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Vincent Fradet

Médecin clinicien enseignant agrégé

Vincent Fradet
Centre de recherche sur le cancer
Centre de recherche du CHU de Québec - Université Laval
Nutrition, santé et société (NUTRISS)
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Bioinformatique / données massives (big data)
Oncologie
Santé cardiovasculaire, respiratoire et métabolisme
Santé des populations et pratiques optimales en santé

Domaines et intérêts de recherche du (de la) professeur(e) :

Cancer
  • Cancer la prostate
  • Cancer de l'appareil urinaire
  • Environnement et cancer
  • Nutrition et cancer
  • Diagnostic et détection du cancer
  • Déterminants sociaux du cancer
  • Carcinogénèse
Nutrition et métabolisme
  • Pathologies urogénitales
  • Système génito-urinaire
  • Nutriments
  • Nutrition
  • Métabolisme
  • Produits nutraceutiques et aliments fonctionnels
  • Désordres métaboliques
  • Régulation hormonale
  • Hormones et facteurs de croissance
Santé des populations
  • Habitudes de vie et santé
  • Prévention en santé
  • Pharmaco-épidémiologie
  • Déterminants sociaux de la santé
Information
  • Développement de logiciels
Communication

Projets de recherche

  • Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
  • Les habitudes de vie en cancer de la prostate au coeur d’une médecine personnalisée - Fonds de recherche du Québec - Santé - Chercheurs-boursiers cliniciens - Juniors 1 et 2, Seniors, chercheur principal - 2021-07-01 au 2024-06-30
  • Institut sur la nutrition et les aliments fonctionnels (INAF) - Institut national de recherche scientifique (INRS), Fonds de recherche du Québec - Nature et technologies, Université Laval - Fonds internes, Université McGill, Université du Québec à Rimouski, Université de Sherbrooke - Regroupements stratégiques NT, co-chercheur - 2017-04-01 au 2024-03-31
  • En route towards prebiotic clinical trials for enhancement of immunotherapies in bladder and prostate cancers - The W. Garfield Weston Foundation - Transformational Research, chercheur principal - 2020-06-01 au 2023-05-31
  • Impact of lifestyle on gut barrier function, bacterial translocation and risk of prostate cancer - The W. Garfield Weston Foundation, chercheur principal - 2020-09-01 au 2022-08-31
  • Interaction between environment, diet, physical activities, and sexual habits, in the risk of prostate cancer. Validation of biomarkers to personnalize preventive interventions. - Société de recherche sur le cancer - Compétition GRePEC (SRC/FRSQ/MDEIE), chercheur principal - 2012-10-01 au 2021-12-31
  • (2015-386) ("Project Arms"): 1) The Role of ... in Cardiovascular Disease - A Longitudinal Prostate Cancer Study ("RADICAL PC1") and 2) A Randomized Intervention for Cardiovascular and Lifestyle Risk Factors in ... - Hamilton Health Sciences Corporation, Cancer de la prostate Canada, chercheur principal - 2016-04-01 au 2021-12-25
  • Prebiotics to enhance immunotherapy response in bladder cancer - The W. Garfield Weston Foundation - 2018 Proof-of-Principle Grant Call, co-chercheur - 2019-01-01 au 2021-07-31
  • Territorialiser les systèmes alimentaires : une révolution pour la planète et la santé durable - Alliance santé Québec (AsQ), co-chercheur - 2020-04-01 au 2021-03-31
  • Toward nutritional and epigenomic interventions in prostate cancer prevention and management - Instituts de recherche en santé du Canada - Fonctionnement: Subvention de promotion de l’impact - CCREES, co-chercheur - 2017-10-01 au 2020-09-30
  • (FRSQ 85605) Plateforme méthodologique du CRCEO (statistiques uro-oncologie) - Fondation du CHU de Québec, chercheur principal - 2019-05-30 au 2020-05-29
  • Détresse et satisfactions face au processus informationnel et décisionnel lors d'un cancer de la prostate localisé - Fondation de l'Université Laval, Maison Michel-Sarrazin (La), co-chercheur - 2017-02-01 au 2020-03-31
  • Projet de recherche CaptoMD : Cancer de la prostate - Fondation du CHU de Québec, chercheur principal - 2019-03-22 au 2020-03-21
  • Plateforme méthodologique du Centre de Recherche Clinique et Evaluative en Oncoloie (CRCEO) uro-oncologie - Fondation du CHU de Québec, chercheur principal - 2019-03-05 au 2020-03-04
  • Impact of microbiota on prostate cancer: from gut to tumor microenvironment. - Centre hospitalier universitaire de Montréal, chercheur principal - 2018-12-01 au 2019-12-31

Publications

  • Development and comparability of a Short Food Frequency Questionnaire to Assess Diet in Prostate Cancer Patients: A RADICAL PC Sub-Study, Nevena Savija, Darryl P Leong, Jehonathan Pinthus, Sarah Karampatos, Bobby Shayegan, Rajibul Mian, Sumathy Rangarajan, Vincent Fradet, Russell J de Souza, Andrew Mente, Mahshid Dehghan, Current Developments in Nutrition, 2021, 10.1093/cdn/nzab106
  • Omega-3 Eicosapentaenoic Acid Reduces Prostate Tumor Vascularity, Nikunj Gevariya, Gabriel Lachance, Karine Robitaille, Charles Joly Beauparlant, Lisanne Beaudoin, Éric Fournier, Yves Fradet, Arnaud Droit, Pierre Julien, André Marette, Alain Bergeron, Vincent Fradet, Molecular Cancer Research, 2021, 10.1158/1541-7786.MCR-20-0316
  • The neutrophil-to-lymphocyte ratio (NLR) as a predictive marker of response to abiraterone acetate: A retrospective analysis of the COU302 study, T. Loubersac, M. Nguile-Makao, F. Pouliot, V. Fradet, P. Toren, European Urology Supplements, 2019, 10.1016/s1569-9056(19)30110-1
  • Omega-3 fatty acids decrease prostate cancer progression associated with an anti-tumor immune response in eugonadal and castrated mice, Nikunj Gevariya, Marjorie Besançon, Karine Robitaille, Valérie Picard, Lamoussa Diabaté, Anwar Alesawi, Pierre Julien, Yves Fradet, Alain Bergeron, Vincent Fradet, The Prostate, 2019, 10.1002/pros.23706
  • Omega-3 Fatty Acids Survey in Men under Active Surveillance for Prostate Cancer: from Intake to Prostate Tissue Level, Moussa, H., Nguile-Makao, M., Robitaille, K., Guertin, M.-H., Allaire, J., Pelletier, J.-F., Moreel, X., Gevariya, N., Diorio, C., Desmeules, P., Têtu, B., Lamarche, B., Julien, P., Fradet, V., Nutrients, 2019, 10.3390/nu11071616
  • Use and duration of antibiotic prophylaxis and the rate of urinary tract infection after radical cystectomy for bladder cancer: Results of a multicentric series, Haider, M., Ladurner, C., Mayr, R., Tandogdu, Z., Fritsche, H.-M., Fradet, V., Comploj, E., Pycha, A., Lemire, F., Lacombe, L., Fradet, Y., Toren, P., Lodde, M., Urologic Oncology: Seminars and Original Investigations, 2019, 10.1016/j.urolonc.2019.01.017
  • Prognostic value of urinary prostate cancer antigen 3 (PCA3) during active surveillance of patients with low-risk prostate cancer receiving 5α-reductase inhibitors, Vincent Fradet, Paul Toren, Molière Nguile-Makao, Michele Lodde, Jérome Lévesque, Caroline Léger, André Caron, Alain Bergeron, Tal Ben-Zvi, Louis Lacombe, Frédéric Pouliot, Rabi Tiguert, Thierry Dujardin, Yves Fradet, BJU International, 2018, 10.1111/bju.14041
  • Effects of concentrated long-chain omega-3 polyunsaturated fatty acid supplementation before radical prostatectomy on prostate cancer proliferation, inflammation, and quality of life: Study protocol for a phase IIb, randomized, double-blind, placebo-controlled trial, Guertin, M.-H., Robitaille, K., Pelletier, J.-F., Duchesne, T., Julien, P., Savard, J., Bairati, I., Fradet, V., BMC Cancer, 2018, 10.1186/s12885-017-3979-9
  • Increased Prostate Cancer Glucose Metabolism Detected by 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Localised Gleason 8–10 Prostate Cancers Identifies Very High–risk Patients for Early Recurrence and Resistance to Castration, Lavallée, E., Bergeron, M., Buteau, F.-A., Blouin, A.-C., Duchesnay, N., Dujardin, T., Tiguert, R., Lacombe, L., Fradet, V., Makao-Nguile, M., Fradet, Y., Beauregard, J.-M., Pouliot, F., European Urology Focus, 2018, 10.1016/j.euf.2018.03.008
  • Urology residents on call: Investigating the workload and relevance of calls, Thériault, B., Marceau-Grimard, M., Blais, A.-S., Fradet, V., Moore, K., Cloutier, J., Canadian Urological Association Journal, 2018, 10.5489/cuaj.4333
  • Metabolic Imaging of Prostate Cancer Reveals Intrapatient Intermetastasis Response Heterogeneity to Systemic Therapy, Fannie Morin, Jean-Mathieu Beauregard, Michelle Bergeron, Molière Nguile Makao, Louis Lacombe, Vincent Fradet, Yves Fradet, Frédéric Pouliot, European Urology Focus, 2017, 10.1016/j.euf.2017.02.007
  • Preoperative nutritional factors and outcomes after radical cystectomy: A narrative review, Allaire, J., Ben-Zvi, T., Lamarche, B., Robitaille, K., Fradet, Y., Lacombe, L., Fradet, V., Canadian Urological Association Journal, 2017, 10.5489/cuaj.4471
  • Prospective Evaluation of Nutritional Factors to Predict the Risk of Complications for Patients Undergoing Radical Cystectomy: A Cohort Study, Allaire, J., Léger, C., Ben-Zvi, T., Nguilé-Makao, M., Fradet, Y., Lacombe, L., Fradet, V., Nutrition and Cancer, 2017, 10.1080/01635581.2017.1367941
  • Validation of the French-Canadian version of the Expanded Prostate Cancer Index Composite (EPIC) in a French-Canadian population, Vigneault, É., Savard, J., Savard, M.-H., Ivers, H., Després, P., Foster, W., Martin, A.-G., Fradet, V., Canadian Urological Association Journal, 2017, 10.5489/cuaj.4428
  • Assessing Cancer Risk on Novel 29 MHz Micro-Ultrasound Images of the Prostate: Creation of the Micro-Ultrasound Protocol for Prostate Risk Identification, Ghai, S., Eure, G., Fradet, V., Hyndman, M.E., McGrath, T., Wodlinger, B., Pavlovich, C.P., Journal of Urology, 2016, 10.1016/j.juro.2015.12.093
  • Phase II drug-metabolizing polymorphisms and smoking predict recurrence of nonâ€"muscle- invasive bladder cancer: A geneâ€"smoking interaction, Lacombe, L., Fradet, V., Levesque, E., Pouliot, F., Larue, H., Bergeron, A., Hovington, H., Caron, A., Nguile-Makao, M., Harvey, M., Fradet, Y., Guillemette, C., Cancer Prevention Research, 2016, 10.1158/1940-6207.CAPR-15-0069
  • Renal cell carcinoma with thrombus extending to the hepatic veins or right atrium: Operative strategies based on 41 consecutive patients, Gagné-Loranger, M., Lacombe, L., Pouliot, F., Fradet, V., Dagenais, F., European Journal of Cardio-thoracic Surgery, 2016, 10.1093/ejcts/ezw023
  • Burden of illness of bone metastases in prostate cancer patients in Québec, Canada: A population-based analysis, Perrault, L., Fradet, V., Lauzon, V., Lelorier, J., Mitchell, D., Habib, M., Journal of the Canadian Urological Association, 2015, 10.5489/cuaj.2707
  • Comparison of digital image analysis and visual scoring of KI-67 in prostate cancer prognosis after prostatectomy, Desmeules, P., Hovington, H., Nguilé-Makao, M., Léger, C., Caron, A., Lacombe, L., Fradet, Y., Têtu, B., Fradet, V., Diagnostic Pathology, 2015, 10.1186/s13000-015-0294-0
  • FDG-PET/CT for pre-operative staging and prognostic stratification of patients with high-grade prostate cancer at biopsy, Beauregard, J.-M., Blouin, A.-C., Fradet, V., Caron, A., Fradet, Y., Lemay, C., Lacombe, L., Dujardin, T., Tiguert, R., Rimac, G., Bouchard, F., Pouliot, F., Cancer Imaging, 2015, 10.1186/s40644-015-0038-0
  • Intermittent vs continuous androgen deprivation therapy for prostate cancer, Magnan, S., Zarychanski, R., Pilote, L., Bernier, L., Shemilt, M., Vigneault, E., Fradet, V., Turgeon, A.F., JAMA Oncology, 2015, 10.1001/jamaoncol.2015.2895
  • Malignant mesothelioma of the tunica vaginalis testis: comprehensive review of literature and case report, Alesawi, A.M., Levesque, J., Fradet, V., Journal of Clinical Urology, 2015, 10.1177/2051415813511082
  • Validation of the omega-3 fatty acid intake measured by a web-based food frequency questionnaire against omega-3 fatty acids in red blood cells in men with prostate cancer, Allaire, J., Moreel, X., Labonté, M.-E., Léger, C., Caron, A., Julien, P., Lamarche, B., Fradet, V., European Journal of Clinical Nutrition, 2015, 10.1038/ejcn.2015.7
  • Diagnostic performance of ultrasound for macroscopic hematuria in the era of multidetector computed tomography urography, Rhéaume-Lanoie, J., Lepanto, L., Fradet, V., Billiard, J.-S., Tang, A., Canadian Association of Radiologists Journal, 2014, 10.1016/j.carj.2013.08.001
  • IL-8 secretion in primary cultures of prostate cells is associated with prostate cancer aggressiveness, Neveu, B., Moreel, X., Deschênes-Rompré, M.-P., Bergeron, A., LaRue, H., Ayari, C., Fradet, Y., Fradet, V., Research and Reports in Urology, 2014, 10.2147/RRU.S58643
  • Prostatic and dietary omega-3 fatty acids and prostate cancer progression during active surveillance, Moreel, X., Allaire, J., Léger, C., Caron, A., Labonté, M.-È., Lamarche, B., Julien, P., Desmeules, P., Têtu, B., Fradet, V., Cancer Prevention Research, 2014, 10.1158/1940-6207.CAPR-13-0349
  • Risk factors for bladder cancer recurrence after nephroureterectomy for upper tract urothelial tumors: Results from the Canadian Upper Tract Collaboration, Fradet, V., Mauermann, J., Kassouf, W., Rendon, R., Jacobsen, N., Fairey, A., Izawa, J., Kapoor, A., Black, P., Tanguay, S., Chin, J., So, A., Lattouf, J.-B., Bell, D., Saad, F., Sheyegan, B., Drachenberg, D., Cagiannos, I., Lacombe, L., Urologic Oncology: Seminars and Original Investigations, 2014, 10.1016/j.urolonc.2014.04.006
  • High level of mature tumor-infiltrating dendritic cells predicts progression to muscle invasion in bladder cancer, Ayari, C., Larue, H., Hovington, H., Caron, A., Bergeron, A., Têtu, B., Fradet, V., Fradet, Y., Human Pathology, 2013, 10.1016/j.humpath.2013.01.014
  • Reply from Authors re: Martin Spahn, Steven Joniau. Positive surgical margin at radical prostatectomy: Futile or surgeon-dependent predictor of prostate cancer death? Eur Urol 2013;64:26-8: Adjuvant versus salvage radiotherapy in patients with positive surgical margins at radical prostatectomy: That is the question, Mauermann, J., Fradet, V., Fradet, Y., European Urology, 2013, 10.1016/j.eururo.2012.10.047
  • The impact of solitary and multiple positive surgical margins on hard clinical end points in 1712 adjuvant treatment-naive pT2-4 N0 radical prostatectomy patients, Mauermann, J., Fradet, V., Lacombe, L., Dujardin, T., Tiguert, R., Tetu, B., Fradet, Y., European Urology, 2013, 10.1016/j.eururo.2012.08.002
  • Green tea for ovarian cancer prevention and treatment: A systematic review of the in vitro, in vivo and epidemiological studies, Trudel, D., Labbé, D.P., Bairati, I., Fradet, V., Bazinet, L., Têtu, B., Gynecologic Oncology, 2012, 10.1016/j.ygyno.2012.04.048
  • The impact of germline genetic variations in hydroxysteroid (17-beta) dehydrogenases on prostate cancer outcomes after prostatectomy, Audet-Walsh, É., Bellemare, J., Lacombe, L., Fradet, Y., Fradet, V., Douville, P., Guillemette, C., Lévesque, É., European Urology, 2012, 10.1016/j.eururo.2011.12.021
  • Dietary omega-3 fatty acids, genetic variation and risk of breast and prostate cancers, Mauermann, J., Pouliot, F., Fradet, V., World Review of Nutrition and Dietetics, 2011, 10.1159/000327805
  • Poor agreement of prostate specific antigen doubling times calculated using ultrasensitive versus standard prostate specific antigen values: Important impact on risk assessment, Reese, A.C., Fradet, V., Whitson, J.M., Davis, C.B., Carroll, P.R., Journal of Urology, 2011, 10.1016/j.juro.2011.07.119
  • SRD5A polymorphisms and biochemical failure after radical prostatectomy, Audet-Walsh, E., Bellemare, J., Nadeau, G., Lacombe, L., Fradet, Y., Fradet, V., Huang, S.-P., Bao, B.-Y., Douville, P., Girard, H., Guillemette, C., Lévesque, E., European Urology, 2011, 10.1016/j.eururo.2011.06.020
  • Prostate cancer managed with active surveillance: Role of anatomic MR imaging and MR spectroscopic imaging, Fradet, V., Kurhanewicz, J., Cowan, J.E., Karl, A., Coakley, F.V., Shinohara, K., Carroll, P.R., International Braz J Urol, 2010, 10.1590/S1677-55382010000500019
  • Prostate cancer managed with active surveillance: Role of anatomic MR imaging and MR spectroscopic imaging, Fradet, V., Kurhanewicz, J., Cowan, J.E., Karl, A., Coakley, F.V., Shinohara, K., Carroll, P.R., Radiology, 2010, 10.1148/radiol.10091147
  • Urologist density and county-level urologic cancer mortality, Odisho, A.Y., Cooperberg, M.R., Fradet, V., Ahmad, A.E., Carroll, P.R., Journal of Clinical Oncology, 2010, 10.1200/JCO.2009.26.9597
  • Dietary omega-3 fatty acids, Cyclooxygenase-2 genetic variation, and aggressive prostate cancer risk, Fradet, V., Cheng, L., Casey, G., Witte, J.S., Clinical Cancer Research, 2009, 10.1158/1078-0432.CCR-08-2503
  • Geographic Distribution of Urologists Throughout the United States Using a County Level Approach, Odisho, A.Y., Fradet, V., Cooperberg, M.R., Ahmad, A.E., Carroll, P.R., Journal of Urology, 2009, 10.1016/j.juro.2008.10.034
  • Is the Complication Rate of Radical Cystectomy Predictive of the Complication Rate of Other Urological Procedures?, Fradet, V., Allareddy, V., Aaronson, D.S., Konety, B.R., Journal of Urology, 2009, 10.1016/j.juro.2008.11.016
  • Pathological Outcomes of Candidates for Active Surveillance of Prostate Cancer, Conti, S.L., Dall'Era, M., Fradet, V., Cowan, J.E., Simko, J., Carroll, P.R., Journal of Urology, 2009, 10.1016/j.juro.2008.11.107
  • Penile sonographic and clinical characteristics in men with peyronie's disease, Smith, J.F., Brant, W.O., Fradet, V., Shindel, A.W., Vittinghoff, E., Chi, T., Huang, Y.-C., Davis, C.B., Conti, S., Lue, T.F., Journal of Sexual Medicine, 2009, 10.1111/j.1743-6109.2009.01438.x
  • Prospective Assessment of Malnutrition in Urologic Patients, Karl, A., Rittler, P., Buchner, A., Fradet, V., Speer, R., Walther, S., Stief, G.C., Urology, 2009, 10.1016/j.urology.2008.12.037
  • ω-3 Fatty acids, genetic variants in COX-2 and prostate cancer, Reese, A.C., Fradet, V., Witte, J.S., Journal of Nutrigenetics and Nutrigenomics, 2009, 10.1159/000235565
  • A delay in radical cystectomy of >3 months is not associated with a worse clinical outcome [2], Fradet, V., Konety, B.R., BJU International, 2008, 10.1111/j.1464-410X.2007.07394_2.x
  • Re: Results from three municipal hospitals regarding radical cystectomy on elderly patients [1], Fradet, V., Konety, B.R., International Braz J Urol, 2008, 10.1590/S1677-55382008000100014
  • Management of hepatic granulomatous tuberculosis complicating intravesical BCG for superficial bladder cancer, Fradet, V., Gaudreau, C., Perrotte, P., Côté, J., Paquin, J.-M., Journal of the Canadian Urological Association, 2007
  • The 2002 AJCC pT2 substages confer no prognostic information on the rate of biochemical recurrence after radical prostatectomy, Chun, F.K.-H., Briganti, A., Lebeau, T., Fradet, V., Steuber, T., Walz, J., Schlomm, T., Eichelberg, C., Haese, A., Erbersdobler, A., McCormack, M., Perrotte, P., Graefen, M., Huland, H., Karakiewicz, P.I., European Urology, 2006, 10.1016/j.eururo.2005.12.009
  • An epidural abscess following transrectal ultrasound-guided biopsies of the prostate., Fradet, V., McCormack, M., Perrotte, P., Karakiewicz, P., Saad, F., The Canadian journal of urology, 2005
  • Nuclear factor-κB nuclear localization is predictive of biochemical recurrence in patients with positive margin prostate cancer, Fradet, V., Lessard, L., Bégin, L.R., Karakiewicz, P., Mes Masson, A.-M., Saad, F., Clinical Cancer Research, 2004, 10.1158/1078-0432.CCR-04-0764

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Gabrielle Villeneuve - Maitrîse avec mémoire - En cours
  • Roxane Tourigny - Maitrîse avec mémoire - En cours
  • Amenan Prisca Nadege Kone - Post-doctorat - En cours
  • Ruijing Dong - Doctorat - En cours
  • Abdelkrim Ziad - Doctorat - En cours
  • Jalal Laaraj - Doctorat - En cours
  • Lamoussa Diabaté - Doctorat - En cours
  • Louis-Alexis Porlier - Maitrîse avec mémoire - En cours
  • Justine Desrochers-Goyette - Maitrîse avec mémoire - En cours
  • Lisanne Beaudoin - Maitrîse avec mémoire - En cours
  • Janie Allaire - Maitrîse avec mémoire - 2016/01
  • Nikunj Gevariya - Doctorat - 2019/01

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.

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Vice-décanat à la recherche et aux études supérieures
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Université Laval
1050, avenue de la Médecine,  local 4645
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vdres@fmed.ulaval.ca

Jacques Simard
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vice-doyen.recherche-et-etudes-superieures@fmed.ulaval.ca

Louise Laperrière
Adjointe au vice-doyen à la recherche et aux études supérieures
louise.laperriere@fmed.ulaval.ca 

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