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Sébastien Bonnet
Professeur titulaire
Groupe de recherche en santé respiratoire
Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec
Centre de recherche de l'IUCPQ
Contribution à la recherche
Thématiques de recherche de la Faculté de médecine
- Santé cardiovasculaire, respiratoire et métabolisme
Projets de recherche en cours
- Targeting Integrin Signaling to Alleviate Remodeling in Pulmonary Arteries and the Right Ventricle in Pulmonary Hypertension - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2024-10-01 au 2029-09-30
- Exploring the Interplay between Metabolic and Epigenetic Signalling Pathways to Regulate Neointima Hyperplasia - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2023-10-01 au 2028-09-30
- Targeting Mitosis and Senescence to Reverse Pulmonary Hypertension: A Promising Therapeutic Strategy - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2023-10-01 au 2028-09-30
- Targeting Hypusine signaling: an opportunity to counter pulmonary vascular remodelling in pulmonary arterial hypertension - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2023-04-01 au 2028-03-31
- ATP Citrate Lyase: an attractive target at the nexus of metabolic and epigenetic alterations in pulmonary arterial hypertension - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2022-04-01 au 2027-03-31
- Endothelial-pericyte interactions in the pathogenesis of pulmonary arterial hypertension - National Institute of Health (USA) - Subvention de recherche, Stanford University, co-chercheur - 2023-07-01 au 2026-06-30
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Financements des 2 dernières années
- Étude de la physiopathologie de hypertension artérielle pulmonaire et d'insuffisance cardiaque droite - Subvention d’aide à la recherche - Fonds de recherche du Québec - Santé - Subvention d’aide à la recherche, chercheur principal - 2021-07-01 au 2025-06-30
- Étude de la physiopathologie de hypertension artérielle pulmonaire et d'insufisance cardiaque droite - Fonds de recherche du Québec - Santé - Chercheurs-boursiers de mérite, chercheur principal - 2021-07-01 au 2025-06-30
- The anti-oxidative DNA damage protein MTH1, the novel pulmonary hypertension Achilles heel - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2020-04-01 au 2025-03-31
- Role of the long non-coding RNA H19 as a novel biomarker and therapeutic target in right ventricular failure in pulmonary arterial hypertension - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2019-04-01 au 2024-03-31
- BRD4 Inhibition in Pulmonary Arterial Hypertension: a Phase 2 Clinical Trial - Resverlogix Corp, Instituts de recherche en santé du Canada - Subvention de fonctionnement : Application clinique de l’épigénétique, co-chercheur - 2019-02-01 au 2023-01-31
- PARP inhibition in PAH: A Phase 1 clinical trial - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2018-10-01 au 2021-09-30
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Publications
- Corrigendum to “A Simple Method to Assess In Vivo Proliferation in Lung Vasculature with EdU: The Case of MMC-Induced PVOD in Rat”, Frédéric Perros, Sébastien Bonnet, Edmund Lau, Valérie Nadeau, Benoît Ranchoux, Fabrice Antigny, Analytical Cellular Pathology, 2017, 10.1155/2017/4697379
- The Latest in Animal Models of Pulmonary Hypertension and Right Ventricular Failure, Sebastien Bonnet, Allan Lawrie, Vineet Agrawal, Olivier Boucherat, Circulation Research, 2022, 10.1161/CIRCRESAHA.121.319971
- Preclinical Investigation of Trifluoperazine as a Novel Therapeutic Agent for the Treatment of Pulmonary Arterial Hypertension, sebastien bonnet, Olivier Boucherat, Roxane Paulin, Steeve Provencher, Eve Tremblay, Sandra Breuils-Bonnet, Mark Orcholski, Kana Shimauchi, Valérie Nadeau, Victoria Toro, Alice Bourgeois, Charlotte Romanet, Sarah-Eve Lemay, Charifa Awada, Yann Grobs, International Journal of Molecular Sciences, 2021, 10.3390/ijms22062919
- Right Ventricle and Epigenetics: A Systematic Review, François Potus, Steeve Provencher, Sebastien Bonnet, Olivier Boucherat, Naomie Jutras-Beaudoin, Victoria Toro, Cells, 2023, 10.3390/cells12232693
- Proteomic Signatures of Right Ventricular Outcomes in Pulmonary Arterial Hypertension, Peter J. Leary, Sina A. Gharib, Ali Shojaie, Samuel G. Rayner, Laura Oppegard, Claudio A. Bravo, Sébastien Bonnet, Anna R. Hemnes, Karthik Suresh, Olivier Boucherat, Lu Xia, Hongyang Pi, Circulation: Heart Failure, 2024, 10.1161/CIRCHEARTFAILURE.124.012067
- Novel Insights into the Therapeutic Potential of Lung-Targeted Gene Transfer in the Most Common Respiratory Diseases, Lahouaria Hadri, Sébastien Bonnet, Irene C. Turnbull, Shahood Fazal, Xiao-Qing Sun, Malik Bisserier, Cells, 2022, 10.3390/cells11060984
- Prognostic Significance of Proteomics‐Discovered Circulating Inflammatory Biomarkers in Patients With Pulmonary Arterial Hypertension, Steeve Provencher, Sébastien Bonnet, François Potus, Jey Jeyaseelan, Shanker Kalyana‐Sundaram, Vinod Krishna, Sandra Breuils‐Bonnet, Sarah‐Eve Lemay, Sandra Martineau, Olivier Boucherat, Tetsuro Yokokawa, Journal of the American Heart Association, 2024, 10.1161/JAHA.123.032888
- Implication of EZH2 in the Pro-Proliferative and Apoptosis-Resistant Phenotype of Pulmonary Artery Smooth Muscle Cells in PAH: A Transcriptomic and Proteomic Approach, Olivier Boucherat, Roxane Paulin, sebastien bonnet, Steeve Provencher, François Potus, David Gutstein, Jey Jeyaseelan, Mark Orcholski, Florence Roux-Dalvai, Valérie Nadeau, Sandra Martineau, Ghada Mkannez, Eve Tremblay, Sandra Breuils-Bonnet, Vinod Krishna, Yann Grobs, Alice Bourgeois, Charifa Awada, Junichi Omura, Karima Habbout, International Journal of Molecular Sciences, 2021, 10.3390/ijms22062957
- Revisiting the Role for HIF Stabilizers in Bronchopulmonary Dysplasia, Sebastien Bonnet, Eric D. Austin, Olivier Boucherat, American Journal of Respiratory and Critical Care Medicine, 2020, 10.1164/rccm.202006-2570ED
- Time Is Running Out in Pulmonary Arterial Hypertension: The Epigenetic Clock Is Clicking, François Potus, Sébastien Bonnet, Steeve Provencher, Olivier Boucherat, Shanker Kalyana-Sundaram, Vinod Krishna, Sandra Martineau, Sandra Breuils-Bonnet, Nabil Azhar, Reem El Kabbout, American Journal of Respiratory Cell and Molecular Biology, 2024, 10.1165/rcmb.2023-0335LE
- Fetal Gene Reactivation in Pulmonary Arterial Hypertension: GOOD, BAD, or BOTH?, Olivier Boucherat, Steeve Provencher, sebastien bonnet, Wen-Hui Wu, Tsukasa Shimauchi, Charifa Awada, Sarah-Eve Lemay, Cells, 2021, 10.3390/cells10061473
- Unraveling the Impact of miR-146a in Pulmonary Arterial Hypertension Pathophysiology and Right Ventricular Function, Carmen Brás-Silva, Adelino F. Leite-Moreira, Fabrice Antigny, Frédéric Perros, David Montani, Sébastien Bonnet, Steeve Provencher, Bastien Masson, Anaïs Saint-Martin Willer, Manu Poels, Beatriz Rego, Carolina Maia-Rocha, Rui Adão, Pedro Mendes-Ferreira, Joana Santos-Gomes, International Journal of Molecular Sciences, 2024, 10.3390/ijms25158054
- Pulmonary tumor thrombotic microangiopathy: A systematic review of the literature, S. Provencher, S. Bonnet, R. Paulin, P. Joubert, D. Wiseman, L. V. Morin-Thibault, Canadian Journal of Respiratory, Critical Care, and Sleep Medicine, 2021, 10.1080/24745332.2020.1724061
- DNA–Protein Kinase Catalytic Subunit as a Potential Target for Pulmonary Arterial Hypertension, Sébastien Bonnet, Olivier Boucherat, Steeve Provencher, François Potus, Mabrouka Salem, Sandra Breuils-Bonnet, Tetsuro Yokokawa, Sarah-Eve Lemay, Keiko Yamamoto, American Journal of Respiratory Cell and Molecular Biology, 2023, 10.1165/rcmb.2022-0239LE
- Collagen Triple Helix Repeat-Containing Protein 1: More Than Just a Novel Biomarker for Right Ventricular Involvement in Pulmonary Hypertension, Sebastien Bonnet, Francois Potus, Canadian Journal of Cardiology, 2024, 10.1016/j.cjca.2024.06.021
- Assessment of Clinical Worsening End Points as a Surrogate for Mortality in Pulmonary Arterial Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Steeve Provencher, Jean-Christophe Lega, Sebastien Bonnet, Yves Lacasse, Jason Weatherald, Roubi Kilo, Annie C. Lajoie, Vicky Mai, Camille Gosselin, Élodie Tremblay, Circulation, 2022, 10.1161/CIRCULATIONAHA.121.058635
- Involvement of PFKFB3 in Pulmonary Arterial Hypertension Pathogenesis. Is It All about Glycolysis?, Roxane Paulin, Sebastien Bonnet, American Journal of Respiratory and Critical Care Medicine, 2019, 10.1164/rccm.201902-0394ED
- Mendelian Randomization in Pulmonary Arterial Hypertension: Unveiling Early Insights With Promise for Future Discoveries, Sebastien Bonnet, Benoit J. Arsenault, Steeve Provencher, Journal of the American Heart Association, 2024, 10.1161/JAHA.123.033446
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Contribution à l'enseignement aux cycles supérieurs
Étudiant(e)s dirigé(e)s*
Depuis 2020/07- Tsukasa Shimauchi - Post-doctorat - En cours
- Sarah-Eve Lemay - Doctorat - En cours
- Tetsuro Yokokawa - Post-doctorat - En cours
- Keiko Yamamoto - Post-doctorat - En cours
- Coralie Bilodeau - Maîtrise avec mémoire - En cours
- Alice Bourgeois - Doctorat - En cours
- Reem EL Kabbout - Doctorat - En cours
- Manon Mougin - Doctorat - En cours
- Karima Habbout - Doctorat - 2021/05
- Mélanie Sauvaget - Maîtrise avec mémoire - 2022/05
- Charifa Awada - Doctorat - 2022/09
- Géraldine Vitry - Doctorat - 2023/01
- Yann Grobs - Doctorat - 2024/05
- Victoria Toro - Doctorat - 2024/09
- Charlotte Romanet - Doctorat - 2025/01
Encadrement d'étudiant(e)s
Direction de recherche dans les domaines suivants :
- Médecine moléculaire
- Sciences cliniques et biomédicales
- Kinésiologie
En savoir plus sur les programmes
Disponibilité d'encadrement d'étudiant(e)s
Ce (cette) professeur(e) est présentement à la recherche d'étudiant(e)s.
Envoyer un courriel*Les supervisions d’étudiant(e)s de 1er cycle en
stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées
ultérieurement.