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Patrick Rochette

Professeur titulaire

Patrick Rochette
Centre de recherche en organogenèse expérimentale
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Médecine régénératrice et moléculaire
Neurosciences et santé mentale
Oncologie

Domaines et intérêts de recherche du (de la) professeur(e) :

Cancer
  • Cancer de la peau
  • Carcinogénèse
  • Environnement et cancer
  • Apoptose et cancer
Génétique humaine
  • Génétique moléculaire
  • Mutation (processus)
Neurosciences, santé mentale et toxicomanies
  • Maladies de l'oeil et du système visuel
  • Système visuel
Vieillissement
  • Dégénérescence cellulaire
  • Âge et facteurs de risques

Projets de recherche

  • Toxicité des rayons ultraviolets sous l’angle de la mitochondrie - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2023-04-01 au 2028-03-31
  • Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
  • Toxicity of high-energy visible light for retinal pigment epithelial cells in cigarette smokers and polluted environments. - CHU de Québec – Université Laval – CHUL - Développement de la recherche (FC), chercheur principal - 2022-02-01 au 2025-01-31
  • Fuchs endothelial corneal dystrophy and corneal transplantation: The traditional paradigm revisited - Instituts de recherche en santé du Canada - Subvention Projet, Université de Montréal, co-chercheur - 2019-10-01 au 2024-09-30
  • Toxicité de la lumière et dysfonctionnement mitochondrial dans l’oeil humain - Fonds de recherche du Québec - Santé - Chercheur-boursier Juniors 1 et 2, Seniors, chercheur principal - 2021-07-01 au 2024-06-30
  • Salaire d'un professeur sous octroi - CHU de Québec – Université Laval – CHUL, chercheur principal - 2009-06-01 au 2024-06-30
  • Réponse cellulaire au stress génotoxique induit par l'irradiation chronique aux rayons ultraviolets. - Conseil de recherches en sciences naturelles et génie Canada, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2016-04-01 au 2022-03-31
  • Journée annuelle de la recherche en ophtalmologie - Allergan inc., Bausch Health, Canada Inc., chercheur principal - 2019-04-23 au 2021-03-31

Publications

  • Pyrimidine (6-4) pyrimidone photoproduct mapping after sublethal UVC doses: nucleotide resolution using terminal transferase-dependent PCR., , Photochemistry and photobiology, 2006, 10.1562/2004-12-01-ra-390
  • UVA-induced cyclobutane pyrimidine dimers form predominantly at thymine-thymine dipyrimidines and correlate with the mutation spectrum in rodent cells., , Nucleic acids research, 2003, 10.1093/nar/gkg402
  • Influence of cytosine methylation on ultraviolet-induced cyclobutane pyrimidine dimer formation in genomic DNA., , Mutation research, 2009, 10.1016/j.mrfmmm.2009.02.008
  • Progressive apoptosis resistance prior to senescence and control by the anti-apoptotic protein BCL-xL., , Mechanisms of ageing and development, 2008, 10.1016/j.mad.2007.12.007
  • Implication of ultraviolet light in the etiology of uveal melanoma: A review., , Photochemistry and photobiology, 2013, 10.1111/php.12161
  • The 3895-bp mitochondrial DNA deletion in the human eye: a potential involvement in corneal ageing and macular degeneration., , Mutagenesis, 2013, 10.1093/mutage/ges071
  • MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication., , The EMBO journal, 2009, 10.1038/emboj.2009.235
  • Association of Telomere Length with Breast Cancer Prognostic Factors., , PloS one, 2016, 10.1371/journal.pone.0161903
  • Contribution of Sp1 to Telomerase Expression and Activity in Skin Keratinocytes Cultured With a Feeder Layer., , Journal of cellular physiology, 2015, 10.1002/jcp.24706
  • Ultraviolet A-induced oxidation in cornea: Characterization of the early oxidation-related events., , Free radical biology & medicine, 2017, 10.1016/j.freeradbiomed.2017.03.022
  • Persistence and Tolerance of DNA Damage Induced by Chronic UVB Irradiation of the Human Genome., , The Journal of investigative dermatology, 2017, 10.1016/j.jid.2017.08.044
  • Enhancement of UVB-induced DNA damage repair after a chronic low-dose UVB pre-stimulation., , DNA repair, 2018, 10.1016/j.dnarep.2018.01.008
  • Function-Related Protein Expression in Fuchs Endothelial Corneal Dystrophy Cells and Tissue Models., , The American journal of pathology, 2018, 10.1016/j.ajpath.2018.03.014
  • Modifications in stromal extracellular matrix of aged corneas can be induced by ultraviolet A irradiation., , Aging cell, 2015, 10.1111/acel.12324
  • Mitochondrial DNA common deletion in the human eye: a relation with corneal aging., , Mechanisms of ageing and development, 2012, 10.1016/j.mad.2012.01.002
  • Ultraviolet light-induced cyclobutane pyrimidine dimers in rabbit eyes., , Photochemistry and photobiology, 2011, 10.1111/j.1751-1097.2011.00977.x
  • Human telomeres are hypersensitive to UV-induced DNA Damage and refractory to repair., , PLoS genetics, 2010, 10.1371/journal.pgen.1000926
  • Bcl-2 is the target of a UV-inducible apoptosis switch and a node for UV signaling., , Proceedings of the National Academy of Sciences of the United States of America, 2007, 10.1073/pnas.0701318104
  • Restoration of Mitochondrial Integrity, Telomere Length, and Sensitivity to Oxidation by In Vitro Culture of Fuchs' Endothelial Corneal Dystrophy Cells., , Investigative ophthalmology & visual science, 2016, 10.1167/iovs.16-20551
  • Telomere Length Measurement in Different Ocular Structures: A Potential Implication in Corneal Endothelium Pathogenesis., , Investigative ophthalmology & visual science, 2016, 10.1167/iovs.16-19878
  • Absorption of blue light by cigarette smoke components is highly toxic for retinal pigmented epithelial cells., , Archives of toxicology, 2018, 10.1007/s00204-018-2344-3
  • Impact of ultraviolet radiation on dermal and epidermal DNA damage in a human pigmented bilayered skin substitute., , Journal of tissue engineering and regenerative medicine, 2019, 10.1002/term.2959
  • Reduction of DNA damage repair efficiency and accumulation of residual damage following chronic UVB-irradiation of HaCaT cells, Patrick J. Rochette, Marie M. Dorr, PLOS ONE, 2023, 10.1371/journal.pone.0283572
  • Lipid Peroxidation as the Mechanism Underlying Polycyclic Aromatic Hydrocarbons and Sunlight Synergistic Toxicity in Dermal Fibroblasts, Patrick J. Rochette, Laurent Marrot, Valérie Haydont, Alicia Montoni, Eloïse Larnac, International Journal of Molecular Sciences, 2024, 10.3390/ijms25031905
  • Human cells bearing homozygous mutations in the DNA mismatch repair genes hMLH1 or hMSH2 are fully proficient in transcription-coupled nucleotide excision repair., , Oncogene, 2002, 10.1038/sj.onc.1205641
  • The T414G mitochondrial DNA mutation: a biomarker of ageing in human eye, Patrick J Rochette, Marie M Dorr, Anne-Sophie Gary, Mutagenesis, 2021, 10.1093/mutage/geab003
  • The use of tissue-engineered skin to demonstrate the negative effect of CXCL5 on epidermal UV radiation-induced CPD repair efficiency. , , The British journal of dermatology, 2020, 10.1111/bjd.19117
  • Short wavelengths filtering properties of sunglasses on the Canadian market: are we protected?, , Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 2017, 10.1016/j.jcjo.2017.09.006
  • Indenopyrene and Blue-Light Co-Exposure Impairs the Tightly Controlled Activation of Xenobiotic Metabolism in Retinal Pigment Epithelial Cells: A Mechanism for Synergistic Toxicity, Patrick J. Rochette, Corinne Zinflou, International Journal of Molecular Sciences, 2023, 10.3390/ijms242417385
  • The Influence of Blue-Filtering Intraocular Lenses Implant on Exudative Age-Related Macular Degeneration: A Case–Control Study, Patrick J Rochette, Serge Bourgault, David Simonyan, Justine Rheault, Thierry Hamel, Clinical Ophthalmology, 2021, 10.2147/OPTH.S300461
  • Apple extract (Malus sp.) and rutin as photochemopreventive agents: Evaluation of UVB-induced alterations on skin biopsies and tissue-engineered skin. , , Rejuvenation research, 2020, 10.1089/rej.2019.2219
  • Chronology of cellular events related to mitochondrial burnout leading to cell death in Fuchs endothelial corneal dystrophy. , , Scientific reports, 2020, 10.1038/s41598-020-62602-x
  • [Mapping DNA damage to understand somatic mutagenesis]., , Medecine sciences : M/S, 2010, 10.1051/medsci/2010262193
  • SW480, a p53 double-mutant cell line retains proficiency for some p53 functions., , Journal of molecular biology, 2005, 10.1016/j.jmb.2005.06.033
  • Rescue of the transcription factors Sp1 and NFI in human skin keratinocytes through a feeder-layer-dependent suppression of the proteasome activity., , Journal of molecular biology, 2012, 10.1016/j.jmb.2012.01.021
  • Wavelength-dependent ultraviolet induction of cyclobutane pyrimidine dimers in the human cornea., , Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2013, 10.1039/c3pp25408a
  • Influence of a pre-stimulation with chronic low-dose UVB on stress response mechanisms in human skin fibroblasts., , PloS one, 2017, 10.1371/journal.pone.0173740
  • Faster DNA Repair of Ultraviolet-Induced Cyclobutane Pyrimidine Dimers and Lower Sensitivity to Apoptosis in Human Corneal Epithelial Cells than in Epidermal Keratinocytes., , PloS one, 2016, 10.1371/journal.pone.0162212
  • Chronic UVA1 Irradiation of Human Dermal Fibroblasts: Persistence of DNA Damage and Validation of a Cell Cultured-Based Model of Photoaging., , The Journal of investigative dermatology, 2019, 10.1016/j.jid.2019.02.022
  • Extracellular Matrix and Integrin Expression Profiles in Fuchs Endothelial Corneal Dystrophy Cells and Tissue Model., , Tissue engineering. Part A, 2017, 10.1089/ten.tea.2017.0128
  • Potential of sub-microsecond laser pulse shaping for controlling microcavitation in selective retinal therapies., , Biomedical optics express, 2019, 10.1364/boe.11.000109

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Eloïse Larnac - Doctorat - En cours
  • Sophie Amouret - Doctorat - En cours
  • Johanna aime agathe yaba Niamke - Maîtrise avec mémoire - En cours
  • Sébastien Gendron - Maîtrise avec mémoire - 2014/01
  • Justin Mallet - Doctorat - 2016/01
  • Pascal Deladurantaye - Maîtrise avec mémoire - 2016/09
  • Marie Catherine Drigeard Desgarnier - Doctorat - 2017/09
  • Roxanne Bérubé - Maîtrise avec mémoire - 2017/09
  • Marie-Christine Lambert - Maîtrise avec mémoire - 2019/01
  • Marie Dorr - Doctorat - 2019/05
  • Sébastien Méthot - Maîtrise avec mémoire - 2020/01
  • Anne-Sophie Gary - Doctorat - 2021/05
  • Corinne Zinflou - Doctorat - 2021/09
  • Alexe Grenier - Doctorat - 2022/09

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.