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Patrick Provost

Professeur titulaire

Patrick Provost
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Médecine régénératrice et moléculaire

Domaines et intérêts de recherche du (de la) professeur(e) :

Génétique humaine
  • Expression et régulation génique
  • Génomique
  • Protéomique
  • Protéines
  • Micropuces d'ADN et d'ARN
  • Maladies génétiques
Nutrition et métabolisme
  • Nutrition
  • Processus de digestion
  • Appareil digestif
  • Pathologies de l'appareil digestif
  • Maladie de Crohn
  • Produits nutraceutiques et aliments fonctionnels
Cellulaire
  • Gène
  • Cellule
Génomique et protéomique

Projets de recherche

  • Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
  • A unique model to assess the oral transfer of dietary microRNAs - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2019-10-01 au 2024-09-30
  • A novel class of small non-coding RNAs - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC), Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2019-04-01 au 2024-03-31

Publications

  • Platelet microparticles reprogram macrophage gene expression and function, , Thromb Haemost, 2015, 10.1160/th15-05-0389
  • Differential Expression Analysis by RNA-Seq Reveals Perturbations in the Platelet mRNA Transcriptome Triggered by Pathogen Reduction Systems, , PLoS One, 2015, 10.1371/journal.pone.0133070
  • Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA, , Proc Natl Acad Sci U S A, 2015, 10.1073/pnas.1507905112
  • Dicer cleavage by calpain determines platelet microRNA levels and function in diabetes, , Circ Res, 2015, 10.1161/circresaha.117.305784
  • Dissociation of SERPINE1 mRNA from the translational repressor proteins Ago2 and TIA-1 upon platelet activation, , Thromb Haemost, 2015, 10.1160/th14-07-0622
  • A mutation interfering with 5-lipoxygenase domain interaction leads to increased enzyme activity, Rakonjac Ryge, M., Tanabe, M., Provost, P., Persson, B., Chen, X., Funk, C. D., Rinaldo-Matthis, A., Hofmann, B., Steinhilber, D., Watanabe, T., Samuelsson, B., Rådmark, O., Arch Biochem Biophys, 2014, 10.1016/j.abb.2014.01.017
  • Effects of pathogen reduction systems on platelet microRNAs, mRNAs, activation, and function, Osman, A., Hitzler, W. E., Meyer, C. U., Landry, P., Corduan, A., Laffont, B., Boilard, E., Hellstern, P., Vamvakas, E. C., Provost, P., Platelets, 2014, 10.3109/09537104.2014.898178
  • Activated platelets can deliver mRNA regulatory Ago2bulletmicroRNA complexes to endothelial cells via microparticles., Laffont, Benoit, Corduan, Aurelie, Ple, Helene, Duchez, Anne-Claire, Cloutier, Nathalie, Boilard, Eric, Provost, Patrick, Blood, 2013, 10.1182/blood-2013-03-492801
  • Regulation of host gene expression by HIV-1 TAR microRNAs, Ouellet, D. L., Vigneault-Edwards, J., Létourneau, K., Gobeil, L. A., Plante, I., Burnett, J. C., Rossi, J. J., Provost, P., Retrovirology, 2013, 10.1186/1742-4690-10-86
  • Alteration of the platelet transcriptome in chronic kidney disease, Corduan, A., Madore, F., Maltais, M., Plé, H., Provost, P., Rousseau, G., Thromb Haemost, 2012, 10.1160/TH12-03-0153
  • DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88, Albuquerque, R. J., Ambati, B. K., Ambati, J., Baffi, J. Z., Bogdanovich, S., Chaudhuri, G., Chiodo, V. A., Cho, W. G., Dridi, S., Dunaief, J. L., Fowler, B. J., Gelfand, B. D., Goodrich, J. A., Hauswirth, W. W., Hinton, D. R., Hirano, Y., Kaneko, H., Kerur, N., Kim, Y., Kleinman, M. E., Kugel, J. F., Lee, D. K., Murphy, M. P., Núñez, G., Ogura, Y., Ponicsan, S. L., Provost, P., Tarallo, V., Yoo, J. W., Cell, 2012, 10.1016/j.cell.2012.03.036
  • Modulation of microRNA Activity by Semi-microRNAs, Gunaratne, P. H., Landry, P., Plante, I., Plé, H., Provost, P., Front Genet, 2012, 10.3389/fgene.2012.00099
  • Regulation of human Dicer by the resident ER membrane protein CLIMP-63, Perron, M. P., Provost, P., Pépin, G., Nucleic Acids Res, 2012, 10.1093/nar/gks903
  • The Repertoire and Features of Human Platelet microRNAs, Benham, A., Coarfa, C., Gunaratne, P. H., Landry, P., Plé, H., Provost, P., PLoS One, 2012, 10.1371/journal.pone.0050746
  • Detection of human Dicer and Argonaute 2 catalytic activity, Landry, P., Perron, M. P., Plante, I., Provost, P., Methods Mol Biol, 2011, 10.1007/978-1-61779-046-1_9
  • Dicer-mediated upregulation of BCRP confers tamoxifen resistance in human breast cancer cells, Albain, K., Ando, S., Barone, I., Beyer, A., Boumendjel, A., Covington, K. R., Di Pietro, A., Dontu, G., Fuqua, S. A., Gu, G., Herynk, M. H., Lewis, M. T., Miele, L., Provost, P., Selever, J., Tsimelzon, A., Weiss, H., Clin Cancer Res, 2011, 10.1158/1078-0432.CCR-11-1403
  • DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration, Albuquerque, R. J., Ambati, B. K., Ambati, J., Baffi, J. Z., Blandford, A. D., Bogdanovich, S., Braun, R. E., Buaas, F. W., Chaudhuri, G., Chiodo, V. A., Cho, W. G., Chong, M. M., Dridi, S., Dunaief, J. L., Fowler, B. J., Fuchs, E., Gelfand, B. D., Goodrich, J. A., Grossniklaus, H. E., Hadziahmetovic, M., Hauswirth, W. W., Hinton, D. R., Hirano, Y., Justice, N. L., Kaneko, H., Karikó, K., Kleinman, M. E., Kugel, J. F., Lee, D. K., Littman, D. R., Madigan, M. C., Milam, A. H., Misra, S., Ponicsan, S. L., Provis, J. M., Provost, P., Rudin, C. M., Song, Y., Tarallo, V., Witta, J., Yoo, J. W., Zhang, Q., Nature, 2011, 10.1038/nature09830
  • Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102, Esser, J, Fischer, L, Hofmann, B, Provost, P, Radmark, O, Rakonjac, M, Samuelsson, B, Schneider, G, Steinhilber, D, Biochemical Journal, 2010, 10.1042/BJ20090856
  • Current knowledge of MicroRNAs and noncoding RNAs in virus-infected cells, Ouellet, D. L., Provost, P., Methods Mol Biol, 2010, 10.1007/978-1-60761-588-0_3
  • Interpretation and applicability of microRNA data to the context of Alzheimer's and age-related diseases, Provost, P, Aging-Us, 2010
  • MicroRNAs as a molecular basis for mental retardation, Alzheimer's and prion diseases, Provost, P, Brain Research, 2010, 10.1016/j.brainres.2010.03.069
  • Existence of a microRNA pathway in anucleate platelets, Landry, P, Ouellet, DL, Perron, MP, Plante, I, Provost, P, Rousseau, G, Nature Structural & Molecular Biology, 2009, 10.1038/nsmb.1651
  • Human Dicer C-terminus functions as a 5-lipoxygenase binding domain, Dincbas-Renqvist, V, Doucet, J, Goulet, I, Hermansson, A, Ouellet, DL, Pepin, G, Plante, I, Provost, P, Radmark, O, Rakonjac, M, Samuelsson, B, Biochimica Et Biophysica Acta-Gene Regulatory Mechanisms, 2009, 10.1016/j.bbagrm.2008.10.002
  • MicroRNA-298 and MicroRNA-328 Regulate Expression of Mouse beta-Amyloid Precursor Protein-converting Enzyme 1, Boissonneault, V, Plante, I, Provost, P, Rivest, S, Journal of Biological Chemistry, 2009, 10.1074/jbc.M807530200
  • A polymerase chain reaction-based cloning strategy applicable to functional microRNA studies, Boissonneault, V, Plante, I, Provost, P, St-Gelais, N, Analytical Biochemistry, 2008, 10.1016/j.ab.2008.06.026
  • Identification of functional microRNAs released through asymmetrical processing of HIV-1 TAR element, Barat, C, Flamand, L, Janelle, ME, Landry, P, Ouellet, DL, Plante, I, Provost, P, Tremblay, MJ, Nucleic Acids Research, 2008, 10.1093/nar/gkn076
  • Involvement of Dcr1 in post-transcriptional regulation of gene expression in Schizosaccharomyces pombe, Gobeil, LA, Ouellette, M, Plante, P, Provost, P, Rohani, M, Frontiers in Bioscience, 2008, 10.2741/2835
  • Protein interactions and complexes in human microRNA biogenesis and function, Perron, MP, Provost, P, Frontiers in Bioscience, 2008, 10.2741/2865
  • Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A(4) production, Fischer, L, Provost, P, Radmark, O, Rakonjac, M, Samuelsson, B, Steinhilbert, D, Werz, O, Proceedings of the National Academy of Sciences of the United States of America, 2006, 10.1073/pnas.0605150103
  • Dicer-derived MicroRNAs are utilized by the fragile X mental retardation protein for assembly on target RNAs, Davidovic, L, Gobeil, LA, Khandjian, EW, Ouellet, DL, Plante, I, Provost, P, Tremblay, S, Journal of Biomedicine and Biotechnology, 2006, 10.1155/JBB/2006/64347
  • HIV-1 and the microRNA-guided silencing pathway: An intricate and multifaceted encounter, Barat, C, Plante, I, Provost, P, Tremblay, MJ, Virus Research, 2006, 10.1016/j.virusres.2006.06.015
  • Hypothesis: A role for fragile X mental retardation protein in mediating and relieving microRNA-guided translational repression?, Plante, I, Provost, P, Journal of Biomedicine and Biotechnology, 2006, 10.1155/JBB/2006/16806
  • MicroRNAs in gene regulation: When the smallest governs it all, Gobeil, LA, Ouellet, DL, Perron, MP, Plante, P, Provost, P, Journal of Biomedicine and Biotechnology, 2006, 10.1155/JBB/2006/69616
  • Ago1 and Dcr1, two core components of the RNA interference pathway, functionally diverge from Rdp1 in regulating cell cycle events in Schizosaccharomyces pombe, Carmichael, JB, Ekwall, K, Hobman, TC, Provost, P, Molecular Biology of the Cell, 2004, 10.1091/mbc.E03-06-0433
  • Letter to the Editor: NMR structure of human coactosin-like protein, Boissonneault, B, Liepinsh, E, Otting, G, Provost, P, Radmark, O, Rakonjac, M, Samuelsson, B, Journal of Biomolecular Nmr, 2004
  • Resistance of human hepatitis delta virus RNAs to dicer activity, Chang, JH, Provost, P, Taylor, JM, Journal of Virology, 2003, 10.1128/JVI.77.22.11910-11917.2003
  • The nuclear RNase III Drosha initiates microRNA processing, Ahn, C, Choi, H, Han, JJ, Kim, J, Kim, S, Kim, VN, Lee, J, Lee, Y, Provost, P, Radmark, O, Yim, J, Nature, 2003, 10.1038/nature01957
  • Dicer is required for chromosome segregation and gene silencing in fission yeast cells, Dishart, D, Djupedal, I, Ekwall, K, Kniola, B, Provost, P, Radmark, O, Samuelsson, B, Silverstein, RA, Walfridsson, J, Wright, A, Proceedings of the National Academy of Sciences of the United States of America, 2002, 10.1073/pnas.212633199
  • Molecular cloning and functional characterization of mouse coactosin-like protein, Doucet, J, Provost, P, Radmark, O, Samuelsson, B, Biochemical and Biophysical Research Communications, 2002, 10.1006/bbrc.2001.6236
  • Ribonuclease activity and RNA binding of recombinant human Dicer, Dishart, D, Doucet, J, Frendewey, D, Provost, P, Radmark, O, Samuelsson, B, Embo Journal, 2002
  • 5-Lipoxygenase interacts with coactosin-like protein, Doucet, J, Gerisch, G, Hammarberg, T, Provost, P, Radmark, O, Samuelsson, B, Journal of Biological Chemistry, 2001
  • Calcium binding site of 5-lipoxygenase, Folco, GC, Granstrom, E, Hammarberg, T, Nicosia, S, Paoletti, R, Persson, B, Provost, P, Radmark, O, Reddy, KV, Samuelsson, B, Advances in Prostaglandin and Leukotriene Research: Basic Science and New Clinical Applications, 2001
  • Coactosin-like protein, a human F-actin-binding protein: critical role lysine-75, Doucet, J, Gerisch, G, Provost, P, Radmark, O, Samuelsson, B, Stock, A, Biochemical Journal, 2001
  • The N-terminal domain of 5-lipoxygenase binds calcium and mediates calcium stimulation of enzyme activity, Hammarberg, T, Persson, B, Provost, P, Radmark, O, Journal of Biological Chemistry, 2000
  • Interaction of 5-lipoxygenase with cellular proteins, Provost, P, Radmark, O, Samuelsson, B, Proceedings of the National Academy of Sciences of the United States of America, 1999
  • Selectin blockade reduces neutrophil interaction with platelets at the site of deep arterial injury by angioplasty in pigs, Chauvet, P, Latour, JG, Merhi, Y, Phillips, ML, Provost, P, Theoret, JF, Arteriosclerosis Thrombosis and Vascular Biology, 1999
  • Platelets, neutrophils, and vasoconstriction after arterial injury by angioplasty in pigs: effects of MK-886, a leukotriene biosynthesis inhibitor, Borgeat, P, Merhi, Y, Provost, P, British Journal of Pharmacology, 1998
  • Endogenous nitric oxide release modulates mural platelet thrombosis and neutrophil-endothelium interactions under low and high shear conditions, Merhi, Y, Provost, P, Thrombosis Research, 1997
  • Endothelium-derived nitric oxide decreases polymorphonuclear leukocyte interaction with the deeply injured arterial wall under intermediate and high shear conditions, Merhi, Y, Provost, P, Thrombosis and Haemostasis, 1997
  • Importance of platelets in neutrophil adhesion and vasoconstriction after deep carotid arterial injury by angioplasty in pigs, Guidoin, R, Latour, JG, Merhi, Y, Provost, P, Arteriosclerosis Thrombosis and Vascular Biology, 1997
  • The antiadhesive and antithrombotic effects of the nitric oxide donor SIN-1 are combined with a decreased vasoconstriction in a porcine model of balloon angioplasty, Merhi, Y, Provost, P, Tremblay, J, Arteriosclerosis Thrombosis and Vascular Biology, 1997
  • BW755C, a dual lipoxygenase cyclooxygenase inhibitor, reduces mural platelet and neutrophil deposition and vasoconstriction after angioplasty injury in pigs, Merhi, Y, Provost, P, Journal of Pharmacology and Experimental Therapeutics, 1996
  • INCREASE OF NEUTROPHIL ADHESION AND VASOCONSTRICTION WITH PLATELET DEPOSITION AFTER DEEP ARTERIAL INJURY BY ANGIOPLASTY, GUIDOIN, R, LAM, JYT, LEUNG, TK, MERHI, Y, PROVOST, P, American Heart Journal, 1995
  • CLENTIAZEM GIVEN AT REPERFUSION IMPROVES SUBENDOCARDIAL REFLOW AND REDUCES MYOCARDIAL INFARCT SIZE IN THE DOG, CAILLE, G, LATOUR, JG, PROVOST, P, ROUSSEAU, G, TRAN, D, Journal of Pharmacology and Experimental Therapeutics, 1994
  • ENDOTHELIUM-DERIVED NITRIC-OXIDE ATTENUATES NEUTROPHIL ADHESION TO ENDOTHELIUM UNDER ARTERIAL FLOW CONDITIONS, LACOSTE, L, LAM, JYT, MERHI, Y, PROVOST, P, WATERS, D, Arteriosclerosis and Thrombosis, 1994
  • SUSTAINED MYOCARDIAL PROTECTION BY CLENTIAZEM (TA-3090) AFTER A 90-MINUTE CORONARY-OCCLUSION AND 72 HOURS OF REPERFUSION IN DOGS WITH COLLATERAL FLOW, LATOUR, JG, PROVOST, P, ROUSSEAU, G, Journal of Cardiovascular Pharmacology, 1993
  • MicroRNAs as Modulators of the Platelet Proteome, , 1911, http://dx.doi.org/10.2174/157016411797247468
  • Protein Components of the microRNA Pathway and Human Diseases, , 1911, http://dx.doi.org/10.1007/978-1-60327-547-7_18

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Raphaël Matusiak - Doctorat - En cours
  • Jean Denoyel - Doctorat - En cours
  • Jonathan Laugier - Doctorat - En cours
  • Idrissa Diallo - Doctorat - En cours
  • Sara Guellal - Doctorat - En cours
  • Geneviève Pépin - Doctorat - 2015/01
  • Aurélie Corduan - Doctorat - 2015/05
  • Benoit Laffont - Doctorat - 2015/05
  • Marine Lambert - Doctorat - 2021/01

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.

Direction et personnes-ressources

Vice-décanat à la recherche et aux études supérieures
Pavillon Ferdinand-Vandry
Université Laval
1050, avenue de la Médecine,  local 4645
Québec, Québec G1V 0A6
Canada

Renseignements - Secrétariat :
vdres@fmed.ulaval.ca
Téléphone 418 656-2690

Jacques Simard
Vice-doyen à la recherche et aux études supérieures
vice-doyen.recherche-et-etudes-superieures@fmed.ulaval.ca

Louise Laperrière
Adjointe au vice-doyen à la recherche et aux études supérieures
louise.laperriere@fmed.ulaval.ca 

Volet recherche
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Volet études aux cycles supérieurs