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Mohamed Chahine

Professeur titulaire

Mohamed Chahine
Mohamed.Chahine@phc.ulaval.ca
Centre thématique de recherche en neurosciences
Centre de recherche CERVO
Groupe de recherche en écologie buccale
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Contribution à la recherche

Thématiques de recherche de la Faculté de médecine

  • Médecine régénératrice et médecine moléculaire
  • Neurosciences et santé mentale
  • Transfert des connaissances
  • Santé des populations et pratiques optimales en santé

Projets de recherche en cours

  • Canada Research Chair in Neuromuscular Disorders and Channelopathies - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2024-10-01 au 2031-09-30
  • New mechanisms linking voltage-gated sodium channels to structural heart disease - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2025-04-01 au 2030-03-31
  • Neurotoxicités-induites par la chimitothérapie: Approches pré-clinique, clinique et génétique - Fonds de recherche du Québec - Nature et technologies - Programme Samuel-De Champlain, co-chercheur - 2025-04-01 au 2027-03-31
  • Mechanisms of heart rhythm disorders and therapeutic interventions in myotonic dystrophy type 1 - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2021-04-01 au 2026-03-31
  • Cardiac Manifestations in Myotonic Dystrophy Type1: Arrhythmia Mechanisms and Novel Therapeutic Approaches - Department of Defense (USA) - Peer Reviewed Medical Research Program (PRMRP), chercheur principal - 2021-07-01 au 2025-06-30

Financements des 2 dernières années

  • Apis mellifera ion channels and tools to study agroecosystems contaminants - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC), Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2020-04-01 au 2025-03-31
  • Ant venom peptides as potential inhibitors for peripheral nerve sodium channels - Conseil de recherches en sciences naturelles et génie Canada - Subventions Alliance - Internationale - Catalyseur, chercheur principal - 2023-12-27 au 2024-12-26
  • Characterization of honeybee inward rectifier potassium (Kir) channels and their sensitivity to insecticides - Conseil de recherches en sciences naturelles et génie Canada - Subventions Alliance - Internationale - Catalyseur, chercheur principal - 2022-10-01 au 2023-09-30
  • Omega currents cause cardiac arrhythmias and dilated cardiomyopathy - AFM Téléthon, chercheur principal - 2020-09-01 au 2022-08-31

Publications

  • Generation of induced pluripotent stem cell lines from pediatric patients with congenital myotonic dystrophy (CBRCULi012-A and CBRCULi013-A) and age-matched controls (CBRCULi010-A and CBRCULi011-A), Mohamed Chahine, Jack Puymirat, Dominic Jauvin, Thiéry De Serres-Bérard, Stem Cell Research, 2023, 10.1016/j.scr.2023.103234
  • Voltage-gated sodium channels from the bees Apis mellifera and Bombus terrestris are differentially modulated by pyrethroid insecticides, Claude Collet, Bernard E. Vaissière, Mohamed Chahine, Mathieu Rousset, Thierry Cens, Pierre Charnet, Mercédès Charreton, Aklesso Kadala, Scientific Reports, 2019, 10.1038/s41598-018-37278-z
  • Enhanced Delivery of Ligand-Conjugated Antisense Oligonucleotides (C16-HA-ASO) Targeting Dystrophia Myotonica Protein Kinase Transcripts for the Treatment of Myotonic Dystrophy Type 1, Jack Puymirat, Mohamed Chahine, Mohamed Boutjdir, Genevieve Gourdon, Frank Rigo, Frank Bennett, Thiéry De Serres-Bérard, Dominic Jauvin, Siham Ait Benichou, Human Gene Therapy, 2022, 10.1089/hum.2022.069
  • Optical Mapping of Cardiomyocytes in Monolayer Derived from Induced Pluripotent Stem Cells, Mohamed Chahine, Mohamed Boutjdir, Michael Cupelli, Mohammed Djemai, Cells, 2023, 10.3390/cells12172168
  • Differentiation of lymphoblastoid-derived iPSCs into functional cardiomyocytes, neurons and myoblasts, Mohamed Chahine, Jack Puymirat, Véronique Racine, Laurie Martineau, Hugo Poulin, Biochemical and Biophysical Research Communications, 2019, 10.1016/j.bbrc.2019.05.176
  • Modulation of peripheral Na+ channels and neuronal firing by n-butyl-p-aminobenzoate, , European Journal of Pharmacology, 2014, 10.1016/j.ejphar.2014.01.036
  • A204E mutation in Nav1.4 DIS3 exerts gain- and loss-of-function effects that lead to periodic paralysis combining hyper- with hypo-kalaemic signs, Sophie Nicole, Bertrand Fontaine, Mohamed Chahine, Emmanuel Fournier, Said Bendahhou, Valérie Pouliot, Damien Sternberg, Savine Vicart, Carine Dalle, Yosuke Kokunai, Scientific Reports, 2018, 10.1038/s41598-018-34750-8
  • SCN2A-related epilepsy of infancy with migrating focal seizures: report of a variant with apparent gain- and loss-of-function effects, Mohamed Chahine, Ping Yee Billie Au, Juan Pablo Appendino, Hugo Poulin, Olivier Theriault, Vamsi Krishna Murthy Ginjupalli, Xiao-Ru Yang, Journal of Neurophysiology, 2022, 10.1152/jn.00309.2021
  • A leaky voltage sensor domain of cardiac sodium channels causes arrhythmias associated with dilated cardiomyopathy, Mohamed Chahine, Dagmar I. Keller, Bettina Burger, Aurélie Mercier, Pascal Gosselin-Badaroudine, Adrien Moreau, Scientific Reports, 2018, 10.1038/s41598-018-31772-0
  • Arrhythmias and Ion Channelopathies Causing Sudden Cardiac Death in Hispanic/Latino and Indigenous Populations, Mohamed Chahine, Sahil Zaveri, Mohamed Boutjdir, 2024, 10.22541/au.171300659.94084184/v1
  • Biophysical characterization of the honeybee DSC1 orthologue reveals a novel voltage-dependent Ca2+ channel subfamily: CaV4, Mohamed Chahine, Pierre Charnet, Claude Collet, Matthieu Rousset, Thierry Cens, Louis Simard, Adrien Moreau, Pascal Gosselin-Badaroudine, Journal of General Physiology, 2016, 10.1085/jgp.201611614
  • Generation of a lymphoblastoid-derived induced pluripotent stem cell line (CBRCULi015-A) from a patient with congenital myotonic dystrophy, Mohamed Chahine, Jack Puymirat, Valérie Pouliot, Dominic Jauvin, Thiéry De Serres-Bérard, Stem Cell Research, 2024, 10.1016/j.scr.2024.103430
  • Substitutions of the S4DIV R2 residue (R1451) in NaV1.4 lead to complex forms of paramyotonia congenita and periodic paralyses, Mohamed Chahine, Sophie Nicole, Saïd Bendahhou, Bertrand Fontaine, Serena Giuliano, Damien Sternberg, Karima Habbout, Savine Vicart, Pascal Gosselin-Badaroudine, Hugo Poulin, Scientific Reports, 2018, 10.1038/s41598-018-20468-0
  • NPRL2 Inhibition of mTORC1 Controls Sodium Channel Expression and Brain Amino Acid Homeostasis, Paul A. Dutchak, Chantelle F. Sephton, Christophe D. Proulx, Mohamed Chahine, Quentin Plumereau, Janani Priya Venkatasubramani, Myriam Sévigny, Mari Carmen Pelaez, Jose Cesar Hernandez Silva, Jeremy B. Hui, eneuro, 2022, 10.1523/ENEURO.0317-21.2022
  • Biophysical, Molecular, and Pharmacological Characterization of Voltage-Dependent Sodium Channels From Induced Pluripotent Stem Cell-Derived Cardiomyocytes, Mohamed Chahine, Dagmar I. Keller, Bettina Burger, Mohamed Boutjdir, Olivier Thériault, Aurélie Mercier, Adrien Moreau, Canadian Journal of Cardiology, 2017, 10.1016/j.cjca.2016.10.001
  • Racial Disparities in Ion Channelopathies and Inherited Cardiovascular Diseases Associated With Sudden Cardiac Death, Mohamed Boutjdir, John M. Fontaine, Mohamed Chahine, Journal of the American Heart Association, 2022, 10.1161/JAHA.121.023446
  • Generation of four myotonic dystrophy type 1 patient iPSC lines (CBRCULi002-A, CBRCULi003-A, CBRCULi004-A, CBRCULi005-A) and a control (CBRCULi001-A) derived from lymphoblastoids cell lines, Mohamed Chahine, Jack Puymirat, Mohamed Boutjdir, Marion Pierre, Dominic Jauvin, Stem Cell Research, 2023, 10.1016/j.scr.2023.103037
  • Lymphoblastoid cell lines derived from iPSCs of a myotonic dystrophy type 1 patient carrying 700 CTG repeats (CBRCULi007-A) and a control (CBRCULi006-A), Mohamed Boutjdir, Jack Puymirat, Marion Pierre, Dominic Jauvin, Mohamed Chahine, Stem Cell Research, 2023, 10.1016/j.scr.2023.103148
  • Improving the characterization of calcium channel gating pore currents with Stac3, Mohamed Chahine, Journal of General Physiology, 2018, 10.1085/jgp.201711984
  • R1617Q epilepsy mutation slows NaV1.6 sodium channel inactivation and increases the persistent current and neuronal firing, Mohamed Chahine, Hugo Poulin, The Journal of Physiology, 2021, 10.1113/JP280838
  • Exploring SCN5A variants associated with atrial fibrillation in atrial cardiomyocytes derived from human induced pluripotent stem cells: A characterization study, Mohamed Chahine, Michael H. Gollob, Hugo Poulin, Valérie Pouliot, Mohammed Djemai, Marion Pierre, Heart Rhythm, 2024, 10.1016/j.hrthm.2024.09.013
  • Impacts of DCM-linked gating pore currents on the electrophysiological characteristics of hiPSC-CM monolayers, Mohamed Chahine, Maroua Jalouli, Mohammed Djemai, Biochemical and Biophysical Research Communications, 2024, 10.1016/j.bbrc.2024.150175
  • Generation of a patient-specific iPSC cell line with cardiac arrhythmias and dilated cardiomyopathy (CBRCULi016-A), an isogenic control (CBRCULi016-A-1), and a paternal control (CBRCULi017-A), Mohamed Chahine, Charles-Albert Chapotte-Baldacci, Hugo Poulin, Dominic Jauvin, Mohammed Djemai, Stem Cell Research, 2024, 10.1016/j.scr.2024.103308
  • Recent Progress and Challenges in the Development of Antisense Therapies for Myotonic Dystrophy Type 1, Mohamed Chahine, Jack Puymirat, Mohamed Boutjdir, Dominic Jauvin, Siham Ait Benichou, Thiéry De Serres-Bérard, International Journal of Molecular Sciences, 2022, 10.3390/ijms232113359
  • Generation of a control induced pluripotent stem cell line (CBRCULi014-A) derived from the lymphoblastoid cells of a pediatric individual, Mohamed Chahine, Jack Puymirat, Valérie Pouliot, Thiéry De Serres-Bérard, Stem Cell Research, 2024, 10.1016/j.scr.2024.103587
  • Antisense oligonucleotides as a potential treatment for brain deficits observed in myotonic dystrophy type 1, Jack Puymirat, Mohamed Chahine, Genevieve Gourdon, Frank Rigo, C. Frank Bennett, Karen K. Ling, Marion Pierre, Thiéry De Serres-Bérard, Dominic Jauvin, Siham Ait Benichou, Gene Therapy, 2022, 10.1038/s41434-022-00316-7
  • Arrhythmias and ion channelopathies causing sudden cardiac death in Hispanic/Latino and Indigenous populations, Mohamed Boutjdir, Mohamed Chahine, Sahil Zaveri, Journal of Cardiovascular Electrophysiology, 2024, 10.1111/jce.16282
  • Novel re-expression of L-type calcium channel Cav1.3 in left ventricles of failing human heart, Mohamed Boutjdir, Mohamed Chahine, Samuel Sossalla, Yongxia S. Qu, Rachael Jennings-Charles, Ujala Srivastava, Heart Rhythm, 2020, 10.1016/j.hrthm.2020.02.025

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2020/05
  • Quentin Plumereau - Doctorat - En cours
  • Fabien Sourisseau - Doctorat - En cours
  • Mohammed Djemai - Doctorat - En cours
  • Vamsi Krishna Murthy Ginjupalli - Doctorat - En cours
  • Cyrielle Jajkiewicz - Post-doctorat - En cours
  • Charles-Albert Chapotte-Baldacci - Post-doctorat - En cours
  • Thiéry De Serres-Bérard - Doctorat - 2025/01

Encadrement d'étudiant(e)s

Direction de recherche dans les domaines suivants :

  • Biologie cellulaire et moléculaire
  • Neurobiologie — Neurosciences
  • Sciences cliniques et biomédicales

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Disponibilité d'encadrement d'étudiant(e)s

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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