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Manuel Caruso

Professeur titulaire

Manuel Caruso
Centre de recherche sur le cancer
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Médecine régénératrice et médecine moléculaire
Oncologie

Domaines et intérêts de recherche du (de la) professeur(e) :

Cancer
  • Thérapie génique du cancer
Génétique humaine
  • Thérapie génique

Projets de recherche

  • Développement de greffons d’épiderme autologue en combinant thérapie génique et génie tissulaire pour traiter l’épidermolyse bulleuse jonctionnelle - Fondation du Grand défi Pierre Lavoie, Fondation Courtois, co-chercheur - 2024-04-01 au 2025-03-31
  • Projets structurants ThéCell 2023-2024_Greffons d’épiderme autologue en combinant thérapie génique et génie tissulaire pour traiter l’épidermolyse bulleuse jonctionnelle - Fonds de recherche du Québec - Santé - Réseaux thématiques de recherche, co-chercheur - 2023-04-01 au 2024-03-31
  • Combining tissue-engineered skin with ex vivo gene therapy correction to develop a treatment for epidermolysis bullosa - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Réseau de centres d'excellence (RCE), co-chercheur - 2022-04-01 au 2024-03-31
  • Towards an epidermolysis bullosa clinical trial with tissue-engineered skin after ex vivo gene therapy correction - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC), Fondation du CHU de Québec, Fonds de recherche du Québec - Santé - Réseau de centres d'excellence (RCE), co-chercheur - 2020-08-01 au 2022-02-28

Publications

  • 818. Development of Packaging Cell Lines for the Large-Scale Production of High-Titer Clinical Grade Recombinant Retroviruses, Manuel Caruso, Karim Ghani, Molecular Therapy, 2006, 10.1016/j.ymthe.2006.08.903
  • PG13 packaging cells produce recombinant retroviruses carrying a diphtheria toxin mutant which kills cancer cells., Caruso, M., Qiao, J., Journal of Virology, 2002
  • Can Diphtheria Toxin be used for Gene Therapy of Human Immunodeficiency Virus Infection?, Klatzmann, D., Alizon, M., Roussel, M., Tsikas, G., Caruso, M., AIDS Research and Human Retroviruses, 1992, 10.1089/aid.1992.8.1949
  • Bystander effect in glioblastoma cells with a predominant cytoplasmic localization of connexin43, Caruso, M., Ghani, K., Cottin, S., Cancer Gene Therapy, 2008, 10.1038/cgt.2008.49
  • A nuclear localization signal in the matrix of spleen necrosis virus (SNV) does not allow efficient gene transfer into quiescent cells with SNV-derived vectors, Caruso, M., Caron, M.-C., Virology, 2005, 10.1016/j.virol.2005.05.024
  • Selective killing of CD4+ cells harboring a human immunodeficiency virus-inducible suicide gene prevents viral spread in an infected cell population, Klatzmann, D., Caruso, M., Proceedings of the National Academy of Sciences of the United States of America, 1992
  • Direct evidence for the absence of intercellular trafficking of VP22 fused to GFP or to the herpes simplex virus thymidine kinase, Caruso, M., de Campos-Lima, P., Qiao, J., Roy, V., Gene Therapy, 2005, 10.1038/sj.gt.3302394
  • VSV-G pseudotyped, MuLV-based, semi-replication-competent retrovirus for cancer treatment, Vile, R.G., Diaz, R.M., Caruso, M., Thompson, J., Kottke, T., Sanchez-Perez, L., Moreno, J., Qiao, J., Gene Therapy, 2006, 10.1038/sj.gt.3302782
  • A stable platform for the production of virus-like particles pseudotyped with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike protein, Manuel Caruso, Pedro O. de Campos-Lima, Karim Ghani, Sylvie Roy, Virus Research, 2021, 10.1016/j.virusres.2021.198305
  • Generation of High-Titer Self-Inactivated γ-Retroviral Vector Producer Cells, , Molecular Therapy - Methods & Clinical Development, 2019, 10.1016/j.omtm.2019.05.013
  • RD114-pseudotyped retroviral vectors kill cancer cells by syncytium formation and enhance the cytotoxic effect of the TK/GCV gene therapy strategy, Caruso, M., de Campos Lima, P.O., Qiao, J., Roullin, V.-G., Germain, E., Journal of Gene Medicine, 2005, 10.1002/jgm.691
  • Variable efficiency of the thymidine kinase/ganciclovir system in human glioblastoma cell lines: Implications for gene therapy, Snodgrass, H.R., Platika, D., Sanson, M., Caruso, M., Chen, X., Shulok, J., Waddell, K., Sturtz, F.G., Human Gene Therapy, 1997
  • Efficient human hematopoietic cell transduction using RD114- and GALV-pseudotyped retroviral vectors produced in suspension and serum-free media, Caruso, M., Rivière, I., Kamen, A., Olszewska, M., De Campos-Lima, P.O., Wang, X., Ghani, K., Human Gene Therapy, 2009, 10.1089/hum.2009.001
  • Expression of a Tat-inducible herpes simplex virus-thymidine kinase gene protectsacyclovir-treated CD4 cells from HIV-1 spread by conditional suicide and inhibition of reverse transcription, Klatzmann, D., Lowy, I., Clavel, F., Brisson, E., Zhang, S., Salomon, B., Caruso, M., Virology, 1995, 10.1016/S0042-6822(95)80065-4
  • Retrovirus-mediated gene transfer of the human multidrug resistance-associated protein into hematopoietic cells protects mice from chemotherapy-induced leukopenia, D'Hondt, V., Symann, M., Bank, A., Caruso, M., Deeley, R., Cole, S., Goeminne, J.-C., Lenoir, E., Feyens, A.-M., Bayat, B., Guillaume, T., Govaerts, A.-S., Machiels, J.-P., Human Gene Therapy, 1999, 10.1089/10430349950018553
  • Genetic pharmacomodulation of nucleoside analogues and gene therapy for AIDS and cancer., Klatzmann, D., Caruso, M., Loubière, L., Guettari, N., Antibiotics and chemotherapy, 1996
  • A new modified amino acid: 2-amino-3-mercapto-3-phenylpropionic acid (3-mercaptophenylalanine). Synthesis of derivatives, separation of stereoisomers, and assignment of absolute configuration, Marquet, A., Chassaing, G., Caruso, M., Ploux, O., Journal of Organic Chemistry, 1988
  • Treatment of experimental liver tumors by in vivo suicide gene transfer in rats | TRAITEMENT DE TUMEURS HEPATIQUES EXPERIMENTALES PAR TRANSFERT DE GENE SUICIDE IN VIVO CHEZ LE RAT, Klatzmann, D., Salzmann, J.-L., Khayat, D., Andreoletti, M., Houssin, D., Caruso, M., Panis, Y., Comptes Rendus de l'Academie des Sciences - Series III, 1992
  • Enhanced ganciclovir killing and bystander effect of human tumor cells transduced with a retroviral vector carrying a herpes simplex virus thymidine kinase gene mutant, Caruso, M., Black, M.E., Qiao, J., Human Gene Therapy, 2000, 10.1089/10430340050083298
  • Efficient production of Moloney murine leukemia virus-like particles pseudotyped with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike protein, Manuel Caruso, Pedro O. de Campos-Lima, Karim Ghani, Sylvie Roy, 2020, 10.1101/2020.09.16.298992
  • Gemcitabine intercellular diffusion mediated by gap junctions: new implications for cancer therapy, Manuel Caruso, Pedro de Campos-Lima, Karim Ghani, Sylvine Cottin, Molecular Cancer, 2010, 10.1186/1476-4598-9-141
  • Nucleoside analogue metabolism by herpes simplex virus type I thymidine kinase and gene therapy for cancer and AIDS, Klatzmann, D., Caruso, M., Guettari, N., Loubiere, L., International Antiviral News, 1995
  • Peel Test to Assess the Adhesion Strength of the Dermal-Epidermal Junction in Tissue-Engineered Skin., , Tissue engineering. Part C, Methods, 2020, 10.1089/ten.tec.2019.0268
  • Efficient retroviral gene transfer of a Tat-regulated herpes simplex virus thymidine kinase gene for HIV gene therapy, Bank, A., Caruso, M., Virus Research, 1997, 10.1016/S0168-1702(97)00124-X
  • Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma, Chen, S.-H., Woo, S.L.C., Finegold, M., Kosai, K.-I., Kwong, Y.-L., Xu, B., Pham-Nguyen, K., Caruso, M., Proceedings of the National Academy of Sciences of the United States of America, 1996, 10.1073/pnas.93.21.11302
  • Strategies integrating gene therapy and tissue engineering into the development of treatments for recessive dystrophic epidermolysis bullosa, Germain, L., Caruso, M., Ghani, K., Bisson, F., Larouche, D., Piaceski, A.D., Epidermolysis Bullosa (EB): Prevalence, Clinical Manifestations and Management, 2016
  • A Dominant-Negative Approach That Prevents Diphthamide Formation Confers Resistance to Pseudomonas Exotoxin A and Diphtheria Toxin, Manuel Caruso, Karim Ghani, Vincent Roy, PLoS ONE, 2010, 10.1371/journal.pone.0015753
  • The size of the unbranched aliphatic chain determines the immunomodulatory potency of short and long chain n-Alkanols, De Campos-Lima, P.O., Caruso, M., Ghani, K., Désy, O., Carignan, D., Journal of Biological Chemistry, 2013, 10.1074/jbc.M113.466334
  • High translation efficiency is mediated by the encephalomyocarditis virus internal ribosomal entry sites if the natural sequence surrounding the eleventh AUG is retained, Caruso, M., Girard, M.H., Roy, V., Qiao, J., Human Gene Therapy, 2002, 10.1089/10430340252899046
  • Human immunodeficiency virus type 1 (HIV-1) infection of herpesvirus saimiri-immortalized human CD4-positive T lymphoblastoid cells: Evidence of enhanced HIV-1 replication and cytopathic effects caused by endogenous interferon-γ, Volsky, D.J., Caruso, M., Saha, K., Virology, 1997, 10.1006/viro.1997.8485
  • Diphtheria toxin mutant CRM197 is an inhibitor of protein synthesis that induces cellular toxicity, Manuel Caruso, Karim Ghani, Jian Qiao, Toxicon, 2008, 10.1016/j.toxicon.2007.09.010
  • Nilotinib and imatinib inhibit cytarabine cellular uptake: Implications for combination therapy, Manuel Caruso, Pedro O. de Campos-Lima, Karim Ghani, Josy S. Naud, Leukemia Research, 2012, 10.1016/j.leukres.2012.06.012
  • Regression of established macroscopic liver metastases after in situ transduction of a suicide gene, Klatzmann, D., Salzmann, J.-L., Houssin, D., Gagandeep, S., Panis, Y., Caruso, M., Proceedings of the National Academy of Sciences of the United States of America, 1993
  • HIV-triggered killing of booby trapped cells prevents viral spread in an HIV-infected cell population, Klatzmann, D., Alizon, M., Roussel, M., Tzikas, G., Caruso, M., Bone Marrow Transplantation, 1992
  • Immunosuppressive effect of isopropanol: Down-regulation of cytokine production results from the alteration of discrete transcriptional pathways in activated lymphocytes, De Campos-Lima, P.O., Caruso, M., Carignan, D., Désy, O., Journal of Immunology, 2008
  • Methanol Induces a Discrete Transcriptional Dysregulation that Leads to Cytokine Overproduction in Activated Lymphocytes, Pedro O. de Campos-Lima, Manuel Caruso, Damien Carignan, Olivier Désy, Toxicological Sciences, 2010, 10.1093/toxsci/kfq212
  • Gap junctions in human glioblastomas: Implications for suicide gene therapy, Caruso, M., Cantin, L., Gould, P.V., Cottin, S., Cancer Gene Therapy, 2011, 10.1038/cgt.2011.38
  • Genetically controlled pharmacomodulation for HIV gene therapy | PHARMACOMODULATION CONTROLEE GENETIQUEMENT: APPLICATION AU TRAITEMENT DE L'INFECTION PAR LE VIH, Klatzmann, D., Caruso, M., Comptes Rendus de l'Academie des Sciences - Serie III, 1994
  • Rescue of the immunotherapeutic potential of a novel T cell epitope in the Epstein-Barr virus latent membrane protein 2, de Campos-Lima, P.O., Caruso, M., Avila-Cariño, J., Lalonde, A., Virology, 2007, 10.1016/j.virol.2006.10.013
  • Generation of a high-titer packaging cell line for the production of retroviral vectors in suspension and serum-free media, Caruso, M., Kamen, A., Cottin, S., Ghani, K., Gene Therapy, 2007, 10.1038/sj.gt.3303039
  • Cellular Thymidine Kinase Activity Is Required for the Inhibition of HIV-1 Replication by AZT in Lymphocytes, David Klatzmann, Stephen P. Goff, Manuel Caruso, Israel Lowy, Virology, 1994, 10.1006/viro.1994.1185
  • Characterization of an alternative packaging system derived from the cat RD114 retrovirus for gene delivery, Caruso, M., Caron, M.-C., de Campos-Lima, P.O., Cottin, S., Ghani, K., Journal of Gene Medicine, 2009, 10.1002/jgm.1351
  • Translating the combination of gene therapy and tissue engineering for treating recessive dystrophic epidermolysis bullosa., , European cells & materials, 2018, 10.22203/ecm.v035a06
  • Gene therapy against cancer and HIV infection using the gene encoding herpes simplex virus thymidine kinase, Manuel Caruso, Molecular Medicine Today, 1996, 10.1016/1357-4310(96)88774-0
  • Retrovirus-mediated gene transfer of the multidrug resistance-associated protein (MRP) cDNA protects cells from chemotherapeutic agents, Bank, A., Caruso, M., D'Hondt, V., Human Gene Therapy, 1997
  • A truncated herpes simplex virus thymidine kinase phosphorylates thymidine and nucleoside analogs and does not cause sterility in transgenic mice, Klatzmann, D., Onclercq, R., Caruso, M., Loubiere, L., Maury, S., Salomon, B., Molecular and Cellular Biology, 1995

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Josy Baldaheani Naud - Maîtrise avec mémoire - 2013/01
  • Florence Pagé-Larivière - Maîtrise avec mémoire - 2013/05
  • Angela Dakiw Piaceski - Maîtrise avec mémoire - 2016/09
  • Michael Boivin-Welch - Maîtrise avec mémoire - 2019/01

Encadrement d'étudiant(e)s pour les programmes suivants :

*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.