Vincenzo Di Marzo

Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474, Mario van der Stelt, Steven A. Kushner, Benjamin F. Cravatt, Mauro Maccarrone, Vincenzo Di Marzo, Chris I. De Zeeuw, Thomas Hankemeier, Herman S. Overkleeft, Luciano De Petrocellis, Giel Hendriks, Bogdan I. Florea, Ilse L. Baak, Hans den Dulk, Elliot D. Mock, Marjolein Soethoudt, Tom van der Wel, Zhanmin Lin, Filomena Fezza, Marco Allarà, Hui Deng, Femke M. S. de Vrij, Marc P. Baggelaar, Vasudev Kantae, Mark van der Kroeg, Guy Shpak, Daisuke Ogasawara, Armand B. Cognetta, Antonius P. A. Janssen, Annelot C. M. van Esbroeck, Science, 2017, 10.1126/science.aaf7497

Rimonabant precipitates anxiety in rats withdrawn from palatable food: Role of the central Amygdala, Cottone, P., Zorrilla, E.P., Di Marzo, V., Iannotti, F.A., Orlando, P., Rice, K.C., Steardo, L., Petrosino, S., Sabino, V., Iemolo, A., Blasio, A., 2013, 10.1038/npp.2013.153

Pharmacological modulation of the endocannabinoid system in a viral model of multiple sclerosis, Guaza, C., Di Marzo, V., Ortar, G., Valenti, M., Molina-Holgado, E., Arévalo-Martín, A., Correa, F., Mestre, L., 2005, 10.1111/j.1471-4159.2004.02979.x

MicroRNA-mediated repression of endocannabinoid CB1 receptor expression contributes to simvastatin-induced skeletal muscle toxicity, Fabio Iannotti, Vincenzo Di Marzo, Raffaele Capasso, Fabiana Piscitelli, Claudia Moriello, Giuseppe Ercolano, Ester Pagano, Elisabetta Panza, Hilal Kalkan, 2022, 10.21203/rs.3.rs-2328769/v1

Endocannabinoid system and mood disorders: Priming a target for new therapies, Drago, F., Wotjak, C.T., Sulcova, A., Di Marzo, V., Micale, V., 2013, 10.1016/j.pharmthera.2012.12.002

Synthesis, binding assays, cytotoxic activity and docking studies of benzimidazole and benzothiophene derivatives with selective affinity for the CB2 cannabinoid receptor, Pessoa-Mahana, C.D., Di Marzo, V., Faúndez, M., Escobar, R., Iturriaga-Vásquez, P., Pessoa-Mahana, H., Torres, M.J., Allarà, M., Palmieri, V., Mella-Raipán, J., Romero-Parra, J., European Journal of Medicinal Chemistry, 2016, 10.1016/j.ejmech.2016.08.005

A structure/activity relationship study on arvanil, an endocannabinoid and vanilloid hybrid, Martin, B.R., Razdan, R.K., Mahadevan, A.N.U., Kulasegram, S., Grier, M.C., Williams, W., Bisogno, T., Brandi, I., De Petrocellis, L., Griffin, G., Di Marzo, V., 2002, 10.1124/jpet.300.3.984

Genetic Manipulation of sn-1-Diacylglycerol Lipase and CB₁Cannabinoid Receptor Gain-of-Function Uncover Neuronal 2-Linoleoyl Glycerol Signaling in Drosophila melanogaster, Harkany, T., Doherty, P., Keimpema, E., Di Marzo, V., Williams, M.J., Mackie, K., Cameron, G.A., Williams, G., Romani, S., Beiersdorf, J., Tortoriello, G., Cannabis and Cannabinoid Research, 2021, 10.1089/can.2020.0010

Synthesis and biological evaluation of new N-alkyl 1-aryl-5-(1H-pyrrol-1- yl)-1H-pyrazole-3-carboxamides as cannabinoid receptor ligands, Corelli, F., Dondio, G., Di Marzo, V., Colombo, G., Novellino, E., Sinisi, R., Rozio, M.G., Bigogno, C., Carai, M.A.M., Fantini, N., Allar, M., Pasquini, S., Brizzi, A., Lavecchia, A., Gatti, V., Piscitelli, F., La Regina, G., Ligresti, A., Silvestri, R., 2010, 10.1016/j.ejmech.2010.09.053

Endocannabinoids: A unique opportunity to develop multitarget analgesics, Di Marzo, V., Costa, B., Maione, S., 2013, 10.1016/j.pain.2013.03.023

Anandamide interferes with human endometrial stromal-derived cell differentiation: An effect dependent on inhibition of cyclooxygenase-2 expression and prostaglandin E2 release, Teixeira, N., Correia-da-Silva, G., Di Marzo, V., Piscitelli, F., Amaral, C., Fonseca, B.M., Cunha, S., Almada, M., BioFactors, 2016, 10.1002/biof.1270

Structure-activity relationship for the endogenous cannabinoid, anandamide, and certain of its analogues at vanilloid receptors in transfected cells and vas deferens, Pertwee, R.G., Di Marzo, V., Craib, S.J., Pashmi, G., Leslie, M., Brockie, H.C., Gibson, T.M., Ross, R.A., 2001

Intuitive eating is associated with elevated levels of circulating omega-3-polyunsaturated fatty acid-derived endocannabinoidome mediators, Veilleux, A., Di Marzo, V., Flamand, N., Martin, C., Lacroix, S., Perron, J., Castonguay-Paradis, S., Provencher, V., Rochefort, G., Appetite, 2021, 10.1016/j.appet.2020.104973

Endocannabinoid regulation in white and brown adipose tissue following thermogenic activation, Di Marzo, V., Heeren, J., Silvestri, C., Scheja, L., Borrino, S., Heine, M., Piscitelli, F., Krott, L.M., Journal of Lipid Research, 2016, 10.1194/jlr.M065227

Palmitoylethanolamide Supplementation during Sensitization Prevents Airway Allergic Symptoms in the Mouse, Angelo A. Izzo, Vincenzo Di Marzo, Raffaele Capasso, Alessio Peritore, Carla Cicala, Andrea Guarino, Armando Ialenti, Valentina M. Iacono, Maria A. Riemma, Pierangelo Orlando, Elisabetta Caiazzo, Antonietta Rossi, Fiorentina Roviezzo, Frontiers in Pharmacology, 2017, 10.3389/fphar.2017.00857

Conformationally constrained fatty acid ethanolamides as cannabinoid and vanilloid receptor probes, Di Marzo, V., De Petrocellis, L., Pertwee, R.G., Taglialatela-Scafati, O., Allarà, M., Cascio, M.G., Minassi, A., Ligresti, A., Appendino, G., 2009, 10.1021/jm900130m

N-palmitoyl-ethanolamine: Biochemistry and new therapeutic opportunities, Di Marzo, V., Iuvone, T., Petrosino, S., 2010, 10.1016/j.biochi.2010.01.006

Synthetic bioactive olivetol-related amides: The influence of the phenolic group in cannabinoid receptor activity, Di Marzo, V., Pertwee, R.G., Manera, C., Maione, S., Corelli, F., Pessina, F., Mugnaini, C., Marini, P., Luongo, L., Ligresti, A., Gado, F., Frosini, M., De Petrocellis, L., Cascio, M.G., Boccella, S., Aiello, F., Brizzi, A., Bioorganic and Medicinal Chemistry, 2020, 10.1016/j.bmc.2020.115513

FAAH Pro129Thr Variant Is Associated with Increased Cholesterol Levels in Normal-Weight Metabolically Unhealthy Subjects, Martínez-López, E., Di Marzo, V., Lopez-Cortes, O.D., Campos-Pérez, W., Vizmanos, B., Torres-Castillo, N., Sierra-Ruelas, E., Metabolic Syndrome and Related Disorders, 2023, 10.1089/met.2023.0014

Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb, Mechoulam, R., Di Marzo, V., Capasso, R., Borrelli, F., Izzo, A.A., 2009, 10.1016/j.tips.2009.07.006

Mechanisms of the anti-obesity effects of oxytocin in diet-induced obese rats, Rohner-Jeanrenaud, F., Di Marzo, V., Wahli, W., Foti, M., Geenen, V., Legros, J.-J., Piscitelli, F., Petrosino, S., Bussier, A.-L., Caillon, A., Bourgoin, L., Veyrat-Durebex, C., Deblon, N., 2011, 10.1371/journal.pone.0025565

Arachidonic acid, protein kinase C activators and bud formation in Hydra vulgaris, Minei, R., Gianfrani, C., Di Marzo, V., De Petrocellis, L., 1993, 10.1016/0742-8413(93)90198-T

Endocannabinoid synthesis and degradation, and their regulation in the framework of energy balance., Di Marzo, V., Matias, I., 2006

Novel diterpenoid diacylglycerols from marine molluscs: Potent morphogens and protein kinase C activators, Di Marzo, V., Cimino, G., Ventriglia, M., Gavagnin, M., Orlando, P., De Petrocellis, L., 1996

Erratum to: Responses of peripheral endocannabinoids and endocannabinoid‑related compounds to hedonic eating in obesity (Eur J Nutr, 2016, DOI 10.1007/s00394-016-1153-9), Maj, M., Calugi, S., Volpe, U., Piscitelli, F., El Ghoch, M., Aveta, T., Dalle Grave, R., Monteleone, P., Di Marzo, V., Monteleone, A.M., European Journal of Nutrition, 2016, 10.1007/s00394-016-1204-2

Periaqueductal gray metabotropic glutamate receptor subtype 7 and 8 mediate opposite effects on amino acid release, rostral ventromedial medulla cell activities, and thermal nociception, Maione, S., Rossi, F., Di Marzo, V., Guida, F., Gatta, L., Vita, D., Cristino, L., Starowicz, K., De Novellis, V., Palazzo, E., Rossi, F., Marabese, I., 2007, 10.1152/jn.00356.2007

Role of Endocannabinoids and Cannabinoid-1 Receptors in Cerebrocortical Blood Flow Regulation, Benyó, Z., Pacher, P., Di Marzo, V., Sándor, P., Járai, Z., Lacza, Z., Benko, R., Horváth, B., Leszl-Ishiguro, M., Ruisanchez, É., Iring, A., 2013, 10.1371/journal.pone.0053390

Protective role of palmitoylethanolamide in contact allergic dermatitis, Di Marzo, V., Iuvone, T., Zimmer, A., Orlando, P., Saturnino, C., D'Amico, A., De Filippis, D., Bisogno, T., Tüting, T., Ueda, N., Gaffal, E., Karsak, M., Cristino, L., Petrosino, S., 2010, 10.1111/j.1398-9995.2009.02254.x

Diacylglycerol lipase is not involved in depolarization-induced suppression of inhibition at unitary inhibitory connections in mouse hippocampus, Mansvelder, H.D., Burnashev, N., Brussaard, A.B., Di Marzo, V., Bisogno, T., Lodder, J.C., Canto, C.B., Heistek, T.S., Testa-Silva, G., Min, R., 2010, 10.1523/JNEUROSCI.BC-3622-09.2010

Neuroscience: Identification and functional characterization of brainstem cannabinoid CB₂ receptors, Sharkey, K.A., Patel, K.D., Pittman, Q.J., Di Marzo, V., Marnett, L.J., Davison, J.S., Piomelli, D., Makriyannis, A., Stella, N., Mackie, K., Urbani, P., Mouihate, A., Kingsley, P.J., Duncan, M., Van Sickle, M.D., Science, 2005, 10.1126/science.1115740

Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders, Friedman, D., Whalley, B., Thiele, E., Rohrback, B.G., Robson, P.J., Martinez-Orgado, J., Notcutt, W.G., Jutras-Aswad, D., Di Marzo, V., Katz, R., Hill, C., French, J., Fernandez-Ruiz, J., Cross, H., Cilio, M.R., Devinsky, O., 2014, 10.1111/epi.12631

Preparation and characterization of Δ⁹- tetrahydrocannabinol-loaded biodegradable polymeric microparticles and their antitumoral efficacy on cancer cell lines, Di Marzo, V., Torres, A.I., Molpeceres, J., Aberturas, M.D.R., Ligresti, A., Gil-Alegre, M.E., De La Ossa, D.H.P., Journal of Drug Targeting, 2013, 10.3109/1061186X.2013.809089

A new strategy to block tumor growth by inhibiting endocannabinoid inactivation, Di Marzo, V., Portella, G., Ligresti, A., Valenti, M., Laezza, C., Bifulco, M., 2004, 10.1096/fj.04-1754fje

Enantiospecific synthesis of bioactive hydroxyeicosatetraenoic acids (HETEs) in Hydra magnipapillata, Di Marzo, V., De Petrocellis, L., Muller, W., Leitz, T., 1994, 10.1016/0005-2760(94)90029-9

Deranged endocannabinoid responses to hedonic eating in underweight and recently weight-restored patients with anorexia nervosa, Maj, M., Monteleone, P., Calugi, S., El Ghoch, M., Scognamiglio, P., Dalle Grave, R., Piscitelli, F., Aveta, T., Di Marzo, V., Monteleone, A.M., American Journal of Clinical Nutrition, 2015, 10.3945/ajcn.114.096164

Analysis of anandamide, an endogenous cannabinoid substance, and of other natural N-acylethanolamines, Piomelli, D., Cadas, H., Di Marzo, V., Fontana, A., 1995, 10.1016/0952-3278(95)90130-2

N-Acylethanolamine acid amidase (NAAA) is dysregulated in colorectal cancer patients and its inhibition reduces experimental cancer growth, Izzo, A.A., Borrelli, F., Di Marzo, V., Venneri, T., Sbarro, B., Capasso, R., D'Armiento, M., Aprea, G., De Luca, M., Malamas, M., Makriyannis, A., Lionetti, R., Cicia, D., Di Tella, F., Vanacore, G., Sparaco, R., Fiorino, F., Nanì, M.F., Lucariello, G., Brancaleone, V., Piscitelli, F., Iannotti, F.A., Pagano, E., Romano, B., British Journal of Pharmacology, 2022, 10.1111/bph.15737

Obesity-driven synaptic remodeling affects endocannabinoid control of orexinergic neurons, Marzo, V.D., Mackie, K., Bentivoglio, M., Orlando, P., Petrosino, S., Silvestri, C., Palomba, L., Ferrandino, I., Imperatore, R., Busetto, G., Cristino, L., Proceedings of the National Academy of Sciences of the United States of America, 2013, 10.1073/pnas.1219485110

Structure-based virtual screening: Identification of novel CB2 receptor ligands, Martinelli, A., Saccomanni, G., Ortore, G., Manera, C., Di Marzo, V., Cascio, M.G., Tuccinardi, T., 2007, 10.2174/157018007778992829

The endocannabinoid system in the basal ganglia and in the mesolimbic reward system: Implications for neurological and psychiatric disorders, Di Marzo, V., Van Der Stelt, M., 2003, 10.1016/j.ejphar.2003.08.101

Synthesis, biological activity and molecular modeling of new biphenylic carboxamides as potent and selective CB2 receptor ligands, Macchia, M., Manera, C., Novellino, E., Di Marzo, V., Marinelli, L., Bruno, A., Allarà, M., Ligresti, A., Saguto, S., Saccomanni, G., Arena, C., Savinainen, J.R., Parkkari, T., Bertini, S., 2015, 10.1016/j.ejmech.2014.11.066

Endocannabinoids and Related Compounds: Walking Back and Forth between Plant Natural Products and Animal Physiology, De Petrocellis, L., Bisogno, T., Di Marzo, V., 2007, 10.1016/j.chembiol.2007.05.014

Cell signalling: Why fasting worms age slowly, Di Marzo, V., De Petrocellis, L., 2011, 10.1038/473161a

1-Aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide: An effective scaffold for the design of either CB ₁ or CB ₂ receptor ligands, Silvestri, R., Corelli, F., Di Marzo, V., Colombo, G., Novellino, E., Carai, M.A.M., Allar, M., Pasquini, S., Brizzi, A., Gatti, V., La Regina, G., Ligresti, A., Piscitelli, F., European Journal of Medicinal Chemistry, 2011, 10.1016/j.ejmech.2011.09.037

Novel inhibitors of brain, neuronal, and basophilic anandamide amidohydrolase, Di Marzo, V., Marino, G., Yamamoto, S., Kurahashi, Y., Maurelli, S., Ueda, N., Melck, D., De Petrocellis, L., 1997, 10.1006/bbrc.1997.6000

Investigations on the 4-quinolone-3-carboxylic acid motif. 6. Synthesis and pharmacological evaluation of 7-substituted quinolone-3-carboxamide derivatives as high affinity ligands for cannabinoid receptors, Corelli, F., Di Marzo, V., Pertwee, R.G., Bolognini, D., Cascio, M.G., Caradonna, N.P., Brizzi, A., Mugnaini, C., Ligresti, A., De Rosa, M., Pasquini, S., 2012, 10.1016/j.ejmech.2012.09.035

Cannabinoid CB1 receptor elevation of intracellular calcium in neuroblastoma SH-SY5Y cells: Interactions with muscarinic and δ-opioid receptors, Di Marzo, V., De Petrocellis, L., Palmery, M., Cristino, L., Moriello, A.S., Marini, P., 2009, 10.1016/j.bbamcr.2009.05.002

Trick or treat from food endocannabinoids? [4] (multiple letters), Piomelli, D., Beltramo, M., Mechoulam, R., Fride, E., Crozier, G., Berger, A., De Petrocellis, L., Sepe, N., Di Marzo, V., 1998

Endocannabinoid Tone Regulates Human Sebocyte Biology, Tamás Szabó, Tamás Bíró, Vincenzo Di Marzo, Jürg Gertsch, Christos C. Zouboulis, Ilona Kovács, Ágnes Pór, Marco Allarà, Fabiana Piscitelli, Simon Nicolussi, Andrea Aranyász, Erika Takács, Arnold Markovics, Attila Oláh, Nóra Zákány, Journal of Investigative Dermatology, 2018, 10.1016/j.jid.2018.02.022

Modulation of thermo-transient receptor potential (thermo-TRP) channels by thymol-based compounds, De Petrocellis, L., Di Marzo, V., Nalli, M., Morera, E., Schiano Moriello, A., Morera, L., Ortar, G., 2012, 10.1016/j.bmcl.2012.03.055

Analysis of cannabinoid receptor binding and mRNA expression and endogenous cannabinoid contents in the developing rat brain during late gestation and early postnatal period, Fernández-Ruiz, J.J., Di Marzo, V., Ramos, J.A., Sepe, N., Berrendero, F., 1999, 10.1002/(SICI)1098-2396(19990901)33:3<181::AID-SYN3>3.0.CO;2-R

Differential diurnal variations of anandamide and 2-arachidonoyl-glycerol levels in rat brain, Di Marzo, V., Parolaro, D., Steardo, L., Cascio, M.G., Rubino, T., Viganò, D., Valenti, M., 2004, 10.1007/s00018-003-3453-5

Iodinated N-acylvanillamines: Potential "multiple-target" anti-inflammatory agents acting via the inhibition of T-cell activation and antagonism at vanilloid TRPV1 channels, Di Marzo, V., Mũnoz, E., Appendino, G., Minassi, A., Schiano-Moriello, A., Macho, A., Caballero, F.J., De Petrocellis, L., Ḿarquez, N., 2006, 10.1124/mol.105.019786

Anti-inflammatory Properties of Cannabidiol, a Nonpsychotropic Cannabinoid, in Experimental Allergic Contact Dermatitis, Vincenzo Di Marzo, Teresa Iuvone, Marco Allarà, Massimo Vaia, Roberta Verde, Stefania Petrosino, Journal of Pharmacology and Experimental Therapeutics, 2018, 10.1124/jpet.117.244368

The hypothalamic levels of the endocannabinoid, anandamide, peak immediately before the onset of puberty in female rats, Di Marzo, V., Fernandez-Ruiz, J., Bisogno, T., González, S., Fezza, F., Gerendai, I., Wenger, T., 2002, 10.1016/S0024-3205(01)01516-8

Design, synthesis, binding, and molecular modeling studies of new potent ligands of cannabinoid receptors, Di Marzo, V., Tuccinardi, T., Martinelli, A., Dinatolo, M.T., Bisogno, T., Brizzi, V., Cascio, M.G., Brizzi, A., 2007, 10.1016/j.bmc.2007.05.060

Biaryl tetrazolyl ureas as inhibitors of endocannabinoid metabolism: Modulation at the N-portion and distal phenyl ring, Di Marzo, V., Pirolli, A., Ragno, R., Nalli, M., Morera, L., Schiano Moriello, A., Ligresti, A., De Petrocellis, L., Morera, E., Ortar, G., 2013, 10.1016/j.ejmech.2013.02.005

Effect of polyunsaturated fatty acids on endocannabinoid and N-acyl-ethanolamine levels in mouse adipocytes, Di Marzo, V., Banni, S., Petrosino, S., Murru, E., Carta, G., Matias, I., 2008, 10.1016/j.bbalip.2007.11.001

Second generation CB1 receptor blockers and other inhibitors of peripheral endocannabinoid overactivity and the rationale of their use against metabolic disorders, Di Marzo, V., Silvestri, C., 2012, 10.1517/13543784.2012.704019

Interactions between synthetic vanilloids and the endogenous cannabinoid system, De Petrocellis, L., Pertwee, R., Stevenson, L., Brockie, H., Ross, R., Melck, D., Bisogno, T., Di Marzo, V., 1998, 10.1016/S0014-5793(98)01175-2

Anxiolytic effects in mice of a dual blocker of fatty acid amide hydrolase and transient receptor potential vanilloid type-1 channels, Di Marzo, V., Drago, F., Leggio, G.M., Petrosino, S., Tamburella, A., Cristino, L., Micale, V., 2009, 10.1038/npp.2008.98

Cannabimimetic fatty acid derivatives: The anandamide family and other 'endocannabinoids', Martin, B.R., Melck, D., De Petrocellis, L., Bisogno, T., Di Marzo, V., 1999

Use of palmitoylethanolamide in the entrapment neuropathy of the median in the wrist, Di Marzo, V., Schievano, C., Foster, P.S., Drago, V., Conigliaro, R., 2011

Elevation of endocannabinoid levels in the ventrolateral periaqueductal grey through inhibition of fatty acid amide hydrolase affects descending nociceptive pathways via both cannabinoid receptor type 1 and transient receptor potential vanilloid type-1 receptors, Di Marzo, V., Rossi, F., Guglielmotti, V., Petrosino, S., Valenti, M., Cristino, L., Palazzo, E., De Novellis, V., Bisogno, T., Maione, S., 2006, 10.1124/jpet.105.093286

Orexin-A represses satiety-inducing POMC neurons and contributes to obesity via stimulation of endocannabinoid signaling, Cristino, L., Di Marzo, V., Orlando, P., Piscitelli, F., Buono, L., Sacchetti, L., Pasanisi, F., Labruna, G., Finelli, C., Palomba, L., Imperatore, R., Morello, G., Proceedings of the National Academy of Sciences of the United States of America, 2016, 10.1073/pnas.1521304113

Anandamide and AM251, via water, modulate food intake at central and peripheral level in fish, Carnevali, O., Di Marzo, V., Petrosino, S., Migliarini, B., Piccinetti, C.C., 2010, 10.1016/j.ygcen.2009.09.017

New metabolically stable fatty acid amide ligands of cannabinoid receptors: Synthesis and receptor affinity studies, Saturnino, C., Di Marzo, V., De Martino, G., Buonerba, M., Cascio, M.G., Cavallo, P., Urbani, P., 2006, 10.1016/j.bmcl.2005.09.023

RPeoseasrcshible anandamide and palmitoylethanolamide involvement in human stroke, Di Marzo, V., Pizzolato, G., Grandi, F.C., Ferigo, L., Simonetto, M., Petrosino, S., Pizzuti, D., Naccarato, M., Lipids in Health and Disease, 2010, 10.1186/1476-511X-9-47

Anti-inflammatory effect of palmitoylethanolamide on human adipocytes, Roche, R., Di Marzo, V., Cesari, M., D'Hellencourt, C.L., Tallet, F., Petrosino, S., Matias, I., Gonthier, M.-P., Ravanan, P., Festy, F., Buyse, M., Hoareau, L., 2009, 10.1038/oby.2008.591

Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: Inhibitors of anandamide uptake with negligible capsaicin-like activity, Di Marzo, V., Pertwee, R.G., Davis, J.B., Bisogno, T., De Petrocellis, L., 2000, 10.1016/S0014-5793(00)02082-2

Anandamide receptors, Bisogno, T., Ligresti, A., Fezza, F., De Petrocellis, L., Di Marzo, V., 2002, 10.1054/plef.2001.0349

Endocannabinoids and related fatty acid amides, and their regulation, in the salivary glands of the lone star tick, Sauer, J.R., Di Marzo, V., Tucker, J.S., Dillwith, J.W., Bisogno, T., Fezza, F., 2003, 10.1016/S1388-1981(03)00087-8

Erratum: Anandamide-loaded nanoparticles: Preparation and characterization (Journal of Microencapsulation (2011) 28:3: (200-210)), Molpeceres, J., Marzo, V.D., Torres, A.I., Petrocellis, L.D., Ligresti, L., Gil, M.E., De La Ossa, D.H.P., Aberturas, M.R., Journal of Microencapsulation, 2011, 10.3109/02652048.2011.617948

Combining Mass Spectrometric Metabolic Profiling with Genomic Analysis: A Powerful Approach for Discovering Natural Products from Cyanobacteria, Gerwick, W.H., Gerwick, L., Dorrestein, P.C., Sherman, D.H., Di Marzo, V., Duggan, B.M., Monroe, E.A., Korobeynikov, A., Kinnel, R.B., Tian, I.Y., Almaliti, J., Kleigrewe, K., Journal of Natural Products, 2015, 10.1021/acs.jnatprod.5b00301

Anandamide serves two masters in the brain, Marzo, V.D., Nature Neuroscience, 2010, 10.1038/nn1210-1446

Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma, Di Marzo, V., Bifulco, M., Laezza, C., Portella, G., De Petrocellis, L., Pisanti, S., Matias, I., Starowicz, K., Moriello, A.S., Ligresti, A., 2006, 10.1124/jpet.106.105247

Cannabinoid receptors and their role in neuroprotection, Di Marzo, V., Van Der Stelt, M., 2005

Effects of Dietary Bisphenol A on the Reproductive Function of Gilthead Sea Bream (Sparus aurata) Testes, Oliana Carnevali, Jaume Pérez-Sánchez, Josep Calduch-Giner, Francesca Maradonna, Vincenzo Di Marzo, Fabiana Piscitelli, Constantinos C Mylonas, Ioannis Fakriadis, Isabel Forner-Piquer, International Journal of Molecular Sciences, 2019, 10.3390/ijms20205003

Rapid combinatorial access to a library of 1,5-disubstituted-3-indole-N- alkylacetamides as CB2 receptor ligands, Corelli, F., Ghiron, C., Di Marzo, V., Ligresti, A., Brizzi, A., Mugnaini, C., Pasquini, S., 2009, 10.1021/cc9000955

Effects of BPA on zebrafish gonads: Focus on the endocannabinoid system, Carnevali, O., Maradonna, F., Habibi, H.R., Di Marzo, V., Santangeli, S., Piscitelli, F., Beato, S., Forner-Piquer, I., Environmental Pollution, 2020, 10.1016/j.envpol.2020.114710

Role of the endocannabinoid system in the control of mouse myometrium contractility during the menstrual cycle, Francesca Borrelli, Vincenzo Di Marzo, Angelo A. Izzo, Fabiana Piscitelli, Fabio Arturo Iannotti, Lorena Buono, Antonietta Rossi, Stefania Finizio, Pierangelo Orlando, Ester Pagano, Biochemical Pharmacology, 2017, 10.1016/j.bcp.2016.11.023

Different targets of anti-glucocorticoid treatment have been proposed, acting at supra-hypothalamic, HPA axis, glucocorticoid receptor and post-receptor levels., Di Marzo, V., 2013

The cannabinoid Δ⁹-tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in two mouse models of obesity, Cawthorne, M.A., Di Marzo, V., Duncan, M., Guy, G.W., Stott, C.G., Stocker, C.J., Hislop, D.C., Silvestri, C., Zaibi, M.S., Wargent, E.T., Nutrition and Diabetes, 2013, 10.1038/nutd.2013.9

Brain regional distribution of endocannabinoids: Implications for their biosynthesis and biological function, Di Marzo, V., Fernandez-Ruiz, J.J., Ramos, J.A., Cebeira, M., Ambrosino, G., Berrendero, F., Bisogno, T., 1999, 10.1006/bbrc.1999.0254

The diet rapidly and differentially affects the gut microbiota and host lipid mediators in a healthy population, Raymond, F., Veilleux, A., Di Marzo, V., Flamand, N., Lamarche, B., Perron, J., Rochefort, G., Castonguay-Paradis, S., Bourdeau-Julien, I., Microbiome, 2023, 10.1186/s40168-023-01469-2

The endocannabinoid system and its therapeutic exploitations,Das endocannabinoid-system und seine therapeutische nutzung, De Petrocellis, L., Bifulco, M., Di Marzo, V., Perfusion, 2005

The cannabinoid TRPA1 agonist cannabichromene inhibits nitric oxide production in macrophages and ameliorates murine colitis, Izzo, A.A., Di Marzo, V., Orlando, P., Vassallo, L., Coppola, D., Pertwee, R.G., Cascio, M.G., Piscitelli, F., Capasso, R., Fasolino, I., Borrelli, F., Romano, B., 2013, 10.1111/bph.12120

The endocannabinoid system in obesity and type 2 diabetes, Di Marzo, V., 2008, 10.1007/s00125-008-1048-2

Typhoid fever epidemic in the province of Isernia,Indagini su di una epidemia di febbre tifoide in provincia di Isernia., Zampieri, A., Galanti, M.R., Di Marzo, V., Laurelli, T., Petescia, G., Manuppella, A., Greco, D., Salmaso, S., Piergentili, P., Annali Sclavo; rivista di microbiologia e di immunologia, 1981

N-oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia, Walker, J.M., Di Marzo, V., Appendino, G., Daddario, N., Zipkin, R.E., Miller, J.D., Ewing, S.A., Bisogno, T., De Petrocellis, L., Huang, S.M., Chu, C.J., 2003, 10.1074/jbc.M211231200

Maternal omega-3 intake differentially affects the endocannabinoid system in the progeny`s neocortex and hippocampus: Impact on synaptic markers, de Melo Reis, R.A., Andrade-da-Costa, B.L.D.S., Di Marzo, V., de Mello, F.G., Ferreira, B.K., Santos, T.A., Martins, D.B.G., Verde, R., Iannotti, F.A., Campos, R.M.P., Tavares-do-Carmo, M.D.G., Fraga, K.Y.D., de Velasco, P.C., Isaac, A.R., Journal of Nutritional Biochemistry, 2021, 10.1016/j.jnutbio.2021.108782

The endocannabinoid system - Back to the scene of cardiometabolic risk factors control?, Francischetti, E.A., Di Marzo, V., Genelhu, V., Martins, C.J.M., 2014, 10.1055/s-0034-1375653

The effect of cannabichromene on adult neural stem/progenitor cells, Di Marzo, V., Shinjyo, N., 2013, 10.1016/j.neuint.2013.08.002

2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents, Rampa, A., Hrelia, P., Di Marzo, V., Andrisano, V., Monti, J.-P., Allarà, M., Ligresti, A., Belluti, F., Gobbi, S., Bisi, A., Da Costa, G., Bartolini, M., Tarozzi, A., Rizzo, S., 2012, 10.1016/j.ejmech.2012.10.045

Anticonvulsive Properties of Cannabidiol in a Model of Generalized Seizure Are Transient Receptor Potential Vanilloid 1 Dependent, Whalley, B.J., Whalley, B.J., Di Marzo, V., Di Marzo, V., Jones, N.A., Stott, C.G., Gray, R.A., Cannabis and Cannabinoid Research, 2020, 10.1089/can.2019.0028

Endocannabinoid control of food intake and energy balance, Matias, I., Di Marzo, V., 2005, 10.1038/nn1457

Identification of endocannabinoids and related compounds in human fat cells, Roche, R., Di Marzo, V., Césari, M., D'Hellencourt, C.L., Chesne, S., Robert-Da Silva, C., Rouch, C., Bès-Houtmann, S., Volenti, M., Matias, I., Festy, F., Hoareau, L., Gonthier, M.-P., 2007, 10.1038/oby.2007.581

Inhibitory effects of cannabinoid CB1 receptor stimulation on tumor growth and metastatic spreading: actions on signals involved in angiogenesis and metastasis., Bifulco, M., Di Marzo, V., De Petrocellis, L., Laccetti, P., Laezza, C., Portella, G., 2003

Endocannabinoid hydrolysis inhibition unmasks that unsaturated fatty acids induce a robust biosynthesis of 2-arachidonoyl-glycerol and its congeners in human myeloid leukocytes, Flamand, N., Di Marzo, V., Boulet, L.-P., Veilleux, A., Laviolette, M., Itoh, T., Yamamoto, K., Ohashi, N., Bissonnette, E., Blanchet, M.-R., Martin, C., Dumais, É., Archambault, A.-S., Turcotte, C., FASEB Journal, 2020, 10.1096/fj.201902916R

Hypoabsorptive surgeries cause limb-dependent changes in the gut endocannabinoidome and microbiome in association with beneficial metabolic effects, Richard, D., Di Marzo, V., Silvestri, C., Marette, A., Varin, T.V., Tchernof, A., Roy, M.-C., Plamondon, J., Lemoine, N., Lebel, S., Biertho, L., Flamand, N., St-Pierre, D.H., Mukorako, P., International Journal of Obesity, 2023, 10.1038/s41366-023-01307-3

New role for the anandamide metabolite prostaglandin F2α ethanolamide: Rolling preadipocyte proliferation, Cristoforo Silvestri, Vincenzo Di Marzo, David Marsolais, Olivier Courtemanche, Besma Boubertakh, Journal of Lipid Research, 2023, 10.1016/j.jlr.2023.100444

Foreword, Di Marzo, V., 2012, 10.2174/157488912798842250

Inhibitors of endocannabinoid breakdown for pain: Not so FA(AH)cile, after all, Di Marzo, V., 2012, 10.1016/j.pain.2012.06.016

Oral Ultramicronized Palmitoylethanolamide: Plasma and Tissue Levels and Spinal Anti-hyperalgesic Effect, Vincenzo Di Marzo, Salvatore Cuzzocrea, Emanuela Esposito, Daniela Impellizzeri, Rosalia Crupi, Alessio F. Peritore, Fabiana Piscitelli, Rosalba Siracusa, Carlo Schievano, Gabriele Marcolongo, Aniello Schiano Moriello, Roberta Verde, Marika Cordaro, Stefania Petrosino, Frontiers in Pharmacology, 2018, 10.3389/fphar.2018.00249

Anandamide drives cell cycle progression through CB1 receptors in a rat model of synchronized liver regeneration, Bifulco, M., Di Marzo, V., Gazzerro, P., Laezza, C., Vitale, M., Proto, M.C., Petrosino, S., Martini, C., Pallottini, V., Picardi, P., Pisanti, S., Journal of Cellular Physiology, 2015, 10.1002/jcp.24959

2-AG promotes the expression of conditioned fear via cannabinoid receptor type 1 on GABAergic neurons, Wotjak, C.T., Viveros, M.P., Micale, V., Di Marzo, V., Terzian, A.L.B., Llorente-Berzal, A., Psychopharmacology, 2015, 10.1007/s00213-015-3917-y

Biosynthesis, release and degradation of the novel endogenous cannabimimetic metabolite 2-arachidonoylglycerol in mouse neuroblastoma cells, Di Marzo, V., De Petrocellis, L., Maurelli, S., Melck, D., Sepe, N., Bisogno, T., 1997

The cannabinoid receptor type 2 as mediator of mesenchymal stromal cell immunosuppressive properties, Maione, S., Locatelli, F., Di Marzo, V., Nobili, B., Petrosino, S., Imperatore, R., Cristino, L., Guida, F., Manzo, I., Conforti, A., Luongo, L., Bellini, G., Bernardo, M.E., Rossi, F., 2013, 10.1371/journal.pone.0080022

The endocannabinoid system in the brain of Carassius auratus and its possible role in the control of food intake, Di Marzo, V., Delgado, M.J., Franzoni, M.F., Viveros, M.P., Rubio, M., De Pedro, N., Martinez, R., Cottone, E., Valenti, M., 2005, 10.1111/j.1471-4159.2005.03406.x

An endocannabinoid tone limits excitotoxicity in vitro and in a model of multiple sclerosis, Guaza, C., Docagne, F., Di Marzo, V., Correa, F., Spagnolo, A., Mestre, L., Hernangómez, M., Petrosino, S., Loría, F., 2010, 10.1016/j.nbd.2009.09.020

Occurrence and possible biological role of the endocannabinoid system in the sea squirt Ciona intestinalis, Di Marzo, V., McPartland, J.M., Matias, I., 2005, 10.1111/j.1471-4159.2005.03103.x

Deficiency of cannabinoid receptor of type 2 worsens renal functional and structural abnormalities in streptozotocin-induced diabetic mice, Gruden, G., Di Marzo, V., Hirsch, E., Aveta, T., Rastaldi, M.P., Bruno, G., Corbelli, A., Pinach, S., Gambino, R., Bellini, S., Franco, I., Grimaldi, S., Barutta, F., 2014, 10.1038/ki.2014.165

The endocannabinoid 2-arachidonoylglycerol is responsible for the slow self-inhibition in neocortical interneurons, Bacci, A., Huguenard, J.R., Prince, D.A., Di Marzo, V., Bisogno, T., Pacioni, S., Marinelli, S., 2008, 10.1523/JNEUROSCI.0847-08.2008

Pharmacological differentiation of bimatoprost and latanoprost induced ocular hypotension by a second generation prostamide antagonist (AGN 211336), Ortar, G., DiMarzo, V., Hopper, L.D., Pettit, N.S., Martos, L.J., Fliri, G.H., Cornell, L.C., Carling, Garst, E.M., Wheeler, A.L., Kharlamb, B.A., Guzman, M.V., Li, C., Wang, W.J., Liang, Y., Woodward, F.D., Prostaglandins: Biochemistry, Functions, Types and Roles, 2011

The endocannabinoid 2-arachidonoyl-glycerol controls odor sensitivity in larvae of Xenopus laevis, Czesnik, D., Schild, D., Di Marzo, V., Gutermann, B., Piscitelli, F., Manzini, I., Breunig, E., 2010, 10.1523/JNEUROSCI.4030-09.2010

Elevated Systemic Levels of Endocannabinoids and Related Mediators Across the Menstrual Cycle in Women with Endometriosis, Panina-Bordignon, P., Garavaglia, E., Di Marzo, V., Piscitelli, F., Verde, R., Candiani, M., Viganò, P., Cioffi, R., Sanchez, A.M., Reproductive Sciences, 2016, 10.1177/1933719116630414

Short- and long-term plasticity of the endocannabinoid system in neuropsychiatric and neurological disorders, Di Marzo, V., Bisogno, T., 2007, 10.1016/j.phrs.2007.09.002

Effect of repeated systemic administration of selective inhibitors of endocannabinoid inactivation on rat brain endocannabinoid levels, Di Marzo, V., Fernandez-Ruiz, J., Ortega-Gutierrez, S., Morera, E., Valenti, M., Petrosino, S., De Lago, E., 2005, 10.1016/j.bcp.2005.05.011

Role of N-Arachidonoyl-Serotonin (AA-5-HT) in Sleep-Wake Cycle Architecture, Sleep Homeostasis, and Neurotransmitters Regulation, Gloria Arankowsky-Sandoval, Oscar Arias-Carrión, Henning Budde, Geraldo A. M. Neto, André B. Veras, Nuno B. Rocha, Sergio Machado, Vincenzo Di Marzo, Eric Murillo-Rodríguez, Frontiers in Molecular Neuroscience, 2017, 10.3389/fnmol.2017.00152

Dopamine D₂ receptor signaling via the arachidonic acid cascade: Modulation by cAMP-dependent protein kinase A and prostaglandin E₂, Di Marzo, V., Piomelli, D., Journal of Lipid Mediators, 1992

Regulation of transient receptor potential channels of melastatin type 8 (TRPM8): Effect of cAMP, cannabinoid CB₁ receptors and endovanilloids, Di Marzo, V., Orlando, P., Vivese, M., Moriello, A.S., Starowicz, K., De Petrocellis, L., Experimental Cell Research, 2007, 10.1016/j.yexcr.2007.01.008

Enantioselective synthesis of 3(S)-hydroxy polygodial derivatives and evaluation of their vanilloid activity, Spinella, A., Di Marzo, V., De Petrocellis, L., Izzo, I., Della Monica, C., D'Acunto, M., 2010, 10.1016/j.tet.2010.11.002

Hedonic eating is associated with increased peripheral levels of ghrelin and the endocannabinoid 2-arachidonoyl-glycerol in healthy humans: A pilot study, Maj, M., Di Marzo, V., Canestrelli, B., Monteleone, A.M., Scognamiglio, P., Piscitelli, F., Monteleone, P., 2012, 10.1210/jc.2011-3018

Palmitoylethanolamide: Biochemistry, pharmacology and therapeutic use of a pleiotropic anti-inflammatory lipid mediator, Skaper, S.D., Di Marzo, V., 2013, 10.2174/1871527311312010004

Oleoyl alanine (HU595): a stable monomethylated oleoyl glycine interferes with acute naloxone precipitated morphine withdrawal in male rats, Parker, L.A., Mechoulam, R., Di Marzo, V., Leri, F., Lichtman, A.H., Iannotti, F.A., Piscitelli, F., Limebeer, C.L., Rock, E.M., Collins, S.A., Atwal, H., Farag, M., Smoum, R., Ayoub, S.M., Psychopharmacology, 2020, 10.1007/s00213-020-05570-4

Krill oil significantly decreases 2-arachidonoylglycerol plasma levels in obese subjects, Griinari, M., Di Marzo, V., Maki, K.C., Vik, H., Berge, K., Sirigu, A.R., Giordano, E., Cordeddu, L., Murru, E., Carta, G., Banni, S., 2011, 10.1186/1743-7075-8-7

Inhibitory effect of palmitoylethanolamide on gastrointestinal motility in mice, Di Marzo, V., Mascolo, N., Capasso, F., Pinto, A., Fezza, F., Izzo, A.A., Capasso, R., 2001

Expanding Research on Cannabis-Based Medicines for Liver Steatosis: A Low-Risk High-Reward Way Out of the Present Deadlock?, Carrieri, P., Burra, P., Marcellin, F., Di Marzo, V., Barré, T., Cannabis and Cannabinoid Research, 2023, 10.1089/can.2022.0014

A role for endocannabinoids in the generation of parkinsonism and levodopa-induced dyskinesia in MPTP-lesioned non-human primate models of Parkinson's disease, Brotchie, J.M., Di Marzo, V., Petrosino, S., Crossman, A.R., Hill, M., Fox, S.H., Van Der Stelt, M., 2005, 10.1096/fj.04-3010fje

A TRPV 1‐to‐secretagogin regulatory axis controls pancreatic β‐cell survival by modulating protein turnover, Tibor Harkany, Leif Groop, Ludwig Wagner, Tomas Hökfelt, Gert Lubec, Stefan Kubicek, Rickard Sandberg, Gábor Szabó, Vincenzo Di Marzo, Fabiana Piscitelli, Erzsébet Borók, Roman A Romanov, Jan Mulder, Robert Schnell, Giuseppe Tortoriello, Åsa Segerstolpe, Petter Storm, Edit Szodorai, Fatima Girach, Katarzyna Malenczyk, The EMBO Journal, 2017, 10.15252/embj.201695347

Therapy with a selective cannabinoid receptor type 2 agonist limits albuminuria and renal injury in mice with type 2 diabetic nephropathy, Benigni, A., Remuzzi, G., Abbate, M., Bénardeau, A., Ottaviani, G., Rothenhaeusler, B., Adam, J.-M., Fingerle, J., Di Marzo, V., Piscitelli, F., Verde, R., Nava, V., Rottoli, D., Villa, S., Corna, D., Locatelli, M., Zoja, C., Nephron, 2016, 10.1159/000442679

The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation, Di Marzo, V., Bifulco, M., Laezza, C., Bisogno, T., Palmisano, A., Melck, D., De Petrocellis, L., 1998, 10.1073/pnas.95.14.8375

In vivo pharmacological actions of two novel inhibitors of anandamide cellular uptake, Di Marzo, V., Fernandez-Ruiz, J., Baker, D., Bifulco, M., Pryce, G., Cabranes, A., Morera, E., Ortar, G., Ligresti, A., De Lago, E., 2004, 10.1016/j.ejphar.2003.11.027

B iological basis of cannabinoid medicines: Mechanistic insights into cannabinoid signaling could improve therapeutic applications, Harkany, T., Marzo, V.D., Keimpema, E., Science, 2021, 10.1126/science.abf6099

Genetic and pharmacological regulation of the endocannabinoid CB1 receptor in Duchenne muscular dystrophy, Vincenzo Di Marzo, Gabriella Minchiotti, Pier Lorenzo Puri, Raffaele Capasso, Diego Carrella, Giuseppe Busetto, Elisabetta Gazzerro, Fabiana Piscitelli, Silvia Consalvi, Valentina Saccone, Simone Adinolfi, Ombretta Guardiola, Ester Pagano, Fabio A. Iannotti, Nature Communications, 2018, 10.1038/s41467-018-06267-1

Palmitoylethanolamide reduces inflammation and itch in a mouse model of contact allergic dermatitis, Iuvone, T., Di Marzo, V., Carnuccio, R., Guarino, A., Negro, L., De Filippis, D., Petrosino, S., Vaia, M., European Journal of Pharmacology, 2016, 10.1016/j.ejphar.2016.10.005

N-Oleoyl-glycine reduces nicotine reward and withdrawal in mice, Raphael Mechoulam, Vincenzo Di Marzo, M. Imad Damaj, Aron H. Lichtman, Sabatino Maione, Laura Sim-Selley, Reem Smoum, Linda Parker, Gavin N. Petrie, Francesca Guida, Mohammed A. Mustafa, Bogna M. Ignatowska-Jankowska, Catia Giordano, Enrico D'Aniello, Rosa Maria Vitale, Asti Jackson, Pretal Muldoon, Fabiana Piscitelli, Giulia Donvito, Neuropharmacology, 2019, 10.1016/j.neuropharm.2018.03.020

Diacerein is a potent and selective inhibitor of palmitoylethanolamide inactivation with analgesic activity in a rat model of acute inflammatory pain, Di Marzo, V., Cuzzocrea, S., Verde, R., Allarà, M., Esposito, E., Marcolongo, G., Ahmad, A., Petrosino, S., 2015, 10.1016/j.phrs.2014.10.008

Erratum: Anandamide acts as an intracellular messenger amplifying Ca ²⁺ influx via TRPV1 channels (EMBO Journal (2005) 24 (3026-3037) DOI: 10.1038/sj.emboj.7600784, Di Marzo, V., Geppetti, P., McNaughton, P., Campi, B., Schiano Moriello, A., De Petrocellis, L., Vellani, V., Trevisani, M., Van Der Stelt, M., EMBO Journal, 2005, 10.1038/sj.emboj.7600839

Endocannabinoids in nervous system health and disease: The big picture in a nutshell, Di Marzo, V., Skaper, S.D., 2012, 10.1098/rstb.2012.0313

Mechanisms for the coupling of cannabinoid receptors to intracellular calcium mobilization in rat insulinoma β-cells, Di Marzo, V., Cristino, L., Nigam, S., Starowicz, K., Moriello, A.S., Matias, I., Marini, P., De Petrocellis, L., 2007, 10.1016/j.yexcr.2007.05.012

Synthesis, binding studies and molecular modeling of novel cannabinoid receptor ligands, Abadi, A.H., Abouzid, K.A., Marzo, V.D., Niess, R., Allar, M., Mahmoud, A.H., Osman, N.A., Bioorganic and Medicinal Chemistry, 2010, 10.1016/j.bmc.2010.10.050

Anandamide - The other side of the coin, Högestätt, E.D., Di Marzo, V., Julius, D., Zygmunt, P.M., 2000, 10.1016/S0165-6147(99)01430-3

An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors, Di Marzo, V., Walker, J.M., Geppetti, P., Davies, S.N., Miller, J.D., Chu, C.J., Krey, J.F., Petros, T.J., Tognetto, M., Fezza, F., De Petrocellis, L., Al-Hayani, A., Trevisani, M., Bisogno, T., Huang, S.M., 2002, 10.1073/pnas.122196999

Formation and inactivation of endogenous cannabinoid anandamide in central neurons, Piomelli, D., Schwartz, J.-C., Cimino, G., Schinelli, S., Cadas, H., Fontana, A., Di Marzo, V., Nature, 1994, 10.1038/372686a0

Protective role of cannabinoid receptor type 2 in a mouse model of diabetic nephropathy, Gruden, G., Perin, P.C., Di Marzo, V., Salvidio, G., Rastaldi, M.P., Gambino, R., Bruno, G., Pinach, S., Piscitelli, F., Barutta, F., 2011, 10.2337/db10-1809

Naphthalene and 2,3-dihydrobenzo[b][1,4]dioxine derivatives with extended side chains as new scaffolds of CB₂-selective ligands, Abadi, A.H., Abouzid, K.M., Di Marzo, V., Allarà, M., Klein, C.D., Mahmoud, A.H., Osman, N.A., MedChemComm, 2014, 10.1039/c4md00232f

Effect of maternal under-nutrition on pup body weight and hypothalamic endocannabinoid levels, Di Marzo, V., Vieau, D., Dupouy, J.-P., De Petrocellis, L., Lesage, J., Léonhardt, M., Matias, I., 2003, 10.1007/s000180300031

Non-psychotropic analgesic drugs from the endocannabinoid system: "Magic bullet" or "multiple-target" strategies?, Di Marzo, V., Starowicz, K., 2013, 10.1016/j.ejphar.2013.01.075

Palmitoylethanolamide normalizes intestinal motility in a model of post-inflammatory accelerated transit: Involvement of CB₁ receptors and TRPV1 channels, Izzo, A.A., Di Marzo, V., Borrelli, F., Buono, L., Aveta, T., Pagano, E., Orlando, P., Capasso, R., British Journal of Pharmacology, 2014, 10.1111/bph.12759

Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain, Butini, S., Di Marzo, V., Piomelli, D., Pittaluga, A., Ghelardini, C., Maione, S., Campiani, G., Dehouck, M.-P., Bertucci, C., Piscitelli, F., Ligresti, A., Luongo, L., Armirotti, A., Jung, K.-M., Landry, C., Bonfiglio, T., Tedesco, D., Gorelli, B., Saponara, S., Lamponi, S., Gabellieri, E., Di Cesare Mannelli, L., Grillo, A., Brogi, S., Gemma, S., Maramai, S., Brindisi, M., Journal of Medicinal Chemistry, 2016, 10.1021/acs.jmedchem.5b01812

Cannabinoids: a class of unique natural products with unique pharmacology, Vincenzo Di Marzo, Fabiana Piscitelli, Rendiconti Lincei. Scienze Fisiche e Naturali, 2021, 10.1007/s12210-020-00966-y

The role of the CB₁ cannabinoid receptor and its endogenous ligands, anandamide and 2-arachidonoylglycerol, in amphetamine-induced behavioural sensitization, Hasenöhrl, R.U., Di Marzo, V., Molleman, A., Petrosino, S., van der Stelt, M., Thiemann, G., Behavioural Brain Research, 2008, 10.1016/j.bbr.2007.09.022

Polypharmacology Shakes Hands with Complex Aetiopathology, Guy, G.W., Di Marzo, V., Brodie, J.S., Trends in Pharmacological Sciences, 2015, 10.1016/j.tips.2015.08.010

Fatty acid amide hydrolase controls mouse intestinal motility in vivo, Izzo, A.A., Di Marzo, V., Valenti, M., Monory, K., Petrosino, S., Mascolo, N., Marsicano, G., Capasso, F., Borrelli, F., Lutz, B., Matias, I., Capasso, R., 2005, 10.1053/j.gastro.2005.06.018

Three-dimensional quantitative structure-selectivity relationships analysis guided rational design of a highly selective ligand for the cannabinoid receptor 2, Tafi, A., Pasquini, S., Mugnaini, C., Ligresti, A., Di Marzo, V., Corelli, F., Brogi, S., 2011, 10.1016/j.ejmech.2010.11.034

Cannabinoids and endocannabinoids in metabolic disorders with focus on diabetes, Mechoulam, R., Piscitelli, F., Di Marzo, V., 2011, 10.1007/978-3-642-17214-4-4

Oral capsaicinoid administration alters the plasma endocannabinoidome and fecal microbiota of reproductive-aged women living with overweight and obesity, Di Marzo, V., Silvestri, C., Tremblay, A., Drapeau, V., Chagnon, Y., Flamand, N., Pérusse, F., Lacroix, S., Manca, C., Biomedicines, 2021, 10.3390/biomedicines9091246

Changes in endocannabinoid and palmitoylethanolamide levels in eye tissues of patients with diabetic retinopathy and age-related macular degeneration, Di Marzo, V., Woodward, D.F., Nieves, A., Moriello, A.S., Wang, J.W., Matias, I., 2006, 10.1016/j.plefa.2006.08.002

Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes, Di Marzo, V., Stott, C.G., Petrosino, S., Bisogno, T., Allarà, M., Moriello, A.S., Ligresti, A., De Petrocellis, L., 2011, 10.1111/j.1476-5381.2010.01166.x

Impact of selenium on the intestinal microbiome-eCBome axis in the context of diet-related metabolic health in mice, Raymond, F., Di Marzo, V., Veilleux, A., Flamand, N., Martin, C., Lacroix, S., St-Arnaud, G., Bourdeau-Julien, I., Leblanc, N., Guevara Agudelo, F.A., Frontiers in Immunology, 2022, 10.3389/fimmu.2022.1028412

Evidence for an endocannabinoid system in the central nervous system of the leech Hirudo medicinalis, Salzet, M., Di Marzo, V., Breton, C., Sergheraert, C., De Petrocellis, L., Verger-Bocquet, M., Vandenbulcke, F., Melck, D., Bisogno, T., Matias, I., 2001, 10.1016/S0169-328X(00)00290-4

The CB1/VR1 agonist arvanil induces apoptosis through an FADD/caspase-8-dependent pathway, Muñoz, E., Macho, A., Di Marzo, V., Appendino, G., De La Vega, L., Sancho, R., 2003, 10.1038/sj.bjp.0705532

α-and γ-Pyrone-poly·propionates from the mediterranean ascoglossan mollusc ercolania funerea, Cimino, G., Marin, A., Di Marzo, V., Vardaro, R.R., 1992, 10.1016/S0040-4020(01)88324-1

Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells, Bifulco, M., Gazzerro, P., Campiani, G., Williams, D.C., Nathwani, S., Zisterer, D.M., Di Marzo, V., Ligresti, A., Vitale, M., Laezza, C., Casagni, A., Gemma, S., Butini, S., Pagano Zottola, A.C., Picardi, P., Pisanti, S., Proto, M.C., Fiore, D., Cancer Biology and Therapy, 2016, 10.1080/15384047.2015.1078028

Cannabinoid receptor 1 blockade ameliorates albuminuria in experimental diabetic nephropathy, Gruden, G., Perin, P.C., Rastaldi, M.P., Pinach, S., Marzo, V.D., Gambino, R., Mastrocola, R., Corbelli, A., Barutta, F., Diabetes, 2010, 10.2337/db09-1336

Anandamide enhances IL-10 production in activated microglia by targeting CB₂ receptors: Roles of ERK1/2, JNK, and NF-κB, Guaza, C., Di Marzo, V., Docagne, F., Spagnolo, A., Loría, F., Mestre, L., Hernangómez, M., Correa, F., GLIA, 2010, 10.1002/glia.20907

Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: An investigation of the 1,8-naphthyridin-2(1H)-one scaffold, Martinelli, A., MacChia, M., Giordano, A., Di Marzo, V., Bifulco, M., Rizzolio, F., Tuccinardi, T., Lucchesi, V., Ligresti, A., Laezza, C., Castelli, F., Bertini, S., Malfitano, A.M., Saccomanni, G., Manera, C., 2012, 10.1016/j.ejmech.2012.03.031

Dual therapy targeting the endocannabinoid system prevents experimental diabetic nephropathy, Gabriella Gruden, Graziella Bruno, Vincenzo di Marzo, Laura Annaratone, Alexandros Makriyannis, Kiran Vemuri, Roberto Gambino, Serena Grimaldi, Federica Barutta, Nephrology Dialysis Transplantation, 2017, 10.1093/ndt/gfx010

Arvanil, anandamide and N-arachidonoyl-dopamine (NADA) inhibit emesis through cannabinoid CB1 and vanilloid TRPV1 receptors in the ferret, Di Marzo, V., Davison, J.S., Guglielmotti, V., Pittman, Q.J., Starowicz, K., Van Sickle, M.D., Oland, L.D., Cristino, L., Sharkey, K.A., 2007, 10.1111/j.1460-9568.2007.05521.x

The role of the endocannabinoid system in skeletal muscle and metabolic adaptations to exercise: Potential implications for the treatment of obesity, Di Marzo, V., Aucouturier, J., Gamelin, F.-X., Heyman, E., 2012, 10.1111/j.1467-789X.2012.01026.x

Preface, Di Marzo, V., Cannabinoids, 2014, 10.1002/9781118451281

Palmitoylethanolamide counteracts reactive astrogliosis induced by β-amyloid peptide, Steardo, L., Di Marzo, V., Iuvone, T., Petrosino, S., De Filippis, D., Carnuccio, R., Steardo Jr., L., Arietti, P., Valenza, M., Blasio, A., Esposito, G., Scuderi, C., 2011, 10.1111/j.1582-4934.2011.01267.x

Overactivity of the intestinal endocannabinoid system in celiac disease and in methotrexate-treated rats, Di Marzo, V., Mazzarella, G., Sorrentini, I., Nigam, S., Grandone, I., Scaglione, G., Valenti, M., Gianfrani, C., Petrosino, S., D'Argenio, G., 2007, 10.1007/s00109-007-0192-3

Comparing Transgenic Production to Supplementation of ω-3 PUFA Reveals Distinct but Overlapping Mechanisms Underlying Protection Against Metabolic and Hepatic Disorders, Marette, A., Di Marzo, V., Jobin, C., Silvestri, C., Flamand, N., Lamaziere, A., Raymond, F., Levy, E., Chassaing, B., Roy, D., Barbier, O., Trottier, J., Kang, J.X., Garofalo, C., Gauthier, J., Pilon, G., Farabos, D., Julien, I.B., Varin, T.V., Mitchell, P.L., Le Barz, M., Daniel, N., Function, 2023, 10.1093/function/zqac069

Role of the endocannabinoid system in obesity induced by neuropeptide y overexpression in noradrenergic neurons, Di Marzo, V., Savontaus, E., Silvestri, C., Piscitelli, F., Kauko, T., Stormi, T., Penttinen, A.-M., Ailanen, L., Mäkelä, S., Ruohonen, S.T., Vähätalo, L.H., Nutrition and Diabetes, 2015, 10.1038/nutd.2015.1

Human lung-resident macrophages express CB1 and CB2 receptors whose activation inhibits the release of angiogenic and lymphangiogenic factors, Marone, G., Di Marzo, V., Triggiani, M., Santini, M., Varricchi, G., Fiorelli, A., Lepore, M.T., Granata, F., Secondo, A., Orlando, P., Piscitelli, F., Iannotti, F.A., Borriello, F., Loffredo, S., Staiano, R.I., Journal of Leukocyte Biology, 2016, 10.1189/jlb.3HI1214-584R

Hedonic eating in Prader–Willi syndrome is associated with blunted PYY secretion, A. Sartorio, G. Grugni, E. Lucchetti, A. De Col, F. Agosti, C. Vanetti, V. Di Marzo, A. Lauritano, F. Piscitelli, S. Bini, A. E. Rigamonti, Food & Nutrition Research, 2017, 10.1080/16546628.2017.1297553

Arylboronic acids as dual-action FAAH and TRPV1 ligands, De Petrocellis, L., Ortar, G., Nalli, M., Schiano Moriello, A., Allarà, M., Monti, L., Di Marzo, V., Morera, E., Bioorganic and Medicinal Chemistry Letters, 2016, 10.1016/j.bmcl.2016.01.071

The plant cannabinoid Δ ⁹-tetrahydrocannabivarin can decrease signs of inflammation and inflammatory pain in mice, Pertwee, R.G., Cascio, M.G., Gauson, L.A., Ross, R.A., Parolaro, D., Di Marzo, V., Marini, P., Comelli, F., Maione, S., Costa, B., Bolognini, D., British Journal of Pharmacology, 2010, 10.1111/j.1476-5381.2010.00756.x

Effect of chirality and lipophilicity in the functional activity of evodiamine and its analogues at TRPV1 channels, Di Marzo, V., Appendino, G., Passarella, D., Sacchetti, A., Fontana, G., Schiano Moriello, A., De Petrocellis, L., 2014, 10.1111/bph.12320

New resorcinol-anandamide "hybrids" as potent cannabinoid receptor ligands endowed with antinociceptive activity in vivo, Di Marzo, V., Tuccinardi, T., Pasquini, S., Martinelli, A., Maione, S., Ligresti, A., Guida, F., Corelli, F., Cascio, M.G., Brizzi, V., Brizzi, A., 2009, 10.1021/jm8016255

Cannabinoid receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database, Ruth A. Ross, Roger G. Pertwee, Raphael Mechoulam, Ken Mackie, George Kunos, Allyn C. Howlett, Miles Herkenham, Peter Greasley, Christian C. Felder, Maurice R. Elphick, Vincenzo Di Marzo, William A. Devane, Ben F. Cravatt, Pierre Casellas, Guy Cabral, Heather Bradshaw, Tom I. Bonner, Francis Barth, Stephen P.H. Alexander, Mary Abood, IUPHAR/BPS Guide to Pharmacology CITE, 2019, 10.2218/gtopdb/F13/2019.4

Disruption of the gonadal endocannabinoid system in zebrafish exposed to diisononyl phthalate, Oliana Carnevali, Vincenzo Di Marzo, Hamid R. Habibi, Fabiana Piscitelli, Alessandro Rabbito, Francesca Maradonna, Stefania Santangeli, Isabel Forner-Piquer, Environmental Pollution, 2018, 10.1016/j.envpol.2018.05.007

Editorial, Di Marzo, V., Recent Patents on CNS Drug Discovery, 2015

The emerging role of the endocannabinoidome-gut microbiome axis in eating disorders, Vincenzo Di Marzo, Giada Giorgini, Hayatte-Dounia Mir, Psychoneuroendocrinology, 2023, 10.1016/j.psyneuen.2023.106295

The Endocannabinoidome: The World of Endocannabinoids and Related Mediators, Wang, J.W., Di Marzo, V., The Endocannabinoidome: The World of Endocannabinoids and Related Mediators, 2014

Compounds acting at the endocannabinoid and/or endovanilloid systems reduce hyperkinesia in a rat model of Huntington's disease, Fernández-Ruiz, J., Di Marzo, V., Makriyannis, A., De Petrocellis, L., De Miguel, R., Lastres-Becker, I., 2003, 10.1046/j.1471-4159.2003.01595.x

Design, Synthesis and In Vitro Experimental Validation of Novel TRPV4 Antagonists Inspired by Labdane Diterpenes, De Petrocellis, L., Brizzi, A., Aiello, F., Vitale, R.M., Vega-Holm, M., Di Marzo, V., Amodeo, P., Schiano Moriello, A., Carullo, G., Mazzotta, S., Marine drugs, 2020, 10.3390/md18100519

CB1 antagonists for obesitywhat lessons have we learned from rimonabant?, Després, J.-P., Di Marzo, V., 2009, 10.1038/nrendo.2009.197

Kahweol, a natural diterpene from coffee, induces peripheral antinociception by endocannabinoid system activation, I.D.G. Duarte, T.R.L. Romero, V. Di Marzo, F. Piscitelli, A.C. Perez, M.G.M. Castor, D.P.D. Machado, R.C.M. Ferreira, C.C. Oliveira, L.S. Guzzo, Brazilian Journal of Medical and Biological Research, 2021, 10.1590/1414-431x2021e11071

Cannabinoids and Chronic Liver Diseases, Costiniuk, C.T., Jenabian, M.-A., Di Marzo, V., Sebastiani, G., Mboumba Bouassa, R.-S., International Journal of Molecular Sciences, 2022, 10.3390/ijms23169423

Evaluation of the endogenous cannabinoid system in mediating the behavioral effects of dipyrone (metamizol) in mice, Lichtman, A.H., Imming, P., Marzo, V.D., Radanova, L., Schlosburg, J.E., Behavioural Pharmacology, 2012, 10.1097/FBP.0b013e3283584794

Function of endocannabinoids and related compounds in sleep, Di Marzo, V., Prospéro-García, A., Herrera-Solís, A., Prospéro-García, O., Sleep Disorders: Diagnosis and Therapeutics, 2008

Astrocytic cannabinoid receptor 1 promotes resilience by dampening stress-induced blood-brain barrier alterations, Menard, C., Di Marzo, V., Silvestri, C., Lavoie-Cardinal, F., Mechawar, N., Turecki, G., Campbell, M., Guzman, M., Flamand, N., Manca, C., Binder, L.B., Clavet-Fournier, V., Dion-Albert, L., Kaufmann, F.N., Bouchard, J., Lavoie, O., Lebel, M., Collignon, A., Paton, S.E.J., Dudek, K.A., Research Square, 2023, 10.21203/rs.3.rs-2978353

Antithrombin Milano, single amino acid substitution at the reactive site, Arg393 to Cys, Mannucci, P.M., Tripodi, A., Morris, H.R., Panico, M., Di Marzo, V., Ireland, H., Lane, D.A., Erdjument, H., 1988

Temperature-sensitive transient receptor potential channels as ionotropic cannabinoid receptors, De Petrocellis, L., Di Marzo, V., Cannabinoid Receptors, 2013, 10.1007/978-1-4614-4669-9_8

Fishing for Targets of Alien Metabolites: A Novel Peroxisome Proliferator-Activated Receptor (PPAR) Agonist from a Marine Pest, Ernesto Mollo, Pietro Amodeo, Vincenzo Di Marzo, Francesco Regoli, Antonio Calignano, Antonio Terlizzi, Serena Felline, Fanny Defranoux, BIAGIO D'ANIELLO, Gianluca Polese, Laura Magliozzi, Laura Grauso, Adele Cutignano, Marianna Carbone, Alessandra Gentile, Tariq Fellous, Maria Elisa Giuliani, Cristoforo Silvestri, Andrea Martella, Stefania Gorbi, Enrico D'Aniello, Rosa Maria Vitale, Marine Drugs, 2018, 10.3390/md16110431

v-K-ras leads to preferential farnesylation of p21^ras in FRTL-5 cells: Multiple interference with the isoprenoid pathway, Bifulco, M., Di Marzo, V., Laezza, C., Proceedings of the National Academy of Sciences of the United States of America, 1998, 10.1073/pnas.95.23.13646

The Endocannabinoid System in Leptin-Driven Changes of Orexinergic Signaling Under Physiological and Pathological Conditions, Vincenzo Di Marzo, Letizia Palomba, Roberta Imperatore, Luigia Cristino, Endocannabinoids and Lipid Mediators in Brain Functions, 2017, 10.1007/978-3-319-57371-7_1

Adelmidrol, a palmitoylethanolamide analogue, reduces chronic inflammation in a carrageenin-granuloma model in rats, Iuvone, T., Di Marzo, V., Esposito, G., Cinelli, M.P., D'Amico, A., De Filippis, D., 2009, 10.1111/j.1582-4934.2008.00353.x

Endocannabinoids in the new millennium, Di Marzo, V., 2002, 10.1054/plef.2001.0339

Biosynthesis, structure and biological activity of hydroxyeicosatetraenoic acids in Hydra vulgaris, Cimino, G., Gianfrani, C., De Petrocellis, L., Di Marzo, V., 1993

The effect of diterpenoidic diacylglycerols on tentacle regeneration in Hydra vulgaris, Cimino, G., Minei, R., Gavagnin, M., Arcà, B., Di Marzo, V., De Petrocellis, L., 1991, 10.1016/0742-8413(91)90047-W

Functional plasticity of lipid mediators: The example of endocannabinoids, Di Marzo, V., Van der Stelt, M., De Petrocellis, L., Functional Lipidomics, 2005, 10.1201/9781420027655

Efficacy of combined therapy with fish oil and phytocannabinoids in murine intestinal inflammation, Borrelli, F., Izzo, A.A., Di Marzo, V., Venneri, T., Lucariello, G., Romano, B., Piscitelli, F., Iannotti, F.A., Pagano, E., Phytotherapy Research, 2021, 10.1002/ptr.6831

Effects of dietary fatty acids on endocannabinoid signaling in the brain and peripheral organs, Di Marzo, V., Berger, A., Abdominal Obesity and the Endocannabinoid System: From Basic Aspects to Clinical Management of Related Cardiometabolic Risk, 2008

The Gut Microbiome-Endocannabinoidome Axis: A New Way of Controlling Metabolism, Inflammation, and Behavior, Di Marzo, V., Silvestri, C., Function, 2023, 10.1093/function/zqad003

Acute naloxone-precipitated morphine withdrawal elicits nausea-like somatic behaviors in rats in a manner suppressed by N-oleoylglycine, Parker, L.A., Mechoulam, R., Lichtman, A.H., Di Marzo, V., Smoum, R., DeVuono, M.V., Wills, K.L., Gene, A., Limebeer, C.L., Ayoub, S.M., Rock, E.M., Psychopharmacology, 2020, 10.1007/s00213-019-05373-2

Deletion of the gene encoding prostamide/prostaglandin F synthase reveals an important role in regulating intraocular pressure, Overby, D.R., Watanabe, K., Inoue, Y., Sakimura, K., Yamazaki, M., Marzo, V.D., Piscitelli, F., Silvestri, C., Spenlehauer, A., Sherwood, J.M., Woodward, D.F., Bertrand, J.A., Prostaglandins Leukotrienes and Essential Fatty Acids, 2021, 10.1016/j.plefa.2020.102235

PBOX-15 induces apoptosis and improves the efficacy of oxaliplatin in human colorectal cancer cell lines, Bifulco, M., Campiani, G., Williams, D.C., Nathwani, S., Zisterer, D.M., Di Marzo, V., Ligresti, A., Vitale, M., Laezza, C., Casagni, A., Gemma, S., Butini, S., Proto, M.C., Fiore, D., Gazzerro, P., Gangemi, G., 2013, 10.1016/j.ejphar.2013.07.011

Endogenous cannabinoids in the brain and peripheral tissues: Regulation of their levels and control of food intake, Di Marzo, V., Bisogno, T., Matias, I., 2006, 10.1038/sj.ijo.0803271

Hemp seed significantly modulates the endocannabinoidome and produces beneficial metabolic effects with improved intestinal barrier function and decreased inflammation in mice under a high-fat, high-sucrose diet as compared with linseed, Silvestri, C., Di Marzo, V., Flamand, N., Martin, C., Lacroix, S., Manca, C., Ben Necib, R., Frontiers in Immunology, 2022, 10.3389/fimmu.2022.882455

Cannabimimetic eicosanoids in cancer and inflammation: An update, Di Marzo, V., Rice, A.S.C., Beaulieu, P., De Petrocellis, L., Bisogno, T., Melck, D., 2002

Neuropathic pain and the endocannabinoid system in the dorsal raphe: Pharmacological treatment and interactions with the serotonergic system, Maione, S., Rossi, F., Mangoni, G.S., Di Marzo, V., Giordano, C., Vita, D., Marabese, I., Petrosino, S., De Novellis, V., Palazzo, E., 2006, 10.1111/j.1460-9568.2006.05086.x

Erratum: PBOX-15 induces apoptosis and improves the efficacy of oxaliplatin in human colorectal cancer cell lines (European Journal of Pharmacology (2013) 714:1-3 (379-387)), Campiani, G., Bifulco, M., Clive Williams, D., Nathwani, S., Zisterer, D.M., Dimarzo, V., Ligresti, A., Vitale, M., Laezza, C., Casagni, A., Gemma, S., Butini, S., Chiara Proto, M., Fiore, D., Gazzerro, P., Gangemi, G., European Journal of Pharmacology, 2014, 10.1016/j.ejphar.2014.01.024

The endocannabinoid and endovanilloid systems and their interactions in neuropathic pain, Di Marzo, V., Rossi, F., Palazzo, E., Starowicz, K., Maione, S., 2006, 10.1002/ddr.20098

2-arachidonoyl-glycerol as an "endocannabinoid": Limelight for a formerly neglected metabolite, Di Marzo, V., 1998

Tetrahydro-β-carboline derivatives targeting fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channels, Marzo, V.D., Nalli, M., Morera, E., Allarà, M., Moriello, A.S., Petrocellis, L.D., Ortar, G., Bioorganic and Medicinal Chemistry Letters, 2013, 10.1016/j.bmcl.2012.10.137

TRPM8 indicates poor prognosis in colorectal cancer patients and its pharmacological targeting reduces tumour growth in mice by inhibiting Wnt/β-catenin signalling, Izzo, A.A., Borrelli, F., Di Marzo, V., Capasso, R., Fiorucci, S., Marchianò, S., Falco, G., Zoppoli, P., Stiuso, P., Lama, S., Lionetti, R., De Luca, M., D'Armiento, M., De Cicco, P., Cattaneo, F., Nanì, M.F., Lucariello, G., Venneri, T., Iannotti, F.A., Cicia, D., Romano, B., Pagano, E., British Journal of Pharmacology, 2023, 10.1111/bph.15960

Involvement of the cAMP/protein kinase A pathway and of mitogen- activated protein kinase in the anti-proliferative effects of anandamide in human breast cancer cells, Di Marzo, V., Guzmán, M., De Petrocellis, L., Galve-Roperh, I., Rueda, D., Melck, D., 1999, 10.1016/S0014-5793(99)01639-7

Investigations on the 4-quinolone-3-carboxylic acid motif. 2. Synthesis and structure-activity relationship of potent and selective cannabinoid-2 receptor agonists endowed with analgesic activity in vivo, Corelli, F., Di Marzo, V., Maione, S., Ligresti, A., Palazzo, E., Mugnaini, C., Semeraro, T., Botta, L., Pasquini, S., 2008, 10.1021/jm800552f

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: Beyond CB₁ and CB₂, Ross, R.A., Mechoulam, R., Mackie, K., Kunos, G., Hansen, H.S., Greasley, P.J., Elphick, M.R., Alexander, S.P.H., Di Marzo, V., Abood, M.E., Howlett, A.C., Pertwee, R.G., Pharmacological Reviews, 2010, 10.1124/pr.110.003004

Metabolic fate of endocannabinoids, Di Marzo, V., van der Stelt, M., 2004, 10.2174/1570159043476864

Pure Δ⁹-tetrahydrocannabivarin and a Cannabis sativa extract with high content in Δ⁹-tetrahydrocannabivarin inhibit nitrite production in murine peritoneal macrophages, Borrelli, F., Izzo, A.A., Marzo, V.D., Pertwee, R., Cascio, M.G., Capasso, R., Orlando, P., Pagano, E., Romano, B., Pharmacological Research, 2016, 10.1016/j.phrs.2016.07.045

Effects of curcumin and curcumin analogues on TRP channels, Luciano De Petrocellis, Vincenzo Di Marzo, Aniello Schiano Moriello, Giorgio Ortar, Marianna Nalli, Fitoterapia, 2017, 10.1016/j.fitote.2017.09.007

Isolation, characterization, and pharmacological actions of peptide histidine valine 42, a novel prepro-vasoactive intestinal peptide-derived peptide, Bloom, S.R., Morris, H.R., Panico, M., Spokes, R.A., Di Marzo, V., Yiangou, Y., 1987

The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system, Geppetti, P., Nilius, B., Appendino, G., Taglialatela-Scafati, O., Porreca, F., Dussor, G., De Petrocellis, L., Di Marzo, V., Sadofsky, L., Avonto, C., Preti, D., Andr, E., La Marca, G., De Siena, G., Benemei, S., Prenen, J., Vriens, J., Materazzi, S., Nassini, R., 2012, 10.1093/brain/awr272

Endocannabinoids in energy homeostasis and metabolic disorders, Köfalvi, A., Di Marzo, V., Matias, I., 2008, 10.1007/978-0-387-74349-3_14

Goldfish CB1 mRNA expression is affected by fasting and anandamide administration, Franzoni, M., Marzo, V.D., Campantico, E., Pomatto, V., Guastalla, A., Cottone, E., NeuroReport, 2009, 10.1097/WNR.0b013e32832a0a5f

Sex-dependent effects of neonatal maternal deprivation on endocannabinoid levels in the adipose tissue: influence of diet, Di Marzo, V., Viveros, M.P., Silvestri, C., Chowen, J., Berzal, A.L., Piscitelli, F., Mela, V., Journal of Physiology and Biochemistry, 2016, 10.1007/s13105-017-0558-0

Leukotriene release by nonpregnant human endometrium and myometrium., Turnbull, A.C., Morris, H.R., Tippins, J.R., Di Marzo, V., Rees, M.C., 1987

Cannabinoid receptor type 1 and 2 expression in the skin of healthy dogs and dogs with atopic dermatitis, Abramo, F., della Valle, M.F., Albanese, F., di Marzo, V., Cristino, L., Ricci, E., Miragliotta, V., Campora, L., 2012, 10.2460/ajvr.73.7.988

A novel prostaglandin metabolic pathway from a marine mollusc: prostaglandin-1,15-lactones., Villani, G., Spinella, A., Sodano, G., Cimino, G., Di Marzo, V., 1991

Synthesis, conformational analysis and CB₁ binding affinity of hairpin-like anandamide pseudopeptide mimetics, Gomez-Paloma, L., Riccio, R., Di Marzo, V., Ligresti, A., Cimino, P., Bifulco, G., Casapullo, A., Di Marzo, M., Journal of Peptide Science, 2006, 10.1002/psc.754

The endocannabinoid system for the development of new drugs for spasticity, Di Marzo, V., 2007, 10.1358/dof.2007.032.04.1083482

Orexin induces the production of an endocannabinoid-derived lysophosphatidic acid eliciting hypothalamic synaptic loss in obesity, Cristino, L., Di Marzo, V., Di Costanzo, A., Imperatore, R., Piscitelli, F., Tunisi, L., Palomba, L., Forte, N., Fernández-Rilo, A.C., Molecular Metabolism, 2023, 10.1016/j.molmet.2023.101713

Gestational Diabetes Mellitus, Human Milk Composition, and Infant Growth, Robitaille, J., Veilleux, A., Doyen, A., Di Marzo, V., Marc, I., Leblanc, N., Perreault, V., Richard, V., St-Arnaud, G., Perron, J., Laberee, L., Dugas, C., Breastfeeding Medicine, 2023, 10.1089/bfm.2022.0085

Discovery of glycine sulfonamides as dual inhibitors of sn-1-diacylglycerol lipase α and α/β-hydrolase domain 6, Van Der Stelt, M., Overkleeft, H.S., Di Marzo, V., McGuire, R., Van Esbroeck, A.C.M., Ligresti, A., Den Dulk, H., Van Der Wel, T., Allarà, M., Baggelaar, M.P., Deng, H., Janssen, F.J., 2014, 10.1021/jm500681z

Some like it pungent and vile. TRPA1 as a molecular target for the malodorous vinyl disulfides from asafoetida, Taglialatela-Scafati, O., Soltani, R., Fattahian, K., Taghvayi, R., Ghannadi, A., De Petrocellis, L., Di Marzo, V., Appendino, G., Chianese, G., Shokoohinia, Y., 2013, 10.1016/j.fitote.2013.08.001

Changes in endocannabinoid levels in a rat model of behavioural sensitization to morphine, Rubino, T., Parolaro, D., Di Marzo, V., Cascio, M.G., Valenti, M., Viganò, D., 2004, 10.1111/j.1460-9568.2004.03645.x

Human leukocytes differentially express endocannabinoid‐glycerol lipases and hydrolyze 2‐arachidonoyl‐glycerol and its metabolites from the 15‐lipoxygenase and cyclooxygenase pathways, Nicolas Flamand, Vincenzo Di Marzo, Michel Laviolette, Louis‐Philippe Boulet, Élyse Bissonnette, Marie‐Renée Blanchet, Cyril Martin, Anne‐Sophie Archambault, Élizabeth Dumais, Caroline Turcotte, Journal of Leukocyte Biology, 2019, 10.1002/jlb.3a0919-049rrr

Antiepileptic action of N-palmitoylethanolamine through CB1 and PPAR-α receptor activation in a genetic model of absence epilepsy, De Sarro, G., Calignano, A., Di Marzo, V., Maione, S., Van Luijtelaar, G., Gatta, L., Guida, F., Petrosino, S., D'Agostino, G., Russo, R., Avagliano, C., Cosco, D., Van Rijn, C.M., Scicchitano, F., Russo, E., Citraro, R., 2013, 10.1016/j.neuropharm.2012.11.017

Role and regulation of acylethanolamides in energy balance: Focus on adipocytes and β-cells, Di Marzo, V., Izzo, A.A., Roche, R., Monteleone, P., Hoareau, L., Capasso, R., Docimo, L., Petrosino, S., Gonthier, M.-P., Matias, I., 2007, 10.1038/sj.bjp.0707424

Anandamide inhibits adhesion and migration of breast cancer cells, Bifulco, M., Di Marzo, V., Portella, G., Iacuzzo, I., Notarnicola, M., Caruso, M.G., Vitale, M., Santoro, A., Malfitano, A.M., Laezza, C., Pisanti, S., Grimaldi, C., 2006, 10.1016/j.yexcr.2005.10.024

Critical role of the endogenous cannabinoid system in mouse pup suckling and growth, Mechoulam, R., Di Marzo, V., Bisogno, T., Breuer, A., Ginzburg, Y., Fride, E., 2001, 10.1016/S0014-2999(01)00953-0

The endocannabinoid system is modulated in response to spinal cord injury in rats, Molina-Holgado, E., Di Marzo, V., Guaza, C., Watanabe, M., Bisogno, T., Hagen, C., Docagne, F., Petrosino, S., Arevalo-Martin, A., Garcia-Ovejero, D., 2009, 10.1016/j.nbd.2008.09.015

Anandamide uptake by human endothelial cells and its regulation by nitric oxide, Finazzi-Agrò, A., Di Marzo, V., Bisogno, T., Lorenzon, T., Bari, M., Maccarrone, M., 2000, 10.1074/jbc.275.18.13484

In Silico Identification and Experimental Validation of (−)-Muqubilin A, a Marine Norterpene Peroxide, as PPARα/γ-RXRα Agonist and RARα Positive Allosteric Modulator, ROSA MARIA VITALE, Pietro Amodeo, Vincenzo Di Marzo, Joshua Waxman, Margherita Gavagnin, Maria Letizia Ciavatta, Fabrizia De Maio, Alessandra Gentile, Andrea Martella, Lauren G. Falkenberg, Fabio Arturo Iannotti, Enrico D’Aniello, Marine Drugs, 2019, 10.3390/md17020110

Differential alterations of the concentrations of endocannabinoids and related lipids in the subcutaneous adipose tissue of obese diabetic patients, Di Marzo, V., Rivellese, A.A., Petrosino, S., Verde, R., Riccardi, G., Bozzetto, L., Costabile, G., Giacco, R., Patti, L., Di Marino, L., Piscitelli, F., Annuzzi, G., 2010, 10.1186/1476-511X-9-43

Altered endocannabinoid signalling after a high-fat diet in Apoe ^-/- mice: Relevance to adipose tissue inflammation, hepatic steatosis and insulin resistance, Di Marzo, V., Heeren, J., Scheja, L., Toedter, K., Ligresti, A., Mele, C., Orlando, P., Bartelt, A., Diabetologia, 2011, 10.1007/s00125-011-2274-6

Identification of a New Class of Molecules, the Arachidonyl Amino Acids, and Characterization of One Member That Inhibits Pain, Walker, J.M., Di Marzo, V., Burstein, S., De Petrocellis, L., Maeda, D.Y., Coop, A., Sivakumar, R., Zipkin, R.E., Zavitsanos, P.A., Chang, S.Y., Petros, T.J., Bisogno, T., Huang, S.M., 2001, 10.1074/jbc.M107351200

Peripubertal cannabidiol treatment rescues behavioral and neurochemical abnormalities in the MAM model of schizophrenia, Vincenzo Micale, Vincenzo Di Marzo, Raphael Mechoulam, Filippo Drago, Zenon Starcuk, Carsten T. Wotjak, Mauro Maccarrone, Alexandra Sulcova, Salvatore Salomone, Martina Di Bartolomeo, Giovanni Giurdanella, Zuzana Babinska, Monica Bari, Fabiana Piscitelli, Eva Drazanova, Vladimir Pekarik, Claudio D'Addario, Roberta Di Marco, Fabio Arturo Iannotti, Jana Ruda-Kucerova, Tibor Stark, Neuropharmacology, 2019, 10.1016/j.neuropharm.2018.11.035

The Expanded Endocannabinoid System/Endocannabinoidome as a Potential Target for Treating Diabetes Mellitus, Silvestri, C., Di Marzo, V., Veilleux, A., Current Diabetes Reports, 2019, 10.1007/s11892-019-1248-9

Chalcone derivatives activate and desensitize the transient receptor potential ankyrin 1 cation channel, subfamily A, member 1 TRPA1 ion channel: Structure-activity relationships in vitro and anti-nociceptive and anti-inflammatory activity in vivo, De Petrocellis, L., Di Marzo, V., Passarella, D., Maione, S., Perdicchia, D., Christodoulou, M.S., Guida, F., Luongo, L., Moriello, A.S., CNS and Neurological Disorders - Drug Targets, 2016, 10.1016/j.ienj.2015.05.007

Enantioselective synthesis of 1-(R)-hydroxypolygodial and its 9α epimer, 1-(R)-hydroxyisotadeonal, Spinella, A., di Marzo, V., De Petrocellis, L., Izzo, I., Della Sala, G., Della Monica, C., 2007, 10.1016/j.tet.2007.04.059

Genetic deletion of monoacylglycerol lipase leads to impaired cannabinoid receptor CB1R signaling and anxiety-like behavior, Cristino, L., Di Marzo, V., Maione, S., Belardo, C., De Gregorio, D., Romano, R., Taschler, U., Luongo, L., Morello, G., Imperatore, R., Journal of Neurochemistry, 2015, 10.1111/jnc.13267

Endocannabinoids and multiple sclerosis: A blessing from the 'inner bliss'?, De Petrocellis, L., Bifulco, M., Di Marzo, V., 2000, 10.1016/S0165-6147(00)01487-5

Obesity Affects the Microbiota–Gut–Brain Axis and the Regulation Thereof by Endocannabinoids and Related Mediators, Luigia Cristino, Vincenzo Di Marzo, Letizia Palomba, Alba Clara Fernández-Rilo, Nicola Forte, International Journal of Molecular Sciences, 2020, 10.3390/ijms21051554

Possible involvement of arachidonic acid and eicosanoids in metamorphic events in Hydractinia echinata (Coelenterata; hydrozoa), Di Marzo, V., De Petrocellis, L., Lehmann, W.D., Stephan, M., Beck, H., Leitz, T., Journal of Experimental Zoology, 1994, 10.1002/jez.1402690505

Peripheral effects of the endocannabinoid system in energy homeostasis: Adipose tissue, liver and skeletal muscle, Di Marzo, V., Ligresti, A., Silvestri, C., 2011, 10.1007/s11154-011-9167-3

Basal and fasting/refeeding-regulated tissue levels of endogenous PPAR-α ligands in zucker rats, Di Marzo, V., Petrosino, S., Cristino, L., Marini, P., Capasso, R., Piscitelli, F., Izzo, A.A., 2010, 10.1038/oby.2009.186

Cannabinoid receptors and endocannabinoids: Role in neuroinflammatory and neurodegenerative disorders, Di Marzo, V., Bisogno, T., 2010

Palmitoylethanolamide enhances anandamide stimulation of human vanilloid VR1 receptors, Di Marzo, V., Davis, J.B., De Petrocellis, L., 2001, 10.1016/S0014-5793(01)02934-9

Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide, Högestätt, E.D., Julius, D., Di Marzo, V., Sørgård, M., Chuang, H.-H., Andersson, D.A., Petersson, J., Zygmunt, P.M., 1999, 10.1038/22761

Fifty years of 'cannabinoid research' and the need for a new nomenclature, De Petrocellis, L., Di Marzo, V., Cannabinoids, 2014, 10.1002/9781118451281.ch8

Leukotriene release by endometrium and myometrium throughout the menstrual cycle in dysmenorrhoea and menorrhagia, Turnbull, A.C., Morris, H.R., Tippins, J.R., DiMarzo, V., Rees, M.C., Journal of Endocrinology, 1987, 10.1677/joe.0.1130291

Circulating and hepatic endocannabinoids and endocannabinoid-related molecules in patients with cirrhosis, Di Marzo, V., Bernardi, M., Zoli, M., Golfieri, R., Grazi, G., Riili, A., Giampalma, E., Petrosino, S., Domenicali, M., Cescon, M., Berzigotti, A., Giannone, F., Piscitelli, F., Viola, A., Caraceni, P., 2010, 10.1111/j.1478-3231.2009.02137.x

Arvanil-induced inhibition of spasticity and persistent pain: Evidence for therapeutic sites of action different from the vanilloid VR1 receptor and cannabinoid CB₁/CB₂ receptors, Baker, D., Di Marzo, V., Rice, A.S.C., Bifulco, M., Ledent, C., Bridges, D., Brown, P., Hankey, D.J.R., Jaggar, S.I., Bisogno, T., Pryce, G., Brooks, J.W., European Journal of Pharmacology, 2002, 10.1016/S0014-2999(02)01369-9

Influence of diet on acute endocannabinoidome mediator levels post exercise in active women, a crossover randomized study, Raymond, F., Di Marzo, V., Billaut, F., Veilleux, A., Flamand, N., Lamarche, B., Perron, J., Martin, C., Feutry, P., Rakotoarivelo, V., Parent, L., Rochefort, G., Guevara Agudelo, F.A., Nguyen, G.Q., Bourdeau-Julien, I., Forteza, F., Scientific Reports, 2022, 10.1038/s41598-022-10757-0

The endogenous cannabimimetic eicosanoid, anandamide, induces arachidonate release in J774 mouse macrophages, Maurelli, S., Bisogno, T., De Petrocellis, L., Di Marzo, V., 1996

Association between the FAAH C385A variant (rs324420) and obesity-related traits: a systematic review, Barbara Vizmanos, Vincenzo Di Marzo, Erika Martinez-Lopez, Erika Sierra-Ruelas, Francisco Trujillo-Sánchez, Oscar David Lopez-Cortes, International Journal of Obesity, 2024, 10.1038/s41366-023-01428-9

Fetal endocannabinoids orchestrate the organization of pancreatic islet microarchitecture, Harkany, T., Dobrzyn, A., Hökfelt, T.G.M., Marzo, V.D., Mackie, K., Björklund, P., Calvigioni, D., Piscitelli, F., Keimpema, E., Malenczyk, K., Proceedings of the National Academy of Sciences of the United States of America, 2015, 10.1073/pnas.1519040112

The gut microbiome, endocannabinoids and metabolic disorders, Di Marzo, V., Iannotti, F.A., Journal of Endocrinology, 2021, 10.1530/JOE-20-0444

TRPV1 in Neuropathic Pain and Neurological and Neuropsychiatric Disorders, Di Marzo, V., Maione, S., Starowicz, K., Palazzo, E., 2010, 10.1002/9780470588284.ch10

Chronic exposure to cannabinoids during adolescence causes long-lasting behavioral deficits in adult mice, Havemann-Reinecke, U., Di Marzo, V., Hoyer-Fender, S., Piscitelli, F., Agis-Balboa, R.C., Benito, E., Tomas-Roig, J., Addiction Biology, 2017, 10.1111/adb.12446

Bradykinin- and chemotactic peptide fMLP-stimulated leukotriene biosynthesis in rat lungs and its inhibition by vasoactive intestinal peptide, Morris, H.R., Tippins, J.R., Di Marzo, V., 1988

Cannabinoid receptors in GtoPdb v.2023.1, Ruth A. Ross, Roger G. Pertwee, Raphael Mechoulam, Ken Mackie, George Kunos, Allyn C. Howlett, Miles Herkenham, Peter Greasley, Christian C. Felder, Maurice R. Elphick, Vincenzo Di Marzo, William A. Devane, Ben F. Cravatt, Pierre Casellas, Guy Cabral, Heather Bradshaw, Tom I. Bonner, Francis Barth, Stephen P.H. Alexander, Mary Abood, IUPHAR/BPS Guide to Pharmacology CITE, 2023, 10.2218/gtopdb/F13/2023.1

Hepatic NAPE-PLD Is a Key Regulator of Liver Lipid Metabolism, Patrice D. Cani, Giulio G. Muccioli, Cristoforo Silvestri, Serge Luquet, Nicolas Flamand, Vincenzo Di Marzo, Nathalie M. Delzenne, Isabelle Leclercq, Rita Manco, Marialetizia Rastelli, Matthias Van Hul, Martin Roumain, Charlotte Lefort, Cells, 2020, 10.3390/cells9051247

Levels, metabolism, and pharmacological activity of anandamide in CB₁ cannabinoid receptor knockout mice: Evidence for non-CB₁, non-CB₂ receptor-mediated actions of anandamide in mouse brain, Martin, B.R., Zimmer, A., Zimmer, A.M., Razdan, R.K., Bridgen, D.T., Tao, Q., Breivogel, C.S., Di Marzo, V., Journal of Neurochemistry, 2000, 10.1046/j.1471-4159.2000.0752434.x

Short-term supplementation with ω-3 polyunsaturated fatty acids modulates primarily mucolytic species from the gut luminal mucin niche in a human fermentation system, Silvestri, C., Di Marzo, V., Desjardins, Y., Plante, P.-L., Anunciação Braga Guebara, S., Roussel, C., Gut Microbes, 2022, 10.1080/19490976.2022.2120344

The novel endogenous cannabinoid 2-arachidonoylglycerol is inactivated by neuronal- and basophil-like cells: Connections with anandamide, De Petrocellis, L., Melck, D., Sugiura, T., Bisogno, T., Di Marzo, V., 1998

Cannabinoids and schizophrenia: Therapeutic prospects, Guy, G.W., Di Marzo, V., Robson, P.J., 2014, 10.2174/13816128113199990427

New analgesics synthetically derived from the paracetamol metabolite N-(4-hydroxyphenyl)-(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-enamide, Imming, P., Di Marzo, V., Ligresti, A., Ott, I., Nüsing, R.M., Coste, O., Watzer, B., Sinning, C., 2008, 10.1021/jm800807k

Methods for measuring endocannabinoid production and expression and activity of enzymes involved in the endocannabinoid system, Di Marzo, V., De Petrocellis, L., Bisogno, T., Lipid-Mediated Signaling, 2010, 10.1201/9780849381423

Abdominal obesity and the endocannabinoid system: From basic aspects to clinical management of related cardiometabolic risk, Di Marzo, V., Després, J.-P., Abdominal Obesity and the Endocannabinoid System: From Basic Aspects to Clinical Management of Related Cardiometabolic Risk, 2008

Normal human pituitary gland and pituitary adenomas express cannabinoid receptor type 1 and synthesize endogenous cannabinoids: First evidence for a direct role of cannabinoids on hormone modulation at the human pituitary level, Stalla, G.K., Lutz, B., Di Marzo, V., Losa, M., Milone, A., Arzberger, T., Stalla, J., Grübler, Y., Theodoropoulou, M., Fezza, F., Marsicano, G., Pagotto, U., 2001, 10.1210/jc.86.6.2687

The endovanilloid/endocannabinoid system in human osteoclasts: Possible involvement in bone formation and resorption, Maione, S., Di Marzo, V., Perrotta, S., Nobili, B., Santoro, C., Torella, M., Petrosino, S., Bellini, G., De Petrocellis, L., Luongo, L., Siniscalco, D., Rossi, F., 2009, 10.1016/j.bone.2008.10.056

The time course of erythrocyte membrane fatty acid concentrations during and after treatment of non-human primates with increasing doses of an omega-3 rich phospholipid preparation derived from krill-oil, Yong-Fu Xiao, Vincenzo Di Marzo, Fabiana Piscitelli, Xiaoli Wang, Petter-Arnt Hals, Lipids in Health and Disease, 2017, 10.1186/s12944-017-0414-9

Comments on Disruption of the gonadal endocannabinoid system in zebrafish exposed to diisononyl phthalate – Forner-Piquer et al. (2018)”: rebuttal to Prosser CM., Carnevali, O., di Marzo, V., Habibi, H.R., Piscitelli, F., Rabbito, A., Maradonna, F., Santangeli, S., Forner-Piquer, I., Environmental Pollution, 2020, 10.1016/j.envpol.2020.114028

Human and mouse eosinophils differ in their ability to biosynthesize eicosanoids, docosanoids, the endocannabinoid 2-arachidonoyl-glycerol and its congeners, Flamand, N., Blanchet, M.-R., Boulet, L.-P., Laviolette, M., Di Marzo, V., Martin, C., Bernatchez, É., Brassard, J., Archambault, A.-S., Cells, 2022, 10.3390/cells11010141

The dual blocker of FAAH/TRPV1 N-arachidonoylserotonin reverses the behavioral despair induced by stress in rats and modulates the HPA-axis, Di Marzo, V., Drago, F., Leggio, G.M., Imperatore, R., Verde, R., Gozzo, L., Camillieri, G., Micale, V., Iannotti, F.A., Tamburella, A., Navarria, A., 2014, 10.1016/j.phrs.2014.04.014

β-Endorphin in Neoroblastoma x Glioma hybrid cells, Palmisano, A., Morris, H.R., Marino, G., Etienne, A., Di Marzo, V., 1985, 10.1016/0143-4179(85)90130-1

New N-arachidonoylserotonin analogues with potential "dual" mechanism of action against pain, Di Marzo, V., Maione, S., Woodward, D.F., De Novellis, V., Nalli, M., Schiano-Moriello, A., Rossi, F., Morera, E., De Petrocellis, L., Cascio, M.G., Ortar, G., 2007, 10.1021/jm070678q

Design, synthesis, and binding studies of new potent ligands of cannabinoid receptors, Marzo, V.D., Sirianni, R., Bisogno, T., Cascio, M.G., Brizzi, V., Brizzi, A., Journal of Medicinal Chemistry, 2005, 10.1021/jm0501533

Metabolism of anandamide and 2-arachidonoylglycerol: An historical overview and some recent developments, Melck, D., Bisogno, T., De Petrocellis, L., Di Marzo, V., 1999

Potential biosynthetic connections between the two cannabimimetic eicosanoids, anandamide and 2-arachidonoyl-glycerol, in mouse neuroblastoma cells, Waku, K., Sugiura, T., De Petrocellis, L., Marzo Di, V., 1996, 10.1006/bbrc.1996.1501

RIA/chromatographic evidence for novel opioid peptide(s) in Squilla mantis ganglia, Tomlin, S., Howlett, T.A., Morris, H.R., Di Marzo, V., Marino, G., Palmisano, A., 1986, 10.1016/0143-4179(86)90022-3

Endocannabinoids and fatty acid amides in cancer, inflammation and related disorders, Di Marzo, V., Bisogno, T., Melck, D., De Petrocellis, L., 2000, 10.1016/S0009-3084(00)00196-1

2-Pentadecyl-2-oxazoline ameliorates memory impairment and depression-like behaviour in neuropathic mice: possible role of adrenergic alpha2- and H3 histamine autoreceptors, Luongo, L., Maione, S., Di Marzo, V., Calignano, A., Palazzo, E., Paino, S., de Novellis, V., Belardo, C., Marabese, I., Amodeo, P., Vitale, R.M., Cristiano, C., Ricciardi, F., Infantino, R., Iannotti, F.A., Iannotta, M., Guida, F., Boccella, S., Molecular Brain, 2021, 10.1186/s13041-020-00724-z

Functional lipidomics. Calcium-independent activation of endocannabinoid/endovanilloid lipid signalling in sensory neurons by protein kinases C and A and thrombin, Di Marzo, V., McNaughton, P.A., Magherini, P.C., Prandini, M., Valenti, M., De Petrocellis, L., Petrosino, S., Vellani, V., 2008, 10.1016/j.neuropharm.2008.01.010

Iron overload causes osteoporosis in thalassemia major patients through interaction with transient receptor potential vanilloid type 1 (TRPV1) channels, Maione, S., Di Marzo, V., Nobili, B., Torella, M., Francese, M., Siniscalco, D., Tortora, C., Luongo, L., Bellini, G., Perrotta, S., Rossi, F., 2014, 10.3324/haematol.2014.104463

Arachidonic acid as an endogenous signal for the glutathione-induced feeding response in Hydra, Di Marzo, V., Minei, R., De Petrocellis, L., Pierobon, P., 1997, 10.1007/PL00000580

Phosphatidic acid as the biosynthetic precursor of the endocannabinoid 2-arachidonoylglycerol in intact mouse neuroblastoma cells stimulated with ionomycin, Di Marzo, V., De Petrocellis, L., Melck, D., Bisogno, T., 1999, 10.1046/j.1471-4159.1999.0722113.x

The administration of endocannabinoid uptake inhibitors OMDM-2 or VDM-11 promotes sleep and decreases extracellular levels of dopamine in rats, Di Marzo, V., Millán-Aldaco, D., Palomero-Rivero, M., Murillo-Rodríguez, E., 2013, 10.1016/j.physbeh.2012.11.007

Erratum: Anandamide and diet: Inclusion of dietary arachidonate and docosahexaenoate leads to increased brain levels of the corresponding N-acylethanolamines in piglets (Proceedings of the National Academy of Sciences of the United States of America (May 22, 2001) 98:11 (6402-6406)), Di Marzo, V., Innis, S., Cavaliere, P., Bisogno, T., Crozier, G., Berger, A., 2001

Inhibition of basal and ultraviolet B-induced melanogenesis by cannabinoid CB₁ receptors: A keratinocyte-dependent effect, Vieira-Coelho, M.A., Di Marzo, V., Petrosino, S., Moura, D., Serrão, M.P., Moura, E., Esteves-Pinto, C., Magina, S., Archives of Dermatological Research, 2011, 10.1007/s00403-011-1126-z

Dietary food patterns as determinants of the gut microbiome–endocannabinoidome axis in humans, Veilleux, A., Di Marzo, V., Raymond, F., Lamarche, B., Flamand, N., Perron, J., Castonguay-Paradis, S., Scientific Reports, 2023, 10.1038/s41598-023-41650-z

Plant, synthetic, and endogenous cannabinoids in medicine, De Petrocellis, L., Di Marzo, V., 2006, 10.1146/annurev.med.57.011205.135648

PAF-mediated leukotriene biosynthesis in lungs : Control by the neuropeptidergic system, Morris, H.R., Tippins, J.R., Di Marzo, V., 1987, 10.1016/0090-6980(87)90228-0

Regulation of endocannabinoid levels under physiological and pathological conditions. A mini-review, Marzo, V.D., Pharmacy and Pharmacology Communications, 2000, 10.1211/146080800128736006

Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons, Van Der Stelt, M., Cravatt, B.F., Werkman, T.R., Hankemeier, T., Overkleeft, H.S., Kruse, C.G., Wadman, W.J., Di Marzo, V., Florea, B.I., Allarà, M., Den Dulk, H., Deng, H., Soethoudt, M., Van Der Wel, T., Janssen, F., Hsu, K.-L., Hummel, J., Kantae, V., Chameau, P.J.P., Baggelaar, M.P., Journal of the American Chemical Society, 2015, 10.1021/jacs.5b04883

Protective activation of the endocannabinoid system during ischemia in dopamine neurons, Pistis, M., Di Marzo, V., Marsicano, G., Gessa, G.L., Lutz, B., Muntoni, A.L., Perra, S., Petrosino, S., Minassi, A., Bisogno, T., Pillolla, G., Melis, M., 2006, 10.1016/j.nbd.2006.04.010

An NMR spectroscopic method to identify and classify thiol-trapping agents: Revival of michael acceptors for drug discovery?, Appendino, G., De-Petrocellis, L., Di-Marzo, V., Minassi, A., Pollastro, F., Taglialatela-Scafati, O., Avonto, C., 2011, 10.1002/anie.201005959

Responses of peripheral endocannabinoids and endocannabinoid-related compounds to hedonic eating in obesity, Maj, M., Calugi, S., Volpe, U., Piscitelli, F., Ghoch, M.E., Aveta, T., Dalle Grave, R., Monteleone, P., Di Marzo, V., Monteleone, A.M., European Journal of Nutrition, 2016, 10.1007/s00394-016-1153-9

Cannabis use in relation to Pulse Pressure and Mean Arterial Pressure in US Adults, Ngueta, G., Marzo, V.D., Ruddy, S., medRxiv, 2023, 10.1101/2023.05.12.23289921

Anandamide may mediate sleep induction [6], Vogel, Z., Bayewitch, M., Marzo, V.D., Bisogno, T., Sheskin, T., Hanuš, L., Fride, E., Mechoulam, R., Nature, 1997, 10.1038/37891

The anti-inflammatory mediator palmitoylethanolamide enhances the levels of 2-arachidonoyl-glycerol and potentiates its actions at TRPV1 cation channels, Di Marzo, V., De Petrocellis, L., Puigdemont, A., Fusco, M., Cerrato, S., Schiano Moriello, A., Petrosino, S., British Journal of Pharmacology, 2016, 10.1111/bph.13084

Platelet-rich plasma exerts antinociceptive activity by a peripheral endocannabinoid-related mechanism, Di Marzo, V., Maione, S., Gatta, L., Guida, F., Luongo, L., Piscitelli, F., Cancedda, R., Ulivi, V., Descalzi, F., 2013, 10.1089/ten.tea.2012.0557

Increased endocannabinoid levels reduce the development of precancerous lesions in the mouse colon, Di Marzo, V., Capasso, F., Nigam, S., Capasso, R., Borrelli, F., Lutz, B., Marsicano, G., Orlando, P., Petrosino, S., Aviello, G., Izzo, A.A., 2008, 10.1007/s00109-007-0248-4

Phytocannabinoids beyond the Cannabis plant - Do they exist?, Di Marzo, V., Pertwee, R.G., Gertsch, J., 2010, 10.1111/j.1476-5381.2010.00745.x

Discovery of novel Tetrahydrobenzo[b]thiophene and pyrrole based scaffolds as potent and selective CB2 receptor ligands: The structural elements controlling binding affinity, selectivity and functionality, Abadi, A.H., Abouzid, K.A., Di Marzo, V., Rabbito, A., Allarà, M., Klein, C.D., Ligresti, A., Osman, N.A., European Journal of Medicinal Chemistry, 2016, 10.1016/j.ejmech.2016.07.012

Investigations on the 4-Quinolone-3-Carboxylic Acid Motif Part5: Modulation of the Physicochemical Profile of a Set of Potent and Selective Cannabinoid-2 Receptor Ligands through a Bioisosteric Approach, Corelli, F., DiMarzo, V., Maione, S., Moaddel, R., Pertwee, R.G., Cascio, M.G., Bolognini, D., Rosenberg, A., Ligresti, A., Dragoni, S., Luongo, L., Guida, F., Valoti, M., Bellucci, L., DeChiaro, M., Tafi, A., Pasquini, S., Pedani, V., Nocerino, S., Mugnaini, C., ChemMedChem, 2012, 10.1002/cmdc.201100573

Are cannabidiol and Δ⁹-tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review, Pertwee, R.G., Di Marzo, V., Duncan, M., McPartland, J.M., British Journal of Pharmacology, 2015, 10.1111/bph.12944

Non-CB₁, Non-CB₂ receptors for endocannabinoids, plant cannabinoids, and synthetic cannabimimetics: Focus on G-protein-coupled receptors and transient receptor potential channels, Di Marzo, V., De Petrocellis, L., Journal of Neuroimmune Pharmacology, 2010, 10.1007/s11481-009-9177-z

Rational design, synthesis, and pharmacological properties of new 1,8-naphthyridin-2(1H)-on-3-carboxamide derivatives as highly selective cannabinoid-2 receptor agonists, Ferrarini, P.L., Di Marzo, V., Masini, E., Nieri, P., Martinelli, A., Lucchesi, V., Tuccinardi, T., Cascio, M.G., Ligresti, A., Benetti, V., Adinolfi, B., Saccomanni, G., Manera, C., 2009, 10.1021/jm801563d

DAG lipase involvement in depolarization-induced suppression of inhibition: Does endocannabinoid biosynthesis always meet the demand?, Mansvelder, H.D., Di Marzo, V., Min, R., 2010, 10.1177/1073858410373281

Regulation and possible role of endocannabinoids and related mediators in hypercholesterolemic mice with atherosclerosis, Di Marzo, V., Steffens, S., Mach, F., Braunersreuther, V., Pelli, G., Burger, F., Petrosino, S., Lenglet, S., Matias, I., Montecucco, F., 2009, 10.1016/j.atherosclerosis.2008.12.040

Suppression of nerve growth factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell proliferation, Marzo, V.D.I., Bifulco, M., Laezza, C., Bisogno, T., Orlando, P., De Petrocellis, L., Melck, D., Endocrinology, 2000, 10.1210/endo.141.1.7239

The role of endocannabinoids in the regulation of gastric emptying: Alterations in mice fed a high-fat diet, Izzo, A.A., Capasso, F., Orlando, P., Romano, B., Borrelli, F., Petrosino, S., Aviello, G., Matias, I., Capasso, R., Di Marzo, V., 2008, 10.1038/sj.bjp.0707682

The endocannabinoid system mediates aerobic exercise-induced antinociception in rats, Perez, A.C., Di Marzo, V., Duarte, I.D., Piscitelli, F., Parrella, C., Cruz, J.S., De Paula, A.M., Aguiar, D.C., Silva, J.F.P., Romero, T.R.L., Galdino, G., 2014, 10.1016/j.neuropharm.2013.09.022

Allodynia Lowering Induced by Cannabinoids and Endocannabinoids (ALICE), Vincenzo Di Marzo, Sabatino Maione, Katarzyna Starowicz, Livio Luongo, Pharmacological Research, 2017, 10.1016/j.phrs.2017.02.019

The endocannabinoid system and its therapeutic exploitation, De Petrocellis, L., Bifulco, M., Di Marzo, V., 2004, 10.1038/nrd1495

Early Blockade of CB1 Receptors Ameliorates Schizophrenia-like Alterations in the Neurodevelopmental MAM Model of Schizophrenia, Vincenzo Micale, Vincenzo Di Marzo, Filippo Drago, Claudio D’Addario, Carsten T. Wotjak, Fabiana Piscitelli, Jana Ruda-Kucerova, Martina Di Bartolomeo, Serena Di Martino, Fabio Arturo Iannotti, Tibor Stark, Biomolecules, 2022, 10.3390/biom12010108

Modulation of mouse gastrointestinal motility by allyl isothiocyanate, a constituent of cruciferous vegetables (Brassicaceae): Evidence for TRPA1-independent effects, Izzo, A.A., Di Marzo, V., De Petrocellis, L., Borrelli, F., Romano, B., Aviello, G., Capasso, R., 2012, 10.1111/j.1476-5381.2011.01703.x

Bioactive prenylogous cannabinoid from fiber hemp (Cannabis sativa), Appendino, G., De Petrocellis, L., Di Marzo, V., Muñoz, E., Allarà, M., Taglialatela-Scafati, O., Pollastro, F., 2011, 10.1021/np200500p

Primary Structure of Neuromedin U from the Rat, Morris, H.R., DiMarzo, V., Thim, L., Bloom, S.R., Morris, H.R., DiMarzo, V., Thim, L., Domin, J., Conlon, J.M., Journal of Neurochemistry, 1988, 10.1111/j.1471-4159.1988.tb01837.x

Analysis of the "endocannabinoidome" in peripheral tissues of obese Zucker rats, Di Marzo, V., Capasso, R., Parrella, C., Palmieri, V., Allarà, M., Mazzarella, E., Martella, A., Piscitelli, F., Iannotti, F.A., 2013, 10.1016/j.plefa.2013.06.002

Dysregulation of peripheral endocannabinoid levels in hyperglycemia and obesity: Effect of high fat diets, Di Marzo, V., Izzo, A.A., Capasso, R., Racioppi, A., Petrosino, S., Matias, I., 2008, 10.1016/j.mce.2008.01.026

Role of insulin as a negative regulator of plasma endocannabinoid levels in obese and nonobese subjects, Taskinen, M.-R., Van Gaal, L., Matias, I., Soro-Paavonen, A., Westerbacka, J., Piscitelli, F., Lundbom, N., Mertens, I., Petrosino, S., Hakkarainen, A., Verrijken, A., Di Marzo, V., 2009, 10.1530/EJE-09-0643

Endocannabinoids and the control of energy balance, Di Marzo, V., Matias, I., 2007, 10.1016/j.tem.2006.11.006

Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 7. Synthesis and Pharmacological Evaluation of 4-Quinolone-3-carboxamides and 4-Hydroxy-2-quinolone-3-carboxamides as High Affinity Cannabinoid Receptor 2 (CB2R) Ligands with Improved Aqueous Solubility, Corelli, F., Di Marzo, V., Mor, M., Silva, C., Vacondio, F., Lamponi, S., Allarà, M., Ligresti, A., Brizzi, A., Mugnaini, C., Journal of Medicinal Chemistry, 2016, 10.1021/acs.jmedchem.5b01559

Arvanil, a hybrid endocannabinoid and vanilloid compound, behaves as an antihyperkinetic agent in a rat model of Huntington's disease, Fernández-Ruiz, J., Di Marzo, V., Ramos, J.A., Urbani, P., De Lago, E., 2005, 10.1016/j.brainres.2005.05.024

Role of the endogenous cannabinoid system in the formalin test of ersistent pain in the rat, Rice, A.S.C., Di Marzo, V., Ambrosino, G., Farquhar-Smith, W.P., Punwar, S., Bisogno, T., Beaulieu, P., 2000, 10.1016/S0014-2999(00)00226-0

New tetrazole-based selective anandamide uptake inhibitors, Di Marzo, V., Nalli, M., Morera, E., Ligresti, A., De Petrocellis, L., Cascio, M.G., Schiano Moriello, A., Ortar, G., 2008, 10.1016/j.bmcl.2008.04.003

Effect of narrowband ultraviolet B treatment on endocannabinoid plasma levels in patients with psoriasis, Di Marzo, V., Moura, D., Piscitelli, F., Serrão, M.P., Moura, E., Vieira-Coelho, M.A., Magina, S., 2014, 10.1111/bjd.12916

Biochemistry and pharmacology of endovanilloids, Di Marzo, V., Nigam, S., Starowicz, K., 2007, 10.1016/j.pharmthera.2007.01.005

Tetrahydrolipstatin analogues as modulators of endocannabinoid 2-arachidonoylglycerol metabolism, Di Marzo, V., Nalli, M., Morera, E., Ligresti, A., Bisogno, T., Ortar, G., 2008, 10.1021/jm800978m

The biosynthesis, fate and pharmacological properties of endocannabinoids., Bisogno, T., De Petrocellis, L., Di Marzo, V., Handbook of experimental pharmacology, 2005

Endocannabinoids: Synthesis and degradation, Di Marzo, V., 2008, 10.1007/112-0505

Development of an activity-based probe and in silico design reveal highly selective inhibitors for diacylglycerol lipase-α in brain, Vanderstelt, M., Overkleeft, H.S., Dimarzo, V., Brouwer, J., Vandermarel, G.A., Vandenelst, H., Meeuwenoord, N., Florea, B.I., McGuire, R., Hoogendoorn, S., Allarà, M., Dendulk, H., Vanesbroeck, A.C.M., Janssen, F.J., Baggelaar, M.P., Angewandte Chemie - International Edition, 2013, 10.1002/anie.201306295

Amygdalar CB2 cannabinoid receptor mediates fear extinction deficits promoted by orexin-A/hypocretin-1, Berrendero, F., Di Marzo, V., Maldonado, R., Hillard, C.J., Romero, J., Cristino, L., Izquierdo-Luengo, C., Piscitelli, F., Pereda-Pérez, I., Flores, Á., Ten-Blanco, M., Biomedicine and Pharmacotherapy, 2022, 10.1016/j.biopha.2022.112925

Noladin ether, a putative novel endocannabinoid: Inactivation mechanisms and a sensitive method for its quantification in rat tissues, Di Marzo, V., Mechoulam, R., Appendino, G., Minassi, A., Bisogno, T., Fezza, F., 2002, 10.1016/S0014-5793(02)02341-4

Resorcinol-sn-glycerol derivatives: Novel 2-Arachidonoylglycerol mimetics endowed with high affinity and selectivity for cannabinoid type 1 receptor, Di Marzo, V., Corelli, F., Pertwee, R.G., Brizzi, V., Biotti, I., Aiello, F., Ligresti, A., Frosini, M., Cascio, M.G., Brizzi, A., 2011, 10.1021/jm200529h

Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: A critical revisitation, Di Marzo, V., Nalli, M., Morera, E., Camalli, M., Moriello, A.S., Cascio, M.G., Ortar, G., 2008, 10.1016/j.ejmech.2007.02.023

Protective effect of palmitoylethanolamide in a rat model of cystitis, Izzo, A.A., Orlando, P., Di Marzo, V., Fiorenzani, P., Valacchi, G., Buono, L., Aveta, T., Borrelli, F., Capasso, R., Pessina, F., Journal of Urology, 2015, 10.1016/j.juro.2014.11.083

Anticipatory and consummatory effects of (hedonic) chocolate intake are associated with increased circulating levels of the orexigenic peptide ghrelin and endocannabinoids in obese adults, Sartorio, A., Di Marzo, V., Cella, S.G., Bini, S., De Col, A., Agosti, F., Aveta, T., Piscitelli, F., Rigamonti, A.E., Food and Nutrition Research, 2015, 10.3402/fnr.v59.29678

The endocannabinoid system: A general view and latest additions, Di Marzo, V., Cascio, M.G., De Petrocellis, L., 2004, 10.1038/sj.bjp.0705666

"Redundancy" of endocannabinoid inactivation: New challenges and opportunities for pain control, Di Marzo, V., Piscitelli, F., 2012, 10.1021/cn300015x

Changes in spinal and supraspinal endocannabinoid levels in neuropathic rats, Di Marzo, V., Maione, S., Rossi, F., Bisogno, T., de Novellis, V., Palazzo, E., Petrosino, S., 2007, 10.1016/j.neuropharm.2006.08.011

Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain, Sandra Gemma, Stefania Butini, Vincenzo di Marzo, Giuseppe Campiani, Patrizia Minetti, Alessia Ligresti, Marco Allarà, Carla Ghelardini, Lorenzo Di Cesare Mannelli, Giuseppe Valacchi, Alessandra Pecorelli, Mascia Benedusi, Marco Paolino, Samuele Maramai, Alessandro Grillo, Simone Brogi, Giuseppe Borrelli, Margherita Brindisi, ChemMedChem, 2018, 10.1002/cmdc.201800397

A structure-activity relationship study on N -arachidonoyl-amino acids as possible endogenous inhibitors of fatty acid amide hydrolase, Di Marzo, V., Burstein, S., Appendino, G., Ligresti, A., Minassi, A., Cascio, M.G., 2004, 10.1016/j.bbrc.2003.12.075

N-Oleoylglycine and N-Oleoylalanine Do Not Modify Tolerance to Nociception, Hyperthermia, and Suppression of Activity Produced by Morphine, Parker, L.A., Mechoulam, R., Di Marzo, V., Lichtman, A.H., DeVuono, M.V., Sullivan, M.T., Limebeer, C.L., Rock, E.M., Frontiers in Synaptic Neuroscience, 2021, 10.3389/fnsyn.2021.620145

Arvanil inhibits T lymphocyte activation and ameliorates autoimmune encephalomyelitis, Bifulco, M., Lechler, R.I., Di Marzo, V., Bisogno, T., Laezza, C., Grimaldi, C., Pisanti, S., Matarese, G., Malfitano, A.M., 2006, 10.1016/j.jneuroim.2005.09.005

Lifestyle and Metabolic Syndrome: Contribution of the Endocannabinoidome, Cristoforo Silvestri, Vincenzo Di Marzo, Nutrients, 2019, 10.3390/nu11081956

Endocannabinoids 3. Diseases of peripheral organs involving the endocannabinoid system and their possible treatment with endocannabinoid-based drugs, De Petrocellis, L., Matias, I., Di Marzo, V., 2002

Elevation of plasma 2-arachidonoylglycerol levels in alzheimer's disease patients as a potential protective mechanism against neurodegenerative decline, Di Marzo, V., Vernieri, F., Seccia, S., Palazzo, P., Quattrocchi, C., Scrascia, F., Piscitelli, F., Errante, Y., Montesano, D., Martini, M.G., Ventriglia, M., Altamura, C., Journal of Alzheimer's Disease, 2015, 10.3233/JAD-142349

A marine mollusc provides the first example of in vivo storage of prostaglandins: Prostaglandin-1,15-lactones, Villani, G., Spinella, A., Sodano, G., Di Marzo, V., Crispino, A., Cimino, G., 1991, 10.1007/BF02041252

Combined CoMFA and CoMSIA 3D-QSAR study of benzimidazole and benzothiophene derivatives with selective affinity for the CB2 cannabinoid receptor, Jaime Mella, C. David Pessoa-Mahana, Vincenzo Di Marzo, Carlos F. Lagos, Marcos Lorca, Cesar Morales-Verdejo, Mario Faúndez, Ricardo A. Tapia, Hery Chung, Javier Romero-Parra, European Journal of Pharmaceutical Sciences, 2017, 10.1016/j.ejps.2017.01.037

Piperazinyl carbamate fatty acid amide hydrolase inhibitors and transient receptor potential channel modulators as "dual-target" analgesics, Di Marzo, V., Ortar, G., Verde, R., Guida, F., Boccella, S., Comelli, F., De Chiaro, M., Morera, E., Piscitelli, F., Costa, B., Maione, S., 2013, 10.1016/j.phrs.2013.07.003

Design and Synthesis of New Transient Receptor Potential Vanilloid Type-1 (TRPV1) Channel Modulators: Identification, Molecular Modeling Analysis, and Pharmacological Characterization of the N-(4-Hydroxy-3-methoxybenzyl)-4-(thiophen-2-yl)butanamide, a Small Molecule Endowed with Agonist TRPV1 Activity and Protective Effects against Oxidative Stress, Brizzi, A., Corelli, F., Di Marzo, V., Maione, S., Alcaro, S., Valacchi, G., De Petrocellis, L., Schiano Moriello, A., Frosini, M., Costa, G., Allarà, M., Artese, A., Ligresti, A., Luongo, L., Guida, F., Aldinucci, C., Maestrini, V., Sticozzi, C., Pessina, F., Badolato, M., Aiello, F., ACS Chemical Neuroscience, 2016, 10.1021/acschemneuro.5b00333

Chemical synthesis, pharmacological characterization, and possible formation in unicellular fungi of 3-hydroxy-anandamide, Di Marzo, V., Appendino, G., Nigam, S., Hill, K., Ligresti, A., Ciccoli, R., Bisogno, T., Schaefer, M., Mainieri, F., Deva, R., De Petrocellis, L., 2009, 10.1194/jlr.M800337-JLR200

Anandamide, an endogenous cannabinomimetic eicosanoid: 'Killing two birds with one stone', Fontana, A., Di Marzo, V., 1995, 10.1016/0952-3278(95)90077-2

A novel multifunctional metabolic pathway in a marine mollusc leads to unprecedented prostaglandin derivatives (prostaglandin 1,15-lactones), Spinella, A., Sodano, G., Minardi, C., Crispino, A., Cimino, G., Di Marzo, V., 1991

CB 1 Cannabinoid Receptors Mediate Cognitive Deficits and Structural Plasticity Changes During Nicotine Withdrawal, Fernando Berrendero, Rafael Maldonado, Andrés Ozaita, Giovanni Marsicano, Vincenzo Di Marzo, Rafael de la Torre, Antoni Pastor, Arnau Busquets-Garcia, Ainhoa Plaza-Zabala, Rocio Saravia, África Flores, Biological Psychiatry, 2017, 10.1016/j.biopsych.2016.07.007

Negative regulation of leptin-induced reactive oxygen species (ROS) formation by cannabinoid CB₁ receptor activation in hypothalamic neurons, Di Marzo, V., Cristino, L., Martella, A., Piscitelli, F., Morello, G., Imperatore, R., Silvestri, C., Palomba, L., Journal of Biological Chemistry, 2015, 10.1074/jbc.M115.646885

Prostamide F_2α receptor antagonism combined with inhibition of FAAH may block the pro-inflammatory mediators formed following selective FAAH inhibition, Di Marzo, V., Woodward, D., Luongo, L., Palmieri, V., Allarà, M., Guida, F., Wang, J., Martos, J., Ligresti, A., British Journal of Pharmacology, 2014, 10.1111/bph.12410

FAAH and anandamide: is 2-AG really the odd one out?, Maccarrone, M., Di Marzo, V., 2008, 10.1016/j.tips.2008.03.001

Social defeat leads to changes in the endocannabinoid system: An overexpression of calreticulin and motor impairment in mice, Havemann-Reinecke, U., Di Marzo, V., Hoyer-Fender, S., Beißbarth, T., Lorenzen, S., Pommerenke, C., Salinas-Riester, G., Agbemenyah, H., Moore, T.P., del Río, J.A., Gil, V., Piscitelli, F., Tomas-Roig, J., Behavioural Brain Research, 2016, 10.1016/j.bbr.2016.01.036

Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors, Di Marzo, V., Woodward, D.F., Rossi, F.S., Palazzo, E., Petrosino, S., Moriello, A.S., De Novellis, V., De Petrocellis, L., Maione, S., 2007, 10.1038/sj.bjp.0707145

Cyercenes, novel pyrones from the ascoglossan mollusc Cyerce cristallina. Tissue distribution, biosynthesis and possible involvement in defense and regenerative processes, Cimino, G., Minei, R., Villani, G., De Petrocellis, L., Vardaro, R.R., Di Marzo, V., 1991

High molecular weight polyacetylenes from Petrosia ficiformis: Further structural analysis and biological activity, Di Marzo, V., De Rosa, S., De Giulio, A., Cimino, G., 1989, 10.1016/S0040-4039(00)99441-3

Cannabidiol in sport: Ergogenic or else?, Heyman, E., Di Marzo, V., Berthoin, S., Aucouturier, J., Mendes, A., Cuvelier, G., Gamelin, F.-X., Pharmacological Research, 2020, 10.1016/j.phrs.2020.104764

Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice, Di Marzo, V., Orlando, P., Capasso, F., Gallo, L., Piscitelli, F., Romano, B., Borrelli, F., Aviello, G., Capasso, R., Izzo, A.A., 2012, 10.1111/j.1476-5381.2012.01879.x

Germ-free mice exhibit profound gut microbiota-dependent alterations of intestinal endocannabinoidome signaling, Silvestri, C., Di Marzo, V., Cani, P.D., Raymond, F., Muccioli, G.G., Flamand, N., Veilleux, A., Houde, A., Martin, C., Lacroix, S., Deschênes, T., Leblanc, N., Boubertakh, B., Manca, C., Journal of Lipid Research, 2020, 10.1194/jlr.RA119000424

The Effects of Peripubertal THC Exposure in Neurodevelopmental Rat Models of Psychopathology, Vincenzo Micale, claudio d'addario, Vincenzo Di Marzo, Filippo Drago, Claudio Bucolo, Carsten T. Wotjak, Fabiana Piscitelli, Petr Palivec, Samuele Laudani, Martin Kuchar, Giovanni Luca Romano, Jana Ruda-Kucerova, Fabio Arturo Iannotti, Serena Di Martino, Tibor Stark, Martina Di Bartolomeo, International Journal of Molecular Sciences, 2023, 10.3390/ijms24043907

Activation of the endocannabinoid system as therapeutic approach in a murine model of multiple sclerosis, Guaza, C., Di Marzo, V., López-Rodríguez, M.L., Viso, A., Correa, F., Árevalo-Martín, Á., Molina-Holgado, E., Ortega-Gutiérrez, S., 2005, 10.1096/fj.04-2464fje

Exploring the endocannabinoidome in genetically obese (ob/ob) and diabetic (db/db) mice: Links with inflammation and gut microbiota, Di Marzo, V., Cani, P.D., Silvestri, C., Delzenne, N.M., Van Hul, M., Depommier, C., Flamand, N., Manca, C., Suriano, F., Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 2022, 10.1016/j.bbalip.2021.159056

Role of osteopathic manipulative treatment in altering pain biomarkers: A pilot study, DiMarzo, V., McClanahan, B., Trinh, C., Rhodes, D.C.J., Towns, L.C., Johnson, J.C., Darmani, N.A., Degenhardt, B.F., Journal of the American Osteopathic Association, 2007

Short and efficient synthesis of alkylresorcinols: a route for the preparation of cannabinoids, Vincenzo Di Marzo, Hannah Straker, Rosaria Villano, New Journal of Chemistry, 2022, 10.1039/D2NJ03547B

Changes in endocannabinoid contents in reward-related brain regions of alcohol-exposed rats, and their possible relevance to alcohol relapse, Ramos, J.A., Di Marzo, V., Fernández-Ruiz, J., Fezza, F., De Miguel, R., Valenti, M., González, S., 2004, 10.1038/sj.bjp.0705963

Cannabidiol alters mitochondrial bioenergetics via VDAC1 and triggers cell death in hormone-refractory prostate cancer, Ligresti, A., Ronca, R., Marzo, V.D., Zorzano, A., Paris, D., Motta, A., Mollica, M.P., Giacomini, A., Rezzola, S., Coltrini, D., Maccarinelli, F., Cerasuolo, M., Marolda, V., Kostrzewa, M., Mahmoud, A.M., Pharmacological Research, 2023, 10.1016/j.phrs.2023.106683

Effect of acyclic monoterpene alcohols and their derivatives on TRP channels, De Petrocellis, L., Di Marzo, V., Nalli, M., Morera, E., Schiano Moriello, A., Ortar, G., 2014, 10.1016/j.bmcl.2014.10.012

Role in anxiety behavior of the endocannabinoid system in the prefrontal cortex, Parolaro, D., Di Marzo, V., Maccarrone, M., Perletti, G., Petrosino, S., Marras, E., Viganó, D., Guidali, C., Castiglioni, C., Realini, N., Rubino, T., 2008, 10.1093/cercor/bhm161

Intense exercise increases circulating endocannabinoid and BDNF levels in humans-Possible implications for reward and depression, Meeusen, R., Di Marzo, V., Leclair, E., Roelands, B., Piscitelli, F., Goekint, M., Gamelin, F.-X., Heyman, E., 2012, 10.1016/j.psyneuen.2011.09.017

Halogenation of a capsaicin analogue leads to novel vanilloid TRPV1 receptor antagonists, Di Marzo, V., Geppetti, P., Benvenuti, F., Trevisani, M., Moriello, A.S., Bianchi, F., Daddario, N., De Petrocellis, L., Harrison, S., Appendino, G., 2003, 10.1038/sj.bjp.0705387

Desulfohaplosamate, a new phosphate-containing steroid from Dasychalina sp., is a selective cannabinoid CB₂ receptor ligand, Di Marzo, V., Ligresti, A., Dien, H.A., Calcinai, B., Bavestrello, G., Taglialatela-Scafati, O., Fattorusso, E., Chianese, G., Steroids, 2011, 10.1016/j.steroids.2011.03.013

Control of experimental spasticity by targeting the degradation of endocannabinoids using selective fatty acid amide hydrolase inhibitors, Baker, D., Giovannoni, G., Cravatt, B.F., Long, J.Z., Di Marzo, V., Bisogno, T., Fernández-Ruiz, J., Cabranes, A., Pryce, G., 2013, 10.1177/1352458513485982

Effects of repeated long-term psychosocial stress and acute cannabinoid exposure on mouse corticostriatal circuitries: Implications for neuropsychiatric disorders, Ursula Havemann-Reinecke, Vincenzo Di Marzo, Sigrid Hoyer-Fender, Tim Beißbarth, Stephan Lorenzen, Claudia Pommerenke, Gabriela Salinas, Hope Agbemenyah, Timothy Patrick Moore, Jose Antonio del Río, Lluís l. Ramió-Torrentà, Ester Quintana, Vanesa Gil, Fabiana Piscitelli, Jordi Tomas-Roig, CNS Neuroscience & Therapeutics, 2018, 10.1111/cns.12810

Antibiotic-induced microbiota perturbation causes gut endocannabinoidome changes, hippocampal neuroglial reorganization and depression in mice, S. Maione, R. Cuomo, V. Di Marzo, V. de Novellis, D. Ercolini, F. Piscitelli, F.A. Iannotti, F. De Filippis, A. Usiello, M. Mazzitelli, L. Luongo, S. Boccella, F. Napolitano, A. Furiano, G. Sarnelli, I. Palumbo, D. De Gregorio, M. Iannotta, F. Turco, F. Guida, Brain, Behavior, and Immunity, 2018, 10.1016/j.bbi.2017.09.001

The endocannabinoidome in human placenta: Possible contribution to the pathogenesis of preeclampsia, Correia-da-Silva, G., Di Marzo, V., Teixeira, N., Braga, J., Braga, A., Fonseca, B.M., Piscitelli, F., Iannotti, F.A., Maia, J., BioFactors, 2023, 10.1002/biof.1952

Abdominal obesity, metabolic syndrome, and risk of cardiovascular disease, Di Marzo, V., Despres, J.-P., Abdominal Obesity and the Endocannabinoid System: From Basic Aspects to Clinical Management of Related Cardiometabolic Risk, 2008

Placidenes: cyercene-like polypropionate γ-pyrones from the mediterranean ascoglossan mollusc Placida dendritica, Cimino, G., Di Marzo, V., Vardaro, R.R., Tetrahedron Letters, 1992, 10.1016/S0040-4039(00)78884-8

Cannabidivarin completely rescues cognitive deficits and delays neurological and motor defects in male Mecp2 mutant mice, Daniela Parolaro, Vincenzo Di Marzo, Tiziana Rubino, Charlotte Kilstrup-Nielsen, Nicoletta Landsberger, Giorgio Binelli, Marco Tramarin, Isabella Barbiero, Marie Woolley-Roberts, James S Brodie, Fabiana Piscitelli, Marina Gabaglio, Erica Zamberletti, Journal of Psychopharmacology, 2019, 10.1177/0269881119844184

Fatty acids amide hydrolase, an enzyme with many bioactive substrates. Possible therapeutic implications, Di Marzo, V., De Petrocellis, L., Bisogno, T., 2002, 10.2174/1381612023395655

Improvement in coronary circulatory function in morbidly obese individuals after gastric bypass-induced weight loss: Relation to alterations in endocannabinoids and adipocytokines, Schindler, T.H., Golay, A., Mach, F., Ratib, O., Di Marzo, V., Staub, C., Ambrosio, G., Thomas, A., Pataky, Z., Montecucco, F., Quercioli, A., 2013, 10.1093/eurheartj/eht085

Biosynthesis of hydroxyeicosatetraenoic acids (HETEs) in marine and freshwater hydroids, Cimino, G., Villani, G., Milone, A., De Petrocellis, L., Gianfrani, C., Di Marzo, V., 1993, 10.1016/0305-0491(93)90048-A

(Wh)olistic (E)ndocannabinoidome-Microbiome-Axis Modulation through (N)utrition (WHEN) to Curb Obesity and Related Disorders, Vincenzo Di Marzo, Jyoti Sihag, Lipids in Health and Disease, 2022, 10.1186/s12944-021-01609-3

Facile and Sustainable Synthesis of Commendamide and its Analogues, Di Marzo, V., Tinto, F., Villano, R., Frontiers in Chemistry, 2022, 10.3389/fchem.2022.858854

Finding of the endocannabinoid signalling system in Hydra, a very primitive organism: Possible role in the feeding response, Di Marzo, V., Milone, A., Bisogno, T., Melck, D., De Petrocellis, L., 1999, 10.1016/S0306-4522(98)00749-0

The vanilloid receptor (VR1)-mediated effects of anandamide are potently enhanced by the cAMP-dependent protein kinase, Di Marzo, V., Geppetti, P., Davis, J.B., Creminon, C., Smith, G.D., Brandi, I., Tognetto, M., Bisogno, T., Harrison, S., De Petrocellis, L., 2001, 10.1046/j.1471-4159.2001.00406.x

Δ9-tetrahydrocannabivarin impairs epithelial calcium transport through inhibition of TRPV5 and TRPV6, Thomas Voets, Vincenzo Di Marzo, Jo M. Vanoevelen, Andrea Martella, Cristoforo Silvestri, Annelies Janssens, Pharmacological Research, 2018, 10.1016/j.phrs.2018.08.021

The role of the endocannabinoid system in alzheimer's disease: Facts and hypotheses, Di Marzo, V., Bisogno, T., 2008, 10.2174/138161208785740027

Viewpoint: The endocannabinoid system, Di Marzo, V., 2006

The endocannabinoid 2-AG controls skeletal muscle cell differentiation via CB1 receptor-dependent inhibition of K_v7 channels, Di Marzo, V., Taglialatela, M., Harkany, T., Bíŕo, T., Czifra, G., Petrosino, S., Ambrosino, P., Piscitelli, F., Calvigioni, D., Martella, A., Mazzarella, E., Silvestri, C., Iannotti, F.A., Proceedings of the National Academy of Sciences of the United States of America, 2014, 10.1073/pnas.1406728111

Why endocannabinoids are not all alike, Cristino, L., Di Marzo, V., 2008, 10.1038/nn0208-124

Adolescent exposure to THC in female rats disrupts developmental changes in the prefrontal cortex, Parolaro, D., Di Marzo, V., Tonini, R., Ligresti, A., Sagheddu, C., Melis, M., Trusel, M., Zamberletti, E., Piscitelli, F., Prini, P., Rubino, T., 2015, 10.1016/j.nbd.2014.09.015

The A1 adenosine receptor as a new player in microglia physiology, Maione, S., Rossi, F., de Novellis, V., Usiello, A., Cappellacci, L., Petrelli, R., Bellini, G., Di Marzo, V., Siniscalco, D., Giordano, C., Cristino, L., Gatta, L., Napolitano, F., Imperatore, R., Guida, F., Luongo, L., 2014, 10.1002/glia.22592

Harnessing the pyrroloquinoxaline scaffold for FAAH and MAGL interaction: Definition of the structural determinants for enzyme inhibition, Gemma, S., Di Marzo, V., Campiani, G., Ligresti, A., Allarà, M., Novellino, E., Butini, S., Borrelli, G., Grillo, A., Maramai, S., Brogi, S., Brindisi, M., RSC Advances, 2016, 10.1039/c6ra12524g

The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling, Bab, I., Shohami, E., Yirmiya, R., Mechoulam, R., Zimmer, A., Karsak, M., Ledent, C., Shteyer, A., Casap, N., Regev, E., Alexandrovich, A., Leo, G., Petrosino, S., Di Marzo, V., Trembovler, V., Tam, J., 2008, 10.1096/fj.06-7957com

Formation of a covalent disulfide-linked antithrombin-albumin complex by an antithrombin variant, antithrombin 'Northwick Park', Morris, H.R., Blench, I., Di Marzo, V., Panico, M., Ireland, H., Lane, D.A., Erdjument, H., 1987

A Glucuronic Acid-Palmitoylethanolamide Conjugate (GLUPEA) Is an Innovative Drug Delivery System and a Potential Bioregulator, Stefania Petrosino, Vincenzo Di Marzo, Angelo A. Izzo, Ester Pagano, Luciano De Petrocellis, Marco Allarà, Roberta Verde, Francesco Tinto, Aniello Schiano Moriello, Emiliano Manzo, Cells, 2021, 10.3390/cells10020450

Effects of palmitoylethanolamide on the cutaneous allergic inflammatory response in Ascaris hypersensitive Beagle dogs, Puigdemont, A., Marzo, V.D., Petrosino, S., Miolo, A., della Valle, M.F., Brazis, P., Cerrato, S., Veterinary Journal, 2012, 10.1016/j.tvjl.2011.04.002

Structure-activity relationships of the ultrapotent vanilloid resiniferatoxin (RTX): The homovanillyl moiety, Marzo, V.D., Petrocellis, L.D., Bacchiega, S., Minassi, A., Ech-Chahad, A., Appendino, G., Bioorganic and Medicinal Chemistry Letters, 2007, 10.1016/j.bmcl.2006.09.077

Altered gut microbiota and endocannabinoid system tone in vitamin D deficiency-mediated chronic pain, Sabatino Maione, Vincenzo Di Marzo, Danilo Ercolini, Livio Luongo, Ida Marabese, Dario Siniscalco, Flavia Ricciardi, Salvatore Paino, Francesca De Filippis, Fabiana Piscitelli, Monica Iannotta, Carmela Belardo, Serena Boccella, Francesca Guida, Brain, Behavior, and Immunity, 2019, 10.1016/j.bbi.2019.04.006

Preclinical investigation in FAAH inhibition as a neuroprotective therapy for frontotemporal dementia using TDP-43 transgenic male mice, de Lago, E., Fernández-Ruiz, J., Di Marzo, V., Shen, C.-K.J., Lauritano, A., Piscitelli, F., Villegas, P., Rodríguez-Cueto, C., Santos-García, I., Journal of Neuroinflammation, 2023, 10.1186/s12974-023-02792-z

Orexin-A/Hypocretin-1 Controls the VTA-NAc Mesolimbic Pathway via Endocannabinoid-Mediated Disinhibition of Dopaminergic Neurons in Obese Mice, Cristino, L., Di Marzo, V., de Girolamo, P., Imperatore, R., Piscitelli, F., Forte, N., Fernández-Rilo, A.C., D'Angelo, L., Tunisi, L., Frontiers in Synaptic Neuroscience, 2021, 10.3389/fnsyn.2021.622405

Platelet activating factor-mediated leukotriene biosynthesis in rat lungs: effect of prostaglandins E₁ and F_1a, Morris, H.R., Tippins, J.R., Di Marzo, V., Biochemical and Biophysical Research Communications, 1987, 10.1016/S0006-291X(87)80199-7

Experimental ischemia/reperfusion model impairs endocannabinoid signaling and Na+/K+ ATPase expression and activity in kidney proximal tubule cells, Marcelo Einicker-Lamas, Vincenzo Di Marzo, Ricardo A.M. Reis, Fabiana Piscitelli, Fabrizia De Maio, Rosa T. Borelli-Tôrres, Luciana Veneziani, Fabio A. Iannotti, Luzia S. Sampaio, Biochemical Pharmacology, 2018, 10.1016/j.bcp.2018.06.005

Minor bio active polyacetylenes from petrosia ficiformis, Marzo, V.D., Rosa, S.D., Giulio, A.D., Cimino, G., Journal of Natural Products, 1990, 10.1021/np50068a012

Development of the first potent and specific inhibitors of endocannabinoid biosynthesis, Di Marzo, V., Razdan, R., Martin, B., Saturnino, C., Appendino, G., Minassi, A., Urbani, P., Mahadevan, A., Saha, B., Cascio, M.G., Bisogno, T., 2006, 10.1016/j.bbalip.2005.12.009

Arachidonic acid and eicosanoids as targets and effectors in second messenger interactions, Di Marzo, V., 1995, 10.1016/0952-3278(95)90123-X

Synthesis, cannabinoid receptor affinity, and molecular modeling studies of substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides, Corelli, F., Di Marzo, V., Novellino, E., Botta, M., Pasquini, S., Brizzi, A., Lavecchia, A., Piscitelli, F., La Regina, G., Cascio, M.G., Silvestri, R., 2008, 10.1021/jm070566z

Investigation of the structure/activity relationship of human calcitonin gene-related peptide (CGRP), MacIntyre, I., Morris, H.R., Panico, M., Di Marzo, V., Tippins, J.R., 1986, 10.1016/0006-291X(86)90392-X

Leucettamols, bifunctionalized marine sphingoids, act as modulators of TRPA1 and TRPM8 channels, Taglialatela-Scafati, O., Di Marzo, V., De Petrocellis, L., Schiano Moriello, A., Bavestrello, G., Calcinai, B., Putra, M.Y., Fattorusso, E., Chianese, G., 2012, 10.3390/md10112435

Occurrence and metabolism of anandamide and related acyl-ethanolamides in ovaries of the sea urchin Paracentrotus lividus, Di Marzo, V., Cimino, G., Mosca, M., Milone, A., Ventriglia, M., Bisogno, T., 1997, 10.1016/S0005-2760(97)00009-X

Endocannabinoids and the regulation of their levels in health and disease, Petrosino, S., Di Marzo, V., 2007, 10.1097/MOL.0b013e32803dbdec

Selective inhibition of anandamide cellular uptake versus enzymatic hydrolysis - A difficult issue to handle, Di Marzo, V., López-Rodríguez, M.L., Ligresti, A., Tiger, G., Fowler, C.J., 2004, 10.1016/j.ejphar.2004.03.048

Gene deletion studies reveal a critical role for prostamide/prostaglandin F2α synthase in prostamide f2α formation, Overby, D.R., Watanabe, K., Sakimura, K., Yamazaki, M., Di Marzo, V., Piscitelli, F., Silvestri, C., Spenlehauer, A., Sherwood, J.M., Woodward, D.F., Bertrand, J.A., bioRxiv, 2020, 10.1101/2020.04.01.020768

The Involvement of the Endocannabinoid System in the Peripheral Antinociceptive Action of Ketamine, Thiago R.L. Romero, Igor D.G. Duarte, Vincenzo Di Marzo, Fabiana Piscitelli, Marina G.M. Castor, Renata C.M. Ferreira, The Journal of Pain, 2018, 10.1016/j.jpain.2017.12.002

Gut feelings about the endocannabinoid system, Piscitelli, F., Di Marzo, V., 2011, 10.1111/j.1365-2982.2011.01689.x

Comparative biology of the endocannabinoid system: Possible role in the immune response, Di Marzo, V., Bisogno, T., Breton, C., Salzet, M., 2000, 10.1046/j.1432-1327.2000.01550.x

Biosynthesis and inactivation of the endocannabinoid 2- arachidonoylglycerol in circulating and tumoral macrophages, George Kunos, Wagner, J.A., Orlando, P., Melck, D., De Petrocellis, L., Bisogno, T., Di Marzo, V., 1999, 10.1046/j.1432-1327.1999.00631.x

The blockade of the transient receptor potential vanilloid type 1 and fatty acid amide hydrolase decreases symptoms and central sequelae in the medial prefrontal cortex of neuropathic rats, Maione, S., Rossi, F., Palazzo, E., Di Marzo, V., Piscitelli, F., Boccella, S., Siniscalco, D., Marabese, I., De Chiaro, M., Bellini, G., Luongo, L., Gatta, L., Vita, D., de Novellis, V., 2011, 10.1186/1744-8069-7-7

Finding of endocannabinoids in human eye tissues: Implications for glaucoma, Di Marzo, V., Woodward, D.F., Nieves, A., Venezia, S., Lu, T., Dinh, T., Matias, I., Chen, J., 2005, 10.1016/j.bbrc.2005.03.095

Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment, Angela Rampa, Alessia Ligresti, Andrea Tarozzi, Alessandra Bisi, Vincenzo Di Marzo, Silvia Gobbi, Federica Belluti, Isabel Iriepa, Barbara Monti, Manuela Bartolini, Ignacio Moraleda, Sabrina Petralla, Marina Naldi, Alessandro Rabbito, Letizia Pruccoli, Ali Mokhtar Mahmoud, Serena Montanari, European Journal of Medicinal Chemistry, 2019, 10.1016/j.ejmech.2019.05.080

Involvement of the cannabimimetic compound, N-palmitoyl-ethanolamine, in inflammatory and neuropathic conditions: Review of the available pre-clinical data, and first human studies, Di Marzo, V., Sorrentini, I., Capasso, R., Scaglione, G., Valenti, M., Degenhardt, B., Izzo, A.A., Darmani, N.A., 2005, 10.1016/j.neuropharm.2005.01.001

Discovery of non-electrophilic capsaicinoid-type TRPA1 ligands, De Petrocellis, L., Di Marzo, V., Schiano-Moriello, A., Minassi, A., Appendino, G., Caprioglio, D., Del Prete, D., Bioorganic and Medicinal Chemistry Letters, 2015, 10.1016/j.bmcl.2015.01.039

Actions of two naturally occurring saturated N-acyldopamines on transient receptor potential vanilloid 1 (TRPV1) channels, Di Marzo, V., Walker, J.M., Kellner, J.C., Schiano Moriello, A., Chu, C.J., De Petrocellis, L., 2004, 10.1038/sj.bjp.0705924

Manipulation of dietary amino acids prevents and reverses obesity in mice through multiple mechanisms that modulate energy homeostasis, Nisoli, E., Valerio, A., Collins, S., Coppari, R., Condorelli, G., Decimo, I., Cinti, S., Carruba, M.O., Luchinat, C., Di Marzo, V., Bifari, F., Tuohy, K., Scholz, M., Rizzetto, L., Tenori, L., Ceddia, R.P., Ponzoni, L., Liu, D., Severi, I., Pino, A., Greco, C.M., Tedesco, L., Bontems, F., Ioris, R.M., Manzo, E., Cutignano, A., Piscitelli, F., Ghini, V., Carullo, P., Rossi, F., Ragni, M., Ruocco, C., Diabetes, 2020, 10.2337/db20-0489

A histological and chemical study of the cerata of the opisthobranch mollusc Tethys fimbria, Cimino, G., Di Marzo, V., Marin, A., 1991, 10.1007/BF01319406

Intestinal epithelial N-acylphosphatidylethanolamine phospholipase D links dietary fat to metabolic adaptations in obesity and steatosis, Patrice D. Cani, Vincenzo Di Marzo, Nicolas Flamand, Serge Luquet, Willem M. de Vos, Giulio G. Muccioli, Nathalie M. Delzenne, Sylvie Robine, Céline Druart, Lucie Geurts, Alice de Wouters d’Oplinter, Matthias Van Hul, Marialetizia Rastelli, Hubert Plovier, Amandine Everard, Nature Communications, 2019, 10.1038/s41467-018-08051-7

β-Casomorphins: Substitution of phenylalanine with β-homo phenylalanine increases the μ-type opioid receptor affinity, Cammarota, G., Marzo, V.D., Santini, A., Siciliano, R., Melck, D., Longobardo, L., Bioorganic and Medicinal Chemistry Letters, 2000, 10.1016/S0960-894X(00)00187-6

The endocannabinoid system as a target for the development of new drugs for cancer therapy,Il sistema endocannabinoide quale bersaglio di terapie anti-tumorali. Conoscenze attuali e prospettive, Di Marzo, V., Bifulco, M., Recenti Progressi in Medicina, 2003

Desensitization of transient receptor potential vanilloid type-1 (TRPV1) channel as promising therapy of irritable bowel syndrome: characterization of the action of palvanil in the mouse gastrointestinal tract, Zielińska, M., Fichna, J., Storr, M., Di Marzo, V., Wasilewski, A., Włodarczyk, J., Szymaszkiewicz, A., Naunyn-Schmiedeberg's Archives of Pharmacology, 2020, 10.1007/s00210-020-01829-x

The endocannabinoid system and the molecular basis of paralytic ileus in mice., Di Marzo, V., Capasso, F., Cecio, A., Maffia, P., Cascio, M.G., Pinto, L., Costagliola, A., Ligresti, A., Izzo, A.A., Mascolo, N., 2002

Coronary vasomotor control in obesity and morbid obesity: Contrasting flow responses with endocannabinoids, leptin, and inflammation, Schindler, T.H., Harsch, E., MacH, F., Golay, A., Ratib, O., Ambrosio, G., Vincenti, G., Di Marzo, V., Staub, C., Thomas, A., Carballo, S., Montecucco, F., Pataky, Z., Quercioli, A., 2012, 10.1016/j.jcmg.2012.01.020

N-arachidonoyl-dopamine tunes synaptic transmission onto dopaminergic neurons by activating both cannabinoid and vanilloid receptors, Mercuri, N.B., Maccarrone, M., Molinari, M., Bernardi, G., Van Der Stelt, M., Viscomi, M.T., Fezza, F., Florenzano, F., Di Marzo, V., Marinelli, S., 2007, 10.1038/sj.npp.1301118

Aquatic invertebrates open up new perspectives in eicosanoid research: Biosynthesis and bioactivity, Di Marzo, V., De Petrocellis, L., 1994, 10.1016/0952-3278(94)90183-X

The endocannabinoid system: Can it contribute to cannabis therapeutics?, Di Marzo, V., The Handbook of Cannabis Therapeutics: From Bench to Bedside, 2014, 10.1300/5741_11

Identification and characterization of cannabidiol as an ox1r antagonist by computational and in vitro functional validation, Di Marzo, V., Gray, R., Amodeo, P., De Petrocellis, L., Cristino, L., Savopoulos, R., Piscitelli, F., Tunisi, L., Moriello, A.S., Iannotti, F.A., Vitale, R.M., Biomolecules, 2021, 10.3390/biom11081134

Methionine-enkephalin presursor in neuroblastoma X glioma hybrid cells: In vivo and in vitro evidence, Palmisano, A., Marino, G., Di Marzo, V., 1984

Symptom-related changes of endocannabinoid and palmitoylethanolamide levels in brain areas of R6/2 mice, a transgenic model of Huntington's disease, Di Marzo, V., Popoli, P., Petrosino, S., Martire, A., Bisogno, T., 2008, 10.1016/j.neuint.2007.06.031

Pharmacology and physiology of the endogenous cannabimimetic mediator anandamide, Maurelli, S., Bisogno, T., De Petrocellis, L., Di Marzo, V., 1995

2-Pentadecyl-2-Oxazoline, the Oxazoline of Pea, Modulates Carrageenan-Induced Acute Inflammation, Salvatore Cuzzocrea, Vincenzo Di Marzo, Emanuela Esposito, Marika Cordaro, Rosalba Siracusa, Ramona D’Amico, Enrico Gugliandolo, Marco Allarà, Irene Paterniti, Daniela Impellizzeri, Michela Campolo, Stefania Petrosino, Frontiers in Pharmacology, 2017, 10.3389/fphar.2017.00308

Endocrine disruptors in the diet of male Sparus aurata: Modulation of the endocannabinoid system at the hepatic and central level by Di-isononyl phthalate and Bisphenol A, Oliana Carnevali, Jaume Pérez-Sánchez, Vincenzo Di Marzo, Fabiana Piscitelli, Marco Allarà, Giorgia Gioacchini, Francesca Maradonna, Josep Calduch-Giner, Constantinos C. Mylonas, Isabel Forner-Piquer, Environment International, 2018, 10.1016/j.envint.2018.06.011

The endogenous cannabinoid system controls extinction of aversive memories, Di Marzo, V., Lutz, B., Zieglgänsberger, W., Hofmann, C., Tang, J., Hermann, H., Cascioll, M.G., Rammes, G., Bisogno, T., Azad, S.C., Wotjak, C.T., Marsicano, G., 2002, 10.1038/nature00839

V-K-ras leads to preferential farneaylation of p21ras in FRTL-5 cells: Multiple interference with the isoprenoid pathway, Di Marzo, V., Laezza, C., Bifulco, M., 1998

Cannabinoid CB1 receptor mediates fear extinction via habituation-like processes, Wotjak, C.T., Lutz, B., Di Marzo, V., Bisogno, T., Tang, J., Monory, K., Marsicano, G., Kamprath, K., 2006, 10.1523/JNEUROSCI.0153-06.2006

The levels of the endocannabinoid receptor CB₂ and its ligand 2-arachidonoylglycerol are elevated in endometrial carcinoma, Iuvone, T., Di Marzo, V., Sardo, A.D.S., Nappi, C., Insabato, L., Simonetti, S., Orlando, P., Bifulco, G., Cipriano, M., Petrosino, S., D'Amico, A., De Filippis, D., Ligresti, A., Guida, M., Endocrinology, 2010, 10.1210/en.2009-0883

Characterization of endocannabinoids and related acylethanolamides in the synovial fluid of dogs with osteoarthritis: a pilot study, Antonio Di Bello, Vincenzo Di Marzo, Roberta Verde, Fabiana Piscitelli, Mariarosaria Marinaro, Delia Franchini, Debora Campanile, Carmela Valastro, BMC Veterinary Research, 2017, 10.1186/s12917-017-1245-7

Randomised clinical trial: the analgesic properties of dietary supplementation with palmitoylethanolamide and polydatin in irritable bowel syndrome, G. Barbara, V. Di Marzo, S. Petrosino, T. Iuvone, D. DeFilippis, M. Neunlist, S. Bruley des Varannes, F. Azpiroz, B. Lobo, C. Alonso Cotoner, M. Pigrau, M. Vicario, J. Santos, L. Bellacosa, M. R. Barbaro, R. F. Cogliandro, V. Stanghellini, C. Cremon, Alimentary Pharmacology & Therapeutics, 2017, 10.1111/apt.13958

N-acylvanillamides: Development of an expeditious synthesis and discovery of new acyl templates for powerful activation of the vanilloid receptor, Di Marzo, V., De Petrocellis, L., Morello, A.S., Minassi, A., Appendino, G., 2002, 10.1021/jm020844o

The endocannabinoid system: Can it contribute to cannabis therapeutics?, Di Marzo, V., Journal of Cannabis Therapeutics, 2001, 10.1300/J175v01n01_04

Expression and Functions of the CB₂ Receptor in Human Leukocytes, Flamand, N., Di Marzo, V., Simard, M., Rakotoarivelo, V., Frontiers in Pharmacology, 2022, 10.3389/fphar.2022.826400

Enantioselective synthesis and vanilloid activity evaluation of 1-β-(p-methoxycinnamoyl)polygodial, an antinociceptive compound from Drymis winteri barks, Spinella, A., Izzo, I., Landi, R., Di Marzo, V., Della Monica, C., De Petrocellis, L., 2007, 10.1016/j.bmcl.2007.10.001

Endocannabinoids and neuropathic pain: Focus on neuron-glia and endocannabinoid-neurotrophin interactions, Di Marzo, V., Maione, S., Luongo, L., 2014, 10.1111/ejn.12440

Hydra vulgaris ω10-lipoxygenase is used in vivo to synthesize new α-linolenic acid metabolites, Cimino, G., De Petrocellis, L., Di Marzo, V., Gianfrani, C., Experientia, 1995, 10.1007/BF01964919

Discovery of prostamide F _2α and its role in inflammatory pain and dorsal horn nociceptive neuron hyperexcitability, Di Marzo, V., Maione, S., Lichtman, A., Boccella, S., Giordano, C., Piscitelli, F., Gatta, L., PLoS ONE, 2012, 10.1371/journal.pone.0031111

From endocannabinoid profiling to 'endocannabinoid therapeutics', Di Marzo, V., Petrosino, S., Ligresti, A., 2009, 10.1016/j.cbpa.2009.04.615

Brain TRPV1: a depressing TR(i)P down memory lane?, Szallasi, A., Gobbi, G., Di Marzo, V., 2008, 10.1016/j.tips.2008.09.004

Neuropeptides and leukotriene release: Effect of peptide histidine isoleucine and secretin in platelet activating factor-stimulated rat lung, Morris, H.R., Tippins, J.R., Di Marzo, V., 1987, 10.1016/0143-4179(87)90032-1

Semiplenamides A-G, Fatty Acid Amides from a Papua New Guinea Collection of the Marine Cyanobacterium Lyngbya semiplena, Gerwick, W.H., Di Marzo, V., Ligresti, A., McPhail, K.L., Han, B., 2003, 10.1021/np030242n

Synthesis and pharmacological activity of a potent inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol, Di Marzo, V., Wiley, J.L., Razdan, R.K., Mahadevan, A., Saha, B., Allarà, M., Rai, R., Burston, J.J., Bisogno, T., 2009, 10.1002/cmdc.200800442

N-palmitoyl-vanillamide (palvanil) is a non-pungent analogue of capsaicin with stronger desensitizing capability against the TRPV1 receptor and anti-hyperalgesic activity, Di Marzo, V., Maione, S., De Novellis, V., Piscitelli, F., De Chiaro, M., Moriello, A.S., Guida, F., De Petrocellis, L., 2011, 10.1016/j.phrs.2010.12.019

An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity, Mechoulam, R., Di Marzo, V., De Petrocellis, L., Bisogno, T., Vogel, Z., Rhee, M.-H., Tamiri, T., Sheskin, T., Fride, E., Ben-Shabat, S., 1998, 10.1016/S0014-2999(98)00392-6

Effects of chronic exercise on the endocannabinoid system in Wistar rats with high-fat diet-induced obesity, Heyman, E., Di Marzo, V., Bastide, B., Montel, V., Cieniewski-Bernard, C., Dupont, E., Leriche, M., Aveta, T., Mazzarella, E., Piscitelli, F., Iannotti, F.A., Aucouturier, J., Gamelin, F.-X., Journal of Physiology and Biochemistry, 2016, 10.1007/s13105-016-0469-5

TRPV1 receptors in the central nervous system: Potential for previously unforseen therapeutic applications, Di Marzo, V., Cristino, L., Starowicz, K., 2008, 10.2174/138161208783330790

Important role of endocannabinoid signaling in the development of functional vision and locomotion in zebrafish, Di Marzo, V., Sordino, P., Neuhauss, S.C.F., De Girolamo, P., Carnevali, O., Fasano, G., Zang, J., Silvestri, C., Sepe, R.M., Martella, A., FASEB Journal, 2016, 10.1096/fj.201600602R

Synthesis, cannabinoid receptor affinity, molecular modeling studies and in vivo pharmacological evaluation of new substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides. 2. Effect of the 3-carboxamide substituent on the affinity and selectivity profile, Corelli, F., Marzo, V.D., Colombo, G., Novellino, E., Carai, M.A.M., Fantini, N., Allarà, M., Lavecchia, A., Pasquini, S., Brizzi, A., Gatti, V., Piscitelli, F., Regina, G.L., Ligresti, A., Silvestri, R., Bioorganic and Medicinal Chemistry, 2009, 10.1016/j.bmc.2009.06.027

Structure-affinity relationships and pharmacological characterization of new alkyl-resorcinol cannabinoid receptor ligands: Identification of a dual cannabinoid receptor/TRPA1 channel agonist, Di Marzo, V., Pertwee, R.G., Maione, S., Lamponi, S., Luongo, L., Ligresti, A., De Petrocellis, L., Brizzi, V., Corelli, F., Cascio, M.G., Marini, P., Aiello, F., Brizzi, A., 2014, 10.1016/j.bmc.2014.07.006

Ultra-micronized palmitoylethanolamide rescues the cognitive decline-associated loss of neural plasticity in the neuropathic mouse entorhinal cortex-dentate gyrus pathway, Livio Luongo, Sabatino Maione, Antonio Calignano, Vincenzo Di Marzo, Luigia Cristino, Vito de Novellis, Lea Tunisi, Roberta Imperatore, Mariacristina Mazzitelli, Enza Palazzo, Fabiana Piscitelli, Francesca Guida, Antonio Farina, Carmela Belardo, Monica Iannotta, Rosaria Romano, Claudia Cristiano, Serena Boccella, Neurobiology of Disease, 2019, 10.1016/j.nbd.2018.09.023

A brief history of cannabinoid and endocannabinoid pharmacology as inspired by the work of British scientists, Di Marzo, V., 2006, 10.1016/j.tips.2006.01.010

Cyercenes, novel polypropionate pyrones from the autotomizing mediterranean mollusc cyerce cristallina, Cimino, G., Crispino, A., Di Marzo, V., Vardaro, R.R., 1991, 10.1016/S0040-4020(01)80988-1

(-)-Menthylamine derivatives as potent and selective antagonists of transient receptor potential melastatin type-8 (TRPM8) channels, Marzo, V.D., Nalli, M., Morera, E., Orlando, P., Moriello, A.S., Morera, L., Petrocellis, L.D., Ortar, G., Bioorganic and Medicinal Chemistry Letters, 2010, 10.1016/j.bmcl.2010.03.076

Altered responses of dopamine D3 receptor null mice to excitotoxic or anxiogenic stimuli: Possible involvement of the endocannabinoid and endovanilloid systems, Di Marzo, V., Drago, F., Leggio, G.M., Petrosino, S., Tamburella, A., Cristino, L., Micale, V., 2009, 10.1016/j.nbd.2009.06.015

Unsaturated long-chain N-acyl-vanillyl-amides (N-AVAMs): Vanilloid receptor ligands that inhibit anandamide-facilitated transport and bind to CB1 cannabinoid receptors, Di Marzo, V., Bifulco, M., Julius, D., Chuang, H.-H., De Petrocellis, L., Bisogno, T., Melck, D., 1999, 10.1006/bbrc.1999.1105

Cannabinoid CB1 receptor expression in relation to visceral adipose depots, endocannabinoid levels, microvascular damage, and the presence of the Cnr1 A3813G variant in humans, Sarzani, R., Di Marzo, V., Rappelli, A., Dessì-Fulgheri, P., Petrosino, S., Piscitelli, F., Montironi, R., Mazzucchelli, R., Muzzonigro, G., Minardi, D., Refi, G., Giannini, E., Mancinelli, L., Battistoni, I., Bordicchia, M., 2010, 10.1016/j.metabol.2009.09.018

Palmitoylethanolamide reduces pain-related behaviors and restores glutamatergic synapses homeostasis in the medial prefrontal cortex of neuropathic mice, Maione, S., De Novellis, V., Di Marzo, V., Usiello, A., De Bartolomeis, A., Lattanzi, R., Piscitelli, F., Rossi, F., De Gregorio, D., D'Aniello, A., Marabese, I., Belardo, C., Napolitano, F., Iannotta, M., Romano, R., Marmo, F., Luongo, L., Guida, F., Molecular Brain, 2015, 10.1186/s13041-015-0139-5

Endocannabinoid overactivity and intestinal inflammation, Izzo, A.A., Di Marzo, V., 2006, 10.1136/gut.2005.090472

Neuronal and glial alterations in the cerebellar cortex of maternally deprived rats: Gender differences and modulatory effects of two inhibitors of endocannabinoid inactivation, Viveros, M.P., Di Marzo, V., Prada, C., Marco, E.M., Llorente-Berzal, A., Llorente, R., López-Gallardo, M., 2008, 10.1002/dneu.20672

The dual fatty acid amide hydrolase/TRPV1 blocker, N-arachidonoyl-serotonin, relieves carrageenan-induced inflammation and hyperalgesia in mice, Di Marzo, V., Giagnoni, G., Comelli, F., Petrosino, S., Bettoni, I., Costa, B., 2010, 10.1016/j.phrs.2010.02.001

Endocannabinoid signaling in the brain: Biosynthetic mechanisms in the limelight, Di Marzo, V., 2011, 10.1038/nn.2720

Biosynthesis and inactivation of endocannabinoids: Relevance to their proposed role as neuromodulators, Di Marzo, V., 1999, 10.1016/S0024-3205(99)00287-8

Lipidomic methodologies applicable to the study of endocannabinoids and related compounds: Endocannabinoidomics, Di Marzo, V., Piscitelli, F., Bisogno, T., 2009, 10.1002/ejlt.200800233

Sesquiterpenoids from common ragweed (Ambrosia artemisiifolia L.), an invasive biological polluter, Appendino, G., Di Marzo, V., De Petrocellis, L., Chianese, G., Minassi, A., Pollastro, F., Taglialatela-Scafati, O., 2012, 10.1002/ejoc.201200650

The effect of a cAMP analogue on Ca²⁺ ionophore-, antigen- and agonist-induced inositol phosphate release in rat basophilic leukemia (RBL-1) cells, Di Marzo, V., Morris, H.R., Galadari, S.H.J., BBA - Molecular Cell Research, 1992, 10.1016/0167-4889(92)90072-J

Mechanisms of HIV-1 inhibition by the lipid mediator N-arachidonoyldopamine, Muñoz, E., Di Marzo, V., Appendino, G., Macho, A., De La Vega, L., Sancho, R., 2005

Analysis of endocannabinoid signaling elements and related proteins in lymphocytes of patients with Dravet syndrome, Fernández-Ruiz, J., Sagredo, O., Di Marzo, V., Aras, L.M., Montolio, M., Barroso, E., Satta, V., Verde, R., Piscitelli, F., Valdeolivas, S., Rubio, M., Pharmacology Research and Perspectives, 2016, 10.1002/prp2.220

The uptake by cells of 2-arachidonoylglycerol, an endogenous agonist of cannabinoid receptors, Marzo, V.D., Hillard, C., Finazzi-Agrò, A., Jarrahian, A., De Petrocellis, L., Maccarrone, M., Bisogno, T., European Journal of Biochemistry, 2001, 10.1046/j.1432-1327.2001.02072.x

Cannabinoids and endocannabinoids in metabolic disorders with focus on diabetes, Mechoulam, R., Piscitelli, F., Di Marzo, V., Handbook of Experimental Pharmacology, 2015, 10.1007/978-3-642-17214-4_4

A Lipidomics- and Transcriptomics-Based Analysis of the Intestine of Genetically Obese (ob/ob) and Diabetic (db/db) Mice: Links with Inflammation and Gut Microbiota, Vincenzo Di Marzo, Patrice D. Cani, Cristoforo Silvestri, Nathalie M. Delzenne, Matthias Van Hul, Nicolas Flamand, Claudia Manca, Francesco Suriano, Cells, 2023, 10.3390/cells12030411

Adelmidrol increases the endogenous concentrations of palmitoylethanolamide in canine keratinocytes and down-regulates an inflammatory reaction in an in vitro model of contact allergic dermatitis, Di Marzo, V., Orlando, P., Aveta, T., Allarà, M., Verde, R., Fusco, M., della Valle, M.F., Puigdemont, A., Petrosino, S., Veterinary Journal, 2016, 10.1016/j.tvjl.2015.10.060

TRPV1-dependent and-independent alterations in the limbic cortex of neuropathic mice: Impact on glial caspases and pain perception, Maione, S., Di Marzo, V., De Novellis, V., Palazzo, E., Imperatore, R., Rossi, F., Gatta, L., Marabese, I., Piscitelli, F., Petrosino, S., Siniscalco, D., Luongo, L., Cristino, L., Giordano, C., 2012, 10.1093/cercor/bhr328

Attenuation of allergic contact dermatitis through the endocannabinoid system, Zimmer, A., Tüting, T., Di Marzo, V., Werner, S., Buettner, R., Mechoulam, R., Cravatt, B., Schlicker, E., Steuder, R., Starowicz, K., Petrosino, S., Rehnelt, J., Wang-Eckhardt, L., Date, R., Gaffal, E., Karsak, M., 2007, 10.1126/science.1142265

Glutamate spillover drives endocannabinoid production and inhibits GABAergic transmission in the Substantia Nigra pars compacta, Mercuri, N.B., Lipski, J., Di Marzo, V., Piscitelli, F., Guatteo, E., Freestone, P.S., 2014, 10.1016/j.neuropharm.2013.12.007

Development of the first ultra-potent "capsaicinoid" agonist at transient receptor potential vanilloid type 1 (TRPV1) channels and its therapeutic potential, Di Marzo, V., Geppetti, P., Pinna, C., Fontana, G., Campi, B., Ligresti, A., Gazzieri, D., Moriello, A.S., Daddario, N., Minassi, A., Trevisani, M., De Petrocellis, L., Appendino, G., 2005, 10.1124/jpet.104.074864

Cannabinoid CB₁-receptor mediated regulation of gastrointestinal motility in mice in a model of intestinal inflammation, Capasso, F., Di Marzo, V., Mascolo, N., Esposito, G., Iuvone, T., Pinto, L., Bisogno, T., Capasso, R., Fezza, F., Izzo, A.A., British Journal of Pharmacology, 2001, 10.1038/sj.bjp.0704293

Design, synthesis, and pharmacological characterization of indol-3-ylacetamides, indol-3-yloxoacetamides, and indol-3-ylcarboxamides: Potent and selective CB2 cannabinoid receptor inverse agonists, Corelli, F., Di Marzo, V., Maione, S., Borea, P.A., Varani, K., Luongo, L., Guida, F., Pesco, N., Pedani, V., Falciani, C., Brogi, S., Tafi, A., Ligresti, A., Mugnaini, C., Pasquini, S., 2012, 10.1021/jm3003334

Rapid and concomitant gut microbiota and endocannabinoidome response to diet-induced obesity in mice, Veilleuxa, A., Marzo, V.D., Raymond, F., Silvestri, C., Flamand, N., Martin, C., Houde, A., Boubertakh, B., Leblanc, N., Pechereau, F., Lacroix, S., mSystems, 2019, 10.1128/mSystems.00407-19

The EC system and central control of energy balance-the hypothalamus, Di Marzo, V., Abdominal Obesity and the Endocannabinoid System: From Basic Aspects to Clinical Management of Related Cardiometabolic Risk, 2008

Obesity: The Fat Tissue Disease Version of Cancer, Vincenzo Di Marzo, Cristoforo Silvestri, Besma Boubertakh, Cells, 2022, 10.3390/cells11121872

Participation of Prostaglandin E₂ in Dopamine D₂ Receptor‐Dependent Potentiation of Arachidonic Acid Release, Piomelli, D., Di Marzo, V., Journal of Neurochemistry, 1992, 10.1111/j.1471-4159.1992.tb08915.x

Altered endocannabinoidome bioactive lipid levels accompany reduced DNBS-induced colonic inflammation in germ-free mice, Di Marzo, V., Silvestri, C., Borrelli, F., Flamand, N., Leblanc, N., Giorgini, G., Venneri, T., Lipids in Health and Disease, 2023, 10.1186/s12944-023-01823-1

Endocannabinoids link feeding state and auditory perception-related gene expression, Di Marzo, V.D., Valenti, M., Tian, Q., Soderstrom, K., 2004, 10.1523/JNEUROSCI.3298-04.2004

The endocannabinoid system in renal cells: Regulation of Na ⁺ transport by CB₁ receptors through distinct cell signalling pathways, Einicker-Lamas, M., Reis, R.A.M., Vieyra, A., Di Marzo, V., Mazzarella, E., Iannotti, F.A., Sampaio, C.L.C., Lima, D., Taveira Da Silva, R., Sampaio, L.S., British Journal of Pharmacology, 2015, 10.1111/bph.13050

Dysfunctional endocannabinoid CB1 receptor expression and signaling contribute to skeletal muscle cell toxicity induced by simvastatin, Fabio Arturo Iannotti, Vincenzo Di Marzo, Raffaele Capasso, Mónika Sztretye, Fabiana Piscitelli, Claudia Moriello, Giuseppe Ercolano, Ester Pagano, Elisabetta Panza, Hilal Kalkan, Cell Death & Disease, 2023, 10.1038/s41419-023-06080-9

Functional interaction between TRPV1 and μ-opioid receptors in the descending antinociceptive pathway activates glutamate transmission and induces analgesia, Di Marzo, V., De Novellis, V., Marabese, I., Rossi, F., Luongo, L., Palazzo, E., Guida, F., Cristino, L., Starowicz, K., Maione, S., 2009, 10.1152/jn.91225.2008

Dual effect of cannabinoid CB₁ receptor stimulation on a vanilloid VR1 receptor-mediated response, Di Marzo, V., Lutz, B., Moriello, A.S., Bisogno, T., De Petrocellis, L., Hermann, H., Cellular and Molecular Life Sciences, 2003, 10.1007/s000180300052

Non-psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action, Di Marzo, V., De Novellis, V., Palazzo, E., De Petrocellis, L., Vita, D., Gatta, L., Piscitelli, F., Maione, S., 2011, 10.1111/j.1476-5381.2010.01063.x

Phospholipase A₂ and protein kinase C enzymatic activities and their interactions in Hydra vulgaris, Di Marzo, V., De Petrocellis, L., Leitz, T., Schneider, T., Capasso, A., Carginale, V., Borrelli, L., Comparative Biochemistry and Physiology -- Part B: Biochemistry and, 1995, 10.1016/0305-0491(94)00243-N

Endocannabinoids and energy homeostasis: An update, Di Marzo, V., Becker, T., Cristino, L., 2014, 10.1002/biof.1168

Palvanil, a non-pungent capsaicin analogue, inhibits inflammatory and neuropathic pain with little effects on bronchopulmonary function and body temperature, Di Marzo, V., Maione, S., De Novellis, V., De Petrocellis, L., Sullo, N., Matteis, M., Gatta, L., Comelli, F., Guida, F., D'Agostino, B., Costa, B., Luongo, L., 2012, 10.1016/j.phrs.2012.05.005

'Endocannabinoids' and other fatty acid derivatives with cannabimimetic properties: Biochemistry and possible physiopathological relevance, Di Marzo, V., 1998, 10.1016/S0005-2760(98)00042-3

Neuropeptides and inflammatory mediators: bidirectional regulatory mechanisms, Morris, H.R., Tippins, J.R., Di Marzo, V., 1989, 10.1016/0165-6147(89)90198-3

Lipopolysaccharide-induced pulmonary inflammation is not accompanied by a release of anandamide into the lavage fluid or a down-regulation of the activity of fatty acid amide hydrolase, J. Fowler, C., Di Marzo, V., Valenti, M., Hansen, H.S., Petersen, G., Bucht, A., Rocksén, D., Holt, S., 2004, 10.1016/j.lfs.2004.09.005

A novel amino acid substitution in the reactive site of a congenital variant antithrombin. Antithrombin Pescara, Arg³⁹³ to Pro, caused by CGT to CCT mutation, Thein, S.L., De Stefano, V., Leone, G., Morris, H.R., Di Marzo, V., Panico, M., Thompson, E., Erdjument, H., Lane, D.A., Journal of Biological Chemistry, 1989

Evidence for a new G protein-coupled cannabinoid receptor in mouse brain, Martin, B.R., Di Marzo, V., Griffin, G., Breivogel, C.S., 2001

Chronic blockade of CB₁ receptors reverses startle gating deficits and associated neurochemical alterations in rats reared in isolation, Parolaro, D., Di Marzo, V., Fadda, P., Fratta, W., Rubino, T., Cadeddu, F., Piscitelli, F., Zamberletti, E., British Journal of Pharmacology, 2012, 10.1111/j.1476-5381.2012.02095.x

Leukotriene release by human fetal membranes, placenta and decidua in relation to parturition, Turnbull, A.C., Morris, H.R., Tippins, J.R., Bernal, A.L., Di Marzo, V., Rees, M.C.P., 1988

Arachidonoylethyleneglycol and its Nitroester as New Cannabimimetics: Oxidation by 15-Lipoxygenase and Hydrolysis by Fatty Acid Amide Hydrolase, Manevich, Y., Di Marzo, V., Bisogno, T., De Petrocellis, L., Marvanov, D.M., Titova, O.Yu., Kogteva, G.S., Verevochkina, E.Yu., Fedenyuk, A.P., Serkov, I.V., Archakov, A.V., Gretskaya, N.M., Bobrov, M.Yu., Bezuglov, V.V., 1998

The possible involvement of protein kinase C and phospholipase A₂ in Hydra tentacle regeneration, Cimino, G., Di Marzo, V., De Petrocellis, L., Experientia, 1993, 10.1007/BF01928791

TRPV1 channels control synaptic plasticity in the developing superior colliculus, Di Marzo, V., Salt, T.E., Starowicz, K., Georgiou, A.L., Migliozzi, A.L., Cristino, L., Maione, S., 2009, 10.1113/jphysiol.2009.171900

The endovanilloid/endocannabinoid system: A new potential target for osteoporosis therapy, Maione, S., Di Marzo, V., Nobili, B., Perrotta, S., Colacurci, N., Scafuro, M., Orlando, P., Siniscalco, D., Petrosino, S., De Petrocellis, L., Mancusi, S., Torella, M., Luongo, L., Bellini, G., Rossi, F., 2011, 10.1016/j.bone.2011.01.001

Cannabinoids and the expanded endocannabinoid system in neurological disorders, Vincenzo Di Marzo, Tiziana Bisogno, Luigia Cristino, Nature Reviews Neurology, 2020, 10.1038/s41582-019-0284-z

Effect of dietary krill oil supplementation on the endocannabinoidome of metabolically relevant tissues from high-fat-fed mice, Di Marzo, V., Banni, S., Griinari, M., Cohn, J., Tandy, S., Berge, K., Cordeddu, L., Murru, E., Bisogno, T., Carta, G., Piscitelli, F., 2011, 10.1186/1743-7075-8-51

Enzymological and molecular biological studies on anandamide amidohydrolase, De Petrocellis, L., Di Marzo, V., Katoh, I., Yamamoto, S., Suzuki, H., Suzuki, M., Kurahashi, Y., Katayama, K., Ueda, N., Advances in Experimental Medicine and Biology, 2000

The synthesis of N-vanillyl-arachidonoyl-amide (arvanil) and its analogs: An improved procedure for the synthesis of the key synthon methyl 14-hydroxy-(all-cis)-5,8,11-tetradecatrienoate, Razdan, R.K., Marzo, V.D., Martin, B.R., Han, L., Mahadevan, A., Dasse, O., Tetrahedron, 2000, 10.1016/S0040-4020(00)00877-2

In vitro and in vivo pharmacology of synthetic olivetol- or resorcinol-derived cannabinoid receptor ligands, Di Marzo, V., Maione, S., Pertwee, R., Brizzi, V., Van De Doelen, T., Ross, R., Marabese, I., De Novellis, V., Brizzi, A., Van Der Stelt, M., Thomas, A., Palazzo, E., Bisogno, T., Cascio, M.G., 2006, 10.1038/sj.bjp.0706888

Endocannabinoid signalling and the deteriorating brain, Zimmer, A., Stella, N., Di Marzo, V., Nature Reviews Neuroscience, 2015, 10.1038/nrn3876

The biosynthesis, fate and pharmacological properties of endocannabinoids, De Petrocellis, L., Bisogno, T., Di Marzo, V., Handbook of Experimental Pharmacology, 2005, 10.1007/3-540-26573-2_5

Endocannabinoids control spasticity in a multiple sclerosis model., Di Marzo, V., Bisogno, T., Fezza, F., Layward, L., Khanolkar, A., Makriyannis, A., Pertwee, R.G., Brown, P., Croxford, J.L., Pryce, G., Baker, D., 2001

Biosynthesis and metabolism of endocannabinoids and their congeners from the monoacylglycerol and N-acyl-ethanolamine families, Flamand, N., Di Marzo, V., Dumais, É., Lavoie, J.-P.C., Archambault, A.-S., Simard, M., Biochemical Pharmacology, 2022, 10.1016/j.bcp.2022.115261

Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer, Izzo, A.A., Di Marzo, V., Piscitelli, F., Gallo, L., Capasso, R., Borrelli, F., Romano, B., Aviello, G., 2012, 10.1007/s00109-011-0856-x

Nonpsychotropic plant cannabinoids, Cannabidivarin (CBDV) and Cannabidiol (CBD), activate and desensitize Transient Receptor Potential Vanilloid 1 (TRPV1) channels in vitro: Potential for the treatment of neuronal hyperexcitability, Stephens, G.J., Di Marzo, V., Whalley, B.J., Russo, E., Mazzarella, E., Soubrane, C., Alhusaini, A., Leo, A., Hill, C.L., Iannotti, F.A., 2014, 10.1021/cn5000524

Development of the first potential covalent inhibitors of anandamide cellular uptake, Di Marzo, V., Ortar, G., Morera, E., Durand, T., Cascio, M.G., Ligresti, A., Balas, L., Moriello, A.S., 2006, 10.1021/jm051226l

Targeted lipidomics: Endocannabinoids and other endolipid modulators, Piomelli, D., Di Marzo, V., Makriyannis, A., Rapaka, R.S., 2005, 10.1016/j.lfs.2005.05.001

Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes, Di Marzo, V., Stott, C.G., Petrosino, S., Bisogno, T., Allarà, M., Moriello, A.S., Ligresti, A., De Petrocellis, L., 2011, 10.1111/bph.2011.163.issue-7

Gene-based microbiome representation enhances host phenotype classification, Frédéric Raymond, Vincenzo Di Marzo, Pier-Luc Plante, Fred Wilfried Elom Tohoundjona, Thomas Deschênes, mSystems, 2023, 10.1128/msystems.00531-23

Alterations of the endocannabinoid system and circulating and peripheral tissue levels of endocannabinoids in sarcopenic rats, Walrand, S., Di Marzo, V., Montaurier, C., Martin, V., Sanchez, P., Piscitelli, F., Salles, J., Le Bacquer, O., Journal of Cachexia, Sarcopenia and Muscle, 2022, 10.1002/jcsm.12855

Identification of endocannabinoids and cannabinoid CB₁ receptor mRNA in the pituitary gland, Fernández-Ruiz, J.J., Ramos, J.A., Di Marzo, V., Fuentes, J.A., Romero, J., Bisogno, T., Corchero, J., Wenger, T., Berrendero, F., Manzanares, J., González, S., Neuroendocrinology, 1999, 10.1159/000054468

Poly-ε-caprolactone microspheres as a drug delivery system for cannabinoid administration: Development, characterization and in vitro evaluation of their antitumoral efficacy, Torres Suárez, A.I., Di Marzo, V., Molpeceres, J., Aberturas, M.R., Gil-Alegre, M.E., Ligresti, A., Hernan Perez De La Ossa, D., 2012, 10.1016/j.jconrel.2012.05.003

Blood levels of the endocannabinoid anandamide are increased in anorexia nervosa and in binge-eating disorder, but not in bulimia nervosa, Di Marzo, V., De Petrocellis, L., Maj, M., Martiadis, V., Matias, I., Monteleone, P., 2005, 10.1038/sj.npp.1300695

Synthesis and binding study of certain 6-arylalkanamides as molecular probes for cannabinoid receptor subtypes, Abouzid, K.A., Abadi, A.H., Di Marzo, V., Allarà, M., Kadry, H.H., Taher, A.T., 2013, 10.3109/14756366.2011.645241

Editorial: New potential therapies from vanilloid transient receptor cation (TRPV) channels, Di Marzo, V., Starowicz, K., 2008, 10.2174/138161208783330736

Levels of endocannabinoids and palmitoylethanolamide and their pharmacological manipulation in chronic granulomatous inflammation in rats, Di Marzo, V., Iuvone, T., Orlando, P., Petrosino, S., Cipriano, M., D'Amico, A., De Filippis, D., 2010, 10.1016/j.phrs.2009.11.005

Endovanilloid signaling in pain, Szallasi, A., Blumberg, P.M., Di Marzo, V., 2002, 10.1016/S0959-4388(02)00340-9

The Activity of Anandamide at Vanilloid VR1 Receptors Requires Facilitated Transport across the Cell Membrane and Is Limited by Intracellular Metabolism, Di Marzo, V., Finazzi-Agrò, A., Davis, J.B., Maccarrone, M., Bisogno, T., De Petrocellis, L., 2001, 10.1074/jbc.M008555200

Polymorphism rs1761667 in the CD36 Gene Is Associated to Changes in Fatty Acid Metabolism and Circulating Endocannabinoid Levels Distinctively in Normal Weight and Obese Subjects, Iole Tomassini Barbarossa, Sebastiano Banni, Vincenzo Di Marzo, Claudia Manca, Elisabetta Murru, Carla A. Piras, Paolo Pintus, Stefano Pintus, Gianfranca Carta, Melania Melis, Frontiers in Physiology, 2017, 10.3389/fphys.2017.01006

A novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol with potential anti-obesity effects, Di Marzo, V., Moles, A., Cravatt, B., Lichtman, A., Giacovazzo, G., Chen, Y., Allarà, M., Chang, J.W., Coccurello, R., Mahadevan, A., Bisogno, T., 2013, 10.1111/bph.12013

Immunohistochemical localization of anabolic and catabolic enzymes for anandamide and other putative endovanilloids in the hippocampus and cerebellar cortex of the mouse brain, Di Marzo, V., Ueda, N., Guglielmotti, V., Morishita, J., De Petrocellis, L., Starowicz, K., Cristino, L., 2008, 10.1016/j.neuroscience.2007.11.047

The non-euphoric phytocannabinoid cannabidivarin counteracts intestinal inflammation in mice and cytokine expression in biopsies from UC pediatric patients, F. Borrelli, A.A. Izzo, V. Di Marzo, R. Capasso, P. Orlando, F. Lembo, G. Stocco, T. Venneri, M. Lucafò, L. Coretti, S. Pignatiello, M. D’Armiento, O.A. Parisi, F.A. Iannotti, B. Romano, E. Pagano, Pharmacological Research, 2019, 10.1016/j.phrs.2019.104464

CB1 cannabinoid receptors and on-demand defense against excitotoxicity, Lutz, B., Behl, C., Di Marzo, V., Zieglgänsberger, W., Schütz, G., Casanova, E., López-Rodríguez, M.L., Van der Stelt, M., Gutiérrez, S.O., Cascio, M.G., Azad, S.C., Cannich, A., Eder, M., Hermann, H., Monory, K., Goodenough, S., Marsicano, G., 2003, 10.1126/science.1088208

Single amino acid substitutions in the reactive site of antithrombin leading to thrombosis. Congenital substitution of arginine 393 to cysteine in antithrombin Northwick Park and to histidine in antithrombin Glasgow, Morris, H.R., Di Marzo, V., Lane, D.A., Panico, M., Erdjument, H., 1988

"De-liver-ance" from CB ₁ : A way to counteract insulin resistance?, Di Marzo, V., Gastroenterology, 2012, 10.1053/j.gastro.2012.03.011

A gradient of 2-arachidonoylglycerol regulates mouse epididymal sperm cell start-up., Di Marzo, V., Ledent, C., Pierantoni, R., Meccariello, R., Fasano, S., Altucci, L., Chioccarelli, T., De Petrocellis, L., Bisogno, T., Cascio, M.G., Petrosino, S., Orlando, P., Cacciola, G., Ricci, G., Cobellis, G., 2010, 10.1095/biolreprod.109.079210

Anandamide-derived prostamide F_2α negatively regulates adipogenesis, Di Marzo, V., Woodward, D.F., Izzo, A., Capasso, R., Piscitelli, F., Poloso, N.J., Martella, A., Silvestri, C., Journal of Biological Chemistry, 2013, 10.1074/jbc.M113.489906

CB₁ receptor antagonism: biological basis for metabolic effects, Di Marzo, V., Drug Discovery Today, 2008, 10.1016/j.drudis.2008.09.001

Fetal cannabinoid receptors and the "dis-joint-ed" brain, Di Marzo, V., Cristino, L., 2014, 10.1002/embj.201488086

The multiplicity of spinal AA-5-HT anti-nociceptive action in a rat model of neuropathic pain, Starowicz, K., Di Marzo, V., Przewlocka, B., Piscitelli, F., Kucharczyk, M., Pajak, A., Makuch, W., Malek, N., Kostrzewa, M., Pharmacological Research, 2016, 10.1016/j.phrs.2016.06.012

Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type-8, Di Marzo, V., Orlando, P., Marini, P., Magherini, P.C., Schiano-Moriello, A., Vellani, V., De Petrocellis, L., 2008, 10.1124/jpet.107.134809

Immunohistochemical localization of cannabinoid type 1 and vanilloid transient receptor potential vanilloid type 1 receptors in the mouse brain, Di Marzo, V., Guglielmotti, V., Baker, D., Pryce, G., de Petrocellis, L., Cristino, L., 2006, 10.1016/j.neuroscience.2006.02.074

Up-regulation of anandamide levels as an endogenous mechanism and a pharmacological strategy to limit colon inflammation, Di Marzo, V.D., Sorrentini, I., Cosenza, V., Scaglione, G., Valenti, M., D'Argenio, G., 2006, 10.1096/fj.05-4943fje

Anandamide and other cannabimimetic fatty acid derivatives — Foreword, Yamamoto, S., Di Marzo, V., Prostaglandins and Other Lipid Mediators, 2000, 10.1016/S0090-6980(00)00050-2

Endocannabinoids as regulators of transient receptor potential (TRP) channels: A further opportunity to develop new endocannabinoid-based therapeutic drugs, De Petrocellis, L., Di Marzo, V., 2010, 10.2174/092986710790980078

Cannabinoid CB₁ receptor antagonism prevents neurochemical and behavioural deficits induced by chronic phencyclidine, Parolaro, D., Di Marzo, V., Rubino, T., Binelli, G., Realini, N., Zamberletti, E., Petrosino, S., Viganò, D., Guidali, C., International Journal of Neuropsychopharmacology, 2011, 10.1017/S1461145710000209

Treatment With 2-Pentadecyl-2-Oxazoline Restores Mild Traumatic Brain Injury-Induced Sensorial and Neuropsychiatric Dysfunctions, Luongo, L., Maione, S., Di Marzo, V., Calignano, A., Giannella, M., Ricciardi, F., Infantino, R., Belardo, C., Guida, F., Bello, F.D., Iannotti, F.A., Cristiano, C., Iannotta, M., Boccella, S., Frontiers in Pharmacology, 2020, 10.3389/fphar.2020.00091

Endocannabinoids: Endogenous cannabinoid receptor ligands with neuromodulatory action, De Petrocellis, L., Bisogno, T., Melck, D., Di Marzo, V., 1998, 10.1016/S0166-2236(98)01283-1

Alterations of the endocannabinoid system by endocrine-disrupting chemicals: Effects on metabolism and reproduction, Carnevali, O., Di Marzo, V., Forner-Piquer, I., Environmental Contaminants and Endocrine Health, 2023, 10.1016/B978-0-12-824464-7.00018-0

Synthesis of novel 2-(1-adamantanylcarboxamido)thiophene derivatives. Selective cannabinoid type 2 (CB2) receptor agonists as potential agents for the treatment of skin inflammatory disease, Federico Corelli, Alessia Ligresti, Vincenzo Di Marzo, Roberta Verde, Stefania Petrosino, Nastasja Palombi, Antonella Brizzi, Alessandro Rabbito, Claudia Mugnaini, European Journal of Medicinal Chemistry, 2019, 10.1016/j.ejmech.2018.09.070

Decreased endocannabinoid levels in the brain and beneficial effects of agents activating cannabinoid and/or vanilloid receptors in a rat model of multiple sclerosis, Fernández-Ruiz, J., Di Marzo, V., Ramos, J.A., García-Merino, A., Valenti, M., Mestre, L., Sánchez, A., Fezza, F., De Lago, E., Venderova, K., Cabranes, A., 2005, 10.1016/j.nbd.2005.03.002

Antinociceptive effects of tetrazole inhibitors of endocannabinoid inactivation: Cannabinoid and non-cannabinoid receptor-mediated mechanisms, Di Marzo, V., Ortar, G., Luongo, L., Ligresti, A., Marabese, I., Morera, E., Maione, S., 2008, 10.1038/bjp.2008.308

Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity, Mario van der Stelt, Michelle Glass, Pal Pacher, Mauro Maccarrone, Aron H. Lichtman, Jürg Gertsch, Vincenzo Di Marzo, Mark Connor, Laura H. Heitman, Hui Deng, Elliot D. Mock, Andrea Martella, Marc P. Baggelaar, Georgios Alachouzos, Lizi Xia, Nicolina Mastrangelo, Henk de Vries, Jordyn Stuart, Marianela Dalghi Gens, Andrea Chicca, Christa MacDonald, David Finlay, Noortje van Gils, Camille Perret, Benno Rothenhäusler, Christoph Ullmer, Luciano de Petrocellis, Filomena Fezza, Travis W. Grim, Jürgen Fingerle, Uwe Grether, Marjolein Soethoudt, Nature Communications, 2017, 10.1038/ncomms13958

Opposing control of cannabinoid receptor stimulation on amyloid-β-induced reactive gliosis: In vitro and in vivo evidence, Steardo, L., Di Marzo, V., Papa, M., De Filippis, D., Scuderi, C., Savani, C., Iuvone, T., Esposito, G., 2007, 10.1124/jpet.107.121566

Rational drug design paradigms: The odyssey for designing better drugs, Mavromoustakos, T., Di Marzo, V., Langer, T., Bryant, S., Melagraki, G., Afantitis, A., Tzakos, A.G., Hadjikakou, S., Kokotos, G., Moutevelis-Minakakis, P., Liapakis, G., Vrontaki, E., Ntountaniotis, D., Kellici, T., Combinatorial Chemistry and High Throughput Screening, 2015

Sex steroid influence on cannabinoid CB₁ receptor mRNA and endocannabinoid levels in the anterior pituitary gland, Fernández-Ruiz, J.J., Ramos, J.A., Di Marzo, V., Berrendero, F., Milone, A., Manzanares, J., Wenger, T., Bisogno, T., González, S., Biochemical and Biophysical Research Communications, 2000, 10.1006/bbrc.2000.2406

Inhibitory effect of the anorexic compound oleoylethanolamide on gastric emptying in control and overweight mice, Izzo, A.A., Di Marzo, V., Capasso, F., Romano, B., Orlando, P., Borrelli, F., Petrosino, S., Capasso, R., Matias, I., Aviello, G., 2008, 10.1007/s00109-008-0305-7

Targeting the endocannabinoid system: To enhance or reduce?, Di Marzo, V., 2008, 10.1038/nrd2553

The biosynthesis of N-arachidonoyl dopamine (NADA), a putative endocannabinoid and endovanilloid, via conjugation of arachidonic acid with dopamine, Walker, J.M., Di Marzo, V., Cravatt, B.F., Roskoski Jr., R., Tan, B., Masuda, K., Bisogno, T., Minassi, A., Huang, S.M., Chen, J.S.-C., Benton, V.M., Bradshaw, H.B., Hu, S.S.-J., 2009, 10.1016/j.plefa.2009.05.026

Erratum: Corrigendum to Halogenation of a capsaicin analogue leads to novel vanilloid TRPVI receptor antagonists (British Journal Pharmacology (2003) 139 (1417-1424)), Di Marzo, V., Geppetti, P., Benvenuti, F., Trevisani, M., Moriello, A.S., Bianchi, F., Daddario, N., De Petrocellis, L., Harrison, S., Appendino, G., 2003, 10.1038/sj.bjp.0705565

The endocannabinoid system protects rat glioma cells against HIV-1 Tat protein-induced cytotoxicity: Mechanism and regulation, Iuvone, T., Di Marzo, V., Di Rosa, M., Ruvo, M., Bisogno, T., Izzo, A.A., Ligresti, A., Esposito, G., 2002, 10.1074/jbc.M207170200

Synthesis and molecular targets of N-13-hydroxy-octadienoyl-ethanolamine, a novel endogenous bioactive 15-lipoxygenase-derived metabolite of N-linoleoyl-ethanolamine found in the skin and saliva, Flamand, N., Di Marzo, V., Ligresti, A., De Petrocellis, L., Pouliot, R., Simard, M., Desjardins, Y., Plante, P.-L., Martin, C., Kostrzewa, M., Rakotoarivelo, V., Dumais, É., Archambault, A.-S., Tinto, F., Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 2021, 10.1016/j.bbalip.2021.158954

Antithrombin Chicago, amino acid substitution of arginine 393 to histidine, Rosenberg, R.D., Bauer, K., Morris, H.R., Di Marzo, V., Panico, M., Lane, D.A., Erdjument, H., 1989, 10.1016/0049-3848(89)90127-8

First Evidence of the Protective Effects of 2-Pentadecyl-2-Oxazoline (PEA-OXA) in In Vitro Models of Acute Lung Injury, Stefania Petrosino, Vincenzo Di Marzo, Roberta Verde, Rosa Camerlingo, Marco Allarà, Giuseppina Rea, Fabio Arturo Iannotti, Fiorentina Roviezzo, Aniello Schiano Moriello, Biomolecules, 2022, 10.3390/biom13010033

ω10-lipoxygenase products of α-linolenic acid are esterified to phospholipids in Hydra vulgaris, Cimino, G., De Petrocellis, L., Vardaro, R.R., Di Marzo, V., 1996, 10.1007/BF01923355

Palmitoylethanolamide, a naturally occurring lipid, is an orally effective intestinal anti-inflammatory agent, Izzo, A.A., Di Marzo, V., Orlando, P., Battista, G., Coppola, D., Capasso, R., Pagano, E., Petrosino, S., Romano, B., Borrelli, F., British Journal of Pharmacology, 2015, 10.1111/bph.12907

Effects of non-euphoric plant cannabinoids on muscle quality and performance of dystrophic mdx mice, Vincenzo Di Marzo, Luciano De Petrocellis, Elvira De Leonibus, Raffaele Capasso, Elisabetta Gazzerro, Luca D'Orsi, Nicolina Cristina Sorrentino, Filomena Grazia Alvino, Aniello Schiano Moriello, Ester Pagano, Fabio Arturo Iannotti, British Journal of Pharmacology, 2018, 10.1111/bph.14460

New quinolone- and 1,8-naphthyridine-3-carboxamides as selective CB2 receptor agonists with anticancer and immuno-modulatory activity, Bifulco, M., Macchia, M., Nieri, P., Di Marzo, V., Gazzerro, P., Pisanti, S., Ciaglia, E., Savinainen, J.R., Saccomanni, G., Ligresti, A., Laezza, C., Bertini, S., Fogli, S., Carpi, S., Lucchesi, V., Parkkari, T., Malfitano, A.M., Manera, C., European Journal of Medicinal Chemistry, 2015, 10.1016/j.ejmech.2015.04.034

Dose-Specific Effects of Di-Isononyl Phthalate on the Endocannabinoid System and on Liver of Female Zebrafish, Oliana Carnevali, Vincenzo Di Marzo, Hamid R Habibi, Fabiana Piscitelli, Marco Allarà, Stefania Santangeli, Giorgia Gioacchini, Francesca Maradonna, Isabel Forner-Piquer, Endocrinology, 2017, 10.1210/en.2017-00458

Erratum: "The hypothalamic levels of the endocannabinoid, anandamide, peak immediately before the onset of puberty in female rats" (Life Sciences (2002) 70:12 (1407-1414) PII: S0024320501015168), Di Marzo, V., Fernandez-Ruiz, J., Bisogno, T., González, S., Fezza, F., Gerendai, I., Wenger, T., 2002, 10.1016/S0024-3205(02)01800-3

Effect of dietary fat on endocannabinoids and related mediators: Consequences on energy homeostasis, inflammation and mood, di Marzo, V., Banni, S., 2010, 10.1002/mnfr.200900516

Up-regulation of the endocannabinoid system in the uterus of leptin knockout (ob/ob) mice and implications for fertility, Di Marzo, V., Mechoulam, R., Suris, R., Finazzi Agrò, A., Battista, N., Cascio, M.G., Bari, M., Bisogno, T., Fride, E., Maccarrone, M., 2005, 10.1093/molehr/gah130

The endocannabinoid signalling system: Biochemical aspects, Di Marzo, V., Ligresti, A., Bisogno, T., 2005, 10.1016/j.pbb.2005.01.027

Altered Metabolism of Phospholipases, Diacylglycerols, Endocannabinoids, and N-Acylethanolamines in Patients with Mastocytosis, Stefania Loffredo, Vincenzo Di Marzo, Massimo Triggiani, Giancarlo Marone, Gilda Varricchi, Maria Rosaria Galdiero, Roberta Parente, Angelica Petraroli, Fabiana Piscitelli, Anne Lise Ferrara, Journal of Immunology Research, 2019, 10.1155/2019/5836476

Synthesis and biological evaluation of piperazinyl carbamates and ureas as fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channel dual ligands, Ortar, G., Di Marzo, V., Woodward, D.F., Nalli, M., Ligresti, A., Moriello, A.S., Morera, L., De Petrocellis, L., Morera, E., 2009, 10.1016/j.bmcl.2009.09.033

Arachidonoylethyleneglycol and its nitroester as new cannabimimetics: Oxidation by 15-lipoxygenase and hydrolysis by fatty acid amide hydrolase, Manevich, Y., Di Marzo, V., Bisogno, T., De Petrocellis, L., Marvanov, D.M., Titova, O.Yu., Kogteva, G.S., Verevochkina, E.Yu., Fedenyuk, A.P., Serkov, I.V., Archakov, A.V., Gretskaya, N.M., Bobrov, M.Yu., Bezuglov, V.V., 1998

Orexin-A Prevents Lipopolysaccharide-Induced Neuroinflammation at the Level of the Intestinal Barrier, Letizia Palomba, Vincenzo Di Marzo, Luigia Cristino, Nataša Milić, Livia D'Angelo, Raffaele Capasso, Isabella Mavaro, Alba Clara Fernández-Rilo, Nicola Forte, Lea Tunisi, Frontiers in Endocrinology, 2019, 10.3389/fendo.2019.00219

An endogenous cannabinoid tone attenuates cholera toxin-induced fluid accumulation in mice, Di Marzo, V., Mascolo, N., Lutz, B., Cecio, A., Borrelli, F., Pinto, L., Capasso, R., Matias, I., Ligresti, A., Marsicano, G., Bisogno, T., Costagliola, A., Capasso, F., Izzo, A.A., 2003, 10.1016/S0016-5085(03)00892-8

Minireview: Interactions between second messengers: Cyclic AMP and phospholipase A₂- and phospholipase C-metabolites, Morris, H.R., Tippins, J.R., Galadari, S.H.I., Di Marzo, V., Life Sciences, 1991, 10.1016/0024-3205(91)90011-Y

The taming of capsaicin. Reversal of the vanilloid activity of N-acylvanillamines by aromatic iodination, Di Marzo, V., De Petrocellis, L., Moriello, A.S., Minassi, A., Daddario, N., Appendino, G., 2005, 10.1021/jm050139q

Questions and answers, Vermersch, P., Di Marzo, V., Haas, J., 2011, 10.1586/ern.11.28

At the heart of the matter: The endocannabinoid system in cardiovascular function and dysfunction, Di Marzo, V., Montecucco, F., 2012, 10.1016/j.tips.2012.03.002

Systemic administration of serotonin exacerbates abdominal pain and colitis via interaction with the endocannabinoid system, Jakub Fichna, Vincenzo Di Marzo, Wanda M. Krajewska, Radzislaw Kordek, Ewa Malecka-Panas, Roberta Verde, Adam I. Cygankiewicz, Anna Mokrowiecka, Fabiana Piscitelli, Agata Binienda, Maciej Salaga, Biochemical Pharmacology, 2019, 10.1016/j.bcp.2019.01.001

Why do cannabinoid receptors have more than one endogenous ligand?, De Petrocellis, L., Di Marzo, V., 2012, 10.1098/rstb.2011.0382

Endocannabinoids, Di Marzo, V., Fride, E., Mechoulam, R., 1998, 10.1016/S0014-2999(98)00649-9

Effects of metabolites of the analgesic agent dipyrone (metamizol) on rostral ventromedial medulla cell activity in mice, Imming, P., Di Marzo, V., De Petrocellis, L., Luongo, L., De Gregorio, D., Radanova, L., Maione, S., 2015, 10.1016/j.ejphar.2014.12.022

Care and feeding of the endocannabinoid system: A systematic review of potential clinical interventions that upregulate the endocannabinoid system, Di Marzo, V., Guy, G.W., McPartland, J.M., 2014, 10.1371/journal.pone.0089566

Homology modeling in tandem with 3D-QSAR analyses: A computational approach to depict the agonist binding site of the human CB2 receptor, Fossa, P., Ranise, A., Spallarossa, A., Milanesi, L., Marabotti, A., D'Ursi, P., Lazzati, Z., Di Marzo, V., Allar, M., Ligresti, A., Cichero, E., 2011, 10.1016/j.ejmech.2011.07.023

Endocannabinoid metabolic pathways and enzymes, Di Marzo, V., Cascio, M.G., Ligresti, A., 2005

The sleep inducing factor oleamide is produced by mouse neuroblastoma cells, Di Marzo, V., Mechoulam, R., De Petrocellis, L., Sepe, N., Bisogno, T., 1997, 10.1006/bbrc.1997.7431

Oxytoxins, bioactive molecules produced by the marine opisthobranch mollusc Oxynoe olivacea from a diet-derived precursor, Ros, J.D., Gavagnin, M., Di Marzo, V., Crispino, A., Cimino, G., 1990, 10.1007/BF01939963

Endocannabinoids in amygdala and nucleus accumbens mediate social play reward in adolescent rats, Vanderschuren, L.J.M.J., Di Marzo, V., Cuomo, V., Campolongo, P., Zhou, Y., Jeroen Pasterkamp, R., van Kerkhof, L.W.M., Petrosino, S., Manduca, A., Damsteegt, R., Trezza, V., 2012, 10.1523/JNEUROSCI.0114-12.2012

Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1, Glass, R., Kettenmann, H., Di Marzo, V., Cristino, L., De Petrocellis, L., Ligresti, A., Lewin, G.R., Momma, S., Cravatt, B.F., Dittmar, G., Chirasani, S.R., Wälzlein, J.-H., Matyash, V., Gurok, U., Nuber, U.A., Purfürst, B., Wend, P., Smith, E.S.J., Imperatore, R., Petrosino, S., Synowitz, M., Kumar, J., Stock, K., 2012, 10.1038/nm.2827

N-palmitoyl-d-glucosamine, a natural monosaccharide-based glycolipid, inhibits tlr4 and prevents lps-induced inflammation and neuropathic pain in mice, Guida, F., Maione, S., Luongo, L., Di Marzo, V., D’amico, M., Cristino, L., Tunisi, L., Amodeo, P., Panarese, I., Ferraraccio, F., Mirto, B.F., Ricciardi, F., Infantino, R., Boccella, S., Maisto, R., Vitale, R.M., Iannotti, F.A., Trotta, M.C., Belardo, C., Iannotta, M., International Journal of Molecular Sciences, 2021, 10.3390/ijms22031491

Gender-dependent cellular and biochemical effects of maternal deprivation on the hippocampus of neonatal rats: A possible role for the endocannabinoid system, Viveros, M.-P., Di Marzo, V., López-Gallardo, M., Prada, C., Guaza, C., Marco, E.-M., Petrosino, S., Llorente-Berzal, A., Llorente, R., 2008, 10.1002/dneu.20666

New 1,8-naphthyridine and quinoline derivatives as CB₂ selective agonists, Ferrarini, P.L., Di Marzo, V., Ghelardini, C., Vivoli, E., Saccomanni, G., Martinelli, A., Tuccinardi, T., Allarà, M., Benetti, V., Cascio, M.G., Manera, C., Bioorganic and Medicinal Chemistry Letters, 2007, 10.1016/j.bmcl.2007.09.089

Mgll Knockout Mouse Resistance to Diet-Induced Dysmetabolism Is Associated with Altered Gut Microbiota, Cristoforo Silvestri, Vincenzo Di Marzo, Nadine Leblanc, Armita Abolghasemi, Thomas Deschênes, Ulrike Taschler, Sébastien Lacroix, Niokhor Dione, Cells, 2020, 10.3390/cells9122705

Lipopolysaccharide downregulates fatty acid amide hydrolase expression and increases anandamide levels in human peripheral lymphocytes, Finazzi-Agrò, A., Di Marzo, V., Salvati, S., Fezza, F., Bari, M., De Petrocellis, L., Maccarrone, M., 2001, 10.1006/abbi.2001.2500

Circulating endocannabinoid levels, abdominal adiposity and related cardiometabolic risk factors in obese men, Di Marzo, V., Després, J.-P., Alméras, N., Petrosino, S., Lemieux, I., Matias, I., Côté, M., 2007, 10.1038/sj.ijo.0803539

Effect of vasoactive intestinal peptide and calcitonin gene-related peptide on leukotriene release from guinea pig and rat lung., Morris, H.R., Di Marzo, V., Tippins, J.R., 1987

Endocannabinoids and β-amyloid-induced neurotoxicity in vivo: Effect of pharmacological elevation of endocannabinoid levels, Di Marzo, V., Iuvone, T., Drago, F., Steardo, L., Micale, V., De Filippis, D., Petrosino, S., Matias, I., Esposito, G., Mazzola, C., Van Der Stelt, M., 2006, 10.1007/s00018-006-6037-3

Cannabimovone, a cannabinoid with a rearranged terpenoid skeleton from hemp, Appendino, G., Grassi, G., Di Marzo, V., De Petrocellis, L., Scala, F., Pagani, A., Taglialatela-Scafati, O., 2010, 10.1002/ejoc.200901464

Biosynthesis of anandamide and related acylethanolamides in mouse J774 macrophages and N₁₈ neuroblastoma cells, Buono, A., Sepe, N., De Petrocellis, L., Di Marzo, V., Biochemical Journal, 1996, 10.1042/bj3160977

Design, Synthesis, and Physicochemical and Pharmacological Profiling of 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Derivatives with Antiosteoarthritic Activity in Vivo, Corelli, F., Ligresti, A., Di Marzo, V., Starowicz, K., Mor, M., Colombo, G., MacCioni, P., Vacondio, F., Ferlenghi, F., Giorgi, G., Lamponi, S., Brizzi, A., Mahmoud, A.M., Bryk, M., Kostrzewa, M., Mugnaini, C., Journal of Medicinal Chemistry, 2020, 10.1021/acs.jmedchem.0c00595

Chronic morphine modulates the contents of the endocannabinoid, 2-arachidonoyl glycerol, in rat brain, Parolaro, D., Di Marzo, V., Vaccani, A., Fezza, F., Rubino, T., Cascio, M.G., Viganò, D., Neuropsychopharmacology, 2003, 10.1038/sj.npp.1300117

Lipids in neural function: modulation of behavior by oral administration of endocannabinoids found in foods., Mechoulam, R., Fride, E., De Petrocellis, L., Bisogno, T., Di Marzo, V., Berger, A., Crozier Willi, G., 2001

Inhibiting endocannabinoid biosynthesis: A novel approach to the treatment of constipation, Sharkey, K.A., Di Marzo, V., Storr, M.A., Mackie, K., Nalli, M., Piscitelli, F., Ho, W., Keenan, C.M., Nasser, Y., Bashashati, M., British Journal of Pharmacology, 2015, 10.1111/bph.13114

Anandamide, an endogenous cannabinomimetic substance, modulates rat brain protein kinase C in vitro, Di Marzo, V., Orlando, P., De Petrocellis, L., 1995

Role of Bisphenol A on the Endocannabinoid System at central and peripheral levels: Effects on adult female zebrafish, Oliana Carnevali, Hamid R. Habibi, Vincenzo di Marzo, Fabiana Piscitelli, Roberta Verde, Francesca Maradonna, Stefania Santangeli, Isabel Forner-Piquer, Chemosphere, 2018, 10.1016/j.chemosphere.2018.04.078

Control by the endogenous cannabinoid system of ras oncogene-dependent tumor growth., Di Marzo, V., De Petrocellis, L., Orlando, P., Vitale, M., Portella, G., Laezza, C., Bifulco, M., 2001

Manipulation of the endocannabinoid system by a general anaesthetic, Di Marzo, V., 2003, 10.1038/sj.bjp.0705333

Mutual Links between the Endocannabinoidome and the Gut Microbiome, with Special Reference to Companion Animals: A Nutritional Viewpoint, Stefania Petrosino, Vincenzo Di Marzo, Aniello Schiano Moriello, Animals, 2022, 10.3390/ani12030348

Endocannabinoids and endocannabinoid-related mediators: Targets, metabolism and role in neurological disorders, Petrosino, S., Di Marzo, V., Iannotti, F.A., Progress in Lipid Research, 2016, 10.1016/j.plipres.2016.02.002

The effects of anandamide on memory consolidation in mice involve both D₁ and D₂ dopamine receptors, Puglisi-Allegra, S., Di Marzo, V., Palmisano, A., Cabib, S., Castellano, C., Behavioural Pharmacology, 1997, 10.1097/00008877-199712000-00005

Targeting gut dysbiosis against inflammation and impaired autophagy in Duchenne muscular dystrophy, Iannotti, F.A., Di Marzo, V., Russo, R., Motta, A., Capasso, R., Silvestri, C., Gazzerro, E., Abolghasemi, A., Piscitelli, F., Moriello, C., Cuozzo, M., Panza, E., Paris, D., Pagano, E., Kalkan, H., EMBO Molecular Medicine, 2023, 10.15252/emmm.202216225

Summary of the International Conference on Onco-Nephrology: an emerging field in medicine, Zecchino, O., Xiaoqiang, D., Więcek, A., Weisz, A., Troiani, T., Stadler, W., Siu, L.L., Russo, D., Remuzzi, G., Procopio, G., Porta, C., Pitts, T., Pisano, C., Perna, A., Perazella, M.A., Pani, A., Orditura, M., Costa, A.N., Morgillo, F., Mirone, V., Messina, C., Messa, P., Matsubara, T., Matarese, G., Martinelli, E., Marino, G., Malysxko, J., Mallamaci, F., Maiello, E., Launay-Vacher, V., Kuo, C., Gambaro, G., Gallieni, M., Franco, R., Fouque, D., Falco, G., Ereditato, A., De Vita, F., D'Errico, A., Daniele, B., Cosmai, L., Citterio, F., Cervantes, A., Cartenì, G., Caraglia, M., Ciardiello, F., Camussi, G., Bonventre, J.V., Biancone, L., Eri, K., Barone, V., Amer, H., Altucci, L., Alexander, T.R., Alahoti, A., Akitaka, A., Capasso, G., Zoccali, C., Viggiano, D., Trepiccione, F., Rosner, M.H., Ronco, P., Qian, Q., Perazella, M.A., Malyszko, J., Jaimes, E.A., Grandaliano, G., Gesualdo, L., Di Marzo, V., Danesh, F.R., Capitanio, U., Benigni, A., Capasso, A., Kidney International, 2019, 10.1016/j.kint.2019.04.043

1,2-Dihydro-2-oxopyridine-3-carboxamides: The C-5 substituent is responsible for functionality switch at CB2 cannabinoid receptor, Manera, C., Macchia, M., Di Marzo, V., Bifulco, M., Saccomanni, G., Ligresti, A., Laezza, C., Del Carlo, S., Castelli, F., Bertini, S., Allarà, M., Malfitano, A.M., Savinainen, J.R., Parkkari, T., Lucchesi, V., 2014, 10.1016/j.ejmech.2013.10.070

Native opioid-like peptides in Squilla mantis ganglia, Miralto, A., Melck, D., Di Marzo, V., Palmisano, A., Marino, G., 1985, 10.1016/0196-9781(85)90405-X

Novel bioactive metabolites of dipyrone (metamizol), Imming, P., Nüsing, R., Di Marzo, V., Bisogno, T., Cascio, M.G., Lichtman, A.H., Schlosburg, J., Watzer, B., Podlewski, A., Sinning, C., Rogosch, T., 2012, 10.1016/j.bmc.2011.11.028

Forebrain-specific inactivation of G_q/G₁₁ family G proteins results in age-dependent epilepsy and impaired endocannabinoid formation, Offermanns, S., Di Marzo, V., Schütz, G., Petrosino, S., Moers, A., Krestel, H., Tsubokawa, H., Van Der Stelt, M., Wettschureck, N., Molecular and Cellular Biology, 2006, 10.1128/MCB.00397-06

Chronic treatment with krill powder reduces plasma triglyceride and anandamide levels in mildly obese men, Di Marzo, V., Banni, S., Meyer, I., Silvestri, C., Hoem, N., Piscitelli, F., Berge, K., 2013, 10.1186/1476-511X-12-78

Indole-2-carboxamides as allosteric modulators of the cannabinoid CB ₁ receptor, Silvestri, R., Di Marzo, V., Novellino, E., Allarà, M., Morera, L., Coluccia, A., La Regina, G., Ligresti, A., Piscitelli, F., Journal of Medicinal Chemistry, 2012, 10.1021/jm201485c

Highly selective CB₁cannabinoid receptor ligands and novel CB₁/VR₁vanilloid receptor ୀhybridୁ ligands, Martin, B.R., Razdan, R.K., Mahadevan, A., Dasse, O., Davis, J.B., Winckler, R.L., Jefferson, R.G., Brandi, I., De Petrocellis, L., Bisogno, T., Di Marzo, V., Biochemical and Biophysical Research Communications, 2001, 10.1006/bbrc.2001.4354

Protective Effects of N-Oleoylglycine in a Mouse Model of Mild Traumatic Brain Injury, Di Marzo, V., Maione, S., Mechoulam, R., Parker, L.A., Lichtman, A.H., Cristino, L., Smoum, R., Imperatore, R., Lauritano, A., Verde, R., Boccella, S., Iannotti, F.A., Luongo, L., Guida, F., Piscitelli, F., ACS Chemical Neuroscience, 2020, 10.1021/acschemneuro.9b00633

Astrocytes modulate neuronal development by S100A6 signaling, Tibor Harkany, Alexei Verkhratsky, Vincenzo Di Marzo, Erik Keimpema, Fabiana Piscitelli, Daniela Calvigioni, Valentina Cinquina, 2023, 10.1101/2023.09.05.556314

Bioactive long chain N-acetylethanolamines in five species of edible bivalve molluscs. Possible implications for mollusc physiology and sea food industry, Di Marzo, V., Cimino, G., Montanaro, F., De Petrocellis, L., Sepe, N., 1998, 10.1016/S0005-2760(97)00132-X

A multi-target approach for pain treatment: Dual inhibition of fatty acid amide hydrolase and TRPV1 in a rat model of osteoarthritis, Starowicz, K., Di Marzo, V., Morera, E., Czaja, M., Binkowski, M., Przewlocka, B., Kolosowska, N., Makuch, W., Mrugala, M., Malek, N., Pain, 2015, 10.1097/j.pain.0000000000000132

A role for vanilloid receptor 1 (TRPV1) and endocannabinnoid signalling in the regulation of spontaneous and L-DOPA induced locomotion in normal and reserpine-treated rats, Brotchie, J.M., Di Marzo, V., Lee, J., 2006, 10.1016/j.neuropharm.2006.04.016

Molecular targets for cannabidiol and its synthetic analogues: Effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide, Di Marzo, V., Mechoulam, R., Davis, J.B., Moriello, A.S., Brandi, I., Ponde, D.E., Tchilibon, S., De Petrocellis, L., Hanuš, L., Bisogno, T., 2001

Novel selective and metabolically stable inhibitors of anandamide cellular uptake, Di Marzo, V., Morera, E., De Petrocellis, L., Ligresti, A., Ortar, G., 2003, 10.1016/S0006-2952(03)00109-6

Prostaglandin 1,15-Lactones of the F Series from the Nudibranch Mollusc Tethys fimbria, Sodano, G., Spinella, A., Marzo, V.D., Crispino, A., Cimino, G., Journal of Organic Chemistry, 1991, 10.1021/jo00008a056

Endocannabinoid dysregulation in the pancreas and adipose tissue of mice fed with a high-fat diet, Di Marzo, V., Izzo, A.A., Racioppi, A., Capasso, R., Matias, I., Cristino, L., Starowicz, K.M., 2008, 10.1038/oby.2007.106

Histological and biochemical bases of defense mechanisms in four species of Polybranchioidea ascoglossan molluscs, Cimino, G., Villani, G., De Petrocellis, L., Vardaro, R.R., Marin, A., Di Marzo, V., Marine Biology, 1993, 10.1007/BF00349312

Peripheral Endocannabinoid Responses to Hedonic Eating in Binge-Eating Disorder, , Nutrients, 2017, 10.3390/nu9121377

Preface, Wang, J.W., Di Marzo, V., The Endocannabinoidome: The World of Endocannabinoids and Related Mediators, 2015, 10.1016/B978-0-12-420126-2.00016-X

Presence and regulation of the endocannabinoid system in human dendritic cells, Di Marzo, V., Pestel, J., Salzet, M., Orlando, P., Pochard, P., Matias, I., 2002, 10.1046/j.1432-1033.2002.03078.x

Changes in endocannabinoid transmission in the basal ganglia in a rat model of Huntington's disease, Marzo, V.D., Fernández-Ruiz, J., Milone, A., Ramos, J.A., Bisogno, T., Cebeira, M., Fezza, F., Lastres-Becker, I., NeuroReport, 2001, 10.1097/00001756-200107200-00017

Endocannabinoids, feeding and suckling - From our perspective, Fride, E., Di Marzo, V., Avraham, Y., Berry, E.M., Mechoulam, R., 2006, 10.1038/sj.ijo.0803274

Neuroprotection by the endogenous cannabinoid anandamide and arvanil against in vivo excitotoxicity in the rat: Role of vanilloid receptors and lipoxygenases, Di Marzo, V., Nicolay, K., Bär, P.R., Vliegenthart, J.F.G., Veldink, G.A., Fezza, F., Maccarrone, M., Van Zadelhoff, G., Wadman, M.W., Van der Stelt, M., Veldhuis, W.B., 2003

Targeted Lipidomics Investigation of N ‐acylethanolamines in a Transgenic Mouse Model of AD: A Longitudinal Study, Mauro Maccarrone, Tiziana Bisogno, Sergio Oddi, Vincenzo Di Marzo, Roberto Giacominelli Stuffler, Nicola Ferri, Michele Podaliri Vulpiani, Emanuela Rossi, Roberta Verde, Giacomo Giacovazzo, Alessandro Leuti, Antonio Totaro, Roberto Coccurello, Fabiana Piscitelli, European Journal of Lipid Science and Technology, 2019, 10.1002/ejlt.201900015

Neuromodulatory actions of endocannabinoids in pain and sedation, Di Marzo, V., Bisogno, T., De Petrocellis, L., 2003

Synthesis and biological evaluation of [6]-gingerol analogues as transient receptor potential channel TRPV1 and TRPA1 modulators, Ortar, G., Di Marzo, V., Nalli, M., Moriello, A.S., Morera, L., De Petrocellis, L., Morera, E., 2012, 10.1016/j.bmcl.2011.12.113

Antithrombin Sheffield: amino acid substitution at the reactive site (Arg393 to His) causing thrombosis, Preston, F.E., Dolan, G., Greaves, M., Morris, H.R., Panico, M., Di Marzo, V., Flynn, A., Erdjument, H., Lane, D.A., 1989

Anandamide acts as an intracellular messenger amplifying Ca²⁺ influx via TRPV1 channels, Di Marzo, V., Geppetti, P., McNaughton, P., Campi, B., Moriello, A.S., De Petrocellis, L., Vellani, V., Trevisani, M., Van Der Stelt, M., EMBO Journal, 2005, 10.1038/sj.emboj.7600784

Depolarization-induced retrograde synaptic inhibition in the mouse cerebellar cortex is mediated by 2-arachidonoylglycerol, Freiman, I., Baer, W.U., Mendiguren, A., Di Marzo, V., Bisogno, T., Urbanski, M.J., Szabo, B., 2006, 10.1113/jphysiol.2006.119362

Effects of repeated lysergic acid diethylamide (LSD) on the mouse brain endocannabinoidome and gut microbiome, Di Marzo, V., Gobbi, G., Silvestri, C., Comai, S., Rogers, G., Flamand, N., De Gregorio, D., Abolghasemi, A., Grant, E., Markopolous, A., Choo, J., Bertazzo, A., Lacroix, S., Giorgini, G., Inserra, A., British Journal of Pharmacology, 2023, 10.1111/bph.15977

Positive association between plasmatic levels of orexin A and the endocannabinoid-derived 2-arachidonoyl lysophosphatidic acid in Alzheimer’s disease, Cristino, L., Di Marzo, V., Di Costanzo, A., De Girolamo, P., Piscitelli, F., Marfella, B., Palomba, L., Fernández-Rilo, A.C., Forte, N., Frontiers in Aging Neuroscience, 2022, 10.3389/fnagi.2022.1004002

Endocannabinoids activate transient receptor potential vanilloid 1 receptors to reduce hyperdopaminergia-related hyperactivity: Therapeutic implications, Giros, B., Nomikos, G.G., Phebus, L.A., Di Marzo, V., Bisogno, T., Moutsimilli, L., Li, D.L., Tzavara, E.T., 2006, 10.1016/j.biopsych.2005.08.019

Inhibitory effect of salvinorin A, from Salvia divinorum, on ileitis-induced hypermotility: Cross-talk between κ-opioid and cannabinoid CB ₁ receptors, Izzo, A.A., Capasso, F., Di Marzo, V., Romano, B., Marini, P., Zjawiony, J.K., Huben, K., Aviello, G., Cascio, M.G., Borrelli, F., Capasso, R., British Journal of Pharmacology, 2008, 10.1038/bjp.2008.294

Erratum: Correction to Design, Synthesis, and Physicochemical and Pharmacological Profiling of 7-Hydroxy-5-oxopyrazolo[4,3- b]pyridine-6-carboxamide Derivatives with Antiosteoarthritic Activity in Vivo (Journal of Medicinal Chemistry (2020) 63:(13);7369-7391. (DOI: 10.1021/acs.jmedchem.0c00595), Corelli, F., Ligresti, A., Di Marzo, V., Starowicz, K., Mor, M., Colombo, G., Maccioni, P., Vacondio, F., Ferlenghi, F., Giorgi, G., Lamponi, S., Brizzi, A., Mahmoud, A.M., Bryk, M., Kostrzewa, M., Mugnaini, C., Journal of Medicinal Chemistry, 2020, 10.1021/acs.jmedchem.0c01567

Synthesis and biological evaluation of phorbol-resiniferatoxin (RTX) hybrids, Di Marzo, V., De Petrocellis, L., Szallasi, A., Annunziata, R., Minassi, A., Bertolino, A., Appendino, G., 2004, 10.1002/ejoc.200400122

Targeting fatty acid amide hydrolase and transient receptor potential vanilloid-1 simultaneously to modulate colonic motility and visceral sensation in the mouse: A pharmacological intervention with N-arachidonoyl-serotonin (AA-5-HT), M. Storr, V. Di Marzo, N. Vergnolle, N. Cenac, J.-P. Timmermans, A. Sibaev, A. A. Izzo, R. Capasso, F. Piscitelli, J. Fichna, M. Bashashati, Neurogastroenterology & Motility, 2017, 10.1111/nmo.13148

Activation of cannabinoid type 1 receptor (CB1) modulates oligodendroglial process branching complexity in rat hippocampal cultures stimulated by olfactory ensheathing glia-conditioned medium, Sampaio, L.S., De Melo Reis, R.A., Carvalho, L.A., Tannous, B.A., Di Marzo, V., de Siqueira-Santos, R., Einicker-Lamas, M., de Mello, F.G., Allodi, S., de Aguiar, A.F.L., Isaac, A.R., Campos, R.M.P., Iannotti, F.A., Piscitelli, F., Vitorino, L.C., Trindade, P.M.P., Paes-Colli, Y., Frontiers in Cellular Neuroscience, 2023, 10.3389/fncel.2023.1134130

Changes in plasma endocannabinoid levels in viscerally obese men following a 1 year lifestyle modification programme and waist circumference reduction: Associations with changes in metabolic risk factors, Després, J.-P., Alméras, N., Petrosino, S., Piscitelli, F., Cartier, A., Arsenault, B.J., Lemieux, I., Matias, I., Côté, M., Di Marzo, V., 2009, 10.1007/s00125-008-1178-6

Biosynthesis of the novel endogenous 15-lipoxygenase metabolites N-13-hydroxy-octodecadienoyl-ethanolamine and 13-hydroxy-octodecadienoyl-glycerol by human neutrophils and Eosinophils, Flamand, N., Di Marzo, V., Ligresti, A., Vitale, R.M., Boulet, L.-P., Laviolette, M., Pouliot, R., Silvestri, C., Simard, M., Martin, C., Plante, P.-L., Kostrzewa, M., Rakotoarivelo, V., Dumais, É., Tinto, F., Archambault, A.-S., Cells, 2021, 10.3390/cells10092322

FAAH and MAGL inhibitors: Therapeutic opportunities from regulating endocannabinoid levels, Di Marzo, V., Petrosino, S., 2010

Involvement of the endocannabinoid system in phencyclidine-induced cognitive deficits modelling schizophrenia, Parolaro, D., Di Marzo, V., Rubino, T., Realini, N., Petrosino, S., Guidali, C., Vigano, D., 2009, 10.1017/S1461145708009371

Elongation of the Hydrophobic Chain as a Molecular Switch: Discovery of Capsaicin Derivatives and Endogenous Lipids as Potent Transient Receptor Potential Vanilloid Channel 2 Antagonists, Luciano De Petrocellis, Vincenzo Di Marzo, Rosa Maria Vitale, Ramon Canela-Garayoa, Pietro Amodeo, Jordi Eras, Olalla Novo Fernández, Silvia López Chinarro, Aniello Schiano Moriello, Journal of Medicinal Chemistry, 2018, 10.1021/acs.jmedchem.8b00734

Biosynthesis and inactivation of N-arachidonoylethanolamine (anandamide) and N-docosahexaenoylethanolamine in bovine retina, Di Marzo, V., Lagarde, M., Milone, A., Delton-Vandenbroucke, I., Bisogno, T., 1999, 10.1006/abbi.1999.1410

Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's disease, Brotchie, J.M., Crossman, A.R., Bisogno, T., Hill, M.P., Di Marzo, V., 2000

Inhibitory effect of positively charged triazine antagonists of prokineticin receptors on the transient receptor vanilloid type-1 (TRPV1) channel, Di Marzo, V., Balboni, G., Onnis, V., Congiu, C., Deplano, A., Zamponi, G.W., Zhang, F.-X., Messeguer, A., Garrido, M., Vázquez-Romero, A., Lee, J.Y., Sohn, J.M., Byun, J.S., Schiano Moriello, A., De Petrocellis, L., Pharmacological Research, 2015, 10.1016/j.phrs.2015.07.009

Effect of the Cannabinoid Receptor-1 antagonist SR141716A on human adipocyte inflammatory profile and differentiation, Roche, R., Hoareau, L., Cesari, M., Di Marzo, V., Petrosino, S., Gonthier, M.-P., Tallet, F., Bhattacharya, A., Gence, L., Bencharif, K., Murumalla, R., 2011, 10.1186/1476-9255-8-33

Investigations on the 4-Quinolone-3-carboxylic acid motif. 3. Synthesis, structure-affinity relationships, and pharmacological characterization of 6-substituted 4-quinolone-3-carboxamides as highly selective cannabinoid-2 receptor ligands, Corelli, F., Di Marzo, V., Maione, S., Pertwee, R., Marini, P., Bolognini, D., Cascio, M.G., De Chiaro, M., Luongo, L., Guida, F., De Rosa, M., Semeraro, T., Cicione, L., Mugnaini, C., Ligresti, A., Pasquini, S., 2010, 10.1021/jm100123x

Palmitoylethanolamide counteracts substance P-induced mast cell activation in vitro by stimulating diacylglycerol lipase activity, Di Marzo, V., Iannotti, F.A., Peritore, A.F., Mahmoud, A.M., Ligresti, A., Imperatore, R., Allarà, M., Verde, R., Schiano Moriello, A., Petrosino, S., Journal of Neuroinflammation, 2019, 10.1186/s12974-019-1671-5

Corrigendum to “Systemic administration of serotonin exacerbates abdominal pain and colitis via interaction with the endocannabinoid system” [Biochem. Pharmacol. 161 (2019) 37–51], Jakub Fichna, Vincenzo Di Marzo, Wanda M. Krajewska, Radzislaw Kordek, Ewa Malecka-Panas, Roberta Verde, Adam I. Cygankiewicz, Anna Mokrowiecka, Fabiana Piscitelli, Agata Binienda, Maciej Salaga, Biochemical Pharmacology, 2019, 10.1016/j.bcp.2019.113636

The endocannabinoid system in energy homeostasis and the etiopathology of metabolic disorders, Di Marzo, V., Silvestri, C., 2013, 10.1016/j.cmet.2013.03.001

Neural contractions in colonic strips from patients with diverticular disease: Role of endocannabinoids and substance P, Croci, T., Di Marzo, V., Ferla, G., Di Palo, S., Bianchetti, A., Matias, I., Mukenge, S., Valenti, M., Guagnini, F., 2006, 10.1136/gut.2005.076372

Anandamide as an intracellular messenger regulating ion channel activity, Di Marzo, V., Van Der Stelt, M., 2005, 10.1016/j.prostaglandins.2004.09.007

Two non-psychoactive cannabinoids reduce intracellular lipid levels and inhibit hepatosteatosis, Di Marzo, V., Motta, A., Cawthorne, M., Guadagnino, I., Melck, D., Martella, A., Paris, D., Silvestri, C., Journal of Hepatology, 2015, 10.1016/j.jhep.2015.01.001

Cannabinoid CB₁ receptor stimulation affords neuroprotection in MPTP-induced neurotoxicity by attenuating S100B up-regulation in vitro, Steardo, L., Di Marzo, V., Scuderi, C., Petrosino, S., Bisogno, T., De Filippis, D., Esposito, G., Iuvone, T., Journal of Molecular Medicine, 2007, 10.1007/s00109-007-0233-y

Meet our editor, Di Marzo, V., Recent Patents on CNS Drug Discovery, 2015

Cannabimimetic fatty acid derivatives in cancer and inflammation, Bisogno, T., De Petrocellis, L., Melck, D., Di Marzo, V., 2000, 10.1016/S0090-6980(00)00054-X

Further evidence for the existence of a specific process for the membrane transport of anandamide, Di Marzo, V., Ortar, G., Lutz, B., Monory, K., Van Der Stelt, M., Morera, E., Ligresti, A., 2004, 10.1042/BJ20031812

Anandamide: Some like it hot, De Petrocellis, L., Bisogno, T., Di Marzo, V., 2001, 10.1016/S0165-6147(00)01712-0

Synthesis and biological evaluation of novel amides of polyunsaturated fatty acids with dopamine, Durand, T., Vidal, J.-P., Rossi, J.-C., Kuklev, D., Di Marzo, V., Bisogno, T., Melck, D., Zinchenko, G., Gonchar, A., Gretskaya, N., Bobrov, M., Bezuglov, V., 2001, 10.1016/S0960-894X(00)00689-2

Metabolically labile cannabinoid esters: A 'soft drug' approach for the development of cannabinoid-based therapeutic drugs, Macchia, M., Di Marzo, V., Bifulco, M., Digiacomo, M., Bertini, S., Prota, G., Bisogno, T., Carboni, I., Cascio, M.G., Minutolo, F., 2007, 10.1016/j.bmcl.2007.06.055

Development of a Rapid LC-MS/MS Method for the Quantification of Cannabidiol, Cannabidivarin, Δ9-Tetrahydrocannabivarin, and Cannabigerol in Mouse Peripheral Tissues, Vincenzo Di Marzo, Angelo A. Izzo, Anna Lauritano, Ester Pagano, Fabiana Piscitelli, Analytical Chemistry, 2017, 10.1021/acs.analchem.7b01094

Placebo Effects in a Multiple Sclerosis Spasticity Enriched Clinical Trial with the Oromucosal Cannabinoid Spray (THC/CBD): Dimension and Possible Causes, Centonze, D., Di Marzo, V., CNS Neuroscience and Therapeutics, 2015, 10.1111/cns.12358

Analogues of perillaketone as highly potent agonists of TRPA1 channel, Di Marzo, V., Schiano Moriello, A., De Petrocellis, L., Morini, G., Borgonovo, G., Bassoli, A., 2013, 10.1016/j.foodchem.2013.05.063

Editorial, Di Marzo, V., 2013, 10.2174/1574889811308010001

Leptin-regulated endocannabinoids are involved in maintaining food intake, Kunos, G., Sugiura, T., Palmiter, R.D., Miura, G.I., Fezza, F., Járai, Z., Bátkai, S., Liu, J., Wang, L., Goparaju, S.K., Di Marzo, V., 2001, 10.1038/35071088

In Silico-Guided Rational Drug Design and Synthesis of Novel 4-(Thiophen-2-yl)butanamides as Potent and Selective TRPV1 Agonists, Artese, A., Alcaro, S., Di Marzo, V., Corelli, F., Maione, S., Scorzelli, F., Mugnaini, C., Moriello, A.S., Paolino, M., Maramai, S., Luongo, L., Frosini, M., De Petrocellis, L., Costa, G., Carullo, G., Belardo, C., Aiello, F., Ambrosio, F.A., Pessina, F., Brizzi, A., Romeo, I., Journal of Medicinal Chemistry, 2023, 10.1021/acs.jmedchem.3c00447

Erratum to: Cannabinoids in the Treatment of Neurological Disorders(Neurotherapeutics, Doi:10.1007/s13311-015-0388-0), Di Marzo, V., Whalley, B.J., Devinsky, O., Neurotherapeutics, 2015, 10.1007/s13311-015-0392-4

Anandamide and diet: Inclusion of dietary arachidonate and docosahexaenoate leads to increased brain levels of the corresponding N-acylethanolamines in piglets, Di Marzo, V., Innis, S., Cavaliere, P., Bisogno, T., Crozier, G., Berger, A., 2001, 10.1073/pnas.101119098

Endocannabinoids Part II: Pathological CNS conditions involving the endocannabinoid system and their possible treatment with endocannabinoid-based drugs, Petrocellis, L.D., Bisogno, T., Di Marzo, V., 2001, 10.1517/14728222.5.3.349

Endovanilloid control of pain modulation by the rostroventromedial medulla in an animal model of diabetic neuropathy, Di Marzo, V., Morgado, C., Tavares, I., Piscitelli, F., Charrua, A., Martins, D., Silva, M., Neuropharmacology, 2016, 10.1016/j.neuropharm.2016.03.007

Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo: Pro-apoptotic effects and underlying mechanisms, Di Marzo, V., Orlando, P., Cristino, L., Stott, C.G., Verde, R., Iappelli, M., Schiano Moriello, A., Ligresti, A., De Petrocellis, L., 2013, 10.1111/j.1476-5381.2012.02027.x

The developmentally regulated avian Ch21 lipocalin is an extracellular fatty acid-binding protein, Cancedda, R., Cermelli, S., Carlevaro, M., Bet, P., Marzo, V.D., Gentili, C., Malpeli, M., Cancedda, F.D., Journal of Biological Chemistry, 1996, 10.1074/jbc.271.33.20163

Prostaglandin F-1,15-lactone fatty acyl esters: a prostaglandin lactone pathway branch developed during the reproduction and early larval stages of a marine mollusc, Cimino, G., Mollo, E., Vardaro, R.R., Minardi, C., Di Marzo, V., 1992, 10.1016/0305-0491(92)90164-M

Dietary fatty acid intake and gut microbiota determine circulating endocannabinoidome signaling beyond the effect of body fat, Veilleux, A., Di Marzo, V., Flamand, N., Raymond, F., Lamarche, B., Martin, C., Perron, J., Parent, L., Rochefort, G., Lacroix, S., Castonguay-Paradis, S., Scientific Reports, 2020, 10.1038/s41598-020-72861-3

Acute resistance exercise induces antinociception by activation of the endocannabinoid system in rats, Perez, A., Di Marzo, V., Duarte, I., Piscitelli, F., Parrella, C., Cruz, J., De Paula, A.M., Aguiar, D., Da Silva, J.F.P., Romero, T., Galdino, G., 2014, 10.1213/ANE.0000000000000340

Endocannabinoid overactivity and abdominal obesity, Despres, J.-P., Di Marzo, V., Abdominal Obesity and the Endocannabinoid System: From Basic Aspects to Clinical Management of Related Cardiometabolic Risk, 2008

Pharmacological enhancement of the endocannabinoid system in the nucleus accumbens shell stimulates food intake and increases c-Fos expression in the hypothalamus, Prospéro-García, O., Di Marzo, V., Navarro, L., Petrosino, S., Cisneros, M., Rueda-Orozco, P.E., Matias, I., Soria-Gómez, E., 2007, 10.1038/sj.bjp.0707313

Hypolocomotor effects in rats of capsaicin and two long chain capsaicin homologues, Fernandez-Ruiz, J.J., Davis, J.B., Milone, A., De Petrocellis, L., Bisogno, T., Lastres-Becker, I., Di Marzo, V., 2001, 10.1016/S0014-2999(01)01012-3

Oleoyl glycine: interference with the aversive effects of acute naloxone-precipitated MWD, but not morphine reward, in male Sprague–Dawley rats, Linda A. Parker, Vincenzo Di Marzo, Raphael Mechoulam, Aron H. Lichtman, Madeleine Sheppard-Perkins, Ashlyn E. Humphrey, Erin M. Rock, Cheryl L. Limebeer, Reem Smoum, Fabiana Piscitelli, Kiri L. Wills, Gavin N. Petrie, Psychopharmacology, 2019, 10.1007/s00213-019-05237-9

Endocannabinoid chemical biology: a tool for the development of novel therapies, Di Marzo, V., Ligresti, A., Petrosino, S., 2009, 10.1016/j.cbpa.2009.04.616

Effects of intra-ventrolateral periaqueductal grey palmitoylethanolamide on thermoceptive threshold and rostral ventromedial medulla cell activity, Maione, S., Di Marzo, V., Rossi, F., Calignano, A., D'Agostino, G., Marabese, I., Russo, R., Palazzo, E., Cristino, L., Guida, F., Luongo, L., De Novellis, V., 2012, 10.1016/j.ejphar.2011.11.034

Two novel classes of neuroactive fatty acid amides are substrates for mouse neuroblastoma 'anandamide amidohydrolase', Di Marzo, V., Marino, G., Di Luccia, A., De Petrocellis, L., Bisogno, T., Maurelli, S., 1995, 10.1016/0014-5793(95)01311-3

Alteration of the endocannabinoid system in mouse brain during prion disease, Chabry, J., Di Marzo, V., Zsürger, N., Ménard, B., Petrosino, S., 2011, 10.1016/j.neuroscience.2010.12.046

Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease, Izzo, A.A., Di Marzo, V., Pagano, E., Battista, G., Orlando, P., Coppola, D., Maiello, F., Capasso, R., Romano, B., Fasolino, I., Borrelli, F., 2013, 10.1016/j.bcp.2013.01.017

Mathematical modeling of fluid dynamics in in vitro gut fermentation systems: A new tool to improve the interpretation of microbial metabolism, Yves Desjardins, Elsa Rousseau, Denis Roy, Vincenzo Di Marzo, Cristoforo Silvestri, Benjamin Gosselin‐Cliche, Charlène Roussel, Joseph Lupien‐Meilleur, Jacob Lessard‐Lord, The FASEB Journal, 2024, 10.1096/fj.202301739RR

Endocannabinoids: An appetite for fat, Di Marzo, V., 2011, 10.1073/pnas.1109567108

The analgesic effect of N-arachidonoyl-serotonin, a FAAH inhibitor and TRPV1 receptor antagonist, associated with changes in rostral ventromedial medulla and locus coeruleus cell activity in rats, Maione, S., Di Marzo, V., Starowicz, K., Marabese, I., Cristino, L., Migliozzi, A., Luongo, L., Guida, F., Petrosino, S., De Petrocellis, L., Rossi, F., Palazzo, E., de Novellis, V., 2008, 10.1016/j.neuropharm.2008.06.023

Alterations in the Endocannabinoid System as a Link Between Unbalanced Energy Homeostasis, Neuroinflammation, and Neurological and Neuropsychiatric Disorders, Di Marzo, V., Bisogno, T., Metabolic Syndrome and Neurological Disorders, 2013, 10.1002/9781118395318.ch12

Effect of docosahexaenoic acid (DHA) at the enteric level in a synucleinopathy mouse model, Soulet, D., Calon, F., Flamand, N., Di Marzo, V., Tremblay, C., Guyaz, C., Côté, M., Dahhani, F., Coulombe, K., Lamontagne‐proulx, J., Nutrients, 2021, 10.3390/nu13124218

Distinct Temporal Fingerprint for Cyclic Adenosine Monophosphate (cAMP) Signaling of Indole-2-carboxamides as Allosteric Modulators of the Cannabinoid Receptors, Glass, M., Silvestri, R., Di Marzo, V., Connor, M., Cawston, E.E., Journal of Medicinal Chemistry, 2015, 10.1021/acs.jmedchem.5b00579

Cannabinoid properties of methylfluorophosphonate analogs, Razdan, R.K., Mahadevan, A., Dasse, O., Di Marzo, V., Deutsch, D.G., Winckler, R., Jefferson, R., Patrick, G., Beletskaya, I., Martin, B.R., 2000

Presynaptic facilitation of glutamatergic synapses to dopaminergic neurons of the rat substantia nigra by endogenous stimulation of vanilloid receptors, Mercuri, N.B., Bernardi, G., Maccarrone, M., Matias, I., Berretta, N., Di Marzo, V., Marinelli, S., 2003

TRPA1 channels as targets for resveratrol and related stilbenoids, De Petrocellis, L., Di Marzo, V., Morera, E., Moriello, A.S., Ortar, G., Nalli, M., Bioorganic and Medicinal Chemistry Letters, 2016, 10.1016/j.bmcl.2015.12.065

Taste sensitivity to 6-n-propylthiouracil is associated with endocannabinoid plasma levels in normal-weight individuals, Banni, S., Di Marzo, V., Muroni, P., Vacca, C., Zonza, A., Melis, M., Murru, E., Carta, G., Tomassini Barbarossa, I., 2013, 10.1016/j.nut.2012.09.018

Anandamide-loaded nanoparticles: Preparation and characterization, Molpeceres, J., Di Marzo, V., Torres, A.I., De Petrocellis, L., Ligresti, L.A., Gil, M.E., Hernán, D., Aberturas, M.R., 2011, 10.3109/02652048.2010.546436

Treatment with the GPR55 antagonist CID16020046 increases neutrophil activation in mouse atherogenesis, Mach, F., Di Marzo, V., Stergiopulos, N., Fraga-Silva, R.A., Brandt, K.J., Dallegri, F., Liberale, L., Roth, A., Carbone, F., Piscitelli, F., Burger, F., Lenglet, S., Bondarenko, A.I., Montecucco, F., Thrombosis and Haemostasis, 2016, 10.1160/TH16-02-0139

Effect on cancer cell proliferation of palmitoylethanolamide, a fatty acid amide interacting with both the cannabinoid and vanilloid signalling systems, Di Marzo, V., Melck, D., Bifulco, M., Ligresti, A., Bisogno, T., De Petrocellis, L., 2002, 10.1046/j.1472-8206.2002.00094.x

Overlapping Distribution of Orexin and Endocannabinoid Receptors and Their Functional Interaction in the Brain of Adult Zebrafish, Marina Paolucci, Vincenzo di Marzo, Ettore Varricchio, Luigia Cristino, Paolo de Girolamo, Fabiana Piscitelli, Hamidreza Ahmadniaye Motlagh, Omid Safari, Livia D’Angelo, Roberta Imperatore, Frontiers in Neuroanatomy, 2018, 10.3389/fnana.2018.00062

Dual role of neuropeptidergic system in pathology of asthma?, Morris, H.R., Tippins, J.R., Marzo, V.D., Trends in Pharmacological Sciences, 1987, 10.1016/0165-6147(87)90158-1

FAAH-Catalyzed C–C Bond Cleavage of a New Multitarget Analgesic Drug, Gennaro Marino, Vincenzo Di Marzo, David F. Woodward, Pietro Amodeo, Sabatino Maione, Angela Amoresano, Anna Illiano, Francesca Guida, Livio Luongo, Robert W. Carling, Marco Allarà, Jenny W. Wang, Fabiana Piscitelli, Jose L. Martos, Rosa Maria Vitale, Cristoforo Silvestri, Alessia Ligresti, ACS Chemical Neuroscience, 2018, 10.1021/acschemneuro.8b00315

Anandamide produced by Ca²⁺-insensitive enzymes induces excitation in primary sensory neurons, Nagy, I., Buluwela, L., Di Marzo, V., Csernoch, L., White, J.P.M., Brain, S., Yaqoob, M., Kyle, F., Taylor, A.H., Andreou, A.P., Piscitelli, F., Selvarajah, S., Austin, J., Chen, J., Sousa-Valente, J., Marczylo, T.H., Jenes, A., Varga, A., Pflugers Archiv European Journal of Physiology, 2014, 10.1007/s00424-013-1360-7

Validation of a fast and sensitive UPLC-MS/MS quantitative method for N-acyl taurine analysis in biological samples, Cutignano, A., Di Marzo, V., Bindels, L.B., Falascina, G., Journal of Pharmaceutical and Biomedical Analysis, 2023, 10.1016/j.jpba.2023.115252

In vitro and in vivo pharmacological characterization of two novel selective cannabinoid CB₂ receptor inverse agonists, Maione, S., Di Marzo, V., Pasquini, S., Corelli, F., Palazzo, E., Pertwee, R.G., Bolognini, D., Cascio, M.G., Pharmacological Research, 2010, 10.1016/j.phrs.2009.11.011

Cannabinoid receptors are absent in insects, Glass, M., Mercer, A., De Petrocellis, L., Marzo, V.D., McPartland, J., Journal of Comparative Neurology, 2001, 10.1002/cne.1078

The ever-expanding world of the endocannabinoids: A concise introduction, Di Marzo, V., Piscitelli, F., Cannabinoids in Neurologic and Mental Disease, 2015, 10.1016/B978-0-12-417041-4.00024-2

Fish Oil, Cannabidiol and the Gut Microbiota: An Investigation in a Murine Model of Colitis, Borrelli, F., Di Marzo, V., Izzo, A.A., Parisi, O.A., Calignano, A., Cristiano, C., Venneri, T., Lacroix, S., Pagano, E., Silvestri, C., Frontiers in Pharmacology, 2020, 10.3389/fphar.2020.585096

Study of the regulation of the endocannabinoid system in a virus model of multiple sclerosis reveals a therapeutic effect of palmitoylethanolamide, Docagne, F., Di Marzo, V., Guaza, C., Hernangómez, M., Correa, F., Spagnolo, A., Mestre, L., Petrosino, S., Loría, F., 2008, 10.1111/j.1460-9568.2008.06377.x

Assessment of the effects of dietary vitamin d levels on olanzapine-induced metabolic side effects: Focus on the endocannabinoidome-gut microbiome axis, Silvestri, C., Di Marzo, V., Flamand, N., Martin, C., Lacroix, S., Leblanc, N., Shen, M., Iannotti, F.A., Manca, C., Abolghasemi, A., International Journal of Molecular Sciences, 2021, 10.3390/ijms222212361

Endocannabinoids: Endogenous cannabinoid receptor ligands with neuromodulatory action (Trends in Neurosciences (521-528) PII S016622369813831386), De Petrocellis, L., Bisogno, T., Melck, D., Di Marzo, V., 1999, 10.1016/S0166-2236(98)01383-6

The effect of vasoactive intestinal peptide and calcitonin gene-related peptide on peptidoleukotriene release from platelet activating factor stimulated rat lungs and ionophore stimulated guinea pig lungs, Morris, H.R., Tippins, J.R., Di Marzo, V., 1986

Three of a kind: Control of the expression of liver-expressed antimicrobial peptide 2 (leap2) by the endocannabinoidome and the gut microbiome, Di Marzo, V., Silvestri, C., Cani, P.D., Flamand, N., Veilleux, A., Iannotti, F.A., Allam-Ndoul, B., Pechereau, F., Nallabelli, N., Suriano, F., Manca, C., Shen, M., Molecules, 2022, 10.3390/molecules27010001

Neurobehavioral activity in mice of N-vanillyl-arachidonyl-amide, Martin, B.R., Razdan, R.K., Szallasi, A., Tao, Q., Patrick, G., Melck, D., Bisogno, T., Breivogel, C., Di Marzo, V., 2000, 10.1016/S0014-2999(00)00687-7

The endocannabinoid system in leptin-driven changes of orexinergic signaling under physiological and pathological conditions, Di Marzo, V., Palomba, L., Imperatore, R., Cristino, L., Endocannabinoids and Lipid Mediators in Brain Functions, 2017, 10.1007/978-3-319-57371-7_1

From phytocannabinoids to cannabinoid receptors and endocannabinoids: Pleiotropic physiological and pathological roles through complex pharmacology, Di Marzo, V., De Petrocellis, L., Ligresti, A., Physiological Reviews, 2016, 10.1152/physrev.00002.2016

New approaches and challenges to targeting the endocannabinoid system, Vincenzo Di Marzo, Nature Reviews Drug Discovery, 2018, 10.1038/nrd.2018.115

Bisphenol a induces fatty liver by an endocannabinoid-mediated positive feedback loop, Carnevali, O., Di Marzo, V., Overby, D.R., Radaelli, G., Allara, M., Gioacchini, G., Maradonna, F., Silvestri, C., Martella, A., Endocrinology, 2016, 10.1210/en.2015-1384

Chemical characterisation of oxidative degradation products of Δ⁹-THC, Gavagnin, M., Di Marzo, V., Ligresti, A., Sutton, A., Daniele, A., Castelluccio, F., Carbone, M., Tetrahedron, 2010, 10.1016/j.tet.2010.10.025

Anandamide and decidual remodelling: COX-2 oxidative metabolism as a key regulator, Teixeira, N., Correia-Da-Silva, G., Di Marzo, V., Fonseca, B.M., Piscitelli, F., Almada, M., Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 2015, 10.1016/j.bbalip.2015.08.011

A re-evaluation of 9-HODE activity at TRPV1 channels in comparison with anandamide: Enantioselectivity and effects at other TRP channels and in sensory neurons, Di Marzo, V., Starowicz, K., Cristino, L., Imperatore, R., Schiano Moriello, A., De Petrocellis, L., 2012, 10.1111/j.1476-5381.2012.02122.x

Endocannabinoids generated by Ca²⁺ or by metabotropic glutamate receptors appear to arise from different pools of diacylglycerol lipase, Alger, B.E., di Marzo, V., Bisogno, T., Wang, M., Zhang, L., PLoS ONE, 2011, 10.1371/journal.pone.0016305

The first dual ChE/FAAH inhibitors: New perspectives for Alzheimer's disease?, Di Marzo, V., Ligresti, A., Andrisano, V., Gobbi, S., Belluti, F., Bisi, A., Bartolini, M., Rampa, A., 2012, 10.1021/ml200313p

Acute neuronal injury, excitotoxicity, and the endocannabinoid system, Vliegenthart, J.F.G., Di Marzo, V., Veldink, G.A., Nicolay, K., Bär, P.R., Maccarrone, M., Veldhuis, W.B., Van der Stelt, M., 2002, 10.1385/MN:26:2-3:317

N-Acyldopamines and N-Acylserotonins: From Synthetic Pharmacological Tools to Endogenous Multitarget Mediators, Di Marzo, V., De Petrocellis, L., The Endocannabinoidome: The World of Endocannabinoids and Related Mediators, 2015, 10.1016/B978-0-12-420126-2.00005-5

Orexin-A and endocannabinoids are involved in obesity-associated alteration of hippocampal neurogenesis, plasticity, and episodic memory in mice, Cristino, L., Di Marzo, V., Maione, S., De Leonibus, E., De Girolamo, P., Capasso, R., Piscitelli, F., Iannotta, M., De Risi, M., Iannotti, F.A., Imperatore, R., Fernández-Rilo, A.C., Tunisi, L., Boccella, S., Forte, N., Nature Communications, 2021, 10.1038/s41467-021-26388-4

The role of cyclic AMP in the inhibition of leukotriene biosynthesis by neuropeptides, Morris, H.R., Tippins, J.R., Di Marzo, V., 1989, 10.1016/0014-2999(89)90610-9

Formation of OX-1R/CB₁R heteromeric complexes in embryonic mouse hypothalamic cells: Effect on intracellular calcium, 2-arachidonoyl-glycerol biosynthesis and ERK phosphorylation, Cristino, L., Marzo, V.D., Piscitelli, F., Spiezio, A.D., Morello, G., Palomba, L., Imperatore, R., Pharmacological Research, 2016, 10.1016/j.phrs.2016.07.009

5th EFLM-UEMS European Joint Congress in Laboratory Medicine, , Clinical Chemistry and Laboratory Medicine (CCLM), 2018, 10.1515/cclm-2018-1038

Cannabinoid actions at TRPV channels: Effects on TRPV3 and TRPV4 and their potential relevance to gastrointestinal inflammation, Izzo, A.A., di Marzo, V., Stott, C., Aviello, G., Moriello, A.S., Orlando, P., de Petrocellis, L., 2012, 10.1111/j.1748-1716.2011.02338.x

Polyunsaturated-fatty-acid oxidation in Hydra: Regioselectivity, substratedependent enantioselectivity and possible biological role, Cimino, G., Milone, A., De Petrocellis, L., Gianfrani, C., Di Marzo, V., 1994

Identification and characterization of phytocannabinoids as novel dual PPARα/γ agonists by a computational and in vitro experimental approach, Vincenzo Di Marzo, Rosa Maria Vitale, Pietro Amodeo, Roy Gray, Francesca Balestrieri, Marco Allarà, Alessandra Gentile, Fabio Arturo Iannotti, Tariq Fellous, Enrico D'Aniello, Biochimica et Biophysica Acta (BBA) - General Subjects, 2019, 10.1016/j.bbagen.2019.01.002

Role of endocannabinoids and endovanilloids in Ca²⁺ signalling, Di Marzo, V., De Petrocellis, L., Cell Calcium, 2009, 10.1016/j.ceca.2009.03.003

Acute inhibition of diacylglycerol lipase blocks endocannabinoid-mediated retrograde signalling: Evidence for on-demand biosynthesis of 2-arachidonoylglycerol, Kano, M., Di Marzo, V., Shimizu, T., Sano, Y., Kita, Y., Tanimura, A., Ohno-Shosaku, T., Hashimotodani, Y., 2013, 10.1113/jphysiol.2013.254474

TRPV1 modulators: Synthesis and in vitro evaluation of 1-heteroaryl piperidinecarboxamide and piperazinylurea derivatives, De Petrocellis, L., Di Marzo, V., Schiano-Moriello, A., Onnis, V., Balboni, G., Congiu, C., European Journal of Medicinal Chemistry, 2015, 10.1016/j.ejmech.2015.05.041

Kavalactones and the endocannabinoid system: The plant-derived yangonin is a novel CB ₁ receptor ligand, Di Marzo, V., Ujváry, I., Allarà, M., Villano, R., Ligresti, A., Pharmacological Research, 2012, 10.1016/j.phrs.2012.04.003

Possible endocannabinoid control of colorectal cancer growth, Di Marzo, V., Sorrentini, I., Bifulco, M., Scaglione, G., D'Argenio, G., Cosenza, V., Cascio, M.G., De Petrocellis, L., Matias, I., Bisogno, T., Ligresti, A., 2003, 10.1016/S0016-5085(03)00881-3

Altered dopamine D3 receptor gene expression in MAM model of schizophrenia is reversed by peripubertal cannabidiol treatment, Micale, V., Di Marzo, V., Mechoulam, R., Drago, F., Starcuk, Z., Wotjak, C.T., Bucolo, C., Sulcova, A., Salomone, S., Giurdanella, G., Fedotova, J., Babinska, Z., Piscitelli, F., Pekarik, V., Kratka, L., D'Addario, C., Ruda-Kucerova, J., Iannotti, F.A., Platania, C.B.M., Drazanova, E., Di Marco, R., Di Bartolomeo, M., Stark, T., Biochemical Pharmacology, 2020, 10.1016/j.bcp.2020.114004

Endocannabinoid-dependent disinhibition of orexinergic neurons: Electrophysiological evidence in leptin-knockout obese mice, Giuseppe Busetto, Luigia Cristino, Vincenzo Di Marzo, Morgana Favero, Thorsten Michael Becker, Molecular Metabolism, 2017, 10.1016/j.molmet.2017.04.005

At the tip of an iceberg: Prenatal marijuana and its possible relation to neuropsychiatric outcome in the offspring, Harkany, T., Di Marzo, V., Alpár, A., Biological Psychiatry, 2016, 10.1016/j.biopsych.2015.09.009

Role of 2-Arachidonoyl-Glycerol and CB1 Receptors in Orexin-A-Mediated Prevention of Oxygen–Glucose Deprivation-Induced Neuronal Injury, Vincenzo Di Marzo, Luigia Cristino, Valeria Bruno, Giuseppe Battaglia, Federica Mastroiacovo, Raffaele Capasso, Fabiana Piscitelli, Roberta Imperatore, Andrea Motta, Letizia Palomba, Cells, 2020, 10.3390/cells9061507

Spinal anandamide produces analgesia in neuropathic rats: Possible CB ₁- and TRPV1-mediated mechanisms, Przewlocka, B., Di Marzo, V., Petrosino, S., Piscitelli, F., Osikowicz, M., Makuch, W., Starowicz, K., Neuropharmacology, 2012, 10.1016/j.neuropharm.2011.11.021

Capsaicin-like effects of N-arachidonoyl-dopamine in the isolated guinea pig bronchi and urinary bladder, Di Marzo, V., Geppetti, P., Bifulco, M., Benvenuti, F., Trevisani, M., De Petrocellis, L., Harrison, S., 2003, 10.1016/S0014-2999(03)02114-9

Cannabinomimetic lipid from a marine cyanobacterium, Gerwick, W.H., Di Marzo, V., Ligresti, A., Debonsi, H.M., Pereira, A.R., Gutiérrez, M., 2011, 10.1021/np200610t

Novel sterically hindered cannabinoid CB₁ receptor ligands, Marzo, V.D., Saturnino, C., Bisogno, T., Ramunno, A., Cascio, M.G., Urbani, P., Bioorganic and Medicinal Chemistry, 2008, 10.1016/j.bmc.2008.06.001

Editorial on “Cannabis and cannabinoids: history, practice and socio-economical inferences of a controversial plant”, Marino, G., Di Marzo, V., Rendiconti Lincei, 2021, 10.1007/s12210-021-00975-5

The anandamide membrane transporter. Structureâ€"activity relationships of anandamide and oleoylethanolamine analogs with phenyl rings in the polar head group region, Ortar, G., Nalli, M., Morera, E., Ligresti, A., Di Marzo, V., 2004, 10.1016/j.bmc.2004.07.026

Cisplatin increases brain 2-arachidonoylglycerol (2-AG) and concomitantly reduces intestinal 2-AG and anandamide levels in the least shrew, Di Marzo, V., Valenti, M., Petrosino, S., Trinh, C., McClanahan, B.A., Darmani, N.A., 2005, 10.1016/j.neuropharm.2005.04.007

Exogenous anandamide protects rat brain against acute neuronal injury in vivo, Nicolay, K., Di Marzo, V., Vliegenthart, J.F.G., Veldink, G.A., Bär, P.R., Bisogno, T., Fezza, F., Van Haaften, G.W., Veldhuis, W.B., Van Der Stelt, M., 2001

Adipocyte-specific Nos2 deletion improves insulin resistance and dyslipidemia through brown fat activation in diet-induced obese mice, Marette, A., Laplante, M., Di Marzo, V., Bellmann, K., Sola-Penna, M., Zancan, P., Centano-Baez, C., Rokatoarivelo, V., Lachance, G., Perazza, L.R., Nachbar, R., Samson, N., Vilela, V.R., Molecular Metabolism, 2022, 10.1016/j.molmet.2022.101437

The CB₁ cannabinoid receptor antagonist AM251 attenuates amphetamine-induced behavioural sensitization while causing monoamine changes in nucleus accumbens and hippocampus, Hasenöhrl, R.U., Molleman, A., Di Marzo, V., Thiemann, G., Pharmacology Biochemistry and Behavior, 2008, 10.1016/j.pbb.2008.01.010

3-Ylidenephthalides as a new class of transient receptor potential channel TRPA1 and TRPM8 modulators, De Petrocellis, L., Di Marzo, V., Nalli, M., Morera, E., Schiano Moriello, A., Ortar, G., 2013, 10.1016/j.bmcl.2013.08.039

Reversal of albuminuria by combined AM6545 and perindopril therapy in experimental diabetic nephropathy, G Gruden, G Bruno, L Annaratone, A Makriyannis, VK Vemuri, B Corbetta, V di Marzo, F Piscitelli, R Gambino, R Mastrocola, S Bellini, F Barutta, British Journal of Pharmacology, 2018, 10.1111/bph.14495

Regulation of hypothalamic endocannabinoid levels by neuropeptides and hormones involved in food intake and metabolism: Insulin and melanocortins, Di Marzo, V., Bertolini, A., Pocai, A., Ottani, A., Petrosino, S., Vergoni, A.V., Matias, I., 2008, 10.1016/j.neuropharm.2007.06.011

The endocannabinoid system as a link between homoeostatic and hedonic pathways involved in energy balance regulation, Cristino, L., Ligresti, A., Di Marzo, V., 2009, 10.1038/ijo.2009.67

Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents, Rampa, A., Bisi, A., Mor, M., Rivara, S., Di Marzo, V., Ligresti, A., Andrisano, V., Gobbi, S., Belluti, F., Bartolini, M., Scalvini, L., Montanari, S., Journal of Medicinal Chemistry, 2016, 10.1021/acs.jmedchem.6b00609

Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells, De Petrocellis, L., Vogel, Z., Bifulco, M., Zagoory, O., Bisogno, T., Orlando, P., Melck, D., Di Marzo, V., 2001, 10.1042/0264-6021:3580249

Endocannabinoids as physiological regulators of colonic propulsion in mice, Capasso, F., Di Marzo, V., Mascolo, N., Brown, D.R., HospodarScott, K., Bisogno, T., Cascio, M.G., Izzo, A.A., Pinto, L., 2002, 10.1053/gast.2002.34242

Homologues and isomers of noladin ether, a putative novel endocannabinoid: Interaction with rat cannabinoid CB₁ receptors, Di Marzo, V., Bisogno, T., Daddario, N., Minassi, A., Ligresti, A., Appendino, G., Bioorganic and Medicinal Chemistry Letters, 2003, 10.1016/S0960-894X(02)00839-9

Participants with Normal Weight or with Obesity Show Different Relationships of 6-n-Propylthiouracil (PROP) Taster Status with BMI and Plasma Endocannabinoids, Iole Tomassini Barbarossa, Sebastiano Banni, Vincenzo Di Marzo, Daniela Demurtas, Laura Muredda, Carla A. Piras, Paolo Pintus, Stefano Pintus, Melania Melis, Gianfranca Carta, Scientific Reports, 2017, 10.1038/s41598-017-01562-1

Regulation, function, and dysregulation of endocannabinoids in models of adipose and β-pancreatic cells and in obesity and hyperglycemia, Di Marzo, V., Monteleone, P., Pagotto, U., Maj, M., Roche, R., Pasquali, R., Festy, F., Hoareau, L., Petrosino, S., Cervino, C., De Petrocellis, L., Martiadis, V., Orlando, P., Gonthier, M.-P., Matias, I., 2006, 10.1210/jc.2005-2679

The pharmacology of palmitoylethanolamide and first data on the therapeutic efficacy of some of its new formulations, Vincenzo Di Marzo, Stefania Petrosino, British Journal of Pharmacology, 2016, 10.1111/bph.13580

Novel interactions between second messengers in rat basophilic leukaemia (RBL-1) cells, Di Marzo, V., Morris, H.R., Galadari, S.H.I., 1990

Synthesis of a potential photoactivatable anandamide analog, Durand, T., Marzo, V.D., Cascio, M.G., Balas, L., Bioorganic and Medicinal Chemistry Letters, 2006, 10.1016/j.bmcl.2006.04.059

Changes in endocannabinoid contents in the brain of rats chronically exposed to nicotine, ethanol or cocaine, Ramos, J.A., Di Marzo, V., Fezza, F., Fernández-Ruiz, J., Grazia Cascio, M., González, S., 2002, 10.1016/S0006-8993(02)03344-9

Exposure to Allergen Causes Changes in NTS Neural Activities after Intratracheal Capsaicin Application, in Endocannabinoid Levels and in the Glia Morphology of NTS, Bruno D’Agostino, Sabatino Maione, Francesco Rossi, Vincenzo Di Marzo, Vito de Novellis, Nikol Sullo, Enza Palazzo, Maria Matteis, Stefania Petrosino, Francesca Guida, Livio Luongo, Giuseppe Spaziano, BioMed Research International, 2015, 10.1155/2015/980983

Effects of diisononyl phthalate (DiNP) on the endocannabinoid and reproductive systems of male gilthead sea bream (Sparus aurata) during the spawning season, Oliana Carnevali, Jaume Pérez-Sánchez, Josep Calduch-Giner, Vincenzo Di Marzo, Fabiana Piscitelli, Maria Papadaki, Ioannis Fakriadis, Constantinos C. Mylonas, Isabel Forner-Piquer, Archives of Toxicology, 2019, 10.1007/s00204-018-2378-6

Exercise training and high-fat diet elicit endocannabinoid system modifications in the rat hypothalamus and hippocampus, Heyman, E., Di Marzo, V., Bastide, B., Leclair, E., Cieniewski-Bernard, C., Dupont, E., Leriche, M., Aveta, T., Mazzarella, E., Piscitelli, F., Iannotti, F.A., Aucouturier, J., Gamelin, F.-X., Journal of Physiology and Biochemistry, 2016, 10.1007/s13105-017-0557-1

Impact of omega-6 polyunsaturated fatty acid supplementation and γ-aminobutyric acid on astrogliogenesis through the endocannabinoid system, Di Marzo, V., Verde, R., Piscitelli, F., Shinjyo, N., 2013, 10.1002/jnr.23231

Spontaneous and Naloxone-Precipitated Withdrawal Behaviors From Chronic Opiates are Accompanied by Changes in N-Oleoylglycine and N-Oleoylalanine Levels in the Brain and Ameliorated by Treatment With These Mediators, Parker, L.A., Di Marzo, V., Mechoulam, R., Leri, F., Lichtman, A.H., Nallabelli, N., Boubertakh, B., Lacroix, S., Sullivan, M.T., de Almeida, H., Farag, M., Smoum, R., Rock, E.M., Limebeer, C.L., Silvestri, C., Piscitelli, F., Ayoub, S.M., Frontiers in Pharmacology, 2021, 10.3389/fphar.2021.706703

The endocannabinoid system in metabolic control: a preface, Di Marzo, V., 2009, 10.1016/j.beem.2008.12.005

Endocannabinoid signaling at the periphery: 50 years after THC, Zimmer, A., Sharkey, K.A., Pacher, P., Mechoulam, R., Kunos, G., Konje, J.C., Di Marzo, V., Dey, S.K., Cabral, G.A., Bíró, T., Bab, I., Maccarrone, M., Trends in Pharmacological Sciences, 2015, 10.1016/j.tips.2015.02.008

Occurrence and biosynthesis of 11(R)-hydroxy-eicosatetraenoic acid (11-R-HETE) in the Caribbean soft coral Plexaurella dichotoma, Cimino, G., Mosca, M., Mollo, E., Ventriglia, M., Di Marzo, V., 1996

Adverse effects of Δ⁹-tetrahydrocannabinol on neuronal bioenergetics during postnatal development, Keimpema, E., Harkany, T., Marzo, V.D., Gray, R., Guy, G.W., Kasper, S., Botting, C.H., Shirran, S., Lubec, G., Szodorai, E., Romanov, R., Pyszkowski, J., Calvigioni, D., Hevesi, Z., Beiersdorf, J., JCI Insight, 2020, 10.1172/jci.insight.135418

Elevated endocannabinoid plasma levels are associated with coronary circulatory dysfunction in obesity, Schindler, T.H., MacH, F., Harsch, E., Ratib, O., Golay, A., Seimbille, Y., Steffens, S., Staub, C., Thomas, A., Carballo, S., Montecucco, F., Di Marzo, V., Makoundou, V., Vincenti, G., Pataky, Z., Quercioli, A., 2011, 10.1093/eurheartj/ehr029

Anandamide inhibits nuclear factor-κB activation through a cannabinoid receptor-independent pathway, Muñoz, E., Appendino, G., Di Marzo, V., Calzado, M.A., Sancho, R., 2003, 10.1124/mol.63.2.429

Author Correction: CB1 receptor activation induces intracellular Ca2+ mobilization and 2-arachidonoylglycerol release in rodent spinal cord astrocytes, Miklós Antal, Vincenzo Di Marzo, László Csernoch, Balázs Pál, Krisztina Holló, Fabiana Piscitelli, Áron Kőszeghy, Tamás Oláh, Zoltán Hegyi, Scientific Reports, 2018, 10.1038/s41598-018-30573-9

An introduction to the endocannabinoid system: from the early to the latest concepts, Di Marzo, V., De Petrocellis, L., 2009, 10.1016/j.beem.2008.10.013

Alterations of brain endocannabinoidome signaling in germ-free mice, Di Marzo, V., Silvestri, C., Flamand, N., Martin, C., Boubertakh, B., Shen, M., Manca, C., Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 2020, 10.1016/j.bbalip.2020.158786

The endocannabinoidome as a substrate for noneuphoric phytocannabinoid action and gut microbiome dysfunction in neuropsychiatric disorders, Di Marzo, V., Dialogues in Clinical Neuroscience, 2020, 10.31887/DCNS.2020.22.3/VDIMARZO

Endocannabinoid signalling in the blood of patients with schizophrenia, Di Marzo, V., Fezza, F., Daniele, F., Orlando, P., De Petrocellis, L., De Marchi, N., 2003, 10.1186/1476-511X-2-1

Changes in the endocannabinoid signaling system in CNS structures of TDP-43 transgenic mice: relevance for a neuroprotective therapy in TDP-43-related disorders, Fernández-Ruiz, J., de Lago, E., Di Marzo, V., Ramos, J.A., Verde, R., Piscitelli, F., Espejo-Porras, F., Journal of Neuroimmune Pharmacology, 2015, 10.1007/s11481-015-9602-4

Olive oil-derived endocannabinoid-like mediators inhibit palatable food-induced reward and obesity, Cristino, L., Di Marzo, V., Mollica, M.P., Piscitelli, F., Silvestri, C., Giorgini, G., Khalilzadehsabet, T., Salviati, E., De Leonibus, E., Villano, R., Lauritano, A., Marfella, B., Roussel, C., Forte, N., Communications Biology, 2023, 10.1038/s42003-023-05295-y

The activation of the cannabinoid receptor type 2 reduces neutrophilic protease-mediated vulnerability in atherosclerotic plaques, Mach, F., Steffens, S., Stergiopulos, N., Santos, R.A.S., Roux-Lombard, P., Dallegri, F., Palombo, D., Viviani, G.L., Pende, A., Gayet-Ageron, A., Braunersreuther, V., Spinella, G., Pane, B., Burger, F., Kuzmanovic, K., Pilet, L., Galan, K., Pelli, G., Bertolotto, M., Quintao, S., Piscitelli, F., Pagano, S., Lenglet, S., Capettini, L., Vuilleumier, N., Da Silva, R.F., Di Marzo, V., Montecucco, F., 2012, 10.1093/eurheartj/ehr449

Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: Stimulation of eating by 2-arachidonoyl glycerol, Di Marzo, V., Fezza, F., Williams, C.M., Kirkham, T.C., 2002

The palmitoylethanolamide and oleamide enigmas: Are these two fatty acid amides cannabimimetic?, Di Marzo, V., Lambert, D.M., 1999

Crosstalk between the transcriptional regulation of dopamine D2 and cannabinoid CB1 receptors in schizophrenia: Analyses in patients and in perinatal Δ9-tetrahydrocannabinol-exposed rats, Micale, V., D'Addario, C., Dell'Osso, B., Vismara, M., Di Marzo, V., Wotjak, C.T., Drago, F., Maccarrone, M., Mechoulam, R., Arosio, B., Salomone, S., Pekarik, V., Laudani, S., Piscitelli, F., Ruda-Kucerova, J., Kuchar, M., Iannotti, F.A., Maurel, O.M., Stark, T., Di Bartolomeo, M., Pharmacological Research, 2021, 10.1016/j.phrs.2020.105357

Brain and peripheral anandamide amidohydrolase and its inhibition by synthetic arachidonate analogues, Di Marzo, V., 1997

Life-long epigenetic programming of cortical architecture by maternal ‘Western’ diet during pregnancy, Harkany, T., Keimpema, E., Bock, C., McBain, C.J., Mackie, K., Di Marzo, V., Kasper, S., Yanagawa, Y., Szabó, G., Máté, Z., Piscitelli, F., Poullet, P., Botting, C.H., Fuszard, M.A., Shirran, S.L., Fife-Gernedl, V., Halbritter, F., Farlik, M., Calvigioni, D., Cinquina, V., Molecular Psychiatry, 2020, 10.1038/s41380-019-0580-4

An orally active Cannabis extract with high content in cannabidiol attenuates chemically-induced intestinal inflammation and hypermotility in the mouse, Borrelli, F., Di Marzo, V., Izzo, A.A., Lauritano, A., Finizio, S., Parisi, O.A., Romano, B., Piscitelli, F., Capasso, R., Pagano, E., Frontiers in Pharmacology, 2016, 10.3389/fphar.2016.00341

Techniques for the Cellular and Subcellular Localization of Endocannabinoid Receptors and Enzymes in the Mammalian Brain, Vincenzo Di Marzo, Roberta Imperatore, Luigia Cristino, Methods in Enzymology, 2017, 10.1016/bs.mie.2017.05.003

Synthesis and biological evaluation of new potential inhibitors of N-acylethanolamine hydrolyzing acid amidase, Marzo, V.D., Bisogno, T., Martino, G.D., Palladino, C., Ligresti, A., Petrosino, S., Saturnino, C., Bioorganic and Medicinal Chemistry Letters, 2010, 10.1016/j.bmcl.2009.11.134

Biochemistry of the endogenous ligands of cannabinoid receptors, Deutsch, D.G., Di Marzo, V., 1998, 10.1006/nbdi.1998.0214

Structure-activity relationships of the ultrapotent vanilloid resiniferatoxin (RTX): The side chain benzylic methylene, Marzo, V.D., De Petrocellis, L., Minassi, A., Ech-Chahad, A., Appendino, G., Bioorganic and Medicinal Chemistry Letters, 2010, 10.1016/j.bmcl.2009.11.035

Dopamides, vanillylamides, ethanolamides, and arachidonic acid amides of anti-inflammatory and analgesic drug substances as TRPV1 ligands, Imming, P., Di Marzo, V., De Petrocellis, L., Watzer, B., Sinning, C., 2008, 10.1002/cmdc.200800271

Development of a potent inhibitor of 2-arachidonoylglycerol hydrolysis with antinociceptive activity in vivo, Di Marzo, V., Maione, S., Nalli, M., Palazzo, E., Morera, E., Petrosino, S., Ortar, G., Bisogno, T., 2009, 10.1016/j.bbalip.2008.10.007

Structure-activity relationships of thiazole and benzothiazole derivatives as selective cannabinoid CB2 agonists with in vivo anti-inflammatory properties, Ashraf H. Abadi, Noha A. Osman, Vincenzo Di Marzo, Ali Mokhtar Mahmoud, Alessandro Rabbito, Alessia Ligresti, Aya E. Ghonim, European Journal of Medicinal Chemistry, 2019, 10.1016/j.ejmech.2019.07.002

Peripheral endocannabinoid dysregulation in obesity: Relation to intestinal motility and energy processing induced by food deprivation and re-feeding, Di Marzo, V., Petrosino, S., Borrelli, F., Romano, B., Aviello, G., Capasso, R., Piscitelli, F., Izzo, A.A., 2009, 10.1111/j.1476-5381.2009.00183.x

CB₁ cannabinoid receptors couple to focal adhesion kinase to control insulin release, Dobrzyn, A., Harkany, T., Redowicz, M.J., Di Marzo, V., Mackie, K., Janikiewicz, J., Silvestri, C., Keimpema, E., Jazurek, M., Malenczyk, K., Journal of Biological Chemistry, 2013, 10.1074/jbc.M113.478354

The 1,2,3-triazole ring as a peptido- and olefinomimetic element: Discovery of click yanilloids and cannabinoids, Di Marzo, V., De Petrocellis, L., Cascio, M.G., Minassi, A., Bacchiega, S., Appendino, G., 2007, 10.1002/anie.200703590

New potent and selective inhibitors of anandamide reuptake with antispastic activity in a mouse model of multiple sclerosis, Di Marzo, V., Razdan, R.K., Martin, B.R., Baker, D., Wiley, J.L., Visintin, C., Mahadevan, A., Saha, B., De Petrocellis, L., Beletskaya, I., Kulasegram, S., Pryce, G., Cascio, M.G., Ligresti, A., 2006, 10.1038/sj.bjp.0706418

Behavioral and molecular changes elicited by acute administration of SR141716 to Δ⁹-tetrahydrocannabinol-tolerant rats: An experimental model of cannabinoid abstinence, Ramos, J.A., Ambrosio, E., Cascio, M.G., Nicanor, C., Arévalo, C., Hernández, M., Di Marzo, V., Fernández-Ruiz, J., González, S., Drug and Alcohol Dependence, 2004, 10.1016/j.drugalcdep.2003.12.011

Lipids as regulators of the activity of transient receptor potential type V1 (TRPV1) channels, Di Marzo, V., De Petrocellis, L., 2005, 10.1016/j.lfs.2005.05.021

The endocannabinoidome mediator N-oleoylglycine is a novel protective agent against 1-methyl-4-phenyl-pyridinium-induced neurotoxicity, Piscitelli, F., Di Marzo, V., Iannotti, F.A., Moriello, C., Kalkan, H., Verde, R., Cipollone, I., Lauritano, A., Frontiers in Aging Neuroscience, 2022, 10.3389/fnagi.2022.926634

Cannabinoids in the Treatment of Neurological Disorders, Di Marzo, V., Whalley, B.J., Devinsky, O., Neurotherapeutics, 2015, 10.1007/s13311-015-0388-0

Early low-fat diet enriched with linolenic acid reduces liver endocannabinoid tone and improves late glycemic control after a high-fat diet challenge in mice, Degrace, P., Di Marzo, V., Silvestri, C., Bellenger, J., Muller, T., Gresti, J., Borrino, S., Iannotti, F.A., Troy-Fioramonti, S., Piscitelli, F., Demizieux, L., Diabetes, 2016, 10.2337/db15-1279

The Endocannabinoid System and its Modulation by Phytocannabinoids, Piscitelli, F., Di Marzo, V., Neurotherapeutics, 2015, 10.1007/s13311-015-0374-6

N-acyl-dopamines: Novel synthetic CB₁ cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo, Di Marzo, V., De Petrocellis, L., Bezuglov, V.V., Gretskaya, N.M., Bobrov, M.Yu., Melck, D., Bisogno, T., Biochemical Journal, 2000, 10.1042/0264-6021:3510817

Structure-activity relationship of human calcitonin-gene-related peptide, MacIntyre, I., Morris, H.R., Chambers, T.J., Moonga, B.S., Di Marzo, V., Tippins, J.R., Brain, S.D., Zaidi, M., 1990

Endocannabinoids: New targets for drug development, De Petrocellis, L., Bisogno, T., Di Marzo, V., 2000

α₂-Adrenoceptor agonist induces peripheral antinociception via the endocannabinoid system, Duarte, I.D.G., Di Marzo, V., Piscitelli, F., Parrella, C., Miranda e Castor, M.G., Romero, T.R.L., Pharmacological Reports, 2020, 10.1007/s43440-019-00053-6

Evolutionary origins of the endocannabinoid system, Glass, M., Di Marzo, V., Matias, I., McPartland, J.M., 2006, 10.1016/j.gene.2005.11.004

Circulating endocannabinoids and the polymorphism 385C>A in fatty acid amide hydrolase (FAAH) gene may identify the obesity phenotype related to cardiometabolic risk: A study conducted in a Brazilian population of complex interethnic admixture, Francischetti, E.A., Di Marzo, V., Silvestri, C., Aveta, T., Mangia, R.F., Celoria, B.M.J., Pimentel, M.M.G., Genelhu, V., De Moraes Martins, C.J., PLoS ONE, 2015, 10.1371/journal.pone.0142728

Correction to: 2-Pentadecyl-2-oxazoline ameliorates memory impairment and depression-like behaviour in neuropathic mice: possible role of adrenergic alpha2- and H3 histamine autoreceptors (Molecular Brain, (2021), 14, 1, (28), 10.1186/s13041-020-00724-z), Luongo, L., Maione, S., Di Marzo, V., Calignano, A., Palazzo, E., Paino, S., de Novellis, V., Belardo, C., Marabese, I., Amodeo, P., Vitale, R.M., Cristiano, C., Ricciardi, F., Infantino, R., Iannotti, F.A., Iannotta, M., Guida, F., Boccella, S., Molecular Brain, 2021, 10.1186/s13041-021-00772-z

Taste-guided identification of high potency TRPA1 agonists from Perilla frutescens, Petrocellis, L.D., Marzo, V.D., Moriello, A.S., Morini, G., Scaglioni, L., Caimi, S., Borgonovo, G., Bassoli, A., Bioorganic and Medicinal Chemistry, 2009, 10.1016/j.bmc.2008.12.057

Arachidonoylserotonin and other novel inhibitors of fatty acid amide hydrolase, Marzo, V.D., Gerwick, W.H., Sitachitta, N., Bezuglov, V.V., Gretskaya, N.M., Bobrov, M.Y., De Petrocellis, L., Melck, D., Bisogno, T., Biochemical and Biophysical Research Communications, 1998, 10.1006/bbrc.1998.8874

Novel mechanisms in obesity, type 2 diabetes and accompanying inflammation: Focus on lipid signaling, Di Marzo, V., 2010, 10.1016/j.ddmec.2011.01.001

Orexin-A and endocannabinoid activation of the descending antinociceptive pathway underlies altered pain perception in leptin signaling deficiency, Di Marzo, V., Maione, S., Busetto, G., Piscitelli, F., Morello, G., Becker, T., Boccella, S., Imperatore, R., Luongo, L., Cristino, L., Neuropsychopharmacology, 2016, 10.1038/npp.2015.173

Full Inhibition of Spinal FAAH Leads to TRPV1-Mediated Analgesic Effects in Neuropathic Rats and Possible Lipoxygenase-Mediated Remodeling of Anandamide Metabolism, Di Marzo, V., Przewlocka, B., Cristino, L., De Petrocellis, L., Petrosino, S., Zychowska, M., Slezak, M., Malek, N., Korostynski, M., Makuch, W., Starowicz, K., 2013, 10.1371/journal.pone.0060040

Cannabidiol, a safe and non-psychotropic ingredient of the marijuana plant Cannabis sativa, is protective in a murine model of colitis, Izzo, A.A., Di Marzo, V., Capasso, F., Petrosino, S., Guadagno, F., Maiello, F., Capasso, R., Orlando, P., Aviello, G., Romano, B., Borrelli, F., 2009, 10.1007/s00109-009-0512-x

Mooreamide A: A cannabinomimetic lipid from the marine cyanobacterium Moorea bouillonii, Gerwick, W.H., Di Marzo, V., Allara', M., Matainaho, T., Mevers, E., 2014, 10.1007/s11745-014-3949-9

Endocannabinoid modulation in the olfactory epithelium, Schild, D., Manzini, I., Di Marzo, V., Piscitelli, F., Czesnik, D., Breunig, E., 2010, 10.1007/978-3-642-14426-4_11

Exploiting Nanotechnologies and TRPV1 Channels to Investigate the Putative Anandamide Membrane Transporter, di Marzo, V., Molpeceres, J., Torres, A.-I., Gil, M.E., Finizio, A., Moriello, A.S., Cristino, L., Aberturas, R., de la Ossa, D.H.P., de Petrocellis, L., Ligresti, A., 2010, 10.1371/journal.pone.0010239

Biosynthesis and degradation of bioactive fatty acid amides in human breast cancer and rat pheochromocytoma cells - Implications for cell proliferation and differentiation, Di Marzo, V., Yamamoto, S., De Petrocellis, L., Ueda, N., Melck, D., Katayama, K., Bisogno, T., 1998, 10.1046/j.1432-1327.1998.2540634.x

Endovanilloids: Putative endogenous ligands of transient receptor potential vanilloid 1 channels, Di Marzo, V., Van Der Stelt, M., 2004, 10.1111/j.1432-1033.2004.04081.x

The endocannabinoid system and pivotal role of the CB₂ receptor in mouse spermatogenesis, Di Marzo, V., De Petrocellis, L., Bisogno, T., Geremia, R., Petrosino, S., Lolicato, F., Di Siena, S., Orlando, P., Grimaldi, P., Proceedings of the National Academy of Sciences of the United States of America, 2009, 10.1073/pnas.0812789106

First "hybrid" ligands of vanilloid TRPV1 and cannabinoid CB ₂ receptors and non-polyunsaturated fatty acid-derived CB ₂-selective ligands, Di Marzo, V., De Petrocellis, L., Pertwee, R., Ross, R., Thomas, A., Minassi, A., Moriello, A.S., Bacchiega, S., Cascio, M.G., Appendino, G., FEBS Letters, 2006, 10.1016/j.febslet.2005.12.069

Oxyhomologues of anandamide and related endolipids: Chemoselective synthesis and biological activity, Di Marzo, V., De Petrocellis, L., Cascio, M.G., Moriello, A.S., Berton, L., Minassi, A., Appendino, G., 2006, 10.1021/jm051240y

New perspectives on enigmatic vanilloid receptors, Di Marzo, V., Szallasi, A., 2000, 10.1016/S0166-2236(00)01630-1

Involvement of the Endocannabinoid System in the Control of Pain and Obesity by Exercise in Rodents: A Systematic Review, Galdino, G., Di Marzo, V., Rodríguez, J., Malta, I., Moraes, T., Elisei, L., Cannabis and Cannabinoid Research, 2023, 10.1089/can.2022.0291

Play an ADAGIO with a STRADIVARIUS: The right patient for CB1 receptor antagonists?, Di Marzo, V., 2008, 10.1038/ncpcardio1319

Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain, Doherty, P., Di Marzo, V., Hobbs, C., Gangadbaran, U., Williams, E.-J., Paul, P., Schiano-Moriello, A., Matias, I., Ligresti, A., Cascio, M.G., Minassi, A., Williams, G., Howell, F., Bisogno, T., 2003, 10.1083/jcb.200305129

Neuropeptides and leukotriene biosynthesis: The effect of calcitonin, peptide histidine valine-42, helodermin, neuropeptide Y and galanin, Morris, H.R., Galadari, S.H.I., Tippins, J.R., Di Marzo, V., 1988, 10.1016/0143-4179(88)90071-6

Phytocannabinoids promote viability and functional adipogenesis of bone marrow-derived mesenchymal stem cells through different molecular targets, Iannotti, F.A., Di Marzo, V., Maione, S., Petrosino, S., Boccella, S., Carannante, B., Kalkan, H., De Maio, F., Fellous, T., Biochemical Pharmacology, 2020, 10.1016/j.bcp.2020.113859

Preface, Di Marzo, V., Després, J.-P., Abdominal Obesity and the Endocannabinoid System: From Basic Aspects to Clinical Management of Related Cardiometabolic Risk, 2008

Oxidative metabolism of lipoamino acids and vanilloids by lipoxygenases and cyclooxygenases, Marnett, L.J., Marzo, V.D., Al-Mestarihi, A.H., Ball, H.L., Vila, A., Turman, M.V., Prusakiewicz, J.J., Archives of Biochemistry and Biophysics, 2007, 10.1016/j.abb.2007.04.007

The synthesis, release and action of leukotrienes in the isolated, unstimulated, buffer-perfused rat heart, Maisey, M.N., Morris, H.R., Tippins, J.R., Di Marzo, V., Mashiter, G.D., Garlick, P.B., 1989, 10.1016/0022-2828(89)90688-3

Cannabidiol improves vocal learning-dependent recovery from, and reduces magnitude of deficits following, damage to a cortical-like brain region in a songbird pre-clinical animal model, Ken Soderstrom, Vincenzo Di Marzo, James Brodie, Marie Woolley-Roberts, Julien C. Dodu, Ali Alalawi, Neuropharmacology, 2019, 10.1016/j.neuropharm.2019.107716

Palmitoylethanolamide, endocannabinoids and related cannabimimetic compounds in protection against tissue inflammation and pain: Potential use in companion animals, Di Marzo, V., Miolo, A., Barbero, R., Re, G., 2007, 10.1016/j.tvjl.2005.10.003

Enhancement of anandamide formation in the limbic forebrain and reduction of endocannabinoid contents in the striatum of Δ⁹- tetrahydrocannabinol-tolerant rats, Fernández-Ruiz, J.J., Ramos, J.A., Cebeira, M., Romero, J., Cavaliere, P., González, S., Bisogno, T., Berrendero, F., Di Marzo, V., Journal of Neurochemistry, 2000, 10.1046/j.1471-4159.2000.0741627.x

Editorial, Di Marzo, V., 2014, 10.2174/157488980901140428100532

Possible involvement of endocannabinoids in the increase of morphine consumption in maternally deprived rat, Daugé, V., Di Marzo, V., Giros, B., Piscitelli, F., Naudon, L., 2013, 10.1016/j.neuropharm.2012.10.008

Beneficial effects of akkermansia muciniphila are not associated with major changes in the circulating endocannabinoidome but linked to higher mono-palmitoyl-glycerol levels as new pparα agonists, Cani, P.D., Marzo, V.D., de Vos, W.M., Delzenne, N.M., Hermans, M.P., Loumaye, A., Thissen, J.-P., Maiter, D., Pelicaen, R., Everard, A., Druart, C., Flamand, N., Silvestri, C., Iannotti, F.A., Vitale, R.M., Depommier, C., Cells, 2021, 10.3390/cells10010185

Rimonabant in rats with a metabolic syndrome: Good news after the depression, Szallasi, A., Di Marzo, V., 2008, 10.1038/bjp.2008.170

CB2-selective cannabinoid receptor ligands: Synthesis, pharmacological evaluation, and molecular modeling investigation of 1,8-naphthyridin-2(1 H)-one-3-carboxamides, Manera, C., Reggio, P.H., Abood, M.E., Di Marzo, V., Macchia, M., Sharir, H., Saccomanni, G., Minutolo, F., Ligresti, A., Lawrence, L., Allarà, M., Ehrmann, B.M., Bertini, S., Shore, D.M., Hurst, D.P., Lucchesi, V., Journal of Medicinal Chemistry, 2014, 10.1021/jm500807e

Arachidonic acid and eicosanoids in Hydra: Possible endogenous signals involved in chemoreception and modulation of the feeding behaviour, Di Marzo, V., Minei, R., De Petrocellis, L., Pierobon, P., Advances in Experimental Medicine and Biology, 1997, 10.1007/978-1-4899-1810-9_78

Prostaglandin Ethanolamides (Prostamides): In Vitro Pharmacology and Metabolism, Woodward, D.F., Di Marzo, V., Burk, R.M., Kedzie, K.M., Nieves, A.L., Liang, Y., Li, C., Protzman, C.E., Shi, L., Krauss, A.H.-P., Fezza, F., Ligresti, A., Bisogno, T., De Petrocellis, L., Chen, J., Matias, I., 2004, 10.1124/jpet.103.061705

A Designer Diet Induces Thermogenic Adipocytes via Raptor and Prolongs Healthy Lifespan, Enzo Nisoli, Alessandra Valerio, Sheila Collins, Roberto Coppari, Gianluigi Condorelli, Ilaria Decimo, Saverio Cinti, Michele O. Carruba, Claudio Luchinat, Vincenzo Di Marzo, Francesco Bifari, Kieran Tuohy, Matthias U. Scholz, Lisa Rizzetto, Leonardo Tenori, Luisa Ponzoni, Ryan P. Ceddia, Dianxin Liu, Ilenia Severi, Annachiara Pino, Carolina Greco, Laura Tedesco, Franck Bontems, Rafael Maciel Ioris, Emiliano Manzo, Adele Cutignano, Fabiana Piscitelli, Veronica Ghini, Pierluigi Carullo, Fabio Rossi, Chiara Ruocco, Maurizio Ragni, SSRN Electronic Journal, 1911, 10.2139/ssrn.3435269

Endocannabinoid pathways and their role in multiple sclerosis-related muscular dysfunction, Di Marzo, V., 2011, 10.1586/ern.11.26

CB1 receptor activation induces intracellular Ca2+ mobilization and 2-arachidonoylglycerol release in rodent spinal cord astrocytes, Miklós Antal, Vincenzo Di Marzo, László Csernoch, Balázs Pál, Krisztina Holló, Fabiana Piscitelli, Áron Kőszeghy, Tamás Oláh, Zoltán Hegyi, Scientific Reports, 2018, 10.1038/s41598-018-28763-6

Biosynthesis, uptake, and degradation of anandamide and palmitoylethanolamide in leukocytes, Di Marzo, V., De Petrocellis, L., Melck, D., Maurelli, S., Bisogno, T., 1997, 10.1074/jbc.272.6.3315

Low fatty acid amide hydrolase and high anandamide levels are associated with failure to achieve an ongoing pregnancy after IVF and embryo transfer, Finazzi-Agrò, A., Di Marzo, V., Manna, C., Fezza, F., Lazzarin, N., Valensise, H., Bisogno, T., Maccarrone, M., 2002

Prefrontal cortex stimulation induces 2-arachidonoyl-glycerol-mediated suppression of excitation in dopamine neurons, Pistis, M., Gessa, G.L., Di Marzo, V., Marsicano, G., Lutz, B., Pillolla, G., Muntoni, A.L., Perra, S., Melis, M., 2004, 10.1523/JNEUROSCI.3502-04.2004

Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning, Harkany, T., Galve-Roperh, I., Lu, H.-C., Guzmán, M., Lutz, B., Mackie, K., Guillemot, F., Hurd, Y.L., Di Marzo, V., Marsicano, G., Menory, K., Nguyen, L., Rosado, C.J.B., Barabás, K., Keimpema, E., Aguado, T., Mulder, J., 2008, 10.1073/pnas.0803545105

Linking the Endocannabinoidome with Specific Metabolic Parameters in an Overweight and Insulin-Resistant Population: From Multivariate Exploratory Analysis to Univariate Analysis and Construction of Predictive Models, Patrice D. Cani, Vincenzo Di Marzo, Nathalie M. Delzenne, Amandine Everard, Michel P. Hermans, Audrey Loumaye, Jean-Paul Thissen, Dominique Maiter, Rudy Pelicaen, Nicolas Flamand, Clara Depommier, Cells, 2021, 10.3390/cells10010071

Goods and Bads of the Endocannabinoid System as a Therapeutic Target: Lessons Learned after 30 Years, van der Stelt, M., Ueda, N., Piomelli, D., Makriyannis, A., Hua, T., Howlett, A.C., Grether, U., Gertsch, J., Marzo, V.D., Maccarrone, M., Pharmacological Reviews, 2023, 10.1124/pharmrev.122.000600

Selection of alternative G_i-mediated signaling pathways at the dopamine D₂ receptor by protein kinase C, Piomelli, D., Schwartz, J.-C., Sokoloff, P., Vial, D., Marzo, V.D., Journal of Neuroscience, 1993

Dietary krill oil increases docosahexaenoic acid and reduces 2-arachidonoylglycerol but not N-acylethanolamine levels in the brain of obese Zucker rats, Banni, S., Uda, S., Berge, K., Batetta, B., Collu, M., Bisogno, T., Giordano, E., Cordeddu, L., Ligresti, A., Murru, E., Carta, G., Griinari, M., Di Marzo, V., 2010, 10.1016/j.idairyj.2009.11.015

Endocannabinoids may mediate the ability of (n-3) fatty acids to reduce ectopic fat and inflammatory mediators in obese Zucker rats, Banni, S., Di Marzo, V., Bruheim, I., Collu, M., Uda, S., Bisogno, T., Sanna, F., Giordano, E., Cordeddu, L., Ligresti, A., Murru, E., Carta, G., Griinari, M., Batetta, B., 2009, 10.3945/jn.109.104844

Maternal dietary fat determines metabolic profile and the magnitude of endocannabinoid inhibition of the stress response in neonatal rat offspring, Walker, C.-D., Di Marzo, V., Cunnane, S.C., Grajzer, M., Tremblay-Mercier, J., Long, H., D'Asti, E., 2010, 10.1210/en.2009-1092

Preface, Wang, J.W., Di Marzo, V., The Endocannabinoidome: The World of Endocannabinoids and Related Mediators, 2014, 10.1016/B978-0-12-420126-2.00016-X

Targeting the endocannabinoid system in cancer therapy: A call for further research, Di Marzo, V., Bifulco, M., 2002, 10.1038/nm0602-547

The endocannabinoid system: Its general strategy of action, tools for its pharmacological manipulation and potential therapeutic exploitation, Di Marzo, V., 2009, 10.1016/j.phrs.2009.02.010

This first 2014 issue of Recent Patents in CNS Drug Discovery covers a range of rather diverse, but not necessarily unrelated topics. Introduction, Marzo, V.D., Recent patents on CNS drug discovery, 2014

Endocannabinoids: Some like it fat (and sweet too), Di Marzo, V., Cristino, L., Matias, I., 2008, 10.1111/j.1365-2826.2008.01678.x

Increased levels of palmitoylethanolamide and other bioactive lipid mediators and enhanced local mast cell proliferation in canine atopic dermatitis, Miragliotta, V., Di Marzo, V., Petrosino, S., Cristino, L., della Valle, M.F., Albanese, F., Campora, L., Abramo, F., 2014, 10.1186/1746-6148-10-21

Pharmacological inhibition of MAGL attenuates experimental colon carcinogenesis, Angelo A. Izzo, Vincenzo Di Marzo, Lorena Buono, Fabiana Piscitelli, Raffaele Capasso, Roberta Imperatore, Gabriella Aviello, Lucia Morbidelli, Martina Monti, Barbara Romano, Pierangelo Orlando, Francesca Borrelli, Ester Pagano, Pharmacological Research, 2017, 10.1016/j.phrs.2017.02.002

Palmitoylethanolamide induces microglia changes associated with increased migration and phagocytic activity: involvement of the CB2 receptor, S. Maione, V. de Novellis, V. Di Marzo, L. Cristino, F. sca Rossi, F. Piscitelli, E. D’Aniello, F. A. Iannotti, R. Imperatore, A. Rizzo, A. Furiano, I. Manzo, G. Bellini, R. Romano, M. E. Giordano, S. Boccella, L. Luongo, F. Guida, Scientific Reports, 2017, 10.1038/s41598-017-00342-1

Circulating endocannabinoids in insulin sensitive vs. Insulin resistant obese postmenopausal women. A MONET group study, Di Marzo, V., Prud'Homme, D., Piscitelli, F., Petrosino, S., Faraj, M., Rabasa-Lhoret, R., Yasari, S., Abdulnour, J., 2014, 10.1002/oby.20498

The inhibition of 2-arachidonoyl-glycerol (2-AG) biosynthesis, rather than enhancing striatal damage, protects striatal neurons from malonate-induced death: A potential role of cyclooxygenase-2-dependent metabolism of 2-AG, Fernández-Ruiz, J., Di Marzo, V., Sagredo, O., Allarà, M., Iannotti, F.A., Piscitelli, F., Bisogno, T., Pazos, M.R., Valdeolivas, S., 2013, 10.1038/cddis.2013.387

Investigations on the 4-quinolone-3-carboxylic acid motif. 4. Identification of new potent and selective ligands for the cannabinoid type 2 receptor with diverse substitution patterns and antihyperalgesic effects in mice, Corelli, F., Di Marzo, V., Ligresti, A., Frosini, M., Dragoni, S., Maione, S., De Chiaro, M., Luongo, L., Guida, F., Mugnaini, C., Pedani, V., De Rosa, M., Pasquini, S., 2011, 10.1021/jm200476p

Increasing cannabinoid levels by pharmacological and genetic manipulation delay disease progression in SOD1 mice, Greensmith, L., Baker, D., Di Marzo, V., Petrosino, S., Pryce, G., Dick, J.R.T., Bilsland, L.G., 2006, 10.1096/fj.05-4743fje

The anandamide membrane transporter inhibitor, VDM-11, modulates sleep and c-Fos expression in the rat brain, Drucker-Colín, R., Di Marzo, V., Millán-Aldaco, D., Murillo-Rodríguez, E., 2008, 10.1016/j.neuroscience.2008.08.056

Enhanced cognitive performance of dopamine D3 receptor " knock-out" mice in the step-through passive-avoidance test: Assessing the role of the endocannabinoid/endovanilloid systems, Drago, F., Di Marzo, V., Leggio, G.M., Petrosino, S., Tamburella, A., Cristino, L., Micale, V., 2010, 10.1016/j.phrs.2010.02.003

Plasma palmitoylethanolamide (PEA) as a potential biomarker for impaired coronary function, Fabrizio Montecucco, Thomas H. Schindler, Vincenzo Di Marzo, Franco Dallegri, Alain Golay, Estelle Lauer, Sébastien Lenglet, Aurélien Thomas, Zoltan Pataky, Luca Liberale, Aldo Bonaventura, Federico Carbone, Alessandra Quercioli, International Journal of Cardiology, 2017, 10.1016/j.ijcard.2016.12.023

Découvrez nos professeurs et professeures!

Vincenzo Di Marzo

Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Bioinformatique / données massives (big data)

Neurosciences et santé mentale

Reproduction, génétique, périnatalité et développement

Santé cardiovasculaire, respiratoire et métabolisme

Domaines et intérêts de recherche du (de la) professeur(e) :

Neurosciences, santé mentale et toxicomanies

Nutrition et métabolisme

Santé circulatoire et respiratoire

Projets de recherche

Publications

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Encadrement d'étudiant(e)s pour les programmes suivants :

Biologie cellulaire et moléculaire

Médecine moléculaire

Neurobiologie — Neurosciences

Disponibilité d'encadrement d'étudiant(e)s

Direction et personnes-ressources