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Stéphane Bolduc

Médecin clinicien enseignant titulaire

Stephane.Bolduc@fmed.ulaval.ca
Centre de recherche sur le cancer
Centre de recherche en organogenèse expérimentale
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Médecine régénératrice et médecine moléculaire
Oncologie
Reproduction, génétique, périnatalité et développement

Domaines et intérêts de recherche du (de la) professeur(e) :

Santé de la mère, des enfants et des adolescents
  • Anomalies congénitales
Cellulaire

Projets de recherche

  • Tissue-Targeted Scaffolds: Integrating Tissue-Specific Biological Cues to Enhance Bioactivity - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2024-04-01 au 2029-03-31
  • Network Affiliated Cancer Centre Agreement - Groupe canadien des essais sur le cancer, chercheur principal - 2022-08-05 au 2027-08-04
  • Tissue-engineered solutions for uro-genital reconstruction, and replacing banned synthetic meshes - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2021-10-01 au 2026-09-30
  • Urogenital tissue engineering solutions for transgender surgeries - Secrétariat des programmes interorganismes à l’intention des établissements - Nouvelles frontières en recherche, chercheur principal - 2024-03-31 au 2026-03-30
  • Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
  • Projet exploratoire où nous voulons introduire des matrices conçues par électrospinning dans nos projets de génies tissulaires urologiques - CHU de Québec – Université Laval – CHUL - Développement de la recherche (FC), chercheur principal - 2022-09-15 au 2024-12-31
  • Alternum optimization and validation to support primary cell growth and advanced 3D model - MITACS Inc. - Accélération Québec (MITACS et gouvernement provincial), chercheur principal - 2024-01-15 au 2024-08-30
  • SOUTIEN AUX ÉTABLISSEMENTS POUR L'IMPLANTATION D'OUTILS COMMUNS EN RECHERCHE CLINIQUE ET POUR LA MISE EN ŒUVRE DU SERVICE D'ÉVALUATION ACCÉLÉRÉE - Catalis, chercheur principal - 2022-02-23 au 2024-06-30
  • Un environnement sécuritaire pour des animaux immunosupprimés - Fondation Canadienne pour l'innovation (La), Centre hospitalier universitaire de Québec - Université Laval, Ministère de la Santé et des Services sociaux - Fonds des leaders John-R.-Evans (FLJR), chercheur principal - 2023-01-01 au 2024-05-24
  • Bisphenol-inducted stromal compartment modifications in bladder cancer using a 3D - Association canadienne d'urologie, chercheur principal - 2023-05-01 au 2024-04-30
  • Salaire d'un professeur - Clinique d'urologie Berger S.E.N.C., chercheur principal - 2015-04-01 au 2022-03-31
  • Génie tissulaire urologique - Fondation du CHU de Québec, chercheur principal - 2019-03-12 au 2020-03-11

Publications

  • Biological Assessment of Zn-Based Absorbable Metals for Ureteral Stent Applications, , Materials (Basel, Switzerland), 2019, 10.3390/ma12203325
  • A Novel and Faster Method to Obtain a Differentiated 3-Dimensional Tissue Engineered Bladder, , The Journal of urology, 2015, 10.1016/j.juro.2015.03.001
  • Genitourinary Tissue Engineering: Reconstruction and Research Models, , Bioengineering (Basel, Switzerland), 2021, 10.3390/bioengineering8070099
  • Factors predicting overall success: a review of 747 microsurgical vasovasostomies, , Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2007, 10.5489/cuaj.454
  • Endocrine-disrupting effects of bisphenols on urological cancers, , Environmental research, 2021, 10.1016/j.envres.2020.110485
  • Adherence to antimuscarinics in children with overactive bladder, , Paediatrics & child health, 2017, 10.1093/pch/pxx055
  • Erratum to: Maintenance of bladder urothelia integrity and successful urothelialization of various tissue-engineered mesenchymes in vitro, , In vitro cellular & developmental biology. Animal, 2015, 10.1007/s11626-015-9955-2
  • Case - Bilateral and recurrent pediatric cystic nephroma associated with DICER1 mutation, , Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2021, 10.5489/cuaj.6836
  • Tissue engineering of a genitourinary tubular tissue graft resistant to suturing and high internal pressures, , Tissue engineering. Part A, 2009, 10.1089/ten.tea.2007.0303
  • Colovaginal fistula: an unusual complication of the tension-free vaginal tape procedure, , The Journal of urology, 2004, 10.1097/01.ju.0000134887.21782.8d
  • Polydimethylsiloxane injection versus open surgery for the treatment of vesicoureteral reflux in complete duplex systems, , The Journal of urology, 2003, 10.1097/01.ju.0000084335.84075.9b
  • Intrascrotal extratesticular schwannoma: A first pediatric case, , Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2014, 10.5489/cuaj.1823
  • Comprehensive overview of the available pharmacotherapy for the treatment of non-neurogenic overactive bladder in children, , Expert opinion on pharmacotherapy, 2022, 10.1080/14656566.2022.2072212
  • Double anticholinergic therapy for refractory neurogenic and nonneurogenic detrusor overactivity in children: Long-term results of a prospective open-label study, , Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2014, 10.5489/cuaj.1362
  • Engineering Tissues without the Use of a Synthetic Scaffold: A Twenty-Year History of the Self-Assembly Method, , BioMed research international, 2018, 10.1155/2018/5684679
  • Demonstration of the direct impact of ketamine on urothelium using a tissue engineered bladder model, , Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2015, 10.5489/cuaj.2899
  • Can we spare removing the adrenal gland at radical nephrectomy in children with wilms tumor?, , The Journal of urology, 2010, 10.1016/j.juro.2010.03.126
  • Learning curve for TIP urethroplasty: A single-surgeon experience, , Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2013, 10.5489/cuaj.1376
  • Novel three-dimensional autologous tissue-engineered vaginal tissues using the self-assembly technique, , Translational research : the journal of laboratory and clinical medicine, 2017, 10.1016/j.trsl.2016.07.019
  • Biological Macromolecule-Based Scaffolds for Urethra Reconstruction, Stéphane Bolduc, Stéphane Chabaud, Mehdi Aleahmad, Mohammad Naji, Mahya Rahmani, Megan Richer, Saeed Farzamfar, Biomolecules, 2023, 10.3390/biom13081167
  • A prospective, multisite study analyzing the percentage of urological cases that can be completely managed by telemedicine, , Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2020, 10.5489/cuaj.6862
  • A rare presentation you want to remember!, , Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2010, 10.5489/cuaj.953
  • Evaluation of a Serum-Free Medium for Human Epithelial and Stromal Cell Culture, , International journal of molecular sciences, 2022, 10.3390/ijms231710035
  • Conditioned medium produced by fibroblasts cultured in low oxygen pressure allows the formation of highly structured capillary-like networks in fibrin gels, , Scientific reports, 2020, 10.1038/s41598-020-66145-z
  • Prevascularized Tissue-Engineered Human Vaginal Mucosa: In Vitro Optimization and In Vivo Validation, , Tissue engineering. Part A, 2020, 10.1089/ten.tea.2020.0036
  • Tissue Engineering in Gynecology, , International journal of molecular sciences, 2022, 10.3390/ijms232012319
  • Allantoic cysts and posterior urethral valves: a case report, , Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 2011, 10.1002/uog.8910
  • Tissue-engineered human 3D model of bladder cancer for invasion study and drug discovery, , Biomaterials, 2017, 10.1016/j.biomaterials.2017.08.041
  • Modeling human bladder cancer, , World journal of urology, 2018, 10.1007/s00345-018-2369-5
  • Maintenance of bladder urothelia integrity and successful urothelialization of various tissue-engineered mesenchymes in vitro, , In vitro cellular & developmental biology. Animal, 2015, 10.1007/s11626-015-9923-x
  • Bisphenol A Alters the Energy Metabolism of Stromal Cells and Could Promote Bladder Cancer Progression, , Cancers, 2021, 10.3390/cancers13215461
  • Prioritization and management recommendations of pediatric urology conditions during the COVID-19 pandemic, , Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2020, 10.5489/cuaj.6693
  • Case - Confirmed testicular mass on ultrasound with no evidence on histology in two teenagers, , Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2020, 10.5489/cuaj.6083
  • Bilateral renal cell carcinoma in a child, , Urology, 2012, 10.1016/j.urology.2012.01.015
  • Lysophosphatidic acid enhances collagen deposition and matrix thickening in engineered tissue, , Journal of tissue engineering and regenerative medicine, 2015, 10.1002/term.1711
  • Bladder substitute reconstructed in a physiological pressure environment, , Journal of pediatric urology, 2011, 10.1016/j.jpurol.2011.03.002
  • Supporting urologists and primary care health providers to provide the best possible patient care: A focus on common pediatric problems, , Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2017
  • Use of a magnetic double J stent in pediatric patients: A case-control study at two Canadian pediatric centers, , Journal of pediatric surgery, 2020, 10.1016/j.jpedsurg.2019.03.014
  • Optimization of the current self-assembled urinary bladder model: Organ-specific stroma and smooth muscle inclusion, , Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2015, 10.5489/cuaj.2953
  • Adipose-derived stromal cells for the reconstruction of a human vesical equivalent, , Journal of tissue engineering and regenerative medicine, 2015, 10.1002/term.1717
  • Hydrophilic-coated catheter appreciation study in a pediatric population, , Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2010, 10.5489/cuaj.09138
  • Urinary PSA: a potential useful marker when serum PSA is between 2.5 ng/mL and 10 ng/mL, , Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2007, 10.5489/cuaj.444
  • Prospective Pilot Study of Mirabegron in Pediatric Patients with Overactive Bladder, , European urology, 2016, 10.1016/j.eururo.2016.02.007
  • Cancer-associated fibroblasts induce epithelial-mesenchymal transition of bladder cancer cells through paracrine IL-6 signalling, , BMC cancer, 2019, 10.1186/s12885-019-5353-6
  • Prospective study using a new bulking agent for the treatment of vesicoureteral reflux: polyacrylamide hydrogel, , The Journal of urology, 2013, 10.1016/j.juro.2013.03.071
  • Perception and satisfaction of patients after telemedicine urology consultations: A matched analysis with physicians' perspective, , Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2022, 10.5489/cuaj.7819
  • Surgical option for the correction of Peyronie's disease: an autologous tissue-engineered endothelialized graft, , The journal of sexual medicine, 2011, 10.1111/j.1743-6109.2011.02374.x
  • Innovative Human Three-Dimensional Tissue-Engineered Models as an Alternative to Animal Testing, , Bioengineering (Basel, Switzerland), 2020, 10.3390/bioengineering7030115
  • Is an initial endoscopic treatment for all ureteroceles appropriate?, , Journal of pediatric urology, 2013, 10.1016/j.jpurol.2012.04.009
  • A rare testicular solid mass in children: Juvenile granulosa cell tumour of testis, , Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2012, 10.5489/cuaj.10176
  • Polyacrylamide Hydrogel as a Bulking Agent for the Endoscopic Treatment of Vesicoureteral Reflux: Long-Term Results and Safety, , The Journal of urology, 2017, 10.1016/j.juro.2016.08.093
  • Collagen hollow structure for bladder tissue engineering, , Materials science & engineering. C, Materials for biological applications, 2019, 10.1016/j.msec.2019.04.052
  • Production of a Self-Aligned Scaffold, Free of Exogenous Material, from Dermal Fibroblasts Using the Self-Assembly Technique, , Dermatology research and practice, 2016, 10.1155/2016/5397319
  • Evaluating the distance travelled for urological pediatric appointments, , Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2019, 10.5489/cuaj.5892
  • First North American experience of propiverine use in children with overactive bladder, , Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2022, 10.5489/cuaj.7811
  • Treatment of vesicoureteral reflux in adults by endoscopic injection, , Urology, 2011, 10.1016/j.urology.2010.12.080
  • Human Organ-Specific 3D Cancer Models Produced by the Stromal Self-Assembly Method of Tissue Engineering for the Study of Solid Tumors, , BioMed research international, 2020, 10.1155/2020/6051210
  • Considerations for the clinical use of stem cells in genitourinary regenerative medicine, , World journal of stem cells, 2021, 10.4252/wjsc.v13.i10.1480
  • Heat-Inactivation of Fetal and Newborn Sera Did Not Impair the Expansion and Scaffold Engineering Potentials of Fibroblasts, , Bioengineering (Basel, Switzerland), 2021, 10.3390/bioengineering8110184
  • Urothelial cell expansion and differentiation are improved by exposure to hypoxia, , Journal of tissue engineering and regenerative medicine, 2017, 10.1002/term.2212
  • Reconstruction of Vascular and Urologic Tubular Grafts by Tissue Engineering, Stéphane Bolduc, Stéphane Chabaud, Christophe Caneparo, Processes, 2021, 10.3390/pr9030513
  • Tissue Engineering for Penile Reconstruction, Stéphane Bolduc, Stéphane Chabaud, Catherine McMartin, Christophe Caneparo, Elissa Elia, Bioengineering, 2024, 10.3390/bioengineering11030230
  • Origin of Serum Affects Quality of Engineered Tissues Produced by the Self-Assembly Approach, , Scientifica, 2016, 10.1155/2016/3825645
  • Tissue Engineering for Gastrointestinal and Genitourinary Tracts, Stéphane Bolduc, Stéphane Chabaud, David Brownell, Elissa Elia, 2022, 10.20944/preprints202211.0261.v1
  • Early detection of prostate cancer local recurrence by urinary prostate-specific antigen, , Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2009, 10.5489/cuaj.1074
  • Bladder cancer cell lines adapt their aggressiveness profile to oxygen tension, , Oncology letters, 2022, 10.3892/ol.2022.13341
  • Prospective study of polydimethylsiloxane vs dextranomer/hyaluronic acid injection for treatment of vesicoureteral reflux, , The Journal of urology, 2014, 10.1016/j.juro.2014.05.116
  • UPEC Colonic-Virulence and Urovirulence Are Blunted by Proanthocyanidins-Rich Cranberry Extract Microbial Metabolites in a Gut Model and a 3D Tissue-Engineered Urothelium, , Microbiology spectrum, 2022, 10.1128/spectrum.02432-21
  • Exosomes Induce Fibroblast Differentiation into Cancer-Associated Fibroblasts through TGFβ Signaling, , Molecular cancer research : MCR, 2018, 10.1158/1541-7786.mcr-17-0784
  • Extracellular Matrix-Based and Electrospun Scaffolding Systems for Vaginal Reconstruction, Stéphane Bolduc, Mohammad Naji, Stéphane Chabaud, Megan Richer, Elissa Elia, Saeed Farzamfar, Bioengineering, 2023, 10.3390/bioengineering10070790
  • Study comparing the applicability of dorsal lumbotomy in older children, , Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2012, 10.5489/cuaj.10064
  • Persistent cloaca and partial caudal duplication: a case report, , Urology, 2011, 10.1016/j.urology.2010.11.010
  • Variation spatiotemporelle de la cryptorchidie et de l'hypospadias au Québec : Une étude exploratoire, , Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2011, 10.5489/cuaj.10090
  • Tissue Engineering in Gynecology, , 2022, 10.20944/preprints202209.0132.v1
  • Bisphenols A and S Alter the Bioenergetics and Behaviours of Normal Urothelial and Bladder Cancer Cells, , Cancers, 2022, 10.3390/cancers14164011
  • Prospective open label study of solifenacin for overactive bladder in children, , The Journal of urology, 2010, 10.1016/j.juro.2010.03.124
  • An endothelialized urothelial cell-seeded tubular graft for urethral replacement, , Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2013, 10.5489/cuaj.12217
  • Long-term use of solifenacin in pediatric patients with overactive bladder: Extension of a prospective open-label study, , Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2014, 10.5489/cuaj.1356
  • Tissue Engineering for Gastrointestinal and Genitourinary Tracts, Stéphane Bolduc, Stéphane Chabaud, David Brownell, Elissa Elia, International Journal of Molecular Sciences, 2022, 10.3390/ijms24010009
  • Inexpensive production of near-native engineered stromas, , Journal of tissue engineering and regenerative medicine, 2017, 10.1002/term.2036
  • Immunocompetent Human 3D Organ-Specific Hormone-Responding Vaginal Mucosa Model of HIV-1 Infection, , Tissue engineering. Part C, Methods, 2021, 10.1089/ten.tec.2020.0333
  • Solifenacin in Children and Adolescents with Overactive Bladder: Results of a Phase 3 Randomised Clinical Trial, , European urology, 2017, 10.1016/j.eururo.2016.08.061
  • Dimercaptosuccinic acid scintigraphy vs. ultrasound for renal parenchymal defects in children, , Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2017, 10.5489/cuaj.4257
  • Double anticholinergic therapy for refractory overactive bladder, , The Journal of urology, 2009, 10.1016/j.juro.2009.05.099
  • Massive hemorrhage from spontaneous rupture of a retroperitoneal lymph node in patient with metastatic mixed germ cell tumor, , Urology, 2010, 10.1016/j.urology.2009.10.001
  • Long-Term Safety and Efficacy of Solifenacin in Children and Adolescents with Overactive Bladder, , The Journal of urology, 2017, 10.1016/j.juro.2017.05.038
  • Dynamic mechanical stimulations induce anisotropy and improve the tensile properties of engineered tissues produced without exogenous scaffolding, , Acta biomaterialia, 2011, 10.1016/j.actbio.2011.05.034
  • Mechanical stimuli-induced urothelial differentiation in a human tissue-engineered tubular genitourinary graft, , European urology, 2011, 10.1016/j.eururo.2011.05.051
  • Anticancer properties of chitosan on human melanoma are cell line dependent, , International journal of biological macromolecules, 2015, 10.1016/j.ijbiomac.2014.08.033
  • A randomized, crossover trial comparing the efficacy and safety of fesoterodine and extended-release oxybutynin in children with overactive bladder with 12-month extension on fesoterodine: The FOXY study, , Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2020, 10.5489/cuaj.6247
  • Organ-specific matrix self-assembled by mesenchymal cells improves the normal urothelial differentiation in vitro, , World journal of urology, 2016, 10.1007/s00345-015-1596-2
  • Glucuronidated Metabolites of Bisphenols A and S Alter the Properties of Normal Urothelial and Bladder Cancer Cells, , International journal of molecular sciences, 2022, 10.3390/ijms232112859
  • Dual Therapy for Refractory Overactive Bladder in Children: A Prospective Open-Label Study, , The Journal of urology, 2017, 10.1016/j.juro.2016.11.101
  • Vesicoureteral reflux: From prophylaxis to surgery, , Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2017, 10.5489/cuaj.4342
  • Clinical challenges in tissue-engineered urethral reconstruction, , Translational andrology and urology, 2016, 10.21037/tau.2016.01.11
  • Modified scrotal (Bianchi) mid raphe single incision orchiopexy for low palpable undescended testis: early outcomes, , The Journal of urology, 2011, 10.1016/j.juro.2010.10.039
  • Anticholinergic use in children: Persistence and patterns of therapy, , Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2016, 10.5489/cuaj.3527
  • In vitro reconstruction of an autologous, watertight, and resistant vesical equivalent, , Tissue engineering. Part A, 2010, 10.1089/ten.tea.2009.0473
  • Efficacy of dextranomer hyaluronic acid and polyacrylamide hydrogel in endoscopic treatment of vesicoureteral reflux: A comparative study, , Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2015, 10.5489/cuaj.2964
  • In vitro reconstruction of a tissue-engineered endothelialized bladder from a single porcine biopsy, , Journal of pediatric urology, 2006, 10.1016/j.jpurol.2005.11.019
  • Overactive bladder in children, , Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2017, 10.5489/cuaj.4337
  • Cancer-Associated Fibroblasts in a 3D Engineered Tissue Model Induce Tumor-like Matrix Stiffening and EMT Transition, , Cancers, 2022, 10.3390/cancers14153810
  • Production of an optimized tissue-engineered pig connective tissue for the reconstruction of the urinary tract, , Tissue engineering. Part A, 2011, 10.1089/ten.tea.2010.0324
  • Prospects and Challenges of Electrospun Cell and Drug Delivery Vehicles to Correct Urethral Stricture, , International journal of molecular sciences, 2022, 10.3390/ijms231810519
  • Tissue engineering of urinary bladder and urethra: advances from bench to patients, , TheScientificWorldJournal, 2013, 10.1155/2013/154564
  • Correlation of vesicoureteral reflux with degree of hydronephrosis and the impact of antireflux surgery, , The Journal of urology, 2003, 10.1097/01.ju.0000084334.10480.88

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Saeed Farzamfar - Post-doctorat - En cours
  • Alexandre Zidat - Maîtrise avec mémoire - En cours
  • Megan Richer - Maîtrise avec mémoire - En cours
  • Félix-Antoine Pellerin - Maîtrise avec mémoire - En cours
  • Elissa Elia - Doctorat - En cours
  • David Brownell - Doctorat - En cours
  • Sara Bouhout - Doctorat - 2015/01
  • Amélie Morissette - Maîtrise avec mémoire - 2015/01
  • Maxime Tondreau - Doctorat - 2015/05
  • Weronika Jakubowska - Maîtrise avec mémoire - 2017/09
  • Devi Paramitha - Maîtrise avec mémoire - 2019/01
  • Cassandra Ringuette Goulet - Doctorat - 2019/01
  • Eve Pellerin - Maîtrise avec mémoire - 2022/09

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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