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Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval- Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
To understand the molecular basis of carcinogenesis in FA.- Fanconi Anemia Research Fund, Inc., chercheur principal - 2020-12-01 au 2023-11-30
Understanding Head and Neck Squamous Cell Carcinoma onset in young adults- Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2018-10-01 au 2023-03-31
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Publications
Deletion of the Fanconi Anemia C Gene in Mice Leads to Skeletal Anomalies and Defective Bone Mineralization and Microarchitecture, Mazon, M., Julien, J., Ung, R.-V., Picard, S., Hamoudi, D., Tam, R., Filiatrault, J., Frenette, J., Mac-Way, F., Carreau, M., Journal of Bone and Mineral Research, 2018, 10.1002/jbmr.3546
Elevated blood levels of Dickkopf-1 are associated with acute infections, Mazon, M., Larouche, V., St-Louis, M., Schindler, D., Carreau, M., Immunity Inflammation and Disease, 2018, 10.1002/iid3.232
FANCC localizes with UNC5A at neurite outgrowth and promotes neuritogenesis, Huang, F., Ben Aissa, M., Lévesque, G., Carreau, M., BMC Research Notes, 2018, 10.1186/s13104-018-3763-1
Fanconi anemia core complex-dependent HES1 mono-ubiquitination regulates its transcriptional activity, Tremblay, C.S., Huang, F.F., Lévesque, G., Carreau, M., BMC Research Notes, 2018, 10.1186/s13104-018-3243-7
Modulating Dickkopf-1: A strategy to monitor or treat cancer?, Mazon, M., Masi, D., Carreau, M., Cancers, 2016, 10.3390/cancers8070062
Naturally occurring FANCF-Hes1 complex inhibitors from Wrightia religiosa, Arai, M.A., Uemura, K., Hamahiga, N., Ishikawa, N., Koyano, T., Kowithayakorn, T., Kaddar, T., Carreau, M., Ishibashi, M., MedChemComm, 2015, 10.1039/c4md00495g
The Fanconi anemia C protein binds to and regulates stathmin-1 phosphorylation, Magron, A., Elowe, S., Carreau, M., PLoS ONE, 2015, 10.1371/journal.pone.0140612
The fanconi anemia group C protein interacts with uncoordinated 5A and delays apoptosis, Huang, F., Aissa, M.B., Magron, A., Huard, C.C., Godin, C., Lévesque, G., Carreau, M., PLoS ONE, 2014, 10.1371/journal.pone.0092811
The Fanconi anemia pathway has a dual function in Dickkopf-1 transcriptional repression, Huard, C.C., Tremblay, C.S., Magron, A., Lévesque, G., Carreau, M., Proceedings of the National Academy of Sciences of the United States of America, 2014, 10.1073/pnas.1314226111
Fanconi anemia proteins interact with CtBP1 and modulate the expression of the Wnt antagonist Dickkopf-1, Huard, C.C., Tremblay, C.S., Helsper, K., Delisle, M.-C., Schindler, D., Ĺevesque, G., Carreau, M., Blood, 2013, 10.1182/blood-2012-02-408997
Fanconi Anemia Proteins and Their Interacting Partners: A Molecular Puzzle, Tagrid Kaddar, Madeleine Carreau, Anemia, 2012, 10.1155/2012/425814
Correction of Fanconi Anemia Group C Hematopoietic Stem Cells Following Intrafemoral Gene Transfer, Ouassila Habi, Johanne Girard, Valérie Bourdages, Marie-Chantal Delisle, Madeleine Carreau, Anemia, 2010, 10.1155/2010/947816
The fanconi anemia core complex acts as a transcriptional co-regulator in hairy enhancer of split 1 signaling, Tremblay, C.S., Huard, C.C., Huang, F.-F., Habi, O., Bourdages, V., Lévesque, G., Carreau, M., Journal of Biological Chemistry, 2009, 10.1074/jbc.M807921200
HES1 is a novel interactor of the Fanconi anemia core complex, Tremblay, C.S., Huang, F.F., Habi, O., Huard, C.C., Godin, C., Lévesque, G., Carreau, M., Blood, 2008, 10.1182/blood-2008-04-152710
Lack of self-renewal capacity in Fancc-/- stem cells after ex vivo expansion, Habi, O., Delisle, M.-C., Messier, N., Carreau, M., Stem Cells, 2005, 10.1634/stemcells.2004-0356
The Caenorhabditis elegans FancD2 ortholog is required for survival following DNA damage, Dequen, F., St-Laurent, J.-F., Gagnon, S.N., Carreau, M., Desnoyers, S., Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology, 2005, 10.1016/j.cbpc.2005.05.010
Not-so-novel phenotypes in the Fanconi anemia group D2 mouse model [3], Carreau, M., Blood, 2004, 10.1182/blood-2003-11-3946
Regulation of the Fanconi Anemia Group C Protein through Proteolytic Modification, Brodeur, I., Goulet, I., Tremblay, C.S., Charbonneau, C., Delisle, M.-C., Godin, C., Huard, C., Khandjian, E.W., Buchwald, M., Lévesque, G., Carreau, M., Journal of Biological Chemistry, 2004, 10.1074/jbc.M301291200
Fanconi anemia genes are highly expressed in primitive CD34+ hematopoietic cells, Aubé, M., Lafrance, M., Brodeur, I., Delisle, M.-C., Carreau, M., BMC Blood Disorders, 2003, 10.1186/1471-2326-3-1
Presenilin-1 interacts directly with the β-site amyloid protein precursor cleaving enzyme (BACE1), Hébert, S.S., Bourdages, V., Godin, C., Ferland, M., Carreau, M., Lévesque, G., Neurobiology of Disease, 2003, 10.1016/S0969-9961(03)00035-4
Presenilin-I is indirectly implicated in Notchl cleavage, Godin, C., Auclair, A., Ferland, M., Hébert, S.S., Carreau, M., Lévesque, G., NeuroReport, 2003, 10.1097/00001756-200308260-00014
Hematopoietic stem cells from Fancc-/- mice have lower growth and differentiation potential in response to growth factors, Aub́, M., Lafrance, M., Charbonneau, C., Goulet, I., Carreau, M., Stem Cells, 2002, 10.1634/stemcells.20-5-438
Short-term granulocyte colony-stimulating factor and erythropoietin treatment enhances hematopoiesis and survival in the mitomycin C-conditioned Fancc-/- mouse model, while long-term treatment is ineffective, Carreau, M., Liu, L., Gan, O.I., Hitzler, J.K., Dick, J.E., Buchwald, M., Blood, 2002, 10.1182/blood-2001-11-0007
Drug sensitivity spectra in Fanconi anemia lymphoblastoid cell lines of defined complementation groups, Carreau, M., Alon, N., Bosnoyan-Collins, L., Joenje, H., Buchwald, M., Mutation Research - DNA Repair, 1999, 10.1016/S0921-8777(99)00041-5
Hematopoietic compartment of Fanconi anemia group C null mice contains fewer lineage-negative CD34+ primitive hematopoietic cells and shows reduced reconstitution ability, Carreau, M., Gan, O.I., Liu, L., Doedens, M., Dick, J.E., Buchwald, M., Experimental Hematology, 1999, 10.1016/S0301-472X(99)00102-2
Loss of FancC function results in decreased hematopoietic stem cell repopulating ability, Haneline, L.S., Gobbett, T.A., Ramani, R., Carreau, M., Buchwald, M., Yoder, M.C., Clapp, D.W., Blood, 1999, 10.1182/blood.v94.1.1.413k03_1_8
Mitomycin C-induced DNA damage in Fanconi anemia: Cross-linking or redox-mediated effects? [7] (multiple letters), Pagano, G., Zatterale, A., Korkina, L.G., Carreau, M., Buchwald, M., Blood, 1999, 10.1182/blood.v93.3.1116
Bone marrow failure in the fanconi anemia group C mouse model after DNA damage, Carreau, M., Gan, O.I., Liu, L., Doedens, M., McKerlie, C., Dick, J.E., Buchwald, M., Blood, 1998, 10.1182/blood.v91.8.2737.2737_2737_2744
Development and characterization of immortalized fibroblastoid cell lines from an FA(C) mouse model, Tomkins, D.J., Care, M., Carreau, M., Buchwald, M., Mutation Research - DNA Repair, 1998, 10.1016/S0921-8777(98)00015-9
Fanconi's anemia: What have we learned from the genes so far?, Carreau, M., Buchwald, M., Molecular Medicine Today, 1998, 10.1016/S1357-4310(98)01243-X
Multiple inhibitory cytokines induce deregulated progenitor growth and apoptosis in hematopoietic cells from Fac(-/-) mice, Haneline, L.S., Broxmeyer, H.E., Cooper, S., Hangoc, G., Carreau, M., Buchwald, M., Clapp, D.W., Blood, 1998
The Fanconi anaemia group G gene FANCG is identical with XRCC9, De Winter, J.P., Waisfisz, Q., Rooimans, M.A., Van Berkel, C.G.M., Bosnoyan-Collins, L., Alon, N., Carreau, M., Bender, O., Demuth, I., Schindler, D., Pronk, J.C., Arwert, F., Hoehn, H., Digweed, M., Buchwald, M., Joenje, H., Nature Genetics, 1998, 10.1038/3093
The Fanconi anemia genes, Carreau, M., Buchwald, M., Current Opinion in Pediatrics, 1998, 10.1097/00008480-199802000-00013
Erratum: Expression cloning of a cDNA for the major Fanconi anaemia gene, FAA (Nature Genetics (1996) 14 (320-323)), Foe, J.R.L.T., Rooimans, M.A., Bosnoyan-Collins, L., Alon, N., Wijker, M., Parker, L., Lightfoot, J., Carreau, M., Callen, D.F., Savoia, A., Cheng, N.C., Van Berkel, C.G.M., Strunk, M.H.P., Gille, J.J.P., Pals, G., Kruyt, F.A.E., Pronk, J.C., Arwert, F., Buchwald, M., Joenje, H., Nature Genetics, 1996, 10.1038/ng1296-488b
Expression cloning of a cdna for the major fanconi anaemia gene, FAA, Ten Foe, J.R.L., Rooimans, M.A., Bosnoyan-Collins, L., Alon, N., Wijker, M., Parker, L., Lightfoot, J., Carreau, M., Callen, D.F., Savoia, A., Cheng, N.C., Van Berkel, C.C.M., Strunk, M.H.P., Gille, J.J.P., Pals, G., Kruyt, F.A.E., Pronk, J.C., Arwert, F., Buchwald, M., Joenje, H., Nature Genetics, 1996, 10.1038/ng1196-320
Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia, Chen, M., Tomkins, D.J., Auerbach, W., McKerlie, C., Youssoufian, H., Liu, L., Gan, O., Carreau, M., Auerbach, A., Groves, T., Guidos, C.J., Freedman, M.H., Cross, J., Percy, D.H., Dick, J.E., Joyner, A.L., Buchwald, M., Nature Genetics, 1996, 10.1038/ng0496-448
Development of a new easy complementation assay for DNA repair deficient human syndromes using cloned repair genes, Carreau, M., Eveno, E., Quilliet, X., Chevalier-lagente, O., Benoit, A., Tanganelli, B., Stefanini, M., Vermeulen, W., Hoeijmakers, J.H.J., Sarasin, A., Mezzina, M., Carcinogenesis, 1995, 10.1093/carcin/16.5.1003
Functional Retroviral Vector for Gene Therapy of Xeroderma Pigmentosum Group D Patients, Carreau, M., Quilliet, X., Eveno, E., Salvetti, A., Danos, O., Heard, J.-M., Mezzina, M., Sarasin, A., Human Gene Therapy, 1995, 10.1089/hum.1995.6.10-1307
Correction by the ercc2 gene of UV sensitivity and repair deficiency phenotype in a subset of trichothiodystrophy cells, Mezzina, M., Eveno, E., Chevallier-lagente, O., Benoit, A., Carreau, M., Vermeulen, W., Hoeijmakers, J.H.J., Stefanini, M., Lehmann, A.R., A. Weber, C., Sarasin, A., Carcinogenesis, 1994, 10.1093/carcin/15.8.1493
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Contribution à l'enseignement aux cycles supérieurs
Étudiant(e)s dirigé(e)s*
Depuis 2009
Erwan Le Nevé - Doctorat - En cours
Camila Oliveira Antes - Post-doctorat - En cours
Théo Boyer - Doctorat - En cours
Audrey Magron - Doctorat - 2015/01
Delphine Masi - Doctorat - 2017/09
Mélody Mazon - Doctorat - 2018/01
Encadrement d'étudiant(e)s pour les programmes suivants :
*Les supervisions d’étudiant(e)s de 1er cycle en
stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées
ultérieurement.
Vice-décanat à la recherche et aux études supérieures Pavillon Ferdinand-Vandry Université Laval 1050, avenue de la Médecine, local 4645 Québec (Québec) G1V 0A6 Canada
Catherine Comtois Agente de gestion des études etudes.sup2@fmed.ulaval.ca Biostatistique Épidémiologie Évaluation économique des technologies de la santé Santé publique
Marianne Rivest et Claudia Gonzalez Agentes de gestion des études etudes.sup1@fmed.ulaval.ca Biologie cellulaire et moléculaire Génomique fonctionnelle Médecine moléculaire Microbiologie-immunologie Neurosciences
Isabelle Tremblay Agente de gestion des études etudes.sup3@fmed.ulaval.ca Pédagogie universitaire en sciences de la santé Sciences cliniques et biomédicales Sciences de la réadaptation Prévention et gestion de la santé et de la sécurité au travail