Patrick Rochette
Professeur titulaire
Centre de recherche en organogenèse expérimentale
Centre de recherche du CHU de Québec - Université Laval
Contribution à la recherche
Axe de recherche de l'Université Laval :
Santé et bien-être durables
Thématiques de recherche de la Faculté de médecine :
Médecine régénératrice et moléculaire
Neurosciences et santé mentale
Oncologie
Domaines et intérêts de recherche du (de la) professeur(e) :
Cancer
- Cancer de la peau
- Carcinogénèse
- Environnement et cancer
- Apoptose et cancer
Génétique humaine
- Génétique moléculaire
- Mutation (processus)
Neurosciences, santé mentale et toxicomanies
- Maladies de l'oeil et du système visuel
- Système visuel
Vieillissement
- Dégénérescence cellulaire
- Âge et facteurs de risques
Projets de recherche
- Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
- Toxicity of high-energy visible light for retinal pigment epithelial cells in cigarette smokers and polluted environments. - CHU de Québec – Université Laval – CHUL - Développement de la recherche (FC), chercheur principal - 2022-02-01 au 2025-01-31
- Fuchs endothelial corneal dystrophy and corneal transplantation: The traditional paradigm revisited - Instituts de recherche en santé du Canada - Subvention Projet, Université de Montréal, co-chercheur - 2019-10-01 au 2024-09-30
- Toxicité de la lumière et dysfonctionnement mitochondrial dans l’oeil humain - Fonds de recherche du Québec - Santé - Chercheur-boursier Juniors 1 et 2, Seniors, chercheur principal - 2021-07-01 au 2024-06-30
- Salaire d'un professeur sous octroi - CHU de Québec – Université Laval – CHUL, chercheur principal - 2009-06-01 au 2024-06-30
- Réponse cellulaire au stress génotoxique induit par l'irradiation chronique aux rayons ultraviolets. - Conseil de recherches en sciences naturelles et génie Canada, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2016-04-01 au 2022-03-31
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Publications
- The Influence of Blue-Filtering Intraocular Lenses Implant on Exudative Age-Related Macular Degeneration: A Case–Control Study, Thierry Hamel, Justine Rheault, David Simonyan, Serge Bourgault, Patrick J Rochette, Clinical Ophthalmology, 2021, 10.2147/OPTH.S300461
- The T414G mitochondrial DNA mutation: a biomarker of ageing in human eye, Anne-Sophie Gary, Marie M Dorr, Patrick J Rochette, Mutagenesis, 2021, 10.1093/mutage/geab003
- The use of tissue-engineered skin to demonstrate the negative effect of CXCL5 on epidermal UV radiation-induced CPD repair efficiency. , , The British journal of dermatology, 2020, 10.1111/bjd.19117
- Apple extract (Malus sp.) and rutin as photochemopreventive agents: Evaluation of UVB-induced alterations on skin biopsies and tissue-engineered skin. , , Rejuvenation research, 2020, 10.1089/rej.2019.2219
- Chronology of cellular events related to mitochondrial burnout leading to cell death in Fuchs endothelial corneal dystrophy. , , Scientific reports, 2020, 10.1038/s41598-020-62602-x
- Potential of sub-microsecond laser pulse shaping for controlling microcavitation in selective retinal therapies., , Biomedical optics express, 2019, 10.1364/boe.11.000109
- Impact of ultraviolet radiation on dermal and epidermal DNA damage in a human pigmented bilayered skin substitute., , Journal of tissue engineering and regenerative medicine, 2019, 10.1002/term.2959
- Chronic UVA1 Irradiation of Human Dermal Fibroblasts: Persistence of DNA Damage and Validation of a Cell Cultured-Based Model of Photoaging., , The Journal of investigative dermatology, 2019, 10.1016/j.jid.2019.02.022
- Absorption of blue light by cigarette smoke components is highly toxic for retinal pigmented epithelial cells., , Archives of toxicology, 2018, 10.1007/s00204-018-2344-3
- Function-Related Protein Expression in Fuchs Endothelial Corneal Dystrophy Cells and Tissue Models., , The American journal of pathology, 2018, 10.1016/j.ajpath.2018.03.014
- Enhancement of UVB-induced DNA damage repair after a chronic low-dose UVB pre-stimulation., , DNA repair, 2018, 10.1016/j.dnarep.2018.01.008
- Short wavelengths filtering properties of sunglasses on the Canadian market: are we protected?, , Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 2017, 10.1016/j.jcjo.2017.09.006
- Extracellular Matrix and Integrin Expression Profiles in Fuchs Endothelial Corneal Dystrophy Cells and Tissue Model., , Tissue engineering. Part A, 2017, 10.1089/ten.tea.2017.0128
- Persistence and Tolerance of DNA Damage Induced by Chronic UVB Irradiation of the Human Genome., , The Journal of investigative dermatology, 2017, 10.1016/j.jid.2017.08.044
- Ultraviolet A-induced oxidation in cornea: Characterization of the early oxidation-related events., , Free radical biology & medicine, 2017, 10.1016/j.freeradbiomed.2017.03.022
- Influence of a pre-stimulation with chronic low-dose UVB on stress response mechanisms in human skin fibroblasts., , PloS one, 2017, 10.1371/journal.pone.0173740
- Restoration of Mitochondrial Integrity, Telomere Length, and Sensitivity to Oxidation by In Vitro Culture of Fuchs' Endothelial Corneal Dystrophy Cells., , Investigative ophthalmology & visual science, 2016, 10.1167/iovs.16-20551
- Telomere Length Measurement in Different Ocular Structures: A Potential Implication in Corneal Endothelium Pathogenesis., , Investigative ophthalmology & visual science, 2016, 10.1167/iovs.16-19878
- Faster DNA Repair of Ultraviolet-Induced Cyclobutane Pyrimidine Dimers and Lower Sensitivity to Apoptosis in Human Corneal Epithelial Cells than in Epidermal Keratinocytes., , PloS one, 2016, 10.1371/journal.pone.0162212
- Association of Telomere Length with Breast Cancer Prognostic Factors., , PloS one, 2016, 10.1371/journal.pone.0161903
- Modifications in stromal extracellular matrix of aged corneas can be induced by ultraviolet A irradiation., , Aging cell, 2015, 10.1111/acel.12324
- Contribution of Sp1 to Telomerase Expression and Activity in Skin Keratinocytes Cultured With a Feeder Layer., , Journal of cellular physiology, 2015, 10.1002/jcp.24706
- Implication of ultraviolet light in the etiology of uveal melanoma: A review., , Photochemistry and photobiology, 2013, 10.1111/php.12161
- Wavelength-dependent ultraviolet induction of cyclobutane pyrimidine dimers in the human cornea., , Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2013, 10.1039/c3pp25408a
- The 3895-bp mitochondrial DNA deletion in the human eye: a potential involvement in corneal ageing and macular degeneration., , Mutagenesis, 2013, 10.1093/mutage/ges071
- Rescue of the transcription factors Sp1 and NFI in human skin keratinocytes through a feeder-layer-dependent suppression of the proteasome activity., , Journal of molecular biology, 2012, 10.1016/j.jmb.2012.01.021
- Mitochondrial DNA common deletion in the human eye: a relation with corneal aging., , Mechanisms of ageing and development, 2012, 10.1016/j.mad.2012.01.002
- Ultraviolet light-induced cyclobutane pyrimidine dimers in rabbit eyes., , Photochemistry and photobiology, 2011, 10.1111/j.1751-1097.2011.00977.x
- Human telomeres are hypersensitive to UV-induced DNA Damage and refractory to repair., , PLoS genetics, 2010, 10.1371/journal.pgen.1000926
- [Mapping DNA damage to understand somatic mutagenesis]., , Medecine sciences : M/S, 2010, 10.1051/medsci/2010262193
- MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication., , The EMBO journal, 2009, 10.1038/emboj.2009.235
- Influence of cytosine methylation on ultraviolet-induced cyclobutane pyrimidine dimer formation in genomic DNA., , Mutation research, 2009, 10.1016/j.mrfmmm.2009.02.008
- Progressive apoptosis resistance prior to senescence and control by the anti-apoptotic protein BCL-xL., , Mechanisms of ageing and development, 2008, 10.1016/j.mad.2007.12.007
- Bcl-2 is the target of a UV-inducible apoptosis switch and a node for UV signaling., , Proceedings of the National Academy of Sciences of the United States of America, 2007, 10.1073/pnas.0701318104
- Pyrimidine (6-4) pyrimidone photoproduct mapping after sublethal UVC doses: nucleotide resolution using terminal transferase-dependent PCR., , Photochemistry and photobiology, 2006, 10.1562/2004-12-01-ra-390
- SW480, a p53 double-mutant cell line retains proficiency for some p53 functions., , Journal of molecular biology, 2005, 10.1016/j.jmb.2005.06.033
- UVA-induced cyclobutane pyrimidine dimers form predominantly at thymine-thymine dipyrimidines and correlate with the mutation spectrum in rodent cells., , Nucleic acids research, 2003, 10.1093/nar/gkg402
- Human cells bearing homozygous mutations in the DNA mismatch repair genes hMLH1 or hMSH2 are fully proficient in transcription-coupled nucleotide excision repair., , Oncogene, 2002, 10.1038/sj.onc.1205641
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Contribution à l'enseignement aux cycles supérieurs
Étudiant(e)s dirigé(e)s*
Depuis 2009- Alexe Grenier - Doctorat - En cours
- Nataly Trang - Maitrîse avec mémoire - En cours
- Sophie Amouret - Doctorat - En cours
- Eloïse Larnac - Doctorat - En cours
- Marie-Christine Lambert - Doctorat - En cours
- Sébastien Méthot - Doctorat - En cours
- Mylène Bélanger-Poulin - Maitrîse avec mémoire - En cours
- Sébastien Gendron - Maitrîse avec mémoire - 2014/01
- Justin Mallet - Doctorat - 2016/01
- Pascal Deladurantaye - Maitrîse avec mémoire - 2016/09
- Marie Catherine Drigeard Desgarnier - Doctorat - 2017/09
- Roxanne Bérubé - Maitrîse avec mémoire - 2017/09
- Marie Dorr - Doctorat - 2019/05
- Anne-Sophie Gary - Doctorat - 2021/05
- Corinne Zinflou - Doctorat - 2021/09
Encadrement d'étudiant(e)s pour les programmes suivants :
Disponibilité d'encadrement d'étudiant(e)s
Ce (cette) professeur(e) est présentement à la recherche d'étudiant(e)s.
Envoyer un courriel*Les supervisions d’étudiant(e)s de 1er cycle en
stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées
ultérieurement.