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Madeleine Carreau

Professeure titulaire

Madeleine.Carreau@fmed.ulaval.ca

Département de pédiatrie

Centre de recherche du CHU de Québec - Université Laval

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Contribution à la recherche

Thématiques de recherche de la Faculté de médecine

Oncologie
Médecine régénératrice et médecine moléculaire
Reproduction, génétique, périnatalité et développement

Financements des 2 dernières années

To understand the molecular basis of carcinogenesis in FA. - Fanconi Anemia Research Fund, Inc., chercheur principal - 2020-12-01 au 2023-11-30

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Publications

Bone marrow failure in the fanconi anemia group C mouse model after DNA damage, Buchwald, M., Dick, J.E., McKerlie, C., Doedens, M., Liu, L., Gan, O.I., Carreau, M., Blood, 1998, 10.1182/blood.v91.8.2737.2737_2737_2744
Regulation of the Fanconi Anemia Group C Protein through Proteolytic Modification, Carreau, M., Lévesque, G., Buchwald, M., Khandjian, E.W., Huard, C., Godin, C., Delisle, M.-C., Charbonneau, C., Tremblay, C.S., Goulet, I., Brodeur, I., Journal of Biological Chemistry, 2004, 10.1074/jbc.M301291200
Loss of FancC function results in decreased hematopoietic stem cell repopulating ability, Clapp, D.W., Yoder, M.C., Buchwald, M., Carreau, M., Ramani, R., Gobbett, T.A., Haneline, L.S., Blood, 1999, 10.1182/blood.v94.1.1.413k03_1_8
The Fanconi anemia pathway has a dual function in Dickkopf-1 transcriptional repression, Carreau, M., Lévesque, G., Magron, A., Tremblay, C.S., Huard, C.C., Proceedings of the National Academy of Sciences of the United States of America, 2014, 10.1073/pnas.1314226111
The fanconi anemia core complex acts as a transcriptional co-regulator in hairy enhancer of split 1 signaling, Carreau, M., Lévesque, G., Bourdages, V., Habi, O., Huang, F.-F., Huard, C.C., Tremblay, C.S., Journal of Biological Chemistry, 2009, 10.1074/jbc.M807921200
Mitomycin C-induced DNA damage in Fanconi anemia: Cross-linking or redox-mediated effects? [7] (multiple letters), Buchwald, M., Carreau, M., Korkina, L.G., Zatterale, A., Pagano, G., Blood, 1999, 10.1182/blood.v93.3.1116
Functional Retroviral Vector for Gene Therapy of Xeroderma Pigmentosum Group D Patients, Sarasin, A., Mezzina, M., Heard, J.-M., Danos, O., Salvetti, A., Eveno, E., Quilliet, X., Carreau, M., Human Gene Therapy, 1995, 10.1089/hum.1995.6.10-1307
The Fanconi anemia C protein binds to and regulates stathmin-1 phosphorylation, Carreau, M., Elowe, S., Magron, A., PLoS ONE, 2015, 10.1371/journal.pone.0140612
Modulating Dickkopf-1: A strategy to monitor or treat cancer?, Carreau, M., Masi, D., Mazon, M., Cancers, 2016, 10.3390/cancers8070062
Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia, Buchwald, M., Joyner, A.L., Dick, J.E., Percy, D.H., Cross, J., Freedman, M.H., Guidos, C.J., Groves, T., Auerbach, A., Carreau, M., Gan, O., Liu, L., Youssoufian, H., McKerlie, C., Auerbach, W., Tomkins, D.J., Chen, M., Nature Genetics, 1996, 10.1038/ng0496-448
Drug sensitivity spectra in Fanconi anemia lymphoblastoid cell lines of defined complementation groups, Buchwald, M., Joenje, H., Bosnoyan-Collins, L., Alon, N., Carreau, M., Mutation Research - DNA Repair, 1999, 10.1016/S0921-8777(99)00041-5
The Fanconi anemia genes, Buchwald, M., Carreau, M., Current Opinion in Pediatrics, 1998, 10.1097/00008480-199802000-00013
Expression cloning of a cdna for the major fanconi anaemia gene, FAA, Joenje, H., Buchwald, M., Arwert, F., Pronk, J.C., Kruyt, F.A.E., Pals, G., Gille, J.J.P., Strunk, M.H.P., Van Berkel, C.C.M., Cheng, N.C., Savoia, A., Callen, D.F., Carreau, M., Lightfoot, J., Parker, L., Wijker, M., Alon, N., Bosnoyan-Collins, L., Rooimans, M.A., Ten Foe, J.R.L., Nature Genetics, 1996, 10.1038/ng1196-320
Development of a new easy complementation assay for DNA repair deficient human syndromes using cloned repair genes, Mezzina, M., Sarasin, A., Hoeijmakers, J.H.J., Vermeulen, W., Stefanini, M., Tanganelli, B., Benoit, A., Chevalier-lagente, O., Quilliet, X., Eveno, E., Carreau, M., Carcinogenesis, 1995, 10.1093/carcin/16.5.1003
Lack of self-renewal capacity in Fancc^-/- stem cells after ex vivo expansion, Carreau, M., Messier, N., Delisle, M.-C., Habi, O., Stem Cells, 2005, 10.1634/stemcells.2004-0356
Erratum: Expression cloning of a cDNA for the major Fanconi anaemia gene, FAA (Nature Genetics (1996) 14 (320-323)), Joenje, H., Buchwald, M., Arwert, F., Pronk, J.C., Kruyt, F.A.E., Pals, G., Gille, J.J.P., Strunk, M.H.P., Van Berkel, C.G.M., Cheng, N.C., Savoia, A., Callen, D.F., Carreau, M., Lightfoot, J., Parker, L., Wijker, M., Alon, N., Bosnoyan-Collins, L., Rooimans, M.A., Foe, J.R.L.T., Nature Genetics, 1996, 10.1038/ng1296-488b
Correction by the ercc2 gene of UV sensitivity and repair deficiency phenotype in a subset of trichothiodystrophy cells, Sarasin, A., A. Weber, C., Lehmann, A.R., Stefanini, M., Hoeijmakers, J.H.J., Vermeulen, W., Carreau, M., Benoit, A., Chevallier-lagente, O., Eveno, E., Mezzina, M., Carcinogenesis, 1994, 10.1093/carcin/15.8.1493
FANCC localizes with UNC5A at neurite outgrowth and promotes neuritogenesis, Carreau, M., Lévesque, G., Ben Aissa, M., Huang, F., BMC Research Notes, 2018, 10.1186/s13104-018-3763-1
Presenilin-I is indirectly implicated in Notchl cleavage, Lévesque, G., Carreau, M., Hébert, S.S., Ferland, M., Auclair, A., Godin, C., NeuroReport, 2003, 10.1097/00001756-200308260-00014
Fanconi's anemia: What have we learned from the genes so far?, Buchwald, M., Carreau, M., Molecular Medicine Today, 1998, 10.1016/S1357-4310(98)01243-X
HES1 is a novel interactor of the Fanconi anemia core complex, Carreau, M., Lévesque, G., Godin, C., Habi, O., Huard, C.C., Huang, F.F., Tremblay, C.S., Blood, 2008, 10.1182/blood-2008-04-152710
The Caenorhabditis elegans FancD2 ortholog is required for survival following DNA damage, Desnoyers, S., Carreau, M., Gagnon, S.N., St-Laurent, J.-F., Dequen, F., Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology, 2005, 10.1016/j.cbpc.2005.05.010
Short-term granulocyte colony-stimulating factor and erythropoietin treatment enhances hematopoiesis and survival in the mitomycin C-conditioned Fancc^-/- mouse model, while long-term treatment is ineffective, Buchwald, M., Dick, J.E., Hitzler, J.K., Gan, O.I., Liu, L., Carreau, M., Blood, 2002, 10.1182/blood-2001-11-0007
Correction of Fanconi Anemia Group C Hematopoietic Stem Cells Following Intrafemoral Gene Transfer, Madeleine Carreau, Marie-Chantal Delisle, Valérie Bourdages, Johanne Girard, Ouassila Habi, Anemia, 2010, 10.1155/2010/947816
The fanconi anemia group C protein interacts with uncoordinated 5A and delays apoptosis, Carreau, M., Lévesque, G., Godin, C., Huard, C.C., Magron, A., Aissa, M.B., Huang, F., PLoS ONE, 2014, 10.1371/journal.pone.0092811
Multiple inhibitory cytokines induce deregulated progenitor growth and apoptosis in hematopoietic cells from Fac(-/-) mice, Clapp, D.W., Buchwald, M., Carreau, M., Hangoc, G., Cooper, S., Broxmeyer, H.E., Haneline, L.S., Blood, 1998
Fanconi anemia proteins interact with CtBP1 and modulate the expression of the Wnt antagonist Dickkopf-1, Carreau, M., Ĺevesque, G., Schindler, D., Delisle, M.-C., Helsper, K., Tremblay, C.S., Huard, C.C., Blood, 2013, 10.1182/blood-2012-02-408997
Presenilin-1 interacts directly with the β-site amyloid protein precursor cleaving enzyme (BACE1), Lévesque, G., Carreau, M., Ferland, M., Godin, C., Bourdages, V., Hébert, S.S., Neurobiology of Disease, 2003, 10.1016/S0969-9961(03)00035-4
Hematopoietic stem cells from Fancc^-/- mice have lower growth and differentiation potential in response to growth factors, Carreau, M., Goulet, I., Charbonneau, C., Lafrance, M., Aub́, M., Stem Cells, 2002, 10.1634/stemcells.20-5-438
Fanconi anemia core complex-dependent HES1 mono-ubiquitination regulates its transcriptional activity, Carreau, M., Lévesque, G., Huang, F.F., Tremblay, C.S., BMC Research Notes, 2018, 10.1186/s13104-018-3243-7
Elevated blood levels of Dickkopf-1 are associated with acute infections, Carreau, M., Schindler, D., St-Louis, M., Larouche, V., Mazon, M., Immunity Inflammation and Disease, 2018, 10.1002/iid3.232
Not-so-novel phenotypes in the Fanconi anemia group D2 mouse model [3], Carreau, M., Blood, 2004, 10.1182/blood-2003-11-3946
Hematopoietic compartment of Fanconi anemia group C null mice contains fewer lineage-negative CD34⁺ primitive hematopoietic cells and shows reduced reconstitution ability, Buchwald, M., Dick, J.E., Doedens, M., Liu, L., Gan, O.I., Carreau, M., Experimental Hematology, 1999, 10.1016/S0301-472X(99)00102-2
Fanconi anemia genes are highly expressed in primitive CD34⁺ hematopoietic cells, Carreau, M., Delisle, M.-C., Brodeur, I., Lafrance, M., Aubé, M., BMC Blood Disorders, 2003, 10.1186/1471-2326-3-1
Development and characterization of immortalized fibroblastoid cell lines from an FA(C) mouse model, Buchwald, M., Carreau, M., Care, M., Tomkins, D.J., Mutation Research - DNA Repair, 1998, 10.1016/S0921-8777(98)00015-9
Fanconi Anemia Proteins and Their Interacting Partners: A Molecular Puzzle, Madeleine Carreau, Tagrid Kaddar, Anemia, 2012, 10.1155/2012/425814
The Fanconi anaemia group G gene FANCG is identical with XRCC9, Joenje, H., Buchwald, M., Digweed, M., Hoehn, H., Arwert, F., Pronk, J.C., Schindler, D., Demuth, I., Bender, O., Carreau, M., Alon, N., Bosnoyan-Collins, L., Van Berkel, C.G.M., Rooimans, M.A., Waisfisz, Q., De Winter, J.P., Nature Genetics, 1998, 10.1038/3093
Deletion of the Fanconi Anemia C Gene in Mice Leads to Skeletal Anomalies and Defective Bone Mineralization and Microarchitecture, Carreau, M., Mac-Way, F., Frenette, J., Filiatrault, J., Tam, R., Hamoudi, D., Picard, S., Ung, R.-V., Julien, J., Mazon, M., Journal of Bone and Mineral Research, 2018, 10.1002/jbmr.3546
Naturally occurring FANCF-Hes1 complex inhibitors from Wrightia religiosa, Ishibashi, M., Carreau, M., Kaddar, T., Kowithayakorn, T., Ishikawa, N., Koyano, T., Hamahiga, N., Uemura, K., Arai, M.A., MedChemComm, 2015, 10.1039/c4md00495g

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Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2020/06

Camila Oliveira Antes - Post-doctorat - En cours

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Direction de recherche dans les domaines suivants :

Biologie cellulaire et moléculaire
Médecine moléculaire
Sciences cliniques et biomédicales

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.

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