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Véronique Moulin

Professeure titulaire

Véronique Moulin
Centre de recherche en organogenèse expérimentale
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Médecine régénératrice et moléculaire

Domaines et intérêts de recherche du (de la) professeur(e) :

Appareil locomoteur et arthrite
  • Peau
  • Fibroses
  • Affections cutanées
  • Maladies des tissus conjonctifs
  • Tissu conjonctif

Projets de recherche

  • Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
  • Action des microvésicules dans les tissus solides - Conseil de recherches en sciences naturelles et génie Canada, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2019-04-01 au 2024-03-31
  • Mise au point par génie tissulaire d'un modèle de cicatrisation cutanée contenant des cellules immunitaires - MITACS Inc. - Accélération Québec (MITACS et gouvernement provincial), chercheur principal - 2019-01-27 au 2023-02-28
  • The Canadian National Transplant Research Program : Increasing Donation and Improving Transplantation Outcomes - Instituts de recherche en santé du Canada - Autre : Recherche sur la transplantation, University of Alberta, co-chercheur - 2013-04-01 au 2022-03-31
  • Utilisation de vésicules extracellulaires pour livrer les composants de la technologie d’édition du génome CRISPR/PRIME - Fonds de recherche du Québec - Santé - Réseaux thématiques de recherche, co-chercheur - 2021-04-01 au 2022-03-31
  • Self-Assembly Skin Substitutes (SASS) for the treatment of acute wounds of Canadian burn patients - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Réseau de centres d'excellence (RCE), chercheur principal - 2020-01-01 au 2022-01-31
  • Présentation des vos résultats de recherche à une rencontre scientifique à Denver - CHU de Québec – Université Laval – Hôpital l'Enfant-Jésus, chercheur principal - 2020-04-17 au 2021-04-16
  • Bioengineering and Long-term Storage of Complex Tissue and Organ Constructs - Secrétariat des programmes interorganismes à l’intention des établissements - Nouvelles frontières en recherche, Université d'Ottawa, co-chercheur - 2020-03-31 au 2021-03-31
  • Impact des exosomes cornéens sur la guérison des plaies de cornées humaines : étude in vitro dans un modèle reconstruit par génie tissulaire - Fonds de recherche du Québec - Santé - Réseaux thématiques de recherche, co-chercheur - 2020-04-01 au 2021-03-31
  • Développement de procédures d’opération standard pour l’expédition de matériel biologique à température de la pièce - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Réseau de centres d'excellence (RCE), chercheur principal - 2017-09-15 au 2020-03-31
  • Extracellular vesicles secreted by uveal melanoma cells: role and clinical value - Fonds de recherche du Québec - Santé - Programme Réseautage national et international, co-chercheur - 2018-04-01 au 2020-03-31
  • Centre de recherche en arthrite de l'Université Laval - Université Laval - Fonds internes - BDR - Entités de recherche en émergence, co-chercheur - 2019-01-01 au 2020-01-31
  • Bourses-Desjardins et Axe Médecine régénératrice - Fondation du CHU de Québec, chercheur principal - 2019-01-17 au 2020-01-16

Publications

  • Granulation tissue myofibroblasts during normal and pathological skin healing: The interaction between their secretome and the microenvironment, Syrine Arif, Emilie Attiogbe, Véronique J. Moulin, Wound Repair and Regeneration, 2021, 10.1111/wrr.12919
  • GPR43 regulates sodium butyrate-induced angiogenesis and matrix remodeling, Pollyana Ribeiro Castro, Lucas Felipe Fernandes Bittencourt, Sébastien Larochelle, Silvia Passos Andrade, Charles Reay Mackay, Mark Slevin, Véronique J. Moulin, Lucíola Silva Barcelos, American Journal of Physiology-Heart and Circulatory Physiology, 2021, 10.1152/ajpheart.00515.2019
  • Shedding of proangiogenic microvesicles from hypertrophic scar myofibroblasts, Alexandra Laberge, Mays Merjaneh, Syrine Arif, Sébastien Larochelle, Véronique J. Moulin, Experimental Dermatology, 2021, 10.1111/exd.14178
  • PLGF-1 contained in normal wound myofibroblast-derived microvesicles stimulated collagen production by dermal fibroblasts, Syrine Arif, Sébastien Larochelle, Véronique J. Moulin, Journal of Cell Communication and Signaling, 2020, 10.1007/s12079-020-00572-5
  • Biofabrication and preclinical evaluation of a large-sized human self-assembled skin substitute, Fabien Kawecki, Dominique Mayrand, Akram Ayoub, Emilie Attiogbe, Lucie Germain, Francois A Auger, Veronique J Moulin, Biomedical Materials, 2020, 10.1088/1748-605X/abbdbe
  • α‐2‐Macroglobulin induces the shedding of microvesicles from cutaneous wound myofibroblasts, Alexandra Laberge, Akram Ayoub, Syrine Arif, Sébastien Larochelle, Alain Garnier, Véronique J. Moulin, Journal of Cellular Physiology, 2019, 10.1002/jcp.27794
  • Microvesicles: Intercellular messengers in cutaneous wound healing, Alexandra Laberge, Syrine Arif, Véronique J. Moulin, Journal of Cellular Physiology, 2018, 10.1002/jcp.26426
  • Autologous bilayered self-assembled skin substitutes (Sasss) as permanent grafts: A case series of 14 severely burned patients indicating clinical effectiveness, Germain, L., Larouche, D., Nedelec, B., Perreault, I., Duranceau, L., Bortoluzzi, P., Cloutier, C.B., Genest, H., Caouette-Laberge, L., Dumas, A., Bussière, A., Boghossian, E., Kanevsky, J., Leclerc, Y., Lee, J., Nguyen, M.T., Bernier, V., Knoppers, B.M., Moulin, V.J., Auger, F.A., European Cells and Materials, 2018, 10.22203/eCM.v036a10
  • Characterization of epidermal lipoxygenase expression in normal human skin and tissue-engineered skin substitutes, Simard-Bisson, C., Parent, L.A., Moulin, V.J., De Laclos, B.F., Journal of Histochemistry and Cytochemistry, 2018, 10.1369/0022155418788117
  • The Role of Microvesicles in Cutaneous Wound Healing, Laberge, A., Moulin, V.J., Wound Healing: Stem Cells Repair and Restorations, Basic and Clinical Aspects, 2018, 10.1002/9781119282518.ch4
  • Translating the combination of gene therapy and tissue engineering for treating recessive dystrophic epidermolysis bullosa, Piaceski, A.D., Larouche, D., Ghani, K., Bisson, F., Ghio, S.C., Larochelle, S., Moulin, V.J., Caruso, M., Germain, L., European Cells and Materials, 2018, 10.22203/eCM.v035a06
  • Evaluation of contractile phenotype in airway smooth muscle cells isolated from endobronchial biopsy and tissue specimens from horses, Vargas, A., Peltier, A., Dubé, J., Lefebvre-Lavoie, J., Moulin, V., Goulet, F., Lavoie, J.-P., American Journal of Veterinary Research, 2017, 10.2460/ajvr.78.3.359
  • In Vivo Evaluation and Imaging of a Bilayered Self-Assembled Skin Substitute Using a Decellularized Dermal Matrix Grafted on Mice, Beaudoin Cloutier, C., Goyer, B., Perron, C., Guignard, R., Larouche, D., Moulin, V.J., Germain, L., Gauvin, R., Auger, F.A., Tissue Engineering - Part A, 2017, 10.1089/ten.tea.2016.0296
  • Pro-angiogenic capacities of microvesicles produced by skin wound myofibroblasts, Merjaneh, M., Langlois, A., Larochelle, S., Cloutier, C.B., Ricard-Blum, S., Moulin, V.J., Angiogenesis, 2017, 10.1007/s10456-017-9554-9
  • Improved Methods to Produce Tissue-Engineered Skin Substitutes Suitable for the Permanent Closure of Full-Thickness Skin Injuries, Larouche, D., Cantin-Warren, L., Desgagné, M., Guignard, R., Martel, I., Ayoub, A., Lavoie, A., Gauvin, R., Auger, F.A., Moulin, V.J., Germain, L., BioResearch Open Access, 2016, 10.1089/biores.2016.0036
  • The role of myofibroblasts in normal skin wound healing, Moulin, V.J., Myofibroblasts: Origin, Function and Role in Disease, 2016
  • Anticancer properties of chitosan on human melanoma are cell line dependent, Gibot, L., Chabaud, S., Bouhout, S., Bolduc, S., Auger, F.A., Moulin, V.J., International Journal of Biological Macromolecules, 2015, 10.1016/j.ijbiomac.2014.08.033
  • Enhancing repair of full-thickness excisional wounds in a murine model: Impact of tissue-engineered biological dressings featuring human differentiated adipocytes, Morissette Martin, P., Maux, A., Laterreur, V., Mayrand, D., Gagné, V.L., Moulin, V.J., Fradette, J., Acta Biomaterialia, 2015, 10.1016/j.actbio.2015.04.036
  • Production of a Bilayered Self-Assembled Skin Substitute Using a Tissue-Engineered Acellular Dermal Matrix, Beaudoin Cloutier, C., Guignard, R., Bernard, G., Gauvin, R., Larouche, D., Lavoie, A., Lacroix, D., Moulin, V.J., Germain, L., Auger, F.A., Tissue Engineering - Part C: Methods, 2015, 10.1089/ten.tec.2015.0258
  • Role of seaweed laminaran from Saccharina longicruris on matrix deposition during dermal tissue-engineered production, Ayoub, A., Pereira, J.M., Rioux, L.-E., Turgeon, S.L., Beaulieu, M., Moulin, V.J., International Journal of Biological Macromolecules, 2015, 10.1016/j.ijbiomac.2015.01.017
  • Human skin fibroblast response is differentially regulated by galactofucan and low molecular weight galactofucan, Rioux, L.-E., Moulin, V., Beaulieu, M., Turgeon, S.L., Bioactive Carbohydrates and Dietary Fibre, 2013, 10.1016/j.bcdf.2013.03.004
  • Prospective study on the treatment of lower-extremity chronic venous and mixed ulcers using tissue-engineered skin substitute made by the self-assembly approach, Boa, O., Cloutier, C.B., Genest, H., Labbé, R., Rodrigue, B., Soucy, J., Roy, M., Arsenault, F., Ospina, C.E., Dubé, N., Rochon, M.-H., Larouche, D., Moulin, V.J., Germain, L., Auger, F.A., Advances in Skin and Wound Care, 2013, 10.1097/01.ASW.0000433102.48268.2a
  • Reconstitution of skin fibrosis development using a tissue engineering approach, Moulin, V.J., Methods in Molecular Biology, 2013, 10.1007/978-1-62703-227-8_19
  • Angiogenic properties of myofibroblasts isolated from normal human skin wounds, Mayrand, D., Laforce-Lavoie, A., Larochelle, S., Langlois, A., Genest, H., Roy, M., Moulin, V.J., Angiogenesis, 2012, 10.1007/s10456-012-9253-5
  • Enhanced secretion of TIMP-1 by human hypertrophic scar keratinocytes could contribute to fibrosis, Simon, F., Bergeron, D., Larochelle, S., Lopez-Vallé, C.A., Genest, H., Armour, A., Moulin, V.J., Burns, 2012, 10.1016/j.burns.2011.09.001
  • Human keratinocytes respond to direct current stimulation by increasing intracellular calcium: Preferential response of poorly differentiated cells, Dubé, J., Rochette-Drouin, O., Lévesque, P., Gauvin, R., Roberge, C.J., Auger, F.A., Goulet, D., Bourdages, M., Plante, M., Moulin, V.J., Germain, L., Journal of Cellular Physiology, 2012, 10.1002/jcp.23008
  • Apoptosis modulation as a promising target for treatment of systemic sclerosis, Chabaud, S., Moulin, V.J., International Journal of Rheumatology, 2011, 10.1155/2011/495792
  • Decreased secretion of MMP by non-lesional late-stage scleroderma fibroblasts after selection via activation of the apoptotic fas-pathway, Chabaud, S., Corriveau, M.-P., Grodzicky, T., Senécal, J.-L., Chartier, S., Raymond, Y., Moulin, V.J., Journal of Cellular Physiology, 2011, 10.1002/jcp.22520
  • New ligament healing model based on tissue-engineered collagen scaffolds, Robayo, L.M., Moulin, V.J., Tremblay, P., Cloutier, R., Lamontagne, J., Larkin, A.-M., Chabaud, S., Simon, F., Islam, N., Goulet, F., Wound Repair and Regeneration, 2011, 10.1111/j.1524-475X.2010.00640.x
  • Restoration of the transepithelial potential within tissue-engineered human skin in vitro and during the wound healing process in vivo, Dubé, J., Rochette-Drouin, O., Lévesque, P., Gauvin, R., Roberge, C.J., Auger, F.A., Goulet, D., Bourdages, M., Plante, M., Germain, L., Moulin, V.J., Tissue Engineering - Part A, 2010, 10.1089/ten.tea.2010.0030
  • Shedding of microparticles by myofibroblasts as mediator of cellular cross-talk during normal wound healing, Moulin, V.J., Mayrand, D., Messier, H., Martinez, M.C., Lopez-Vallé, C.A., Genest, H., Journal of Cellular Physiology, 2010, 10.1002/jcp.22268
  • The fibrotic phenotype of systemic sclerosis fibroblasts varies with disease duration and severity of skin involvement: Reconstitution of skin fibrosis development using a tissue engineering approach, Corriveau, M.-P., Boufaied, I., Lessard, J., Chabaud, S., Senécal, J.-L., Grodzicky, T., Chartier, S., Raymond, Y., Moulin, V.J., Journal of Pathology, 2009, 10.1002/path.2482
  • Epidermis promotes dermal fibrosis: Role in the pathogenesis of hypertrophic scars, Bellemare, J., Roberge, C.J., Bergeron, D., Lopez-Vallé, C.A., Roy, M., Moulin, V.J., Journal of Pathology, 2005, 10.1002/path.1737
  • Normal Skin Wound and Hypertrophic Scar Myofibroblasts Have Differential Responses to Apoptotic Inductors, Moulin, V., Larochelle, S., Langlois, C., Thibault, I., Lopez-Vallé, C.A., Roy, M., Journal of Cellular Physiology, 2004, 10.1002/jcp.10415
  • Sensitivity of myofibroblasts to H2O2-mediated apoptosis and their antioxidant cell network, Larochelle, S., Langlois, C., Thibault, I., Lopez-Vallé, C.A., Roy, M., Moulin, V., Journal of Cellular Physiology, 2004, 10.1002/jcp.20003
  • Tissue-engineered human asthmatic bronchial equivalents, Paquette, J.-S., Moulin, V., Tremblay, P., Bernier, V., Boutet, M., Laviolette, M., Auger, F.A., Boulet, L.-P., Goulet, F., Qvortrup, K., Bongrand, P., European Cells and Materials, 2004, 10.22203/eCM.v007a01
  • Tissue-engineered skin substitutes: From in vitro constructs to in vivo applications, Auger, F.A., Berthod, F., Moulin, V., Pouliot, R., Germain, L., Biotechnology and Applied Biochemistry, 2004
  • Tissue engineering: A tool to understand the physiological mechanisms,Le génie tissulaire au service de la compréhension du vivant, Moulin, V., Goulet, F., Berthod, F., Germain, L., Auger, F.A., Medecine/Sciences, 2003
  • Differential expression of collagen integrin receptor on fetal vs. adult skin fibroblasts: Implication in wound contraction during healing, Moulin, V., Plamondon, M., British Journal of Dermatology, 2002, 10.1046/j.1365-2133.2002.04975.x
  • Engineering human tissues for in vivo applications, Germain, L., Goulet, F., Moulin, V., Berthod, F., Auger, F.A., Annals of the New York Academy of Sciences, 2002, 10.1111/j.1749-6632.2002.tb03099.x
  • Fetal and adult human skin fibroblasts display intrinsic differences in contractile capacity, Moulin, V., Tam, B.Y.Y., Castilloux, G., Auger, F.A., O'Connor-McCourt, M.D., Philip, A., Germain, L., Journal of Cellular Physiology, 2001, 10.1002/jcp.1110
  • Mechanisms of wound reepithelialization: Hints from a tissue-engineered reconstructed skin to long-standing questions, Laplante, A.F., Germain, L., Auger, F.A., Moulin, V., FASEB Journal, 2001, 10.1096/fj.01-0250com
  • Morphological changes of human skin cells exposed to a DC electric field In vitro using a new exposure system, Méthot, S., Moulin, V., Rancourt, D., Bourdages, M., Goulet, D., Plante, M., Auger, F.A., Germain, L., Canadian Journal of Chemical Engineering, 2001, 10.1002/cjce.5450790428
  • Optimization of a cutaneous wound-healing model for the screening of pharmaceutical compounds, Laplante, A.F., Germain, L., Auger, F.A., Moulin, V., Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling, 2000
  • Role of wound healing myofibroblasts on re-epithelialization of human skin, Moulin, V., Auger, F.A., Garrel, D., Germain, L., Burns, 2000, 10.1016/S0305-4179(99)00091-1
  • What's new in human wound-healing myofibroblasts?, Moulin, V., Garrel, D., Auger, F.A., O'Connor-McCourt, M., Castilloux, G., Germain, L., Current topics in pathology. Ergebnisse der Pathologie, 1999
  • Expression of heat shock proteins in mouse skin during wound healing, Laplante, A.F., Moulin, V., Auger, F.A., Landry, J., Li, H., Morrow, G., Tanguay, R.M., Germain, L., Journal of Histochemistry and Cytochemistry, 1998, 10.1177/002215549804601109
  • Modulated response to cytokines of human wound healing myofibroblasts compared to dermal fibroblasts, Moulin, V., Castilloux, G., Auger, F.A., Garrel, D., O'Connor-McCourt, M.D., Germain, L., Experimental Cell Research, 1998, 10.1006/excr.1997.3827
  • Platelet releasate treatment improves skin healing in diabetic rats through endogenous growth factor secretion., Moulin, V., Lawny, F., Barritault, D., Caruelle, J.P., Cellular and molecular biology (Noisy-le-Grand, France), 1998
  • Tissue-engineered human skin substitutes developed from collagen-populated hydrated gels: Clinical and fundamental applications, Auger, F.A., Rouabhia, M., Goulet, F., Berthod, F., Moulin, V., Germain, L., Medical and Biological Engineering and Computing, 1998, 10.1007/BF02518887
  • Fetal and postnatal sera differentially modulate human dermal fibroblast phenotypic and functional features in vitro, Moulin, V., Auger, F.A., O'Connor-McCourt, M., Germain, L., Journal of Cellular Physiology, 1997, 10.1002/(SICI)1097-4652(199704)171:1<1::AID-JCP1>3.0.CO;2-S
  • In vitro models to study wound healing fibroblasts, Moulin, V., Castilloux, G., Jean, A., Garrel, D.R., Auger, F.A., Germain, L., Burns, 1996, 10.1016/0305-4179(95)00167-0
  • Growth factors in skin wound healing, Moulin, V., European Journal of Cell Biology, 1995

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Jason Dagher - Maitrîse avec mémoire - En cours
  • Amélie Langlois - Maitrîse avec mémoire - 2013/09
  • Elnaz Salekzamani - Maitrîse avec mémoire - 2013/09
  • Akram Ayoub - Maitrîse avec mémoire - 2014/05
  • Pascal Morissette Martin - Maitrîse avec mémoire - 2015/01
  • Jadson Moreira Pereira - Doctorat - 2019/05
  • Alexandra Laberge - Maitrîse avec mémoire - 2019/09
  • Yanis Chaib - Maitrîse avec mémoire - 2020/01
  • Maude Vaillancourt-Audet - Maitrîse avec mémoire - 2020/01

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.

Direction et personnes-ressources

Vice-décanat à la recherche et aux études supérieures
Pavillon Ferdinand-Vandry
Université Laval
1050, avenue de la Médecine,  local 4645
Québec, Québec G1V 0A6
Canada

Renseignements - Secrétariat :
vdres@fmed.ulaval.ca

Jacques Simard
Vice-doyen à la recherche et aux études supérieures
vice-doyen.recherche-et-etudes-superieures@fmed.ulaval.ca

Louise Laperrière
Adjointe au vice-doyen à la recherche et aux études supérieures
louise.laperriere@fmed.ulaval.ca 

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