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Sébastien Hébert

Professeur titulaire

sebastien.hebert@fmed.ulaval.ca
Centre thématique de recherche en neurosciences
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Neurosciences et santé mentale

Domaines et intérêts de recherche du (de la) professeur(e) :

Neurosciences, santé mentale et toxicomanies
  • Maladie d'Alzheimer
  • Maladies neurodégénératives
  • Chorée de Huntington

Projets de recherche

  • Consortium pour l’identification précoce de la maladie d’Alzheimer (CIMA-Q) : renforcer l’intersectorialité, le rayonnement et le potentiel de découverte. - Fonds de recherche du Québec - Santé - Plateforme de financements de la recherche intersectorielle sur le vieillissement, co-chercheur - 2024-04-01 au 2028-03-31
  • Preclinical safety, pharmacokinetics, pharmacodynamics, and efficiency of microRNA oligonucleotides for Alzheimer's disease - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2022-04-01 au 2027-03-31
  • Vascular MicroRNA-212 in CAA and Alzheimer's disease - National Institute of Health (USA), Temple University, co-chercheur - 2023-09-22 au 2025-08-31
  • Importance of non-canonical microRNAs in the mammalian brain - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC), Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2020-04-01 au 2025-03-31
  • Preclinical safety, pharmacokinetics, pharmacodynamics, and efficiency of microRNA oligonucleotides for Alzheimer's disease - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2020-03-01 au 2025-03-31
  • Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
  • Salaire d'un professeur sous octroi - CHU de Québec – Université Laval – CHUL, chercheur principal - 2009-02-01 au 2022-06-30
  • Étude in vivo des microARNs dans les maladies neurodégénératives - Fonds de recherche du Québec - Santé - Chercheur-boursier Juniors 1 et 2, Seniors, chercheur principal - 2019-07-01 au 2022-06-30

Publications

  • The mixed lineage kinase DLK is oligomerized by tissue transglutaminase during apoptosis, Blouin, R., Aubin, R.A., Latreille, M., Grondin, G., Daviau, A., Hebert, S.S., Journal of Biological Chemistry, 2000
  • Hypothermia mediates age-dependent increase of tau phosphorylation in db/db mice, Planel, E., Marette, A., Hébert, S.S., Calon, F., Nicholls, S.B., Morin, F., Marcouiller, F., Julien, C., Papon, M.-A., Petry, F., Gratuze, M., El Khoury, N.B., Neurobiology of Disease, 2016, 10.1016/j.nbd.2016.01.005
  • MicroRNAs underlying memory deficits in neurodegenerative disorders, Hébert, S.S., Rainone, S., Hernandez-Rapp, J., Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2017, 10.1016/j.pnpbp.2016.04.011
  • High-fat, high-sugar, and high-cholesterol consumption does not impact tau pathogenesis in a mouse model of Alzheimer's disease-like tau pathology, Planel, E., Marette, A., Hébert, S.S., Calon, F., Morin, F., Julien, J., Gratuze, M., Neurobiology of Aging, 2016, 10.1016/j.neurobiolaging.2016.07.016
  • Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis, Vassar, R., Bennett, D.A., Haass, C., De Strooper, B., Hébert, S.S., Lichtenthaler, S.F., Lammich, S., Bembinster, L.A., Hitt, B., Eimer, W.A., Cole, S.L., Zhao, J., Velliquette, R.A., Maus, E., Sadleir, K.R., O'Connor, T., Neuron, 2008, 10.1016/j.neuron.2008.10.047
  • Studying microRNAs in the brain: Technical lessons learned from the first ten years, Nelson, P.T., Hébert, S.S., Experimental Neurology, 2012, 10.1016/j.expneurol.2011.12.004
  • Presenilin-1 interacts directly with the β-site amyloid protein precursor cleaving enzyme (BACE1), Lévesque, G., Carreau, M., Ferland, M., Godin, C., Bourdages, V., Hébert, S.S., Neurobiology of Disease, 2003, 10.1016/S0969-9961(03)00035-4
  • The effect of striatal pre-enkephalin overexpression in the basal ganglia of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease, Samadi, P., Hébert, S.S., Calon, F., Bezeau, F., Vernoux, N., Muratot, S., Bissonnette, S., European Journal of Neuroscience, 2014, 10.1111/ejn.12596
  • Memory formation and retention are affected in adult miR-132/212 knockout mice, Hébert, S.S., Goodman, R.H., Magill, S.T., Planel, E., Goupil, C., Filali, M., Smith, P.Y., Hernandez-Rapp, J., Behavioural Brain Research, 2015, 10.1016/j.bbr.2015.03.032
  • Increased AICD generation does not result in increased nuclear translocation or activation of target gene transcription, Pietrzik, C.U., De Strooper, B., Weggen, S., Behl, C., Hébert, S.S., Martin, A.M., Jaeger, S., Kern, A., Isbert, S., Waldron, E., Experimental Cell Research, 2008, 10.1016/j.yexcr.2008.05.003
  • MicroRNA-132/212 deficiency enhances Aβ production and senile plaque deposition in Alzheimer's disease triple transgenic mice, Hébert, S.S., Cicchetti, F., Calon, F., Droit, A., Planel, E., Vallée, M., Saint-Pierre, M., Smith, P.Y., Dorval, V., Goupil, C., Rainone, S., Hernandez-Rapp, J., Scientific Reports, 2016, 10.1038/srep30953
  • Differential contribution of the three Aph1 genes to γ-secretase activity in vivo, De Strooper, B., Hartmann, D., Annaert, W., Zwijsen, A., Martens, G., Coolen, M., Hébert, S., Tousseyn, T., Jorissen, E., Horré, K., Craessaerts, K., Dejaegere, T., Serneels, L., Proceedings of the National Academy of Sciences of the United States of America, 2005, 10.1073/pnas.0408901102
  • The miR-15/107 group of MicroRNA genes: Evolutionary biology, cellular functions, and roles in human diseases, Nelson, P.T., Mao, G., Wilfred, B.R., Hébert, S.S., Wang, W.-X., Finnerty, J.R., Journal of Molecular Biology, 2010, 10.1016/j.jmb.2010.07.051
  • Circulating microRNAs in Alzheimer's disease: The search for novel biomarkers, Hébert, S.S., Nelson, P.T., Dorval, V., Frontiers in Molecular Neuroscience, 2013, 10.3389/fnmol.2013.00024
  • Deficiency of the miR-29a/b-1 cluster leads to ataxic features and cerebellar alterations in mice, De Strooper, B., Glatzel, M., D'Hooge, R., Liston, A., Silahtaroglu, A., Hébert, S.S., Neumann, M., Spinazzi, M., Radaelli, E., Ayoubi, T., Lau, P., Dooley, J., Callaerts-Vegh, Z., Mandemakers, W., Achsel, T., Serneels, L., Papadopoulou, A.S., Neurobiology of Disease, 2015, 10.1016/j.nbd.2014.10.006
  • The amyloid-β precursor protein: Integrating structure with biological function, De Strooper, B., Hébert, S.S., Reinhard, C., EMBO Journal, 2005, 10.1038/sj.emboj.7600860
  • Gene and microRNA transcriptome analysis of Parkinson's related LRRK2 mouse models, Hébert, S.S., De Strooper, B., Mazroui, R., Coudert, L., Jolivette, F., Mandemakers, W., Dorval, V., PLoS ONE, 2014, 10.1371/journal.pone.0085510
  • The schizophrenia risk gene MIR137 acts as a hippocampal gene network node orchestrating the expression of genes relevant to nervous system development and function, Aschrafi, A., Martens, G.J.M., Kaplan, B.B., Hébert, S.S., van Bokhoven, H., Glennon, J.C., Nadif Kasri, N., Olde Loohuis, N.F.M., Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2017, 10.1016/j.pnpbp.2016.02.009
  • Dimerization of presenilin-1 in vivo: Suggestion of novel regulatory mechanisms leading to higher order complexes, Lévesque, G., Mori, H., Tomiyama, T., Godin, C., Hébert, S.S., Biochemical and Biophysical Research Communications, 2003, 10.1016/S0006-291X(02)02984-4
  • Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain, Hassan, B.A., De Strooper, B., Reeve, S., Hébert, S.S., Ayaz, D., Leyssen, M., EMBO Journal, 2005, 10.1038/sj.emboj.7600757
  • Alzheimer-specific variants in the 3'UTR of Amyloid precursor protein affect microRNA function, Hébert, S.S., Mathews, P., Calon, F., Delay, C., Molecular Neurodegeneration, 2011, 10.1186/1750-1326-6-70
  • Striatal pre-enkephalin overexpression improves Huntington's disease symptoms in the R6/2 mouse model of Huntington's disease., Samadi, P., Drolet, G., Hébert, S.S., Vaillancourt, M., Bissonnette, S., PloS one, 2013
  • Molecular biology: miRNAs in neurodegeneration, De Strooper, B., Hébert, S.S., Science, 2007, 10.1126/science.1148530
  • Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes, De Strooper, B., Müller, U., Filippov, M.A., Derks, C., Craessaerts, K., Tolia, A., Serneels, L., Hébert, S.S., EMBO Reports, 2006, 10.1038/sj.embor.7400704
  • MiR-132/212 deficiency impairs tau metabolism and promotes pathological aggregation in vivo, Hébert, S.S., Calon, F., Tremblay, M.È., Buée, L., Sergeant, N., Fernandez-Gomez, F.-J., Bennett, D.A., Planel, E., Morin, F., Parsi, S., Dorval, V., Goupil, C., Bisht, K., Lecours, C., Jolivette, F., Hernandez-Rapp, J., Smith, P.Y., Human Molecular Genetics, 2015, 10.1093/hmg/ddv377
  • Targeting the HDAC2/HNF-4A/miR-101b/AMPK Pathway Rescues Tauopathy and Dendritic Abnormalities in Alzheimer's Disease, Zhu, L.-Q., Lu, Y., Chen, J.-G., Hébert, S.S., Wang, J.-Z., Fu, P., Wang, D.-Q., Zhou, Y.-F., Wang, X., Wei, N., Deng, M.-F., Li, X.-Y., Tang, H., Liu, D., Molecular Therapy, 2017, 10.1016/j.ymthe.2017.01.018
  • Alzheimer research forum live discussion: Non-coding RNAs in neurodegeneration, Xu, G., Wang, W.-X., Umansky, S., Turner, L., Townsend, M., Stanek, L., Smalheiser, N., Perry, R., Nelson, P., Neilson, J., Muresan, V., Mizumoto, L., Maloney, B., Long, J., Kosik, K., Kinoshita, J., Hebert, S., Hayashi, M., Frederikse, P., Cuellar, T., Chang, R., Chai, X., Cashikar, A., Breen, G., Albensi, B., Journal of Alzheimer's Disease, 2009, 10.3233/JAD-2009-1007
  • Epigenetic control of aquaporin 1 expression by the amyloid precursor protein, Octave, J.-N., De Strooper, B., Brion, J.-P., Devuyst, O., Leroy, K., Tasiaux, B., Hébert, S., Kienlen-Campard, P., Huysseune, S., FASEB Journal, 2009, 10.1096/fj.09-140012
  • Presenilin-I is indirectly implicated in Notchl cleavage, Lévesque, G., Carreau, M., Hébert, S.S., Ferland, M., Auclair, A., Godin, C., NeuroReport, 2003, 10.1097/00001756-200308260-00014
  • A simple method to avoid nonspecific signal when using monoclonal anti-tau antibodies in western blotting of mouse brain proteins, Planel, E., Hébert, S.S., Nicholls, S.B., Petry, F.R., Methods in Molecular Biology, 2017, 10.1007/978-1-4939-6598-4_15
  • Genetic ablation of dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration, de Strooper, B., Buée, L., Sergeant, N., Silahtaroglu, A.N., Planel, E., Galas, M.-C., Smith, P., Papadopoulou, A.S., Hébert, S.S., Human Molecular Genetics, 2010, 10.1093/hmg/ddq311
  • MicroRNA regulation of Alzheimer's Amyloid precursor protein expression, De Strooper, B., Delacourte, A., Papadopoulou, A.S., Bergmans, B., Nicolaï, L., Horré, K., Hébert, S.S., Neurobiology of Disease, 2009, 10.1016/j.nbd.2008.11.009
  • Tau hyperphosphorylation and deregulation of calcineurin inmousemodels of Huntington's disease, Planel, E., Samadi, P., Parker, J.A., Cicchetti, F., Hébert, S.S., Whittington, R.A., Bissonnette, S., Poitras, i., Bezeau, F., Goupil, C., Dickler, M., Morin, F., Milot-Rousseau, P., Cisbani, G., Julien, C., Noël, A., Gratuze, M., Human Molecular Genetics, 2015, 10.1093/hmg/ddu456
  • Dimethyl sulfoxide induces both direct and indirect Tau hyperphosphorylation, Planel, E., Hébert, S.S., Baillargeon, J., El Khoury, N.B., Bretteville, A., Marcouiller, F., Julien, C., PLoS ONE, 2012, 10.1371/journal.pone.0040020
  • Specificity of anti-Tau antibodies when analyzing mice models of Alzheimer's disease: Problems and solutions, Planel, E., Whittington, R.A., H́ebert, S.S., Calon, F., Morin, F., Bretteville, A., Pelletier, J., Petry, F.R., PLoS ONE, 2014, 10.1371/journal.pone.0094251
  • MicroRNAs and Alzheimer's disease mouse models: Current insights and future research avenues, Delay, C., Hébert, S.S., International Journal of Alzheimer's Disease, 2011, 10.4061/2011/894938
  • Mutation in the 3'untranslated region of APP as a genetic determinant of cerebral amyloid angiopathy, Rovelet-Lecrux, A., Hébert, S.S., Tournier-Lasserve, E., Hannequin, D., Campion, D., Frebourg, T., Preux, P.-M., Lambert, J.-C., Dartigues, J.-F., Mbelesso, P., Ndamba-Bandzouzi, B., Guerchet, M., Amouyel, P., Hervé, D., Riant, F., Sarov-Rivière, M., Dorval, V., Pottier, C., Richard, A.-C., Goupil, C., Wallon, D., Nicolas, G., European Journal of Human Genetics, 2016, 10.1038/ejhg.2015.61
  • LRRK2 in transcription and translation regulation: Relevance for Parkinson's disease, Hébert, S.S., Dorval, V., Frontiers in Neurology, 2012, 10.3389/fneur.2012.00012
  • Co-regulation of intragenic microRNA miR-153 and its host gene Ia-2 β: identification of miR-153 target genes with functions related to IA-2β in pancreas and brain, De Strooper, B., Notkins, A.L., Cai, T., Matta, S., Morais, V.A., Snellinx, A., Hébert, S.S., Caromile, L.A., Xu, H., Abuhatzira, L., Mandemakers, W., Diabetologia, 2013, 10.1007/s00125-013-2901-5
  • MicroRNA-132 loss is associated with tau exon 10 inclusion in progressive supranuclear palsy, Hébert, S.S., Buée, L., Sergeant, N., Planel, E., Papon, M.l., Girard, J., Delay, C., Smith, P.Y., Human Molecular Genetics, 2011, 10.1093/hmg/ddr330
  • The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the golgi/endosomes protein network, Faure, R.L., Landry, C.R., Kelly, I., Hébert, S.S., Fortier, S., Collard-Simard, G., Boutchueng-Djidjou, M., Molecular and Cellular Proteomics, 2015, 10.1074/mcp.M114.047159
  • A study of small RNAs from cerebral neocortex of pathology-verified Alzheimer's disease, dementia with lewy bodies, hippocampal sclerosis, frontotemporal lobar dementia, and non-demented human controls, Nelson, P.T., Zhu, Q., Wang, W.-X., Hébert, S.S., Journal of Alzheimer's Disease, 2013, 10.3233/JAD-122350
  • MicroRNAs targeting Nicastrin regulate Aβ production and are affected by target site polymorphisms, Hébert, S.S., Hsiung, G.-Y., Lambert, J.-C., Grenier-Boley, B., Fok, A., Dorval, V., Delay, C., Frontiers in Molecular Neuroscience, 2014, 10.3389/fnmol.2014.00067
  • Coordinated and widespread expression of γ-secretase in vivo: Evidence for size and molecular heterogeneity, De Strooper, B., Hartmann, D., Annaert, W., Baert, V., Dabrowski, M., Horré, K., Dejaegere, T., Serneels, L., Hébert, S.S., Neurobiology of Disease, 2004, 10.1016/j.nbd.2004.08.002
  • Hypothermia-induced hyperphosphorylation: A new model to study tau kinase inhibitors, Planel, E., Hébert, S.S., Lévesque, G., Mouginot, D., Poitras, I., Petry, F.R., El Khoury, N.B., Julien, C., Marcouiller, F., Bretteville, A., Scientific Reports, 2012, 10.1038/srep00480
  • Alterations of the microRNA network cause neurodegenerative disease, De Strooper, B., Hébert, S.S., Trends in Neurosciences, 2009, 10.1016/j.tins.2008.12.003
  • Deregulation of protein phosphatase 2A and hyperphosphorylation of τ protein following onset of diabetes in NOD mice, Planel, E., Hébert, S.S., Mathews, P.M., Amrani, A., Gaudreau, S., Petry, F.R., Bretteville, A., Morin, F., Julien, C., Marcouiller, F., El Khoury, N.B., Papon, M.-A., Diabetes, 2013, 10.2337/db12-0187
  • Gene network and pathway analysis of mice with conditional ablation of dicer in post-mitotic neurons, Hébert, S.S., Buée, L., Zommer, N., Planel, E., Calvo, E., Delay, C., Smith, P.Y., Dorval, V., PLoS ONE, 2012, 10.1371/journal.pone.0044060
  • Up-regulation of inositol 1,4,5-trisphosphate receptor type 1 is responsible for a decreased endoplasmic-reticulum Ca2+ content in presenilin double knock-out cells, De Smedt, H., Missiaen, L., Parys, J.B., Callewaert, G., Hébert, S.S., Verbert, L., Kocks, S.L., Kasri, N.N., Cell Calcium, 2006, 10.1016/j.ceca.2006.03.005
  • MicroRNAs in Alzheimer's disease, Hébert, S.S., Mandemakers, W., Delay, C., Neurobiology of Disease, 2012, 10.1016/j.nbd.2012.01.003
  • Extracellular Na+ levels regulate formation and activity of the Nax/alpha1-Na+/K+ -ATPase complex in neuronal cells, Drolet, G., Mouginot, D., Toth, K., Hebert, S.S., Soulet, D., Henry, M., Smith, P.Y., Berret, E., Frontiers in Cellular Neuroscience, 2014, 10.3389/fncel.2014.00413
  • Preclinical evaluation of miR-15/107 family members as multifactorial drug targets for Alzheimer's disease, Hébert, S.S., Dorval, V., Goupil, C., Smith, P.Y., Parsi, S., Molecular Therapy - Nucleic Acids, 2015, 10.1038/mtna.2015.33
  • Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression, De Strooper, B., Delacourte, A., Kauppinen, S., Silahtaroglu, A.N., Mandemakers, W., Papadopoulou, A.S., Nicolaï, L., Horré, K., Hébert, S.S., Proceedings of the National Academy of Sciences of the United States of America, 2008, 10.1073/pnas.0710263105
  • Oligomerization of human presenilin-1 fragments, Lévesque, G., Godin, C., Hébert, S.S., FEBS Letters, 2003, 10.1016/S0014-5793(03)00813-5
  • MicroRNAs and the regulation of Tau metabolism, Buée, L., Sergeant, N., Hébert, S.S., International Journal of Alzheimer's Disease, 2012, 10.1155/2012/406561
  • In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs, Hébert, S.S., Delay, C., Girard, J., Al Hashimi, A., Smith, P., Journal of Neurochemistry, 2011, 10.1111/j.1471-4159.2010.07097.x

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Boutheyna Khelaifia - Doctorat - En cours
  • Mohamed Amir Kezai - Post-doctorat - En cours
  • Gabriel Boulay - Maîtrise avec mémoire - En cours
  • Mohamed Lala Bouali - Doctorat - En cours
  • Behnaz Nateghi - Doctorat - En cours
  • Pascal Smith - Maîtrise avec mémoire - 2014/05
  • Sepideh Parsi - Doctorat - 2016/05
  • Andréanne Turgeon - Maîtrise avec mémoire - 2018/05
  • Sara Rainone - Doctorat - 2018/09
  • Emmanuelle Boscher - Doctorat - 2020/01
  • Isabelle Guisle - Doctorat - 2020/01
  • Rémi Keraudren - Maîtrise avec mémoire - 2023/09

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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