pibarot, Patrick Mathieu, Yohan Bossé, 2017, 10.1101/184945
  • Genome-Wide Interaction Analysis of Air Pollution Exposure and Childhood Asthma with Functional Follow-up, Anna Gref, Simon K. Merid, Olena Gruzieva, Stéphane Ballereau, Allan Becker, Tom Bellander, Anna Bergström, Yohan Bossé, Matteo Bottai, Moira Chan-Yeung, Elaine Fuertes, Despo Ierodiakonou, Ruiwei Jiang, Stéphane Joly, Meaghan Jones, Michael S. Kobor, Michal Korek, Anita L. Kozyrskyj, Ashish Kumar, Nathanaël Lemonnier, Elaina MacIntyre, Camille Ménard, David Nickle, Ma'en Obeidat, Johann Pellet, Marie Standl, Annika Sääf, Cilla Söderhäll, Carla M. T. Tiesler, Maarten van den Berge, Judith M. Vonk, Hita Vora, Cheng-Jian Xu, Josep M. Antó, Charles Auffray, Michael Brauer, Jean Bousquet, Bert Brunekreef, W. James Gauderman, Joachim Heinrich, Juha Kere, Gerard H. Koppelman, Dirkje Postma, Christopher Carlsten, Göran Pershagen, Erik Melén, American Journal of Respiratory and Critical Care Medicine, 2017, 10.1164/rccm.201605-1026OC
  • Autoantibodies and immune complexes to oxidation-specific epitopes and progression of aortic stenosis: Results from the ASTRONOMER trial, Romain Capoulade, Kwan L. Chan, Patrick Mathieu, Yohan Bossé, Jean G. Dumesnil, James W. Tam, Koon K. Teo, Xiaohong Yang, Joseph L. Witztum, Benoit J. Arsenault, Jean-Pierre Després, Philippe Pibarot, Sotirios Tsimikas, Atherosclerosis, 2017, 10.1016/j.atherosclerosis.2017.03.013
  • Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis, Brian D Hobbs, Kim de Jong, Maxime Lamontagne, Yohan Bossé, Nick Shrine, María Soler Artigas, Louise V Wain, Ian P Hall, Victoria E Jackson, Annah B Wyss, Stephanie J London, Kari E North, Nora Franceschini, David P Strachan, Terri H Beaty, John E Hokanson, James D Crapo, Peter J Castaldi, Robert P Chase, Traci M Bartz, Susan R Heckbert, Bruce M Psaty, Sina A Gharib, Pieter Zanen, Jan W Lammers, Matthijs Oudkerk, H J Groen, Nicholas Locantore, Ruth Tal-Singer, Stephen I Rennard, Jørgen Vestbo, Wim Timens, Peter D Paré, Jeanne C Latourelle, Josée Dupuis, George T O'Connor, Jemma B Wilk, Woo Jin Kim, Mi Kyeong Lee, Yeon-Mok Oh, Judith M Vonk, Harry J de Koning, Shuguang Leng, Steven A Belinsky, Yohannes Tesfaigzi, Ani Manichaikul, Xin-Qun Wang, Stephen S Rich, R Graham Barr, David Sparrow, Augusto A Litonjua, Per Bakke, Amund Gulsvik, Lies Lahousse, Guy G Brusselle, Bruno H Stricker, André G Uitterlinden, Elizabeth J Ampleford, Eugene R Bleecker, Prescott G Woodruff, Deborah A Meyers, Dandi Qiao, David A Lomas, Jae-Joon Yim, Deog Kyeom Kim, Iwona Hawrylkiewicz, Pawel Sliwinski, Megan Hardin, Tasha E Fingerlin, David A Schwartz, Dirkje S Postma, William MacNee, Martin D Tobin, Edwin K Silverman, H Marike Boezen, Michael H Cho, Nature Genetics, 2017, 10.1038/ng.3752
  • Novel Genetic Susceptibility Loci for FEV1 in the Context of Occupational Exposure in Never-Smokers, Kim de Jong, Judith M. Vonk, Alen Faiz, Diana A. van der Plaat, Wim Timens, Yohan Bossé, Hans Kromhout, Ivana Nedeljkovic, Dirkje S. Postma, H. Marike Boezen, American Journal of Respiratory and Critical Care Medicine, 2016, 10.1164/rccm.201603-0646LE
  • Identification of Gender-Specific Genetic Variants in Patients With Bicuspid Aortic Valve, Natasha Dargis, Maxime Lamontagne, Nathalie Gaudreault, Laura Sbarra, Cyndi Henry, Philippe Pibarot, Patrick Mathieu, Yohan Bossé, The American Journal of Cardiology, 2016, 10.1016/j.amjcard.2015.10.058

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Veronique Boumtje - Doctorat - En cours
  • Ran Xu - Doctorat - En cours
  • Louis-Jacques Ruel - Maîtrise avec mémoire - En cours
  • Macarena Yamila López González - Doctorat - En cours
  • Ahmed Fayez Hadji - Doctorat - En cours
  • Maxime Lamontagne - Maîtrise avec mémoire - En cours
  • Babatounde elias Aila - Maîtrise avec mémoire - En cours
  • Mona Patoughi - Doctorat - En cours
  • Soumiya Amellah - Doctorat - En cours
  • Martine Voisine - Maîtrise avec mémoire - En cours
  • Olga Sazonova - Doctorat - En cours
  • Sandra Milena Guauque - Doctorat - 2015/09
  • Alisson Clemenceau - Maîtrise avec mémoire - 2017/09
  • Nicolas Perrot - Doctorat - 2020/05

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