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Serge Rivest

Professeur titulaire

Directeur(trice), Centre de recherche du CHU de Québec - Université Laval

Directeur(trice), Centres de recherche du CHU de Québec - UL

Serge Rivest
serge.rivest@fmed.ulaval.ca
Centre thématique de recherche en neurosciences
Centre de recherche du CHU de Québec - Université Laval
Centres de recherche du CHU de Québec - UL
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Bioinformatique / données massives (big data)
Immunologie-infectiologie
Neurosciences et santé mentale

Domaines et intérêts de recherche du (de la) professeur(e) :

Maladies infectieuses et immunitaires
  • Développement de vaccins
  • Immunothérapie
  • Maladies auto-immunes
  • Système immunitaire
Neurosciences, santé mentale et toxicomanies
  • Démences
  • Maladie d'Alzheimer
  • Maladies neurodégénératives
  • Maladies neuroimmunologiques
  • Sclérose en plaques
Vieillissement
  • Dégénérescence cellulaire
  • Vieillissement cellulaire

Projets de recherche

  • Chaire de recherche du Canada en neuroimmunologie - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2023-07-01 au 2030-06-30
  • Acquisition d’équipements pour les activités de recherche en oncologie de précision au Nouveau Complexe hospitalier - CHU de Québec – Université Laval – CHUL, Ministère de l'Économie et de l'Innovation - Programme de soutien aux organismes de recherche et d'innovation (PSO) - Volet 4: Soutien au financement d'infrastructures de recherche et d'innovation, chercheur principal - 2022-03-24 au 2027-03-23
  • Chercheur d'un jour - Conseil de recherches en sciences naturelles et génie Canada - PromoScience, chercheur principal - 2023-01-01 au 2025-12-31
  • Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
  • Therapeutic properties of innate immune cells and system for brain diseases - CHU de Québec – Université Laval – CHUL - Développement de la recherche (FC), chercheur principal - 2022-04-01 au 2025-03-31
  • Chaire de recherche du Canada en neuroimmunologie - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2016-07-01 au 2023-06-30
  • Chercheur d'un jour - Conseil de recherches en sciences naturelles et génie Canada - PromoScience, chercheur principal - 2021-01-01 au 2022-12-31
  • Therapeutic properties of innate immune cells and system for brain diseases. - Instituts de recherche en santé du Canada - Subventions Fondation, chercheur principal - 2015-07-01 au 2022-06-30
  • Développement de marqueurs génétiques de maladies rares. - Fondation du CHU de Québec, chercheur principal - 2016-02-11 au 2020-02-10

Publications

  • Anti-inflammatory signaling in microglia exacerbates Alzheimer's disease-related pathology, , Neuron, 2015, 10.1016/j.neuron.2015.01.021
  • Adrenalectomy attenuates the effect of chemical castration on energy balance in rats, , The Journal of nutrition, 1992, 10.1093/jn/122.2.369
  • Powerful beneficial effects of macrophage colony-stimulating factor on beta-amyloid deposition and cognitive impairment in Alzheimer's disease, , Brain : a journal of neurology, 2009, 10.1093/brain/awn331
  • Molecular mechanisms and neural pathways mediating the influence of interleukin-1 on the activity of neuroendocrine CRF motoneurons in the rat, , International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1995, 10.1016/0736-5748(94)00063-9
  • Immune mechanisms underlying the beneficial effects of autologous hematopoietic stem cell transplantation in multiple sclerosis, , Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2011, 10.1007/s13311-011-0062-0
  • Cannabinoids in microglia: a new trick for immune surveillance and neuroprotection, , Neuron, 2006, 10.1016/j.neuron.2005.12.004
  • Influence of interleukin-6 on neural activity and transcription of the gene encoding corticotrophin-releasing factor in the rat brain: an effect depending upon the route of administration, , The European journal of neuroscience, 1997, 10.1111/j.1460-9568.1997.tb01500.x
  • The LPS receptor (CD14) links innate immunity with Alzheimer's disease, , FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004, 10.1096/fj.03-0364fje
  • Expression and neuropeptidergic characterization of estrogen receptors (ERalpha and ERbeta) throughout the rat brain: anatomical evidence of distinct roles of each subtype, , Journal of neurobiology, 1998, 10.1002/(sici)1097-4695(19980905)36:33.0.co;2-v
  • Streptococcus suis serotype 2, an important swine and human pathogen, induces strong systemic and cerebral inflammatory responses in a mouse model of infection, , Journal of immunology (Baltimore, Md. : 1950), 2007, 10.4049/jimmunol.179.3.1842
  • Targeting innate immunity to protect and cure Alzheimer's disease: opportunities and pitfalls, , Molecular psychiatry, 2021, 10.1038/s41380-021-01083-4
  • Lipid metabolism and neuroinflammation in Alzheimer's disease: a role for liver X receptors, , Endocrine reviews, 2012, 10.1210/er.2011-1049
  • Expression of CCR2 in both resident and bone marrow-derived microglia plays a critical role in neuropathic pain, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, 10.1523/JNEUROSCI.3016-07.2007
  • Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid beta 1-42 and delay the cognitive decline in a mouse model of Alzheimer's disease, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, 10.1523/JNEUROSCI.1146-08.2008
  • Impact of deficiency in CCR2 and CX3CR1 receptors on monocytes trafficking in herpes simplex virus encephalitis, , The Journal of general virology, 2012, 10.1099/vir.0.041046-0
  • Polyamines play a critical role in the control of the innate immune response in the mouse central nervous system, , The Journal of cell biology, 2003, 10.1083/jcb.200301097
  • Effects of mild chronic cerebral hypoperfusion and early amyloid pathology on spatial learning and the cellular innate immune response in mice, , Neurobiology of aging, 2013, 10.1016/j.neurobiolaging.2012.06.025
  • Muramyl dipeptide-mediated immunomodulation on monocyte subsets exerts therapeutic effects in a mouse model of Alzheimer's disease, , Journal of neuroinflammation, 2020, 10.1186/s12974-020-01893-3
  • The promise of anti-inflammatory therapies for CNS injuries and diseases, , Expert review of neurotherapeutics, 2011, 10.1586/ern.11.64
  • Intranasal herpes simplex virus type 2 inoculation causes a profound thymidine kinase dependent cerebral inflammatory response in the mouse hindbrain, , The European journal of neuroscience, 2002, 10.1046/j.1460-9568.2002.02057.x
  • Oncostatin M is a novel glucocorticoid-dependent neuroinflammatory factor that enhances oligodendrocyte precursor cell activity in demyelinated sites, , Brain, behavior, and immunity, 2010, 10.1016/j.bbi.2010.01.005
  • The clinical course of experimental autoimmune encephalomyelitis is associated with a profound and sustained transcriptional activation of the genes encoding toll-like receptor 2 and CD14 in the mouse CNS, , Brain pathology (Zurich, Switzerland), 2002, 10.1111/j.1750-3639.2002.tb00445.x
  • Corticotropin-releasing factor (CRF) and stress-related reproductive failure: the brain as a state of the art or the ovary as a novel clue?, , Journal of endocrinological investigation, 1995, 10.1007/BF03349836
  • Triggering Innate Immune Receptors as New Therapies in Alzheimer's Disease and Multiple Sclerosis, , Cells, 2021, 10.3390/cells10082164
  • Toll-like receptor 2-independent and MyD88-dependent gene expression in the mouse brain, , Journal of innate immunity, 2009, 10.1159/000225990
  • Cognitive and non-cognitive behaviors in an APPswe/PS1 bigenic model of Alzheimer's disease, , Genes, brain, and behavior, 2009, 10.1111/j.1601-183X.2008.00453.x
  • MyD88-deficient bone marrow cells accelerate onset and reduce survival in a mouse model of amyotrophic lateral sclerosis, , The Journal of cell biology, 2007, 10.1083/jcb.200705046
  • Neuronal expression of Cd36, Cd44, and Cd83 antigen transcripts maps to distinct and specific murine brain circuits, , The Journal of comparative neurology, 2009, 10.1002/cne.22185
  • Reversible increase in energy deposition following castration induced by a gonadotropin releasing hormone agonist, , International journal of obesity, 1991
  • An essential role of interleukin-1beta in mediating NF-kappaB activity and COX-2 transcription in cells of the blood-brain barrier in response to a systemic and localized inflammation but not during endotoxemia, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999
  • The bacterial endotoxin lipopolysaccharide has the ability to target the brain in upregulating its membrane CD14 receptor within specific cellular populations, , Brain pathology (Zurich, Switzerland), 1998, 10.1111/j.1750-3639.1998.tb00189.x
  • A founder mutation in the gene in families from Saguenay-Lac-St-Jean region affected by a pyridoxine-dependent epilepsy, , JIMD reports, 2021, 10.1002/jmd2.12196
  • Migration of bone marrow-derived cells into the central nervous system in models of neurodegeneration, , The Journal of comparative neurology, 2013, 10.1002/cne.23363
  • Immune Function and Regulation of the Autonomic Nervous System: A Molecular Point of View, , 2003
  • Arachidonate Metabolites in the Neurophysiological System: The Fever Pathway, , 2004
  • The impact of Ly6Clow monocytes after cerebral hypoxia-ischemia in adult mice, , Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, 10.1038/jcbfm.2014.80
  • Influence of the paraventricular nucleus of the hypothalamus in the alteration of neuroendocrine functions induced by intermittent footshock or interleukin, , Endocrinology, 1991, 10.1210/endo-129-4-2049
  • Effect of a chronic stress on CRF neuronal activity and expression of its type 1 receptor in the rat brain, , The American journal of physiology, 1998, 10.1152/ajpregu.1998.275.5.R1438
  • Corticotropin-releasing factor and glucocorticoid receptor (GR) gene expression in the paraventricular nucleus of immune-challenged transgenic mice expressing type II GR antisense ribonucleic acid, , Journal of molecular neuroscience : MN, 1997, 10.1007/BF02736831
  • Cyclooxygenase 2 (COX-2) inhibition increases the inflammatory response in the brain during systemic immune stimuli, , Journal of neurochemistry, 2005, 10.1111/j.1471-4159.2005.03480.x
  • The role of pericytes in neurovascular unit remodeling in brain disorders, , International journal of molecular sciences, 2014, 10.3390/ijms15046453
  • The neuroendocrine control of the innate immune system in health and brain diseases, , Immunological reviews, 2012, 10.1111/j.1600-065X.2012.01129.x
  • Effects of corticotropin-releasing factor on energy balance in rats are sex dependent, , The American journal of physiology, 1989, 10.1152/ajpregu.1989.257.6.R1417
  • mCSF-Induced Microglial Activation Prevents Myelin Loss and Promotes Its Repair in a Mouse Model of Multiple Sclerosis, , Frontiers in cellular neuroscience, 2018, 10.3389/fncel.2018.00178
  • A 'don't eat me' immune signal protects neuronal connections, , Nature, 2018, 10.1038/d41586-018-07165-8
  • Delayed but not early glucocorticoid treatment protects the host during experimental herpes simplex virus encephalitis in mice, , The Journal of infectious diseases, 2007, 10.1086/511987
  • Innate immune receptor expression in normal brain aging, , Neuroscience, 2007, 10.1016/j.neuroscience.2007.01.004
  • A Ca2+-dependent mechanism of neuronal survival mediated by the microtubule-associated protein p600, , The Journal of biological chemistry, 2013, 10.1074/jbc.M113.483107
  • The dynamics of monocytes and microglia in Alzheimer's disease, , Alzheimer's research & therapy, 2015, 10.1186/s13195-015-0125-2
  • Immune challenge and immobilization stress induce transcription of the gene encoding the CRF receptor in selective nuclei of the rat hypothalamus, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 1995
  • Structural analysis of the microglia-interneuron interactions in the CA1 hippocampal area of the APP/PS1 mouse model of Alzheimer's disease, , The Journal of comparative neurology, 2022, 10.1002/cne.25289
  • Functional recovery after peripheral nerve injury is dependent on the pro-inflammatory cytokines IL-1β and TNF: implications for neuropathic pain, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, 10.1523/JNEUROSCI.2840-11.2011
  • Correction to: Selective Immunomodulatory and Neuroprotective Effects of a NOD2 Receptor Agonist on Mouse Models of Multiple Sclerosis, , Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2021, 10.1007/s13311-021-01035-4
  • Age-related changes in synaptic markers and monocyte subsets link the cognitive decline of APP(Swe)/PS1 mice, , Frontiers in cellular neuroscience, 2012, 10.3389/fncel.2012.00051
  • Perspective: how to make microarray, serial analysis of gene expression, and proteomic relevant to day-to-day endocrine problems and physiological systems, , Endocrinology, 2002, 10.1210/endo.143.6.8868
  • Microglia Purinoceptor P2Y6: An Emerging Therapeutic Target in CNS Diseases, , Cells, 2020, 10.3390/cells9071595
  • Bone marrow stem cells have the ability to populate the entire central nervous system into fully differentiated parenchymal microglia, , FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004, 10.1096/fj.04-1517fje
  • High fat diet exacerbates Alzheimer's disease-related pathology in APPswe/PS1 mice, , Oncotarget, 2016, 10.18632/oncotarget.12179
  • Case Report: Two Families With HPDL Related Neurodegeneration, , Frontiers in genetics, 2022, 10.3389/fgene.2022.780764
  • Severe chronic cerebral hypoperfusion induces microglial dysfunction leading to memory loss in APPswe/PS1 mice, , Oncotarget, 2016, 10.18632/oncotarget.7689
  • Involvement of corticotropin-releasing factor in the anorexia induced by exercise, , Brain research bulletin, 1990, 10.1016/0361-9230(90)90270-a
  • The role of exercise in thermogenesis and energy balance, , Canadian journal of physiology and pharmacology, 1989, 10.1139/y89-064
  • The combination of valacyclovir with an anti-TNF alpha antibody increases survival rate compared to antiviral therapy alone in a murine model of herpes simplex virus encephalitis, , Antiviral research, 2013, 10.1016/j.antiviral.2013.10.007
  • Corticotropin-releasing hormone and its receptors; an evaluation at the transcription level in vivo, , Peptides, 2001, 10.1016/s0196-9781(01)00389-8
  • In altering the release of glucocorticoids, ketorolac exacerbates the effects of systemic immune stimuli on expression of proinflammatory genes in the brain, , Endocrinology, 2002, 10.1210/en.2002-220598
  • Role of IL-1 and TNF in the brain: twenty years of progress on a Dr. Jekyll/Mr. Hyde duality of the innate immune system, , Brain, behavior, and immunity, 2007, 10.1016/j.bbi.2006.12.004
  • Anti-inflammatory effects of prostaglandin E2 in the central nervous system in response to brain injury and circulating lipopolysaccharide, , Journal of neurochemistry, 2001, 10.1046/j.1471-4159.2001.00080.x
  • A fluorescent probe of polyamine transport accumulates into intracellular acidic vesicles via a two-step mechanism, , The Journal of biological chemistry, 2004, 10.1074/jbc.M401287200
  • Are glucocorticoids good or bad for brain development and plasticity?, , Endocrinology, 2002, 10.1210/endo.143.4.8800
  • Bone Marrow Chimeras to Study Neuroinflammation, , Current protocols in immunology, 2018, 10.1002/cpim.56
  • How the blood talks to the brain parenchyma and the paraventricular nucleus of the hypothalamus during systemic inflammatory and infectious stimuli, , Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 2000, 10.1046/j.1525-1373.2000.22304.x
  • MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1, , The Journal of biological chemistry, 2009, 10.1074/jbc.M807530200
  • Neuronal activation of the hypothalamic magnocellular system in response to oropharyngeal stimuli in the rat, , Journal of neuroendocrinology, 1997, 10.1046/j.1365-2826.1997.00573.x
  • How do immune cells support and shape the brain in health, disease, and aging?, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, 10.1523/JNEUROSCI.3241-13.2013
  • Is survival possible without arachidonate metabolites in the brain during systemic infection?, , News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society, 2003, 10.1152/nips.01415.2002
  • A deficiency in CCR2+ monocytes: the hidden side of Alzheimer's disease, , Journal of molecular cell biology, 2013, 10.1093/jmcb/mjt028
  • Evidence for a gender-specific protective role of innate immune receptors in a model of perinatal brain injury, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, 10.1523/JNEUROSCI.0535-13.2013
  • Hypothalamic paraventricular nucleus lesions do not prevent anorectic effect of exercise in male rats, , The American journal of physiology, 1990, 10.1152/ajpregu.1990.259.3.R579
  • Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke, , Nature medicine, 2009, 10.1038/nm.1927
  • Regulation of the Leishmania-induced innate inflammatory response by the protein tyrosine phosphatase SHP-1, , European journal of immunology, 2005, 10.1002/eji.200526037
  • Expression of corticotropin-releasing factor and its receptors in the brain of lean and obese Zucker rats, , Endocrinology, 1996, 10.1210/endo.137.11.8895348
  • Effect of stress on the activity of the hypothalamic-pituitary-gonadal axis: peripheral and central mechanisms, , Biology of reproduction, 1991, 10.1095/biolreprod45.4.523
  • Glucocorticoids: protectors of the brain during innate immune responses, , The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2004, 10.1177/1073858404263494
  • Comparison of the susceptibilities of C57BL/6 and A/J mouse strains to Streptococcus suis serotype 2 infection, , Infection and immunity, 2008, 10.1128/IAI.00350-08
  • Role of cyclo-oxygenase pathways in the stimulatory influence of immune challenge on the transcription of a specific CRF receptor subtype in the rat brain, , Journal of chemical neuroanatomy, 1996, 10.1016/0891-0618(95)00106-9
  • The HPA - Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain, , Frontiers in immunology, 2014, 10.3389/fimmu.2014.00136
  • Role of microglial-derived tumor necrosis factor in mediating CD14 transcription and nuclear factor kappa B activity in the brain during endotoxemia, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000
  • Innate immunity in the CNS: redefining the relationship between the CNS and Its environment, , Neuron, 2013, 10.1016/j.neuron.2013.04.005
  • An elevated matrix metalloproteinase (MMP) in an animal model of multiple sclerosis is protective by affecting Th1/Th2 polarization, , FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2005, 10.1096/fj.04-2030fje
  • Toll-like receptor signaling is critical for Wallerian degeneration and functional recovery after peripheral nerve injury, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, 10.1523/JNEUROSCI.3027-07.2007
  • Proinflammatory signal transduction pathways in the CNS during systemic immune response, , 2001
  • Neuroprotective role of the innate immune system by microglia, , Neuroscience, 2007, 10.1016/j.neuroscience.2007.02.055
  • Whole-exome sequencing identifies homozygous mutation in TTI2 in a child with primary microcephaly: a case report, , BMC neurology, 2020, 10.1186/s12883-020-01643-1
  • Tissue specificity of SNS response to exercise in mice exposed to low temperatures, , The American journal of physiology, 1992, 10.1152/ajpregu.1992.262.5.R921
  • Tumor necrosis factor alpha but not interleukin 1 beta mediates neuroprotection in response to acute nitric oxide excitotoxicity, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, 10.1523/JNEUROSCI.4032-05.2006
  • Targeting Systemic Innate Immune Cells as a Therapeutic Avenue for Alzheimer Disease, , Pharmacological reviews, 2022, 10.1124/pharmrev.121.000400
  • Glucocorticoids play a fundamental role in protecting the brain during innate immune response, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003
  • Involvement of serotonergic pathways in mediating the neuronal activity and genetic transcription of neuroendocrine corticotropin-releasing factor in the brain of systemically endotoxin-challenged rats, , Neuroscience, 1999, 10.1016/s0306-4522(98)00369-8
  • Innate immunity: the missing link in neuroprotection and neurodegeneration?, , Nature reviews. Neuroscience, 2002, 10.1038/nrn752
  • Alzheimer's disease: microglia targets and their modulation to promote amyloid phagocytosis and mitigate neuroinflammation, , Expert opinion on therapeutic targets, 2020, 10.1080/14728222.2020.1738391
  • Central nervous system-initiated inflammation and neurotrophism in trauma: IL-1 beta is required for the production of ciliary neurotrophic factor, , Journal of immunology (Baltimore, Md. : 1950), 2000, 10.4049/jimmunol.165.4.2232
  • Selective involvement of interleukin-6 in the transcriptional activation of the suppressor of cytokine signaling-3 in the brain during systemic immune challenges, , Endocrinology, 2000, 10.1210/endo.141.10.7695
  • C-C chemokine receptor type 2 (CCR2) signaling protects neonatal male mice with hypoxic-ischemic hippocampal damage from developing spatial learning deficits, , Behavioural brain research, 2015, 10.1016/j.bbr.2015.02.053
  • Estrogen receptor transrepresses brain inflammation, , Cell, 2011, 10.1016/j.cell.2011.04.018
  • Luteinizing hormone secretion and corticotropin-releasing factor gene expression in the paraventricular nucleus of rhesus monkeys following cortisol synthesis inhibition, , Endocrinology, 1997, 10.1210/endo.138.6.5171
  • Effect of exercise training on energy balance of orchidectomized rats, , The American journal of physiology, 1989, 10.1152/ajpregu.1989.257.3.R550
  • Microglia, , Current biology : CB, 2008, 10.1016/j.cub.2008.04.047
  • Interleukin-1 beta inhibits the endogenous expression of the early gene c-fos located within the nucleus of LH-RH neurons and interferes with hypothalamic LH-RH release during proestrus in the rat, , Brain research, 1993, 10.1016/0006-8993(93)90463-w
  • New Therapeutic Avenues of mCSF for Brain Diseases and Injuries, , Frontiers in cellular neuroscience, 2018, 10.3389/fncel.2018.00499
  • Molecular and cellular immune mediators of neuroprotection, , Molecular neurobiology, 2006, 10.1385/MN:34:3:221
  • Innate immune reaction in response to seizures: implications for the neuropathology associated with epilepsy, , Neurobiology of disease, 2004, 10.1016/j.nbd.2004.03.010
  • MyD88-adaptor protein acts as a preventive mechanism for memory deficits in a mouse model of Alzheimer's disease, , Molecular neurodegeneration, 2011, 10.1186/1750-1326-6-5
  • Neuronal activity and neuropeptide gene transcription in the brains of immune-challenged rats, , Journal of neuroendocrinology, 1995, 10.1111/j.1365-2826.1995.tb00788.x
  • Influence of cytokines on neuroendocrine functions during immune response. Mechanisms involved and neuronal pathways, , Annales d'endocrinologie, 1995
  • Chondroitin sulfate proteoglycans in demyelinated lesions impair remyelination, , Annals of neurology, 2012, 10.1002/ana.23599
  • Lack of gestation-related changes of urocortin gene expression in human placenta, , Prenatal and neonatal medicine : the international journal of basic and clinical research and practice, 1999
  • Unraveling the molecular details involved in the intimate link between the immune and neuroendocrine systems, , Experimental biology and medicine (Maywood, N.J.), 2004, 10.1177/153537020422901003
  • The role of ABCB1 and ABCA1 in beta-amyloid clearance at the neurovascular unit in Alzheimer's disease, , Frontiers in physiology, 2013, 10.3389/fphys.2013.00045
  • The early contribution of cerebrovascular factors to the pathogenesis of Alzheimer's disease, , The European journal of neuroscience, 2012, 10.1111/j.1460-9568.2012.08126.x
  • The chronic intracerebroventricular infusion of interleukin-1 beta alters the activity of the hypothalamic-pituitary-gonadal axis of cycling rats. I. Effect on LHRH and gonadotropin biosynthesis and secretion, , Endocrinology, 1993, 10.1210/endo.133.6.8243260
  • Multifocal Cerebral Microinfarcts Modulate Early Alzheimer's Disease Pathology in a Sex-Dependent Manner, , Frontiers in immunology, 2021, 10.3389/fimmu.2021.813536
  • Microglia in Alzheimer's disease: A multifaceted relationship, , Brain, behavior, and immunity, 2016, 10.1016/j.bbi.2015.07.021
  • Toll-like receptor 4: the missing link of the cerebral innate immune response triggered by circulating gram-negative bacterial cell wall components, , FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2001, 10.1096/fj.00-0339com
  • Neuroprotective properties of the innate immune system and bone marrow stem cells in Alzheimer's disease, , Molecular psychiatry, 2006, 10.1038/sj.mp.4001809
  • Irradiation does not compromise or exacerbate the innate immune response in the brains of mice that were transplanted with bone marrow stem cells, , Stem cells (Dayton, Ohio), 2007, 10.1634/stemcells.2007-0508
  • PRMT1 is required for the generation of MHC-associated microglia and remyelination in the central nervous system, , Life science alliance, 2022, 10.26508/lsa.202201467
  • Boosting regulatory T cells limits neuroinflammation in permanent cortical stroke, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, 10.1523/JNEUROSCI.4901-12.2013
  • Hematopoietic MyD88-adaptor protein acts as a natural defense mechanism for cognitive deficits in Alzheimer's disease, , Stem cell reviews and reports, 2012, 10.1007/s12015-012-9356-9
  • GPR84 deficiency reduces microgliosis, but accelerates dendritic degeneration and cognitive decline in a mouse model of Alzheimer's disease, , Brain, behavior, and immunity, 2015, 10.1016/j.bbi.2015.01.010
  • A Homozygous Deep Intronic Mutation Alters the Splicing of Nebulin Gene in a Patient With Nemaline Myopathy, , Frontiers in neurology, 2021, 10.3389/fneur.2021.660113
  • Regulation of the gene encoding the monocyte chemoattractant protein 1 (MCP-1) in the mouse and rat brain in response to circulating LPS and proinflammatory cytokines, , The Journal of comparative neurology, 2001, 10.1002/cne.1187
  • QUAKING Regulates Microexon Alternative Splicing of the Rho GTPase Pathway and Controls Microglia Homeostasis, , Cell reports, 2020, 10.1016/j.celrep.2020.108560
  • Interactions between the immune and neuroendocrine systems, , Progress in brain research, 2010, 10.1016/S0079-6123(08)81004-7
  • Interleukin-6 is a needed proinflammatory cytokine in the prolonged neural activity and transcriptional activation of corticotropin-releasing factor during endotoxemia, , Endocrinology, 1999, 10.1210/endo.140.9.6983
  • Regulation of corticotropin-releasing factor type 1 (CRF1) receptor messenger ribonucleic acid in the paraventricular nucleus of rat hypothalamus by exogenous CRF, , Endocrinology, 1996, 10.1210/endo.137.11.8895325
  • Characterization of the early neuroinflammation after spinal cord injury in mice, , Journal of neuropathology and experimental neurology, 2007, 10.1097/01.jnen.0000248552.07338.7f
  • What is the cellular source of prostaglandins in the brain in response to systemic inflammation? Facts and controversies, , Molecular psychiatry, 1999
  • Toll-like receptor 2 signaling in response to brain injury: an innate bridge to neuroinflammation, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, 10.1523/JNEUROSCI.4937-05.2006
  • Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, 10.1523/JNEUROSCI.4786-03.2004
  • Effect of acute systemic inflammatory response and cytokines on the transcription of the genes encoding cyclooxygenase enzymes (COX-1 and COX-2) in the rat brain, , Journal of neurochemistry, 1998, 10.1046/j.1471-4159.1998.70020452.x
  • L'interleukine-6 dans le système nerveux central, , Medecine sciences : M/S, 2000
  • Context-dependent transcriptional regulation of microglial proliferation, , Glia, 2022, 10.1002/glia.24124
  • Tumor necrosis factor-alpha and interleukin-1 beta play a critical role in the resistance against lethal herpes simplex virus encephalitis, , The Journal of infectious diseases, 2007, 10.1086/520094
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Contribution à l'enseignement aux cycles supérieurs

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Depuis 2009
  • Ayanna Arneaud - Maîtrise avec mémoire - En cours
  • Lina Lapeyre - Doctorat - En cours
  • Majid Ghareghani - Post-doctorat - En cours
  • Peter Thériault - Maîtrise avec mémoire - 2014/05
  • Marc-André Bellavance - Doctorat - 2014/09
  • Jean-Philippe Michaud - Doctorat - 2015/01
  • Maude Bordeleau - Maîtrise avec mémoire - 2016/01
  • Yannick Tremblay - Maîtrise avec mémoire - 2016/09
  • Vincent Pons - Doctorat - 2020/09
  • Adham Fani Maleki - Doctorat - 2021/01
  • Morgan McLaughlin - Maîtrise avec mémoire - 2022/05
  • Pierre-Alexandre Piec - Maîtrise avec mémoire - 2022/05

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