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Steve Lacroix

Professeur titulaire

Steve Lacroix
Centre thématique de recherche en neurosciences
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Immunologie-infectiologie
Médecine régénératrice et moléculaire
Neurosciences et santé mentale

Domaines et intérêts de recherche du (de la) professeur(e) :

Neurosciences, santé mentale et toxicomanies
  • Hémiplégie et paraplégie
  • Maladies inflammatoires du système nerveux central
  • Maladies neuroimmunologiques
  • Traumatismes crânio-encéphaliques et de la moelle épinière
  • Sclérose en plaques
  • Neurotoxicité
  • Douleur
  • Neurogénèse et gliogénèse

Projets de recherche

  • Elucidating the role of the IL-1 system in the pathogenesis of CNS autoimmunity - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2020-04-01 au 2025-03-31
  • Platelets and neutrophils: the two culprits mediating pain in inflammatory arthritis - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2020-04-01 au 2025-03-31
  • Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
  • Thérapie génique ciblée dans un modèle de sclérose en plaques - Fonds de recherche du Québec - Santé, co-chercheur - 2021-05-01 au 2024-04-30
  • Manipulating the neuroimmune response to promote spinal cord repair - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2019-04-01 au 2024-03-31
  • Interleukin-1 alpha mediates secondary degeneration and neuropathic pain after spinal cord injury - Wings for Life Spinal Cord Research Foundation - Research Grant, chercheur principal - 2020-04-01 au 2023-03-31
  • Platelets and neutrophils: the two culprits mediating pain in inflammatory arthritis - La société d'arthrite, co-chercheur - 2020-01-01 au 2022-12-31
  • Turnbull-Tator Award in Spinal Cord Injury and Concussion Research - Brain Canada Foundation, chercheur principal - 2021-07-01 au 2022-06-30
  • The interleukin-1 cytokine system as a target for the treatment of MS - Société canadienne de la sclérose en plaques, chercheur principal - 2019-04-01 au 2022-03-31
  • Étude des interactions entre les cellules immunitaires et les composantes de la barrière hématoencéphalique - Fonds de recherche du Québec - Santé - Programme d'appui à la recherche pour les enseignants-chercheurs de collège, chercheur principal - 2017-07-01 au 2020-06-30
  • Mécanismes cellulaires et moléculaires modulant la régénération de nerfs lésés - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2015-04-01 au 2020-03-31
  • 3rd Neuroforum of the CHU de Québec - Université Laval Research Center: A seminar series of le2aders in neuroscience - Instituts de recherche en santé du Canada - Subvention de planification et dissémination, chercheur principal - 2020-01-01 au 2020-03-31

Publications

  • The alarmin interleukin-1α triggers secondary degeneration through reactive astrocytes and endothelium after spinal cord injury, Floriane Bretheau, Adrian Castellanos-Molina, Benoit Mailhot, Maxime Kusik, Dominic Belanger, Martine Lessard, Nicolas Vallières, Xiaoyu Liu, Ning Quan, Steve Lacroix, 2021, 10.21203/rs.3.rs-580331/v1
  • Serial Systemic Injections of Endotoxin (LPS) Elicit Neuroprotective Spinal Cord Microglia through IL-1-Dependent Cross Talk with Endothelial Cells, Camila M. Freria, Faith H. Brennan, David R. Sweet, Zhen Guan, Jodie C. Hall, Kristina A. Kigerl, Daniel P. Nemeth, Xiaoyu Liu, Steve Lacroix, Ning Quan, Phillip G. Popovich, The Journal of Neuroscience, 2020, 10.1523/JNEUROSCI.0131-20.2020
  • Differential attenuation of β2 integrin-dependent and -independent neutrophil migration by Ly6G ligation., , Blood advances, 2019, 10.1182/bloodadvances.2018026732
  • Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury., , Nature communications, 2019, 10.1038/s41467-019-08446-0
  • Portrait of blood-derived extracellular vesicles in patients with Parkinson's disease., , Neurobiology of disease, 2018, 10.1016/j.nbd.2018.11.002
  • FoxJ1 regulates spinal cord development and is required for the maintenance of spinal cord stem cell potential., , Experimental cell research, 2018, 10.1016/j.yexcr.2018.04.017
  • IL-1β enables CNS access to CCR2hi monocytes and the generation of pathogenic cells through GM-CSF released by CNS endothelial cells, Alexandre Paré, Benoit Mailhot, Sébastien A. Lévesque, Camille Juzwik, Prenitha Mercy Ignatius Arokia Doss, Marc-André Lécuyer, Alexandre Prat, Manu Rangachari, Alyson Fournier, Steve Lacroix, Proceedings of the National Academy of Sciences, 2018, 10.1073/pnas.1714948115
  • Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration., , Proceedings of the National Academy of Sciences of the United States of America, 2018, 10.1073/pnas.1720553115
  • Ly6C high monocytes facilitate transport of Murid herpesvirus 68 into inflamed joints of arthritic mice, LeBel, M., Egarnes, B., Brunet, A., Lacerte, P., Paré, A., Lacroix, S., Brown, J.P., Gosselin, J., European Journal of Immunology, 2018, 10.1002/eji.201747048
  • Megakaryocytes compensate for Kit insufficiency in murine arthritis, Pierre Cunin, Loka R. Penke, Jonathan N. Thon, Paul A. Monach, Tatiana Jones, Margaret H. Chang, Mary M. Chen, Imene Melki, Steve Lacroix, Yoichiro Iwakura, Jerry Ware, Michael F. Gurish, Joseph E. Italiano, Eric Boilard, Peter A. Nigrovic, Journal of Clinical Investigation, 2017, 10.1172/JCI84598
  • Betacellulin regulates schwann cell proliferation and myelin formation in the injured mouse peripheral nerve., , Glia, 2017, 10.1002/glia.23119
  • Involvement of the IL-1 system in experimental autoimmune encephalomyelitis and multiple sclerosis: Breaking the vicious cycle between IL-1β and GM-CSF, Alexandre Paré, Benoit Mailhot, Sébastien A. Lévesque, Steve Lacroix, Brain, Behavior, and Immunity, 2016, 10.1016/j.bbi.2016.07.146
  • Myeloid cell transmigration across the CNS vasculature triggers IL-1ß-driven neuroinflammation during autoimmune encephalomyelitis in mice, Lévesque, S.A., Paré, A., Mailhot, B., Bellver-Landete, V., Kébir, H., Lécuyer, M.-A., Alvarez, J.I., Prat, A., de Rivero Vaccari, J.P., Keane, R.W., Lacroix, S., Journal of Experimental Medicine, 2016, 10.1084/jem.20151437
  • The P2X7/P2X4 interaction shapes the purinergic response in murine macrophages, Gabriela Pérez-Flores, Sébastien A. Lévesque, Jonathan Pacheco, Luis Vaca, Steve Lacroix, Patricia Pérez-Cornejo, Jorge Arreola, Biochemical and Biophysical Research Communications, 2015, 10.1016/j.bbrc.2015.10.025
  • GPR84 deficiency reduces microgliosis, but accelerates dendritic degeneration and cognitive decline in a mouse model of Alzheimer’s disease, , Brain, Behavior, and Immunity, 2015, 10.1016/j.bbi.2015.01.010
  • Cerebrovascular and blood-brain barrier impairments in Huntington's disease: Potential implications for its pathophysiology, Drouin-Ouellet, J., Sawiak, S.J., Cisbani, G., Lagacé, M., Kuan, W.-L., Saint-Pierre, M., Dury, R.J., Alata, W., St-Amour, I., Mason, S.L., Calon, F., Lacroix, S., Gowland, P.A., Francis, S.T., Barker, R.A., Cicchetti, F., Annals of Neurology, 2015, 10.1002/ana.24406
  • IL-1α gene deletion protects oligodendrocytes after spinal cord injury through upregulation of the survival factor Tox3, Bastien, D., Landete, V.B., Lessard, M., Vallières, N., Champagne, M., Takashima, A., Tremblay, M.-È., Doyon, Y., Lacroix, S., Journal of Neuroscience, 2015, 10.1523/JNEUROSCI.0498-15.2015
  • In Vivo Imaging of Glial and Immune Cell Responses in Central Nervous System Injury and Disease, Paré, A., Lacroix, S., Neuroinflammation: New Insights into Beneficial and Detrimental Functions, 2015, 10.1002/9781118732748.ch2
  • Partial depletion of the proinflammatory monocyte population is neuroprotective in the myenteric plexus but not in the basal ganglia in a MPTP mouse model of Parkinson's disease, Côté, M., Poirier, A.-A., Aubé, B., Jobin, C., Lacroix, S., Soulet, D., Brain, Behavior, and Immunity, 2015, 10.1016/j.bbi.2015.01.009
  • Central canal ependymal cells proliferate extensively in response to traumatic spinal cord injury but not demyelinating lesions, Lacroix, S., Hamilton, L.K., Vaugeois, A., Beaudoin, S., Breault-Dugas, C., Pineau, I., Lévesque, S.A., Grégoire, C.-A., Fernandes, K.J.L., 2014, 10.1371/journal.pone.0085916
  • Cytokine pathways regulating glial and leukocyte function after spinal cord and peripheral nerve injury, Bastien, D., Lacroix, S., Experimental Neurology, 2014, 10.1016/j.expneurol.2014.04.006
  • Mutant huntingtin is present in neuronal grafts in huntington disease patients, Cicchetti, F., Lacroix, S., Cisbani, G., Vallières, N., Saint-Pierre, M., St-Amour, I., Tolouei, R., Skepper, J.N., Hauser, R.A., Mantovani, D., Barker, R.A., Freeman, T.B., Annals of Neurology, 2014, 10.1002/ana.24174
  • Neutrophils mediate blood-spinal cord barrier disruption in demyelinating neuroinflammatory diseases, Aubé, B., Lévesque, S.A., Paré, A., Chamma, É., Kébir, H., Gorina, R., Lécuyer, M.-A., Alvarez, J.I., De Koninck, Y., Engelhardt, B., Prat, A., Côté, D., Lacroix, S., Journal of Immunology, 2014, 10.4049/jimmunol.1400401
  • Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase a to promote inflammation, Boudreau, L.H., Duchez, A.-C., Cloutier, N., Soulet, D., Martin, N., Bollinger, J., Paré, A., Rousseau, M., Naika, G.S., Lévesque, T., Laflamme, C., Marcoux, G., Lambeau, G., Farndale, R.W., Pouliot, M., Hamzeh-Cognasse, H., Cognasse, F., Garraud, O., Nigrovic, P.A., Guderley, H., Lacroix, S., Thibault, L., Semple, J.W., Gelb, M.H., Boilard, E., Blood, 2014, 10.1182/blood-2014-05-573543
  • The Inflammasome Pyrin Contributes to Pertussis Toxin-Induced IL-1β Synthesis, Neutrophil Intravascular Crawling and Autoimmune Encephalomyelitis, Dumas, A., Amiable, N., de Rivero Vaccari, J.P., Chae, J.J., Keane, R.W., Lacroix, S., Vallières, L., PLoS Pathogens, 2014, 10.1371/journal.ppat.1004150
  • Automated Filtering of Intrinsic Movement Artifacts during Two-Photon Intravital Microscopy, Soulet, D., Paré, A., Coste, J., Lacroix, S., 2013, 10.1371/journal.pone.0053942
  • Local assessment of myelin health in a multiple sclerosis mouse model using a 2D Fourier transform approach, Bégin, S., Bélanger, E., Laffray, S., Aubé, B., Chamma, É., Bélisle, J., Lacroix, S., De Koninck, Y., Côté, D., 2013, 10.1364/BOE.4.002003
  • In situ hybridization within the CNS tissue: Combining in situ hybridization with immunofluorescence, Bastien, D., Lacroix, S., Neuromethods, 2012, 10.1007/978-1-61779-897-9_3
  • P2X 4 receptors influence inflammasome activation after spinal cord injury, de Rivero Vaccari, J.P., Bastien, D., Yurcisin, G., Pineau, I., Dalton Dietrich, W., De Koninck, Y., Keane, R.W., Lacroix, S., 2012, 10.1523/JNEUROSCI.4930-11.2012
  • Platelets can enhance vascular permeability, Cloutier, N., Paré, A., Farndale, R.W., Schumacher, H.R., Nigrovic, P.A., Lacroix, S., Boilard, E., 2012, 10.1182/blood-2012-02-413047
  • Functional recovery after peripheral nerve injury is dependent on the pro-inflammatory cytokines IL-1β and TNF: Implications for neuropathic pain, Nadeau, S., Filali, M., Zhang, J., Kerr, B.J., Rivest, S., Soulet, D., Iwakura, Y., Vaccari, J.P.R., Keane, R.W., Lacroix, S., 2011, 10.1523/JNEUROSCI.2840-11.2011
  • Astrocytes initiate inflammation in the injured mouse spinal cord by promoting the entry of neutrophils and inflammatory monocytes in an IL-1 receptor/MyD88-dependent fashion, Pineau, I., Sun, L., Bastien, D., Lacroix, S., 2010, 10.1016/j.bbi.2009.11.007
  • Transcriptional profiling of the injured sciatic nerve of mice carrying the Wld(S) mutant gene: Identification of genes involved in neuroprotection, neuroinflammation, and nerve regeneration, Barrette, B., Calvo, E., Vallières, N., Lacroix, S., 2010, 10.1016/j.bbi.2010.07.249
  • Endogenous signals initiating inflammation in the injured nervous system, Pineau, I., Lacroix, S., 2009, 10.1002/glia.20763
  • Requirement of myeloid cells for axon regeneration, Barrette, B., Hébert, M.-A., Filali, M., Lafortune, K., Vallières, N., Gowing, G., Julien, J.-P., Lacroix, S., 2008, 10.1523/JNEUROSCI.1447-08.2008
  • Expression profile of receptors for myelin-associated inhibitors of axonal regeneration in the intact and injured mouse central nervous system, Barrette, B., Vallières, N., Dubé, M., Lacroix, S., 2007, 10.1016/j.mcn.2006.12.004
  • Proinflammatory cytokine synthesis in the injured mouse spinal cord: Multiphasic expression pattern and identification of the cell types involved, Pineau, I., Lacroix, S., 2007, 10.1002/cne.21149
  • T cells contribute to lysophosphatidylcholine-induced macrophage activation and demyelination in the CNS, Ghasemlou, N., Suh, Y.J., Lacroix, S., David, S., 2007, 10.1002/glia.20449
  • Toll-like receptor signaling is critical for Wallerian degeneration and functional recovery after peripheral nerve injury, Boivin, A., Pineau, I., Barrette, B., Filali, M., Vallières, N., Rivest, S., Lacroix, S., 2007, 10.1523/JNEUROSCI.3027-07.2007
  • A novel method for multiple labeling combining in situ hybridization with immunofluorescence, Pineau, I., Barrette, B., Vallières, N., Lacroix, S., 2006, 10.1369/jhc.6A7022.2006
  • Systemic injections of lipopolysaccharide accelerates myelin phagocytosis during wallerian degeneration in the injured mouse spinal cord, Vallières, N., Berard, J.L., David, S., Lacroix, S., 2006, 10.1002/glia.20266
  • Involvement of monocyte chemoattractant protein-1, macrophage inflammatory protein-1α and interleukin-1β Wallerian degeneration, Perrin, F.E., Lacroix, S., Avilés-Trieueros, M., David, S., 2005, 10.1093/brain/awh407
  • Bilateral Corticospinal Projections Arise from Each Motor Cortex in the Macaque Monkey: A Quantitative Study, Lacroix, S., Havton, L.A., McKay, H., Yang, H., Brant, A., Roberts, J., Tuszynski, M.H., 2004, 10.1002/cne.20051
  • Molecular approaches to spinal cord repair, David, S., Lacroix, S., 2003, 10.1146/annurev.neuro.26.043002.094946
  • NT-3 gene delivery elicits growth of chronically injured corticospinal axons and modestly improves functional deficits after chronic scar resection, Tuszynski, M.H., Grill, R., Jones, L.L., Brant, A., Blesch, A., Löw, K., Lacroix, S., Lu, P., 2003, 10.1016/S0014-4886(02)00055-9
  • Delivery of hyper-interleukin-6 to the injured spinal cord increases neutrophil and macrophage infiltration and inhibits axonal growth, Lacroix, S., Chang, L., Rose-John, S., Tuszynski, M.H., 2002, 10.1002/cne.10407
  • Proinflammatory signal transduction pathways in the CNS during systemic immune response, Rivest, S., Nadeau, S., Lacroix, S., Laflamme, N., 2001, 10.1016/S1567-7443(01)80015-6
  • How the blood talks to the brain parenchyma and the paraventricular nucleus of the hypothalamus during systemic inflammatory and infectious stimuli, Rivest, S., Lacroix, S., Vallières, L., Nadeau, S., Zhang, J., Laflamme, N., 2000
  • Neurotrophic Factors and Gene Therapy in Spinal Cord Injury, Lacroix, S., Tuszynski, M.H., Neurorehabilitation and Neural Repair, 2000, 10.1177/154596830001400403
  • An essential role of interleukin-1β in mediating NF-κB activity and COX-2 transcription in cells of the blood-brain barrier in response to a systemic and localized inflammation but not during endotoxemia, Laflamme, N., Lacroix, S., Rivest, S., 1999
  • Calretinin gene expression in the human thalamus, Cicchetti, F., Lacroix, S., Beach, T.G., Parent, A., 1998, 10.1016/S0169-328X(97)00314-8
  • Effect of acute systemic inflammatory response and cytokines on the transcription of the genes encoding cyclooxygenase enzymes (COX-1 and COX-2) in the rat brain, Lacroix, S., Rivest, S., 1998
  • The bacterial endotoxin lipopolysaccharide has the ability to target the brain in upregulating its membrane CD14 receptor within specific cellular populations, Lacroix, S., Feinstein, D., Rivest, S., 1998
  • Functional circuitry in the brain of immune-challenged rats: Partial involvement of prostaglandins, Lacroix, S., Rivest, S., 1997, 10.1002/(SICI)1096-9861(19971020)387:2<307::AID-CNE11>3.0.CO;2-R
  • Influence of lnterleukin-6 on neural activity and transcription of the gene encoding corticotrophin-releasing factor in the rat brain: An effect depending upon the route of administration, Vallières, L., Lacroix, S., Rivest, S., 1997, 10.1111/j.1460-9568.1997.tb01500.x
  • C-fos mRNA pattern and corticotropin-releasing factor neuronal activity throughout the brain of rats injected centrally with a prostaglandin of E2 type, Lacroix, S., Vallières, L., Rivest, S., 1996, 10.1016/S0165-5728(96)00114-2
  • Role of cyclo-oxygenase pathways in the stimulatory influence of immune challenge on the transcription of a specific CRF receptor subtype in the rat brain, Lacroix, S., Rivest, S., 1996, 10.1016/0891-0618(95)00106-9
  • Influence of cytokines on neuroendocrine functions during immune response: Mechanisms and neuronal circuitry involved,INFLUENCE DES CYTOKINES SUR LES FONCTIONS NEUROENDOCRINIENNES DURANT LA REPONSE IMMUNITAIRE: MECANISMES IMPLIQUES ET VOIES NEURONALES EMPRUNTEES, Rivest, S., Lacroix, S., Annales d'Endocrinologie, 1995

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Adrian Castellanos Molina - Doctorat - En cours
  • Linda Xiang Wang - Maitrîse avec mémoire - En cours
  • Felipe Da Gama Monteiro - Doctorat - En cours
  • Camille Cassandre Illiano - Doctorat - En cours
  • Victor Bellver Landete - Doctorat - En cours
  • Alexandre Paré - Maitrîse avec mémoire - En cours
  • Maxime Kusik - Maitrîse avec mémoire - En cours
  • Roxanne Turmel - Maitrîse avec mémoire - En cours
  • Juliette Ferry - Doctorat - En cours
  • Benoit Aubé - Maitrîse avec mémoire - 2013/09
  • Marie Rieux - Maitrîse avec mémoire - 2017/01
  • Benoit Mailhot - Maitrîse avec mémoire - 2017/01
  • Floriane Bretheau - Doctorat - 2021/01

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.

Direction et personnes-ressources

Vice-décanat à la recherche et aux études supérieures
Pavillon Ferdinand-Vandry
Université Laval
1050, avenue de la Médecine,  local 4645
Québec, Québec G1V 0A6
Canada

Renseignements - Secrétariat :
vdres@fmed.ulaval.ca

Jacques Simard
Vice-doyen à la recherche et aux études supérieures
vice-doyen.recherche-et-etudes-superieures@fmed.ulaval.ca

Louise Laperrière
Adjointe au vice-doyen à la recherche et aux études supérieures
louise.laperriere@fmed.ulaval.ca 

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