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Serge Rivest

Professeur titulaire

Directeur(trice), Centre de recherche du CHU de Québec - Université Laval

Directeur(trice), Centres de recherche du CHU de Québec - UL

serge.rivest@fmed.ulaval.ca

Site personnel

Département de médecine moléculaire

Centre thématique de recherche en neurosciences

Centre de recherche du CHU de Québec - Université Laval

Centres de recherche du CHU de Québec - UL

Partager la fiche :

Contribution à la recherche

Thématiques de recherche de la Faculté de médecine

Bioinformatique / données massives (big data)
Immunologie-infectiologie
Neurosciences et santé mentale

Projets de recherche en cours

Chaire de recherche du Canada en neuroimmunologie - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2023-07-01 au 2030-06-30
Acquisition d’équipements pour les activités de recherche en oncologie de précision au Nouveau Complexe hospitalier - CHU de Québec – Université Laval – CHUL, Ministère de l'Économie et de l'Innovation - Programme de soutien aux organismes de recherche et d'innovation (PSO) - Volet 4: Soutien au financement d'infrastructures de recherche et d'innovation, chercheur principal - 2022-03-24 au 2027-03-23
Chercheur d'un jour - Conseil de recherches en sciences naturelles et génie Canada - PromoScience, chercheur principal - 2023-01-01 au 2025-12-31

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Financements des 2 dernières années

Therapeutic properties of innate immune cells and system for brain diseases - CHU de Québec – Université Laval – CHUL - Développement de la recherche (FC), chercheur principal - 2022-04-01 au 2025-03-31
Therapeutic properties of innate immune cells and system for brain diseases. - Instituts de recherche en santé du Canada - Subventions Fondation, chercheur principal - 2015-07-01 au 2022-06-30
Programme chercheur-e d'un jour - Fonds de recherche du Québec - Société et culture - Subventions générales de recherche et projets spéciaux (non partageable au prorata), co-chercheur - 2018-04-01 au 2021-03-31
Développement de marqueurs génétiques de maladies rares. - Fondation du CHU de Québec, chercheur principal - 2016-02-11 au 2020-02-10

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Publications

Tissue specificity of SNS response to exercise in mice exposed to low temperatures, , The American journal of physiology, 1992, 10.1152/ajpregu.1992.262.5.R921
Molecular and cellular immune mediators of neuroprotection, , Molecular neurobiology, 2006, 10.1385/MN:34:3:221
A fluorescent probe of polyamine transport accumulates into intracellular acidic vesicles via a two-step mechanism, , The Journal of biological chemistry, 2004, 10.1074/jbc.M401287200
Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease, , Neuron, 2006, 10.1016/j.neuron.2006.01.022
Role of Macrophage Colony-Stimulating Factor Receptor on the Proliferation and Survival of Microglia Following Systemic Nerve and Cuprizone-Induced Injuries, , Frontiers in immunology, 2020, 10.3389/fimmu.2020.00047
In altering the release of glucocorticoids, ketorolac exacerbates the effects of systemic immune stimuli on expression of proinflammatory genes in the brain, , Endocrinology, 2002, 10.1210/en.2002-220598
Corticotropin-releasing factor activates c-fos, NGFI-B, and corticotropin-releasing factor gene expression within the paraventricular nucleus of the rat hypothalamus, , Molecular endocrinology (Baltimore, Md.), 1993, 10.1210/mend.7.10.8264665
Sensorimotor and cognitive functions in a SOD1(G37R) transgenic mouse model of amyotrophic lateral sclerosis, , Behavioural brain research, 2011, 10.1016/j.bbr.2011.07.034
The early contribution of cerebrovascular factors to the pathogenesis of Alzheimer's disease, , The European journal of neuroscience, 2012, 10.1111/j.1460-9568.2012.08126.x
Tumor necrosis factor-alpha and interleukin-1 beta play a critical role in the resistance against lethal herpes simplex virus encephalitis, , The Journal of infectious diseases, 2007, 10.1086/520094
Comparison of the susceptibilities of C57BL/6 and A/J mouse strains to Streptococcus suis serotype 2 infection, , Infection and immunity, 2008, 10.1128/IAI.00350-08
Neuronal activity and neuropeptide gene transcription in the brains of immune-challenged rats, , Journal of neuroendocrinology, 1995, 10.1111/j.1365-2826.1995.tb00788.x
Role of cyclo-oxygenase pathways in the stimulatory influence of immune challenge on the transcription of a specific CRF receptor subtype in the rat brain, , Journal of chemical neuroanatomy, 1996, 10.1016/0891-0618(95)00106-9
Hypothalamic paraventricular nucleus lesions do not prevent anorectic effect of exercise in male rats, , The American journal of physiology, 1990, 10.1152/ajpregu.1990.259.3.R579
Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid beta 1-42 and delay the cognitive decline in a mouse model of Alzheimer's disease, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, 10.1523/JNEUROSCI.1146-08.2008
Chondroitin sulfate proteoglycans in demyelinated lesions impair remyelination, , Annals of neurology, 2012, 10.1002/ana.23599
Regulation of innate immune responses in the brain, , Nature reviews. Immunology, 2009, 10.1038/nri2565
Effect of immobilization stress on transcriptional activity of inducible immediate-early genes, corticotropin-releasing factor, its type 1 receptor, and enkephalin in the hypothalamus of borderline hypertensive rats, , Journal of neurochemistry, 1998, 10.1046/j.1471-4159.1998.70041556.x
Effect of immune and metabolic challenges on the luteinizing hormone-releasing hormone neuronal system in cycling female rats: an evaluation at the transcriptional level, , Endocrinology, 1997, 10.1210/endo.138.4.5044
Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer's disease-related pathology, , Proceedings of the National Academy of Sciences of the United States of America, 2013, 10.1073/pnas.1215165110
Influence of cytokines on neuroendocrine functions during immune response. Mechanisms involved and neuronal pathways, , Annales d'endocrinologie, 1995
The bacterial endotoxin lipopolysaccharide has the ability to target the brain in upregulating its membrane CD14 receptor within specific cellular populations, , Brain pathology (Zurich, Switzerland), 1998, 10.1111/j.1750-3639.1998.tb00189.x
A Ca2+-dependent mechanism of neuronal survival mediated by the microtubule-associated protein p600, , The Journal of biological chemistry, 2013, 10.1074/jbc.M113.483107
Stress-induced genetic expression of a selective corticotropin-releasing factor-receptor subtype within the rat ovaries: an effect dependent on the ovulatory cycle, , Biology of reproduction, 1995, 10.1095/biolreprod53.6.1417
Neuroprotective properties of the innate immune system and bone marrow stem cells in Alzheimer's disease, , Molecular psychiatry, 2006, 10.1038/sj.mp.4001809
Polyamines play a critical role in the control of the innate immune response in the mouse central nervous system, , The Journal of cell biology, 2003, 10.1083/jcb.200301097
L'interleukine-6 dans le système nerveux central, , Medecine sciences : M/S, 2000
Ultrastructural evidence of microglial heterogeneity in Alzheimer's disease amyloid pathology, , Journal of neuroinflammation, 2019, 10.1186/s12974-019-1473-9
Do pathogen exposure and innate immunity cause brain diseases?, , Neurological research, 2005, 10.1179/016164105X49526
The role of microglial cell subsets in Alzheimer's disease, , Current Alzheimer research, 2011, 10.2174/156720511795256035
Mild chronic cerebral hypoperfusion induces neurovascular dysfunction, triggering peripheral beta-amyloid brain entry and aggregation, , Acta neuropathologica communications, 2013, 10.1186/2051-5960-1-75
Triggering of NOD2 Receptor Converts Inflammatory Ly6C into Ly6C Monocytes with Patrolling Properties, , Cell reports, 2017, 10.1016/j.celrep.2017.08.009
The chronic intracerebroventricular infusion of interleukin-1 beta alters the activity of the hypothalamic-pituitary-gonadal axis of cycling rats. I. Effect on LHRH and gonadotropin biosynthesis and secretion, , Endocrinology, 1993, 10.1210/endo.133.6.8243260
Molecular mechanisms and neural pathways mediating the influence of interleukin-1 on the activity of neuroendocrine CRF motoneurons in the rat, , International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1995, 10.1016/0736-5748(94)00063-9
Migration of bone marrow-derived cells into the central nervous system in models of neurodegeneration, , The Journal of comparative neurology, 2013, 10.1002/cne.23363
Corticotropin-releasing hormone and its receptors; an evaluation at the transcription level in vivo, , Peptides, 2001, 10.1016/s0196-9781(01)00389-8
Hematopoietic CC-chemokine receptor 2 (CCR2) competent cells are protective for the cognitive impairments and amyloid pathology in a transgenic mouse model of Alzheimer's disease, , Molecular medicine (Cambridge, Mass.), 2012, 10.2119/molmed.2011.00306
Role of the chemokine receptors CCR2 and CX3CR1 in an experimental model of thrombotic stroke, , Brain, behavior, and immunity, 2018, 10.1016/j.bbi.2018.03.008
Differential effects of central and peripheral injection of interleukin-1 beta on brain c-fos expression and neuroendocrine functions, , Brain research, 1992, 10.1016/0006-8993(92)91424-d
Beneficial Roles of Microglia and Growth Factors in MS, a Brief Review, , Frontiers in cellular neuroscience, 2020, 10.3389/fncel.2020.00284
Whole-exome sequencing identifies homozygous mutation in TTI2 in a child with primary microcephaly: a case report, , BMC neurology, 2020, 10.1186/s12883-020-01643-1
Inflammatory Monocytes and Neutrophils Regulate Streptococcus suis-Induced Systemic Inflammation and Disease but Are Not Critical for the Development of Central Nervous System Disease in a Mouse Model of Infection, , Infection and immunity, 2020, 10.1128/IAI.00787-19
Real-time in vivo imaging reveals the ability of monocytes to clear vascular amyloid beta, , Cell reports, 2013, 10.1016/j.celrep.2013.10.010
Effects of circulating tumor necrosis factor on the neuronal activity and expression of the genes encoding the tumor necrosis factor receptors (p55 and p75) in the rat brain: a view from the blood-brain barrier, , Neuroscience, 1999, 10.1016/s0306-4522(99)00225-0
Neuronal expression of Cd36, Cd44, and Cd83 antigen transcripts maps to distinct and specific murine brain circuits, , The Journal of comparative neurology, 2009, 10.1002/cne.22185
Bone marrow stem cells to the rescue of Alzheimer's disease, , Medecine sciences : M/S, 2006, 10.1051/medsci/20062210822
Hematopoietic MyD88-adaptor protein acts as a natural defense mechanism for cognitive deficits in Alzheimer's disease, , Stem cell reviews and reports, 2012, 10.1007/s12015-012-9356-9
The hematopoietic cytokine M-CSF as a cure for Alzheimer's disease, , Medecine sciences : M/S, 2009, 10.1051/medsci/2009258-9666
Innate Immune Cells: Monocytes, Monocyte-Derived Macrophages and Microglia as Therapeutic Targets for Alzheimer's Disease and Multiple Sclerosis, , Frontiers in cellular neuroscience, 2019, 10.3389/fncel.2019.00355
Microglia, , Current biology : CB, 2008, 10.1016/j.cub.2008.04.047
Boosting regulatory T cells limits neuroinflammation in permanent cortical stroke, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, 10.1523/JNEUROSCI.4901-12.2013
A deficiency in CCR2+ monocytes: the hidden side of Alzheimer's disease, , Journal of molecular cell biology, 2013, 10.1093/jmcb/mjt028
Immune System–Neuroendocrine Interactions, , 2009
Innate immune reaction in response to seizures: implications for the neuropathology associated with epilepsy, , Neurobiology of disease, 2004, 10.1016/j.nbd.2004.03.010
Chondroitin sulfate proteoglycans as novel drivers of leucocyte infiltration in multiple sclerosis, , Brain : a journal of neurology, 2018, 10.1093/brain/awy033
Toll-like receptor 2 signaling in response to brain injury: an innate bridge to neuroinflammation, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, 10.1523/JNEUROSCI.4937-05.2006
Cyclooxygenase 2 (COX-2) inhibition increases the inflammatory response in the brain during systemic immune stimuli, , Journal of neurochemistry, 2005, 10.1111/j.1471-4159.2005.03480.x
Innate immunity in the CNS: redefining the relationship between the CNS and Its environment, , Neuron, 2013, 10.1016/j.neuron.2013.04.005
Role of microglial-derived tumor necrosis factor in mediating CD14 transcription and nuclear factor kappa B activity in the brain during endotoxemia, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000
Effects of systemic immunogenic insults and circulating proinflammatory cytokines on the transcription of the inhibitory factor kappaB alpha within specific cellular populations of the rat brain, , Journal of neurochemistry, 1999, 10.1046/j.1471-4159.1999.0730309.x
A founder mutation in the gene in families from Saguenay-Lac-St-Jean region affected by a pyridoxine-dependent epilepsy, , JIMD reports, 2021, 10.1002/jmd2.12196
Cognitive and non-cognitive behaviors in an APPswe/PS1 bigenic model of Alzheimer's disease, , Genes, brain, and behavior, 2009, 10.1111/j.1601-183X.2008.00453.x
Sub-acute systemic erythropoietin administration reduces ischemic brain injury in an age-dependent manner, , Oncotarget, 2016, 10.18632/oncotarget.9652
Toll-like receptor 4: the missing link of the cerebral innate immune response triggered by circulating gram-negative bacterial cell wall components, , FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2001, 10.1096/fj.00-0339com
Muramyl dipeptide-mediated immunomodulation on monocyte subsets exerts therapeutic effects in a mouse model of Alzheimer's disease, , Journal of neuroinflammation, 2020, 10.1186/s12974-020-01893-3
Effect of exercise training on energy balance of orchidectomized rats, , The American journal of physiology, 1989, 10.1152/ajpregu.1989.257.3.R550
Characterization of the early neuroinflammation after spinal cord injury in mice, , Journal of neuropathology and experimental neurology, 2007, 10.1097/01.jnen.0000248552.07338.7f
mCSF-Induced Microglial Activation Prevents Myelin Loss and Promotes Its Repair in a Mouse Model of Multiple Sclerosis, , Frontiers in cellular neuroscience, 2018, 10.3389/fncel.2018.00178
Interleukin-1 beta inhibits the endogenous expression of the early gene c-fos located within the nucleus of LH-RH neurons and interferes with hypothalamic LH-RH release during proestrus in the rat, , Brain research, 1993, 10.1016/0006-8993(93)90463-w
CRF alters the infundibular LHRH secretory system from the medial preoptic area of female rats: possible involvement of opioid receptors, , Neuroendocrinology, 1993, 10.1159/000126365
Neuroprotective role of the innate immune system by microglia, , Neuroscience, 2007, 10.1016/j.neuroscience.2007.02.055
Tumor necrosis factor alpha but not interleukin 1 beta mediates neuroprotection in response to acute nitric oxide excitotoxicity, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, 10.1523/JNEUROSCI.4032-05.2006
Host immune response to Salmonella enterica serovar Typhimurium infection in mice derived from wild strains, , Infection and immunity, 2002, 10.1128/IAI.70.4.1997-2009.2002
Overproduction of corticotropin-releasing factor in transgenic mice: a genetic model of anxiogenic behavior, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 1994
Neuronal activation of the hypothalamic magnocellular system in response to oropharyngeal stimuli in the rat, , Journal of neuroendocrinology, 1997, 10.1046/j.1365-2826.1997.00573.x
Influence of interleukin-6 on neural activity and transcription of the gene encoding corticotrophin-releasing factor in the rat brain: an effect depending upon the route of administration, , The European journal of neuroscience, 1997, 10.1111/j.1460-9568.1997.tb01500.x
The clinical course of experimental autoimmune encephalomyelitis is associated with a profound and sustained transcriptional activation of the genes encoding toll-like receptor 2 and CD14 in the mouse CNS, , Brain pathology (Zurich, Switzerland), 2002, 10.1111/j.1750-3639.2002.tb00445.x
TREM2 enables amyloid β clearance by microglia, , Cell research, 2015, 10.1038/cr.2015.37
Toll-like receptor-2 deficiency is associated with enhanced brain TNF gene expression during pneumococcal meningitis, , Journal of neuroimmunology, 2005, 10.1016/j.jneuroim.2005.06.016
The 5-hydroxytryptamine agonist fenfluramine increases Fos-like immunoreactivity in the brain, , Brain research, 1992, 10.1016/0006-8993(92)91037-f
Effects of mild chronic cerebral hypoperfusion and early amyloid pathology on spatial learning and the cellular innate immune response in mice, , Neurobiology of aging, 2013, 10.1016/j.neurobiolaging.2012.06.025
The dynamics of monocytes and microglia in Alzheimer's disease, , Alzheimer's research & therapy, 2015, 10.1186/s13195-015-0125-2
Estrogen receptor transrepresses brain inflammation, , Cell, 2011, 10.1016/j.cell.2011.04.018
Anti-inflammatory signaling in microglia exacerbates Alzheimer's disease-related pathology, , Neuron, 2015, 10.1016/j.neuron.2015.01.021
Influence of the paraventricular nucleus of the hypothalamus in the alteration of neuroendocrine functions induced by intermittent footshock or interleukin, , Endocrinology, 1991, 10.1210/endo-129-4-2049
Tissue-Plasminogen Activator Attenuates Alzheimer's Disease-Related Pathology Development in APPswe/PS1 Mice, , Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016, 10.1038/npp.2015.279
C-fos mRNA pattern and corticotropin-releasing factor neuronal activity throughout the brain of rats injected centrally with a prostaglandin of E2 type, , Journal of neuroimmunology, 1996, 10.1016/s0165-5728(96)00114-2
Mechanisms mediating the effects of cytokines on neuroendocrine functions in the rat, , Ciba Foundation symposium, 1993, 10.1002/9780470514368.ch10
Effect of dexfenfluramine on the transcriptional activation of CRF and its type 1 receptor within the paraventricular nucleus of the rat hypothalamus, , British journal of pharmacology, 1996, 10.1111/j.1476-5381.1996.tb16692.x
Central mechanisms and sites of action involved in the inhibitory effects of CRF and cytokines on LHRH neuronal activity, , Annals of the New York Academy of Sciences, 1993, 10.1111/j.1749-6632.1993.tb49928.x
Molecular insights on the cerebral innate immune system, , Brain, behavior, and immunity, 2003, 10.1016/s0889-1591(02)00055-7
GPR84 deficiency reduces microgliosis, but accelerates dendritic degeneration and cognitive decline in a mouse model of Alzheimer's disease, , Brain, behavior, and immunity, 2015, 10.1016/j.bbi.2015.01.010
Arachidonate Metabolites in the Neurophysiological System: The Fever Pathway, , 2004
A central nervous system-restricted isoform of the interleukin-1 receptor accessory protein modulates neuronal responses to interleukin-1, , Immunity, 2009, 10.1016/j.immuni.2009.03.020
Role of the innate immune response in the brain, , Medecine sciences : M/S, 2003, 10.1051/medsci/20031910981
Structural analysis of the microglia-interneuron interactions in the CA1 hippocampal area of the APP/PS1 mouse model of Alzheimer's disease, , The Journal of comparative neurology, 2022, 10.1002/cne.25289
Are glucocorticoids good or bad for brain development and plasticity?, , Endocrinology, 2002, 10.1210/endo.143.4.8800
Cooperation between toll-like receptor 2 and 4 in the brain of mice challenged with cell wall components derived from gram-negative and gram-positive bacteria, , European journal of immunology, 2003, 10.1002/eji.200323821
What is the cellular source of prostaglandins in the brain in response to systemic inflammation? Facts and controversies, , Molecular psychiatry, 1999
Innate immunity: the missing link in neuroprotection and neurodegeneration?, , Nature reviews. Neuroscience, 2002, 10.1038/nrn752
The role of ABCB1 and ABCA1 in beta-amyloid clearance at the neurovascular unit in Alzheimer's disease, , Frontiers in physiology, 2013, 10.3389/fphys.2013.00045
C-C chemokine receptor type 2 (CCR2) signaling protects neonatal male mice with hypoxic-ischemic hippocampal damage from developing spatial learning deficits, , Behavioural brain research, 2015, 10.1016/j.bbr.2015.02.053
Conditional genetic deletion of CSF1 receptor in microglia ameliorates the physiopathology of Alzheimer's disease, , Alzheimer's research & therapy, 2021, 10.1186/s13195-020-00747-7
Early monocyte modulation by the non-erythropoietic peptide ARA 290 decelerates AD-like pathology progression, , Brain, behavior, and immunity, 2022, 10.1016/j.bbi.2021.07.016
Involvement of corticotropin-releasing factor in the anorexia induced by exercise, , Brain research bulletin, 1990, 10.1016/0361-9230(90)90270-a
Circulating cell wall components derived from gram-negative, not gram-positive, bacteria cause a profound induction of the gene-encoding Toll-like receptor 2 in the CNS, , Journal of neurochemistry, 2001, 10.1046/j.1471-4159.2001.00603.x
Patrolling monocytes play a critical role in CX3CR1-mediated neuroprotection during excitotoxicity, , Brain structure & function, 2015, 10.1007/s00429-014-0759-z
The Intellicage system provides a reproducible and standardized method to assess behavioral changes in cuprizone-induced demyelination mouse model, , Behavioural brain research, 2021, 10.1016/j.bbr.2020.113039
Regulation of the genes encoding interleukin-6, its receptor, and gp130 in the rat brain in response to the immune activator lipopolysaccharide and the proinflammatory cytokine interleukin-1beta, , Journal of neurochemistry, 1997, 10.1046/j.1471-4159.1997.69041668.x
PDK4 Inhibition Ameliorates Melatonin Therapy by Modulating Cerebral Metabolism and Remyelination in an EAE Demyelinating Mouse Model of Multiple Sclerosis, , Frontiers in immunology, 2022, 10.3389/fimmu.2022.862316
Cloning of murine TReP-132, a novel transcription factor expressed in brain regions involved in behavioral and psychiatric disorders, , Molecular psychiatry, 2003, 10.1038/sj.mp.4001201
Anti-inflammatory effects of prostaglandin E2 in the central nervous system in response to brain injury and circulating lipopolysaccharide, , Journal of neurochemistry, 2001, 10.1046/j.1471-4159.2001.00080.x
Bone marrow stem cells have the ability to populate the entire central nervous system into fully differentiated parenchymal microglia, , FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004, 10.1096/fj.04-1517fje
PRMT1 is required for the generation of MHC-associated microglia and remyelination in the central nervous system, , Life science alliance, 2022, 10.26508/lsa.202201467
MyD88-deficient bone marrow cells accelerate onset and reduce survival in a mouse model of amyotrophic lateral sclerosis, , The Journal of cell biology, 2007, 10.1083/jcb.200705046
Distribution, regulation and colocalization of the genes encoding the EP2- and EP4-PGE2 receptors in the rat brain and neuronal responses to systemic inflammation, , The European journal of neuroscience, 1999, 10.1046/j.1460-9568.1999.00682.x
Fluoxetine induces the transcription of genes encoding c-fos, corticotropin-releasing factor and its type 1 receptor in rat brain, , Neuroscience, 1998, 10.1016/s0306-4522(98)00147-x
Effects of TNF-alpha and IFN-gamma on nitric oxide-induced neurotoxicity in the mouse brain, , Journal of immunology (Baltimore, Md. : 1950), 2004, 10.4049/jimmunol.172.11.7043
Evidence for a gender-specific protective role of innate immune receptors in a model of perinatal brain injury, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, 10.1523/JNEUROSCI.0535-13.2013
Role of adaptor protein MyD88 in TLR-mediated preconditioning and neuroprotection after acute excitotoxicity, , Brain, behavior, and immunity, 2015, 10.1016/j.bbi.2015.02.019
Peripheral nerve injury alters blood-spinal cord barrier functional and molecular integrity through a selective inflammatory pathway, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, 10.1523/JNEUROSCI.1642-11.2011
Getting Too Old Too Quickly for Their Job: Senescent Glial Cells Promote Neurodegeneration, , Neuron, 2018, 10.1016/j.neuron.2018.11.006
How do immune cells support and shape the brain in health, disease, and aging?, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, 10.1523/JNEUROSCI.3241-13.2013
Correction to: Selective Immunomodulatory and Neuroprotective Effects of a NOD2 Receptor Agonist on Mouse Models of Multiple Sclerosis, , Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2021, 10.1007/s13311-021-01035-4
Triggering Innate Immune Receptors as New Therapies in Alzheimer's Disease and Multiple Sclerosis, , Cells, 2021, 10.3390/cells10082164
Selective Immunomodulatory and Neuroprotective Effects of a NOD2 Receptor Agonist on Mouse Models of Multiple Sclerosis, , Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2021, 10.1007/s13311-020-00998-0
Effects of exercise on energy balance in meal-fed mice, , Physiology & behavior, 1991, 10.1016/0031-9384(91)90043-n
Immune mechanisms underlying the beneficial effects of autologous hematopoietic stem cell transplantation in multiple sclerosis, , Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2011, 10.1007/s13311-011-0062-0
The impact of Ly6Clow monocytes after cerebral hypoxia-ischemia in adult mice, , Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, 10.1038/jcbfm.2014.80
Alcohol-induced inhibition of LH secretion in intact and gonadectomized male and female rats: possible mechanisms, , Alcoholism, clinical and experimental research, 1992, 10.1111/j.1530-0277.1992.tb01896.x
Lesions of hypothalamic PVN partially attenuate stimulatory action of alcohol on ACTH secretion in rats, , The American journal of physiology, 1994, 10.1152/ajpregu.1994.266.2.R553
Reduced Melatonin Levels May Facilitate Glioblastoma Initiation in the Subventricular Zone, , Expert reviews in molecular medicine, 2022, 10.1017/erm.2022.15
Is survival possible without arachidonate metabolites in the brain during systemic infection?, , News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society, 2003, 10.1152/nips.01415.2002
Selective involvement of interleukin-6 in the transcriptional activation of the suppressor of cytokine signaling-3 in the brain during systemic immune challenges, , Endocrinology, 2000, 10.1210/endo.141.10.7695
Bone Marrow Chimeras to Study Neuroinflammation, , Current protocols in immunology, 2018, 10.1002/cpim.56
Blood-nerve barrier dysfunction contributes to the generation of neuropathic pain and allows targeting of injured nerves for pain relief, , Pain, 2014, 10.1016/j.pain.2014.01.026
Chemokine expression by glial cells directs leukocytes to sites of axonal injury in the CNS, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003
Lack of gestation-related changes of urocortin gene expression in human placenta, , Prenatal and neonatal medicine : the international journal of basic and clinical research and practice, 1999
MyD88-adaptor protein acts as a preventive mechanism for memory deficits in a mouse model of Alzheimer's disease, , Molecular neurodegeneration, 2011, 10.1186/1750-1326-6-5
A Homozygous Deep Intronic Mutation Alters the Splicing of Nebulin Gene in a Patient With Nemaline Myopathy, , Frontiers in neurology, 2021, 10.3389/fneur.2021.660113
Bone marrow-derived macrophages and the CNS: An update on the use of experimental chimeric mouse models and bone marrow transplantation in neurological disorders, , Biochimica et biophysica acta, 2016, 10.1016/j.bbadis.2015.09.017
Immune challenge and immobilization stress induce transcription of the gene encoding the CRF receptor in selective nuclei of the rat hypothalamus, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 1995
Interleukin-6 is a needed proinflammatory cytokine in the prolonged neural activity and transcriptional activation of corticotropin-releasing factor during endotoxemia, , Endocrinology, 1999, 10.1210/endo.140.9.6983
The HPA - Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain, , Frontiers in immunology, 2014, 10.3389/fimmu.2014.00136
The promise of anti-inflammatory therapies for CNS injuries and diseases, , Expert review of neurotherapeutics, 2011, 10.1586/ern.11.64
Adrenalectomy attenuates the effect of chemical castration on energy balance in rats, , The Journal of nutrition, 1992, 10.1093/jn/122.2.369
Influence of the estrous cycle on c-fos and CRH gene transcription in the brain of endotoxin-challenged female rats, , Neuroendocrinology, 1997, 10.1159/000127162
Alzheimer's disease: microglia targets and their modulation to promote amyloid phagocytosis and mitigate neuroinflammation, , Expert opinion on therapeutic targets, 2020, 10.1080/14728222.2020.1738391
Microglia Purinoceptor P2Y6: An Emerging Therapeutic Target in CNS Diseases, , Cells, 2020, 10.3390/cells9071595
Immunotherapy for neurological diseases, , Clinical immunology (Orlando, Fla.), 2008, 10.1016/j.clim.2008.04.003
Glucocorticoids: protectors of the brain during innate immune responses, , The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2004, 10.1177/1073858404263494
Context-dependent transcriptional regulation of microglial proliferation, , Glia, 2022, 10.1002/glia.24124
Toll-like receptor signaling is critical for Wallerian degeneration and functional recovery after peripheral nerve injury, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, 10.1523/JNEUROSCI.3027-07.2007
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Intranasal herpes simplex virus type 2 inoculation causes a profound thymidine kinase dependent cerebral inflammatory response in the mouse hindbrain, , The European journal of neuroscience, 2002, 10.1046/j.1460-9568.2002.02057.x
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Targeting innate immunity to protect and cure Alzheimer's disease: opportunities and pitfalls, , Molecular psychiatry, 2021, 10.1038/s41380-021-01083-4
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Multifocal Cerebral Microinfarcts Modulate Early Alzheimer's Disease Pathology in a Sex-Dependent Manner, , Frontiers in immunology, 2021, 10.3389/fimmu.2021.813536
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Shehata Ibrahim Anwar Shehata - Post-doctorat - En cours
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