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Serge Rivest

Professeur titulaire

Directeur(trice), Centre de recherche du CHU de Québec - Université Laval

Directeur(trice), Centres de recherche du CHU de Québec - UL

Serge Rivest
serge.rivest@fmed.ulaval.ca
Centre thématique de recherche en neurosciences
Centre de recherche du CHU de Québec - Université Laval
Centres de recherche du CHU de Québec - UL
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Bioinformatique / données massives (big data)
Immunologie-infectiologie
Neurosciences et santé mentale

Domaines et intérêts de recherche du (de la) professeur(e) :

Maladies infectieuses et immunitaires
  • Développement de vaccins
  • Immunothérapie
  • Maladies auto-immunes
  • Système immunitaire
Neurosciences, santé mentale et toxicomanies
  • Démences
  • Maladie d'Alzheimer
  • Maladies neurodégénératives
  • Maladies neuroimmunologiques
  • Sclérose en plaques
Vieillissement
  • Dégénérescence cellulaire
  • Vieillissement cellulaire

Projets de recherche

  • Chaire de recherche du Canada en neuroimmunologie - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2023-07-01 au 2030-06-30
  • Acquisition d’équipements pour les activités de recherche en oncologie de précision au Nouveau Complexe hospitalier - CHU de Québec – Université Laval – CHUL, Ministère de l'Économie et de l'Innovation - Programme de soutien aux organismes de recherche et d'innovation (PSO) - Volet 4: Soutien au financement d'infrastructures de recherche et d'innovation, chercheur principal - 2022-03-24 au 2027-03-23
  • Chercheur d'un jour - Conseil de recherches en sciences naturelles et génie Canada - PromoScience, chercheur principal - 2023-01-01 au 2025-12-31
  • Therapeutic properties of innate immune cells and system for brain diseases - CHU de Québec – Université Laval – CHUL - Développement de la recherche (FC), chercheur principal - 2022-04-01 au 2025-03-31
  • Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
  • Chaire de recherche du Canada en neuroimmunologie - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2016-07-01 au 2023-06-30
  • Chercheur d'un jour - Conseil de recherches en sciences naturelles et génie Canada - PromoScience, chercheur principal - 2021-01-01 au 2022-12-31
  • Therapeutic properties of innate immune cells and system for brain diseases. - Instituts de recherche en santé du Canada - Subventions Fondation, chercheur principal - 2015-07-01 au 2022-06-30
  • Soutenir les établissements dans l'augmentation de leur capacité en recherche - agir sur la phase de démarrage des projets, Phase 2 - Ministère de l'Économie et de l'Innovation - Programme de soutien aux organismes de recherche et d’innovation (PSO) - Recherche-innovation - Volet 2a, chercheur principal - 2020-04-01 au 2022-03-31
  • Programme de soutien aux organismes de recherche et d'innovation (MESI_CATALIS Volet 2 - Recherche clinique) - Ministère de l'Économie et de l'Innovation - Programme de soutien aux organismes de recherche et d'innovation (volet 2a). Appels de projets en innovation sociale au bénéfice du développement économique local et durable, chercheur principal - 2020-04-23 au 2022-03-31
  • Développement de marqueurs génétiques de maladies rares. - Fondation du CHU de Québec, chercheur principal - 2016-02-11 au 2020-02-10

Publications

  • Effects of corticotropin-releasing factor on energy balance in rats are sex dependent, , The American journal of physiology, 1989, 10.1152/ajpregu.1989.257.6.R1417
  • The role of exercise in thermogenesis and energy balance, , Canadian journal of physiology and pharmacology, 1989, 10.1139/y89-064
  • Hypothalamic paraventricular nucleus lesions do not prevent anorectic effect of exercise in male rats, , The American journal of physiology, 1990, 10.1152/ajpregu.1990.259.3.R579
  • Interleukin-1 beta inhibits the endogenous expression of the early gene c-fos located within the nucleus of LH-RH neurons and interferes with hypothalamic LH-RH release during proestrus in the rat, , Brain research, 1993, 10.1016/0006-8993(93)90463-w
  • Lesions of hypothalamic PVN partially attenuate stimulatory action of alcohol on ACTH secretion in rats, , The American journal of physiology, 1994, 10.1152/ajpregu.1994.266.2.R553
  • The role of corticotropin-releasing factor and interleukin-1 in the regulation of neurons controlling reproductive functions, , Endocrine reviews, 1995, 10.1210/edrv-16-2-177
  • Stress-induced genetic expression of a selective corticotropin-releasing factor-receptor subtype within the rat ovaries: an effect dependent on the ovulatory cycle, , Biology of reproduction, 1995, 10.1095/biolreprod53.6.1417
  • Ovulatory cycle influences the stimulatory effect of stress on the expression of corticotropin-releasing factor receptor messenger ribonucleic acid in the paraventricular nucleus of the female rat hypothalamus, , Endocrinology, 1995, 10.1210/endo.136.9.7649116
  • Neuronal activity and neuropeptide gene transcription in the brains of immune-challenged rats, , Journal of neuroendocrinology, 1995, 10.1111/j.1365-2826.1995.tb00788.x
  • Aging female brain: is there a change of adaptive stress?, , Aging (Milan, Italy), 1997, 10.1007/BF03339711
  • Effect of immune and metabolic challenges on the luteinizing hormone-releasing hormone neuronal system in cycling female rats: an evaluation at the transcriptional level, , Endocrinology, 1997, 10.1210/endo.138.4.5044
  • Luteinizing hormone secretion and corticotropin-releasing factor gene expression in the paraventricular nucleus of rhesus monkeys following cortisol synthesis inhibition, , Endocrinology, 1997, 10.1210/endo.138.6.5171
  • Neuronal activation of the hypothalamic magnocellular system in response to oropharyngeal stimuli in the rat, , Journal of neuroendocrinology, 1997, 10.1046/j.1365-2826.1997.00573.x
  • C-fos mRNA pattern and corticotropin-releasing factor neuronal activity throughout the brain of rats injected centrally with a prostaglandin of E2 type, , Journal of neuroimmunology, 1996, 10.1016/s0165-5728(96)00114-2
  • Expression of corticotropin-releasing factor and its receptors in the brain of lean and obese Zucker rats, , Endocrinology, 1996, 10.1210/endo.137.11.8895348
  • Regulation of the gene encoding tumor necrosis factor alpha (TNF-alpha) in the rat brain and pituitary in response in different models of systemic immune challenge, , Journal of neuropathology and experimental neurology, 1999, 10.1097/00005072-199901000-00008
  • Molecular mechanisms and neural pathways mediating the influence of interleukin-1 on the activity of neuroendocrine CRF motoneurons in the rat, , International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1995, 10.1016/0736-5748(94)00063-9
  • Influence of cytokines on neuroendocrine functions during immune response. Mechanisms involved and neuronal pathways, , Annales d'endocrinologie, 1995
  • Reduced corticotropin-releasing factor and enhanced vasopressin gene expression in brains of mice with autoimmunity-induced behavioral dysfunction, , Journal of neuroimmunology, 1999, 10.1016/s0165-5728(99)00021-1
  • Neuronal activity and transcription of proinflammatory cytokines, IkappaBalpha, and iNOS in the mouse brain during acute endotoxemia and chronic infection with Trypanosoma brucei brucei, , Journal of neuroscience research, 1999
  • Lack of gestation-related changes of urocortin gene expression in human placenta, , Prenatal and neonatal medicine : the international journal of basic and clinical research and practice, 1999
  • Involvement of serotonergic pathways in mediating the neuronal activity and genetic transcription of neuroendocrine corticotropin-releasing factor in the brain of systemically endotoxin-challenged rats, , Neuroscience, 1999, 10.1016/s0306-4522(98)00369-8
  • Immune response and brain gene expression in relation to stress, , 1999
  • Distribution, regulation and colocalization of the genes encoding the EP2- and EP4-PGE2 receptors in the rat brain and neuronal responses to systemic inflammation, , The European journal of neuroscience, 1999, 10.1046/j.1460-9568.1999.00682.x
  • Central nervous system-initiated inflammation and neurotrophism in trauma: IL-1 beta is required for the production of ciliary neurotrophic factor, , Journal of immunology (Baltimore, Md. : 1950), 2000, 10.4049/jimmunol.165.4.2232
  • How the blood talks to the brain parenchyma and the paraventricular nucleus of the hypothalamus during systemic inflammatory and infectious stimuli, , Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 2000, 10.1046/j.1525-1373.2000.22304.x
  • Innate immune reaction in response to seizures: implications for the neuropathology associated with epilepsy, , Neurobiology of disease, 2004, 10.1016/j.nbd.2004.03.010
  • An adverse role for matrix metalloproteinase 12 after spinal cord injury in mice, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003
  • Modulation of the innate immune response by NMDA receptors has neuropathological consequences, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003
  • Does circulating leptin have the ability to cross the blood-brain barrier and target neurons directly?, , Endocrinology, 2002, 10.1210/en.2002-220655
  • Innate immunity: the missing link in neuroprotection and neurodegeneration?, , Nature reviews. Neuroscience, 2002, 10.1038/nrn752
  • Perspective: how to make microarray, serial analysis of gene expression, and proteomic relevant to day-to-day endocrine problems and physiological systems, , Endocrinology, 2002, 10.1210/endo.143.6.8868
  • The clinical course of experimental autoimmune encephalomyelitis is associated with a profound and sustained transcriptional activation of the genes encoding toll-like receptor 2 and CD14 in the mouse CNS, , Brain pathology (Zurich, Switzerland), 2002, 10.1111/j.1750-3639.2002.tb00445.x
  • Inhibitory action of nitric oxide on circulating tumor necrosis factor-induced NF-kappaB activity and COX-2 transcription in the endothelium of the brain capillaries, , Journal of neuropathology and experimental neurology, 2001, 10.1093/jnen/60.9.893
  • Regulation of the gene encoding the monocyte chemoattractant protein 1 (MCP-1) in the mouse and rat brain in response to circulating LPS and proinflammatory cytokines, , The Journal of comparative neurology, 2001, 10.1002/cne.1187
  • Cyclooxygenase 2 (COX-2) inhibition increases the inflammatory response in the brain during systemic immune stimuli, , Journal of neurochemistry, 2005, 10.1111/j.1471-4159.2005.03480.x
  • Do pathogen exposure and innate immunity cause brain diseases?, , Neurological research, 2005, 10.1179/016164105X49526
  • Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, 10.1523/JNEUROSCI.4786-03.2004
  • Neuroprotective properties of the innate immune system and bone marrow stem cells in Alzheimer's disease, , Molecular psychiatry, 2006, 10.1038/sj.mp.4001809
  • Innate immunity triggers oligodendrocyte progenitor reactivity and confines damages to brain injuries, , FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2006, 10.1096/fj.05-5234fje
  • Cannabinoids in microglia: a new trick for immune surveillance and neuroprotection, , Neuron, 2006, 10.1016/j.neuron.2005.12.004
  • Role of IL-1 and TNF in the brain: twenty years of progress on a Dr. Jekyll/Mr. Hyde duality of the innate immune system, , Brain, behavior, and immunity, 2007, 10.1016/j.bbi.2006.12.004
  • Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease, , Neuron, 2006, 10.1016/j.neuron.2006.01.022
  • Immunotherapy for neurological diseases, , Clinical immunology (Orlando, Fla.), 2008, 10.1016/j.clim.2008.04.003
  • Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid beta 1-42 and delay the cognitive decline in a mouse model of Alzheimer's disease, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, 10.1523/JNEUROSCI.1146-08.2008
  • Irradiation does not compromise or exacerbate the innate immune response in the brains of mice that were transplanted with bone marrow stem cells, , Stem cells (Dayton, Ohio), 2007, 10.1634/stemcells.2007-0508
  • Neuroprotective effects of resident microglia following acute brain injury, , The Journal of comparative neurology, 2007, 10.1002/cne.21469
  • Targeting the hematopoietic system for the treatment of Alzheimer's disease, , Brain, behavior, and immunity, 2011, 10.1016/j.bbi.2010.12.018
  • Interactions between the immune and neuroendocrine systems, , Progress in brain research, 2010, 10.1016/S0079-6123(08)81004-7
  • A central nervous system-restricted isoform of the interleukin-1 receptor accessory protein modulates neuronal responses to interleukin-1, , Immunity, 2009, 10.1016/j.immuni.2009.03.020
  • Cognitive and non-cognitive behaviors in an APPswe/PS1 bigenic model of Alzheimer's disease, , Genes, brain, and behavior, 2009, 10.1111/j.1601-183X.2008.00453.x
  • Toll-like receptor 2-independent and MyD88-dependent gene expression in the mouse brain, , Journal of innate immunity, 2009, 10.1159/000225990
  • Regulation of innate immune responses in the brain, , Nature reviews. Immunology, 2009, 10.1038/nri2565
  • The hematopoietic cytokine M-CSF as a cure for Alzheimer's disease, , Medecine sciences : M/S, 2009, 10.1051/medsci/2009258-9666
  • Lipid metabolism and neuroinflammation in Alzheimer's disease: a role for liver X receptors, , Endocrine reviews, 2012, 10.1210/er.2011-1049
  • Anomalies in social behaviors and exploratory activities in an APPswe/PS1 mouse model of Alzheimer's disease, , Physiology & behavior, 2011, 10.1016/j.physbeh.2011.05.023
  • CC chemokine receptor 2 deficiency aggravates cognitive impairments and amyloid pathology in a transgenic mouse model of Alzheimer's disease, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, 10.1523/JNEUROSCI.0299-11.2011
  • Migration of bone marrow-derived cells into the central nervous system in models of neurodegeneration, , The Journal of comparative neurology, 2013, 10.1002/cne.23363
  • The combination of valacyclovir with an anti-TNF alpha antibody increases survival rate compared to antiviral therapy alone in a murine model of herpes simplex virus encephalitis, , Antiviral research, 2013, 10.1016/j.antiviral.2013.10.007
  • Age-related changes in synaptic markers and monocyte subsets link the cognitive decline of APP(Swe)/PS1 mice, , Frontiers in cellular neuroscience, 2012, 10.3389/fncel.2012.00051
  • Hematopoietic MyD88-adaptor protein acts as a natural defense mechanism for cognitive deficits in Alzheimer's disease, , Stem cell reviews and reports, 2012, 10.1007/s12015-012-9356-9
  • Immune receptors involved in Streptococcus suis recognition by dendritic cells, , PloS one, 2012, 10.1371/journal.pone.0044746
  • Impact of deficiency in CCR2 and CX3CR1 receptors on monocytes trafficking in herpes simplex virus encephalitis, , The Journal of general virology, 2012, 10.1099/vir.0.041046-0
  • Boosting regulatory T cells limits neuroinflammation in permanent cortical stroke, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, 10.1523/JNEUROSCI.4901-12.2013
  • Patrolling monocytes play a critical role in CX3CR1-mediated neuroprotection during excitotoxicity, , Brain structure & function, 2015, 10.1007/s00429-014-0759-z
  • Blood-nerve barrier dysfunction contributes to the generation of neuropathic pain and allows targeting of injured nerves for pain relief, , Pain, 2014, 10.1016/j.pain.2014.01.026
  • Interactions between microglia and T cells in multiple sclerosis pathobiology, , Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2014, 10.1089/jir.2014.0019
  • The HPA - Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain, , Frontiers in immunology, 2014, 10.3389/fimmu.2014.00136
  • A Ca2+-dependent mechanism of neuronal survival mediated by the microtubule-associated protein p600, , The Journal of biological chemistry, 2013, 10.1074/jbc.M113.483107
  • GPR84 deficiency reduces microgliosis, but accelerates dendritic degeneration and cognitive decline in a mouse model of Alzheimer's disease, , Brain, behavior, and immunity, 2015, 10.1016/j.bbi.2015.01.010
  • Inefficient clearance of myelin debris by microglia impairs remyelinating processes, , The Journal of experimental medicine, 2015, 10.1084/jem.20141656
  • CX3CR1 in multiple sclerosis, , Oncotarget, 2015, 10.18632/oncotarget.4650
  • Chondroitin sulfate proteoglycans as novel drivers of leucocyte infiltration in multiple sclerosis, , Brain : a journal of neurology, 2018, 10.1093/brain/awy033
  • New Therapeutic Avenues of mCSF for Brain Diseases and Injuries, , Frontiers in cellular neuroscience, 2018, 10.3389/fncel.2018.00499
  • Immunosenescence of microglia and macrophages: impact on the ageing central nervous system, , Brain : a journal of neurology, 2016, 10.1093/brain/awv395
  • Microglia: Senescence Impairs Clearance of Myelin Debris, , Current biology : CB, 2016, 10.1016/j.cub.2016.06.066
  • Tissue-Plasminogen Activator Attenuates Alzheimer's Disease-Related Pathology Development in APPswe/PS1 Mice, , Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016, 10.1038/npp.2015.279
  • C-C chemokine receptor type 2 (CCR2) signaling protects neonatal male mice with hypoxic-ischemic hippocampal damage from developing spatial learning deficits, , Behavioural brain research, 2015, 10.1016/j.bbr.2015.02.053
  • Innate Immune Cells: Monocytes, Monocyte-Derived Macrophages and Microglia as Therapeutic Targets for Alzheimer's Disease and Multiple Sclerosis, , Frontiers in cellular neuroscience, 2019, 10.3389/fncel.2019.00355
  • A 'don't eat me' immune signal protects neuronal connections, , Nature, 2018, 10.1038/d41586-018-07165-8
  • Bone Marrow Chimeras to Study Neuroinflammation, , Current protocols in immunology, 2018, 10.1002/cpim.56
  • Selective Immunomodulatory and Neuroprotective Effects of a NOD2 Receptor Agonist on Mouse Models of Multiple Sclerosis, , Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2021, 10.1007/s13311-020-00998-0
  • An Early Microglial Response Is Needed To Efficiently Control Herpes Simplex Virus Encephalitis, , Journal of virology, 2020, 10.1128/JVI.01428-20
  • Inflammatory Monocytes and Neutrophils Regulate Streptococcus suis-Induced Systemic Inflammation and Disease but Are Not Critical for the Development of Central Nervous System Disease in a Mouse Model of Infection, , Infection and immunity, 2020, 10.1128/IAI.00787-19
  • Role of Macrophage Colony-Stimulating Factor Receptor on the Proliferation and Survival of Microglia Following Systemic Nerve and Cuprizone-Induced Injuries, , Frontiers in immunology, 2020, 10.3389/fimmu.2020.00047
  • Reduced Melatonin Levels May Facilitate Glioblastoma Initiation in the Subventricular Zone, , Expert reviews in molecular medicine, 2022, 10.1017/erm.2022.15
  • Targeting Systemic Innate Immune Cells as a Therapeutic Avenue for Alzheimer Disease, , Pharmacological reviews, 2022, 10.1124/pharmrev.121.000400
  • Conditional genetic deletion of CSF1 receptor in microglia ameliorates the physiopathology of Alzheimer's disease, , Alzheimer's research & therapy, 2021, 10.1186/s13195-020-00747-7
  • Tissue specificity of SNS response to exercise in mice exposed to low temperatures, , The American journal of physiology, 1992, 10.1152/ajpregu.1992.262.5.R921
  • Effect of stress on the activity of the hypothalamic-pituitary-gonadal axis: peripheral and central mechanisms, , Biology of reproduction, 1991, 10.1095/biolreprod45.4.523
  • Effects of exercise on energy balance in meal-fed mice, , Physiology & behavior, 1991, 10.1016/0031-9384(91)90043-n
  • Involvement of corticotropin-releasing factor in the anorexia induced by exercise, , Brain research bulletin, 1990, 10.1016/0361-9230(90)90270-a
  • Effect of exercise training on energy balance of orchidectomized rats, , The American journal of physiology, 1989, 10.1152/ajpregu.1989.257.3.R550
  • Alcohol-induced inhibition of LH secretion in intact and gonadectomized male and female rats: possible mechanisms, , Alcoholism, clinical and experimental research, 1992, 10.1111/j.1530-0277.1992.tb01896.x
  • Effect of dexfenfluramine on the transcriptional activation of CRF and its type 1 receptor within the paraventricular nucleus of the rat hypothalamus, , British journal of pharmacology, 1996, 10.1111/j.1476-5381.1996.tb16692.x
  • Regulation of corticotropin-releasing factor type 1 (CRF1) receptor messenger ribonucleic acid in the paraventricular nucleus of rat hypothalamus by exogenous CRF, , Endocrinology, 1996, 10.1210/endo.137.11.8895325
  • Corticotropin-releasing factor (CRF) and stress-related reproductive failure: the brain as a state of the art or the ovary as a novel clue?, , Journal of endocrinological investigation, 1995, 10.1007/BF03349836
  • CRF alters the infundibular LHRH secretory system from the medial preoptic area of female rats: possible involvement of opioid receptors, , Neuroendocrinology, 1993, 10.1159/000126365
  • Functional circuitry in the brain of immune-challenged rats: partial involvement of prostaglandins, , The Journal of comparative neurology, 1997, 10.1002/(sici)1096-9861(19971020)387:23.0.co;2-r
  • Influence of interleukin-6 on neural activity and transcription of the gene encoding corticotrophin-releasing factor in the rat brain: an effect depending upon the route of administration, , The European journal of neuroscience, 1997, 10.1111/j.1460-9568.1997.tb01500.x
  • Adrenalectomy attenuates the effect of chemical castration on energy balance in rats, , The Journal of nutrition, 1992, 10.1093/jn/122.2.369
  • Corticotropin-releasing factor activates c-fos, NGFI-B, and corticotropin-releasing factor gene expression within the paraventricular nucleus of the rat hypothalamus, , Molecular endocrinology (Baltimore, Md.), 1993, 10.1210/mend.7.10.8264665
  • Central mechanisms and sites of action involved in the inhibitory effects of CRF and cytokines on LHRH neuronal activity, , Annals of the New York Academy of Sciences, 1993, 10.1111/j.1749-6632.1993.tb49928.x
  • Regulation of the genes encoding interleukin-6, its receptor, and gp130 in the rat brain in response to the immune activator lipopolysaccharide and the proinflammatory cytokine interleukin-1beta, , Journal of neurochemistry, 1997, 10.1046/j.1471-4159.1997.69041668.x
  • Expression and neuropeptidergic characterization of estrogen receptors (ERalpha and ERbeta) throughout the rat brain: anatomical evidence of distinct roles of each subtype, , Journal of neurobiology, 1998, 10.1002/(sici)1097-4695(19980905)36:33.0.co;2-v
  • Effect of acute systemic inflammatory response and cytokines on the transcription of the genes encoding cyclooxygenase enzymes (COX-1 and COX-2) in the rat brain, , Journal of neurochemistry, 1998, 10.1046/j.1471-4159.1998.70020452.x
  • Effect of immobilization stress on transcriptional activity of inducible immediate-early genes, corticotropin-releasing factor, its type 1 receptor, and enkephalin in the hypothalamus of borderline hypertensive rats, , Journal of neurochemistry, 1998, 10.1046/j.1471-4159.1998.70041556.x
  • What is the cellular source of prostaglandins in the brain in response to systemic inflammation? Facts and controversies, , Molecular psychiatry, 1999
  • Effect of a chronic stress on CRF neuronal activity and expression of its type 1 receptor in the rat brain, , The American journal of physiology, 1998, 10.1152/ajpregu.1998.275.5.R1438
  • Effects of circulating tumor necrosis factor on the neuronal activity and expression of the genes encoding the tumor necrosis factor receptors (p55 and p75) in the rat brain: a view from the blood-brain barrier, , Neuroscience, 1999, 10.1016/s0306-4522(99)00225-0
  • Effects of systemic immunogenic insults and circulating proinflammatory cytokines on the transcription of the inhibitory factor kappaB alpha within specific cellular populations of the rat brain, , Journal of neurochemistry, 1999, 10.1046/j.1471-4159.1999.0730309.x
  • Toll-like receptor 4: the missing link of the cerebral innate immune response triggered by circulating gram-negative bacterial cell wall components, , FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2001, 10.1096/fj.00-0339com
  • Activation of the nuclear factor kappa B (NF-kappaB) and cyclooxygenase-2 (COX-2) genes in cerebral blood vessels in response to systemic inflammation, , Molecular psychiatry, 1999
  • Proinflammatory signal transduction pathways in the CNS during systemic immune response, , 2001
  • The complement system is an integrated part of the natural innate immune response in the brain, , FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2001, 10.1096/fj.00-0709fje
  • Intranasal herpes simplex virus type 2 inoculation causes a profound thymidine kinase dependent cerebral inflammatory response in the mouse hindbrain, , The European journal of neuroscience, 2002, 10.1046/j.1460-9568.2002.02057.x
  • Anti-inflammatory effects of prostaglandin E2 in the central nervous system in response to brain injury and circulating lipopolysaccharide, , Journal of neurochemistry, 2001, 10.1046/j.1471-4159.2001.00080.x
  • Molecular insights on the cerebral innate immune system, , Brain, behavior, and immunity, 2003, 10.1016/s0889-1591(02)00055-7
  • Polyamines play a critical role in the control of the innate immune response in the mouse central nervous system, , The Journal of cell biology, 2003, 10.1083/jcb.200301097
  • Role of the innate immune response in the brain, , Medecine sciences : M/S, 2003, 10.1051/medsci/20031910981
  • Endotoxemia prevents the cerebral inflammatory wave induced by intraparenchymal lipopolysaccharide injection: role of glucocorticoids and CD14, , Journal of immunology (Baltimore, Md. : 1950), 2002, 10.4049/jimmunol.169.6.3370
  • Immune Function and Regulation of the Autonomic Nervous System: A Molecular Point of View, , 2003
  • Is survival possible without arachidonate metabolites in the brain during systemic infection?, , News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society, 2003, 10.1152/nips.01415.2002
  • Glucocorticoids play a fundamental role in protecting the brain during innate immune response, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003
  • MyD88-adaptor protein acts as a preventive mechanism for memory deficits in a mouse model of Alzheimer's disease, , Molecular neurodegeneration, 2011, 10.1186/1750-1326-6-5
  • The role of microglial cell subsets in Alzheimer's disease, , Current Alzheimer research, 2011, 10.2174/156720511795256035
  • Toll-like receptor 2 is partially involved in the activation of murine astrocytes by Streptococcus suis, an important zoonotic agent of meningitis, , Journal of neuroimmunology, 2011, 10.1016/j.jneuroim.2011.02.005
  • Oncostatin M is a novel glucocorticoid-dependent neuroinflammatory factor that enhances oligodendrocyte precursor cell activity in demyelinated sites, , Brain, behavior, and immunity, 2010, 10.1016/j.bbi.2010.01.005
  • Powerful beneficial effects of macrophage colony-stimulating factor on beta-amyloid deposition and cognitive impairment in Alzheimer's disease, , Brain : a journal of neurology, 2009, 10.1093/brain/awn331
  • Comparison of the susceptibilities of C57BL/6 and A/J mouse strains to Streptococcus suis serotype 2 infection, , Infection and immunity, 2008, 10.1128/IAI.00350-08
  • Effect of pretreatment with toll-like receptor agonists in a mouse model of herpes simplex virus type 1 encephalitis, , The Journal of infectious diseases, 2008, 10.1086/590671
  • Microglia, , Current biology : CB, 2008, 10.1016/j.cub.2008.04.047
  • MyD88 signaling in brain endothelial cells is essential for the neuronal activity and glucocorticoid release during systemic inflammation, , Molecular psychiatry, 2008, 10.1038/sj.mp.4002122
  • Characterization of the early neuroinflammation after spinal cord injury in mice, , Journal of neuropathology and experimental neurology, 2007, 10.1097/01.jnen.0000248552.07338.7f
  • Expression of CCR2 in both resident and bone marrow-derived microglia plays a critical role in neuropathic pain, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, 10.1523/JNEUROSCI.3016-07.2007
  • Genes involved in the balance between neuronal survival and death during inflammation, , PloS one, 2007, 10.1371/journal.pone.0000310
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Contribution à l'enseignement aux cycles supérieurs

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Depuis 2009
  • Majid Ghareghani - Post-doctorat - En cours
  • Lina Lapeyre - Doctorat - En cours
  • Peter Thériault - Maîtrise avec mémoire - 2014/05
  • Marc-André Bellavance - Doctorat - 2014/09
  • Jean-Philippe Michaud - Doctorat - 2015/01
  • Maude Bordeleau - Maîtrise avec mémoire - 2016/01
  • Yannick Tremblay - Maîtrise avec mémoire - 2016/09
  • Vincent Pons - Doctorat - 2020/09
  • Adham Fani Maleki - Doctorat - 2021/01
  • Morgan McLaughlin - Maîtrise avec mémoire - 2022/05
  • Pierre-Alexandre Piec - Maîtrise avec mémoire - 2022/05

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