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Sébastien Hébert

Professeur titulaire

sebastien.hebert@fmed.ulaval.ca

Département de psychiatrie et de neurosciences

Centre thématique de recherche en neurosciences

Centre de recherche du CHU de Québec - Université Laval

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Contribution à la recherche

Thématiques de recherche de la Faculté de médecine

Neurosciences et santé mentale

Projets de recherche en cours

Consortium pour l’identification précoce de la maladie d’Alzheimer (CIMA-Q) : renforcer l’intersectorialité, le rayonnement et le potentiel de découverte. - Fonds de recherche du Québec - Santé - Plateforme de financements de la recherche intersectorielle sur le vieillissement, co-chercheur - 2024-04-01 au 2028-03-31
Preclinical safety, pharmacokinetics, pharmacodynamics, and efficiency of microRNA oligonucleotides for Alzheimer's disease - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2022-04-01 au 2027-03-31
Vascular MicroRNA-212 in CAA and Alzheimer's disease - National Institute of Health (USA), Temple University, co-chercheur - 2023-09-22 au 2025-08-31

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Financements des 2 dernières années

Importance of non-canonical microRNAs in the mammalian brain - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC), Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2020-04-01 au 2025-03-31
Preclinical safety, pharmacokinetics, pharmacodynamics, and efficiency of microRNA oligonucleotides for Alzheimer's disease - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2020-03-01 au 2025-03-31

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Publications

Preclinical evaluation of miR-15/107 family members as multifactorial drug targets for Alzheimer's disease, Hébert, S.S., Dorval, V., Goupil, C., Smith, P.Y., Parsi, S., Molecular Therapy - Nucleic Acids, 2015, 10.1038/mtna.2015.33
LRRK2 in transcription and translation regulation: Relevance for Parkinson's disease, Hébert, S.S., Dorval, V., Frontiers in Neurology, 2012, 10.3389/fneur.2012.00012
MicroRNAs in Alzheimer's disease, Hébert, S.S., Mandemakers, W., Delay, C., Neurobiology of Disease, 2012, 10.1016/j.nbd.2012.01.003
Tau hyperphosphorylation and deregulation of calcineurin inmousemodels of Huntington's disease, Planel, E., Samadi, P., Parker, J.A., Cicchetti, F., Hébert, S.S., Whittington, R.A., Bissonnette, S., Poitras, i., Bezeau, F., Goupil, C., Dickler, M., Morin, F., Milot-Rousseau, P., Cisbani, G., Julien, C., Noël, A., Gratuze, M., Human Molecular Genetics, 2015, 10.1093/hmg/ddu456
MicroRNA regulation of Alzheimer's Amyloid precursor protein expression, De Strooper, B., Delacourte, A., Papadopoulou, A.S., Bergmans, B., Nicolaï, L., Horré, K., Hébert, S.S., Neurobiology of Disease, 2009, 10.1016/j.nbd.2008.11.009
The mixed lineage kinase DLK is oligomerized by tissue transglutaminase during apoptosis, Blouin, R., Aubin, R.A., Latreille, M., Grondin, G., Daviau, A., Hebert, S.S., Journal of Biological Chemistry, 2000
Up-regulation of inositol 1,4,5-trisphosphate receptor type 1 is responsible for a decreased endoplasmic-reticulum Ca²⁺ content in presenilin double knock-out cells, De Smedt, H., Missiaen, L., Parys, J.B., Callewaert, G., Hébert, S.S., Verbert, L., Kocks, S.L., Kasri, N.N., Cell Calcium, 2006, 10.1016/j.ceca.2006.03.005
The schizophrenia risk gene MIR137 acts as a hippocampal gene network node orchestrating the expression of genes relevant to nervous system development and function, Aschrafi, A., Martens, G.J.M., Kaplan, B.B., Hébert, S.S., van Bokhoven, H., Glennon, J.C., Nadif Kasri, N., Olde Loohuis, N.F.M., Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2017, 10.1016/j.pnpbp.2016.02.009
High-fat, high-sugar, and high-cholesterol consumption does not impact tau pathogenesis in a mouse model of Alzheimer's disease-like tau pathology, Planel, E., Marette, A., Hébert, S.S., Gratuze, M., Julien, J., Morin, F., Calon, F., Neurobiology of Aging, 2016, 10.1016/j.neurobiolaging.2016.07.016
Oligomerization of human presenilin-1 fragments, Lévesque, G., Godin, C., Hébert, S.S., FEBS Letters, 2003, 10.1016/S0014-5793(03)00813-5
MicroRNAs and the regulation of Tau metabolism, Buée, L., Sergeant, N., Hébert, S.S., International Journal of Alzheimer's Disease, 2012, 10.1155/2012/406561
Gene network and pathway analysis of mice with conditional ablation of dicer in post-mitotic neurons, Hébert, S.S., Buée, L., Zommer, N., Planel, E., Calvo, E., Delay, C., Smith, P.Y., Dorval, V., PLoS ONE, 2012, 10.1371/journal.pone.0044060
A simple method to avoid nonspecific signal when using monoclonal anti-tau antibodies in western blotting of mouse brain proteins, Planel, E., Hébert, S.S., Nicholls, S.B., Petry, F.R., Methods in Molecular Biology, 2017, 10.1007/978-1-4939-6598-4_15
Differential contribution of the three Aph1 genes to γ-secretase activity in vivo, De Strooper, B., Hartmann, D., Annaert, W., Zwijsen, A., Martens, G., Coolen, M., Hébert, S., Tousseyn, T., Jorissen, E., Horré, K., Craessaerts, K., Dejaegere, T., Serneels, L., Proceedings of the National Academy of Sciences of the United States of America, 2005, 10.1073/pnas.0408901102
Circulating microRNAs in Alzheimer's disease: The search for novel biomarkers, Hébert, S.S., Nelson, P.T., Dorval, V., Frontiers in Molecular Neuroscience, 2013, 10.3389/fnmol.2013.00024
Co-regulation of intragenic microRNA miR-153 and its host gene Ia-2 β: identification of miR-153 target genes with functions related to IA-2β in pancreas and brain, De Strooper, B., Notkins, A.L., Cai, T., Matta, S., Morais, V.A., Snellinx, A., Hébert, S.S., Caromile, L.A., Xu, H., Abuhatzira, L., Mandemakers, W., Diabetologia, 2013, 10.1007/s00125-013-2901-5
Targeting the HDAC2/HNF-4A/miR-101b/AMPK Pathway Rescues Tauopathy and Dendritic Abnormalities in Alzheimer's Disease, Zhu, L.-Q., Lu, Y., Chen, J.-G., Hébert, S.S., Wang, J.-Z., Fu, P., Wang, D.-Q., Zhou, Y.-F., Wang, X., Wei, N., Deng, M.-F., Li, X.-Y., Tang, H., Liu, D., Molecular Therapy, 2017, 10.1016/j.ymthe.2017.01.018
MicroRNA-132/212 deficiency enhances Aβ production and senile plaque deposition in Alzheimer's disease triple transgenic mice, Hébert, S.S., Cicchetti, F., Calon, F., Droit, A., Planel, E., Vallée, M., Saint-Pierre, M., Smith, P.Y., Dorval, V., Goupil, C., Rainone, S., Hernandez-Rapp, J., Scientific Reports, 2016, 10.1038/srep30953
Presenilin-1 interacts directly with the β-site amyloid protein precursor cleaving enzyme (BACE1), Lévesque, G., Carreau, M., Ferland, M., Godin, C., Bourdages, V., Hébert, S.S., Neurobiology of Disease, 2003, 10.1016/S0969-9961(03)00035-4
The amyloid-β precursor protein: Integrating structure with biological function, De Strooper, B., Hébert, S.S., Reinhard, C., EMBO Journal, 2005, 10.1038/sj.emboj.7600860
MicroRNAs underlying memory deficits in neurodegenerative disorders, Hébert, S.S., Rainone, S., Hernandez-Rapp, J., Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2017, 10.1016/j.pnpbp.2016.04.011
Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes, De Strooper, B., Müller, U., Filippov, M.A., Derks, C., Craessaerts, K., Tolia, A., Serneels, L., Hébert, S.S., EMBO Reports, 2006, 10.1038/sj.embor.7400704
Dimerization of presenilin-1 in vivo: Suggestion of novel regulatory mechanisms leading to higher order complexes, Lévesque, G., Mori, H., Tomiyama, T., Godin, C., Hébert, S.S., Biochemical and Biophysical Research Communications, 2003, 10.1016/S0006-291X(02)02984-4
Deregulation of protein phosphatase 2A and hyperphosphorylation of τ protein following onset of diabetes in NOD mice, Planel, E., Hébert, S.S., Mathews, P.M., Amrani, A., Gaudreau, S., Petry, F.R., Bretteville, A., Morin, F., Julien, C., Marcouiller, F., El Khoury, N.B., Papon, M.-A., Diabetes, 2013, 10.2337/db12-0187
Hypothermia mediates age-dependent increase of tau phosphorylation in db/db mice, Planel, E., Marette, A., Hébert, S.S., Calon, F., Nicholls, S.B., Morin, F., Marcouiller, F., Julien, C., Papon, M.-A., Petry, F., Gratuze, M., El Khoury, N.B., Neurobiology of Disease, 2016, 10.1016/j.nbd.2016.01.005
The miR-15/107 group of MicroRNA genes: Evolutionary biology, cellular functions, and roles in human diseases, Nelson, P.T., Mao, G., Wilfred, B.R., Hébert, S.S., Wang, W.-X., Finnerty, J.R., Journal of Molecular Biology, 2010, 10.1016/j.jmb.2010.07.051
Specificity of anti-Tau antibodies when analyzing mice models of Alzheimer's disease: Problems and solutions, Planel, E., Whittington, R.A., H́ebert, S.S., Calon, F., Morin, F., Bretteville, A., Pelletier, J., Petry, F.R., PLoS ONE, 2014, 10.1371/journal.pone.0094251
Increased AICD generation does not result in increased nuclear translocation or activation of target gene transcription, Pietrzik, C.U., De Strooper, B., Weggen, S., Behl, C., Hébert, S.S., Martin, A.M., Jaeger, S., Isbert, S., Kern, A., Waldron, E., Experimental Cell Research, 2008, 10.1016/j.yexcr.2008.05.003
Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain, Hassan, B.A., De Strooper, B., Reeve, S., Hébert, S.S., Ayaz, D., Leyssen, M., EMBO Journal, 2005, 10.1038/sj.emboj.7600757
MicroRNA-132 loss is associated with tau exon 10 inclusion in progressive supranuclear palsy, Hébert, S.S., Buée, L., Sergeant, N., Planel, E., Papon, M.l., Girard, J., Delay, C., Smith, P.Y., Human Molecular Genetics, 2011, 10.1093/hmg/ddr330
In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs, Hébert, S.S., Delay, C., Girard, J., Al Hashimi, A., Smith, P., Journal of Neurochemistry, 2011, 10.1111/j.1471-4159.2010.07097.x
Presenilin-I is indirectly implicated in Notchl cleavage, Lévesque, G., Carreau, M., Hébert, S.S., Ferland, M., Auclair, A., Godin, C., NeuroReport, 2003, 10.1097/00001756-200308260-00014
Studying microRNAs in the brain: Technical lessons learned from the first ten years, Nelson, P.T., Hébert, S.S., Experimental Neurology, 2012, 10.1016/j.expneurol.2011.12.004
Gene and microRNA transcriptome analysis of Parkinson's related LRRK2 mouse models, Hébert, S.S., De Strooper, B., Mazroui, R., Coudert, L., Jolivette, F., Mandemakers, W., Dorval, V., PLoS ONE, 2014, 10.1371/journal.pone.0085510
Coordinated and widespread expression of γ-secretase in vivo: Evidence for size and molecular heterogeneity, De Strooper, B., Hartmann, D., Annaert, W., Baert, V., Dabrowski, M., Horré, K., Dejaegere, T., Serneels, L., Hébert, S.S., Neurobiology of Disease, 2004, 10.1016/j.nbd.2004.08.002
Genetic ablation of dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration, de Strooper, B., Buée, L., Sergeant, N., Silahtaroglu, A.N., Planel, E., Galas, M.-C., Smith, P., Papadopoulou, A.S., Hébert, S.S., Human Molecular Genetics, 2010, 10.1093/hmg/ddq311
The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the golgi/endosomes protein network, Faure, R.L., Landry, C.R., Kelly, I., Hébert, S.S., Fortier, S., Collard-Simard, G., Boutchueng-Djidjou, M., Molecular and Cellular Proteomics, 2015, 10.1074/mcp.M114.047159
Alzheimer-specific variants in the 3'UTR of Amyloid precursor protein affect microRNA function, Hébert, S.S., Mathews, P., Calon, F., Delay, C., Molecular Neurodegeneration, 2011, 10.1186/1750-1326-6-70
Striatal pre-enkephalin overexpression improves Huntington's disease symptoms in the R6/2 mouse model of Huntington's disease., Samadi, P., Drolet, G., Hébert, S.S., Vaillancourt, M., Bissonnette, S., PloS one, 2013
Dimethyl sulfoxide induces both direct and indirect Tau hyperphosphorylation, Planel, E., Hébert, S.S., Baillargeon, J., El Khoury, N.B., Bretteville, A., Marcouiller, F., Julien, C., PLoS ONE, 2012, 10.1371/journal.pone.0040020
Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression, De Strooper, B., Delacourte, A., Kauppinen, S., Silahtaroglu, A.N., Mandemakers, W., Papadopoulou, A.S., Nicolaï, L., Horré, K., Hébert, S.S., Proceedings of the National Academy of Sciences of the United States of America, 2008, 10.1073/pnas.0710263105
Epigenetic control of aquaporin 1 expression by the amyloid precursor protein, Octave, J.-N., De Strooper, B., Brion, J.-P., Devuyst, O., Leroy, K., Tasiaux, B., Hébert, S., Kienlen-Campard, P., Huysseune, S., FASEB Journal, 2009, 10.1096/fj.09-140012
The effect of striatal pre-enkephalin overexpression in the basal ganglia of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease, Samadi, P., Hébert, S.S., Calon, F., Bezeau, F., Vernoux, N., Muratot, S., Bissonnette, S., European Journal of Neuroscience, 2014, 10.1111/ejn.12596
Molecular biology: miRNAs in neurodegeneration, De Strooper, B., Hébert, S.S., Science, 2007, 10.1126/science.1148530
Deficiency of the miR-29a/b-1 cluster leads to ataxic features and cerebellar alterations in mice, De Strooper, B., Glatzel, M., D'Hooge, R., Liston, A., Silahtaroglu, A., Hébert, S.S., Neumann, M., Spinazzi, M., Radaelli, E., Ayoubi, T., Lau, P., Dooley, J., Callaerts-Vegh, Z., Mandemakers, W., Achsel, T., Serneels, L., Papadopoulou, A.S., Neurobiology of Disease, 2015, 10.1016/j.nbd.2014.10.006
MicroRNAs targeting Nicastrin regulate Aβ production and are affected by target site polymorphisms, Hébert, S.S., Hsiung, G.-Y., Lambert, J.-C., Grenier-Boley, B., Fok, A., Dorval, V., Delay, C., Frontiers in Molecular Neuroscience, 2014, 10.3389/fnmol.2014.00067
MicroRNAs and Alzheimer's disease mouse models: Current insights and future research avenues, Delay, C., Hébert, S.S., International Journal of Alzheimer's Disease, 2011, 10.4061/2011/894938
Extracellular Na⁺ levels regulate formation and activity of the Nax/alpha1-Na⁺/K⁺ -ATPase complex in neuronal cells, Drolet, G., Mouginot, D., Toth, K., Hebert, S.S., Soulet, D., Henry, M., Smith, P.Y., Berret, E., Frontiers in Cellular Neuroscience, 2014, 10.3389/fncel.2014.00413
MiR-132/212 deficiency impairs tau metabolism and promotes pathological aggregation in vivo, Hébert, S.S., Calon, F., Tremblay, M.È., Buée, L., Sergeant, N., Fernandez-Gomez, F.-J., Bennett, D.A., Planel, E., Morin, F., Parsi, S., Dorval, V., Goupil, C., Bisht, K., Lecours, C., Jolivette, F., Hernandez-Rapp, J., Smith, P.Y., Human Molecular Genetics, 2015, 10.1093/hmg/ddv377
Alterations of the microRNA network cause neurodegenerative disease, De Strooper, B., Hébert, S.S., Trends in Neurosciences, 2009, 10.1016/j.tins.2008.12.003
Memory formation and retention are affected in adult miR-132/212 knockout mice, Hébert, S.S., Goodman, R.H., Planel, E., Magill, S.T., Goupil, C., Filali, M., Smith, P.Y., Hernandez-Rapp, J., Behavioural Brain Research, 2015, 10.1016/j.bbr.2015.03.032
Alzheimer research forum live discussion: Non-coding RNAs in neurodegeneration, Xu, G., Wang, W.-X., Umansky, S., Turner, L., Townsend, M., Stanek, L., Smalheiser, N., Perry, R., Nelson, P., Neilson, J., Muresan, V., Mizumoto, L., Maloney, B., Long, J., Kosik, K., Kinoshita, J., Hebert, S., Hayashi, M., Frederikse, P., Cuellar, T., Chang, R., Chai, X., Cashikar, A., Breen, G., Albensi, B., Journal of Alzheimer's Disease, 2009, 10.3233/JAD-2009-1007
Hypothermia-induced hyperphosphorylation: A new model to study tau kinase inhibitors, Planel, E., Hébert, S.S., Lévesque, G., Mouginot, D., Poitras, I., Petry, F.R., El Khoury, N.B., Julien, C., Marcouiller, F., Bretteville, A., Scientific Reports, 2012, 10.1038/srep00480
Mutation in the 3'untranslated region of APP as a genetic determinant of cerebral amyloid angiopathy, Rovelet-Lecrux, A., Hébert, S.S., Tournier-Lasserve, E., Hannequin, D., Campion, D., Frebourg, T., Preux, P.-M., Lambert, J.-C., Dartigues, J.-F., Mbelesso, P., Ndamba-Bandzouzi, B., Guerchet, M., Amouyel, P., Hervé, D., Riant, F., Sarov-Rivière, M., Dorval, V., Pottier, C., Richard, A.-C., Goupil, C., Wallon, D., Nicolas, G., European Journal of Human Genetics, 2016, 10.1038/ejhg.2015.61
A study of small RNAs from cerebral neocortex of pathology-verified Alzheimer's disease, dementia with lewy bodies, hippocampal sclerosis, frontotemporal lobar dementia, and non-demented human controls, Nelson, P.T., Zhu, Q., Wang, W.-X., Hébert, S.S., Journal of Alzheimer's Disease, 2013, 10.3233/JAD-122350
Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis, Vassar, R., Bennett, D.A., Haass, C., De Strooper, B., Hébert, S.S., Lichtenthaler, S.F., Lammich, S., Bembinster, L.A., Hitt, B., Eimer, W.A., Cole, S.L., Zhao, J., Velliquette, R.A., Maus, E., Sadleir, K.R., O'Connor, T., Neuron, 2008, 10.1016/j.neuron.2008.10.047

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Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2020/07

Gabriel Boulay - Maîtrise avec mémoire - En cours
Mohamed Amir Kezai - Post-doctorat - En cours
Mohamed Lala Bouali - Doctorat - En cours
Véronique Lévesque - Maîtrise avec mémoire - En cours
Nasim Eskandari - Doctorat - En cours
Boutheyna Khelaifia - Doctorat - En cours
Serena Petry - Post-doctorat - En cours
Rémi Keraudren - Maîtrise avec mémoire - 2023/09
Behnaz Nateghi - Doctorat - 2024/05
Malia Bouaziz - Maîtrise avec mémoire - 2025/01

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Biologie cellulaire et moléculaire
Neurobiologie — Neurosciences

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.

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