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Serge Rivest

Professeur titulaire

Directeur(trice), Centre de recherche du CHU de Québec - Université Laval

Directeur(trice), Centres de recherche du CHU de Québec - UL

serge.rivest@fmed.ulaval.ca

Site personnel

Département de médecine moléculaire

Centre thématique de recherche en neurosciences

Centre de recherche du CHU de Québec - Université Laval

Centres de recherche du CHU de Québec - UL

Partager la fiche :

Contribution à la recherche

Thématiques de recherche de la Faculté de médecine

Bioinformatique / données massives (big data)
Immunologie-infectiologie
Neurosciences et santé mentale

Projets de recherche en cours

Chaire de recherche du Canada en neuroimmunologie - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2023-07-01 au 2030-06-30
Acquisition d’équipements pour les activités de recherche en oncologie de précision au Nouveau Complexe hospitalier - CHU de Québec – Université Laval – CHUL, Ministère de l'Économie et de l'Innovation - Programme de soutien aux organismes de recherche et d'innovation (PSO) - Volet 4: Soutien au financement d'infrastructures de recherche et d'innovation, chercheur principal - 2022-03-24 au 2027-03-23
Chercheur d'un jour - Conseil de recherches en sciences naturelles et génie Canada - PromoScience, chercheur principal - 2023-01-01 au 2025-12-31

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Financements des 2 dernières années

Therapeutic properties of innate immune cells and system for brain diseases - CHU de Québec – Université Laval – CHUL - Développement de la recherche (FC), chercheur principal - 2022-04-01 au 2025-03-31
Therapeutic properties of innate immune cells and system for brain diseases. - Instituts de recherche en santé du Canada - Subventions Fondation, chercheur principal - 2015-07-01 au 2022-06-30
Programme chercheur-e d'un jour - Fonds de recherche du Québec - Société et culture - Subventions générales de recherche et projets spéciaux (non partageable au prorata), co-chercheur - 2018-04-01 au 2021-03-31
Développement de marqueurs génétiques de maladies rares. - Fondation du CHU de Québec, chercheur principal - 2016-02-11 au 2020-02-10

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Publications

Effects of TNF-alpha and IFN-gamma on nitric oxide-induced neurotoxicity in the mouse brain, , Journal of immunology (Baltimore, Md. : 1950), 2004, 10.4049/jimmunol.172.11.7043
The role of microglial cell subsets in Alzheimer's disease, , Current Alzheimer research, 2011, 10.2174/156720511795256035
Interleukin-1 beta inhibits the endogenous expression of the early gene c-fos located within the nucleus of LH-RH neurons and interferes with hypothalamic LH-RH release during proestrus in the rat, , Brain research, 1993, 10.1016/0006-8993(93)90463-w
Hematopoietic MyD88-adaptor protein acts as a natural defense mechanism for cognitive deficits in Alzheimer's disease, , Stem cell reviews and reports, 2012, 10.1007/s12015-012-9356-9
Are glucocorticoids good or bad for brain development and plasticity?, , Endocrinology, 2002, 10.1210/endo.143.4.8800
Multifocal Cerebral Microinfarcts Modulate Early Alzheimer's Disease Pathology in a Sex-Dependent Manner, , Frontiers in immunology, 2021, 10.3389/fimmu.2021.813536
The combination of valacyclovir with an anti-TNF alpha antibody increases survival rate compared to antiviral therapy alone in a murine model of herpes simplex virus encephalitis, , Antiviral research, 2013, 10.1016/j.antiviral.2013.10.007
Age-related changes in synaptic markers and monocyte subsets link the cognitive decline of APP(Swe)/PS1 mice, , Frontiers in cellular neuroscience, 2012, 10.3389/fncel.2012.00051
Does circulating leptin have the ability to cross the blood-brain barrier and target neurons directly?, , Endocrinology, 2002, 10.1210/en.2002-220655
In altering the release of glucocorticoids, ketorolac exacerbates the effects of systemic immune stimuli on expression of proinflammatory genes in the brain, , Endocrinology, 2002, 10.1210/en.2002-220598
Toll-like receptor 2-independent and MyD88-dependent gene expression in the mouse brain, , Journal of innate immunity, 2009, 10.1159/000225990
Effect of a chronic stress on CRF neuronal activity and expression of its type 1 receptor in the rat brain, , The American journal of physiology, 1998, 10.1152/ajpregu.1998.275.5.R1438
Toll-like receptor 4: the missing link of the cerebral innate immune response triggered by circulating gram-negative bacterial cell wall components, , FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2001, 10.1096/fj.00-0339com
The role of exercise in thermogenesis and energy balance, , Canadian journal of physiology and pharmacology, 1989, 10.1139/y89-064
Stress and interleukin-1 beta-induced activation of c-fos, NGFI-B and CRF gene expression in the hypothalamic PVN: comparison between Sprague-Dawley, Fisher-344 and Lewis rats, , Journal of neuroendocrinology, 1994, 10.1111/j.1365-2826.1994.tb00559.x
The early contribution of cerebrovascular factors to the pathogenesis of Alzheimer's disease, , The European journal of neuroscience, 2012, 10.1111/j.1460-9568.2012.08126.x
Effects of corticotropin-releasing factor on energy balance in rats are sex dependent, , The American journal of physiology, 1989, 10.1152/ajpregu.1989.257.6.R1417
Lack of gestation-related changes of urocortin gene expression in human placenta, , Prenatal and neonatal medicine : the international journal of basic and clinical research and practice, 1999
The role of pericytes in neurovascular unit remodeling in brain disorders, , International journal of molecular sciences, 2014, 10.3390/ijms15046453
Estradiol is required for a proper immune response to bacterial and viral pathogens in the female brain, , Journal of immunology (Baltimore, Md. : 1950), 2005, 10.4049/jimmunol.174.10.6391
Sensorimotor and cognitive functions in a SOD1(G37R) transgenic mouse model of amyotrophic lateral sclerosis, , Behavioural brain research, 2011, 10.1016/j.bbr.2011.07.034
Neuronal activity and transcription of proinflammatory cytokines, IkappaBalpha, and iNOS in the mouse brain during acute endotoxemia and chronic infection with Trypanosoma brucei brucei, , Journal of neuroscience research, 1999
Innate immune reaction in response to seizures: implications for the neuropathology associated with epilepsy, , Neurobiology of disease, 2004, 10.1016/j.nbd.2004.03.010
Alcohol-induced inhibition of LH secretion in intact and gonadectomized male and female rats: possible mechanisms, , Alcoholism, clinical and experimental research, 1992, 10.1111/j.1530-0277.1992.tb01896.x
Cooperation between toll-like receptor 2 and 4 in the brain of mice challenged with cell wall components derived from gram-negative and gram-positive bacteria, , European journal of immunology, 2003, 10.1002/eji.200323821
MyD88-adaptor protein acts as a preventive mechanism for memory deficits in a mouse model of Alzheimer's disease, , Molecular neurodegeneration, 2011, 10.1186/1750-1326-6-5
Boosting regulatory T cells limits neuroinflammation in permanent cortical stroke, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, 10.1523/JNEUROSCI.4901-12.2013
New Therapeutic Avenues of mCSF for Brain Diseases and Injuries, , Frontiers in cellular neuroscience, 2018, 10.3389/fncel.2018.00499
Do pathogen exposure and innate immunity cause brain diseases?, , Neurological research, 2005, 10.1179/016164105X49526
Distribution, regulation and colocalization of the genes encoding the EP2- and EP4-PGE2 receptors in the rat brain and neuronal responses to systemic inflammation, , The European journal of neuroscience, 1999, 10.1046/j.1460-9568.1999.00682.x
Luteinizing hormone secretion and corticotropin-releasing factor gene expression in the paraventricular nucleus of rhesus monkeys following cortisol synthesis inhibition, , Endocrinology, 1997, 10.1210/endo.138.6.5171
Delayed but not early glucocorticoid treatment protects the host during experimental herpes simplex virus encephalitis in mice, , The Journal of infectious diseases, 2007, 10.1086/511987
Functional circuitry in the brain of immune-challenged rats: partial involvement of prostaglandins, , The Journal of comparative neurology, 1997, 10.1002/(sici)1096-9861(19971020)387:23.0.co;2-r
A founder mutation in the gene in families from Saguenay-Lac-St-Jean region affected by a pyridoxine-dependent epilepsy, , JIMD reports, 2021, 10.1002/jmd2.12196
How do immune cells support and shape the brain in health, disease, and aging?, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, 10.1523/JNEUROSCI.3241-13.2013
Expression of corticotropin-releasing factor and its receptors in the brain of lean and obese Zucker rats, , Endocrinology, 1996, 10.1210/endo.137.11.8895348
Is survival possible without arachidonate metabolites in the brain during systemic infection?, , News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society, 2003, 10.1152/nips.01415.2002
Effect of stress on the activity of the hypothalamic-pituitary-gonadal axis: peripheral and central mechanisms, , Biology of reproduction, 1991, 10.1095/biolreprod45.4.523
Regulation of the gene encoding the monocyte chemoattractant protein 1 (MCP-1) in the mouse and rat brain in response to circulating LPS and proinflammatory cytokines, , The Journal of comparative neurology, 2001, 10.1002/cne.1187
Activation of the nuclear factor kappa B (NF-kappaB) and cyclooxygenase-2 (COX-2) genes in cerebral blood vessels in response to systemic inflammation, , Molecular psychiatry, 1999
Characterization of the early neuroinflammation after spinal cord injury in mice, , Journal of neuropathology and experimental neurology, 2007, 10.1097/01.jnen.0000248552.07338.7f
A Ca2+-dependent mechanism of neuronal survival mediated by the microtubule-associated protein p600, , The Journal of biological chemistry, 2013, 10.1074/jbc.M113.483107
Interleukin-6 is a needed proinflammatory cytokine in the prolonged neural activity and transcriptional activation of corticotropin-releasing factor during endotoxemia, , Endocrinology, 1999, 10.1210/endo.140.9.6983
Selective Immunomodulatory and Neuroprotective Effects of a NOD2 Receptor Agonist on Mouse Models of Multiple Sclerosis, , Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2021, 10.1007/s13311-020-00998-0
QUAKING Regulates Microexon Alternative Splicing of the Rho GTPase Pathway and Controls Microglia Homeostasis, , Cell reports, 2020, 10.1016/j.celrep.2020.108560
Triggering Innate Immune Receptors as New Therapies in Alzheimer's Disease and Multiple Sclerosis, , Cells, 2021, 10.3390/cells10082164
Innate immune receptor expression in normal brain aging, , Neuroscience, 2007, 10.1016/j.neuroscience.2007.01.004
An essential role of interleukin-1beta in mediating NF-kappaB activity and COX-2 transcription in cells of the blood-brain barrier in response to a systemic and localized inflammation but not during endotoxemia, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999
Differential effects of central and peripheral injection of interleukin-1 beta on brain c-fos expression and neuroendocrine functions, , Brain research, 1992, 10.1016/0006-8993(92)91424-d
Polyamines play a critical role in the control of the innate immune response in the mouse central nervous system, , The Journal of cell biology, 2003, 10.1083/jcb.200301097
MyD88 signaling in brain endothelial cells is essential for the neuronal activity and glucocorticoid release during systemic inflammation, , Molecular psychiatry, 2008, 10.1038/sj.mp.4002122
MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1, , The Journal of biological chemistry, 2009, 10.1074/jbc.M807530200
Powerful beneficial effects of macrophage colony-stimulating factor on beta-amyloid deposition and cognitive impairment in Alzheimer's disease, , Brain : a journal of neurology, 2009, 10.1093/brain/awn331
Toll-like receptor 2 is partially involved in the activation of murine astrocytes by Streptococcus suis, an important zoonotic agent of meningitis, , Journal of neuroimmunology, 2011, 10.1016/j.jneuroim.2011.02.005
Tumor necrosis factor-alpha and interleukin-1 beta play a critical role in the resistance against lethal herpes simplex virus encephalitis, , The Journal of infectious diseases, 2007, 10.1086/520094
CRF alters the infundibular LHRH secretory system from the medial preoptic area of female rats: possible involvement of opioid receptors, , Neuroendocrinology, 1993, 10.1159/000126365
Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid beta 1-42 and delay the cognitive decline in a mouse model of Alzheimer's disease, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, 10.1523/JNEUROSCI.1146-08.2008
Blood-nerve barrier dysfunction contributes to the generation of neuropathic pain and allows targeting of injured nerves for pain relief, , Pain, 2014, 10.1016/j.pain.2014.01.026
High fat diet exacerbates Alzheimer's disease-related pathology in APPswe/PS1 mice, , Oncotarget, 2016, 10.18632/oncotarget.12179
Role of the chemokine receptors CCR2 and CX3CR1 in an experimental model of thrombotic stroke, , Brain, behavior, and immunity, 2018, 10.1016/j.bbi.2018.03.008
Stress-induced genetic expression of a selective corticotropin-releasing factor-receptor subtype within the rat ovaries: an effect dependent on the ovulatory cycle, , Biology of reproduction, 1995, 10.1095/biolreprod53.6.1417
MyD88-deficient bone marrow cells accelerate onset and reduce survival in a mouse model of amyotrophic lateral sclerosis, , The Journal of cell biology, 2007, 10.1083/jcb.200705046
Triggering of NOD2 Receptor Converts Inflammatory Ly6C into Ly6C Monocytes with Patrolling Properties, , Cell reports, 2017, 10.1016/j.celrep.2017.08.009
How circulating cytokines trigger the neural circuits that control the hypothalamic-pituitary-adrenal axis, , Psychoneuroendocrinology, 2001, 10.1016/s0306-4530(01)00064-6
Innate immunity in the CNS: redefining the relationship between the CNS and Its environment, , Neuron, 2013, 10.1016/j.neuron.2013.04.005
Effect of pretreatment with toll-like receptor agonists in a mouse model of herpes simplex virus type 1 encephalitis, , The Journal of infectious diseases, 2008, 10.1086/590671
Effect of dexfenfluramine on the transcriptional activation of CRF and its type 1 receptor within the paraventricular nucleus of the rat hypothalamus, , British journal of pharmacology, 1996, 10.1111/j.1476-5381.1996.tb16692.x
Inefficient clearance of myelin debris by microglia impairs remyelinating processes, , The Journal of experimental medicine, 2015, 10.1084/jem.20141656
Subchronic memantine administration on spatial learning, exploratory activity, and nest-building in an APP/PS1 mouse model of Alzheimer's disease, , Neuropharmacology, 2011, 10.1016/j.neuropharm.2011.01.035
Centrally injected interleukin-1 beta inhibits the hypothalamic LHRH secretion and circulating LH levels via prostaglandins in rats, , Journal of neuroendocrinology, 1993, 10.1111/j.1365-2826.1993.tb00506.x
Adrenalectomy attenuates the effect of chemical castration on energy balance in rats, , The Journal of nutrition, 1992, 10.1093/jn/122.2.369
Overproduction of corticotropin-releasing factor in transgenic mice: a genetic model of anxiogenic behavior, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 1994
Comparison of the susceptibilities of C57BL/6 and A/J mouse strains to Streptococcus suis serotype 2 infection, , Infection and immunity, 2008, 10.1128/IAI.00350-08
The bacterial endotoxin lipopolysaccharide has the ability to target the brain in upregulating its membrane CD14 receptor within specific cellular populations, , Brain pathology (Zurich, Switzerland), 1998, 10.1111/j.1750-3639.1998.tb00189.x
Regulation of the gene encoding tumor necrosis factor alpha (TNF-alpha) in the rat brain and pituitary in response in different models of systemic immune challenge, , Journal of neuropathology and experimental neurology, 1999, 10.1097/00005072-199901000-00008
A 'don't eat me' immune signal protects neuronal connections, , Nature, 2018, 10.1038/d41586-018-07165-8
The Intellicage system provides a reproducible and standardized method to assess behavioral changes in cuprizone-induced demyelination mouse model, , Behavioural brain research, 2021, 10.1016/j.bbr.2020.113039
Influence of the estrous cycle on c-fos and CRH gene transcription in the brain of endotoxin-challenged female rats, , Neuroendocrinology, 1997, 10.1159/000127162
Host immune response to Salmonella enterica serovar Typhimurium infection in mice derived from wild strains, , Infection and immunity, 2002, 10.1128/IAI.70.4.1997-2009.2002
Microglia Purinoceptor P2Y6: An Emerging Therapeutic Target in CNS Diseases, , Cells, 2020, 10.3390/cells9071595
Molecular mechanisms and neural pathways mediating the influence of interleukin-1 on the activity of neuroendocrine CRF motoneurons in the rat, , International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1995, 10.1016/0736-5748(94)00063-9
PRMT1 is required for the generation of MHC-associated microglia and remyelination in the central nervous system, , Life science alliance, 2022, 10.26508/lsa.202201467
Expression and neuropeptidergic characterization of estrogen receptors (ERalpha and ERbeta) throughout the rat brain: anatomical evidence of distinct roles of each subtype, , Journal of neurobiology, 1998, 10.1002/(sici)1097-4695(19980905)36:33.0.co;2-v
Neuroprotective properties of the innate immune system and bone marrow stem cells in Alzheimer's disease, , Molecular psychiatry, 2006, 10.1038/sj.mp.4001809
Glucocorticoids: protectors of the brain during innate immune responses, , The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2004, 10.1177/1073858404263494
The LPS receptor (CD14) links innate immunity with Alzheimer's disease, , FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004, 10.1096/fj.03-0364fje
TREM2 enables amyloid β clearance by microglia, , Cell research, 2015, 10.1038/cr.2015.37
The promise of anti-inflammatory therapies for CNS injuries and diseases, , Expert review of neurotherapeutics, 2011, 10.1586/ern.11.64
Inflammatory Monocytes and Neutrophils Regulate Streptococcus suis-Induced Systemic Inflammation and Disease but Are Not Critical for the Development of Central Nervous System Disease in a Mouse Model of Infection, , Infection and immunity, 2020, 10.1128/IAI.00787-19
Regulation of corticotropin-releasing factor type 1 (CRF1) receptor messenger ribonucleic acid in the paraventricular nucleus of rat hypothalamus by exogenous CRF, , Endocrinology, 1996, 10.1210/endo.137.11.8895325
Role of cyclo-oxygenase pathways in the stimulatory influence of immune challenge on the transcription of a specific CRF receptor subtype in the rat brain, , Journal of chemical neuroanatomy, 1996, 10.1016/0891-0618(95)00106-9
Chondroitin sulfate proteoglycans as novel drivers of leucocyte infiltration in multiple sclerosis, , Brain : a journal of neurology, 2018, 10.1093/brain/awy033
Influence of interleukin-6 on neural activity and transcription of the gene encoding corticotrophin-releasing factor in the rat brain: an effect depending upon the route of administration, , The European journal of neuroscience, 1997, 10.1111/j.1460-9568.1997.tb01500.x
Cognitive and non-cognitive behaviors in an APPswe/PS1 bigenic model of Alzheimer's disease, , Genes, brain, and behavior, 2009, 10.1111/j.1601-183X.2008.00453.x
Toll-like receptor (TLR)-2 and TLR-4 regulate inflammation, gliosis, and myelin sparing after spinal cord injury, , Journal of neurochemistry, 2007, 10.1111/j.1471-4159.2007.04524.x
Role of IL-1 and TNF in the brain: twenty years of progress on a Dr. Jekyll/Mr. Hyde duality of the innate immune system, , Brain, behavior, and immunity, 2007, 10.1016/j.bbi.2006.12.004
Inhibitory action of nitric oxide on circulating tumor necrosis factor-induced NF-kappaB activity and COX-2 transcription in the endothelium of the brain capillaries, , Journal of neuropathology and experimental neurology, 2001, 10.1093/jnen/60.9.893
Reduced corticotropin-releasing factor and enhanced vasopressin gene expression in brains of mice with autoimmunity-induced behavioral dysfunction, , Journal of neuroimmunology, 1999, 10.1016/s0165-5728(99)00021-1
Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease, , Neuron, 2006, 10.1016/j.neuron.2006.01.022
Patrolling monocytes play a critical role in CX3CR1-mediated neuroprotection during excitotoxicity, , Brain structure & function, 2015, 10.1007/s00429-014-0759-z
How the blood talks to the brain parenchyma and the paraventricular nucleus of the hypothalamus during systemic inflammatory and infectious stimuli, , Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 2000, 10.1046/j.1525-1373.2000.22304.x
An elevated matrix metalloproteinase (MMP) in an animal model of multiple sclerosis is protective by affecting Th1/Th2 polarization, , FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2005, 10.1096/fj.04-2030fje
Effects of systemic immunogenic insults and circulating proinflammatory cytokines on the transcription of the inhibitory factor kappaB alpha within specific cellular populations of the rat brain, , Journal of neurochemistry, 1999, 10.1046/j.1471-4159.1999.0730309.x
Neuronal expression of Cd36, Cd44, and Cd83 antigen transcripts maps to distinct and specific murine brain circuits, , The Journal of comparative neurology, 2009, 10.1002/cne.22185
PDK4 Inhibition Ameliorates Melatonin Therapy by Modulating Cerebral Metabolism and Remyelination in an EAE Demyelinating Mouse Model of Multiple Sclerosis, , Frontiers in immunology, 2022, 10.3389/fimmu.2022.862316
Microglia Ontology and Signaling, , Frontiers in cell and developmental biology, 2016, 10.3389/fcell.2016.00072
Stimulation of monocytes, macrophages, and microglia by amphotericin B and macrophage colony-stimulating factor promotes remyelination, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015, 10.1523/JNEUROSCI.1797-14.2015
Effect of immune and metabolic challenges on the luteinizing hormone-releasing hormone neuronal system in cycling female rats: an evaluation at the transcriptional level, , Endocrinology, 1997, 10.1210/endo.138.4.5044
Streptococcus suis serotype 2, an important swine and human pathogen, induces strong systemic and cerebral inflammatory responses in a mouse model of infection, , Journal of immunology (Baltimore, Md. : 1950), 2007, 10.4049/jimmunol.179.3.1842
Tumor necrosis factor alpha but not interleukin 1 beta mediates neuroprotection in response to acute nitric oxide excitotoxicity, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, 10.1523/JNEUROSCI.4032-05.2006
Microglia: Senescence Impairs Clearance of Myelin Debris, , Current biology : CB, 2016, 10.1016/j.cub.2016.06.066
Correction to: Selective Immunomodulatory and Neuroprotective Effects of a NOD2 Receptor Agonist on Mouse Models of Multiple Sclerosis, , Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2021, 10.1007/s13311-021-01035-4
IL-1RAcPb signaling regulates adaptive mechanisms in neurons that promote their long-term survival following excitotoxic insults, , Frontiers in cellular neuroscience, 2013, 10.3389/fncel.2013.00009
Ovulatory cycle influences the stimulatory effect of stress on the expression of corticotropin-releasing factor receptor messenger ribonucleic acid in the paraventricular nucleus of the female rat hypothalamus, , Endocrinology, 1995, 10.1210/endo.136.9.7649116
Alzheimer's disease: microglia targets and their modulation to promote amyloid phagocytosis and mitigate neuroinflammation, , Expert opinion on therapeutic targets, 2020, 10.1080/14728222.2020.1738391
Corticotropin-releasing factor (CRF) and stress-related reproductive failure: the brain as a state of the art or the ovary as a novel clue?, , Journal of endocrinological investigation, 1995, 10.1007/BF03349836
Role of the innate immune response in the brain, , Medecine sciences : M/S, 2003, 10.1051/medsci/20031910981
Effect of immobilization stress on transcriptional activity of inducible immediate-early genes, corticotropin-releasing factor, its type 1 receptor, and enkephalin in the hypothalamus of borderline hypertensive rats, , Journal of neurochemistry, 1998, 10.1046/j.1471-4159.1998.70041556.x
Effects of mild chronic cerebral hypoperfusion and early amyloid pathology on spatial learning and the cellular innate immune response in mice, , Neurobiology of aging, 2013, 10.1016/j.neurobiolaging.2012.06.025
Ultrastructural evidence of microglial heterogeneity in Alzheimer's disease amyloid pathology, , Journal of neuroinflammation, 2019, 10.1186/s12974-019-1473-9
Anti-inflammatory signaling in microglia exacerbates Alzheimer's disease-related pathology, , Neuron, 2015, 10.1016/j.neuron.2015.01.021
Fluoxetine induces the transcription of genes encoding c-fos, corticotropin-releasing factor and its type 1 receptor in rat brain, , Neuroscience, 1998, 10.1016/s0306-4522(98)00147-x
Whole-exome sequencing identifies homozygous mutation in TTI2 in a child with primary microcephaly: a case report, , BMC neurology, 2020, 10.1186/s12883-020-01643-1
Modulation of the innate immune response by NMDA receptors has neuropathological consequences, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003
Immunosenescence of microglia and macrophages: impact on the ageing central nervous system, , Brain : a journal of neurology, 2016, 10.1093/brain/awv395
Genes involved in the balance between neuronal survival and death during inflammation, , PloS one, 2007, 10.1371/journal.pone.0000310
Corticotropin-releasing factor activates c-fos, NGFI-B, and corticotropin-releasing factor gene expression within the paraventricular nucleus of the rat hypothalamus, , Molecular endocrinology (Baltimore, Md.), 1993, 10.1210/mend.7.10.8264665
Central nervous system-initiated inflammation and neurotrophism in trauma: IL-1 beta is required for the production of ciliary neurotrophic factor, , Journal of immunology (Baltimore, Md. : 1950), 2000, 10.4049/jimmunol.165.4.2232
Estrogen receptor transrepresses brain inflammation, , Cell, 2011, 10.1016/j.cell.2011.04.018
Targeting Systemic Innate Immune Cells as a Therapeutic Avenue for Alzheimer Disease, , Pharmacological reviews, 2022, 10.1124/pharmrev.121.000400
Functional recovery after peripheral nerve injury is dependent on the pro-inflammatory cytokines IL-1β and TNF: implications for neuropathic pain, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, 10.1523/JNEUROSCI.2840-11.2011
The complement system is an integrated part of the natural innate immune response in the brain, , FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2001, 10.1096/fj.00-0709fje
Chemokine expression by glial cells directs leukocytes to sites of axonal injury in the CNS, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003
C-fos mRNA pattern and corticotropin-releasing factor neuronal activity throughout the brain of rats injected centrally with a prostaglandin of E2 type, , Journal of neuroimmunology, 1996, 10.1016/s0165-5728(96)00114-2
Migration of bone marrow-derived cells into the central nervous system in models of neurodegeneration, , The Journal of comparative neurology, 2013, 10.1002/cne.23363
Cannabinoids in microglia: a new trick for immune surveillance and neuroprotection, , Neuron, 2006, 10.1016/j.neuron.2005.12.004
The 5-hydroxytryptamine agonist fenfluramine increases Fos-like immunoreactivity in the brain, , Brain research, 1992, 10.1016/0006-8993(92)91037-f
CX3CR1 in multiple sclerosis, , Oncotarget, 2015, 10.18632/oncotarget.4650
Lesions of hypothalamic PVN partially attenuate stimulatory action of alcohol on ACTH secretion in rats, , The American journal of physiology, 1994, 10.1152/ajpregu.1994.266.2.R553
Case Report: Two Families With HPDL Related Neurodegeneration, , Frontiers in genetics, 2022, 10.3389/fgene.2022.780764
What is the cellular source of prostaglandins in the brain in response to systemic inflammation? Facts and controversies, , Molecular psychiatry, 1999
The hematopoietic cytokine M-CSF as a cure for Alzheimer's disease, , Medecine sciences : M/S, 2009, 10.1051/medsci/2009258-9666
Involvement of corticotropin-releasing factor in the anorexia induced by exercise, , Brain research bulletin, 1990, 10.1016/0361-9230(90)90270-a
The impact of Ly6Clow monocytes after cerebral hypoxia-ischemia in adult mice, , Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, 10.1038/jcbfm.2014.80
Role of Macrophage Colony-Stimulating Factor Receptor on the Proliferation and Survival of Microglia Following Systemic Nerve and Cuprizone-Induced Injuries, , Frontiers in immunology, 2020, 10.3389/fimmu.2020.00047
Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, 10.1523/JNEUROSCI.4786-03.2004
Corticotropin-releasing factor and glucocorticoid receptor (GR) gene expression in the paraventricular nucleus of immune-challenged transgenic mice expressing type II GR antisense ribonucleic acid, , Journal of molecular neuroscience : MN, 1997, 10.1007/BF02736831
Molecular and cellular immune mediators of neuroprotection, , Molecular neurobiology, 2006, 10.1385/MN:34:3:221
Early monocyte modulation by the non-erythropoietic peptide ARA 290 decelerates AD-like pathology progression, , Brain, behavior, and immunity, 2022, 10.1016/j.bbi.2021.07.016
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