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Silvia Pozzi
Professeure adjointe
Centre thématique de recherche en neurosciences
Centre de recherche CERVO
Ce profil n’a pas encore été complété.
Contribution à la recherche
Projets de recherche
- Canada Research Chair in Central and Peripheral Cellular Networks in ALS - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2023-02-01 au 2028-01-31
- Unravelling the functions of Peptidyl-Prolyl Isomerase A in axonal transport and neuromuscular junction development and maintenance - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2021-04-01 au 2026-03-31
- Internation Brain Research Organization Award - International Brain Research Organization, chercheur principal - 2022-10-01 au 2024-09-30
- Salaire d'un professeur sous-octroi - CIUSSS - CN - CERVO, chercheur principal - 2021-07-01 au 2024-06-30
- Programme de soutien aux nouveaux chercheurs - Université Laval - Fonds internes - Soutien facultaire aux jeunes chercheurs de la Faculté de médecine, chercheur principal - 2021-07-01 au 2023-06-30
- Unraveling the role of PPIA/EMMPRIN pathway in the communication between Schwann cells and motor neurons in ALS - The Banting research foundation - Discovery Award, chercheur principal - 2022-07-01 au 2023-06-30
- Use of optogenetic-TDP43 to shed light on the dying-back hypothesis in ALS - Université Laval - Fonds internes - BDR - Contributions, chercheur principal - 2022-04-01 au 2023-03-31
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Publications
- Monoclonal full-length antibody against TAR DNA binding protein 43 reduces related proteinopathy in neurons, Silvia Pozzi, Philippe Codron, Geneviève Soucy, Laurence Renaud, Pierre Junior Cordeau, Kallol Dutta, Christine Bareil, Jean-Pierre Julien, JCI Insight, 2020, 10.1172/jci.insight.140420
- Targeting extracellular cyclophilin a reduces neuroinflammation and extends survival in a mouse model of amyotrophic lateral sclerosis, Pasetto, L., Pozzi, S., Castelnovo, M., Basso, M., Estevez, A.G., Fumagalli, S., De Simoni, M.G., Castellaneta, V., Bigini, P., Restelli, E., Chiesa, R., Trojsi, F., Monsurrò, M.R., Callea, L., Malešević, M., Fischer, G., Freschi, M., Tortarolo, M., Bendotti, C., Bonetto, V., Journal of Neuroscience, 2017, 10.1523/JNEUROSCI.2462-16.2016
- Peptidylprolyl isomerase A governs TARDBP function and assembly in heterogeneous nuclear ribonucleoprotein complexes, Lauranzano, E., Pozzi, S., Pasetto, L., Stucchi, R., Massignan, T., Paolella, K., Mombrini, M., Nardo, G., Lunetta, C., Corbo, M., Mora, G., Bendotti, C., Bonetto, V., Brain, 2015, 10.1093/brain/awv005
- Nitroproteomics of peripheral blood mononuclear cells from patients and a rat model of ALS, Nardo, G., Pozzi, S., Mantovani, S., Garbelli, S., Marinou, K., Basso, M., Mora, G., Bendotti, C., Bonetto, V., Antioxidants and Redox Signaling, 2009, 10.1089/ars.2009.2548
- Antibody-Based Therapeutic Interventions for Amyotrophic Lateral Sclerosis: A Systematic Literature Review, , Frontiers in Neuroscience, 2021, 10.3389/fnins.2021.790114
- Virus-mediated delivery of antibody targeting TAR DNA-binding protein-43 mitigates associated neuropathology, Silvia Pozzi, Sai Sampath Thammisetty, Philippe Codron, Reza Rahimian, Karine Valérie Plourde, Geneviève Soucy, Christine Bareil, Daniel Phaneuf, Jasna Kriz, Claude Gravel, Jean-Pierre Julien, Journal of Clinical Investigation, 2019, 10.1172/JCI123931
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A Mouse Model of Familial ALS Has Increased CNS Levels of Endogenous Ubiquinol
9/10 and Does Not Benefit from Exogenous Administration of Ubiquinol10 , Lucchetti, J., Marino, M., Papa, S., Tortarolo, M., Guiso, G., Pozzi, S., Bonetto, V., Caccia, S., Beghi, E., Bendotti, C., Gobbi, M., PLoS ONE, 2013, 10.1371/journal.pone.0069540 - Amyotrophic lateral sclerosis multiprotein biomarkers in peripheral blood mononuclear cells, Nardo, G., Pozzi, S., Pignataro, M., Lauranzano, E., Spano, G., Garbelli, S., Mantovani, S., Marinou, K., Papetti, L., Monteforte, M., Torri, V., Paris, L., Bazzoni, G., Lunetta, C., Corbo, M., Mora, G., Bendotti, C., Bonetto, V., PLoS ONE, 2011, 10.1371/journal.pone.0025545
- Estrogen action in neuroprotection and brain inflammation, Pozzi, S., Benedusi, V., Maggi, A., Vegeto, E., Annals of the New York Academy of Sciences, 2006, 10.1196/annals.1386.035
- Defective cyclophilin A induces TDP-43 proteinopathy: implications for amyotrophic lateral sclerosis and frontotemporal dementia, , Brain, 2021, 10.1093/brain/awab333
- Tryptophan residues in TDP-43 and SOD1 mediate the cross-seeding and toxicity of SOD1, Edward Pokrishevsky, Michèle G. DuVal, Luke McAlary, Sarah Louadi, Silvia Pozzi, Andrei Roman, Steven S Plotkin, Anke Dijkstra, Jean-Pierre Julien, W. Ted Allison, Neil R. Cashman, 2020, 10.1101/2020.07.27.224188
- Cyclophilin A knock-out mice develop a pure frontotemporal dementia phenotype with marked TDP-43 pathology, Pasetto, L., Pozzi, S., Micotti, E., Cerovic, M., Carli, M., Forloni, G., Bonetto, V., bioRxiv, 2020, 10.1101/2020.06.08.129528
- Chronic Administration of Pimozide Fails to Attenuate Motor and Pathological Deficits in Two Mouse Models of Amyotrophic Lateral Sclerosis, Pozzi, S., Thammisetty, S.S., Julien, J.-P., Neurotherapeutics, 2018, 10.1007/s13311-018-0634-3
- Mutant copper-zinc superoxide dismutase (SOD1) induces protein secretion pathway alterations and exosome release in astrocytes: Implications for disease spreading and motor neuron pathology in amyotrophic lateral sclerosis, Basso, M., Pozzi, S., Tortarolo, M., Fiordaliso, F., Bisighini, C., Pasetto, L., Spaltro, G., Lidonnici, D., Gensano, F., Battaglia, E., Bendotti, C., Bonetto, V., Journal of Biological Chemistry, 2013, 10.1074/jbc.M112.425066
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Contribution à l'enseignement aux cycles supérieurs
Étudiant(e)s dirigé(e)s*
Depuis 2009- Shanna Pigeyre - Maîtrise avec mémoire - En cours
- Amélie Poulin-Brière - Maîtrise avec mémoire - En cours
- Marion Boyer - Doctorat - En cours
- Gloria Nwamaka Edozie - Maîtrise avec mémoire - En cours
- Ariane Gosselin - Maîtrise avec mémoire - En cours
- Edris Rezaei - Doctorat - En cours
*Les supervisions d’étudiant(e)s de 1er cycle en
stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées
ultérieurement.