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Madeleine Carreau

Professeure titulaire

Madeleine.Carreau@fmed.ulaval.ca
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Oncologie
Médecine régénératrice et moléculaire
Reproduction, génétique, périnatalité et développement

Domaines et intérêts de recherche du (de la) professeur(e) :

Santé de la mère, des enfants et des adolescents
  • Anomalies congénitales
Cancer
Cellulaire
Organisation et fonctions biologiques
Organismes vivants (êtres humains - Psychologie/aspects biologiques)

Projets de recherche

  • Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
  • To understand the molecular basis of carcinogenesis in FA. - Fanconi Anemia Research Fund, Inc., chercheur principal - 2020-12-01 au 2023-11-30

Publications

  • FANCC localizes with UNC5A at neurite outgrowth and promotes neuritogenesis, Huang, F., Ben Aissa, M., Lévesque, G., Carreau, M., BMC Research Notes, 2018, 10.1186/s13104-018-3763-1
  • Modulating Dickkopf-1: A strategy to monitor or treat cancer?, Mazon, M., Masi, D., Carreau, M., Cancers, 2016, 10.3390/cancers8070062
  • Naturally occurring FANCF-Hes1 complex inhibitors from Wrightia religiosa, Arai, M.A., Uemura, K., Hamahiga, N., Ishikawa, N., Koyano, T., Kowithayakorn, T., Kaddar, T., Carreau, M., Ishibashi, M., MedChemComm, 2015, 10.1039/c4md00495g
  • The Fanconi anemia C protein binds to and regulates stathmin-1 phosphorylation, Magron, A., Elowe, S., Carreau, M., PLoS ONE, 2015, 10.1371/journal.pone.0140612
  • The fanconi anemia group C protein interacts with uncoordinated 5A and delays apoptosis, Huang, F., Aissa, M.B., Magron, A., Huard, C.C., Godin, C., Lévesque, G., Carreau, M., PLoS ONE, 2014, 10.1371/journal.pone.0092811
  • Fanconi anemia genes are highly expressed in primitive CD34+ hematopoietic cells, Aubé, M., Lafrance, M., Brodeur, I., Delisle, M.-C., Carreau, M., BMC Blood Disorders, 2003, 10.1186/1471-2326-3-1
  • Hematopoietic compartment of Fanconi anemia group C null mice contains fewer lineage-negative CD34+ primitive hematopoietic cells and shows reduced reconstitution ability, Carreau, M., Gan, O.I., Liu, L., Doedens, M., Dick, J.E., Buchwald, M., Experimental Hematology, 1999, 10.1016/S0301-472X(99)00102-2
  • Loss of FancC function results in decreased hematopoietic stem cell repopulating ability, Haneline, L.S., Gobbett, T.A., Ramani, R., Carreau, M., Buchwald, M., Yoder, M.C., Clapp, D.W., Blood, 1999, 10.1182/blood.v94.1.1.413k03_1_8
  • Mitomycin C-induced DNA damage in Fanconi anemia: Cross-linking or redox-mediated effects? [7] (multiple letters), Pagano, G., Zatterale, A., Korkina, L.G., Carreau, M., Buchwald, M., Blood, 1999, 10.1182/blood.v93.3.1116
  • Development and characterization of immortalized fibroblastoid cell lines from an FA(C) mouse model, Tomkins, D.J., Care, M., Carreau, M., Buchwald, M., Mutation Research - DNA Repair, 1998, 10.1016/S0921-8777(98)00015-9
  • Multiple inhibitory cytokines induce deregulated progenitor growth and apoptosis in hematopoietic cells from Fac(-/-) mice, Haneline, L.S., Broxmeyer, H.E., Cooper, S., Hangoc, G., Carreau, M., Buchwald, M., Clapp, D.W., Blood, 1998
  • Functional Retroviral Vector for Gene Therapy of Xeroderma Pigmentosum Group D Patients, Carreau, M., Quilliet, X., Eveno, E., Salvetti, A., Danos, O., Heard, J.-M., Mezzina, M., Sarasin, A., Human Gene Therapy, 1995, 10.1089/hum.1995.6.10-1307
  • Correction by the ercc2 gene of UV sensitivity and repair deficiency phenotype in a subset of trichothiodystrophy cells, Mezzina, M., Eveno, E., Chevallier-lagente, O., Benoit, A., Carreau, M., Vermeulen, W., Hoeijmakers, J.H.J., Stefanini, M., Lehmann, A.R., A. Weber, C., Sarasin, A., Carcinogenesis, 1994, 10.1093/carcin/15.8.1493
  • Elevated blood levels of Dickkopf-1 are associated with acute infections, Mazon, M., Larouche, V., St-Louis, M., Schindler, D., Carreau, M., Immunity Inflammation and Disease, 2018, 10.1002/iid3.232
  • The Fanconi anemia pathway has a dual function in Dickkopf-1 transcriptional repression, Huard, C.C., Tremblay, C.S., Magron, A., Lévesque, G., Carreau, M., Proceedings of the National Academy of Sciences of the United States of America, 2014, 10.1073/pnas.1314226111
  • Fanconi anemia proteins interact with CtBP1 and modulate the expression of the Wnt antagonist Dickkopf-1, Huard, C.C., Tremblay, C.S., Helsper, K., Delisle, M.-C., Schindler, D., Ĺevesque, G., Carreau, M., Blood, 2013, 10.1182/blood-2012-02-408997
  • Fanconi Anemia Proteins and Their Interacting Partners: A Molecular Puzzle, Tagrid Kaddar, Madeleine Carreau, Anemia, 2012, 10.1155/2012/425814
  • Correction of Fanconi Anemia Group C Hematopoietic Stem Cells Following Intrafemoral Gene Transfer, Ouassila Habi, Johanne Girard, Valérie Bourdages, Marie-Chantal Delisle, Madeleine Carreau, Anemia, 2010, 10.1155/2010/947816
  • HES1 is a novel interactor of the Fanconi anemia core complex, Tremblay, C.S., Huang, F.F., Habi, O., Huard, C.C., Godin, C., Lévesque, G., Carreau, M., Blood, 2008, 10.1182/blood-2008-04-152710
  • Regulation of the Fanconi Anemia Group C Protein through Proteolytic Modification, Brodeur, I., Goulet, I., Tremblay, C.S., Charbonneau, C., Delisle, M.-C., Godin, C., Huard, C., Khandjian, E.W., Buchwald, M., Lévesque, G., Carreau, M., Journal of Biological Chemistry, 2004, 10.1074/jbc.M301291200
  • Bone marrow failure in the fanconi anemia group C mouse model after DNA damage, Carreau, M., Gan, O.I., Liu, L., Doedens, M., McKerlie, C., Dick, J.E., Buchwald, M., Blood, 1998, 10.1182/blood.v91.8.2737.2737_2737_2744
  • Fanconi's anemia: What have we learned from the genes so far?, Carreau, M., Buchwald, M., Molecular Medicine Today, 1998, 10.1016/S1357-4310(98)01243-X
  • Expression cloning of a cdna for the major fanconi anaemia gene, FAA, Ten Foe, J.R.L., Rooimans, M.A., Bosnoyan-Collins, L., Alon, N., Wijker, M., Parker, L., Lightfoot, J., Carreau, M., Callen, D.F., Savoia, A., Cheng, N.C., Van Berkel, C.C.M., Strunk, M.H.P., Gille, J.J.P., Pals, G., Kruyt, F.A.E., Pronk, J.C., Arwert, F., Buchwald, M., Joenje, H., Nature Genetics, 1996, 10.1038/ng1196-320
  • Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia, Chen, M., Tomkins, D.J., Auerbach, W., McKerlie, C., Youssoufian, H., Liu, L., Gan, O., Carreau, M., Auerbach, A., Groves, T., Guidos, C.J., Freedman, M.H., Cross, J., Percy, D.H., Dick, J.E., Joyner, A.L., Buchwald, M., Nature Genetics, 1996, 10.1038/ng0496-448
  • Development of a new easy complementation assay for DNA repair deficient human syndromes using cloned repair genes, Carreau, M., Eveno, E., Quilliet, X., Chevalier-lagente, O., Benoit, A., Tanganelli, B., Stefanini, M., Vermeulen, W., Hoeijmakers, J.H.J., Sarasin, A., Mezzina, M., Carcinogenesis, 1995, 10.1093/carcin/16.5.1003
  • Elevated blood levels of Dickkopf-1 are associated with acute infections, Mazon, M., Larouche, V., St-Louis, M., Schindler, D., Carreau, M., Immunity Inflammation and Disease, 2018, 10.1002/iid3.232
  • The Fanconi anemia pathway has a dual function in Dickkopf-1 transcriptional repression, Huard, C.C., Tremblay, C.S., Magron, A., Lévesque, G., Carreau, M., Proceedings of the National Academy of Sciences of the United States of America, 2014, 10.1073/pnas.1314226111
  • Fanconi anemia proteins interact with CtBP1 and modulate the expression of the Wnt antagonist Dickkopf-1, Huard, C.C., Tremblay, C.S., Helsper, K., Delisle, M.-C., Schindler, D., Ĺevesque, G., Carreau, M., Blood, 2013, 10.1182/blood-2012-02-408997
  • Fanconi Anemia Proteins and Their Interacting Partners: A Molecular Puzzle, Tagrid Kaddar, Madeleine Carreau, Anemia, 2012, 10.1155/2012/425814
  • Correction of Fanconi Anemia Group C Hematopoietic Stem Cells Following Intrafemoral Gene Transfer, Ouassila Habi, Johanne Girard, Valérie Bourdages, Marie-Chantal Delisle, Madeleine Carreau, Anemia, 2010, 10.1155/2010/947816
  • HES1 is a novel interactor of the Fanconi anemia core complex, Tremblay, C.S., Huang, F.F., Habi, O., Huard, C.C., Godin, C., Lévesque, G., Carreau, M., Blood, 2008, 10.1182/blood-2008-04-152710
  • Regulation of the Fanconi Anemia Group C Protein through Proteolytic Modification, Brodeur, I., Goulet, I., Tremblay, C.S., Charbonneau, C., Delisle, M.-C., Godin, C., Huard, C., Khandjian, E.W., Buchwald, M., Lévesque, G., Carreau, M., Journal of Biological Chemistry, 2004, 10.1074/jbc.M301291200
  • Bone marrow failure in the fanconi anemia group C mouse model after DNA damage, Carreau, M., Gan, O.I., Liu, L., Doedens, M., McKerlie, C., Dick, J.E., Buchwald, M., Blood, 1998, 10.1182/blood.v91.8.2737.2737_2737_2744
  • Fanconi's anemia: What have we learned from the genes so far?, Carreau, M., Buchwald, M., Molecular Medicine Today, 1998, 10.1016/S1357-4310(98)01243-X
  • Expression cloning of a cdna for the major fanconi anaemia gene, FAA, Ten Foe, J.R.L., Rooimans, M.A., Bosnoyan-Collins, L., Alon, N., Wijker, M., Parker, L., Lightfoot, J., Carreau, M., Callen, D.F., Savoia, A., Cheng, N.C., Van Berkel, C.C.M., Strunk, M.H.P., Gille, J.J.P., Pals, G., Kruyt, F.A.E., Pronk, J.C., Arwert, F., Buchwald, M., Joenje, H., Nature Genetics, 1996, 10.1038/ng1196-320
  • Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia, Chen, M., Tomkins, D.J., Auerbach, W., McKerlie, C., Youssoufian, H., Liu, L., Gan, O., Carreau, M., Auerbach, A., Groves, T., Guidos, C.J., Freedman, M.H., Cross, J., Percy, D.H., Dick, J.E., Joyner, A.L., Buchwald, M., Nature Genetics, 1996, 10.1038/ng0496-448
  • Development of a new easy complementation assay for DNA repair deficient human syndromes using cloned repair genes, Carreau, M., Eveno, E., Quilliet, X., Chevalier-lagente, O., Benoit, A., Tanganelli, B., Stefanini, M., Vermeulen, W., Hoeijmakers, J.H.J., Sarasin, A., Mezzina, M., Carcinogenesis, 1995, 10.1093/carcin/16.5.1003
  • Deletion of the Fanconi Anemia C Gene in Mice Leads to Skeletal Anomalies and Defective Bone Mineralization and Microarchitecture, Mazon, M., Julien, J., Ung, R.-V., Picard, S., Hamoudi, D., Tam, R., Filiatrault, J., Frenette, J., Mac-Way, F., Carreau, M., Journal of Bone and Mineral Research, 2018, 10.1002/jbmr.3546
  • Fanconi anemia core complex-dependent HES1 mono-ubiquitination regulates its transcriptional activity, Tremblay, C.S., Huang, F.F., Lévesque, G., Carreau, M., BMC Research Notes, 2018, 10.1186/s13104-018-3243-7
  • The fanconi anemia core complex acts as a transcriptional co-regulator in hairy enhancer of split 1 signaling, Tremblay, C.S., Huard, C.C., Huang, F.-F., Habi, O., Bourdages, V., Lévesque, G., Carreau, M., Journal of Biological Chemistry, 2009, 10.1074/jbc.M807921200
  • Lack of self-renewal capacity in Fancc-/- stem cells after ex vivo expansion, Habi, O., Delisle, M.-C., Messier, N., Carreau, M., Stem Cells, 2005, 10.1634/stemcells.2004-0356
  • The Caenorhabditis elegans FancD2 ortholog is required for survival following DNA damage, Dequen, F., St-Laurent, J.-F., Gagnon, S.N., Carreau, M., Desnoyers, S., Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology, 2005, 10.1016/j.cbpc.2005.05.010
  • Not-so-novel phenotypes in the Fanconi anemia group D2 mouse model [3], Carreau, M., Blood, 2004, 10.1182/blood-2003-11-3946
  • Presenilin-1 interacts directly with the β-site amyloid protein precursor cleaving enzyme (BACE1), Hébert, S.S., Bourdages, V., Godin, C., Ferland, M., Carreau, M., Lévesque, G., Neurobiology of Disease, 2003, 10.1016/S0969-9961(03)00035-4
  • Presenilin-I is indirectly implicated in Notchl cleavage, Godin, C., Auclair, A., Ferland, M., Hébert, S.S., Carreau, M., Lévesque, G., NeuroReport, 2003, 10.1097/00001756-200308260-00014
  • Hematopoietic stem cells from Fancc-/- mice have lower growth and differentiation potential in response to growth factors, Aub́, M., Lafrance, M., Charbonneau, C., Goulet, I., Carreau, M., Stem Cells, 2002, 10.1634/stemcells.20-5-438
  • Short-term granulocyte colony-stimulating factor and erythropoietin treatment enhances hematopoiesis and survival in the mitomycin C-conditioned Fancc-/- mouse model, while long-term treatment is ineffective, Carreau, M., Liu, L., Gan, O.I., Hitzler, J.K., Dick, J.E., Buchwald, M., Blood, 2002, 10.1182/blood-2001-11-0007
  • Drug sensitivity spectra in Fanconi anemia lymphoblastoid cell lines of defined complementation groups, Carreau, M., Alon, N., Bosnoyan-Collins, L., Joenje, H., Buchwald, M., Mutation Research - DNA Repair, 1999, 10.1016/S0921-8777(99)00041-5
  • The Fanconi anaemia group G gene FANCG is identical with XRCC9, De Winter, J.P., Waisfisz, Q., Rooimans, M.A., Van Berkel, C.G.M., Bosnoyan-Collins, L., Alon, N., Carreau, M., Bender, O., Demuth, I., Schindler, D., Pronk, J.C., Arwert, F., Hoehn, H., Digweed, M., Buchwald, M., Joenje, H., Nature Genetics, 1998, 10.1038/3093
  • The Fanconi anemia genes, Carreau, M., Buchwald, M., Current Opinion in Pediatrics, 1998, 10.1097/00008480-199802000-00013
  • Erratum: Expression cloning of a cDNA for the major Fanconi anaemia gene, FAA (Nature Genetics (1996) 14 (320-323)), Foe, J.R.L.T., Rooimans, M.A., Bosnoyan-Collins, L., Alon, N., Wijker, M., Parker, L., Lightfoot, J., Carreau, M., Callen, D.F., Savoia, A., Cheng, N.C., Van Berkel, C.G.M., Strunk, M.H.P., Gille, J.J.P., Pals, G., Kruyt, F.A.E., Pronk, J.C., Arwert, F., Buchwald, M., Joenje, H., Nature Genetics, 1996, 10.1038/ng1296-488b
  • Deletion of the Fanconi Anemia C Gene in Mice Leads to Skeletal Anomalies and Defective Bone Mineralization and Microarchitecture, Mazon, M., Julien, J., Ung, R.-V., Picard, S., Hamoudi, D., Tam, R., Filiatrault, J., Frenette, J., Mac-Way, F., Carreau, M., Journal of Bone and Mineral Research, 2018, 10.1002/jbmr.3546
  • Fanconi anemia core complex-dependent HES1 mono-ubiquitination regulates its transcriptional activity, Tremblay, C.S., Huang, F.F., Lévesque, G., Carreau, M., BMC Research Notes, 2018, 10.1186/s13104-018-3243-7
  • The fanconi anemia core complex acts as a transcriptional co-regulator in hairy enhancer of split 1 signaling, Tremblay, C.S., Huard, C.C., Huang, F.-F., Habi, O., Bourdages, V., Lévesque, G., Carreau, M., Journal of Biological Chemistry, 2009, 10.1074/jbc.M807921200
  • Lack of self-renewal capacity in Fancc-/- stem cells after ex vivo expansion, Habi, O., Delisle, M.-C., Messier, N., Carreau, M., Stem Cells, 2005, 10.1634/stemcells.2004-0356
  • The Caenorhabditis elegans FancD2 ortholog is required for survival following DNA damage, Dequen, F., St-Laurent, J.-F., Gagnon, S.N., Carreau, M., Desnoyers, S., Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology, 2005, 10.1016/j.cbpc.2005.05.010
  • Not-so-novel phenotypes in the Fanconi anemia group D2 mouse model [3], Carreau, M., Blood, 2004, 10.1182/blood-2003-11-3946
  • Presenilin-1 interacts directly with the β-site amyloid protein precursor cleaving enzyme (BACE1), Hébert, S.S., Bourdages, V., Godin, C., Ferland, M., Carreau, M., Lévesque, G., Neurobiology of Disease, 2003, 10.1016/S0969-9961(03)00035-4
  • Presenilin-I is indirectly implicated in Notchl cleavage, Godin, C., Auclair, A., Ferland, M., Hébert, S.S., Carreau, M., Lévesque, G., NeuroReport, 2003, 10.1097/00001756-200308260-00014
  • Hematopoietic stem cells from Fancc-/- mice have lower growth and differentiation potential in response to growth factors, Aub́, M., Lafrance, M., Charbonneau, C., Goulet, I., Carreau, M., Stem Cells, 2002, 10.1634/stemcells.20-5-438
  • Short-term granulocyte colony-stimulating factor and erythropoietin treatment enhances hematopoiesis and survival in the mitomycin C-conditioned Fancc-/- mouse model, while long-term treatment is ineffective, Carreau, M., Liu, L., Gan, O.I., Hitzler, J.K., Dick, J.E., Buchwald, M., Blood, 2002, 10.1182/blood-2001-11-0007
  • Drug sensitivity spectra in Fanconi anemia lymphoblastoid cell lines of defined complementation groups, Carreau, M., Alon, N., Bosnoyan-Collins, L., Joenje, H., Buchwald, M., Mutation Research - DNA Repair, 1999, 10.1016/S0921-8777(99)00041-5
  • The Fanconi anaemia group G gene FANCG is identical with XRCC9, De Winter, J.P., Waisfisz, Q., Rooimans, M.A., Van Berkel, C.G.M., Bosnoyan-Collins, L., Alon, N., Carreau, M., Bender, O., Demuth, I., Schindler, D., Pronk, J.C., Arwert, F., Hoehn, H., Digweed, M., Buchwald, M., Joenje, H., Nature Genetics, 1998, 10.1038/3093
  • The Fanconi anemia genes, Carreau, M., Buchwald, M., Current Opinion in Pediatrics, 1998, 10.1097/00008480-199802000-00013
  • Erratum: Expression cloning of a cDNA for the major Fanconi anaemia gene, FAA (Nature Genetics (1996) 14 (320-323)), Foe, J.R.L.T., Rooimans, M.A., Bosnoyan-Collins, L., Alon, N., Wijker, M., Parker, L., Lightfoot, J., Carreau, M., Callen, D.F., Savoia, A., Cheng, N.C., Van Berkel, C.G.M., Strunk, M.H.P., Gille, J.J.P., Pals, G., Kruyt, F.A.E., Pronk, J.C., Arwert, F., Buchwald, M., Joenje, H., Nature Genetics, 1996, 10.1038/ng1296-488b

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Théo Boyer - Doctorat - En cours
  • Camila Oliveira Antes - Post-doctorat - En cours
  • Erwan Le Nevé - Doctorat - En cours
  • Audrey Magron - Doctorat - 2015/01
  • Delphine Masi - Doctorat - 2017/09
  • Mélody Mazon - Doctorat - 2018/01

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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