Sébastien Hébert

Professeur titulaire

sebastien.hebert@fmed.ulaval.ca

Département de psychiatrie et de neurosciences

Centre thématique de recherche en neurosciences

Centre de recherche du CHU de Québec - Université Laval

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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Neurosciences et santé mentale

Domaines et intérêts de recherche du (de la) professeur(e) :

Neurosciences, santé mentale et toxicomanies

Maladie d'Alzheimer
Maladies neurodégénératives
Chorée de Huntington

Projets de recherche

Preclinical safety, pharmacokinetics, pharmacodynamics, and efficiency of microRNA oligonucleotides for Alzheimer's disease - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2022-04-01 au 2027-03-31
Preclinical safety, pharmacokinetics, pharmacodynamics, and efficiency of microRNA oligonucleotides for Alzheimer's disease - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2020-03-01 au 2025-03-31
Importance of non-canonical microRNAs in the mammalian brain - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC), Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2020-04-01 au 2025-03-31
Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
Étude in vivo des microARNs dans les maladies neurodégénératives - Fonds de recherche du Québec - Santé - Chercheur-boursier Juniors 1 et 2, Seniors, chercheur principal - 2019-07-01 au 2022-06-30
Salaire d'un professeur sous octroi - CHU de Québec – Université Laval – CHUL, chercheur principal - 2009-02-01 au 2022-06-30
microRNA-132: from underlying mechanism of neurodegeneration to therapeutic application in Huntington’s disease - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2017-04-01 au 2022-03-31
Importance of microRNA biogenesis deficits in Huntington’s disease (Serena Petry) - Huntington's Disease Society of America - Human Biology Project, chercheur principal - 2018-12-01 au 2020-12-01

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Publications

A simple method to avoid nonspecific signal when using monoclonal anti-tau antibodies in western blotting of mouse brain proteins, Petry, F.R., Nicholls, S.B., Hébert, S.S., Planel, E., Methods in Molecular Biology, 2017, 10.1007/978-1-4939-6598-4_15
MicroRNAs underlying memory deficits in neurodegenerative disorders, Hernandez-Rapp, J., Rainone, S., Hébert, S.S., Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2017, 10.1016/j.pnpbp.2016.04.011
Targeting the HDAC2/HNF-4A/miR-101b/AMPK Pathway Rescues Tauopathy and Dendritic Abnormalities in Alzheimer's Disease, Liu, D., Tang, H., Li, X.-Y., Deng, M.-F., Wei, N., Wang, X., Zhou, Y.-F., Wang, D.-Q., Fu, P., Wang, J.-Z., Hébert, S.S., Chen, J.-G., Lu, Y., Zhu, L.-Q., Molecular Therapy, 2017, 10.1016/j.ymthe.2017.01.018
The schizophrenia risk gene MIR137 acts as a hippocampal gene network node orchestrating the expression of genes relevant to nervous system development and function, Olde Loohuis, N.F.M., Nadif Kasri, N., Glennon, J.C., van Bokhoven, H., Hébert, S.S., Kaplan, B.B., Martens, G.J.M., Aschrafi, A., Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2017, 10.1016/j.pnpbp.2016.02.009
High-fat, high-sugar, and high-cholesterol consumption does not impact tau pathogenesis in a mouse model of Alzheimer's disease-like tau pathology, Gratuze, M., Julien, J., Morin, F., Calon, F., Hébert, S.S., Marette, A., Planel, E., Neurobiology of Aging, 2016, 10.1016/j.neurobiolaging.2016.07.016
Hypothermia mediates age-dependent increase of tau phosphorylation in db/db mice, El Khoury, N.B., Gratuze, M., Petry, F., Papon, M.-A., Julien, C., Marcouiller, F., Morin, F., Nicholls, S.B., Calon, F., Hébert, S.S., Marette, A., Planel, E., Neurobiology of Disease, 2016, 10.1016/j.nbd.2016.01.005
MicroRNA-132/212 deficiency enhances Aβ production and senile plaque deposition in Alzheimer's disease triple transgenic mice, Hernandez-Rapp, J., Rainone, S., Goupil, C., Dorval, V., Smith, P.Y., Saint-Pierre, M., Vallée, M., Planel, E., Droit, A., Calon, F., Cicchetti, F., Hébert, S.S., Scientific Reports, 2016, 10.1038/srep30953
Mutation in the 3'untranslated region of APP as a genetic determinant of cerebral amyloid angiopathy, Nicolas, G., Wallon, D., Goupil, C., Richard, A.-C., Pottier, C., Dorval, V., Sarov-Rivière, M., Riant, F., Hervé, D., Amouyel, P., Guerchet, M., Ndamba-Bandzouzi, B., Mbelesso, P., Dartigues, J.-F., Lambert, J.-C., Preux, P.-M., Frebourg, T., Campion, D., Hannequin, D., Tournier-Lasserve, E., Hébert, S.S., Rovelet-Lecrux, A., European Journal of Human Genetics, 2016, 10.1038/ejhg.2015.61
Deficiency of the miR-29a/b-1 cluster leads to ataxic features and cerebellar alterations in mice, Papadopoulou, A.S., Serneels, L., Achsel, T., Mandemakers, W., Callaerts-Vegh, Z., Dooley, J., Lau, P., Ayoubi, T., Radaelli, E., Spinazzi, M., Neumann, M., Hébert, S.S., Silahtaroglu, A., Liston, A., D'Hooge, R., Glatzel, M., De Strooper, B., Neurobiology of Disease, 2015, 10.1016/j.nbd.2014.10.006
Memory formation and retention are affected in adult miR-132/212 knockout mice, Hernandez-Rapp, J., Smith, P.Y., Filali, M., Goupil, C., Planel, E., Magill, S.T., Goodman, R.H., Hébert, S.S., Behavioural Brain Research, 2015, 10.1016/j.bbr.2015.03.032
MiR-132/212 deficiency impairs tau metabolism and promotes pathological aggregation in vivo, Smith, P.Y., Hernandez-Rapp, J., Jolivette, F., Lecours, C., Bisht, K., Goupil, C., Dorval, V., Parsi, S., Morin, F., Planel, E., Bennett, D.A., Fernandez-Gomez, F.-J., Sergeant, N., Buée, L., Tremblay, M.È., Calon, F., Hébert, S.S., Human Molecular Genetics, 2015, 10.1093/hmg/ddv377
Preclinical evaluation of miR-15/107 family members as multifactorial drug targets for Alzheimer's disease, Parsi, S., Smith, P.Y., Goupil, C., Dorval, V., Hébert, S.S., Molecular Therapy - Nucleic Acids, 2015, 10.1038/mtna.2015.33
Tau hyperphosphorylation and deregulation of calcineurin inmousemodels of Huntington's disease, Gratuze, M., Noël, A., Julien, C., Cisbani, G., Milot-Rousseau, P., Morin, F., Dickler, M., Goupil, C., Bezeau, F., Poitras, i., Bissonnette, S., Whittington, R.A., Hébert, S.S., Cicchetti, F., Parker, J.A., Samadi, P., Planel, E., Human Molecular Genetics, 2015, 10.1093/hmg/ddu456
The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the golgi/endosomes protein network, Boutchueng-Djidjou, M., Collard-Simard, G., Fortier, S., Hébert, S.S., Kelly, I., Landry, C.R., Faure, R.L., Molecular and Cellular Proteomics, 2015, 10.1074/mcp.M114.047159
Extracellular Na⁺ levels regulate formation and activity of the Nax/alpha1-Na⁺/K⁺ -ATPase complex in neuronal cells, Berret, E., Smith, P.Y., Henry, M., Soulet, D., Hebert, S.S., Toth, K., Mouginot, D., Drolet, G., Frontiers in Cellular Neuroscience, 2014, 10.3389/fncel.2014.00413
Gene and microRNA transcriptome analysis of Parkinson's related LRRK2 mouse models, Dorval, V., Mandemakers, W., Jolivette, F., Coudert, L., Mazroui, R., De Strooper, B., Hébert, S.S., PLoS ONE, 2014, 10.1371/journal.pone.0085510
MicroRNAs targeting Nicastrin regulate Aβ production and are affected by target site polymorphisms, Delay, C., Dorval, V., Fok, A., Grenier-Boley, B., Lambert, J.-C., Hsiung, G.-Y., Hébert, S.S., Frontiers in Molecular Neuroscience, 2014, 10.3389/fnmol.2014.00067
Specificity of anti-Tau antibodies when analyzing mice models of Alzheimer's disease: Problems and solutions, Petry, F.R., Pelletier, J., Bretteville, A., Morin, F., Calon, F., H́ebert, S.S., Whittington, R.A., Planel, E., PLoS ONE, 2014, 10.1371/journal.pone.0094251
The effect of striatal pre-enkephalin overexpression in the basal ganglia of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease, Bissonnette, S., Muratot, S., Vernoux, N., Bezeau, F., Calon, F., Hébert, S.S., Samadi, P., European Journal of Neuroscience, 2014, 10.1111/ejn.12596
A study of small RNAs from cerebral neocortex of pathology-verified Alzheimer's disease, dementia with lewy bodies, hippocampal sclerosis, frontotemporal lobar dementia, and non-demented human controls, Hébert, S.S., Wang, W.-X., Zhu, Q., Nelson, P.T., Journal of Alzheimer's Disease, 2013, 10.3233/JAD-122350
Circulating microRNAs in Alzheimer's disease: The search for novel biomarkers, Dorval, V., Nelson, P.T., Hébert, S.S., Frontiers in Molecular Neuroscience, 2013, 10.3389/fnmol.2013.00024
Co-regulation of intragenic microRNA miR-153 and its host gene Ia-2 β: identification of miR-153 target genes with functions related to IA-2β in pancreas and brain, Mandemakers, W., Abuhatzira, L., Xu, H., Caromile, L.A., Hébert, S.S., Snellinx, A., Morais, V.A., Matta, S., Cai, T., Notkins, A.L., De Strooper, B., Diabetologia, 2013, 10.1007/s00125-013-2901-5
Deregulation of protein phosphatase 2A and hyperphosphorylation of τ protein following onset of diabetes in NOD mice, Papon, M.-A., El Khoury, N.B., Marcouiller, F., Julien, C., Morin, F., Bretteville, A., Petry, F.R., Gaudreau, S., Amrani, A., Mathews, P.M., Hébert, S.S., Planel, E., Diabetes, 2013, 10.2337/db12-0187
Striatal pre-enkephalin overexpression improves Huntington's disease symptoms in the R6/2 mouse model of Huntington's disease., Bissonnette, S., Vaillancourt, M., Hébert, S.S., Drolet, G., Samadi, P., PloS one, 2013
Dimethyl sulfoxide induces both direct and indirect Tau hyperphosphorylation, Julien, C., Marcouiller, F., Bretteville, A., El Khoury, N.B., Baillargeon, J., Hébert, S.S., Planel, E., PLoS ONE, 2012, 10.1371/journal.pone.0040020
Gene network and pathway analysis of mice with conditional ablation of dicer in post-mitotic neurons, Dorval, V., Smith, P.Y., Delay, C., Calvo, E., Planel, E., Zommer, N., Buée, L., Hébert, S.S., PLoS ONE, 2012, 10.1371/journal.pone.0044060
Hypothermia-induced hyperphosphorylation: A new model to study tau kinase inhibitors, Bretteville, A., Marcouiller, F., Julien, C., El Khoury, N.B., Petry, F.R., Poitras, I., Mouginot, D., Lévesque, G., Hébert, S.S., Planel, E., Scientific Reports, 2012, 10.1038/srep00480
LRRK2 in transcription and translation regulation: Relevance for Parkinson's disease, Dorval, V., Hébert, S.S., Frontiers in Neurology, 2012, 10.3389/fneur.2012.00012
MicroRNAs and the regulation of Tau metabolism, Hébert, S.S., Sergeant, N., Buée, L., International Journal of Alzheimer's Disease, 2012, 10.1155/2012/406561
MicroRNAs in Alzheimer's disease, Delay, C., Mandemakers, W., Hébert, S.S., Neurobiology of Disease, 2012, 10.1016/j.nbd.2012.01.003
Studying microRNAs in the brain: Technical lessons learned from the first ten years, Hébert, S.S., Nelson, P.T., Experimental Neurology, 2012, 10.1016/j.expneurol.2011.12.004
Alzheimer-specific variants in the 3'UTR of Amyloid precursor protein affect microRNA function, Delay, C., Calon, F., Mathews, P., Hébert, S.S., Molecular Neurodegeneration, 2011, 10.1186/1750-1326-6-70
In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs, Smith, P., Al Hashimi, A., Girard, J., Delay, C., Hébert, S.S., Journal of Neurochemistry, 2011, 10.1111/j.1471-4159.2010.07097.x
MicroRNA-132 loss is associated with tau exon 10 inclusion in progressive supranuclear palsy, Smith, P.Y., Delay, C., Girard, J., Papon, M.l., Planel, E., Sergeant, N., Buée, L., Hébert, S.S., Human Molecular Genetics, 2011, 10.1093/hmg/ddr330
MicroRNAs and Alzheimer's disease mouse models: Current insights and future research avenues, Hébert, S.S., Delay, C., International Journal of Alzheimer's Disease, 2011, 10.4061/2011/894938
Genetic ablation of dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration, Hébert, S.S., Papadopoulou, A.S., Smith, P., Galas, M.-C., Planel, E., Silahtaroglu, A.N., Sergeant, N., Buée, L., de Strooper, B., Human Molecular Genetics, 2010, 10.1093/hmg/ddq311
The miR-15/107 group of MicroRNA genes: Evolutionary biology, cellular functions, and roles in human diseases, Finnerty, J.R., Wang, W.-X., Hébert, S.S., Wilfred, B.R., Mao, G., Nelson, P.T., Journal of Molecular Biology, 2010, 10.1016/j.jmb.2010.07.051
Alterations of the microRNA network cause neurodegenerative disease, Hébert, S.S., De Strooper, B., Trends in Neurosciences, 2009, 10.1016/j.tins.2008.12.003
Alzheimer research forum live discussion: Non-coding RNAs in neurodegeneration, Albensi, B., Breen, G., Cashikar, A., Chai, X., Chang, R., Cuellar, T., Frederikse, P., Hayashi, M., Hebert, S., Kinoshita, J., Kosik, K., Long, J., Maloney, B., Mizumoto, L., Muresan, V., Neilson, J., Nelson, P., Perry, R., Smalheiser, N., Stanek, L., Townsend, M., Turner, L., Umansky, S., Wang, W.-X., Xu, G., Journal of Alzheimer's Disease, 2009, 10.3233/JAD-2009-1007
Epigenetic control of aquaporin 1 expression by the amyloid precursor protein, Huysseune, S., Kienlen-Campard, P., Hébert, S., Tasiaux, B., Leroy, K., Devuyst, O., Brion, J.-P., De Strooper, B., Octave, J.-N., FASEB Journal, 2009, 10.1096/fj.09-140012
MicroRNA regulation of Alzheimer's Amyloid precursor protein expression, Hébert, S.S., Horré, K., Nicolaï, L., Bergmans, B., Papadopoulou, A.S., Delacourte, A., De Strooper, B., Neurobiology of Disease, 2009, 10.1016/j.nbd.2008.11.009
Increased AICD generation does not result in increased nuclear translocation or activation of target gene transcription, Waldron, E., Isbert, S., Kern, A., Jaeger, S., Martin, A.M., Hébert, S.S., Behl, C., Weggen, S., De Strooper, B., Pietrzik, C.U., Experimental Cell Research, 2008, 10.1016/j.yexcr.2008.05.003
Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression, Hébert, S.S., Horré, K., Nicolaï, L., Papadopoulou, A.S., Mandemakers, W., Silahtaroglu, A.N., Kauppinen, S., Delacourte, A., De Strooper, B., Proceedings of the National Academy of Sciences of the United States of America, 2008, 10.1073/pnas.0710263105
Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis, O'Connor, T., Sadleir, K.R., Maus, E., Velliquette, R.A., Zhao, J., Cole, S.L., Eimer, W.A., Hitt, B., Bembinster, L.A., Lammich, S., Lichtenthaler, S.F., Hébert, S.S., De Strooper, B., Haass, C., Bennett, D.A., Vassar, R., Neuron, 2008, 10.1016/j.neuron.2008.10.047
Molecular biology: miRNAs in neurodegeneration, Hébert, S.S., De Strooper, B., Science, 2007, 10.1126/science.1148530
Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes, Hébert, S.S., Serneels, L., Tolia, A., Craessaerts, K., Derks, C., Filippov, M.A., Müller, U., De Strooper, B., EMBO Reports, 2006, 10.1038/sj.embor.7400704
Up-regulation of inositol 1,4,5-trisphosphate receptor type 1 is responsible for a decreased endoplasmic-reticulum Ca²⁺ content in presenilin double knock-out cells, Kasri, N.N., Kocks, S.L., Verbert, L., Hébert, S.S., Callewaert, G., Parys, J.B., Missiaen, L., De Smedt, H., Cell Calcium, 2006, 10.1016/j.ceca.2006.03.005
Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain, Leyssen, M., Ayaz, D., Hébert, S.S., Reeve, S., De Strooper, B., Hassan, B.A., EMBO Journal, 2005, 10.1038/sj.emboj.7600757
Differential contribution of the three Aph1 genes to γ-secretase activity in vivo, Serneels, L., Dejaegere, T., Craessaerts, K., Horré, K., Jorissen, E., Tousseyn, T., Hébert, S., Coolen, M., Martens, G., Zwijsen, A., Annaert, W., Hartmann, D., De Strooper, B., Proceedings of the National Academy of Sciences of the United States of America, 2005, 10.1073/pnas.0408901102
The amyloid-β precursor protein: Integrating structure with biological function, Reinhard, C., Hébert, S.S., De Strooper, B., EMBO Journal, 2005, 10.1038/sj.emboj.7600860
Coordinated and widespread expression of γ-secretase in vivo: Evidence for size and molecular heterogeneity, Hébert, S.S., Serneels, L., Dejaegere, T., Horré, K., Dabrowski, M., Baert, V., Annaert, W., Hartmann, D., De Strooper, B., Neurobiology of Disease, 2004, 10.1016/j.nbd.2004.08.002
Dimerization of presenilin-1 in vivo: Suggestion of novel regulatory mechanisms leading to higher order complexes, Hébert, S.S., Godin, C., Tomiyama, T., Mori, H., Lévesque, G., Biochemical and Biophysical Research Communications, 2003, 10.1016/S0006-291X(02)02984-4
Oligomerization of human presenilin-1 fragments, Hébert, S.S., Godin, C., Lévesque, G., FEBS Letters, 2003, 10.1016/S0014-5793(03)00813-5
Presenilin-1 interacts directly with the β-site amyloid protein precursor cleaving enzyme (BACE1), Hébert, S.S., Bourdages, V., Godin, C., Ferland, M., Carreau, M., Lévesque, G., Neurobiology of Disease, 2003, 10.1016/S0969-9961(03)00035-4
Presenilin-I is indirectly implicated in Notchl cleavage, Godin, C., Auclair, A., Ferland, M., Hébert, S.S., Carreau, M., Lévesque, G., NeuroReport, 2003, 10.1097/00001756-200308260-00014
The mixed lineage kinase DLK is oligomerized by tissue transglutaminase during apoptosis, Hebert, S.S., Daviau, A., Grondin, G., Latreille, M., Aubin, R.A., Blouin, R., Journal of Biological Chemistry, 2000

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Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009

Sidney Dupuis - Maitrîse avec mémoire - En cours
Marie-Josée Dupras - Maitrîse avec mémoire - En cours
Francis Jolivette - Maitrîse avec mémoire - En cours
Serena Petry - Post-doctorat - En cours
Behnaz Nateghi - Doctorat - En cours
Rémi Keraudren - Maitrîse avec mémoire - En cours
Malia Bouaziz - Doctorat - En cours
Pascal Smith - Maitrîse avec mémoire - 2014/05
Sepideh Parsi - Doctorat - 2016/05
Andréanne Turgeon - Maitrîse avec mémoire - 2018/05
Sara Rainone - Doctorat - 2018/09
Isabelle Guisle - Doctorat - 2020/01
Emmanuelle Boscher - Doctorat - 2020/01

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.

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