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Mohamed Chahine
Professeur titulaire

Contribution à la recherche
Axe de recherche de l'Université Laval :
Santé et bien-être durables
Thématiques de recherche de la Faculté de médecine :
Médecine régénératrice et moléculaire
Neurosciences et santé mentale
Transfert des connaissances
Santé des populations et pratiques optimales en santé
Domaines et intérêts de recherche du (de la) professeur(e) :
Génétique humaine
- Maladies génétiques
- Génétique moléculaire
- Mutation (processus)
- Thérapie génique
Neurosciences, santé mentale et toxicomanies
- Maladies neuromusculaires
- Récepteurs et transporteurs
- Signalisation cellulaire
- Maladies neurologiques
Santé circulatoire et respiratoire
- Cardiopathies congénitales
- Maladies cardiovasculaires
- Cellules souches et organogénèse
- Arythmies
Projets de recherche
- Mechanisms of heart rhythm disorders and therapeutic interventions in myotonic dystrophy type 1 - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2021-04-01 au 2026-03-31
- Cardiac Manifestations in Myotonic Dystrophy Type1: Arrhythmia Mechanisms and Novel Therapeutic Approaches - Department of Defense (USA) - Peer Reviewed Medical Research Program (PRMRP), chercheur principal - 2021-07-01 au 2025-06-30
- Apis mellifera ion channels and tools to study agroecosystems contaminants - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC), Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2020-04-01 au 2025-03-31
- Characterization of honeybee inward rectifier potassium (Kir) channels and their sensitivity to insecticides - Conseil de recherches en sciences naturelles et génie Canada - Subventions Alliance - Internationale - Catalyseur, chercheur principal - 2022-10-01 au 2023-09-30
- Human iPSC-derived neurons as a model of congenital myotonic dystrophy type 1 - Association canadienne de la dystrophie musculaire (L'), chercheur principal - 2021-05-01 au 2023-04-30
- Omega currents cause cardiac arrhythmias and dilated cardiomyopathy - AFM Téléthon, chercheur principal - 2020-09-01 au 2022-08-31
- Investigating the role of gating pore current in cardiac arrhythmias associated with dilated cardiomyopathy - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2017-04-01 au 2022-03-31
- Channelopathy 2021 - Fonds de recherche du Québec - Santé - Soutien à l'organisation de congrès internationaux du Cercle des Ambassadeurs de Québec et des Fonds de recherche du Québec, chercheur principal - 2021-01-01 au 2021-12-31
Publications
- Generation of four myotonic dystrophy type 1 patient iPSC lines (CBRCULi002-A, CBRCULi003-A, CBRCULi004-A, CBRCULi005-A) and a control (CBRCULi001-A) derived from lymphoblastoids cell lines, Dominic Jauvin, Marion Pierre, Mohamed Boutjdir, Jack Puymirat, Mohamed Chahine, Stem Cell Research, 2023, 10.1016/j.scr.2023.103037
- Antisense oligonucleotides as a potential treatment for brain deficits observed in myotonic dystrophy type 1, Siham Ait Benichou, Dominic Jauvin, Thiéry De Serres-Bérard, Marion Pierre, Karen K. Ling, C. Frank Bennett, Frank Rigo, Genevieve Gourdon, Mohamed Chahine, Jack Puymirat, Gene Therapy, 2022, 10.1038/s41434-022-00316-7
- Recent Progress and Challenges in the Development of Antisense Therapies for Myotonic Dystrophy Type 1, Thiéry De Serres-Bérard, Siham Ait Benichou, Dominic Jauvin, Mohamed Boutjdir, Jack Puymirat, Mohamed Chahine, International Journal of Molecular Sciences, 2022, 10.3390/ijms232113359
- Enhanced Delivery of Ligand-Conjugated Antisense Oligonucleotides (C16-HA-ASO) Targeting Dystrophia Myotonica Protein Kinase Transcripts for the Treatment of Myotonic Dystrophy Type 1, Siham Ait Benichou, Dominic Jauvin, Thiéry De Serres-Bérard, Frank Bennett, Frank Rigo, Genevieve Gourdon, Mohamed Boutjdir, Mohamed Chahine, Jack Puymirat, Human Gene Therapy, 2022, 10.1089/hum.2022.069
- SCN2A-related epilepsy of infancy with migrating focal seizures: report of a variant with apparent gain- and loss-of-function effects, Xiao-Ru Yang, Vamsi Krishna Murthy Ginjupalli, Olivier Theriault, Hugo Poulin, Juan Pablo Appendino, Ping Yee Billie Au, Mohamed Chahine, Journal of Neurophysiology, 2022, 10.1152/jn.00309.2021
- Racial Disparities in Ion Channelopathies and Inherited Cardiovascular Diseases Associated With Sudden Cardiac Death, Mohamed Chahine, John M. Fontaine, Mohamed Boutjdir, Journal of the American Heart Association, 2022, 10.1161/JAHA.121.023446
- NPRL2 Inhibition of mTORC1 Controls Sodium Channel Expression and Brain Amino Acid Homeostasis, Jeremy B. Hui, Jose Cesar Hernandez Silva, Mari Carmen Pelaez, Myriam Sévigny, Janani Priya Venkatasubramani, Quentin Plumereau, Mohamed Chahine, Christophe D. Proulx, Chantelle F. Sephton, Paul A. Dutchak, eneuro, 2022, 10.1523/ENEURO.0317-21.2022
- R1617Q epilepsy mutation slows Na V 1.6 sodium channel inactivation and increases the persistent current and neuronal firing, Hugo Poulin, Mohamed Chahine, The Journal of Physiology, 2021, 10.1113/JP280838
- Novel re-expression of L-type calcium channel Cav1.3 in left ventricles of failing human heart, Ujala Srivastava, Rachael Jennings-Charles, Yongxia S. Qu, Samuel Sossalla, Mohamed Chahine, Mohamed Boutjdir, Heart Rhythm, 2020, 10.1016/j.hrthm.2020.02.025
- Differentiation of lymphoblastoid-derived iPSCs into functional cardiomyocytes, neurons and myoblasts, Hugo Poulin, Laurie Martineau, Véronique Racine, Jack Puymirat, Mohamed Chahine, Biochemical and Biophysical Research Communications, 2019, 10.1016/j.bbrc.2019.05.176
- Voltage-gated sodium channels from the bees Apis mellifera and Bombus terrestris are differentially modulated by pyrethroid insecticides, Aklesso Kadala, Mercédès Charreton, Pierre Charnet, Thierry Cens, Mathieu Rousset, Mohamed Chahine, Bernard E. Vaissière, Claude Collet, Scientific Reports, 2019, 10.1038/s41598-018-37278-z
- A204E mutation in Nav1.4 DIS3 exerts gain- and loss-of-function effects that lead to periodic paralysis combining hyper- with hypo-kalaemic signs, Yosuke Kokunai, Carine Dalle, Savine Vicart, Damien Sternberg, Valérie Pouliot, Said Bendahhou, Emmanuel Fournier, Mohamed Chahine, Bertrand Fontaine, Sophie Nicole, Scientific Reports, 2018, 10.1038/s41598-018-34750-8
- A leaky voltage sensor domain of cardiac sodium channels causes arrhythmias associated with dilated cardiomyopathy, Adrien Moreau, Pascal Gosselin-Badaroudine, Aurélie Mercier, Bettina Burger, Dagmar I. Keller, Mohamed Chahine, Scientific Reports, 2018, 10.1038/s41598-018-31772-0
- Improving the characterization of calcium channel gating pore currents with Stac3, Mohamed Chahine, Journal of General Physiology, 2018, 10.1085/jgp.201711984
- Substitutions of the S4DIV R2 residue (R1451) in NaV1.4 lead to complex forms of paramyotonia congenita and periodic paralyses, Hugo Poulin, Pascal Gosselin-Badaroudine, Savine Vicart, Karima Habbout, Damien Sternberg, Serena Giuliano, Bertrand Fontaine, Saïd Bendahhou, Sophie Nicole, Mohamed Chahine, Scientific Reports, 2018, 10.1038/s41598-018-20468-0
- Biophysical, Molecular, and Pharmacological Characterization of Voltage-Dependent Sodium Channels From Induced Pluripotent Stem Cell-Derived Cardiomyocytes, Adrien Moreau, Aurélie Mercier, Olivier Thériault, Mohamed Boutjdir, Bettina Burger, Dagmar I. Keller, Mohamed Chahine, Canadian Journal of Cardiology, 2017, 10.1016/j.cjca.2016.10.001
- Biophysical characterization of the honeybee DSC1 orthologue reveals a novel voltage-dependent Ca2+ channel subfamily: CaV4, Pascal Gosselin-Badaroudine, Adrien Moreau, Louis Simard, Thierry Cens, Matthieu Rousset, Claude Collet, Pierre Charnet, Mohamed Chahine, Journal of General Physiology, 2016, 10.1085/jgp.201611614
- Modulation of peripheral Na+ channels and neuronal firing by n-butyl-p-aminobenzoate, , European Journal of Pharmacology, 2014, 10.1016/j.ejphar.2014.01.036
Contribution à l'enseignement aux cycles supérieurs
Étudiant(e)s dirigé(e)s*
Depuis 2009- Charlotte Souil - Doctorat - En cours
- Quentin Plumereau - Doctorat - En cours
- Charles-Albert Chapotte-Baldacci - Post-doctorat - En cours
- Thiéry De Serres-Bérard - Doctorat - En cours
- Vamsi Krishna Murthy Ginjupalli - Doctorat - En cours
- Pascal Gosselin-Badaroudine - Maîtrise avec mémoire - 2012/05
- Adrien Moreau - Doctorat - 2015/09
- Aude Popek - Maîtrise avec mémoire - 2018/01
- Mohammed Djemai - Maîtrise avec mémoire - 2020/09
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