Découvrez nos professeurs et professeures!

Revenir au répertoire
Fiche précédente
Fiche suivante

Pierre Savard

Professeur titulaire

Pierre.Savard@fmed.ulaval.ca
Centre de recherche du CHU de Québec - Université Laval
Partager la fiche :

Contribution à la recherche

Thématiques de recherche de la Faculté de médecine

  • Neurosciences et santé mentale

Financements des 2 dernières années

  • Manufacturing of antigens and adjuvants for development of vaccines (MAAV) - Fondation Canadienne pour l'innovation (La), Ministère de la Santé et des Services sociaux, Fondation du CHU de Québec - Fonds d'innovation (FI), co-chercheur - 2020-11-01 au 2022-03-31

Publications

  • Peroxovanadium compounds as inhibitors of angiogenesis, Savard, P.E., Posner, B.I., Faure, R.L., Doillon, C.J., Angiogenesis, 1999, 10.1023/A:1026577418765
  • Retrovirus-induced murine motor neuron disease: mapping the determinant of spongiform degeneration within the envelope gene., Jolicoeur P, Robitaille Y, Brousseau R, Savard P, Hanna Z, Paquette Y, Proceedings of the National Academy of Sciences of the United States of America, 1989, 10.1073/pnas.86.10.3896
  • Efficacy of a Virus-Like Nanoparticle As Treatment for a Chronic Viral Infection Is Hindered by IRAK1 Regulation and Antibody Interference., Lamarre A, Leclerc D, Savard P, Tarrab E, Lebel MÈ, Chartrand K, Frontiers in immunology, 2017, 10.3389/fimmu.2017.01885
  • Expression of Hox A11 in the limb and the regeneration blastema of adult newt, Savard, P., Tremblay, M., Noiseux, N., Beauchemin, M., International Journal of Developmental Biology, 1994
  • Modulation of Antigen Display on PapMV Nanoparticles Influences Its Immunogenicity, Leclerc D, Savard P, Olivera-Ugarte S, Garneau C, Bolduc M, Laliberté-Gagné M, 2020, 10.20944/preprints202012.0327.v1
  • Influence of PapMV nanoparticles on the kinetics of the antibody response to flu vaccine., Leclerc D, Savard P, Gagné MÈ, Bolduc M, Russell A, Carignan D, Rioux G, Journal of nanobiotechnology, 2016, 10.1186/s12951-016-0200-2
  • Poly(Adenosine Diphosphoribose) Polymerase Activity and Adenosine Diphosphate Ribosylation of Proteins during Pancreatic Degeneration and Regeneration, Whish, W.J.D., Poirier, G.G., Lord, A., Aubin, R., Savard, P., Cancer Research, 1981
  • Poly(adenosine diphosphoribose) polymerase activity and adenosine diphosphate ribosylation of proteins during pancreatic degeneration and regeneration., Poirier GG, Lord A, Whish WJ, Aubin R, Savard P, Cancer research, 1981
  • Action of amitriptyline on histamine receptors in the rat brain,ACTION DE L'ADMINISTRATION SUR LES RECEPTEURS DE L'HISTAMINE DANS LE CERVEAU DE RAT, Bedard, P.S., Merand, Y., Savard, P., Union Medicale du Canada, 1981
  • A novel M2e based flu vaccine formulation for dogs., Savard P, López-Macias C, López-Macias C, Babin C, Rivest M, Leclerc D, PloS one, 2013, 10.1371/journal.pone.0077084
  • Determination of 5-hydroxytryptophan, 5-hydroxytryptamine, and 5-hydroxyindoleacetic acid in 20 rat brain nuclei using liquid chromatography with electrochemical detection, Daigle, M., Dupont, A., Savard, P., Di Paolo, T., Canadian Journal of Physiology and Pharmacology, 1983, 10.1139/y83-081
  • Increased Immunogenicity of Full-Length Protein Antigens through Sortase-Mediated Coupling on the PapMV Vaccine Platform., Leclerc D, Estaquier J, Savard P, Casault P, Garneau C, Thérien A, Bolduc M, Laliberté-Gagné MÈ, Vaccines, 2019, 10.3390/vaccines7020049
  • Potentiating Cancer Immunotherapy Using Papaya Mosaic Virus-Derived Nanoparticles., Lamarre A, Leclerc D, Savard P, Tarrab E, Chartrand K, Lebel MÈ, Nano letters, 2016, 10.1021/acs.nanolett.5b04877
  • Opiate peptides: distribution and relation to the neuroendocrine system,Peptides opiacés: distribution et relation avec le système neuroendocrinien., Dupont, A., Rouleau, D., Savard, P., Mérand, Y., Barden, N., Union Medicale du Canada, 1980
  • Differential regulation of Hox C6 in the appendages of adult urodeles and anurans, Tremblay, M., Savard, P., Journal of Molecular Biology, 1995, 10.1006/jmbi.1995.0345
  • Effect of neonatal hypothyroidism on the serotonin and somatostatin levels of the CNS,EFFET DE L'HYPOTHYROIDIE NEONATALE SUR LES NIVEAUX EN SEROTONINE ET SOMATOSTATINE DU SYSTEME NERVEUX CENTRAL (SNC), Dupont, A., DiPaolo, T., Savard, P., Merand, Y., Union Medicale du Canada, 1981
  • Nanoparticle adjuvant sensing by TLR7 enhances CD8+ T cell-mediated protection from Listeria monocytogenes infection., Lamarre A, Leclerc D, Labrecque N, Savard P, Kalinke U, Tarrab E, Chartrand K, Daudelin JF, Lebel MÈ, Journal of immunology (Baltimore, Md. : 1950), 2013, 10.4049/jimmunol.1302030
  • Engineering of the PapMV vaccine platform with a shortened M2e peptide leads to an effective one dose influenza vaccine., Leclerc D, Savard P, Bolduc M, Gagné ML, Paquet G, Rioux G, Thérien A, Carignan D, Vaccine, 2015, 10.1016/j.vaccine.2015.10.123
  • A Randomized Controlled Study to Evaluate the Safety and Reactogenicity of a Novel rVLP-Based Plant Virus Nanoparticle Adjuvant Combined with Seasonal Trivalent Influenza Vaccine Following Single Immunization in Healthy Adults 18-50 Years of Age., Savard P, McElhaney J, Lapointe R, Cailhier JF, Thibodeau V, Grange C, Ye L, MacKinnon-Cameron D, ElSherif M, McNeil S, Halperin S, Pastural E, Langley J, Vaccines, 2020, 10.3390/vaccines8030393
  • Activation of innate immunity in primary human cells using a plant virus derived nanoparticle TLR7/8 agonist., Leclerc D, Savard P, Duval M, Bolduc M, Laliberté-Gagné MÈ, Herblot S, Carignan D, Nanomedicine : nanotechnology, biology, and medicine, 2017, 10.1016/j.nano.2017.10.015
  • Effects of thyroid state on serotonin, 5-hydroxyindoleacetic acid and substance P contents in discrete brain nuclei of adult rats, Dupont, A., Di Paolo, T., Mérand, Y., Savard, P., Neuroscience, 1983, 10.1016/0306-4522(83)90121-5
  • [Opiate peptides: distribution and relation to the neuroendocrine system]., Rouleau D, Dupont A, Savard P, Mérand Y, Barden N, L'union medicale du Canada, 1980
  • Evidence that cholecystokinin is a neurotransmitter of olfaction in nucleus olfactorius anterior, Dockray, G.J., Leblanc, J., Savard, P., Dupont, A., Mérand, Y., Brain Research, 1982, 10.1016/0006-8993(82)90437-1
  • Age-related changes in central nervous system enkephalins and substance P, Boissier, J.R., Labrie, F., Mérand, Y., Savard, P., Dupont, A., Life Sciences, 1981, 10.1016/0024-3205(81)90565-8
  • 3H-mepyramine binding in various regions of rat brain following chronic treatment with different classes of antidepressant drugs, Dupont, A., Merand, Y., Savard, P., Progress in Neuropsychopharmacology and Biological Psychiatry, 1982, 10.1016/S0278-5846(82)80126-7
  • 2744. A Phase I Randomized, Observer-Blind, Controlled, Dose Escalation Trial of the Safety and Tolerability of a Single Intramuscular Dose of a PAL Adjuvant (Laboratory Code, FB-631) Co-administered with Seasonal TIV (2013–2014) to Healthy Adults ≥18–50 Years of Age, Savard P, Bolduc M, Martin L, McElhaney J, Lapointe R, Ye L, MacKinnon-Cameron D, ElSherif M, McNeil S, Halperin S, Halperin S, Pastural E, Langley J, Open forum infectious diseases, 2019
  • [Relation between neonatal hypothyroidism and the central nervous system]., Barden N, Savard P, Mérand Y, Gagné B, Coulombe P, Di Paolo T, Dussault JH, Dupont A, L'union medicale du Canada, 1981
  • Body axis determination during early development in amphibians., Savard, P., Biochemistry and cell biology = Biochimie et biologie cellulaire, 1992, 10.1139/o92-136
  • Two distal-less related homeobox-containing genes expressed in regeneration blastemas of the newt, Savard, P., Beauchemin, M., Developmental Biology, 1992, 10.1016/0012-1606(92)90047-K
  • Effect of neonatal hypothyroidism on the serotonin system of the rat brain, Dupont, A., Paolo, T.D., Mérand, Y., Savard, P., Brain Research, 1984, 10.1016/0006-8993(84)90894-1
  • Structure and dynamics of Mycobacterium tuberculosis truncated hemoglobin N: insights from NMR spectroscopy and molecular dynamics simulations., Gagné SM, Guertin M, Lagüe P, Meindre F, Sebilo A, Morin S, Daigle R, Savard PY, Biochemistry, 2011, 10.1021/bi201059a
  • Position dependent expression of a homeobox gene transcript in relation to amphibian limb regeneration., Brockes, J.P., Gates, P.B., Savard, P., The EMBO journal, 1988, 10.1002/j.1460-2075.1988.tb03325.x
  • Homeobox-containing genes in the newt are organized in clusters similar to other vertebrates, Savard, P., Noiseux, N., Tremblay, M., Bauchemin, M., Belleville, S., Gene, 1992, 10.1016/0378-1119(92)90572-7
  • Molecular evolution of type VI intermediate filament proteins, Vincent, M., Savard, P.E., Khan, P.A., Guérette, D., BMC Evolutionary Biology, 2007, 10.1186/1471-2148-7-164
  • Expression of five homeobox genes in the adult newt appendages and regeneration blastemas., Savard, P., Beauchemin, M., Progress in clinical and biological research, 1993
  • Poly(ADP-ribose) polymerase activity in mouse cells which exhibit temperature-sensitive DNA synthesis, Sheinin, R., Poirier, G.G., Savard, P., BBA Section Nucleic Acids And Protein Synthesis, 1981, 10.1016/0005-2787(81)90162-3
  • The effects of p-chlorophenylalanine (PCPA) treatment on the substance P content measured in discrete brain nuclei of normal and neonatally-induced hypothyroid rats, Dupont, A., Mérand, Y., Savard, P., Brain Research, 1984, 10.1016/0006-8993(84)90770-4
  • Limitation of access to highly palatable foods increases the norepinephrine content of many discrete hypothalamic and amygdaloidal nuclei of rat brain, Dupont, A., Leblanc, J., Mérand, Y., Savard, P., Life Sciences, 1983, 10.1016/0024-3205(83)90160-1
  • A versatile papaya mosaic virus (PapMV) vaccine platform based on sortase-mediated antigen coupling., Leclerc D, Savard P, Bolduc M, Laliberté-Gagné MÈ, Gauthier-Landry L, Rioux G, Carignan D, Bédard M, Thérien A, Journal of nanobiotechnology, 2017, 10.1186/s12951-017-0289-y
  • Expression of Hox A11 in the limb and the regeneration blastema of adult newt., Savard P, Tremblay M, Noiseux N, Beauchemin M, The International journal of developmental biology, 1994
  • The quest for a nanoparticle-based vaccine inducing broad protection to influenza viruses., Leclerc D, Savard P, Boivin G, Russel A, Garneau C, Carignan D, Laliberté-Gagné MÈ, Baz M, Bolduc M, Nanomedicine : nanotechnology, biology, and medicine, 2018, 10.1016/j.nano.2018.08.010
  • Protein tyrosine phosphatase inhibition induces anti-tumor activity: Evidence of Cdk2/p27kip1 and Cdk2/SHP-1 complex formation in human ovarian cancer cells, Faure, R.L., Lussier, J.G., Shink, E., Olivier, M., Doillon, C.J., Savard, P.E., Caron, D., Cancer Letters, 2008, 10.1016/j.canlet.2007.12.012
  • Graded expression of Emx-2 in the adult newt limb and its corresponding regeneration blastema, Savard, P., Tremblay, M., Tsonis, P.A., Del Rio-Tsonis, K., Beauchemin, M., Journal of Molecular Biology, 1998, 10.1006/jmbi.1998.1782
  • Molecular polymorphism of the intermediate filament protein transitin, Vincent, M., Cole, G.J., Savard, P.E., Juge, N., Davis, L., Darenfed, H., Ma, X., Histochemistry and Cell Biology, 2001, 10.1007/s00418-001-0333-7
  • Comparative effects of neonatal hypothyroidism and euthyroidism on TRH and substance P content of lumbar spinal cord in saline and PCPA-treated rats, Dupont, A., Dussault, J.H., Bédard, P., Mérand, Y., Savard, P., Brain Research, 1983, 10.1016/0006-8993(83)90933-2
  • The effects of chronic antihistaminic and antidepressant agents on histamine H1- and H2-receptors in rat brain, Bedard, P.S., Merand, Y., Savard, P., Neuroendocrinology Letters, 1981
  • Serotonin, 5-hydroxyindoleacetic acid and substance P content of discrete brain nuclei in rats made hypo- or hyperthyroid in the neonatal period: Effect of growth hormone treatment, Dupont, A., Mérand, Y., Blanchard, L.M., Savard, P., Developmental Brain Research, 1984, 10.1016/0165-3806(84)90101-9
  • ADP-ribosylation of pancreatic histone H1 and of other histones., Savard, P., Poirier, G.G., Canadian journal of biochemistry, 1980, 10.1139/o80-069
  • Important role of the long terminal repeat of the helper Moloney murine leukemia virus in Abelson virus-induced lymphoma., Jolicoeur P, Poirier Y, Rassart E, DesGroseillers L, Savard P, Journal of virology, 1987, 10.1128/jvi.61.10.3266-3275.1987
  • The developmentally regulated avian protein IFAPa-400 is transitin, Vincent, M., Savard, P.E., Cole, G.J., Charron, F., Ma, X., Developmental Brain Research, 1998, 10.1016/S0165-3806(98)00062-5
  • Modulation of Antigen Display on PapMV Nanoparticles Influences Its Immunogenicity., Leclerc D, Savard P, Olivera-Ugarte SM, Garneau C, Bolduc M, Laliberté-Gagné ME, Vaccines, 2021, 10.3390/vaccines9010033
  • Influences of both thyroid and bovine growth hormones on substance P, thyrotropin-releasing hormone, serotonin and 5-hydroxyindoleacetic acid contents in the lumbar spinal cord of developing rats, Dupont, A., Dussault, J.H., Bédard, P., Mérand, Y., Blanchard, L.M., Savard, P., Developmental Brain Research, 1984, 10.1016/0165-3806(84)90081-6
  • Properties of poly(ADP-ribose) synthetase from rat pancreas and poly(ADP- ribosylation) of basic nuclear proteins, Rajotte, D., Savard, P., Poirier, G.G., Canadian Journal of Biochemistry, 1978, 10.1139/o78-119
  • Complement Component 3 Regulates IFN-α Production by Plasmacytoid Dendritic Cells following TLR7 Activation by a Plant Virus-like Nanoparticle., Leclerc D, Lamarre A, Savard P, Tarrab E, Daudelin JF, Langlois MP, Lebel MÈ, Journal of immunology (Baltimore, Md. : 1950), 2016, 10.4049/jimmunol.1601271
  • Expression of five homeobox genes in the adult newt appendages and regeneration blastemas., Savard P, Beauchemin M, Progress in clinical and biological research, 1993
  • Antiangiogenic properties of a novel shark cartilage extract: Potential role in the treatment of psoriasis, Sauder, D.N., Pelletier, G., Maes, D.H., Ross, N., Marenus, K., Thibodeau, A., Juneau, C., Jourdain, C., Savard, P.E., Dupont, É., Journal of Cutaneous Medicine and Surgery, 1998, 10.1177/120347549800200307
  • PapMV nanoparticles improve mucosal immune responses to the trivalent inactivated flu vaccine., Leclerc D, Savard P, Laliberté-Gagné ME, Russell A, Bolduc M, Mathieu C, Rioux G, Journal of nanobiotechnology, 2014, 10.1186/1477-3155-12-19

Contribution à l'enseignement aux cycles supérieurs

Encadrement d'étudiant(e)s

Direction de recherche dans les domaines suivants :

  • Biologie cellulaire et moléculaire

En savoir plus sur les programmes

Disponibilité d'encadrement d'étudiant(e)s

Ce (cette) professeur(e) est présentement à la recherche d'étudiant(e)s.

Envoyer un courriel
Mettre à jour mon profil de professeur(e)