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Patrick Couture

Médecin clinicien enseignant titulaire

patrick.couture@fmed.ulaval.ca

Département de médecine

Centre de recherche en sciences et technologie du lait

Centre de recherche du CHU de Québec - Université Laval

Nutrition, santé et société (NUTRISS)

Institut sur la nutrition et les aliments fonctionnels

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Contribution à la recherche

Thématiques de recherche de la Faculté de médecine

Santé cardiovasculaire, respiratoire et métabolisme

Domaines de recherche

Nutrition clinique
Sciences cliniques sur le diabète
Métabolomique
Transcriptomique

Projets de recherche en cours

Institut sur la nutrition et les aliments fonctionnels (INAF) - Université Concordia, Institut national de recherche scientifique (INRS), Université du Québec à Rimouski, Fonds de recherche du Québec - Nature et technologies, Université McGill, Université Laval - Fonds internes, Merinov - Centre d'innovation de l'aquaculture et des pêches du Québec - Regroupements stratégiques NT, co-chercheur - 2024-04-01 au 2030-03-31
A 2x2 factorial randomized controlled trial to elucidate how ultra-processed foods modulate cardiometabolic risk - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2024-04-01 au 2028-03-31
Role of altered production of branched-chain hydroxy acids (BCHA) in the pathogenesis of type 2 diabetes (T2D) and fatty liver disease and its prevention by BCHA-supplemented yogurt - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2023-04-01 au 2028-03-31
Efficacité d'une intervention basée sur le coaching parental et l'analyse de la perception sensorielle des aliments chez les enfants autiste - Fondation de l'Université Laval, co-chercheur - 2024-12-18 au 2027-12-17
Unravelling the impact of diet on cardiovascular health in heterozygous familial hypercholesterolemia: a metabolomic approach - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2021-10-01 au 2025-09-30

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Financements des 2 dernières années

L’équilibre occupationnel est-il un facteur à prendre en considération dans les habitudes de vie des personnes à risque de maladie cardiovasculaire? : une étude exploratoire - Fonds de recherche du Québec - Santé - Projet subsidiaire - Nouveaux Centres et Instituts de recherche - Subventions régulières (pour fins de gestion au VRRCI), co-chercheur - 2024-04-05 au 2025-03-31
Dissecting host-microbiome modifiers of type 2 diabetes risk - Objective 1.1 - Instituts de recherche en santé du Canada - Subvention d'équipe : Initiative canadienne microbiome 2 : Équipes de recherche, co-chercheur - 2019-11-01 au 2024-10-31
Dissecting host-microbiome modifiers of type 2 diabetes risk - Objective 1.3 - Instituts de recherche en santé du Canada - Subvention d'équipe : Initiative canadienne microbiome 2 : Équipes de recherche, co-chercheur - 2019-11-01 au 2024-10-31
L'empreinte métabolomique plasmatique des produits laitiers: un reflet de leur consommation et une fenêtre sur leurs effets cardiométaboliques - Les producteurs laitiers du Canada - Subvention à la recherche en nutrition, co-chercheur - 2022-10-01 au 2024-09-30
Institut sur la nutrition et les aliments fonctionnels (INAF) - Institut national de recherche scientifique (INRS), Fonds de recherche du Québec - Nature et technologies, Université Laval - Fonds internes, Université McGill, Université du Québec à Rimouski, Université de Sherbrooke - Regroupements stratégiques NT, co-chercheur - 2017-04-01 au 2024-03-31
Mediterranean diet and physical activity: is the whole better than the sum of each part ? Clinical and mechanistic perspectives - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2018-04-01 au 2024-03-31
Validation de la mesure d’expression génique unicellulaire à partir d’un échantillon de tissu hépatique chez des sujets avec une suspicion clinique de stéatose hépatique non-alcoolique. - Fonds de recherche du Québec - Santé, chercheur principal - 2022-08-24 au 2023-08-23

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Publications

Common variants in cholesterol synthesis- and transport-related genes associate with circulating cholesterol responses to intakes of conventional dairy products in healthy individuals, Jones, P.J.H., Lamarche, B., Couture, P., Eck, P.K., Lépine, M.-C., Cyr, A., Abdullah, M.M.H., Journal of Nutrition, 2016, 10.3945/jn.115.222208
Characterization of a novel mutation causing hepatic lipase deficiency among French Canadians, Lamarche, B., Hegele, R.A., Simard, J., Deshaies, Y., Gagné, C., Couture, P., Ruel, I.L., Journal of Lipid Research, 2003, 10.1194/jlr.M200479-JLR200
High-oleic canola oil consumption enriches LDL particle cholesteryl oleate content and reduces LDL proteoglycan binding in humans, Rudel, L.L., Hantgan, R.R., Fleming, J.A., Liu, X., West, S.G., Kris-Etherton, P.M., Couture, P., Lamarche, B., Connelly, P.W., Jenkins, D.J.A., Pu, S., Senanayake, V.K., MacKay, D.S., Jones, P.J.H., Atherosclerosis, 2015, 10.1016/j.atherosclerosis.2014.12.010
Polymorphisms, de novo lipogenesis, and plasma triglyceride response following fish oil supplementation, Vohl, M.-C., Couture, P., Lemieux, S., Rudkowska, I., Bouchard-Mercier, A., Journal of Lipid Research, 2013, 10.1194/jlr.M041590
Polymorphisms in genes involved in fatty acid β-oxidation interact with dietary fat intakes to modulate the plasma TG response to a fish oil supplementation, Vohl, M.-C., Couture, P., Lemieux, S., Rudkowska, I., Bouchard-Mercier, A., Nutrients, 2014, 10.3390/nu6031145
Gene-diet interactions with polymorphisms of the MGLL gene on plasma low-density lipoprotein cholesterol and size following an omega-3 polyunsaturated fatty acid supplementation: A clinical trial, Vohl, M.-C., Couture, P., Lamarche, B., Lemieux, S., Rudkowska, I., Ouellette, C., Lipids in Health and Disease, 2014, 10.1186/1476-511X-13-86
Effects of ezetimibe and simvastatin on apolipoprotein B metabolism in males with mixed hyperlipidemia, Couture, P., Hogue, J.-C., Lamarche, B., Tremblay, A.J., Journal of Lipid Research, 2009, 10.1194/jlr.P800061-JLR200
Evidence of a founder effect for the protein C gene 3363 inserted C mutation in thrombophilic pedigrees of French origin, Long, G.L., Aiach, M., Rosendaal, F.R., Jomphe, M., Callas, P.W., Valliere, J.E., Scott, B.T., Delage, R., Simard, J., Demers, C., Bovill, E.G., Couture, P., Thrombosis and Haemostasis, 2001
Chronic venous abnormalities in symptomatic and asymptomatic protein C deficiency, Bovill, E.G., Rosendaal, F.R., Couture, P., Long, G.L., Naud, S., Demers, C., Callas, P.W., Vossen, C.Y., Emmerich, J., Journal of Thrombosis and Haemostasis, 2005, 10.1111/j.1538-7836.2005.01452.x
Genotype of the mutant LDL receptor allele is associated with LDL particle size heterogeneity in familial hypercholesterolemia, Couture, P., Gagné, C., Després, J.-P., Tremblay, A.J., Gaudet, D., Lamarche, B., Hogue, J.-C., Atherosclerosis, 2006, 10.1016/j.atherosclerosis.2005.03.027
The contribution of PCSK9 levels to the phenotypic severity of familial hypercholesterolemia is independent of LDL receptor genotype, Couture, P., Lamarche, B., Ooi, T.C., Hogue, J.-C., Tremblay, A.J., Drouin-Chartier, J.-P., Metabolism: Clinical and Experimental, 2015, 10.1016/j.metabol.2015.08.007
Effect of the APOC3 Sst I SNP on fasting triglyceride levels in men heterozygous for the LPL P207L deficiency, Bergeron, J., Julien, P., Couture, P., Gagné, C., Cadelis, F., Laflamme, N., Couillard, C., Garenc, C., European Journal of Human Genetics, 2005, 10.1038/sj.ejhg.5201469
Effect of an oat bran-rich supplement on the metabolic profile of overweight premenopausal women, Vohl, M.-C., Tchernof, A., Couture, P., Fontaine-Bisson, B., Robitaille, J., Annals of Nutrition and Metabolism, 2005, 10.1159/000086149
Expression of sar1b enhances chylomicron assembly and key components of the coat protein complex II system driving vesicle budding, Sane, A.T., Marcil, V., Couture, P., Delvin, E., Ziv, E., Sinnett, D., Emonnot, L., Sanchez, R., Laville, M., Harmel, E., Levy, E., Arteriosclerosis, Thrombosis, and Vascular Biology, 2011, 10.1161/ATVBAHA.111.233908
Hypertriglyceridemia and cardiovascular risk: a cautionary note about metabolic confounding, Thanassoulis, G., Wilkins, J.T., Cromwell, W.C., Lawler, P.R., Martin, S.S., DeGraaf, J., Couture, P., Sniderman, A.D., Journal of Lipid Research, 2018, 10.1194/jlr.R082271
Novel Genetic Loci Associated with the Plasma Triglyceride Response to an Omega-3 Fatty Acid Supplementation, Vohl, M.-C., Couture, P., Lemieux, S., Rudkowska, I., Guénard, F., Cormier, H., Vallée Marcotte, B., Journal of Nutrigenetics and Nutrigenomics, 2016, 10.1159/000446024
Comparison of the impact of SFAs from cheese and butter on cardiometabolic risk factors: A randomized controlled trial, Lamarche, B., Couture, P., Jones, P.J.H., Tremblay, A., Levy, E., Talbot, D., Gigleux, I., Ramprasath, V., She, Y., Rajendiran, E., Allaire, J., Tessier-Grenier, M., Brassard, D., American Journal of Clinical Nutrition, 2017, 10.3945/ajcn.116.150300
Lack of evidence for reduced plasma apo B48 catabolism in patients with heterozygous familial hypercholesterolemia carrying the same null LDL receptor gene mutation, Couture, P., Gagné, C., Bergeron, J., Hogue, J.-C., Ruel, I., Lamarche, B., Tremblay, A.J., Atherosclerosis, 2004, 10.1016/j.atherosclerosis.2003.11.011
Abdominal obesity, insulin resistance, metabolic syndrome and cholesterol homeostasis, Lamarche, B., Couture, P., Richard, C., Taverne, F., PharmaNutrition, 2013, 10.1016/j.phanu.2013.07.003
Inflammatory gene expression in whole blood cells after EPA vs. DHA supplementation: Results from the ComparED study, Lamarche, B., Couture, P., Tchernof, A., Charest, A., Lépine, M.-C., Marin, J., Allaire, J., Vors, C., Atherosclerosis, 2017, 10.1016/j.atherosclerosis.2017.01.025
Lipid Metabolism and Emerging Targets for Lipid-Lowering Therapy, Couture, P., Drouin-Chartier, J.-P., Gaudet, D., Canadian Journal of Cardiology, 2017, 10.1016/j.cjca.2016.12.019
A diagnostic algorithm for the atherogenic apolipoprotein B dyslipoproteinemias, Sniderman, A., Couture, P., De Graaf, J., Nature Clinical Practice Endocrinology and Metabolism, 2008, 10.1038/ncpendmet0982
Validation of the Friedewald formula for the determination of low-density lipoprotein cholesterol compared with β-quantification in a large population, Couture, P., Gagné, C., Bergeron, J., Gagné, J.-M., Morrissette, H., Tremblay, A.J., Clinical Biochemistry, 2004, 10.1016/j.clinbiochem.2004.03.008
Effect of ezetimibe on the in vivo kinetics of apoB-48 and apoB-100 in men with primary hypercholesterolemia, Couture, P., Hogue, J.-C., Cohn, J.S., Lamarche, B., Tremblay, A.J., Arteriosclerosis, Thrombosis, and Vascular Biology, 2006, 10.1161/01.ATV.0000216750.09611.ec
The elevation of plasma concentrations of apoB-48-containing lipoproteins in familial hypercholesterolemia is independent of PCSK9 levels, Couture, P., Lamarche, B., Bergeron, J., Tremblay, A.J., Hogue, J.-C., Drouin-Chartier, J.-P., Lipids in Health and Disease, 2017, 10.1186/s12944-017-0502-x
Association of specific LDL receptor gene mutations with differential plasma lipoprotein response to simvastatin in young French Canadians with heterozygous familial hypercholesterolemia, Gagné, C., Lupien, P.J., Simard, J., Després, J.-P., Gaudet, D., Szots, F., Lelièvre, M., Brun, L.D., Couture, P., Arteriosclerosis, Thrombosis, and Vascular Biology, 1998, 10.1161/01.ATV.18.6.1007
PPARα L162V polymorphism alters the potential of n-3 fatty acids to increase lipoprotein lipase activity, Vohl, M.-C., Barbier, O., Deshaies, Y., Couture, P., Verreault, M., Caron-Dorval, D., Rudkowska, I., Molecular Nutrition and Food Research, 2010, 10.1002/mnfr.200900085
Effect of the Mediterranean diet with and without weight loss on surrogate markers of cholesterol homeostasis in men with the metabolic syndrome, Lamarche, B., Lichtenstein, A.H., Seidah, N.G., Benjannet, S., Desroches, S., Couture, P., Richard, C., British Journal of Nutrition, 2012, 10.1017/S0007114511003436
A novel mutation of apolipoprotein B in a French Canadian family with homozygous hypobetalipoproteinemia, Gagné, C., Hegele, R.A., Martins, R., Couture, P., Bergeron, J., Gangloff, A., Journal of Clinical Lipidology, 2011, 10.1016/j.jacl.2011.06.014
Visceral adipose tissue accumulation, secretory phospholipase A 2-IIA and atherogenecity of LDL, Lamarche, B., Bergeron, N., Couture, P., Couillard, C., Mauger, J.-F., Hogue, M.-O., Paradis, M.-E., International Journal of Obesity, 2006, 10.1038/sj.ijo.0803315
ApoB in clinical care, Sniderman, A.D., Couture, P., De Graaf, J., ApoB in Clinical Care, 2015, 10.1007/978-90-368-0980-1
Impact of dairy products on biomarkers of inflammation: A systematic review of randomized controlled nutritional intervention studies in overweight and obese adults, Lamarche, B., Desroches, S., Richard, C., Couture, P., Labonté, M.-E., American Journal of Clinical Nutrition, 2013, 10.3945/ajcn.112.052217
Hypertensive Response to Exercise in Normotensive Men and Women with Abdominal Obesity: Association with Subclinical Adverse Cardiac Remodeling, Marie-Eve Piché, Benoit Lamarche, Paul Poirier, Jean-Pierre Després, Patrick Couture, Robert Ross, Myriam Pettigrew, Audrey Auclair, Mickael Martin, Maggie Lê-Brassard, Anne-Sophie Neyron, Iris Gigleux, Chloé Prémont, Marie-Anne Mathieu, Amelie Paquin, Journal of Clinical Medicine, 2024, 10.3390/jcm14010016
Development and validation of a Brief Diet Quality Assessment Tool in the French-speaking adults from Quebec, Lamarche, B., Lemieux, S., Couture, P., Talbot, D., Brisson, C., Laurin, D., Harrison, S., Lafrenière, J., International Journal of Behavioral Nutrition and Physical Activity, 2019, 10.1186/s12966-019-0821-6
Is lower and lower better and better? A re-evaluation of the evidence from the Cholesterol Treatment Trialists' Collaboration meta-analysis for low-density lipoprotein lowering, Furberg, C.D., Alam, A., Williams, K., Couture, P., Thanassoulis, G., Sniderman, A., Journal of Clinical Lipidology, 2012, 10.1016/j.jacl.2012.05.004
Assessing the impact of the diet on cardiometabolic outcomes: are multiple measurements post-intervention necessary?, Lamarche, B., Jenkins, D.J.A., Connelly, P.W., West, S.G., Kris-Etherton, P., Jones, P.J.H., Tchernof, A., Couture, P., Talbot, D., Allaire, J., European Journal of Clinical Nutrition, 2018, 10.1038/s41430-018-0257-0
Polymorphisms in genes involved in the triglyceride synthesis pathway and marine omega-3 polyunsaturated fatty acid supplementation modulate plasma triglyceride levels, Vohl, M.-C., Couture, P., Lemieux, S., Guénard, F., Rudkowska, I., Cormier, H., Ouellette, C., Journal of Nutrigenetics and Nutrigenomics, 2013, 10.1159/000357432
High-dose DHA has more profound effects on LDL-related features than high-dose EPA: The ComparED study, Lamarche, B., Couture, P., Tchernof, A., Charest, A., Marin, J., Tremblay, A.J., Vors, C., Allaire, J., Journal of Clinical Endocrinology and Metabolism, 2018, 10.1210/jc.2017-02745
Influence of LDL receptor gene mutation and apo E polymorphism on lipoprotein response to simvastatin treatment among adolescents with heterozygous familial hypercholesterolemia, Couture, P., Gagné, C., Bergeron, J., Lupien, P., Lelièvre, M., Szots, F., Vohl, M.-C., Atherosclerosis, 2002, 10.1016/S0021-9150(01)00584-6
A randomised crossover placebo-controlled trial investigating the effect of brown seaweed (Ascophyllum nodosum and fucus vesiculosus) on postchallenge plasma glucose and insulin levels in men and women, Lamarche, B., Couture, P., Paradis, M.-E., Applied Physiology, Nutrition and Metabolism, 2011, 10.1139/H11-115
Association of the A-204C polymorphism in the cholesterol 7α- hydroxylase gene with variations in plasma low density lipoprotein cholesterol levels in the Framingham Offspring Study, Ordovas, J.M., Schaefer, E.J., Wilson, P.W.F., Cupples, L.A., Otvos, J.D., Couture, P., Journal of Lipid Research, 1999
Absence of association between genetic variation in the promoter of the microsomal triglyceride transfer protein gene and plasma lipoproteins in the Framingham Offspring Study, Ordovas, J.M., Schaefer, E.J., Wilson, P.W.F., Cupples, L.A., Otvos, J.D., Couture, P., Atherosclerosis, 2000, 10.1016/S0021-9150(99)00281-6
Fine mapping of genome-wide association study signals to identify genetic markers of the plasma triglyceride response to an omega-3 fatty acid supplementation, Vohl, M.-C., Minihane, A.M., Calder, P.C., Rudkowska, I., Couture, P., Lemieux, S., Guénard, F., Marcotte, B.V., American Journal of Clinical Nutrition, 2019, 10.1093/ajcn/nqy298
Dha-enriched high-oleic acid canola oil improves lipid profile and lowers predicted cardiovascular disease risk in the canola oil multicenter randomized controlled trial, Kris-Etherton, P.M., McCrea, C.E., Fleming, J.A., Liu, X., West, S.G., Baril-Gravel, L., Charest, A., Couture, P., Lamarche, B., Connelly, P.W., Jenkins, D.J.A., Pu, S., Senanayake, V.K., Jones, P.J.H., American Journal of Clinical Nutrition, 2014, 10.3945/ajcn.113.081133
High serum triglyceride concentrations in patients with homozygous familial hypercholesterolemia attenuate the efficacy of lipoprotein apheresis by dextran sulfate adsorption, Couture, P., Lamarche, B., Bergeron, J., Tremblay, A.J., Drouin-Chartier, J.-P., Atherosclerosis, 2018, 10.1016/j.atherosclerosis.2018.01.005
Circulating levels of oxidative stress markers and endothelial adhesion molecules in men with abdominal obesity, Bergeron, N., Lamarche, B., Couture, P., Bergeron, J., Pomerleau, S., Archer, W.R., Ruel, G., Couillard, C., Journal of Clinical Endocrinology and Metabolism, 2005, 10.1210/jc.2004-2438
Lack of effect of dietary conjugated linoleic acids naturally incorporated into butter on the lipid profile and body composition of overweight and obese men, Bergeron, N., Couture, P., Lamarche, B., Delisle, J., Corneau, L., Galibois, I., Chouinard, P.Y., Desroches, S., American Journal of Clinical Nutrition, 2005
Identification of three mutations in the lowdensity lipoprotein receptor gene causing familial hypercholesterolemia among french canadians, Moorjani, S., Simard, J., Labrie, F., Després, J.P., Lupien, P.J., Torres, A.L., Gaudet, D., Gagné, C., Vohl, M.C., Couture, P., Human Mutation, 1998, 10.1002/humu.1380110173
Supplementation with high-dose docosahexaenoic acid increases the Omega-3 Index more than high-dose eicosapentaenoic acid, Lamarche, B., Couture, P., Tchernof, A., Jackson, K.H., Marin, J., Charest, A., Vors, C., Harris, W.S., Allaire, J., Prostaglandins Leukotrienes and Essential Fatty Acids, 2017, 10.1016/j.plefa.2017.03.008
The peroxisome proliferator-activated receptor α Leu162Val polymorphism influences the metabolic response to a dietary intervention altering fatty acid proportions in healthy men, Vohl, M.-C., Couture, P., Tchernof, A., Lamarche, B., Jacques, H., Lemieux, S., Robitaille, J., Bossé, Y., Fontaine-Bisson, B., Paradis, A.-M., American Journal of Clinical Nutrition, 2005
Cardiometabolic risk factors are influenced by Stearoyl-CoA Desaturase (SCD) -1 gene polymorphisms and n-3 polyunsaturated fatty acid supplementation, Vohl, M.-C., Barbier, O., Tchernof, A., Lemieux, S., Couture, P., Julien, P., Rudkowska, I., Molecular Nutrition and Food Research, 2014, 10.1002/mnfr.201300426
Expression of the androgen metabolizing enzyme UGT2B15 in adipose tissue and relative expression measurement using a competitive RT-PCR method, Bélanger, A., Hum, D.W., Després, J.-P., Couture, P., Beaulieu, M., Lévesque, E., Tchernof, A., Clinical Endocrinology, 1999, 10.1046/j.1365-2265.1999.00709.x
Differences in metabolomic and transcriptomic profiles between responders and non-responders to an n-3 polyunsaturated fatty acids (PUFAs) supplementation, Vohl, M.-C., Lemieux, S., Couture, P., Barbier, O., Julien, P., Thifault, E., Paradis, A.-M., Rudkowska, I., Genes and Nutrition, 2013, 10.1007/s12263-012-0328-0
Variations in HDL-carried miR-223 and miR-135a concentrations after consumption of dietary trans fat are associated with changes in blood lipid and inflammatory markers in healthy men - an exploratory study, Bouchard, L., Lamarche, B., Couture, P., Corbin, F., Guérin, R., Guay, S.-P., Desgagné, V., Epigenetics, 2016, 10.1080/15592294.2016.1176816
Molecular screening of the microsomal triglyceride transfer protein: Association between polymorphisms and both abdominal obesity and plasma apolipoprotein B concentration, Vohl, M.-C., Després, J.-P., Gaudet, D., Couture, P., Paradis, A.-M., Houde, A., Berthier, M.-T., Journal of Human Genetics, 2004, 10.1007/s10038-004-0207-7
The spectrum of type III hyperlipoproteinemia, Couture, P., Martin, S.S., Tremblay, A.J., Thanassoulis, G., de Graaf, J., Sniderman, A.D., Journal of Clinical Lipidology, 2018, 10.1016/j.jacl.2018.09.006
Transcriptomic and metabolomic signatures of an n-3 polyunsaturated fatty acids supplementation in a normolipidemic/normocholesterolemic Caucasian population, Vohl, M.-C., Barbier, O., Lemieux, S., Couture, P., Tchernof, A., Julien, P., Thifault, E., Paradis, A.-M., Rudkowska, I., Journal of Nutritional Biochemistry, 2013, 10.1016/j.jnutbio.2012.01.016
Supplementation with resveratrol and curcumin does not affect the inflammatory response to a high-fat meal in older adults with abdominal obesity: A randomized, placebo-controlled crossover trial, Lamarche, B., Couture, P., Vohl, M.-C., Marin, J., Gigleux, I., Paradis, M.-E., Couillard, C., Vors, C., Journal of Nutrition, 2018, 10.1093/jn/nxx072
Effects of neuromedin-β on caloric compensation, eating behaviours and habitual food intake, Pérusse, L., Vohl, M.-C., Bouchard, L., Couture, P., Lemieux, S., Blanchet, R., Appetite, 2011, 10.1016/j.appet.2011.04.003
Expression and sequence variants of inflammatory genes; Effects on plasma inflammation biomarkers following a 6-week supplementation with fish oil, Voh, M.-C., Couture, P., Lemieux, S., Rudkowska, I., Cormier, H., International Journal of Molecular Sciences, 2016, 10.3390/ijms17030375
Evidence that hepatic lipase deficiency in humans is not associated with proatherogenic changes in HDL composition and metabolism, Lamarche, B., Marcil, M., Bensadoun, A., Cohn, J.S., Couture, P., Ruel, I.L., Journal of Lipid Research, 2004, 10.1194/jlr.M400090-JLR200
Epigenetic changes in blood leukocytes following an omega-3 fatty acid supplementation, Vohl, M.-C., Couture, P., Lemieux, S., Rudkowska, I., Guénard, F., Tremblay, B.L., Clinical Epigenetics, 2017, 10.1186/s13148-017-0345-3
Common Variants in Lipid Metabolism–Related Genes Associate with Fat Mass Changes in Response to Dietary Monounsaturated Fatty Acids in Adults with Abdominal Obesity, Peter J H Jones, Peter Zahradka, Sandra Castillo, Angela Wilson, Danielle Perera, Carla G Taylor, David J A Jenkins, Kate J Bowen, Penny M Kris-Etherton, Sheila G West, Julie Maltais-Giguère, Valérie Guay, Patrick Couture, Benoît Lamarche, Philip W Connelly, Xiang Chen, Jyoti Sihag, Peter Eck, Shatha S Hammad, The Journal of Nutrition, 2019, 10.1093/jn/nxz136
Effect of buttermilk consumption on blood pressure in moderately hypercholesterolemic men and women, Lamarche, B., Pouliot, Y., Gauthier, S., Couture, P., Conway, V., Nutrition, 2014, 10.1016/j.nut.2013.07.021
Comprehensive review of the impact of dairy foods and dairy fat on cardiometabolic risk, Lamarche, B., Couture, P., Desroches, S., Tessier-Grenier, M., Brassard, D., Labonté, M., Côté, J.A., Drouin-Chartier, J.-P., Advances in Nutrition, 2016, 10.3945/an.115.011619
Imputation of baseline LDL cholesterol concentration in patients with familial hypercholesterolemia on statins or ezetimibe, Genest, J., John Mancini, G.B., Ryomoto, A., Brophy, J.M., Cermakova, L., Francis, G.A., Brunham, L.R., Brisson, D., Gaudet, D., Dufour, R., Baass, A., Wanneh, E., Bergeron, J., Couture, P., Hegele, R.A., De Varennes, É., Sadri, I., Aljenedil, S., Ruel, I., Clinical Chemistry, 2018, 10.1373/clinchem.2017.279422
Sex differences in the presentation, treatment and outcomes of patients with homozygous familial hypercholesterolemia, Liam R. Brunham, Jacques Genest, Ruth McPherson, Mark H. Sherman, Thomas Ransom, Brian W. McCrindle, G.B. John Mancini, Iulia Iatan, Robert A. Hegele, Gordon A. Francis, Daniel Gaudet, Patrick Couture, Lubomira Cermakova, Jean Bergeron, Alexis Baass, Isabelle Ruel, Leslie Brown, Zobaida Al-Baldawi, Journal of Clinical Lipidology, 2024, 10.1016/j.jacl.2024.01.003
SREBF1 gene variations modulate insulin sensitivity in response to a fish oil supplementation, Vohl, M.-C., Pérusse, L., Couture, P., Lemieux, S., Rudkowska, I., Bouchard-Mercier, A., Lipids in Health and Disease, 2014, 10.1186/1476-511X-13-152
Subdivision of the subcutaneous adipose tissue compartment and lipid-lipoprotein levels in women, Tchernof, A., Dupont, P., Couture, P., Deschênes, D., Obesity Research, 2003, 10.1038/oby.2003.64
Geographic distribution of French-Canadian low-density lipoprotein receptor gene mutations in the Province of Quebec, Després, J.-P., Lupien, P.J., Davignon, J., Brun, L.-D., Blaichman, S., Perron, P., Couture, P., Bergeron, J., Lambert, M., Tremblay, G., Gagné, C., Minnich, A., Torres, A.L., Gaudet, D., Roy, M., Moorjani, S., Vohl, M.-C., Clinical Genetics, 1997
Diets low in saturated fat with different unsaturated fatty acid profiles similarly increase serum-mediated cholesterol efflux from THP-1 macrophages in a population with or at risk for metabolic syndrome: The Canola Oil Multicenter Intervention Trial, Kris-Etherton, P.M., West, S.G., Fleming, J.A., Pu, S., Couture, P., Connelly, P.W., Jenkins, D.J., Lamarche, B., Heuvel, J.V., Jones, P.J., Garban, J., Liu, X., Journal of Nutrition, 2018, 10.1093/jn/nxy040
Differential effect of atorvastatin and fenofibrate on plasma oxidized low-density lipoprotein, inflammation markers, and cell adhesion molecules in patients with type 2 diabetes mellitus, Couture, P., Gagné, C., Bergeron, J., Tremblay, A.J., Lamarche, B., Hogue, J.-C., Metabolism: Clinical and Experimental, 2008, 10.1016/j.metabol.2007.10.014
Effect of the mediterranean diet with and without weight loss on markers of inflammation in men with metabolic syndrome, Desroches, S., Couture, P., Richard, C., Lamarche, B., Obesity, 2013, 10.1038/oby.2012.148
Contribution of receptor negative versus receptor defective mutations in the LDL-receptor gene to angiographically assessed coronary artery disease among young (25-49 years) versus middle-aged (50-64 years) men, Després, J.-P., Gagné, C., Perron, P., Tremblay, G., Moorjani, S., Couture, P., Vohl, M.-C., Gaudet, D., Atherosclerosis, 1999, 10.1016/S0021-9150(98)00268-8
Proceedings from the 2013 Canadian Nutrition Society Conference on Advances in Dietary Fats and Nutrition, Ma, D.W.L., Couture, P., Lamarche, B., Yan, W., Innis, S., Aliani, M., Rodriguez-Leyva, D., Pierce, G.N., Mutch, D.M., Holub, B., Applied Physiology, Nutrition and Metabolism, 2014, 10.1139/apnm-2013-0418
Impact of the Mediterranean diet with and without weight loss on plasma cell adhesion molecule concentrations in men with the metabolic syndrome, Lamarche, B., Couture, P., Desroches, S., Royer, M.-M., Couillard, C., Richard, C., Mediterranean Journal of Nutrition and Metabolism, 2011, 10.1007/s12349-010-0029-4
Omega-3 fatty acids regulate gene expression levels differently in subjects carrying the PPARα L162V polymorphism, Vohl, M.-C., Couture, P., Garenc, C., Rudkowska, I., Genes and Nutrition, 2009, 10.1007/s12263-009-0129-2
Long-term treatment with evolocumab added to conventional drug therapy, with or without apheresis, in patients with homozygous familial hypercholesterolaemia: an interim subset analysis of the open-label TAUSSIG study, Stein, E.A., Wasserman, S.M., Kasichayanula, S., Tang, L., Honarpour, N., Kurtz, C., Watts, G.F., Soran, H., Couture, P., Bruckert, E., Harada-Shiba, M., Santos, R.D., Blom, D., Hovingh, G.K., Raal, F.J., The Lancet Diabetes and Endocrinology, 2017, 10.1016/S2213-8587(17)30044-X
Impact of buttermilk consumption on plasma lipids and surrogate markers of cholesterol homeostasis in men and women, Lamarche, B., Pouliot, Y., Gauthier, S.F., Richard, C., Couture, P., Conway, V., Nutrition, Metabolism and Cardiovascular Diseases, 2013, 10.1016/j.numecd.2013.03.003
Influences of apolipoprotein E polymorphism on the response of plasma lipids to the ad libitum consumption of a high-carbohydrate diet compared with a high-monounsaturated fatty acid diet, Bergeron, N., Bergeron, J., Corneau, L., Dériaz, O., Landry, N., Lamarche, B., Archer, W.R., Couture, P., Metabolism: Clinical and Experimental, 2003, 10.1016/S0026-0495(03)00275-0
The effect of a dietary portfolio compared to a DASH-type diet on blood pressure, Kendall, C.W.C., Ramprasath, V., Couture, P., Josse, R., Leiter, L.A., Bashyam, B., Augustin, L.S., Jayalath, V.H., Mirrahimi, A., Sievenpiper, J.L., de Souza, R.J., Faulkner, D., Pellini, C., Galange, P., Srichaikul, K., Nishi, S.K., Ireland, C., Lamarche, B., Frohlich, J., Jones, P.J., Jenkins, D.J.A., Nutrition, Metabolism and Cardiovascular Diseases, 2015, 10.1016/j.numecd.2015.08.006
Effect of mediterranean diet with and without weight loss on apolipoprotein b100 metabolism in men with metabolic syndrome, Lamarche, B., Lichtenstein, A.H., Charest, A., Desroches, S., Tremblay, A.J., Ooi, E.M.M., Couture, P., Richard, C., Arteriosclerosis, Thrombosis, and Vascular Biology, 2014, 10.1161/ATVBAHA.113.302185
Traditional dietary pattern is associated with elevated cholesterol among the Inuit of Nunavik, Lamarche, B., Couture, P., Chateau-Degat, M.-L., Lucas, M., Dewailly, E., Labonté, M.-T., Journal of the Academy of Nutrition and Dietetics, 2014, 10.1016/j.jand.2013.12.017
Clinical and molecular characterization of a severe form of partial lipodystrophy expanding the phenotype of PPARγ deficiency, Gagné, C., Leff, T., Hegele, R.A., Couture, P., Bergeron, J., Martins, R., Astapova, O., Campeau, P.M., Journal of Lipid Research, 2012, 10.1194/jlr.P025437
Baseline plasma C-reactive protein concentrations influence lipid and lipoprotein responses to low-fat and high monounsaturated fatty acid diets in healthy men, Lamarche, B., Bergeron, N., Bergeron, J., Couture, P., Dériaz, O., Paradis, M.-E., Archer, W.R., Desroches, S., Journal of Nutrition, 2006
Genome-wide association study of the plasma triglyceride response to an n-3 polyunsaturated fatty acid supplementation, Vohl, M.-C., Minihane, A.M., Calder, P.C., Barbier, O., Lemieux, S., Couture, P., Julien, P., Guénard, F., Rudkowska, I., Journal of Lipid Research, 2014, 10.1194/jlr.M045898
Differential impact of the cheese matrix on the postprandial lipid response: A randomized, crossover, controlled trial, Couture, P., Turgeon, S.L., Lamarche, B., Britten, M., Labrie, S., Rioux, L.-E., Guinot, L., Charest, A., Maltais-Giguère, J., Tremblay, A.J., Drouin-Chartier, J.-P., American Journal of Clinical Nutrition, 2017, 10.3945/ajcn.117.165027
Effect of short-term low- and high-fat diets on low-density lipoprotein particle size in normolipidemic subjects, Couture, P., Tremblay, A.J., Charest, A., Lamarche, B., Guay, V., Metabolism: Clinical and Experimental, 2012, 10.1016/j.metabol.2011.06.002
Lipoprotein(a), Oxidized Phospholipids, and Aortic Valve Microcalcification Assessed by 18F-Sodium Fluoride Positron Emission Tomography and Computed Tomography, Arsenault, B.J., Clavel, M.-A., Pibarot, P., Thanassoulis, G., Tsimikas, S., Dweck, M.R., Mathieu, P., Couture, P., Witztum, J.L., Bossé, Y., Thériault, S., Engert, J.C., Nadeau, M., Guimond, J., Tessier, M., Trottier, M., Bourgeois, R., Chen, H.Y., Shen, M., Tastet, L., Poulin, A., Perrot, N., Després, A.-A., CJC Open, 2019, 10.1016/j.cjco.2019.03.004
Effect of the Mediterranean diet with and without weight loss on cardiovascular risk factors in men with the metabolic syndrome, Lamarche, B., Charest, A., Desroches, S., Couture, P., Richard, C., Nutrition, Metabolism and Cardiovascular Diseases, 2011, 10.1016/j.numecd.2010.01.012
The combination of single nucleotide polymorphisms rs6720173 (ABCG5), rs3808607 (CYP7A1), and rs760241 (DHCR7) is associated with differing serum cholesterol responses to dairy consumption, Jones, P.J.H., Lamarche, B., Couture, P., Eck, P.K., Abdullah, M.M.H., Applied Physiology, Nutrition and Metabolism, 2018, 10.1139/apnm-2018-0085
Modulation of C-reactive protein and plasma omega-6 fatty acid levels by phospholipase A2 gene polymorphisms following a 6-week supplementation with fish oil, Vohl, M.C., Julien, P., Lemieux, S., Couture, P., Rudkowska, I., Tremblay, B.L., Prostaglandins Leukotrienes and Essential Fatty Acids, 2015, 10.1016/j.plefa.2015.10.002
Extreme LDL-C concentration is associated with increased cardiovascular disease in women with homozygous familial hypercholesterolemia, Alexis Baass, Jacques Genest, Lulia Latan, Brian W McCrindle, GB John Mancini, Liam R Brunham, Thomas Ransom, Ruth McPherson, Mark H Sherman, Gordon A Francis, Robert A Hegele, Jean Bergeron, Patrick Couture, Daniel Gaudet, Diane Brisson, Zobaida Al-Baldawi, Simon-Pierre Guay, Isabelle Ruel, Martine Paquette, Journal of Clinical Lipidology, 2025, 10.1016/j.jacl.2024.10.008
2012 Update of the Canadian Cardiovascular Society Guidelines for the Diagnosis and Treatment of Dyslipidemia for the Prevention of Cardiovascular Disease in the Adult, Ur, E., Stone, J.A., Yates, G.M., Pearson, G.J., Ng, D.S., Lonn, E., Leiter, L.A., Ward, R., Gupta, M., Dufour, R., Carpentier, A.C., Genest, J., Grover, S., Lau, D.C., Poirier, P., Francis, G.A., McPherson, R., Mancini, G.B.J., Couture, P., Hegele, R.A., Grégoire, J., Anderson, T.J., Canadian Journal of Cardiology, 2013, 10.1016/j.cjca.2012.11.032
Associations between dairy intake and metabolic risk parameters in a healthy french-Canadian population, Rudkowska, I., Vohl, M.-C., Lemieux, S., Couture, P., Julien, P., Da Silva, M.S., Applied Physiology, Nutrition and Metabolism, 2014, 10.1139/apnm-2014-0154
Effects of fenofibrate on apolipoprotein kinetics in patients with coexisting dysbetalipoproteinemia and heterozygous familial hypercholesterolemia, Couture, P., Gagné, C., Deshaies, Y., Hogue, J.-C., Ruel, I.L., Lamarche, B., Tremblay, A.J., Atherosclerosis, 2006, 10.1016/j.atherosclerosis.2005.10.037
A common variant in ARHGEF10 alters delta-6 desaturase activity and influence susceptibility to hypertriglyceridemia, Vohl, M.-C., Couture, P., Lemieux, S., Rudkowska, I., Guénard, F., de Toro-Martín, J., Journal of Clinical Lipidology, 2018, 10.1016/j.jacl.2017.10.020
Plasma matrix metalloproteinase (mmp)-9 levels are reduced following low-calorie cranberry juice supplementation in men, Couillard, C., Couillard, C., Lemieux, S., Couture, P., Pomerleau, S., Ruel, G., Journal of the American College of Nutrition, 2009, 10.1080/07315724.2009.10719803
Influence of apolipoprotein E genotype on the reliability of the Friedewald formula in the estimation of low-density lipoprotein cholesterol concentrations, Couture, P., Gagné, C., Gagné, J.-M., Bergeron, J., Tremblay, A.J., Metabolism: Clinical and Experimental, 2005, 10.1016/j.metabol.2005.03.003
Endothelial lipase is associated with inflammation in humans, Lamarche, B., Bergeron, N., Archer, W.R., Couture, P., Deshaies, Y., Rader, D.J., Badellino, K.O., Paradis, M.-E., Journal of Lipid Research, 2006, 10.1194/jlr.P600002-JLR200
A randomized, crossover, head-to-head comparison of eicosapentaenoic acid and docosahexaenoic acid supplementation to reduce inflammation markers in men and women: The Comparing EPA to DHA (ComparED) Study, Lamarche, B., Tchernof, A., Talbot, D., Lépine, M.-C., Marin, J., Charest, A., Leclerc, M., Couture, P., Allaire, J., American Journal of Clinical Nutrition, 2016, 10.3945/ajcn.116.131896
Low-calorie cranberry juice supplementation reduces plasma oxidized LDL and cell adhesion molecule concentrations in men, Couillard, C., Lamarche, B., Lemieux, S., Couture, P., Pomerleau, S., Ruel, G., British Journal of Nutrition, 2008, 10.1017/S0007114507811986
Effect of an isoenergetic traditional Mediterranean diet on apolipoprotein A-I kinetic in men with metabolic syndrome, Lamarche, B., Lichtenstein, A.H., Desroches, S., Couture, P., Richard, C., Nutrition Journal, 2013, 10.1186/1475-2891-12-76
Carotenoids as biomarkers of fruit and vegetable intake in men and women, Lamarche, B., Couture, P., Vohl, M.-C., Lemieux, S., Couillard, C., British Journal of Nutrition, 2016, 10.1017/S0007114516003056
PCSK9 plays a significant role in cholesterol homeostasis and lipid transport in intestinal epithelial cells, Elchebly, M., Seidah, N.G., Ménard, D., Beaulieu, J.-F., Couture, P., Yara, S., Emonnot, L., Grenier, T., Garofalo, C., Sane, A.T., Spahis, S., Ouadda, A.B.D., Levy, E., Atherosclerosis, 2013, 10.1016/j.atherosclerosis.2013.01.023
Effect of weight loss, independent of change in diet composition, on apolipoprotein AI kinetic in men with metabolic syndrome, Lamarche, B., Lichtenstein, A.H., Desroches, S., Couture, P., Richard, C., Journal of Lipid Research, 2013, 10.1194/jlr.M029934
Severe debilitating xanthomatosis in a French-Canadian patient with heterozygous familial hypercholesterolemia, Gagné, C., Brun, L.-D., Couture, P., Carpentier, A., Endocrinologist, 1998
The c.419-420insA in the MTP gene is associated with abetalipoproteinemia among French-Canadians, Vohl, M.-C., Gaudet, D., Gagné, C., Verner, A., Deprés, J.-P., Sammak, A., Paradis, A.-M., Houde, A., Couture, P., Berthier, M.-T., Molecular Genetics and Metabolism, 2004, 10.1016/j.ymgme.2003.11.001
Impact of systemic enzyme supplementation on low-grade inflammation in humans, Lamarche, B., Vohl, M.-C., Paradis, M.-E., Couture, P., Gigleux, I., Marin, J., PharmaNutrition, 2015, 10.1016/j.phanu.2015.04.004
Effect of the PPAR-alpha L162V polymorphism on the cardiovascular disease risk factor in response to n-3 polyunsaturated fatty acids, Vohl, M.-C., Couture, P., Lemieux, S., Rudkowska, I., Paradis, A.-M., Paquet, P., Caron-Dorval, D., Journal of Nutrigenetics and Nutrigenomics, 2008, 10.1159/000137555
Adding MUFA to a dietary portfolio of cholesterol-lowering foods reduces apoAI fractional catabolic rate in subjects with dyslipidaemia, Lamarche, B., Couture, P., Hogue, J.-C., Kendall, C.W.C., Wong, J.M.W., Chiavaroli, L., Lewis, G.F., Jenkins, D.J.A., Labonté, M.-E., British Journal of Nutrition, 2013, 10.1017/S000711451200534X
Non-HDL cholesterol and apoB in dyslipidaemia, Couture, P., Gagné, C., Bergeron, J., Hogue, J.-C., Sniderman, A.D., Clinical Science, 2008, 10.1042/CS20070265
Effect of a six-week National Cholesterol Education Program step 1 diet on plasma sex hormone-binding globulin levels in overweight premenopausal women, Tchernof, A., Vohl, M.-C., Couture, P., Fontaine-Bisson, B., Bélanger, C., Robitaille, J., Blouin, K., Metabolic Syndrome and Related Disorders, 2007, 10.1089/met.2006.0005
Relations of change in plasma levels of LDL-C, non-HDL-C and apoB with risk reduction from statin therapy: a meta-analysis of randomized trials., Sniderman, A., Furberg, C.D., de Graaf, J., Lawler, P.R., Couture, P., Brook, R., Ye, K., Williams, K., Thanassoulis, G., Journal of the American Heart Association, 2014, 10.1161/JAHA.113.000759
Study of the effect of trans fatty acids from ruminants on blood lipids and other risk factors for cardiovascular disease, Lamarche, B., Couture, P., Lemieux, S., Chouinard, Y., Paquin, P., Grenier, G., Charest, A., Motard-Bélanger, A., American Journal of Clinical Nutrition, 2008
C-reactive protein levels are inversely correlated with the apolipoprotein B-48-containing triglyceride-rich lipoprotein production rate in insulin resistant men, Couture, P., Lamarche, B., Marin, J., Labonté, M.-È., Leclerc, M., Hogue, J.-C., Tremblay, A.J., Drouin-Chartier, J.-P., Metabolism: Clinical and Experimental, 2017, 10.1016/j.metabol.2016.11.019
Calculation of LDL apoB, Couture, P., De Graaf, J., Tremblay, A.J., Sniderman, A.D., Atherosclerosis, 2014, 10.1016/j.atherosclerosis.2014.03.012
The metabolic signature associated with the Western dietary pattern: A cross-sectional study, Vohl, M.-C., Couture, P., Lemieux, S., Rudkowska, I., Bouchard-Mercier, A., Nutrition Journal, 2013, 10.1186/1475-2891-12-158
Association of the Sst-I polymorphism at the APOC3 gene locus with variations in lipid levels, lipoprotein subclass profiles and coronary heart disease risk: The Framingham offspring study, Ordovas, J.M., Schaefer, E.J., Couture, P., Mallory, T., Cucinotta, D., Lahoz, C., Wilson, P.W.F, Otvos, J.D., Demissie, S., Cupples, L.Adrienne, Meigs, J.B., Russo, G.T., Atherosclerosis, 2001, 10.1016/S0021-9150(01)00409-9
Assessment of the validity of the frequently used lipid indices for predicting LDL peak particle diameter in a large cohort of 1955 normal and dyslipidemic subjects, Couture, P., Bergeron, J., Tremblay, A.J., Hogue, J.-C., Lamarche, B., Dumont, G., Décary, S., Clinical Biochemistry, 2010, 10.1016/j.clinbiochem.2009.11.010
Effect of sitagliptin therapy on triglyceride-rich lipoprotein kinetics in patients with type 2 diabetes, Couture, P., Droit, A., Lépine, M.-C., Charest, A., Kelly, I., Lamarche, B., Tremblay, A.J., Diabetes, Obesity and Metabolism, 2014, 10.1111/dom.12359
Key intestinal genes involved in lipoprotein metabolism are downregulated in dyslipidemic men with insulin resistance, Lamarche, B., Droit, A., Lemelin, V., Kelly, I., Tremblay, A.J., Couture, P., Journal of Lipid Research, 2014, 10.1194/jlr.M040071
Correlates of the difference in plasma carotenoid concentrations between men and women, Couillard, C., Lamarche, B., Couture, P., Vohl, M.-C., Lemieux, S., Allore, T., British Journal of Nutrition, 2019, 10.1017/S0007114518003045
Evaluation of iTRAQ and SWATH-MS for the quantification of proteins associated with insulin resistance in human duodenal biopsy samples, Droit, A., Couture, P., Lamarche, B., Lemelin, V., Tremblay, A., Kelly, I., Nehmé, B., Fournier, F., Bourassa, S., PLoS ONE, 2015, 10.1371/journal.pone.0125934
Plasma PCSK9 correlates with apoB-48-containing triglyceride-rich lipoprotein production in men with insulin resistance, Couture, P., Lamarche, B., Lemelin, V., Hogue, J.-C., Tremblay, A.J., Drouin-Chartier, J.-P., Journal of Lipid Research, 2018, 10.1194/jlr.M086264
Associations between dietary patterns and gene expression profiles of healthy men and women: A cross-sectional study, Vohl, M.-C., Couture, P., Lemieux, S., Rudkowska, I., Paradis, A.-M., Bouchard-Mercier, A., Nutrition Journal, 2013, 10.1186/1475-2891-12-24
N-3 polyunsaturated fatty acid supplementation has no effect on postprandial triglyceride-rich lipoprotein kinetics in men with type 2 diabetes, Couture, P., Hogue, J.-C., Lamarche, B., Tremblay, A.J., Journal of Diabetes Research, 2016, 10.1155/2016/2909210
Ethical issues in molecular screening for heterozygous familial hypercholesterolemia: The complexity of dealing with genetic susceptibility to coronary artery disease, Tonstad, S., Couture, P., Perron, P., Gagne, C., Gaudet, D., Community Genetics, 1999, 10.1159/000016176
Association of red blood cell n-3 polyunsaturated fatty acids with plasma inflammatory biomarkers among the Quebec Cree population, Lamarche, B., Couture, P., Lucas, M., Dewailly, É., Labonté, M.-È., European Journal of Clinical Nutrition, 2014, 10.1038/ejcn.2014.125
Association between polymorphisms in the fatty acid desaturase gene cluster and the plasma triacylglycerol response to an n-3 PUFA supplementation, Vohl, M.-C., Couture, P., Lemieux, S., Garneau, V., Thifault, E., Paradis, A.-M., Rudkowska, I., Cormier, H., Nutrients, 2012, 10.3390/nu4081026
Comparison of two low-density lipoprotein apheresis systems in patients with homozygous familial hypercholesterolemia, Couture, P., Lamarche, B., Laflamme, N., Pelletier, M., Bergeron, J., Tremblay, A.J., Drouin-Chartier, J.-P., Journal of Clinical Apheresis, 2016, 10.1002/jca.21406
Dairy product consumption has no impact on biomarkers of inflammation among men and women with low-grade systemic inflammation, Lamarche, B., Couture, P., Jones, P., Vohl, M.-C., Lépine, M.-C., Abdullah, M.M., Cyr, A., Labontè, M.-E., Journal of Nutrition, 2014, 10.3945/jn.114.200576
Atorvastatin increases intestinal expression of NPC1L1 in hyperlipidemic men, Couture, P., Davis Jr., H.R., Seidah, N.G., Benjannet, S., Hoos, L., Lemelin, V., Lamarche, B., Tremblay, A.J., Journal of Lipid Research, 2011, 10.1194/jlr.M011080
Effects of FADS and ELOVL polymorphisms on indexes of desaturase and elongase activities: Results from a pre-post fish oil supplementation, Couture, P., Vohl, M.-C., Julien, P., Lemieux, S., Rudkowska, I., Cormier, H., Genes and Nutrition, 2014, 10.1007/s12263-014-0437-z
3. High-density lipoprotein as a coronary heart disease risk factor and gene mutations affecting high-density lipoprotein cholesterol levels: Results from the Framingham Heart Study, Ordovas, J.M., Wilson, P.W.F., Cupples, L.A., Russo, G., Cendoroglo, M., Couture, P., Lahoz, C., Schaefer, E.J., Atherosclerosis, 1999, 10.1016/S0021-9150(99)00225-7
Phenotypes of hypertriglyceridemia caused by excess very-low-density lipoprotein, Couture, P., De Graaf, J., Tremblay, A., Sniderman, A.D., Journal of Clinical Lipidology, 2012, 10.1016/j.jacl.2012.04.081
Effect of an isoenergetic traditional mediterranean diet on the high-density lipoprotein proteome in men with the metabolic syndrome, Lamarche, B., Droit, A., Bourassa, S., Nehmé, B., Desroches, S., Couture, P., Richard, C., Journal of Nutrigenetics and Nutrigenomics, 2014, 10.1159/000363137
Intravascular kinetics of C-reactive protein and their relationships with features of the metabolic syndrome, Lamarche, B., Couture, P., Tchernof, A., Bergeron, N., Paradis, M.-E., Lévesque, J., Mauger, J.-F., Journal of Clinical Endocrinology and Metabolism, 2008, 10.1210/jc.2007-2585
High-density lipoprotein subpopulation profiles in lipoprotein lipase and hepatic lipase deficiency, Asztalos, B.F., Schaefer, E.J., Burnett, J.R., Couture, P., Lamarche, B., Horvath, K.V., Tani, M., Atherosclerosis, 2016, 10.1016/j.atherosclerosis.2016.08.014
Population-based study of high plasma C-reactive protein concentrations among the Inuit of Nunavik, Lamarche, B., Couture, P., Chateau-Degat, M.-L., Dewailly, E., Labonté, M.-E., International Journal of Circumpolar Health, 2012, 10.3402/ijch.v71i0.19066
Differential associations between plasma concentrations of insulin and glucose and intestinal expression of key genes involved in chylomicron metabolism, Couture, P., Lamarche, B., Lemelin, V., Tremblay, A.J., Drouin-Chartier, J.-P., American Journal of Physiology - Gastrointestinal and Liver Physiology, 2018, 10.1152/ajpgi.00108.2018
Consumption of a dietary portfolio of cholesterol lowering foods improves blood lipids without affecting concentrations of fat soluble compounds, Jones, P.J., Frohlich, J., Connelly, P.W., Leiter, L.A., Josse, R.G., Vidgen, E., de Souza, R.J., Srichaikul, K., Bashyam, B., Patel, D., Abdulnour, S., Ireland, C., Couture, P., Cermakova, L., Faulkner, D., Kendall, C.W., Lamarche, B., Jenkins, D.J., Ramprasath, V.R., Nutrition journal, 2014, 10.1186/1475-2891-13-101
Regulation of plasma LDL: The apoB paradigm, Watts, G.F., Kiss, R.S., Williams, K., Couture, P., De Graaf, J., Sniderman, A.D., Clinical Science, 2010, 10.1042/CS20090402
Eicosapentaenoic and docosahexaenoic acid supplementation and inflammatory gene expression in the duodenum of obese patients with type 2 diabetes, Lamarche, B., Lemelin, V., Hogue, J.-C., Tremblay, A.J., Couture, P., Labonté, M.-E., Nutrition Journal, 2013, 10.1186/1475-2891-12-98
Aortic calcifications in familial hypercholesterolemia: Potential role of the low-density lipoprotein receptor gene, Genest, J., Couture, P., Valenti, D., Awan, Z., Alwaili, K., Alrasadi, K., American Heart Journal, 2009, 10.1016/j.ahj.2008.08.021
Low-density lipoprotein-lowering strategies: Target versus maximalist versus population percentile, Couture, P., De Graaf, J., Sniderman, A.D., Current Opinion in Cardiology, 2012, 10.1097/HCO.0b013e328353fed5
Comparing interviewer-administered and web- based food frequency questionnaires to predict energy requirements in adults, Lamarche, B., Labonté, M.-È., Couture, P., Lapointe, A., Charest, A., Lemieux, S., Brassard, D., Nutrients, 2018, 10.3390/nu10091292
Correlates of reactive hyperemic index in men and postmenopausal women, Couillard, C., Lamarche, B., Jones, P.J., Couture, P., Ramprasath, V.R., Gigleux, I., Paradis, M.-E., Carnovale, V., Vascular Medicine (United Kingdom), 2013, 10.1177/1358863X13507975
Differential impact of plasma triglycerides on HDL-cholesterol and HDL-apo A-I in a large cohort, Couture, P., Bergeron, J., Gagné, C., Sniderman, A.D., Tremblay, A.J., Clinical Biochemistry, 2007, 10.1016/j.clinbiochem.2006.06.014
Canadian Cardiovascular Society Position Statement onFamilial Hypercholesterolemia, St-Pierre, J., Ruel, I., Raggi, P., McCrindle, B., Mancini, J., Krisnamoorthy, P., Gupta, M., Gaudet, D., Frohlich, J., Dufour, R., Davignon, J., Couture, P., Carpentier, A., Brophy, J., Bergeron, J., Hegele, R.A., Genest, J., Canadian Journal of Cardiology, 2014, 10.1016/j.cjca.2014.09.028
Apolipoprotein C-III isoforms: Kinetics and relative implication in lipid metabolism, Lamarche, B., Bergeron, N., Couture, P., Mauger, J.-F., Journal of Lipid Research, 2006, 10.1194/jlr.M500455-JLR200
The Lifelong Burden of Homozygous Familial Hypercholesterolemia, Genest, J., Ruel, I., Bélanger, A.M., Bergeron, J., Couture, P., Alothman, L., Banerjee, A., Canadian Journal of Cardiology, 2019, 10.1016/j.cjca.2019.06.009
Association between polymorphisms in phospholipase A2 genes and the plasma triglyceride response to an n-3 PUFA supplementation: A clinical trial, Vohl, M.-C., Couture, P., Lemieux, S., Rudkowska, I., Cormier, H., Tremblay, B.L., Lipids in Health and Disease, 2015, 10.1186/s12944-015-0009-2
Evidence of increased secretion of apolipoprotein B-48-containing lipoproteins in subjects with type 2 diabetes, Couture, P., Gagné, C., Bergeron, J., Tremblay, A.J., Lamarche, B., Hogue, J.-C., Journal of Lipid Research, 2007, 10.1194/jlr.M600548-JLR200
Variance in the composition and number of VLDL and LDL particles with increasing triglyceride or increasing ApoB concentrations, Allan D. Sniderman, André J. Tremblay, Patrick Couture, Justine Cole, Journal of Clinical Lipidology, 2025, 10.1016/j.jacl.2024.09.009
Relationship between cholesteryl ester transfer protein and LDL heterogeneity in familial hypercholesterolemia, Couture, P., Gagné, C., Després, J.-P., Lemieux, I., Bergeron, J., Tremblay, A.J., Larivière, M., Gaudet, D., Lamarche, B., Hogue, J.-C., Journal of Lipid Research, 2004, 10.1194/jlr.M300420-JLR200
Counterpoint: Statins do reduce fatal events, Furberg, C.D., Alam, A., Williams, K., Couture, P., Thanassoulis, G., Sniderman, A.D., Journal of Clinical Lipidology, 2013, 10.1016/j.jacl.2012.12.004
Comparison of the impact of trans fatty acids from ruminant and industrial sources on surrogate markers of cholesterol homeostasis in healthy men, Lamarche, B., Lemieux, S., Chouinard, Y., Paquin, P., Couture, P., Labonté, M.-E., Molecular Nutrition and Food Research, 2011, 10.1002/mnfr.201000492
Relationship between lifestyle habits and cardiovascular risk factors in familial hypercholesterolemia, Jean-Philippe Drouin-Chartier, Angelo Tremblay, Louis Pérusse, Marta Guasch-Ferré, Anne Gangloff, Patrick Couture, Gabrielle Roy, Laurie Dessureault, Nutrition, Metabolism and Cardiovascular Diseases, 2023, 10.1016/j.numecd.2023.06.014
Effect of sitagliptin therapy on postprandial lipoprotein levels in patients with type 2 diabetes, Couture, P., Weisnagel, S.J., Deacon, C.F., Lamarche, B., Tremblay, A.J., Diabetes, Obesity and Metabolism, 2011, 10.1111/j.1463-1326.2011.01362.x
Apolipoprotein A-I, A-II, and VLDL-B-100 metabolism in men: Comparison of a low-fat diet and a high-monounsaturated fatty acid diet, Lamarche, B., Bergeron, N., Couture, P., Bergeron, J., Archer, W.R., Pérusse, M., Paradis, M.-E., Desroches, S., Journal of Lipid Research, 2004, 10.1194/jlr.M400287-JLR200
Plasma n-3 fatty acid response to an n-3 fatty acid supplement is modulated by apoE 4 but not by the common PPAR- L162V polymorphism in men, Cunnane, S.C., Lemieux, S., Couture, P., Vandal, M., Vohl, M.-C., Plourde, M., British Journal of Nutrition, 2009, 10.1017/S000711450938215X
Kinetics of plasma apolipoprotein C-III as a determinant of diet-induced changes in plasma triglyceride levels, Lamarche, B., Bergeron, N., Couture, P., Archer, W.R., Paradis, M.-E., Deshaies, Y., Ruel, I.L., Desroches, S., European Journal of Clinical Nutrition, 2008, 10.1038/sj.ejcn.1602673
Diagnosis and treatment of apolipoprotein B dyslipoproteinemias, De Graaf, J., Couture, P., Sniderman, A., Nature Reviews Endocrinology, 2010, 10.1038/nrendo.2010.50
Polymorphisms in Fatty Acid Desaturase (FADS) gene cluster: Effects on glycemic controls following an omega-3 Polyunsaturated Fatty Acids (PUFA) supplementation, Vohl, M.-C., Couture, P., Lemieux, S., Thifault, E., Rudkowska, I., Cormier, H., Genes, 2013, 10.3390/genes4030485
Diets enriched with conventional or high-oleic acid canola oils lower atherogenic lipids and lipoproteins compared to a diet with a western fatty acid profile in adults with central adiposity, Jones, P.J.H., Rempel, J., Juan, S.C.S., Wilson, A., Perera, D., Maltais-Giguère, J., Guay, V., Chen, X., Sihag, J., Hammad, S.S., Zahradka, P., Taylor, C.G., Jenkins, D.J.A., Couture, P., Lamarche, B., Connelly, P.W., Fleming, J.A., West, S.G., Kris-Etherton, P.M., Bowen, K.J., Journal of Nutrition, 2019, 10.1093/jn/nxy307
The low-density lipoprotein receptor genotype is a significant determinant of the rebound in low-density lipoprotein cholesterol concentration after lipoprotein apheresis among patients with homozygous familial hypercholesterolemia, Couture, P., Lamarche, B., Bergeron, J., Tremblay, A.J., Drouin-Chartier, J.-P., Circulation, 2017, 10.1161/CIRCULATIONAHA.117.029435
Systematic review of the association between dairy product consumption and risk of cardiovascular-related clinical outcomes, Lamarche, B., Couture, P., Desroches, S., Labonté, M., Côté, J.A., Tessier-Grenier, M., Brassard, D., Drouin-Chartier, J.-P., Advances in Nutrition, 2016, 10.3945/an.115.011403
Differential effect of fenofibrate and atorvastatin on in vivo kinetics of apolipoproteins B-100 and B-48 in subjects with type 2 diabetes mellitus with marked hypertriglyceridemia, Couture, P., Gagné, C., Bergeron, J., Tremblay, A.J., Deshaies, Y., Lamarche, B., Hogue, J.-C., Metabolism: Clinical and Experimental, 2008, 10.1016/j.metabol.2007.09.008
Dietary fat intake determines the effect of a common polymorphism in the hepatic lipase gene promoter on high-density lipoprotein metabolism: Evidence of a strong dose effect in this gene-nutrient interaction in the Framingham study, Tucker, K.L., Schaefer, E.J., Wilson, P.W.F., Coltell, O., Couture, P., Cupples, L.A., Demissie, S., Corella, D., Ordovas, J.M., Circulation, 2002, 10.1161/01.CIR.0000036597.52291.C9
Effects of atorvastatin on electrophoretic characteristics of LDL particles among subjects with heterozygous familial hypercholesterolemia, Couture, P., Gagné, C., Bergeron, J., Hogue, J.-C., Pirro, M., Lamarche, B., Larivière, M., Atherosclerosis, 2003, 10.1016/S0021-9150(02)00385-4
Docosahexaenoic acid-enriched canola oil increases adiponectin concentrations: A randomized crossover controlled intervention trial, Lamarche, B., Fleming, J.A., Jones, P.J., Kris-Etherton, P.M., West, S., Connelly, P.W., Jenkins, D.A., Guay, V., Charest, A., Vohl, M.-C., Couture, P., Labonté, M.-E., Baril-Gravel, L., Nutrition, Metabolism and Cardiovascular Diseases, 2015, 10.1016/j.numecd.2014.08.003
Familial hypercholesterolemia in Canada: Initial results from the FH Canada national registry, Genest, J., Gaudet, D., Brisson, D., Brophy, J.M., Mancini, G.B.J., Cermakova, L., Francis, G.A., Dufour, R., Baass, A., Bergeron, J., Couture, P., Hegele, R.A., Khoury, E., Ruel, I., Brunham, L.R., Atherosclerosis, 2018, 10.1016/j.atherosclerosis.2018.05.040
Short-term, high-fat diet increases the expression of key intestinal genes involved in lipoprotein metabolism in healthy men, Couture, P., Lemelin, V., Charest, A., Guay, V., Lamarche, B., Tremblay, A.J., American Journal of Clinical Nutrition, 2013, 10.3945/ajcn.113.060251
2016 Canadian Cardiovascular Society Guidelines for the Management of Dyslipidemia for the Prevention of Cardiovascular Disease in the Adult, Ward, R., Thanassoulis, G., Stone, J.A., Sievenpiper, J.L., Poirier, P., Ngui, D., McPherson, R., Mancini, G.B.J., Lonn, E., Leiter, L.A., Lau, D.C., Hegele, R.A., Gupta, M., Grover, S., Genest, J., Francis, G.A., Dawes, M., Couture, P., Barry, A.R., Pearson, G.J., Grégoire, J., Anderson, T.J., Canadian Journal of Cardiology, 2016, 10.1016/j.cjca.2016.07.510
Associations between hypertriglyceridemia, dietary fat intake, oxidative stress, and endothelial activation in men, Bergeron, N., Lamarche, B., Couture, P., Bergeron, J., Archer, W.R., Ruel, G., Pomerleau, S., Couillard, C., Nutrition, 2006, 10.1016/j.nut.2006.03.007
Association of heterozygous familial hypercholesterolemia with smaller HDL particle size, Couture, P., Gagné, C., Bergeron, J., Després, J.-P., Tremblay, A.J., Gaudet, D., Lamarche, B., Hogue, J.-C., Atherosclerosis, 2007, 10.1016/j.atherosclerosis.2006.02.023
Changes in high-density lipoprotein-carried miRNA contribution to the plasmatic pool after consumption of dietary trans fat in healthy men, Bouchard, L., Lamarche, B., Couture, P., Corbin, F., Guay, S.-P., Guérin, R., Desgagné, V., Epigenomics, 2017, 10.2217/epi-2016-0177
The T111I mutation in the EL gene modulates the impact of dietary fat on the HDL profile in women, Lamarche, B., Vohl, M.-C., Bouchard, C., Pérusse, L., Després, J.-P., Bossé, Y., Couture, P., Paradis, M.-E., Journal of Lipid Research, 2003, 10.1194/jlr.M300118-JLR200
Plasma metabolism of apoB-containing lipoproteins in patients with hepatic lipase deficiency, Lamarche, B., Cohn, J.S., Couture, P., Ruel, I.L., Atherosclerosis, 2005, 10.1016/j.atherosclerosis.2004.12.014
Ezetimibe increases intestinal expression of the LDL receptor gene in dyslipidaemic men with insulin resistance, Couture, P., Lamarche, B., Lépine, M.-C., Lemelin, V., Tremblay, A.J., Drouin-Chartier, J.-P., Diabetes, Obesity and Metabolism, 2016, 10.1111/dom.12749
High carbohydrate and high monounsaturated fatty acid diets similarly affect LDL electrophoretic characteristics in men who are losing weight, Bergeron, N., Couture, P., Bergeron, J., Després, J.-P., Corneau, L., Landry, N., Dériaz, O., Mauger, J.-F., St-Pierre, A.C., Lamarche, B., Archer, W.R., Journal of Nutrition, 2003
Dietary fatty acids, dietary patterns, and lipoprotein metabolism, Couture, P., Lamarche, B., Current Opinion in Lipidology, 2015, 10.1097/MOL.0000000000000139
Effect of the Mediterranean diet on plasma adipokine concentrations in men with metabolic syndrome, Lamarche, B., Cianflone, K., Rezvani, R., Desroches, S., Couture, P., Royer, M.-M., Richard, C., Metabolism: Clinical and Experimental, 2013, 10.1016/j.metabol.2013.07.012
Effects of sitagliptin therapy on markers of low-grade inflammation and cell adhesion molecules in patients with type 2 diabetes, Couture, P., Weisnagel, S.J., Deacon, C.F., Lamarche, B., Tremblay, A.J., Metabolism: Clinical and Experimental, 2014, 10.1016/j.metabol.2014.06.004
Plasma triglyceride levels may be modulated by gene expression of IQCJ, NXPH1, PHF17 and MYB in humans, Vohl, M.-C., Rudkowska, I., Couture, P., Lemieux, S., Cormier, H., Guénard, F., Marcotte, B.V., International Journal of Molecular Sciences, 2017, 10.3390/ijms18020257
2009 Canadian Cardiovascular Society/Canadian guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the adult - 2009 recommendations, Ur, E., Stone, J.A., Sniderman, A., Pearson, G.J., Ng, D., Mancini, G.B.J., Lonn, E., Lewis, G.F., Leiter, L., Lau, D.C., Hegele, R.A., Gupta, M., Grover, S., Francis, G.A., Fodor, G., Dufour, R., Couture, P., Carpentier, A., Campbell, N., Anderson, T., Frohlich, J., McPherson, R., Genest, J., Canadian Journal of Cardiology, 2009, 10.1016/S0828-282X(09)70715-9
Impact of the Mediterranean Diet on Features of Metabolic Syndrome: Is Weight Loss Required?, Lamarche, B., Couture, P., Richard, C., The Mediterranean Diet: An Evidence-Based Approach, 2014, 10.1016/B978-0-12-407849-9.00030-0
Genome-wide association study of dietary pattern scores, Vohl, M.-C., Couture, P., Lemieux, S., Rudkowska, I., Bouchard-Mercier, A., Guénard, F., Nutrients, 2017, 10.3390/nu9070649
Impact of lipoprotein apheresis with dextran-sulfate adsorption on the expression of genes involved in cardiovascular health in the blood of patients with homozygous familial hypercholesterolemia, Couture, P., Lamarche, B., Laflamme, N., Bergeron, J., Tremblay, A.J., Drouin-Chartier, J.-P., Journal of Clinical Apheresis, 2018, 10.1002/jca.21569
It is time to revisit current dietary recommendations for saturated fat, Couture, P., Lamarche, B., Applied Physiology, Nutrition and Metabolism, 2014, 10.1139/apnm-2014-0141
Variations in body composition and plasma lipids in response to a high-carbohydrate diet, Bergeron, N., Couture, P., Bergeron, J., Després, J.-P., Corneau, L., Landry, N., Dériaz, O., Lamarche, B., Archer, W.R., Obesity Research, 2003, 10.1038/oby.2003.135
Fine mapping of low-density lipoprotein receptor gene by genetic linkage on chromosome 19p13.1-p13.3 and study of the founder effect of four French Canadian low-density lipoprotein receptor gene mutations, Simard, J., Després, J.-P., Bergeron, J., Gagné, C., Vohl, M.-C., Gaudet, D., Morissette, J., Couture, P., Atherosclerosis, 1999, 10.1016/S0021-9150(98)00267-6
Associations between insulin-like growth factor binding protein-2 and lipoprotein kinetics in men, Frédéric Picard, Patrick Couture, André J. Tremblay, Benoît Lamarche, Chloé Rauzier, Journal of Lipid Research, 2022, 10.1016/j.jlr.2022.100269
Apo B versus cholesterol in estimating cardiovascular risk and in guiding therapy: Report of the thirty-person/ten-country panel, Williams, K.M.S., Walldius, G., Tonkin, A.M., Talmud, P.J., Stein, E., Stalenhoef, A.F., Sniderman, A.D., Sarrafzadegan, N., Rosenson, R., Reddy, K.S., Pearson, T.A., Packard, C.J., Marcovina, S., Kwiterovich, P., Krauss, R.M., Jungner, I., Humphries, S.E., Haffner, S.M., Gagne, C., Furberg, C.D., Frohlich, J., Faergeman, O., Durrington, P.N., De Graaf, J., Couture, P., Chapman, M.J., Cabezas, M.C., Carmena, R., Ballantyne, C.M., Barter, P.J., Journal of Internal Medicine, 2006, 10.1111/j.1365-2796.2006.01616.x
Increased production of VLDL apoB-100 in subjects with familial hypercholesterolemia carrying the same null LDL receptor gene mutation, Couture, P., Gagné, C., Bergeron, J., Hogue, J.-C., Ruel, I.L., Lamarche, B., Tremblay, A.J., Journal of Lipid Research, 2004, 10.1194/jlr.M300448-JLR200
Androgen receptor-mediated stimulation of 17β-hydroxysteroid dehydrogenase activity by dihydrotestosterone and medroxyprogesterone acetate in zr-75-1 human breast cancer cells, Labrie, F., Simardj, J., Theriault, C., Couture, P., Endocrinology, 1993, 10.1210/endo.132.1.8380373
Saturated fats from butter but not from cheese increase HDL-Mediated cholesterol efflux capacity from J774 macrophages in men and women with abdominal obesity, Lamarche, B., Couture, P., Jones, P.J.H., Asztalos, B., Levy, E., Tremblay, A., Talbot, D., Tessier-Grenier, M., Bernic, D., Boyer, M., Arsenault, B.J., Brassard, D., Journal of Nutrition, 2018, 10.1093/jn/nxy014
Canadian Cardiovascular Society Position Statement on Familial Hypercholesterolemia: Update 2018, Brophy, J., Bewick, D., Joy, T.R., Katz, P., Bernard, S., Ransom, T., Romney, J., Paré, G., Gaudet, D., Goguen, J., Genest, J., Hegele, R.A., Henderson, M., St-Pierre, J., Morrison, K., McCrindle, B.W., Francis, G.A., Bergeron, J., Pearson, G.J., Couture, P., Gupta, M., Raggi, P., Mancini, G.B.J., Tu, J.V., Baass, A., Rivière, J.-B., Aljenedil, S., Ruel, I., Brunham, L.R., Canadian Journal of Cardiology, 2018, 10.1016/j.cjca.2018.09.005
Lomitapide for treatment of homozygous familial hypercholesterolemia: The Québec experience, Jacques Genest, Daniel Gaudet, Etienne Khoury, Diane Brisson, Isabelle Ruel, Alexis Baass, Patrick Couture, Jean Bergeron, Zubin Lahijanian, Leslie Brown, Alexandre M. Bélanger, Latifah Alothman, Sumayah Aljenedil, Atherosclerosis, 2020, 10.1016/j.atherosclerosis.2020.07.028
Effects of age, sex, body mass index and APOE genotype on cardiovascular biomarker response to an n-3 polyunsaturated fatty acid supplementation, Vohl, M.-C., Couture, P., Lemieux, S., Ouellette, C., Garneau, V., Paradis, A.-M., Rudkowska, I., Bouchard-Mercier, A., Cormier, H., Thifault, E., Journal of Nutrigenetics and Nutrigenomics, 2013, 10.1159/000350744
Simplified Canadian Definition for Familial Hypercholesterolemia, Genest, J., Watts, G.F., Tu, J.V., Raggi, P., Pang, J., McCrindle, B.W., Mancini, G.B.J., Hegele, R.A., Gupta, M., Grégoire, J.C., Gaudet, D., Gagné, C., Frohlich, J., Francis, G.A., Dufour, R., Couture, P., Brunham, L.R., Brophy, J.M., Bewick, D., Bergeron, J., Bélanger, A., Baass, A., Awan, Z., Aljenedil, S., Brisson, D., Ruel, I., Canadian Journal of Cardiology, 2018, 10.1016/j.cjca.2018.05.015
Comparison of the impact of atorvastatin and simvastatin on apoA-I kinetics in men, Lamarche, B., Paradis, M.-E., Couture, P., Mauger, J.-F., Atherosclerosis, 2005, 10.1016/j.atherosclerosis.2004.06.022
Lifestyle recommendations for the prevention and management of metabolic syndrome: An international panel recommendation, López-Miranda, J., Ros, E., Wopereis, S., van Ommen, B., de la Torre, R., Tinahones, F.J., Schrö der, H., Salas-Salvadó, J., Rizzo, M., Pérez-Jiménez, F., Ordovás, J.M., Nikolic, D., Muñoz-Garach, A., Mena-Sánchez, G., Maiorino, M.I., Lamarche, B., Kolovou, G., Katsiki, N., García-Ríos, A., Giugliano, D., Garaulet, M., Fitó, M., Esposito, K., Estruch, R., Drevon, C.A., Díaz-López, A., Delgado-Lista, J., de Koning, L., Covas, M.I., Couture, P., Bullo, M., Athyros, V.G., Mikhailidis, D.P., Pérez-Martínez, P., Nutrition Reviews, 2017, 10.1093/nutrit/nux014
Variations in plasma apolipoprotein C-III levels are strong correlates of the triglyceride response to a high-monounsaturated fatty acid diet and a high-carbohydrate diet, Bergeron, N., Couture, P., Bergeron, J., Fontaine-Bisson, B., Landry, N., Dériaz, O., Lamarche, B., Desroches, S., Archer, W.R., Metabolism: Clinical and Experimental, 2005, 10.1016/j.metabol.2005.05.004
Type I protein C deficiency in French Canadians: Evidence of a founder effect and association of specific protein C gene mutations with plasma protein C levels, Simard, J., Couture, L., Jomphe, M., Delage, R., Morissette, J., Demers, C., Couture, P., Thrombosis and Haemostasis, 1998
Substitution of dietary ω-6 polyunsaturated fatty acids for saturated fatty acids decreases LDL apolipoprotein B-100 production rate in men with dyslipidemia associated with insulin resistance: A randomized controlled trial, Couture, P., Lamarche, B., Lemelin, V., Lépine, M.-C., Tremblay, A.J., Drouin-Chartier, J.-P., American Journal of Clinical Nutrition, 2018, 10.1093/ajcn/nqx013
Effects of the mediterranean diet before and after weight loss on eating behavioral traits in men with metabolic syndrome, Lamarche, B., Lemieux, S., Desroches, S., Couture, P., Richard, C., Royer, M.-M., Carbonneau, É., Nutrients, 2017, 10.3390/nu9030305
Does lifestyle contribute to disease severity in patients with inherited lipid disorders?, Couture, P., Perrot, N., Arsenault, B.J., Current Opinion in Lipidology, 2017, 10.1097/MOL.0000000000000387
Dietary medium-chain triglyceride supplementation has no effect on apolipoprotein B-48 and apolipoprotein B-100 kinetics in insulin-resistant men, Couture, P., Lemelin, V., Lépine, M.-C., Labonté, M.-E., Lamarche, B., Tremblay, A.J., American Journal of Clinical Nutrition, 2014, 10.3945/ajcn.113.068767
Effect of fenofibrate on plasma lipoprotein composition and kinetics in patients with complete hepatic lipase deficiency, Couture, P., Marcil, M., Cohn, J.S., Badellino, K.O., Mauger, J.-F., Lamarche, B., Ruel, I.L., Arteriosclerosis, Thrombosis, and Vascular Biology, 2005, 10.1161/01.ATV.0000190700.76493.bb
Effects of canola and high-oleic-acid canola oils on abdominal fat mass in individuals with central obesity, Jones, P.J.H., Connelly, P.W., Couture, P., Pu, S., McCrea, C.E., Fleming, J.A., Jenkins, D.J.A., Lamarche, B., West, S.G., Kris-Etherton, P.M., Liu, X., Obesity, 2016, 10.1002/oby.21584
Association of the C-514T polymorphism in the hepatic lipase gene with variations in lipoprotein subclass profiles: The Framingham Offspring Study, Ordovas, J.M., Schaefer, E.J., Wilson, P.W.F., Lahoz, C., Cupples, L.A., Otvos, J.D., Couture, P., Arteriosclerosis, Thrombosis, and Vascular Biology, 2000, 10.1161/01.ATV.20.3.815
Comparing the serum TAG response to high-dose supplementation of either DHA or EPA among individuals with increased cardiovascular risk: The ComparED study, Lamarche, B., Couture, P., Tchernof, A., Jackson, K.H., Harris, W.S., Vors, C., Allaire, J., British Journal of Nutrition, 2019, 10.1017/S0007114519000552
Vascular calcifications in homozygote familial hypercholesterolemia, Couture, P., Genest, J., Gagne, C., Marcil, M., De Varennes, B., Valenti, D., Frohlich, J., McPherson, R., Hegele, R.A., Francis, G.A., Alrasadi, K., Awan, Z., Arteriosclerosis, Thrombosis, and Vascular Biology, 2008, 10.1161/ATVBAHA.107.160408
Diagnosis of type III hyperlipoproteinemia from plasma total cholesterol, triglyceride, and apolipoprotein B, Couture, P., Gagné, C., Bergeron, J., Tremblay, A., Sniderman, A., Journal of Clinical Lipidology, 2007, 10.1016/j.jacl.2007.07.006
Impact of dairy consumption on essential hypertension: A clinical study, Couture, P., Lamarche, B., Poirier, L., Tremblay, A.J., Gigleux, I., Drouin-Chartier, J.-P., Nutrition Journal, 2014, 10.1186/1475-2891-13-83
An interaction effect between glucokinase gene variation and carbohydrate intakes modulates the plasma triglyceride response to a fish oil supplementation, Vohl, M.-C., Couture, P., Lemieux, S., Rudkowska, I., Bouchard-Mercier, A., Genes and Nutrition, 2014, 10.1007/s12263-014-0395-5
Visceral adiposity and endothelial lipase, Lamarche, B., Bergeron, N., Couture, P., Archer, W.R., Bergeron, J., Deshaies, Y., Luu-The, V., Richard, C., Tchernof, A., Rader, D.J., Badellino, K.O., Paradis, M.-E., Journal of Clinical Endocrinology and Metabolism, 2006, 10.1210/jc.2006-0766
Changes in plasma antioxidant capacity and oxidized low-density lipoprotein levels in men after short-term cranberry juice consumption, Couillard, C., Lamarche, B., Couture, P., Pomerleau, S., Ruel, G., Metabolism: Clinical and Experimental, 2005, 10.1016/j.metabol.2005.01.031
Are the ACC/AHA Guidelines on the Treatment of Blood Cholesterol a Game Changer? A Perspective From the Canadian Cardiovascular Society Dyslipidemia Panel, Ur, E., Stone, J.A., Yates, G.M., Pearson, G.J., Ng, D.S., Lonn, E., Leiter, L.A., Ward, R., Gupta, M., Dufour, R., Carpentier, A.C., Genest, J., Grover, S., Lau, D.C., Poirier, P., Francis, G.A., McPherson, R., Mancini, G.B.J., Couture, P., Hegele, R.A., Grégoire, J., Anderson, T.J., Canadian Journal of Cardiology, 2014, 10.1016/j.cjca.2014.01.009
Ezetimibe and bile acid sequestrants: Impact on lipoprotein metabolism and beyond, Lamarche, B., Couture, P., Current Opinion in Lipidology, 2013, 10.1097/MOL.0b013e3283613a55
Rapid restriction fragment analysis for screening four point mutations of the Low‐density lipoprotein receptor gene in French Canadians, Simard, J., Labrie, F., Lupien, P.J., Després, J.‐P., Gagné, C., Torres, A.L., Moorjani, S., Couture, P., Vohl, M.‐C., Human Mutation, 1995, 10.1002/humu.1380060307
Hyperlipidemia as the first biochemical manifestation of primary hepatic amyloidosis, Gagné, C., Gagnon, O., Gagnon, P., LeBlanc, F., Couture, P., American Journal of Gastroenterology, 1997
Detection of a novel mutation (stop 468) in exon 10 of the low-density lipoprotein receptor gene causing familial hypercholesterolemia among french canadians, Lupien, P.J., Labrie, F., Després, J.-P., Gagné, C., Torres, A.L., Couture, P., Vohl, M.-C., Moorjani, S., Simard, J., Human Molecular Genetics, 1994, 10.1093/hmg/3.9.1689
Evidence that cranberry juice may improve augmentation index in overweight men, Couillard, C., Lamarche, B., Lemieux, S., Couture, P., Pomerleau, S., Lapointe, A., Ruel, G., Nutrition Research, 2013, 10.1016/j.nutres.2012.11.002
Randomized controlled study of the effect of a butter naturally enriched in trans fatty acids on blood lipids in healthy women, Lamarche, B., Couture, P., Chouinard, P.Y., Paquin, P., Lebeuf, Y., Baril-Gravel, L., Cyr, A., Charest, A., Lacroix, É., American Journal of Clinical Nutrition, 2012, 10.3945/ajcn.111.023408
Polymorphisms in FFAR4 (GPR120) gene modulate insulin levels and sensitivity after fish oil supplementation, Vohl, M.-C., Couture, P., Lemieux, S., Rudkowska, I., Cormier, H., Marcotte, B.V., Journal of Personalized Medicine, 2017, 10.3390/jpm7040015
Favourable impact of low-calorie cranberry juice consumption on plasma HDL-cholesterol concentrations in men, Couillard, C., Lamarche, B., Lemieux, S., Couture, P., Pomerleau, S., Ruel, G., British Journal of Nutrition, 2006, 10.1079/BJN20061814
Recommended dairy product intake modulates circulating fatty acid profile in healthy adults: A multi-centre cross-over study, Lamarche, B., Jones, P.J.H., Couture, P., Labonté, M.-È., Lépine, M.-C., Cyr, A., Abdullah, M.M.H., British Journal of Nutrition, 2015, 10.1017/S0007114514003894
LDL particle number and size and cardiovascular risk: Anything new under the sun?, Lamarche, B., Couture, P., Vors, C., Allaire, J., Current Opinion in Lipidology, 2017, 10.1097/MOL.0000000000000419
Clinical significance and treatment of hypertriglyceridemia, Gilbert, N., Couture, P., Geriatrics and Aging, 2006
Impact of milk consumption on cardiometabolic risk in postmenopausal women with abdominal obesity, Lamarche, B., Couture, P., Lemieux, S., Dodin, S., Grenier, G., Charest, A., Desroches, S., Labonté, M.-È., Gagnon, J., Drouin-Chartier, J.-P., Nutrition Journal, 2015, 10.1186/1475-2891-14-12

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Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2020/07

Louis-Charles Desjardins - Doctorat - En cours
Clémence Desjardins - Doctorat - En cours

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Direction de recherche dans les domaines suivants :

Biologie cellulaire et moléculaire
Médecine moléculaire
Sciences cliniques et biomédicales

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.

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